Genomes and Genes
intercellular signaling peptides and proteins
Summary: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Publications331 found, 100 shown here
- Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptorK Tatemoto
Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371 8512, Japan
Biochem Biophys Res Commun 251:471-6. 1998....
- The Wnt signaling pathway in development and diseaseCatriona Y Logan
Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
Annu Rev Cell Dev Biol 20:781-810. 2004..The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions...
- Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesisTimothy F Day
Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Dev Cell 8:739-50. 2005..Controlling Wnt/beta-catenin signaling is a common molecular mechanism underlying chondrocyte and osteoblast differentiation and specification of intramembranous and endochondral ossification...
- Secreted antagonists of the Wnt signalling pathwayYoshiaki Kawano
Department of Cancer Cell Biology, Division of Medicine, Imperial College, London W12 0NN, UK
J Cell Sci 116:2627-34. 2003..In addition, there are other protein interactions that contribute to Wnt antagonist function. Moreover, certain sFRPs and Dkks do not antagonise Wnt function, which suggests that these families have as-yet-undiscovered functions...
- Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17Matt Baker
Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
Nature 442:916-9. 2006..Our results identify mutations in PGRN as a cause of neurodegenerative disease and indicate the importance of PGRN function for neuronal survival...
- Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationDonald A Glass
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
Dev Cell 8:751-64. 2005....
- PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissueToshiya Matsubara
Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
Cell Metab 15:38-50. 2012..Thus, PGRN is a key adipokine that mediates HFD-induced insulin resistance and obesity through production of IL-6 in adipose tissue, and may be a promising therapeutic target for obesity...
- The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in miceWei Tang
Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA
Science 332:478-84. 2011..They also suggest new potential therapeutic interventions for various TNFα-mediated pathologies and conditions, including rheumatoid arthritis...
- High bone density due to a mutation in LDL-receptor-related protein 5Lynn M Boyden
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
N Engl J Med 346:1513-21. 2002..Loss-of-function mutations in the gene for low-density lipoprotein receptor-related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause osteoporosis-pseudoglioma...
- Biochemical and functional characterization of three activated macrophage populationsJustin P Edwards
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Leukoc Biol 80:1298-307. 2006..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions...
- A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administrationThorsten Buch
Laboratory for Molecular Immunology, Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
Nat Methods 2:419-26. 2005..Notably, we show that the developing DT-specific antibody response is weak and not neutralizing, and thus does not impede the efficacy of DT. Our results validate the use of iDTR mice as a tool for cell ablation in vivo...
- DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathwayAtsushi Niida
Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Oncogene 23:8520-6. 2004..Our finding suggests the existence of a novel feedback loop in Wnt signaling...
- Granulin is a soluble cofactor for toll-like receptor 9 signalingBoyoun Park
Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, South Korea
Immunity 34:505-13. 2011..Thus, we propose that granulin contributes to innate immunity as a critical soluble cofactor for TLR9 signaling...
- The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1Zhicheng Dong
Biology Department and Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
Proc Natl Acad Sci U S A 105:9970-5. 2008..We show that recombinant HYL1 and SE proteins accelerate the rate of DCL1-mediated cleavage of pre- and pri-miR167b substrates and promote accurate processing...
- Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signallingBingyu Mao
Molecular Embryology Division, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Nature 417:664-7. 2002..The results indicate that Kremen1 and Kremen2 are components of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates...
- Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolismKerry B Goralski
Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
J Biol Chem 282:28175-88. 2007..We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism...
- WNT signals are required for the initiation of hair follicle developmentThomas Andl
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Cell 2:643-53. 2002..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
- MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiationSara T Hashimi
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
Blood 114:404-14. 2009..Thus, our novel approach identified and validated some miRNA-protein networks involved in phenotypic and functional MDDC differentiation...
- Essential role of beta-catenin in postnatal bone acquisitionSheri L Holmen
Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
J Biol Chem 280:21162-8. 2005..These findings suggest that Wnt/beta-catenin signaling in osteoblasts coordinates postnatal bone acquisition by controlling the differentiation and activity of both osteoblasts and osteoclasts...
- The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesisRui Benedito
Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
Cell 137:1124-35. 2009....
- LDL-receptor-related protein 6 is a receptor for Dickkopf proteinsB Mao
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Nature 411:321-5. 2001..Thus, DKKs inhibit Wnt co-receptor function, exemplifying the modulation of LRP signalling by antagonists...
- Osteoblastic cells regulate the haematopoietic stem cell nicheL M Calvi
Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
Nature 425:841-6. 2003..Niche constituent cells or signalling pathways provide pharmacological targets with therapeutic potential for stem-cell-based therapies...
