c type natriuretic peptide

Summary

Summary: A PEPTIDE of 22 amino acids, derived mainly from cells of VASCULAR ENDOTHELIUM. It is also found in the BRAIN, major endocrine glands, and other tissues. It shares structural homology with ATRIAL NATRIURETIC FACTOR. It has vasorelaxant activity thus is important in the regulation of vascular tone and blood flow. Several high molecular weight forms containing the 22 amino acids have been identified.

Top Publications

  1. pmc Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP
    Ondrej Lisy
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 52:60-8. 2008
  2. ncbi Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification
    Takashi Miyazawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 143:3604-10. 2002
  3. ncbi Human C-type natriuretic peptide. Characterization of the gene and peptide
    Y Ogawa
    Second Division, Kyoto University School of Medicine, Japan
    Hypertension 19:809-13. 1992
  4. ncbi Furin-mediated processing of Pro-C-type natriuretic peptide
    Chengliang Wu
    Department of Cardiovascular Research, Berlex Biosciences, Richmond, California 94804, USA
    J Biol Chem 278:25847-52. 2003
  5. pmc C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression
    Ramona S Scotland
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6AE, United Kingdom
    Proc Natl Acad Sci U S A 102:14452-7. 2005
  6. ncbi C-type natriuretic peptide (CNP) in rats and humans
    Y Komatsu
    Department of Medicine, Kyoto University School of Medicine, Japan
    Endocrinology 129:1104-6. 1991
  7. ncbi C-type natriuretic peptide in vascular physiology and disease
    Ramona S Scotland
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building Gower Street, London WC1E 6AE, UK
    Pharmacol Ther 105:85-93. 2005
  8. ncbi Natriuretic peptide family: new aspects
    Luis Bolanos Cea
    Severo Ochoa, sn Hospital Xeral Calde, 27004, Lugo, Spain
    Curr Med Chem Cardiovasc Hematol Agents 3:87-98. 2005
  9. ncbi Synthetic mammalian C-type natriuretic peptide forms large cation channels
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra
    FEBS Lett 445:57-62. 1999
  10. ncbi Expression of natriuretic peptides in rat Müller cells
    Li Hui Cao
    Institute of Neurobiology, Institutes of Brain Science, Fudan University, 220 Han Dan Road, Shanghai 200433, PR China
    Neurosci Lett 365:176-9. 2004

Detail Information

Publications190 found, 100 shown here

  1. pmc Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP
    Ondrej Lisy
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 52:60-8. 2008
    ..Our aim was to design, synthesize and test in vivo and in vitro a new chimeric peptide that would combine the beneficial properties of 2 distinct natriuretic peptides with a biological profile that goes beyond native peptides...
  2. ncbi Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification
    Takashi Miyazawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Endocrinology 143:3604-10. 2002
    ..This study provides in vivo and in vitro genetic evidence that cGKII plays a critical role in CNP-mediated endochondral ossification...
  3. ncbi Human C-type natriuretic peptide. Characterization of the gene and peptide
    Y Ogawa
    Second Division, Kyoto University School of Medicine, Japan
    Hypertension 19:809-13. 1992
    ....
  4. ncbi Furin-mediated processing of Pro-C-type natriuretic peptide
    Chengliang Wu
    Department of Cardiovascular Research, Berlex Biosciences, Richmond, California 94804, USA
    J Biol Chem 278:25847-52. 2003
    ..The furin-processed CNP was shown to be biologically active in a cell-based cGMP assay. These results demonstrate that furin is a critical enzyme for the processing of human pro-CNP...
  5. pmc C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression
    Ramona S Scotland
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6AE, United Kingdom
    Proc Natl Acad Sci U S A 102:14452-7. 2005
    ..These observations suggest that endothelial CNP might maintain an anti-atherogenic influence on the blood vessel wall and represent a target for therapeutic intervention in inflammatory cardiovascular disorders...
  6. ncbi C-type natriuretic peptide (CNP) in rats and humans
    Y Komatsu
    Department of Medicine, Kyoto University School of Medicine, Japan
    Endocrinology 129:1104-6. 1991
    ....
  7. ncbi C-type natriuretic peptide in vascular physiology and disease
    Ramona S Scotland
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building Gower Street, London WC1E 6AE, UK
    Pharmacol Ther 105:85-93. 2005
    ....
  8. ncbi Natriuretic peptide family: new aspects
    Luis Bolanos Cea
    Severo Ochoa, sn Hospital Xeral Calde, 27004, Lugo, Spain
    Curr Med Chem Cardiovasc Hematol Agents 3:87-98. 2005
    ..These are capable of strengthening NP and inhibiting renin-angiotensin system at the same time, as potential useful molecules in cardiovascular therapy...
  9. ncbi Synthetic mammalian C-type natriuretic peptide forms large cation channels
    J I Kourie
    Department of Chemistry, The Faculties, The Australian National University, Canberra
    FEBS Lett 445:57-62. 1999
    ....
