cyclin d1


Summary: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.

Top Publications

  1. pmc MicroRNA-193b represses cell proliferation and regulates cyclin D1 in melanoma
    Jiamin Chen
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Pathol 176:2520-9. 2010
  2. pmc The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    M Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:5522-7. 1999
  3. pmc MEK drives cyclin D1 hyperelevation during geroconversion
    O V Leontieva
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cell Death Differ 20:1241-9. 2013
  4. ncbi The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
    I Ben Sahra
    INSERM U568, Nice, France
    Oncogene 27:3576-86. 2008
  5. ncbi Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    O Tetsu
    University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143 0128, USA
    Nature 398:422-6. 1999
  6. ncbi Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
    Jiyong Liang
    Molecular and Cell Biology, Sunnybrook and Women s Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Cell Cycle 2:339-45. 2003
  7. pmc Nuclear cyclin D1: an oncogenic driver in human cancer
    Jong Kyong Kim
    Department of Cancer Biology, The Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Physiol 220:292-6. 2009
  8. pmc Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells
    Deborah A Greer Card
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 28:6426-38. 2008
  9. ncbi Minireview: Cyclin D1: normal and abnormal functions
    Maofu Fu
    Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057 1468, USA
    Endocrinology 145:5439-47. 2004
  10. ncbi p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    H Toyoshima
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037
    Cell 78:67-74. 1994

Detail Information

Publications384 found, 100 shown here

  1. pmc MicroRNA-193b represses cell proliferation and regulates cyclin D1 in melanoma
    Jiamin Chen
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Pathol 176:2520-9. 2010
    ..Eighteen of these down-regulated genes, including cyclin D1 (CCND1), were also identified as putative miR-193b targets by TargetScan...
  2. pmc The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    M Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:5522-7. 1999
    ..Here, we show that the cyclin D1 gene is a direct target for transactivation by the beta-catenin/LEF-1 pathway through a LEF-1 binding site in ..
  3. pmc MEK drives cyclin D1 hyperelevation during geroconversion
    O V Leontieva
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cell Death Differ 20:1241-9. 2013
    ..Hyperexpression of cyclin D1 is a universal marker of senescence along with hypertrophy, beta-Gal staining and loss of replicative/..
  4. ncbi The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
    I Ben Sahra
    INSERM U568, Nice, France
    Oncogene 27:3576-86. 2008
    ..This blockade was accompanied by a strong decrease of cyclin D1 protein level, pRb phosphorylation and an increase in p27(kip) protein expression...
  5. ncbi Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    O Tetsu
    University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143 0128, USA
    Nature 398:422-6. 1999
    ..Here we show that beta-catenin activates transcription from the cyclin D1 promoter, and that sequences within the promoter that are related to consensus TCF/LEF-binding sites are ..
  6. ncbi Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
    Jiyong Liang
    Molecular and Cell Biology, Sunnybrook and Women s Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Cell Cycle 2:339-45. 2003
    ..that positively regulates G1/S cell cycle progression through inactivation of GSK3-beta, leading to increased cyclin D1, and inhibition of Forkhead family transcription factors and the tumor suppressor tuberin (TSC2), leading to ..
  7. pmc Nuclear cyclin D1: an oncogenic driver in human cancer
    Jong Kyong Kim
    Department of Cancer Biology, The Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Physiol 220:292-6. 2009
    Perturbations in the regulation of the core cell cycle machinery are frequently observed in human cancers. Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell ..
  8. pmc Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells
    Deborah A Greer Card
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 28:6426-38. 2008
    ..Moreover, we show that miR-302a represses the productive translation of an important G(1) regulator, cyclin D1, in hESCs...
  9. ncbi Minireview: Cyclin D1: normal and abnormal functions
    Maofu Fu
    Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057 1468, USA
    Endocrinology 145:5439-47. 2004
    b>Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle...
  10. ncbi p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    H Toyoshima
    Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, California 92037
    Cell 78:67-74. 1994
    Using a yeast interaction screen to search for proteins that interact with cyclin D1-Cdk4, we identified a 27 kDa mouse protein related to the p21 cyclin-Cdk inhibitor...
  11. pmc A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
    Zuoren Yu
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Cell Biol 182:509-17. 2008
    ..Herein, levels of the miR-17-5p/miR-20a miRNA cluster were inversely correlated to cyclin D1 abundance in human breast tumors and cell lines...
  12. pmc The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention
    John P Alao
    Department of Cell and Molecular Biology, Lundberg Laboratory, Gothenburg University, Gothenburg, Sweden
    Mol Cancer 6:24. 2007
    b>Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the development and progression of cancer...
  13. ncbi Cyclin D-dependent kinases, INK4 inhibitors and cancer
    Sagrario Ortega
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Biochim Biophys Acta 1602:73-87. 2002
    ..of human tumors by genetic and epigenetic alterations that target at least some of its key members such as Cyclin D1, Cdk4, INK4a and INK4b, pRb etc...
  14. pmc A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer
    Jerome Eeckhoute
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 20:2513-26. 2006
    ..type of human breast cancer that expresses estrogen receptor alpha (ERalpha) through the activation of the cyclin D1 (CCND1) oncogene. However, our knowledge of ERalpha transcriptional mechanisms remains limited...
  15. ncbi MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth
    Julia Schultz
    Department of Dermatology and Venereology, University of Rostock, 18055 Rostock, Germany
    Cell Res 18:549-57. 2008
    ..targeting of 3'-untranslated regions (3'UTRs) of individual mRNAs, as exemplified by reporter gene analyses for cyclin D1. In line with its downmodulating effects on cell cycle regulators, let-7b inhibited cell cycle progression and ..
  16. pmc microRNA-9 suppresses the proliferation, invasion and metastasis of gastric cancer cells through targeting cyclin D1 and Ets1
    Liduan Zheng
    Department of Pathology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
    PLoS ONE 8:e55719. 2013
    ..In this study, miR-9 was found to be down-regulated and inversely correlated with the expression of cyclin D1 and v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) in gastric cancer tissues and cell lines...
  17. ncbi MicroRNA-155 inhibits proliferation and migration of human extravillous trophoblast derived HTR-8/SVneo cells via down-regulating cyclin D1
    Y Dai
    Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China
    Placenta 33:824-9. 2012
    ..Bioinformatics analysis showed that, at the 3' untranslated region (UTR) of cyclin D1, six bases are complementary to the seed region of miR-155...
  18. ncbi Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    D E Cressman
    Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
    Science 274:1379-83. 1996
    ..of STAT3 (signal transducer and activator of transcription protein 3) activation and depressed AP-1, Myc, and cyclin D1 expression...