- Apelin, a newly identified adipokine up-regulated by insulin and obesityJeremie Boucher
Institut National de la Santé et de la Recherche Médicale Unité 586, Institut Fédératif de Recherche 31, Centre Hospitalier Universitaire Rangueil, BP 84225 F 31432 Toulouse Cedex 4, France
Endocrinology 146:1764-71. 2005..The present work identifies apelin as a novel adipocyte endocrine secretion and focuses on its potential link with obesity-associated variations of insulin sensitivity status...
- Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligandsUmut Sahin
Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA
J Cell Biol 164:769-79. 2004..Identification of EGFR ligand sheddases is a crucial step toward understanding the mechanism underlying ectodomain release, and has implications for designing novel inhibitors of EGFR-dependent tumors...
- SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitorMikhail Semenov
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 280:26770-5. 2005..Our findings suggest that SOST is an antagonist for Wnt signaling and that the loss of SOST function likely leads to the hyperactivation of Wnt signaling that underlies bone overgrowth seen in sclerosteosis patients...
- Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signalingXiaofeng Li
Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, 06030, USA
J Biol Chem 280:19883-7. 2005....
- Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thalianaSascha Laubinger
Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
Proc Natl Acad Sci U S A 105:8795-800. 2008..Taken together, our results uncover dual roles in splicing and miRNA processing that distinguish SE and the cap-binding complex from specialized miRNA processing factors such as DCL1 and HYL1...
- Structure, function, and mechanism of progranulin; the brain and beyondHuishi Toh
Endocrine Research Laboratory, Royal Victoria Hospital, McGill University Health Centre Research Institute, 687 Pine Ave West, Montreal, QC, H3A 1A1, Canada
J Mol Neurosci 45:538-48. 2011..Here we review the structure, biology, and mechanism of progranulin action. By understanding PGRN in a wider context, we may be better able to delineate its roles in the normal brain and in neurodegenerative disease...
- Effect of NKG2D ligand expression on host immune responsesMarine Champsaur
Department of Microbiology and Immunology, The Biomedical Sciences Graduate Program and The Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Immunol Rev 235:267-85. 2010..We also discuss the host response to both membrane-bound and secreted NKG2D ligands and summarize the models proposed to explain the consequences of this differential expression...
- The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancerJose Manuel Gonzalez-Sancho
Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier 4, E 28029 Madrid, Spain
Oncogene 24:1098-103. 2005..Our data indicate that the Wnt/beta-catenin pathway is downregulated by the induction of DKK-1 expression, a mechanism that is lost in colon cancer...
- Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6M V Semenov
Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Curr Biol 11:951-61. 2001..The significance of the Fz-LRP6 complex in signal transduction remains to be established...
- GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarityTakeshi Yoshimura
Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
Cell 120:137-49. 2005..Knockdown of CRMP-2 inhibited NT-3-induced axon outgrowth. These results suggest that NT-3 decreases phosphorylated CRMP-2 and increases nonphosphorylated active CRMP-2, thereby promoting axon outgrowth...
- Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in miceMoshe Elkabets
Department of Medicine, Hematology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 121:784-99. 2011..Our data suggest that GRN and the unique hematopoietic BMCs that produce it might serve as novel therapeutic targets...
- In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigensSteffen Jung
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
Immunity 17:211-20. 2002..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii...
- Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusionsVivianna M Van Deerlin
1 Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA 2 These authors contributed equally to this work
Nat Genet 42:234-9. 2010..TMEM106B variants also contribute to genetic risk for FTLD-TDP in individuals with mutations in GRN. Our data implicate variants in TMEM106B as a strong risk factor for FTLD-TDP, suggesting an underlying pathogenic mechanism...
- Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plantsYuda Fang
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Curr Biol 17:818-23. 2007..On the basis of these data, we propose that D-bodies are crucial for orchestrating pri-miRNA processing and/or storage/assembly of miRNA-processing complexes in the nuclei of plant cells...
- Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiformeMarkus Hutterer
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
Clin Cancer Res 14:130-8. 2008..However, the effect of Axl and its ligand growth arrest--specific gene 6 (Gas6) in human gliomas is still unknown...
- Chemerin is a novel adipokine associated with obesity and metabolic syndromeKiymet Bozaoglu
Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia
Endocrinology 148:4687-94. 2007..Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome...
- Canonical Wnt signals are essential for homeostasis of the intestinal epitheliumDaniel Pinto
Netherlands Institute for Developmental Biology, Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Genes Dev 17:1709-13. 2003..Thus, our data are the first to establish a direct requirement for Wnt ligands in driving proliferation in the intestinal epithelium, and also define an unexpected role for Wnts in controlling secretory cell differentiation...
- Synthetic chemerin-derived peptides suppress inflammation through ChemR23Jenna L Cash
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
J Exp Med 205:767-75. 2008..Collectively, these results show that chemerin-derived peptides may represent a novel therapeutic strategy for the treatment of inflammatory diseases through ChemR23...