  10. ncbi Expression of natriuretic peptides in rat Müller cells
    Li Hui Cao
    Institute of Neurobiology, Institutes of Brain Science, Fudan University, 220 Han Dan Road, Shanghai 200433, PR China
    Neurosci Lett 365:176-9. 2004
    ..These results raise a possibility that NPs, when released from Müller cells, may perform layer dependent functions...
  11. ncbi Natriuretic peptide system in the human retina
    Raquel Rollin
    Unidad de Investigacion, Departamento de Medicina Interna III, Hospital Clinico San Carlos, Madrid, Spain
    Mol Vis 10:15-22. 2004
    ..The expression pattern of the genes encoding the different NP receptor subtypes was also examined...
  12. ncbi Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway
    Akihiro Yasoda
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho Sakyo ku, Kyoto 606 8507, Japan
    Nat Med 10:80-6. 2004
    ..These results demonstrate that activation of the CNP-GC-B system in endochondral bone formation constitutes a new therapeutic strategy for human achondroplasia...
  13. ncbi C-type natriuretic peptide and guanylyl cyclase B receptor
    Stephanie Schulz
    Division of Clinical Pharmacology, Department of Medicine and Biochemistry, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Peptides 26:1024-34. 2005
    ..This review will examine the structure and function of GC-B, and summarize the physiological processes in which this receptor is thought to participate...
  14. pmc Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs
    Naohisa Tamura
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:17300-5. 2004
    ..This result was due to the failure of the female reproductive tract to develop. Thus, the guanylyl cyclase B receptor is critical for the development of both bone and female reproductive organs...
  15. ncbi Complementary antagonistic actions between C-type natriuretic peptide and the MAPK pathway through FGFR-3 in ATDC5 cells
    Ami Ozasa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho Sakyo ku, Kyoto 606 8507, Japan
    Bone 36:1056-64. 2005
    ..Our results may explain one of the molecular mechanisms of the growth stimulating action of CNP and suggest that activation of the CNP/GC-B pathway may be effective as a novel therapeutic strategy for achondroplasia...
  16. ncbi C-natriuretic peptide: an important regulator of cartilage
    Katerina Pejchalova
    Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, SSB 3, Los Angeles, CA 90048, USA
    Mol Genet Metab 92:210-5. 2007
    ..This review summarizes our current knowledge about the mechanism of CNP signaling in cartilage, areas for future investigation and its potential therapeutic uses...
  17. ncbi C-type natriuretic peptide: an important neuroendocrine regulator?
    R C Fowkes
    Department of Clinical Biochemistry, St Bartholomew s and the Royal London School of Medicine and Dentistry, West Smithfield, London, UK EC1A 7BE
    Trends Endocrinol Metab 11:333-8. 2000
    ..Here, we review this possibility, emphasizing signalling and integration with other regulatory systems in the neuroendocrine control of reproduction...
  18. pmc Dwarfism and early death in mice lacking C-type natriuretic peptide
    H Chusho
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 98:4016-21. 2001
    ..This study demonstrates that CNP acts locally as a positive regulator of endochondral ossification in vivo and suggests its pathophysiological and therapeutic implication in some forms of skeletal dysplasia...
  19. ncbi Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis
    Pavel Krejci
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Cell Sci 118:5089-100. 2005
    ..We conclude that CNP utilizes both direct and indirect ways to counteract the effects of FGF signaling in a chondrocyte environment...
  20. ncbi The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging
    Hiroyuki Kaneki
    Faculty of Pharmaceutical Sciences, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    J Cell Biochem 103:753-64. 2008
    ..From these results, we concluded that CNP acts as a positive regulator of bone formation by osteoblasts and that the signaling pathway for CNP is switched from NPR-B/cGMP/PKG to NPR-C/G(i) protein/PLC with aging...
  21. ncbi Significance of C-type natriuretic peptide (CNP) in endochondral ossification: analysis of CNP knockout mice
    Yasato Komatsu
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Japan
    J Bone Miner Metab 20:331-6. 2002
  22. ncbi Overexpression of the C-type natriuretic peptide (CNP) is associated with overgrowth and bone anomalies in an individual with balanced t(2;7) translocation
    Renata Bocciardi
    Laboratory of Molecular Genetics, G Gaslini Institute, Genova, Italy
    Hum Mutat 28:724-31. 2007
    ..Several evidences support the conclusion that the proband's abnormal phenotype is associated with C-type natriuretic peptide overexpression...
  23. ncbi Molecular physiology of natriuretic peptide signalling
    Michaela Kuhn
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Domagkstrasse 12, Munster 48149, Germany
    Basic Res Cardiol 99:76-82. 2004
    ....
  24. ncbi C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells
    Dolkun Rahmutula
    Department of Medicine and Diabetes Center, 1109 HSW, University of California at San Francisco, San Francisco, California 94143 0540, USA
    Endocrinology 146:4968-74. 2005
    ..This report provides the first documentation that CNP is capable of autoregulating the expression of its cognate receptor...