  19. ncbi AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
    Joseph F Gera
    Department of Medicine, West Los Angeles Veteran s Administration UCLA Medical Center, University of California School of Medicine, Los Angeles, California 90073, USA
    J Biol Chem 279:2737-46. 2004
    ..The analysis also allowed the assessment of steady-state transcript levels. We identified two transcripts, cyclin D1 and c-myc, which exhibited differential expression in an AKT-dependent manner: High levels of activated AKT ..
  20. pmc Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen
    Frédéric Bienvenu
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 463:374-8. 2010
    b>Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed in human cancers. The full repertoire of cyclin D1 functions in normal development and oncogenesis is unclear at present...
  21. ncbi Cyclin E and survival in patients with breast cancer
    Khandan Keyomarsi
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston 77030 4095, USA
    N Engl J Med 347:1566-75. 2002
    ..Cyclin E, a regulator of the cell cycle, affects the behavior of breast-cancer cells. We investigated whether levels of cyclin E in the tumor correlated with survival among patients with breast cancer...
  22. ncbi microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2
    Jing Nie
    Department of Molecular Biology, PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
    Carcinogenesis 33:220-5. 2012
    ..and indicated that the antitumor effects of miR-365 were probably mediated by its targeting and repression of Cyclin D1 and Bcl-2 expression, thus inhibiting cell cycle progression and promoting apoptosis...
  23. pmc Suppression of cancer cell growth by promoting cyclin D1 degradation
    Jing Shan
    Institute for Cancer Genetics and Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Mol Cell 36:469-76. 2009
    The cyclin D1 proto-oncoprotein is a crucial regulator in cell-cycle progression, and aberrant overexpression of cyclin D1 is linked to tumorigenesis of many different cancer types...
  24. ncbi GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cell Signal 20:581-9. 2008
    b>Cyclin D1 is known as a proto-oncogene whose gene amplification and protein overexpression are frequently observed in tumor cells...
  25. ncbi Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters
    Sebastián Giulianelli
    Institute of Experimental Biology and Medicine, IBYME CONICET, Buenos Aires, Argentina
    Cancer Res 72:2416-27. 2012
    ..ERα blockade also prevented an MPA-induced increase in CYCLIN D1 (CCND1) and MYC expression...
  26. pmc Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1
    J Lian
    Hefei National Laboratory for Physical Sciences, Microscale and School of Life Sciences, University of Science and Technology of China, Anhui, China
    Cell Death Dis 1:e94. 2010
    ..IRF1 by affecting its mRNA stability, which subsequently reduced the levels of the targets of IRF1, namely cyclin D1, CDK2 and p21...
  27. ncbi Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer
    Hui Wen Lo
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:338-48. 2005
    ..While localized in the nucleus, EGFR functions as a transcriptional regulator resulting in the activation of the cyclin D1 gene...
  28. ncbi Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1
    Masumi Suzui
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 62:3997-4006. 2002
    ..decreased levels of the hyperphosphorylated form of the retinoblastoma protein, and decreased levels of cyclin D1, but no significant changes were seen in the levels of the p16(INK4a), p27(KIP1), cyclin-dependent kinase 4, ..
  29. pmc MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells
    Xiaomei Qin
    Key Laboratory of Molecular Cardiovascular Science, Peking University Health Science Center, Beijing 100191, China
    Proc Natl Acad Sci U S A 107:3240-4. 2010
    ..gene controlled by a conserved 3'-untranslated region of the cyclinD1 gene and also the protein level of cyclin D1, leading to an arrest of cell cycle at G1/S transition...
  30. pmc Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex
    Douglas I Lin
    The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell 24:355-66. 2006
    Growth factor-dependent accumulation of the cyclin D1 proto-oncogene is balanced by its rapid phosphorylation-dependent proteolysis...
  31. ncbi Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells
    Junyu Wang
    Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, No 415 Fengyang Road, Shanghai, 200003, People s Republic of China
    J Neurooncol 106:473-84. 2012
    Elevated cyclin D1 (CCND1) in human glioblastoma correlates with poor clinical prognosis...
  32. ncbi Cycling to cancer with cyclin D1
    J Alan Diehl
    The Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Department of Cancer Biology, Philadelphia, Pennsylvania 19104 USA
    Cancer Biol Ther 1:226-31. 2002
    ..the G(1) phase of the cell cycle occur frequently in human cancer and overexpression of the G(1) phase cyclin, cyclin D1, is one of the most commonly observed alterations...
  33. ncbi MicroRNA-16 inhibits bladder cancer proliferation by targeting Cyclin D1
    Qi Quan Jiang
    Department of Urology, Affiliated Tongji Hospital, Tongji University, Shanghai, China
    Asian Pac J Cancer Prev 14:4127-30. 2013
    ..At the molecular level, our results further revealed that cyclin D1 expression was negatively regulated by miR-16...
  34. ncbi Clinicopathological and prognostic role of cyclin D1 in esophageal squamous cell carcinoma: a meta-analysis
    J Zhao
    The Third Affiliated Hospital of Guangzhou Medical College, Department of Cardiothoracic Surgery, Guangzhou, China
    Dis Esophagus 25:520-6. 2012
    b>Cyclin D1 is one of the most commonly over-expressed oncogenes; however, its role in esophageal squamous cell carcinoma (ESCC) remains controversial...
  35. pmc MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/cyclin D1 signaling
    Vien Khach Lai
    Department of Pathology, University of Cincinnati, Cincinnati, OH, USA
    Cell Cycle 11:767-77. 2012
    ..of FoxO1, which activated Erk5, a distinct mitogen-induced MAPK that drove transcriptional activation of cyclin D1 and Cdk4...
  36. pmc Cyclin D1 downregulation is important for permanent cell cycle exit and initiation of differentiation induced by anchorage-deprivation in human keratinocytes
    Kayoko Nishi
    Department of Environmental Toxicology, School of Agricultural Sciences, University of California Davis, Davis, California 95616, USA
    J Cell Biochem 106:63-72. 2009
    ..In accordance, cyclin D1, a positive regulator of cyclin-dependent kinase (CDK) 4/6 which phosphorylates RB decreased drastically in ..
  37. pmc A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration
    Raymond Ng
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, California 94143, USA
    J Clin Invest 122:1097-108. 2012
    ..impaired progression of hepatocytes into S phase of the cell cycle, mainly through a decrease in levels of cyclin D1 protein, but not Ccnd1 mRNA...
  38. pmc MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin D1 and cyclin E1
    Wang Hui
    Department of Neurosurgery, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    PLoS ONE 8:e54932. 2013
    ..Moreover, we show that miR-195 inhibited glioma cell proliferation by downregulating expression of cyclin D1 and cyclin E1, via directly targeting the 3'-untranslated regions (3'-UTR) of cyclin D1 and cyclin E1 mRNA...