- Hippo pathway-independent restriction of TAZ and YAP by angiomotinSiew Wee Chan
Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
J Biol Chem 286:7018-26. 2011..These results reveal a novel mechanism to restrict the activity of TAZ and YAP through physical interaction with Amot and AmotL1...
- Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegenerationBasar Cenik
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 287:32298-306. 2012..Revealing the cell surface receptors and the intracellular functions of granulins and progranulin is crucial for understanding their contributions to neurodegeneration...
- Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cellsF Xing
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA
Oncogene 30:4075-86. 2011....
- Function and biological roles of the Dickkopf family of Wnt modulatorsC Niehrs
Department of Molecular Embryology, German Cancer Research Center, Heidelberg, Germany
Oncogene 25:7469-81. 2006..In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease...
- Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesisWei Jie Zhou
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Cell Res 21:609-26. 2011..We conclude that engagement of Robo1 by Slit2 induces malignant transformation through Hakai-mediated E-cad ubiquitination and lysosomal degradation during colorectal epithelial cell carcinogenesis...
- Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cellsLei Liu
State Key Laboratory of Reproductive Biology, Institute of Zoology, ChineseAcademy of Sciences, Beijing 100101, China
J Biol Chem 285:19483-90. 2010..These findings also provide a step forward toward understanding the operating mechanisms during reprogramming to produce iPS cells and can potentially promote the application of iPS cells in regenerative medicine and cancer therapy...
- Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repairJing Zhu
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
Cell 111:867-78. 2002..Supplying PEPI corrects the wound-healing defect in SLPI null mice. Thus, SLPI/elastase act via PEPI/EPIs to operate a switch at the interface between innate immunity and wound healing...
- LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signalingHui Wen Lue
Department of Biology, Georgia State University, Atlanta, Georgia, United States of America
PLoS ONE 6:e27720. 2011..LIV-1 could be an attractive therapeutic target for the eradication of pre-existing human prostate cancer and bone and soft tissue metastases...
- Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemiaHiroyasu Kidoya
Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
Blood 115:3166-74. 2010..Apelin inhibited the down-modulation of vascular endothelial-cadherin by VEGF, resulting in suppression of hyperpermeability. Our results suggest apelin efficacy for therapeutic angiogenesis...
- Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryosQinghua Tao
Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Cell 120:857-71. 2005..Second, we show that activation requires the glycosyl transferase X.EXT1. Third, we find that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling...
- LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINsRik Schrijvers
Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium
PLoS Pathog 8:e1002558. 2012..These results further support the potential of LEDGINs as allosteric integrase inhibitors...
- Differential effects of EGFR ligands on endocytic sorting of the receptorKirstine Roepstorff
Department of Cellular and Molecular Medicine, The Panum Building, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Traffic 10:1115-27. 2009..The Cbl ubiquitin ligases, especially c-Cbl, are responsible for EGFR ubiquitination after stimulation with all ligands, and persistent EGFR phosphorylation and ubiquitination largely correlate with receptor degradation...
- Nodal promotes growth and invasion in human gliomasC C Lee
Department of Pathology, Shin Kong Memorial Hospital, Taipei, Taiwan
Oncogene 29:3110-23. 2010..Furthermore, our data support the notion that Nodal may regulate glioma progression through the induction of the leukemia inhibitory factor (LIF) and Cripto-1 through activated Smad...
- Wnt signalling in stem cells and cancerTannishtha Reya
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 434:843-50. 2005....
- Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient miceFangfang Yin
Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
J Exp Med 207:117-28. 2010..FTD associated with PGRN insufficiency may result from many years of reduced neutrotrophic support together with cumulative damage in association with dysregulated inflammation...
- Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2alphaKlaus F Wagner
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Respir Cell Mol Biol 31:276-82. 2004..These results indicate a role for HIMF in lung development, possibly under the control of HIF-2, and suggest that HIMF regulates apoptosis and may participate in lung alveolarization and maturation...
- A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limbSteven A Vokes
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genes Dev 22:2651-63. 2008..These studies provide the first comprehensive characterization of the transcriptional output of a Shh-patterning process in the mammalian embryo and a framework for elaborating regulatory networks in the developing limb...
- Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancerVeronica Rodilla
Institut d Investigació Biomèdica de Bellvitge Gran Via km 2 7, Hospitalet and Institut Municipal d Investigacions Mèdiques Hospital del Mar, Dr Aiguader 88, 08003 Barcelona, Spain
Proc Natl Acad Sci U S A 106:6315-20. 2009..The Notch-specific genetic signature is sufficient to block differentiation and promote vasculogenesis in tumors whereas proliferation depends on both pathways...
- Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancerO Aguilera
Instituto de Investigaciones Biomédicas Alberto Sols and Departamento de Bioquímica, Facultad de Medicina, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
Oncogene 25:4116-21. 2006....
- Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brainA Reaux
Institut National de la Sante et de la Recherche Medicale, Paris, France Laboratory of Neuromorphology, Faculty of Medicine Semmelweis University, Budapest, Hungary
J Neurochem 77:1085-96. 2001..Together, these results suggest that neuronal apelin plays an important role in the central control of body fluid homeostasis...
- Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeysK Hotta
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
Diabetes 50:1126-33. 2001..No clear association was found between the plasma levels of adiponectin and its mRNA levels in adipose tissue. These results suggest that reduction in circulating adiponectin may be related to the development of insulin resistance...
- Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivoHeather E Fleming
Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Cell Stem Cell 2:274-83. 2008..Wnt pathway activation in the niche is required to limit HSC proliferation and preserve the reconstituting function of endogenous hematopoietic stem cells...
- A new secreted protein that binds to Wnt proteins and inhibits their activitiesJ C Hsieh
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 398:431-6. 1999....
- Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementiaRosa Rademakers
Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
Hum Mol Genet 17:3631-42. 2008..Translational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders...
- The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinasesT N Stitt
Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York 10591
Cell 80:661-70. 1995....
- A novel serum protein similar to C1q, produced exclusively in adipocytesP E Scherer
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
J Biol Chem 270:26746-9. 1995..Our experiments also further corroborate the existence of an insulin-regulated secretory pathway in adipocytes...
- Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in miceJ Fruebis
Genset Corporation, Functional Genomics, 875 Prospect Street, No. 206, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 98:2005-10. 2001..Thus, gAcrp30 is a novel pharmacological compound that controls energy homeostasis and exerts its effect primarily at the peripheral level...
- Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1Y Xue
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
Hum Mol Genet 8:723-30. 1999..These results establish the phenotype of Cm /+ mice as a contiguous gene deletion syndrome and demonstrate that Jag1 is essential for remodeling of the embryonic vasculature...
- Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1L Li
Stowers Institute for Medical Research, Department of Molecular Biotechnology, University of Washington, Seattle 98195 USA
Nat Genet 16:243-51. 1997....
- Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survivalTero Pekka Alastalo
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 5162, USA
J Clin Invest 121:3735-46. 2011..Taken together, our findings suggest that apelin could be effective in treating PAH by rescuing BMPR2 and PAEC dysfunction...
- Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryoChristopher M Cox
Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Tucson, AZ 85724 5044, USA
Dev Biol 296:177-89. 2006..Taken together, these studies indicate that apelin is required for normal vascular development in the frog embryo and has properties consistent with a role during normal and pathological angiogenesis...
- Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lungWeiguo Shu
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Biol 283:226-39. 2005..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling...
- Insulin-sensitive obesityNora Kloting
Department of Medicine, Interdisciplinary Centre for Clinical Research, University of Leipzig, Germany
Am J Physiol Endocrinol Metab 299:E506-15. 2010..This suggests that mechanisms beyond a positive caloric balance such as inflammation and adipokine release determine the pathological metabolic consequences in patients with obesity...
- Identification and functional analysis of endothelial tip cell-enriched genesRaquel del Toro
Inserm U833, Paris, France
Blood 116:4025-33. 2010..Thus, tip cells may regulate angiogenesis via matrix remodeling, production of basement membrane, and release of secreted molecules, some of which regulate stalk cell behavior...
- Wnt signaling in the intestinal epithelium: from endoderm to cancerAlex Gregorieff
Netherlands Institute for Developmental Biology, Hubrecht Laboratory, 3584 CT Utrecht, The Netherlands
Genes Dev 19:877-90. 2005..In this review, we outline current understanding of the physiological role of Wnt signaling in intestinal biology. From this perspective, we then describe how mutational subversion of the Wnt cascade leads to colorectal cancer...
- Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitusFederico Soriguer
Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
Obes Surg 19:1574-80. 2009..We measured the changes in apelin levels in morbidly obese subjects, with and without diabetes, and in the inverse situation of improvement in carbohydrate metabolism as a result of bariatric surgery...
- Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9Yuhui Wang
Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
Cell Metab 9:287-302. 2009..Thus, Sox9 is a Pref-1 target, and Pref-1 directs multipotent mesenchymal cells to the chondrogenic lineage but inhibits differentiation into adipocytes as well as osteoblasts and chondrocytes...
- The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2Tien Shun Yeh
Department of Anatomy and Cell Biology, National Yang Ming University, Taipei 112, Taiwan
Cancer Res 69:5039-48. 2009..Taken together, these results suggest that activation of Notch1 signal pathway promotes progression of gastric cancer, at least in part through COX-2...
- Macrophage Wnt7b is critical for kidney repair and regenerationShuei Liong Lin
Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:4194-9. 2010....
- The many facets of Notch ligandsB D'Souza
Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1737, USA
Oncogene 27:5148-67. 2008..Oncogene (2008) 27, 5148-5167; doi:10.1038/onc.2008.229...
- Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherinKevin G Leong
Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
J Exp Med 204:2935-48. 2007..Our findings suggest that ligand-induced Notch activation, through the induction of Slug, promotes tumor growth and metastasis characterized by epithelial-to-mesenchymal transition and inhibition of anoikis...
- Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinomaXianzhou Song
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 117:734-43. 2011..Although previous studies have identified the role of Axl in the transformation, proliferation, survival, and invasion in cancers, the expression and functions of Axl in pancreatic cancer have not been studied in detail...
- Genomic imprinting at the mammalian Dlk1-Dio3 domainSimao Teixeira da Rocha
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
Trends Genet 24:306-16. 2008..Here, we discuss the function and regulation of imprinting at this domain...
- Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integrationAndrea L Ferris
HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 107:3135-40. 2010..The ability to redirect HIV-1 DNA integration may help solve the problems associated with the activation of oncogenes when retroviruses are used in gene therapy...
- Neomorphic agouti mutations in obese yellow miceD M Duhl
Department of Pediatrics, Stanford School of Medicine, California 94305
Nat Genet 8:59-65. 1994..These results provide a model for other genes that show allele-specific imprinting, and demonstrate that molecular mechanisms typically responsible for activation of proto-oncogenes can also lead to other disease phenotypes...
- Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathwayHiroshi Doi
Department of Medicine and Biological Science, Education and Research Center, Laboratory Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, Japan
J Biol Chem 281:28555-64. 2006..Given that Notch pathway components are expressed in vascular SMC during normal development and disease, Notch signaling is likely to play a pivotal role in such situations to modulate the vascular smooth muscle cell phenotype...
- The granulin gene family: from cancer to dementiaAndrew Bateman
Endocrine Research Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada
Bioessays 31:1245-54. 2009..In this review we will discuss current knowledge of the multifaceted biology of PGRN...
- LEDGF hybrids efficiently retarget lentiviral integration into heterochromatinRik Gijsbers
Division of Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
Mol Ther 18:552-60. 2010..Thus, engineered LEDGF/p75 chimeras provide technology for controlling integration site selection by lentiviral vectors...
- In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75Melissa McNeely
Laboratory for Molecular Virology and Gene Therapy, Molecular Medicine, KULeuven and IRC KULAK, Kapucijnenvoer 33, B 3000 Leuven, Flanders, Belgium
J Mol Biol 410:811-30. 2011....
- SERRATE is a novel nuclear regulator in primary microRNA processing in ArabidopsisLi Yang
National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
Plant J 47:841-50. 2006..Our data strongly suggest that SE plays an important and general role in pri-miRNA processing, and it would be interesting to determine whether animal SE homologues may play similar roles in vivo...
- AXL is an essential factor and therapeutic target for metastatic ovarian cancerErinn B Rankin
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Center for Clinical Sciences Research, Stanford University, Stanford, California 94305 5152, USA
Cancer Res 70:7570-9. 2010..Furthermore, this study defines the soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer, for which current therapies are ineffective...
- Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomesMahmood Mohtashami
Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
J Immunol 185:867-76. 2010....
- Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulinFenghua Hu
Department of Neurology, Yale University School of Medicine, New Haven, CT 06536, USA
Neuron 68:654-67. 2010..5- to 5-fold. The 50% PGRN decrease causative in FTLD-TDP cases is mimicked in GRN+/⁻ mice, and is fully normalized by Sort1 ablation. Sortilin-mediated PGRN endocytosis is likely to play a central role in FTLD-TDP pathophysiology...
- Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulinKai Kessenbrock
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
J Clin Invest 118:2438-47. 2008..We conclude that PR3 and NE enhance neutrophil-dependent inflammation by eliminating the local antiinflammatory activity of PGRN. Our results support the use of serine protease inhibitors as antiinflammatory agents...
- TGF-beta signaling and the fibrotic responseAndrew Leask
Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill St, London, UK NW3 2PF
FASEB J 18:816-27. 2004....
- Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivityClare L Bennett
Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
J Cell Biol 169:569-76. 2005..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...
- A neurodegenerative disease mutation that accelerates the clearance of apoptotic cellsAimee W Kao
Departments of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:4441-6. 2011..We propose that cells that might otherwise recover from damage or injury are destroyed in progranulin mutants, which in turn facilitates disease progression...
- Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a reviewHarro Seelaar
Department of Neurology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
J Neurol Neurosurg Psychiatry 82:476-86. 2011..The potential to establish an early diagnosis, predict underlying pathology during life and quantify disease progression will all be required for disease-specific therapeutic trials in the future...
- Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesisSacri R Ferron
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
Nature 475:381-5. 2011....
- Tyro-3 family receptors are essential regulators of mammalian spermatogenesisQ Lu
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 398:723-8. 1999..Additional observations indicate that these receptors may also be essential for the tropic maintenance of diverse cell types in the mature nervous, immune and reproductive systems...
- Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family membersNiCole Finch
Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Brain 132:583-91. 2009..We propose that plasma GRN levels could be used as a reliable and inexpensive tool to identify all GRN mutation carriers in early-onset dementia populations and asymptomatic at-risk individuals...
- Somatomedin: Autologous Regulator of Bone FormationErnesto Canalis; Fiscal Year: 2008..These investigations should clarify the role of CHOP in bone cell differentiation and function. [unreadable] [unreadable]..
- Metalloproteinase regulation of ErbB signaling in skinStefan Stoll; Fiscal Year: 2006..Specific Aim 2 determines whether and in which contexts ADAM10 is involved in the shedding of ErbB ligands in human KCs. ..
- NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEMKenneth Hensley; Fiscal Year: 2005..abstract_text> ..
- CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMINGHal Broxmeyer; Fiscal Year: 2005..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
- MOLECULAR RECLASSIFICATION OF PROSTATIC CANCERGeorge Michalopoulos; Fiscal Year: 2004..abstract_text> ..
- Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNANaoki Yoshimura; Fiscal Year: 2004..This research project is important to provide a solid basis for potential future clinical application. ..
- Surfactant Protein C Mutations:Interstitial Lung DiseaseMichael Beers; Fiscal Year: 2006..unreadable] [unreadable]..
- MECHANISMS OF ARSENIC CARCINOGENESISTOM HEI; Fiscal Year: 2005..abstract_text> ..
- Inhibition of VEGF Mediated Angiogenesis by TIMP-3Bela Anand Apte; Fiscal Year: 2009..2. To determine the potential role of heparin/heparan sulfate binding on the angiostatic activity of TIMP-3. 3. To determine the VEGF mediated angiogenic response and tumor growth in TIMP-3 null mice. ..
- Peroxiredoxin 6 and CataractogenesisDhirendra P Singh; Fiscal Year: 2010..The proposed studies will provide a sound scientific basis for developing an antioxidant-based therapy or combination of therapies for preventing cataractogenesis and age-associated degenerative diseases in general. ..
- Growth Factors and Colon CancerMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
- TGF BETA Regulation of Osteoclast ApoptosisMERRY OURSLER; Fiscal Year: 2007..Understanding osteoclast apoptosis regulation may provide important avenues for therapies to slow bone degradation during pathological bone loss. ..
- Cryptococcus traversal of Brain Endothelial cellsKwang Kim; Fiscal Year: 2007..neoformans traversal of HBMEC monolayers and will be the basis of future investigations to characterize microbial-host interactions that are relevant to the pathogenesis of cryptococcal meningitis/meningoencephalitis. ..
- Control of lymphatic endothelial differentiation programKari Alitalo; Fiscal Year: 2006..They should also identify molecular markers distinguishing superficial and visceral lymphatic vessels, which could then be used to develop targeted drug delivery to these vessels. ..
- Post-Synthetic Procollagen Processing in Load-Induced Left Ventricular RemodelingAMY DODD BRADSHAW; Fiscal Year: 2010..Thus, this project will examine whether alteration in SPARC-dependent procollagen processing is a fundamental mechanism by which PO increases myocardial fibrillar collagen content and causes diastolic dysfunction. ..
- Novel CATERPILLER gene involved in mucosal inflammationBeckley Davis; Fiscal Year: 2006..Biochemical analysis of 16.1/NOD27 has shown it to be a regulator of NF-K B dependent gene expression. These data suggest a role for 16.1/NOD27 in the inflammatory response associated with active colitis. ..
- Carbohydrate-carbohydrate interaction in basic cell biologySen itiroh Hakomori; Fiscal Year: 2006..abstract_text> ..
- Pancreatic Islets: From Development to TransplantationALVIN POWERS; Fiscal Year: 2005..This meeting will foster interactions of different scientific disciplines in an effort to address gaps in our knowledge about the pancreatic islet in health and disease. ..
- Planning a Multicenter Oral Itraconazole Trial in Chronic Rhinosinusitis PatientsHirohito Kita; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Regulation of Cellular Senescence by MEG3 RNAYunli Zhou; Fiscal Year: 2007..Therefore, another specific aim is to determine how MEGS activates p53. Whether MEG3 RNA activates p53 through repression of Mdm2 expression will be the focus of investigation. [unreadable] [unreadable] [unreadable] [unreadable]..
- Hepatoma derived growth factor and vascular smooth muscle cell proliferationAllen D Everett; Fiscal Year: 2010..We propose here to determine the mechanism regulating the activity of this protein to provide the basis for the future design of new drugs to treat cardiovascular disease. ..
- Models of P. carinii Infection: SP-A and SP-D null miceMichael Beers; Fiscal Year: 2009....