  25. ncbi Effects of natriuretic peptides on ventricular myocyte contraction and role of cyclic GMP signaling
    Qihang Zhang
    Heart and Brain Circulation Laboratory, Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, Piscataway, NJ 08854 5635, USA
    Eur J Pharmacol 510:209-15. 2005
    ..Blockade the effect of CNP by a cyclic GMP protein kinase inhibitor demonstrated that effects were mediated through the cyclic GMP signaling pathway...
  26. ncbi Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone
    - He Xl
    Departments of Microbiology and Immunology and Structural Biology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 93405 5124, USA
    Science 293:1657-62. 2001
    ..In each monomer, the opening of an interdomain cleft, which is tethered together by a linker peptide acting as a molecular spring, is likely a conserved allosteric trigger for intracellular signaling by the natriuretic receptor family...
  27. pmc Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide
    M F Goy
    Departments of Cell and Molecular Physiology, University of North Carolina, Box 7545, Chapel Hill, NC 27599, USA
    Biochem J 358:379-87. 2001
    ..This residual response to BNP cannot be accounted for by natriuretic peptide receptor B, or any other known mammalian rGC, suggesting the presence of a novel receptor in these tissues that prefers BNP over ANP...
  28. ncbi Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway
    N Herring
    University Laboratory of Physiology, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 281:H2318-27. 2001
    ..Like NO, BNP and CNP facilitate vagal neurotransmission and bradycardia. This may occur via a cGMP-PDE3-dependent pathway increasing cAMP-PKA-dependent phosphorylation of presynaptic N-type calcium channels...
  29. ncbi Activity and expression of soluble and particulate guanylate cyclases in myometrium from nonpregnant and pregnant women: down-regulation of soluble guanylate cyclase at term
    J F Telfer
    Department of Obstetrics and Gynecology, University of Glasgow, Glasgow, Scotland G31 2ER
    J Clin Endocrinol Metab 86:5934-43. 2001
    ..A reduction in cGMP availability may contribute to the switch to contractile activity at term...
  30. ncbi Expression and control of C-type natriuretic peptide in rat vascular smooth muscle cells
    Geoffrey E Woodard
    Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 282:R156-65. 2002
    ..This provides evidence for a vascular natriuretic peptide autocrine system of physiological relevance in these cells...
  31. ncbi Functional analysis of natriuretic peptide receptors in the bladder of the toad, Bufo marinus
    Stuart K Meier
    School of Biological and Chemical Sciences, Deakin University, Geelong, Victoria, 3217, Australia
    Gen Comp Endocrinol 125:207-17. 2002
    ..This study identified a well-developed natriuretic peptide receptor system in the urinary bladder of B. marinus but the function of the receptors remains unclear...
  32. ncbi Natriuretic peptides inhibit adenylyl cyclase activity in dispersed eel gill cells
    W Callahan
    School of Biological and Chemical Sciences, Deakin University, VIC 3217, 3217, Geelong, Vic, Australia
    J Comp Physiol B 174:275-80. 2004
    ..BBXXB (B = basic, X = nonbasic residues). These data suggest that branchially-expressed NPR-C may play a physiological role additional to that of ligand clearance...
  33. ncbi Differential responses of newborn pulmonary arteries and veins to atrial and C-type natriuretic peptides
    Jean Francois Tolsa
    Neonatal Research Laboratory, Division of Neonatology, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 282:H273-80. 2002
    ..Furthermore, the differences in receptor abundance and the involvement of a cGMP-independent mechanism may contribute to the heterogeneous effects of the natriuretic peptides in PA and PV of newborn lambs...
  34. ncbi Atrial natriuretic factor and C-type natriuretic peptide induce retraction of human thyrocytes in monolayer culture via guanylyl cyclase receptors
    D F Sellitti
    Department of Medicine, Divisions of Endocrinology and Nephrology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road A3060, Bethesda, MD 20814 4799, USA
    J Endocrinol 173:169-76. 2002
    ..These results suggest that the actions of NPR-A and NPR-B, functional receptors in the human thyroid cell, may in part be mediated by cGMP-induced alterations in the cytoskeleton...
  35. ncbi Quercetin, a phytoestrogen and dietary flavonoid, activates different membrane-bound guanylate cyclase isoforms in LLC-PK1 and PC12 cells
    Zi Jiang Chen
    Department of Medicine, Reproductive Research Center, Shandong Provincial Hospital, Shandong University, Jinan, P R China
    J Pharm Pharmacol 55:353-8. 2003
    ..These results indicate that quercetin activates the GC-B isoform in PC12 cells, but activates an unknown membrane-bound guanylate cyclase isoform in LLC-PK1 cells...
  36. ncbi Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts
    Takeshi Horio
    Department of Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Endocrinology 144:2279-84. 2003
    ..CNP produced by cardiac fibroblasts may play a role as an autocrine regulator against excessive cardiac fibrosis...
  37. ncbi Effect of ischemia on soluble and particulate guanylyl cyclase-mediated cGMP synthesis in cardiomyocytes
    Luis Agulló
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, 08035 Barcelona, Spain
    Am J Physiol Heart Circ Physiol 284:H2170-6. 2003
    ..These data support the relevance of intracellular pH as a modulator of cGMP and suggest that, in ischemic cardiomyocytes, synthesis of cGMP would be mainly nitric oxide dependent...