  39. pmc FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma
    Qing Liu
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    Clin Cancer Res 16:3182-92. 2010
    ..Because of the absence of curative therapy for MCL, we explored FTY720 as a novel agent against MCL...
  40. pmc Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer
    Yoku Hayakawa
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Proc Natl Acad Sci U S A 108:780-5. 2011
    ..siRNA inhibited cell proliferation through the accumulation of cells in G1 phase of the cell cycle, and reduced cyclin D1 expression in gastric cancer cells, whereas these effects were uncommon in other cancer cells...
  41. ncbi Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line
    Hector Biliran
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 11:6075-86. 2005
    Elevated cyclin D1 in human pancreatic cancer correlates with poor prognosis...
  42. ncbi Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter
    Sung Gyoo Park
    School of Biological Sciences, Institute of Microbiology, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 281:31770-7. 2006
    b>Cyclin D1 is frequently overexpressed in hepatocellular carcinoma (HCC) exhibiting increased malignant phenotypes. It has also been known that the hepatitis Bx (HBx) protein is strongly associated with HCC development and progression...
  43. ncbi Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
    T C Wang
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    Nature 369:669-71. 1994
    ..b>Cyclin D1 was identified as a candidate oncogene (PRAD1) in tumour-specific DNA rearrangements and is suspected to be a ..
  44. pmc Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1
    G M Wulf
    Cancer Biology Program, Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 20:3459-72. 2001
    ..Here we report that Pin1 is strikingly overexpressed in human breast cancers, and that its levels correlate with cyclin D1 levels in tumors. Overexpression of Pin1 increases cellular cyclin D1 protein and activates its promoter...
  45. ncbi Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3β-Cyclin D1 pathway
    Chye Sun Ong
    School of Chemical and Life Sciences, Singapore Polytechnic, Singapore 139651, Republic of Singapore
    Cancer Lett 298:167-75. 2010
    ..Next, it was found that luteolin treatment led to down-regulation of cyclin D1 via enhanced protein phosphorylation and proteasomal degradation, leading to reduced CDK4/6 activity and ..
  46. ncbi Cyclin D1: polymorphism, aberrant splicing and cancer risk
    K E Knudsen
    Department of Cell Biology, University of Cincinnati, Cincinnati, OH 45267, USA
    Oncogene 25:1620-8. 2006
    The cyclin D1 proto-oncogene exercises powerful control over the mechanisms that regulate the mitotic cell cycle, and excessive cyclin D1 expression and/or activity is common in human cancers...
  47. ncbi Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma
    Victor Y Yazbeck
    Department of Lymphoma Myeloma, The University of Texas M D Anderson Cancer Center, Houston, Tex 77030, USA
    Exp Hematol 36:443-50. 2008
    ..To investigate the mechanisms of antiproliferative effect induced by the mammalian target of rapamycin (mTOR) inhibitor temsirolimus in mantle cell lymphoma (MCL)...
  48. ncbi Prognostic relevance of gene amplifications and coamplifications in breast cancer
    Khawla Al-Kuraya
    King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Cancer Res 64:8534-40. 2004
    ..In conclusion, these data support a major prognostic impact of genomic instability as determined by a broad gene amplification survey in breast cancer...
  49. pmc Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition
    Jakob Mejlvang
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE1 9HN, United Kingdom
    Mol Biol Cell 18:4615-24. 2007
    ..We found that concomitant with inducing invasive phenotype, SIP1 inhibited expression of cyclin D1 and induced hypophosphorylation of the Rb tumor suppressor protein...
  50. pmc The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
    Guang Hui Xiao
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 25:2384-94. 2005
    ..tumor cells inhibits cell proliferation and arrests cells at G1 phase, concomitant with decreased expression of cyclin D1, inhibition of CDK4 activity, and dephosphorylation of pRB...
  51. pmc PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling
    Ensar Halilovic
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Res 70:6804-14. 2010
    ..We show that PD0325901, a small-molecule MEK inhibitor, decreases MEK/ERK pathway signaling and destabilizes cyclin D1, resulting in significant anticancer activity in a subset of KRAS mutant tumors in vitro and in vivo...
  52. pmc Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 t
    Luigi Cicatiello
    Dipartimento di Patologia Generale, Seconda Universita degli Studi di Napoli, 80138 Naples, Italy
    Mol Cell Biol 24:7260-74. 2004
    Transcriptional activation of the cyclin D1 gene (CCND1) plays a pivotal role in G(1)-phase progression, which is thereby controlled by multiple regulatory factors, including nuclear receptors (NRs)...
  53. ncbi Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells
    Chioniso Patience Masamha
    Departments of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Cancer Res 69:6565-72. 2009
    ..b>Cyclin D1 is often overexpressed in a variety of cancers and is associated with tumorigenesis and metastasis...
  54. pmc Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo
    Nathalie Fiaschi-Taesch
    Division of Endocrinology, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes 58:882-93. 2009
  55. pmc A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
    Hiroshi Okabe
    Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, California, United States of America UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 1:e128. 2006
    b>Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear...
  56. ncbi Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    Muneyuki Masuda
    Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, HHSC 1509, New York, New York 10032, USA
    Cancer Res 62:3351-5. 2002
    ..and activators of transcription 3 (Stat3) is often activated in HNSCC cells, we examined the effects of Stat3 on cyclin D1 expression and cell proliferation in the YCU-H891 HNSCC cell line that displays constitutive activation of Stat3...
  57. pmc c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 235:18-24. 2009
    ..Furthermore, our data indicated that cyclin D1 was an important downstream molecule involved in c-Jun/AP-1-mediated cell transformation upon low dose arsenite ..
  58. ncbi Growth stimulation leads to cellular senescence when the cell cycle is blocked
    Zoya N Demidenko
    Oncotarget, Albany, New York, USA
    Cell Cycle 7:3355-61. 2008
    ..of p21 caused senescence, characterized by beta-Galactosidase staining, cell hypertrophy, increased levels of cyclin D1 and active TOR (target of rapamycin, also known as mTOR)...
  59. pmc Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
    Gaurav Das
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Neural Dev 4:15. 2009
    ..The cell cycle regulator cyclin D1 is expressed in RPCs, and mice with a targeted null allele at the cyclin D1 locus (Ccnd1-/-) have microphthalmia ..
  60. ncbi Altered expression of DACH1 and cyclin D1 in endometrial cancer
    Fangfang Nan
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, China
    Cancer Biol Ther 8:1534-9. 2009
    ..DACH1 inhibits breast cancer cellular proliferation via cyclin D1. Endometrial cancer is the third most common cancer in women and broad screening for DACH1 expression will ..