- Studies of a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)Ravi Salgia; Fiscal Year: 2011..Conduct an anti-c-Met phase I/I I clinical trial against NSCLC. Through the achievement of the goals proposed in these specific aims, we will arrive at novel therapy against c- Met in lung cancer. ..
- Prostaglandin Signaling in Wear Debris-induced OsteolysisREGIS O KEEFE; Fiscal Year: 2009....
- NEURAL REGULATION OF BONE REMODELINGWade Kingery; Fiscal Year: 2008..These investigations will help to identify the sensory transmitters that modulate bone remodeling and characterize their roles in osteoporotic processes. ..
- E. coli invasion of brain endothelial cellsKwang Kim; Fiscal Year: 2008..3.To determine the role of K1 capsule in E. coli trafficking in HBMEC. Further understanding and characterization of E. coli K1-HBMEC interactions should allow us to develop novel strategies to prevent this serious infection. ..
- CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MOBela Anand Apte; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Neurophysiology and Biomechanics of Urethra in Stress Urinary IncontinenceNaoki Yoshimura; Fiscal Year: 2008..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
- Antigen Presenting Cells in the Induction of GVHDYi Zhang; Fiscal Year: 2008..abstract_text> ..
- GLP-1 to Enhance Islet TransplantationALVIN POWERS; Fiscal Year: 2007..abstract_text> ..
- DIET AND SOMATIC MUTATIONS IN COLON CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 2007..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
- Aging-Cancer Research Program Development at CWRU CCCNathan Berger; Fiscal Year: 2007..abstract_text> ..
- BD Biosciences FACS Canto Flow CytometerLAWRENCE LAMB; Fiscal Year: 2006..The laboratory will require an instrument that will serve the laboratory in the development and execution of advanced cell therapy trials. [unreadable] [unreadable]..
- PHOSPHOLIPASE C GAMMA 1--BIOCHEMISTRY AND BIOLOGYGraham Carpenter; Fiscal Year: 2006..The result of these proposed experiments should significantly increase current understanding of how PLCgamma1 participates in growth factor-dependent mitogenesis. ..
- THE MUTAGENICITY OF MINERAL FIBERSTOM HEI; Fiscal Year: 2006..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
- TRANSCRIPTIONAL CONTROL OF TH2 CELL DIFFERENTIATIONWei Ping Zheng; Fiscal Year: 2004..It is proposed that knowledge gained from these studies will advance understanding and improve treatment of immunological diseases such as allergy and infection where Th2 responses are critical. ..
- PROTEOGLYCANS AND BRAIN DEVELOPMENTARTHUR LANDER; Fiscal Year: 2004..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
- PROSTACYCLIN SYNTHESIS IN PULMONARY HYPERTENSIONNorbert Voelkel; Fiscal Year: 2001..Lung endothelial cells and airway cells of rats also will be transfected with the PGI2 synthase gene and their response to hypoxia examined. ..
- Molecular Determinants of Vascularization in IsletsALVIN POWERS; Fiscal Year: 2003..We anticipate that information about islet revascularization from these studies will be directly relevant to transplantation in humans and will be useful in planning future interventions in humans. ..
- FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYMARTHA OR MARTY SLATTERY; Fiscal Year: 2003..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
- PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTORSenitiroh Hakomori; Fiscal Year: 2003..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..
- Lower urinary tract dysfunction in Parkinson's diseaseNaoki Yoshimura; Fiscal Year: 2003..This is a high priority in the urologic care of patients with Parkinson's disease. ..
- Human Kallikrein 4 (hK4): A New Prostatic Biomarker?Eleftherios Diamandis; Fiscal Year: 2003..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
- CO POISONING IN THE CONTEXT OF A REPERFUSION INJURYStephen Thom; Fiscal Year: 2003..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
- GP 120 MEDIATED ACTIVATION OF BRAIN ENDOTHELIAL CELLSKwang Kim; Fiscal Year: 2002..e., roles of G proteins and signaling pathways, platelet-activating factor (PAF). The information derived from this proposal should enhance our understanding of the role of HBMEC in HIV encephalopathy. ..
- REGULATION OF RETINAL NEOVASCULARIZATION BY TIMP3Bela Anand Apte; Fiscal Year: 2002..The broad long term goal of this proposal is to gain an understanding of the mechanism(s) by which alterations in matrix integrity may regulate retinal neovascularization using TIMP-3 mutations in SFD as a model. ..
- MOLECULAR ANALYSIS OF THE ALPHA6-BETA4 INTEGRINFilippo Giancotti; Fiscal Year: 2002..We hope that these studies will help to clarify the function of alpha6beta4 in normal and neoplastic cells. ..
- VIRAL AND IMMUNE RESPONSE TO THERAPY FOR HIV IN THE GALTAndrew Talal; Fiscal Year: 2003..This project amy provide important insights into the amount of time needed to treat HIV- infected individuals and may provide novel approaches by which to monitor therapeutic responses in these individuals. ..