  38. pmc Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling
    Melanie Madhani
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6AE
    Br J Pharmacol 139:1289-96. 2003
    ....
  39. ncbi Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: importance of cyclic GMP
    Anke C Rosenkranz
    Howard Florey Institute, C The University of Melbourne, Parkville, VIC 3010, Australia
    Cardiovasc Res 57:515-22. 2003
    ..However, whether this effect is retained in the adult phenotype or if other members of the natriuretic peptide family exhibit similar antihypertrophic properties, has not been elucidated...
  40. ncbi Lysophosphatidic acid inhibits C-type natriuretic peptide activation of guanylyl cyclase-B
    Sarah E Abbey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Endocrinology 144:240-6. 2003
    ..We hypothesize that cross-talk between the LPA and CNP signaling pathway maximizes the response of fibroblasts in the wound-healing process...
  41. ncbi Inhibitory effect of C-type natriuretic peptide on spontaneous contraction in gastric antral circular smooth muscle of rat
    Hui Shu Guo
    Research Laboratory of Digestive Physiology, College of Medicine, Yanbian University, Yanji 133000, China
    Acta Pharmacol Sin 24:1021-6. 2003
    ..To investigate the effect of natriuretic peptides on gastric motility and its possible mechanism...
  42. ncbi Vasopressin-dependent inhibition of the C-type natriuretic peptide receptor, NPR-B/GC-B, requires elevated intracellular calcium concentrations
    Sarah E Abbey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:42423-30. 2002
    ..Together, these data reveal a dominant role for intracellular calcium in the reciprocal regulation of these two important vasoactive signaling systems...
  43. ncbi Renal C-type natriuretic peptide and natriuretic peptide receptor B mRNA expression are affected by water deprivation in the Spinifex Hopping mouse
    Rachel A Heimeier
    School of Biological and Chemical Sciences, Deakin University, Geelong, VIC 3217, Australia
    Comp Biochem Physiol A Mol Integr Physiol 136:565-75. 2003
    ..This study shows that alterations in the renal CNP/NPR-B system may be an important physiological adjustment when water is scarce...
  44. ncbi Local renal and vascular natriuretic peptide system in obstructive uropathic rats
    Soo Wan Kim
    Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
    Urol Res 30:97-101. 2002
    ..Our results suggest that the local synthesis of natriuretic peptides is increased in the kidney and in the vasculature in obstructive uropathy...
  45. ncbi Postnatal changes in inhibitory effect of C-type natriuretic peptide on secretion of ANP
    Suhn Hee Kim
    Department of Physiology, Medical School, Institute for Medical Sciences, Jeonbug National University, JeonJu 561 180, Korea
    Am J Physiol Regul Integr Comp Physiol 282:R1672-9. 2002
    ..Therefore, we conclude that the inhibitory effect of CNP on atrial ANP secretion is developmentally regulated, being absent during normal cardiac development in young animals and intact in adult animals...
  46. ncbi NPR-C receptors are involved in C-type natriuretic peptide response on bile secretion
    Maria E Sabbatini
    Cátedra de Fisiopatologi a, Facultad de Farmacia y Bioqui mica, Universidad de Buenos Aires, Juni n 956, 5 piso 1113, Buenos Aires, Argentina
    Regul Pept 116:13-20. 2003
    ..The present study shows that CNP modulates bile secretion in the rat, suggesting that CNP may be part of the large family of peptides involved in the regulation of gastrointestinal physiology...
  47. ncbi Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice
    Melanie Pierkes
    Institute of Pharmacology and Toxicology, University of Munster, Domagkstrasse 12, D 48129 Munster, Germany
    Cardiovasc Res 53:852-61. 2002
    ..In the present study we evaluated the effects of ANP and CNP on cardiac function of wild-type (GC-A +/+) and GC-A-deficient (GC-A -/-) mice...
  48. ncbi Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure
    Matthias Schmitt
    Wales Heart Research Institute, Cardiff, UK
    Arterioscler Thromb Vasc Biol 24:911-7. 2004
    ....
  49. ncbi Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP
    Laura K Antos
    Dept of Biochemistry, Molecular Biology and Biophysics, Univ of Minnesota, 6 155 Jackson, 321 Church St SE, Minneapolis, MN 55455, USA
    Am J Physiol Endocrinol Metab 293:E1756-63. 2007
    ..We conclude that ATP is not required for the initial activation of NPRs but does increase activity over time by reducing the apparent K(m) for GTP...
  50. ncbi Natriuretic peptides differentially attenuate thrombin-induced barrier dysfunction in pulmonary microvascular endothelial cells
    James R Klinger
    Pulmonary Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Brown Medical School, Research Services, Providence, RI 02908, USA
    Exp Cell Res 312:401-10. 2006
    ..We conclude that ANP and BNP protect against thrombin-induced barrier dysfunction in the pulmonary microcirculation by a cGMP-independent mechanism, possibly by attenuation of RhoA activation...