  61. pmc Increased mitogen-activated protein kinase kinase/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3',5'-cyclic adenosine 5'-monophosphate inhibition of cyclin D1
    Michael C Velarde
    Department of Obstetrics, Center for Reproductive Sciences, University of California San Francisco, San Francisco, California 94143 0132, USA
    Endocrinology 150:4701-12. 2009
    ..Here, we demonstrate that 8-Br-cAMP inhibits bromodeoxyuridine incorporation and cyclin D1 (CCND1) expression in cultured human endometrial stromal fibroblasts (hESF) from women without but not with ..
  62. ncbi Cyclin D1 G870A polymorphism and breast cancer risk: a meta-analysis comprising 9,911 cases and 11,171 controls
    Theodoros N Sergentanis
    School of Medicine, National University of Athens, Athens, Greece
    Mol Biol Rep 38:4955-63. 2011
    b>Cyclin D1 represents a key molecule in the regulation of cell cycle. CCND1 G870A (rs603965) polymorphism has drawn considerable attention as the A allele may generate a variant splice product with possible oncogenic actions...
  63. ncbi Acquired radioresistance of cancer and the AKT/GSK3β/cyclin D1 overexpression cycle
    Tsutomu Shimura
    Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Radiat Res 52:539-44. 2011
    ..The acquired radioresistance was associated with overexpression of cyclin D1, a result of a series of molecular changes; constitutive activation of DNA-PK and AKT with concomitant down-..
  64. ncbi Up-regulation of enhancer of zeste homolog 2 is associated positively with cyclin D1 overexpression and poor clinical outcome in head and neck squamous cell carcinoma
    Wei Cao
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer 118:2858-71. 2012
    ..In the current study, they investigated whether EZH2 can function as a prognostic predictor for patients with head and neck squamous cell carcinoma (HNSCC)...
  65. pmc MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and cyclin D1
    Weiying Zhang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People s Republic of China
    PLoS ONE 7:e31450. 2012
    ..Further studies revealed that the mitogen-activated protein kinase kinase kinase 2 (MEKK2) and cyclin D1 were two of direct target genes of miR-520b...
  66. pmc NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition
    M Hinz
    Molekulare Zellbiologie, Humboldt Universitat zu Berlin, Max Delbrück Haus, 13122 Berlin, Germany
    Mol Cell Biol 19:2690-8. 1999
    ..NF-kappaB was found to stimulate transcription of cyclin D1, a key regulator of G1 checkpoint control...
  67. pmc Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway
    Rachna Kaul
    Biochemistry Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    J Biol Chem 287:19750-64. 2012
    ..supported by activation of MAP kinase and AKT-mediated cell survival pathways, which leads to an increase in CYCLIN D1 promoter activity...
  68. pmc Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study
    Katja Lundgren
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Breast Cancer Res 14:R57. 2012
    ..of CCND1 is observed in a subgroup of breast cancers with poor prognosis, whereas overexpression of the protein cyclin D1 has been linked to both worse and better clinical outcome...
  69. ncbi Evidence for cell cycle suppression and microRNA regulation of cyclin D1 during anoxia exposure in turtles
    Kyle K Biggar
    Institute of Biochemistry and Department of Biology, Carleton University, Ottawa, ON, Canada
    Cell Cycle 11:1705-13. 2012
    ..b>Cyclin D1 is a critical regulator of the G 1 phase of the cell cycle and is regarded as key to initiating cell ..
  70. pmc Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element
    Marilena Lanzino
    Dipartimento Farmaco Biologico, University of Calabria, Arcavacata di Rende CS 87036, Italy
    Nucleic Acids Res 38:5351-65. 2010
    b>Cyclin D1 gene (CCND1) is a critical mitogen-regulated cell-cycle control element whose transcriptional modulation plays a crucial role in breast cancer growth and progression...
  71. pmc Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma
    Daniel Ciznadija
    Program in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 71:6174-83. 2011
    ..p21 contributes to gliomagenesis by stabilizing cyclin D1-cdk4 kinase complexes, suggesting that cyclin D1 and cdk4 may also be required for glial tumor development...
  72. ncbi Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients
    T Zhang
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 57:169-75. 1997
    We postulated that increased expression of the cell cycle regulators cyclin D1 and cyclin-dependent kinase (Cdk) 4 may be involved in the development of intestinal adenomas associated with familial adenomatous polyposis (FAP)...
  73. pmc Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways
    Zheng Li
    Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
    PLoS ONE 7:e53176. 2012
    ..Mechanistically, leptin induced the phosphorylation of STAT3, Akt and ERK1/2 accompanied by the upregulation of cyclin D1. Pharmacological inhibition of JAK/STAT3, PI3K/Akt or MEK/ERK signaling by AG490, Wortmannin or U0126, ..
  74. pmc Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells
    Chi Man Tsang
    Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong
    Proc Natl Acad Sci U S A 109:E3473-82. 2012
    ..Genetic alterations leading to activation of cyclin D1 signaling in premalignant nasopharyngeal epithelial (NPE) cells have been postulated to predispose cells to EBV ..
  75. pmc Activation of the Wnt signaling pathway in chronic lymphocytic leukemia
    Desheng Lu
    Rebecca and John Moores UCSD Cancer Center, University of California at San Diego, La Jolla, CA 92093 0663, USA
    Proc Natl Acad Sci U S A 101:3118-23. 2004
    ..the Wnt/beta-catenin-regulated transcription factor lymphoid-enhancing factor-1, and its downstream target cyclin D1, were overexpressed in CLL...
  76. ncbi The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis
    Chiara Pellegrini
    Department of Gynecology, Obstetrics and Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland
    Fertil Steril 98:1200-8. 2012
    To analyze the expression of estrogen receptors α and β as well as their target genes implicated in proliferation, c-myc, cyclin D1, and GREB1, in the endometrium of women with or without endometriosis.
  77. pmc Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report
    Gabriella Aquino
    Pathology Unit, National Cancer Institute Fondazione Giovanni Pascale, Via Mariano Semmola, 80131 Napoli, Italy
    Diagn Pathol 7:79. 2012
    ..We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in mantle cell ..
  78. ncbi Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway
    Kuniko Nakajima
    Mitsubishi Kagaku Institute of Life Sciences, Machida 194 8511, Japan
    Development 138:1771-82. 2011
    ..on abnormal phenotypes, such as hyperproliferation, inhibition of differentiation and enhanced expression of cyclin D1 in cardiomyocytes of mice with mutant jumonji (Jmj, Jarid2), which encodes the repressor of cyclin D1...