- Role of IL-8 in Cell Migration and ProliferationIngrid Schraufstatter; Fiscal Year: 2004....
- Mechanisms of Growth Inhibition by Helicobacter PylorHassan Ashktorab; Fiscal Year: 2003..These studies will help to establish how bacteria can increase apoptosis possibly through generation of ROS and in specific circumstances this may alter one's risk of developing cancer. ..
- Primed Stroma: A Tumor Permissive MicroenvironmentEdna Cukierman; Fiscal Year: 2005..Developing therapeutic approaches focusing on containing cancer as a chronic and innocuous disease is our ultimate goal. ..
- Characterization of Ocular Neural Stem CellsIqbal Ahmad; Fiscal Year: 2004..abstract_text> ..
- Role of IL-18 and TNF-a in Necrotizing EnterocolitisBohuslav Dvorak; Fiscal Year: 2005..Data obtained from these studies will be used to determine the feasibility of pursuing anti-IL-18 or anti-TNF-alpha treatment in clinical trials. ..
- GORDON RESEARCH CONFERENCE ON PROTEOGLYCANSARTHUR LANDER; Fiscal Year: 2002....
- SPARC Modulates Extracellular Matrix Dynamics in SkinAMY BRADSHAW; Fiscal Year: 2004....
- DIFFERENTIATION OF GRANULOCYTES AND MACROPHAGESDonald Metcalf; Fiscal Year: 2004..abstract_text> ..
- Mice Overexpressing rtTA and Cre in Corneal EpitheliumWINSTON KAO; Fiscal Year: 2004..These mouse lines will be useful in preparing mouse lines for studies of altered genetic functions from the corneal epithelium-specific gene ablation and overexpression of reporter genes. ..
- Stem cell manipulation via HOX gene regulationStephen G Emerson; Fiscal Year: 2010..These experiments will describe in detail the role of NF-Y in the biology of hematopoietic stem cells, and will develop two experimental therapies based directly on the biology of NF-Y, for both HSC expansion and HSC differentiation. ..
- 2008 Musculoskeletal Biology and Bioengineering Gordon Research ConferenceFarshid Guilak; Fiscal Year: 2008..The meeting will consist of 9 separate sessions, consisting of invited speakers and selected attendees at various levels of career development. [unreadable] [unreadable] [unreadable] [unreadable]..
- AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAINNaoki Yoshimura; Fiscal Year: 2010..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
- Afferent modulation in bladde dysfunctionNaoki Yoshimura; Fiscal Year: 2007..abstract not provided ..
- A Novel Substrate of Src Tyrosine KinasesJohn Seykora; Fiscal Year: 2006..The rest of the applicant's effort, 15%, will involve diagnosing skin biopsies. ..
- Seasonal Plasticity of Brain and BehaviorLeah Pyter; Fiscal Year: 2005..3) To determine whether photoperiod also affects non-spatial learning and memory tasks. This research will provide insights into the mechanisms of seasonal plasticity of brain and behavior ..
- Training in Biomolecular and Tissue EngineeringFarshid Guilak; Fiscal Year: 2007..We will also take advantage of several long-standing and successful initiatives at Duke University to enhance the recruitment of underrepresented minorities as part of this post-doctoral training program. ..
- Mechanism of EGF-Mediated Reduction of NECBohuslav Dvorak; Fiscal Year: 2009..These studies will elucidate the mechanisms of EGF-mediated reduction of NEC, information that is essential to initiate use of EGF as a preventative or treatment modality for human NEC. ..
- Regulation of Human TLR3 & TLR9 Expression and FunctionSteven Young; Fiscal Year: 2004..Thus, the proposed studies will contribute to an understanding of mechanisms regulating human endometrial cytokine expression, which could lead to the design of pharmacologic therapies for both infectious and reproductive disorders. ..
- PLASMIN, FIBRIN, AND METALLOPROTEINASES IN LUNG FIBROSISThomas Sisson; Fiscal Year: 2004..The opportunities provided by the training program will provide the foundation for career advancement and hopefully lead to new therapies for fibrotic lung diseases. ..
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMMelanie Mediavilla Varela; Fiscal Year: 2008..These studies will provide insights into the mechanisms underlying prostate tumor resistance to cell death and lead to development of novel therapeutic strategies for PCa. [unreadable] [unreadable] [unreadable]..
- Ameloblastin Function in the Periodontal LigamentXianghong Luan; Fiscal Year: 2008..These studies might eventually lead to novel cures for gum diseases. [unreadable] [unreadable] [unreadable]..
- Regulation of osteoclastogenesis by TRANCEYongwon Choi; Fiscal Year: 2004....
- LEUCINE-RICH REPEAT PROTEIN LRRc17 AND OSTEOCLASTSYongwon Choi; Fiscal Year: 2009....