  51. ncbi Characterization of C-type natriuretic peptide receptors in human mesangial cells
    J Zhao
    INSERM 64, Hopital Tenon, Paris, France
    Kidney Int 46:717-25. 1994
    ..ANPR-A, ANPR-B and ANPR-C mRNA were present in epithelial cells whereas only ANPR-B and ANPR-C mRNA were detected in mesangial cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  52. ncbi Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice
    C Christoffersen
    Department of Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Eur J Clin Invest 36:69-75. 2006
    ..The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors...
  53. ncbi ANP-mediated cGMP signaling and phosphodiesterase inhibition in the rat cervical spinal cord
    J de Vente
    European Graduate School of Neuroscience EURON, Maastricht University, Department of Psychiatry and Neuropsychology, UNS50, POB 616, 6200 MD Maastricht, The Netherlands
    J Chem Neuroanat 31:263-74. 2006
    ..PDE2, 5, and 9 are involved in regulating NP-stimulated cGMP levels in the spinal cord. NPs may have a role in regulating cerebrospinal fluid homeostasis...
  54. ncbi Cloning and expression of an ATP-regulated human retina C-type natriuretic factor receptor guanylate cyclase
    T Duda
    Unit of Regulatory and Molecular Biology, Pennsylvania College of Optometry, Philadelphia 19141
    Biochemistry 32:1391-5. 1993
    ..We now report the molecular cloning and expression of CNP-RGC from human retina and show that ATP is obligatory in CNP signaling also.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. ncbi Detection of membrane-bound guanylate cyclase activity in rat C6 glioma cells at different growth states following activation by natriuretic peptides
    G Sorci
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Brain Res 683:51-8. 1995
    ..These data suggest that GC is differentially located depending on the state of growth of glial cells, and that in differentiating glial cells GC is preferentially located in cell processes...
  56. ncbi Direct comparison of relaxation and cGMP production in human coronary by-pass grafts in response to stimulation with natriuretic peptides and a nitric oxide donor
    Angelika Hammerer-Lercher
    Division of Clinical Biochemistry, Innsbruck Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Clin Sci (Lond) 111:225-31. 2006
    ..In contrast with sin-1, ANP and BNP were not effective vasorelaxants of the SV. Net relaxation in response to natriuretic peptides correlated with cGMP net concentrations in the IMA...
  57. ncbi Structural determinants of natriuretic peptide receptor specificity and degeneracy
    Xiao lin He
    Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 94305 5124, USA
    J Mol Biol 361:698-714. 2006
    ....
  58. ncbi In vitro effects of homologous natriuretic peptides on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus
    Bradley K Fox
    Hawaii Institute of Marine Biology, University of Hawaii, P O Box 1346, Kaneohe, HI 96744, USA
    Gen Comp Endocrinol 150:270-7. 2007
    ..These results indicate a long-lasting stimulation of GH and PRL release by ANP and BNP that is mediated, at least in part, by the guanylyl cyclase-linked NP receptor...
  59. ncbi Differential regulation of membrane guanylyl cyclases in congestive heart failure: natriuretic peptide receptor (NPR)-B, Not NPR-A, is the predominant natriuretic peptide receptor in the failing heart
    Deborah M Dickey
    University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street Southeast, Minneapolis, Minnesota 55455, USA
    Endocrinology 148:3518-22. 2007
    ..Based on these findings, we suggest that drugs that target both NPRs may be more beneficial than drugs like nesiritide (Natrecor) that target NPR-A alone...
  60. ncbi Natriuretic peptides and therapeutic applications
    Candace Y W Lee
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55906, USA
    Heart Fail Rev 12:131-42. 2007
    ..In this article, the therapeutic applications of NPs in the acute heart failure syndromes are reviewed. Emerging therapeutic agents and areas for future research are discussed...
  61. ncbi Four peptide hormones' specific decrease (up to 97%) of human prostate carcinoma cells
    B A Vesely
    University of South Florida Cardiac Hormone Center and James A Haley Veterans Medical Center, Tampa, FL 33612, USA
    Eur J Clin Invest 35:700-10. 2005
    ..Whether these effects are specific and whether they have anticancer effects in prostate adenocarcinoma cells has not been determined...
  62. ncbi C-type natriuretic peptide applied to the brain enhances exocrine pancreatic secretion through a vagal pathway
    Maria E Sabbatini
    Catedra de Fisiopatologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Eur J Pharmacol 524:67-74. 2005
    ..Present findings show that centrally applied CNP enhanced pancreatic secretion through a vagal pathway and suggest that CNP response is mediated by the activation of natriuretic peptide guanylyl cyclase coupled receptors in the brain...
  63. ncbi Contractility of late pregnant rat myometrium is refractory to activation of soluble but not particulate guanylate cyclase
    E Fulep
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Am J Obstet Gynecol 185:158-62. 2001
    ..Thus spontaneous uterine contractions are under the control of both soluble and particulate guanylate cyclases; the former is dependent on gestational age but the latter is not...