  79. pmc Reviewing once more the c-myc and Ras collaboration: converging at the cyclin D1-CDK4 complex and challenging basic concepts of cancer biology
    Chenguang Wang
    Department of Stem Cell and Regenerative Medicine, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:57-67. 2011
    ..In many cases, these collaborations may converge at the cyclin D1-CDK4 complex...
  80. pmc Cyclin D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling
    Manjula Karpurapu
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 285:3510-23. 2010
    Platelet-derived growth factor BB induced cyclin D1 expression in a time- and nuclear factor of activated T cells (NFAT)-dependent manner in human aortic smooth muscle cells (HASMCs), and blockade of NFATs prevented HASMC DNA synthesis ..
  81. ncbi Evaluation of immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 in oral and oropharyngeal squamous cell carcinoma
    Christos Perisanidis
    Department of Cranio, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria
    J Oral Pathol Med 41:40-6. 2012
    The purpose of this study was to evaluate whether the immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 can predict therapy response and survival in patients with oral and oropharyngeal squamous cell carcinoma treated ..
  82. ncbi Targeted disruption of S100P suppresses tumor cell growth by down-regulation of cyclin D1 and CDK2 in human hepatocellular carcinoma
    Jeong Kyu Kim
    Department of Pathology, Microdissection Genomics Research Center, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
    Int J Oncol 35:1257-64. 2009
    ..The aberrant regulation of S100P in HCC might activate cyclin D1 and CDK expression and contribute to the mitogenic potential of tumor cells during HCC carcinogenesis...
  83. pmc The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression
    Yong Jin Yang
    College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi do 440 746, Republic of Korea
    Nucleic Acids Res 38:382-90. 2010
    ..Parafibromin induces cell cycle arrest by repressing cyclin D1 via an unknown mechanism...
  84. pmc The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers
    Elodie E Noel
    Medical Oncology Centre, Cancer Institute, Barts and London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Am J Pathol 176:2607-15. 2010
    ..CCND1 could be potentially used as a marker for treatment stratification and as a molecular target to improve the treatment of platinum-resistant tumors...
  85. pmc Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α
    Eric A Hanse
    Division of Gastroenterology, Hennepin County Medical Center, Minneapolis, MN, USA
    Cell Cycle 11:2681-90. 2012
    ..In this study, we examined the regulation of de novo lipogenesis by cyclin D1, a key mediator of hepatocyte cell cycle progression...
  86. ncbi Cyclin D1 induction of cellular migration requires p27(KIP1)
    Zhiping Li
    Kimmel Cancer Center, Departments of Cancer Biology and Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 66:9986-94. 2006
    The cyclin D1 gene is amplified and overexpressed in human breast cancer, functioning as a collaborative oncogene...
  87. ncbi Synergistic effect of cyclin D1 and c-Myc leads to more aggressive and invasive mammary tumors in severe combined immunodeficient mice
    Yong Wang
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Hudson Webber Cancer Research Center, Wayne State University School of Medicine, Detroit, MI, USA
    Cancer Res 67:3698-707. 2007
    b>Cyclin D1 is one of the most commonly overexpressed oncogenes in breast cancer; yet, it is not clear whether cyclin D1 alone is capable of causing malignant transformation of mammary epithelial cells...
  88. pmc Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68
    Maria Paola Paronetto
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
    Cancer Res 70:229-39. 2010
    Human cyclin D1 is expressed as two isoforms derived by alternate RNA splicing, termed D1a and D1b, which differ for the inclusion of intron 4 in the D1b mRNA...
  89. pmc Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis
    Rinath Jeselsohn
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
    Cancer Cell 17:65-76. 2010
    ..b>Cyclin D1 is required for lobuloalveolar development during pregnancy and lactation as well as MMTV-ErbB2- but not MMTV-..
  90. ncbi Regulation of cyclin D1 gene expression
    Ini Isabée Witzel
    Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Biochem Soc Trans 38:217-22. 2010
    b>Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation...
  91. ncbi Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner
    Tathagata Choudhuri
    Bose Institute, P 1 12 Calcutta Improvement Trust Scheme VII M, Kolkata, India
    J Biol Chem 280:20059-68. 2005
    ..microscopy, we have demonstrated that curcumin induces apoptosis at G(2) phase of cell cycle in deregulated cyclin D1-expressed mammary epithelial carcinoma cells, leaving its normal counterpart unaffected...
  92. pmc A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
    Siwanon Jirawatnotai
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 474:230-4. 2011
    b>Cyclin D1 is a component of the core cell cycle machinery. Abnormally high levels of cyclin D1 are detected in many human cancer types...
  93. pmc Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening
    Eric A Klein
    Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 19:1511-8. 2009
    ..In this report, we use hydrogel-based substrata matched to biological tissue stiffness to investigate the effects of matrix elasticity on the cell cycle...
  94. pmc Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
    S S Kwek
    Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Oncogene 28:1892-903. 2009
  95. ncbi Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation
    Oliver Gautschi
    University of California Davis Cancer Center, Sacramento 95817, USA, and Clinic of Medical Oncology, University Hospital Bern, Bern, Switzerland
    Lung Cancer 55:1-14. 2007
    To review the evidence implicating the deregulation of cyclin D1 in the pathogenesis of non-small cell lung cancer (NSCLC), and to discuss the opportunities for targeted clinical intervention.
  96. pmc Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation
    Yuxia Zhang
    Department of Medicine and Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA
    Hepatology 48:289-98. 2008
    ..carcinoma, which was found to be strongly associated with enhanced hepatocyte proliferation and increased cyclin D1 expression. In contrast, overexpressing SHP in hepatocytes of SHP-transgenic mice reversed this effect...
  97. ncbi PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model
    L P Weng
    Clinical Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 10:599-604. 2001
    ..the blockade of cell cycle progression, an increase in the abundance of p27, a decrease in the protein levels of cyclin D1 and the inhibition of Akt phosphorylation...
  98. pmc The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation
    Latha Shivakumar
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Mol Cell Biol 22:4309-18. 2002
    ..RASSF1A inhibits accumulation of native cyclin D1, and the RASSF1A-induced cell cycle arrest can be relieved by ectopic expression of cyclin D1 or of other ..
  99. ncbi In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00
    Kalpana S Joshi
    Department of Pharmacology, Nicholas Piramal Research Center, Nicholas Piramal India Limited, 1 Nirlon Complex, Goregaon E, Mumbai 400 063, India
    Mol Cancer Ther 6:918-25. 2007
    ..A significant down-regulation of cyclin D1 and Cdk4 and a decrease in Cdk4-specific pRb Ser(780) phosphorylation was observed...
  100. ncbi Advances in the understanding of mantle cell lymphoma
    Pedro Jares
    Haematopathology Section, Laboratory of Pathology, and Genomics Unit, Hospital Clinic, Institut de Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Br J Haematol 142:149-65. 2008
    ..The genetic hallmark is the t(11;14)(q13;q32) translocation leading to the overexpression of cyclin D1, which is considered the initial oncogenic event...
  101. ncbi Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways
    Birgitte N Friedrichsen
    Novo Nordisk A S, Department of Islet Discovery Research, Krogshoejvej 31, 9R2 28, 2880 Bagsvaerd, Denmark
    J Endocrinol 188:481-92. 2006
    ..GLP-1 time-dependently induced the cyclin D1 mRNA and protein levels in INS-1E, whereas the cyclin D2 levels were unaffected...

Research Grants70

  1. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..We will determine in vitro and in vivo whether specific proteins that regulate the cell cycle machinery (cyclin D1/D3, CDK4) and/or apoptosis (p53) are subject to translational regulation by TRM9...
  2. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..and an activation of the p53 tumor suppressor and inactivating the Stat3 oncogenic signaling, associated with cyclin D1 (cell cycle) and Bcl-xL/Mcl-1 (cell survival) down regulation...
  3. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2013
    ..a multiprotein complex that modulates the actin cytoskeleton, increases cell motility and invasiveness, mediates cyclin D1 gene transcription and affects tumorigenicity of human breast cancer cells...
  4. Iron-Induced Changes in Liver That Predispose to Malignancy
    Harriet C Isom; Fiscal Year: 2010
    ..Iron overload, using TMHF as an iron donor, induced cyclin D1 expression, PCNA labeling index and hepatomegaly confirming similar findings in mice in which different iron ..
  5. NADPH oxidase-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2013
    ..In addition, ROS may upregulate cyclin D1 and the silencer of the death domain (SODD)...
  6. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    ..characteristic of mammary glands and aortae acts as a cell cycle inhibitor through a selective effect on cyclin D1. The compliance-regulated signaling pathway involves FAK, but is distinguishable from the signaling pathways ..
  7. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2012
    ..FIP200 inhibited cell cycle progression through its regulation of the cyclin dependent kinase inhibitor p21 and cyclin D1 in breast cancer cells...
    DEBRA LYNN LASKIN; Fiscal Year: 2012
    ..Down-regulation of Cav-1 after ozone inhalation is associated with activation of the (-catenin/cyclin D1 pro-mitogenic signaling pathway...
    Lorraine J Gudas; Fiscal Year: 2013
    ..g. p16, cyclin D1, cyclooxygenase-2, EGFR, phosphoSTAT3, and cell proliferation (BrdU or PCNA)...
  10. IKKbeta:Bi-Functional Regulator of Hepatocyte Proliferation
    Hyam L Leffert; Fiscal Year: 2010
    ..Proto-oncogene cyclin D1 is a major cell-cycle protein that is necessary for normal adult hepatocyte proliferation...
  11. Heat shock protein 90 antagonist-based therapy of mantle cell lymphoma
    Kapil Bhalla; Fiscal Year: 2012
    ..demonstrated that treatment with GAA depleted the levels of the hsp90 client proteins CDK4, c-Raf, AKT and cyclin D1, which confer growth and survival advantage on MCL cells...
  12. USC Research Center for Liver Disease
    Neil Kaplowitz; Fiscal Year: 2013
    ..X receptor, bile acids and liver regeneration;b) the role of Myc-max and Mnt-max in regulation of p53 and cyclin D1 by toxic bile acid;c) salvage of short bowel syndrome by tissue engineered intestine;d) development of a model ..
  13. Diet and Alcohol Induced Epigenetic Changes in Oral Cavity Carcinogenesis Model
    Lorraine J Gudas; Fiscal Year: 2013
    ..cancer in our murine oral cavity carcinogenesis model, and to assess the expression of molecular markers such as cyclin D1;RAR22;p16;SFRP 1,2,4, and 5;and nanog in normal epithelial stem/progenitor cells versus "cancer stem/progenitor ..
  14. Dietary Regulation of Pancreatic Digestive Enzymes
    John A Williams; Fiscal Year: 2013
    ..AP-1 (activated by MAP kinases) with particular attention to regulation of cell-cycle regulating genes such as cyclin D1 and PCNA and to endogenous feedback inhibitors such as MClP1 for calcineurin...
  15. Thyroid hormone-dependent DNA methylation in the developing brain
    Yasuhiro Kyono; Fiscal Year: 2012
    ..Several lines of evidence support that cyclin D1 is directly regulated by DNMT3a-mediated DNA methylation...
  16. Cell Cycle Pathways and Spinal Cord Injury
    ALAN IRA FADEN; Fiscal Year: 2011
    ..SCI causes increased expression of critical cell cycle related genes/proteins (including c-myc, cyclin D1, CDK4, Rb and E2F5) and activation of cell cycle pathways (activation of CDKs and phosphorylation of Rb) in ..
  17. Molecular mechanisms of C/EBP alpha mediated growth arrest
    Nikolai A Timchenko; Fiscal Year: 2013
    ..These complexes occupy the promoters of cyclin D1 and D2...
  18. Stat3 in Epitherlial Carcinogenesis
    John DiGiovanni; Fiscal Year: 2012
    ..e., cyclin D1) in bulge region KSCs during tumor promotion by TPA and UVB and 4) to further explore genes regulated by Stat3 ..
  19. Chimaerins-receptors for diacylgly and phorbal esters
    ..including actin cytoskeleton reorganization, migration, invasion, proliferation, cell cycle progression, and cyclin D1 induction in response to ErbB receptor ligands, including EGF and heregulin...
  20. Small Interfering RNAs: Inhibition of Oral Carcinogenesis in a Mouse Model
    Lorraine J Gudas; Fiscal Year: 2010
    ..Because both cyclooxygenase 2 (Cox-2) and cyclin D1 proteins are overexpressed in human oral cancer and inhibition of their expression suppresses the proliferation ..
  21. Akt/mTOR Signaling in Energy Balance Modulation of Epithelial Carcinogenesis
    Stephen D Hursting; Fiscal Year: 2013
    ..Furthermore, we have found that CR reduces cyclin D1 and increases p27 levels in epidermis...
  22. Regulation of Genomic Instability in Early Breast Cancer
    Thea D Tlsty; Fiscal Year: 2013
    ..e pRb, cyclin D1 and Cdk4, (2) to determine if the program of acquired DNA methylation events that accompanies the loss of ..
  23. NFATs and Vascular Injury
    Gadiparthi N Rao; Fiscal Year: 2013
    ..Cyclins such as cyclin D1 and cyclin A2 and proinflammatory cytokines such as IL-6 appear to be the NFAT-target genes in mediating RTK and ..