  64. ncbi Dendroaspis natriuretic peptide and its functions in pig ovarian granulosa cells
    Feng Lian Piao
    Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, 2 20 Keum Am Dong San, Jeonju 560 181, South Korea
    Regul Pept 118:193-8. 2004
    ..Increases in production of cGMP in granulosa cells were observed by DNP or CNP. Therefore, these results show the existence of DNP system and the cross-talk between natriuretic peptides in pig ovarian granulosa cells...
  65. ncbi Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice
    Martin Steinmetz
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Regul Pept 119:31-7. 2004
    ..Changes at the GC-B receptor level are likely to explain the diminished responsiveness of GC-A-deficient RRA to CNP...
  66. ncbi Differential expression and synthesis of natriuretic peptides determines natriuretic peptide receptor expression in primary cultures of human proximal tubular cells
    S K Mistry
    Department of Medicine and Therapeutics, Aberdeen University Medical School, Foresterhill, UK
    J Hypertens 19:255-62. 2001
    ....
  67. ncbi Dendroaspis natriuretic peptide system and its paracrine function in rat colon
    Jong Hun Kim
    Department of General Surgery, Chonbuk National University Medical School, Jeonju 560 181, South Korea
    Regul Pept 120:93-8. 2004
    ..This study demonstrates the presence of DNP system in rat colon and its function as a local regulator of colonic motility...
  68. ncbi [The cardiac natriuretic peptides]
    S Vittorini
    Istituto di Fisiologia del CNR, Pisa
    Minerva Med 97:79-93. 2006
    ..Therefore, it can be hypothesized that the cardiac natriuretic peptide system is closely related with other regulatory systems in a biological hierarchical networks...
  69. ncbi Postnatal ontogeny of natriuretic peptide systems in the rat hypothalamus
    Marek Jankowski
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Pavillon de Bullion, 3850 Rue Saint Urbain, Montreal, Quebec H2W 1T7, Canada
    Brain Res Dev Brain Res 152:39-46. 2004
    ..In conclusion, we have shown that hypothalamic ANP undergoes a dramatic rise after birth, and progresses further until the 3rd postnatal week. ANP and CNP changes in the developing hypothalamus can influence brain maturation...
  70. ncbi C-type natriuretic peptide as a podocyte hormone and modulation of its cGMP production by glucose and mechanical stress
    Barbara Lewko
    Department of Immunopathology, Medical University of Gdansk, Gdansk, Poland
    Kidney Int 66:1001-8. 2004
    ..We investigated whether mechanical stress and high ambient glucose influence cGMP generation in podocytes stimulated with NPs. Additionally, the C-type natriuretic peptide (CNP) system has been characterized in these cells...
  71. ncbi [Growth promoting effect of natriuretic peptides on bones formed through endochondral ossification]
    Akihiro Yasoda
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
    Nihon Rinsho 62:60-4. 2004
  72. ncbi Four peptide hormones decrease the number of human breast adenocarcinoma cells
    B A Vesely
    Department of Biochemistry and Molecular Biology, University of South Florida Cardiac Hormone Center and James A Haley Veteran s Administration Medical Center, Tampa, FL, USA
    Eur J Clin Invest 35:60-9. 2005
    ....
  73. ncbi Hyperammonemia inhibits the natriuretic peptide receptor 2 (NPR-2)-mediated cyclic GMP synthesis in the astrocytic compartment of rat cerebral cortex slices
    Magdalena Zielinska
    Department of Neurotoxicology, Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warsaw, Poland
    Neurotoxicology 28:1260-3. 2007
    ..Deregulation of NPR-2 function in astrocytes by ammonia may contribute to neurophysiological symptoms of HA...
  74. ncbi The guanylyl cyclase-deficient mouse defines differential pathways of natriuretic peptide signaling
    M J Lopez
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9050, USA
    J Biol Chem 272:23064-8. 1997
    ..Thus, two natriuretic peptides (ANP, BNP) act through GC-A whereas another (CNP) acts through another receptor to regulate blood pressure...
  75. pmc Potassium channels in the peripheral microcirculation
    William F Jackson
    Department of Biological Sciences, Western Michigan University, Kalamazoo, MI 49008 5410, USA
    Microcirculation 12:113-27. 2005
    ..EC KATP channels may be activated by vasodilators as in VSM. Kv channels may provide a negative feedback mechanism to limit depolarization in some endothelial cells...
  76. ncbi Natriuretic peptides in fish physiology
    C A Loretz
    Department of Biological Sciences, Box 601300, State University of New York at Buffalo, Buffalo, NY 14260 1300, USA
    Comp Biochem Physiol A Mol Integr Physiol 125:169-87. 2000
    ....
  77. ncbi Detection of atrial natriuretic peptide receptor in the labyrinth of the mouse inner ear
    Lili Long
    Department of Otorhinolaryngology West China Hospital of Sichuan University, Chengdu, Sichuan, P R China
    Neuro Endocrinol Lett 29:577-80. 2008
    ..To examine whether the atrial natriuretic peptide receptor (NPR-A) is present in the secretory regions of the membrane labyrinth of the adult mouse inner ear...
  78. ncbi Regulation of natriuretic peptide receptors by thyrotropin in FRTL-5 rat thyroid cells: evidence for nonguanylate cyclase atrial natriuretic factor-binding sites in cells lacking the natriuretic peptide receptor C
    D F Sellitti
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    Endocrinology 140:1365-74. 1999
    ..The vast majority of ANF-binding sites in FRTL-5 cells, therefore, are not coupled to cGMP production and may represent a novel or altered form of NPR that is regulated by TSH independently of NPR-A and NPR-B...
  79. pmc Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production
    Juliano R Guerreiro
    Center for Applied Toxinology CAT CEPID, Instituto Butantan, SP 05503 900, Sao Paulo, Brazil
    J Biol Chem 284:20022-33. 2009
    ..Therefore, we propose the activation of AsS as a new mechanism for the anti-hypertensive effect of Bj-BPP-10c in SHR and AsS as a novel target for the therapy of hypertension-related diseases...
  80. ncbi Endothelium-derived nitric oxide inhibits the relaxation of the porcine coronary artery to natriuretic peptides by desensitizing big conductance calcium-activated potassium channels of vascular smooth muscle
    Chao Fan Liang
    Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Pharmacol Exp Ther 334:223-31. 2010
    ..Endothelium-derived and exogenous NO inhibit the direct relaxing effect of natriuretic peptides by desensitizing the response of the BK(Ca)s of the vascular smooth muscle to the generation of cGMP...
  81. ncbi Natriuretic peptide guanylyl cyclase receptors in the kidney of the Japanese eel, Anguilla japonica
    J M Healy
    School of Biological and Chemical Sciences, Deakin University, Australia
    Cell Tissue Res 320:311-22. 2005
    ..These results suggest that, although utilizing the same second messenger system, ANP and CNP act on different targets within the kidney and presumably elicit different effects...
  82. ncbi Enhancement of the citrulline-nitric oxide cycle in astroglioma cells by the proline-rich peptide-10c from Bothrops jararaca venom
    Eduardo Fontana de Oliveira
    Center for Applied Toxinology CAT CEPID, Instituto Butantan, SP, Brazil
    Brain Res 1363:11-9. 2010
    ..Since NO donors have been studied for the treatment of solid cancers, Bj-PRO-10c may serve as structural model for developing drugs to improve the effects of cancer therapy based on the peptide's ability to augment NO production...
  83. ncbi The natriuretic peptide system in eels: a key endocrine system for euryhalinity?
    Yoshio Takei
    Ocean Research Institute, The University of Tokyo, Nakano Ku, Tokyo 164 8639, Japan
    Am J Physiol Regul Integr Comp Physiol 282:R940-51. 2002
    ..On the basis of these data, the authors suggest that the natriuretic peptide system is a key endocrine system that allows this euryhaline fish to adapt to diverse osmotic environments, particularly in the initial phase of adaptation...
  84. ncbi Structural and biochemical identity of retinal rod outer segment membrane guanylate cyclase
    A Margulis
    Unit of Regulatory and Molecular Biology, Pennsylvania College of Optometry, Philadelphia 19141
    Biochem Biophys Res Commun 194:855-61. 1993
    ..These results suggest that ROS-GC represents a new subtype of the membrane guanylate cyclase family that is structurally and biochemically distinct from the other retinal cyclases...
  85. ncbi Natriuretic peptides in the rat olfactory system
    J Gutkowska
    Laboratory of Cardiovascular Biochemistry, Centre de Recherche Hôtel Dieu de Montréal, Quebec, Canada
    Rev Bras Biol 56:79-88. 1996
    ..Although the role of ANP in the olfactory system is not yet clear, ANP has been shown to modulate olfactory bulb mitochondrial membrane activity and to be involved in the olfactive function...
  86. ncbi Characterization of binding sites in rat for A, B and C-type natriuretic peptides
    M L Weir
    Department of Biochemistry, Queen s University, Kingston, Canada
    Regul Pept 47:291-305. 1993
    ..CNP-22 bound to only a subset of ANP receptors and was least effective in stimulating glomerular guanylate cyclase, suggesting a differential mode of action from ANP...
  87. doi C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells
    Y Rautureau
    The Royal Veterinary College, University of London, London NW1 0TU, UK
    Auton Autacoid Pharmacol 30:185-92. 2010
    ..In conclusion, these studies indicate functional signaling by natriuretic peptides in endothelial cells, supporting possible roles of these mediators in regulating endothelial cell function...
  88. ncbi A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse
    Takehito Tsuji
    Graduate School of Natural Science and Technology, Okayama University, 1 1 1, Tsushima Naka, Okayama 700 8530, Japan
    J Biol Chem 280:14288-92. 2005
    ....
  89. ncbi Natriuretic peptides in vascular physiology and pathology
    Geoffrey E Woodard
    National Institute of Allergy and Infectious Diseases, MSC 1876, Bethesda, Maryland 20892 1876, USA
    Int Rev Cell Mol Biol 268:59-93. 2008
    ..In addition, we will attempt to provide an update on important issues regarding natriuretic peptides in congestive heart failure...