  24. Regulation of Cell Growth by RNA Binding Proteins
    Nikolai A Timchenko; Fiscal Year: 2012
    ..Consistent with this hypothesis, levels of cyclin D1 and cyclin D3, which are activators of cdk4, are increased in cytoplasmic extracts of human liver tumors and in ..
  25. Epidermal stem cell properties in mice with altered polyamines
    Lisa M Shantz; Fiscal Year: 2010
    ..The proposed experiments use mice with expression of AZ in the skin, along with either MEK or cyclin D1 (CD1), which like ODC is a downstream target of MEK...
  26. Microvesicle Dynamics in B-Cell Chronic Lymphocytic Leukemia Tumor Microenvironme
    ASISH KUMAR GHOSH; Fiscal Year: 2013
    ..vascular endothelial growth factor (VEGF), a facilitator of leukemic B-cell survival, and sustained increases in cyclin D1 and c-myc, at least in part, by delivering Axl receptor tyrosine kinase (RTK)...
  27. Role of Cyclins in Brain Construction and Interneuron Genesis
    KRISTIN GIAMANCO; Fiscal Year: 2013
    ..development and brain construction we will compare and contrast the actions of G1-phase cyclin D2 (cD2) versus cyclin D1 (cD1), cell cycle proteins that regulate passage through mid-G1 toward S-phase...
    Andrew Arnold; Fiscal Year: 2012
    Primary hyperparathyroidism is a common human endocrinopathy, and cyclin D1 (PRAD1) oncogene overexpression contributes to the pathogenesis of up to 40% of parathyroid adenomas...
  29. Tumor Progression of Nuclear EGFR in Breast Cancer
    Mien Chie Hung; Fiscal Year: 2013
    ..We previously reported that the EGFR complex recognizes and binds to an AT-rich sequence (ATRS) of cyclin D1 transcription...
    Richard G Pestell; Fiscal Year: 2010
    The cyclin D1 gene encodes a rate-limiting component of the holoenzyme which phosphorylates and inactivates the retinoblastoma tumor suppressor gene (pRb)...
    JOANNA LOUISE GRODEN; Fiscal Year: 2010
    ..alters the transcription profile of cells through changes in the expression of genes such as c-myc and cyclin D1 that promote cell growth (He et al...
  32. The transcriptional basis of tumor promotion
    Joseph D Locker; Fiscal Year: 2013
    ..and Fosl2 mRNA after TCPOBOP treatment;we focused on transcriptional regulation of these three genes, and on Cyclin D1 as their downstream target...
  33. A study evaluating the effect of flaxseed on biomarkers of breast cancer risk
    Swati Kulkarni; Fiscal Year: 2010
    ..after six months in random periareolar fine needle aspiration (RPFNA) samples;2)alters estrogen regulated genes, cyclin D1, survivin and vascular endothelial growth factor (VEGF) in RPFNA samples;3) alters serum levels of IGF-1 and ..
  34. The RB pathway in liver cancer
    Julien Sage; Fiscal Year: 2013
    ..activity resulting from the silencing of the CDK4 inhibitor p16 or from increased expression of the CDK4 partner Cyclin D1. In addition, some proteins produced by HBV and HCV can inactivate RB family members, including by triggering ..
  35. B-RAF Regulation of the Cell Cycle in Melanoma
    Andrew E Aplin; Fiscal Year: 2013
    ..human melanoma cells elevates activation of the MEK-ERK1/2 pathway and regulates two key G1 cell cycle proteins: cyclin D1 and p27Kip1...
  36. Indolecarbinol target proteins and anti-cancer signaling in human melanoma cells
    Gary L Firestone; Fiscal Year: 2013
    ..the inactivation of NFkB transcriptional activity and attenuated expression of NFkB target genes such as cyclin D1. I3C triggers this response by inhibiting the NEDD4-1 mediated ubiquitination of PTEN, and in silico 3-D ..
  37. Regulation of smooth muscle cell function by CD44 in cardiovascular disease
    ELLEN PURE apos PURE'; Fiscal Year: 2012
    ..effects are mediated by CD44, and result from differential regulation of Rac- and ERK-dependent signaling to cyclin D1. HMW-HA binding to CD44 inhibits GTP-loading of Rac and Rac-dependent signaling to the cyclin D1 gene while LMW-..
  38. Adiponectin effects on leptin signaling in hepatocellular carcinoma
    Neeraj Kumar Saxena; Fiscal Year: 2011
    ..Most importantly, adiponectin treatment blocks leptin-induced i) activation of Stat3, ii) overexpression of cyclin D1, and iii) cell proliferation...
  39. Cyclin D1 and vitamin D signaling in oral keratinocyte pathophysiology
    Sanjay M Mallya; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The focus of this proposal is on the role of the cyclin D1 oncogene in oral cancer...
  40. Toll-like Receptor Regulation of Pancreatic Tumorigenesis
    George Miller; Fiscal Year: 2013
    ..characterized by dysregulated expression of numerous cell cycle regulators (p16, p21, p27, p53, Cyclin B1, Cyclin D1) and oncogenic genes (c-myc, Rb, and SHPTP1)...
    Jennifer D Black; Fiscal Year: 2013
    DESCRIPTION (from the applicant): Cyclin D1 is a tightly regulated cell cycle control molecule that functions as a critical sensor of extracellular growth stimulatory and inhibitory signals and a key determinant of progression through ..
  42. Beta Cell Regeneration by an Epigenetic Pathway
    Xianxin Hua; Fiscal Year: 2013
    ..Moreover, both menin and JunD bind to the promoter of the endogenous cyclin D1 gene, a crucial proliferation factor in beta cells...
  43. Fhit modulation of cell cycle progression and DNA damage response
    Kay Huebner; Fiscal Year: 2010
    ..DNA damage response andapoptosis associated proteins and that Fhit over-expression modulates expression of Cyclin D1, Hus1, Chk1 jind Akt/mTor/Survivin...
  44. Androgen Receptor Function in Prostate Cancer
    Richard G Pestell; Fiscal Year: 2013
    ..Prostate cancer progression correlates with increased activity/expression of AR, Akt1, c-jun and cyclin D1 and reduced histone acetylation...
  45. Mechanisms of Ischemic Kidney Injury and Repair
    ..We will determine the temporal characteristics of ATM/ATR activation and their downstream effectors (including cyclin D1, ELF4/MEF, CHK1, CHK2, p53 and gH2AX) and relate these findings to the differentiation status of the PTC...
  46. Activation of the cyclin D1 promoter by arsenite
    MARK L STEINBERG; Fiscal Year: 2012
    ..treatment of cultured human keratinocytes with arsenite at submicromolar concentrations induced expression of cyclin D1 and this was accompanied by a shift into the G2 compartment of the cell cycle...
  47. BRCA1, Sporadic Breast Cancer and Aging Women
    Hava Karsenty Avraham; Fiscal Year: 2010
    ..Aim 1: To investigate the role of Brca1 in the expression and distribution of beta-catenin and its targets (cyclin D1 and c-Myc) during mammary gland development in Brca1 mutant mice, in which Brca1 exon 11 is specifically deleted ..
  48. Regulation of Prostate Cancer Growth by PPARg Ligands
    ..To accomplish this aim, we will determine the importance of cyclin D1 down-regulation in TZDinduced decreases in cell proliferation...
  49. LRH-1 Antagonism: Impact on Estrogen-dependent Breast Cancer
    Marcia I Dawson; Fiscal Year: 2013
    ..cell proliferation and invasion that are related to its ability to induce the expression of other genes such as cyclin D1 and c-Myc...
  50. Impact of Cyclin D1 Isoforms in Breast Cancer
    Richard G Pestell; Fiscal Year: 2013
    ..b>Cyclin D1 is a proto-oncogene that is strongly implicated in breast cancer development and disease progression...
  51. Mouse Model of Age-Associated Monoclonal Gammopathy
    Peter Leif Bergsagel; Fiscal Year: 2013
    ..using novel transgenic mice, we will functionally study the role of activation of RAS and dysregulation of cyclin D1 in the progression of MGUS to MM...
  52. Targeted siRNA delivery to aberrantly activated leukocytes for treating colitis
    Motomu Shimaoka; Fiscal Year: 2010
    ..Building on our preliminary data, which showed that cyclin D1 (CyD1)-siRNA, a novel anti-inflammatory drug candidate, systemically delivered with the prototype I-tsNP induced ..
  53. Regulation of cell homeostasis by fbx4
    JOHN ALAN DIEHL; Fiscal Year: 2013
    ..responsive D-type cyclins and more specifically, how these pathways regulate accumulation of an active, nuclear cyclin D1-dependent kinase in normal versus cancerous cells...
  54. Defining molecular biomarkers for CDK4/6-based cancer therapy by RNA sequencing
    ..Dysregulation of the cell cycle is a hallmark of human cancer, in particular mantle cell lymphoma (MCL), wherein cyclin D1 is aberrantly expressed due to chromosomal t(11;14) translocation...
  55. Prevention of prostate cancer growth by a plant alkaloid
    Partha P Banerjee; Fiscal Year: 2013
    ..observed that mahanine restores RASSF1A expression in human and mouse prostate cancer cells and down-regulates cyclin D1 expression...
  56. Fibrosis-Protease Cross-Talk Regulating Pancreatic Cancer Invasion
    Hidayatullah G Munshi; Fiscal Year: 2013
    ..Our preliminary data also indicate that MT1-MMP increases cyclin D1 expression and enhances p38 MAPK signaling to promote growth in collagen-rich microenvironment...
  57. wnt Signaling in Liver Development and Disease
    Wolfram Goessling; Fiscal Year: 2009 using the transgenic beta-catenin fish and other transgenic fish expressing the effectors of the wnt pathway, cyclin D1 and myc...
  58. Transcriptional Regulation by the HTLV-1 Tax Protein
    Jennifer K Nyborg; Fiscal Year: 2013
    ..In addition to inducing CREB phosphorylation, Tax also binds in a stable complex with pCREB at the cyclin D1 CRE...
  59. Altered cellular bioenergetics influences NKT cell mediated responses to Lymphoma
    Tonya J Webb; Fiscal Year: 2012
    ..MCL is characterized by the chromosomal translocation and nuclear overexpression of cyclin D1. Secondary chromosomal abnormalities and dysregulation of cell cycle machinery also contribute to MCL ..
    Jennifer Black; Fiscal Year: 2009
    b>Cyclin D1 is a tightly regulated cell cycle control molecule that functions as a critical sensor of extracellular growth stimulatory and inhibitory signals and a key determinant of progression through G1 phase...
  61. Role of Wnt/Beta-Catenin Signaling in Liver Development
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..The molecular basis of these findings will be elucidated. Thus, this proposal will be a comprehensive analysis of canonical &noncanonical Wnt signaling in hepatic biology. ..
  62. Role of slug in hematopoietic stem cell regeneration
    Wen Shu Wu; Fiscal Year: 2012
    ..studies suggest that Slug is a potent negative regulator of c-kit and other cell cycle regulators (including cyclin D1, c-Myc, and Id3), while it is positively regulated by the SCF/c-Kit signaling in HSCs...
    Jeffrey Pollard; Fiscal Year: 2005
    ..Our studies in the uterine epithelium have shown that E2 induces the re-localization of cyclin D1 and Cdk-4 to the nucleus and, results in orderly activation of cyclin-E and cyclin ACdk-2 activities and hyper-..
  64. Mouse Models of ErbB-2 and Cyclin D1 in Prostate Cancer
    Christopher Albanese; Fiscal Year: 2002
    In the current studies we aim to directly determine the role of ErbB-2 and cyclin D1 in cellular proliferation and transformation in prostate cancer cells...
    Philip Hinds; Fiscal Year: 2006
    ..Examples of this include overexpression of cyclin D1 in breast tumors and loss of p16r[INK4] in melanoma and many other tumor types...
  66. Role of Protein (S14)in Normal and Neoplastic Mammary
    WILLIAM KINLAW; Fiscal Year: 2005
    ..Genes coding S14 and Cyclin D1, a mammary oncogene that is also key for normal mammary development, both reside on the l lq13 cancer amplicon...
    MARC HERSHENSON; Fiscal Year: 2002 indicating that the 21 kD GTPase Rac1 is sufficient to induce transcriptional activation of two G1 cyclins, cyclin D1 and cyclin A, in bovine tracheal myocytes...
    RICHARD ASSOIAN; Fiscal Year: 2007
    b>Cyclin D1 is an important regulator of cell cycle progression through G1 phase...
  69. Biomarkers of Progression to Esophageal Adenocarcinoma
    GIULIANA JULIE IZZO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The overall goal of this proposal is not only to confirm that cyclin D1 (CD1) G/A870 polymorphism results in a higher risk of progression from Barrett's esophagus (BE) with metaplasia to high-..
    MARC HERSHENSON; Fiscal Year: 2003
    ..In bovine tracheal myocytes, PDGF treatment and Rac1, each of which induce transcription from the cyclin D1 promoter, activate the stress-activated MAP kinases P38alpha and Jun amino-terminal kinase (JNK)-1, consistent ..