  90. ncbi Sequencing and cardiac expression of natriuretic peptide receptor 2 (NPR-B) in Sus Scrofa
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 28:1390-6. 2007
    ..Therefore, NPR-B sequencing provides a new tool to investigate the role of CNP under physiological and pathological conditions in the experimental and clinical setting...
  91. ncbi Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis
    Libia Sanz
    Instituto de Biomedicina de Valencia, C S I C, Valencia, Spain
    J Proteomics 71:46-60. 2008
    ..Our data may contribute to a deeper understanding of the biology and ecology of these snakes, and may also serve as a starting point for studying structure-function correlations of individual toxins...
  92. ncbi Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide
    Kristin Pankow
    Fachbereich Biologie, Chemie, Pharmazie, Freie Universitat Berlin, Germany
    Circ Res 101:875-82. 2007
    ..Thus, the cooperative, successive action of the 2 transmembranal peptidases meprin A and NEP is crucial for rapid renal BNP inactivation. Therefore, the inhibition of meprin A could be a potent tool for increasing circulating BNP levels...
  93. pmc Gastrointestinal tract disorder in natriuretic peptide receptor B gene mutant mice
    Chizuru Sogawa
    Department of Animal Genetics, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    Am J Pathol 177:822-8. 2010
    ..Therefore, the GIT phenotype of slw/slw mice is because of a CNP/NPR-B-signaling defect caused by an Npr2 mutation. These results facilitate better understanding of the role of CNP/NPR-B signaling in GIT motility...
  94. ncbi Rat insulin-degrading enzyme: cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry
    D Muller
    Institut fur Zellbiochemie und klinische Neurobiologie, UKE, Universitat Hamburg, FRG
    Biochemistry 31:11138-43. 1992
    ..On the basis of its structural and enzymatic properties, IDE exhibits striking similarity to a number of recently-described endopeptidases...
  95. ncbi Natriuretic peptide receptor-C signaling and regulation
    Madhu B Anand-Srivastava
    Department of Physiology and Groupe de Recherché, Sur le Système Nerveux Autonome GRSNA, Faculty of Medicine, University of Montreal, C P 6128, Succ Centre Ville, Montreal, Que, Canada H3C 3J7
    Peptides 26:1044-59. 2005
    ..In this review article, NPR-C receptor coupling to different signaling pathways and their regulation will be discussed...
  96. ncbi Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1
    Dolkun Rahmutula
    Diabetes Center and Department of Medicine, University of California at San Francisco, USA
    Hypertension 44:283-8. 2004
    ....
  97. ncbi Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide
    S Suga
    Department of Medicine, Kyoto University School of Medicine, Japan
    Endocrinology 130:229-39. 1992
    ..These findings on the receptor selectivity of the natriuretic peptide family provide a new insight into the understanding of the physiological and clinical implications of the natriuretic peptide system...
  98. doi Molecular approaches to examine the phosphorylation state of the C type natriuretic peptide receptor
    Abdel A Alli
    Research Service, James A Haley Veterans Hospital, Tampa, Florida 33612, USA
    J Cell Biochem 110:985-94. 2010
    The intracellular domain of the C type natriuretic peptide receptor (NPRC) contains one threonine and several serine residues where phosphorylation is thought to occur...
  99. ncbi Induction of L-arginine transport is inhibited by atrial natriuretic peptide: a peptide hormone as a novel regulator of inducible nitric-oxide synthase substrate availability
    A K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Mol Pharmacol 60:421-6. 2001
    ..Recently, we could show that the cardiovascular hormone atrial natriuretic peptide (ANP) inhibits the induction of iNOS in LPS-stimulated macrophages via its guanylate cyclase-coupled A-receptor...
  100. ncbi The C type natriuretic peptide receptor tethers AHNAK1 at the plasma membrane to potentiate arachidonic acid-induced calcium mobilization
    Abdel A Alli
    Research Service, James A Haley Veterans Hospital, Tampa, Florida 33612, USA
    Am J Physiol Cell Physiol 297:C1157-67. 2009
    ..We address the role of intracellular calcium in the various cell types that AHNAK1 and NPR-C were found to associate...
  101. doi Transforming growth factor-beta1 regulation of C-type natriuretic peptide expression in human vascular smooth muscle cells: dependence on TSC22D1
    Maria C Mendonca
    Department of Medicine, Divisions of Endocrinology and Nephrology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814 4799, USA
    Am J Physiol Heart Circ Physiol 299:H2018-27. 2010
    ..These results support a postulated role of TSC22D1 as an enhancer of CNP transcription and suggest that TGF-β-induced upregulation of CNP expression in SMC may be mediated in part by increased transcription of TSC22D1...

Research Grants83

  1. C-type natriuretic peptide signaling pathway disruption leading to growth arrest
    Hulya Bukulmez; Fiscal Year: 2007
    ....
  2. Mayo Heart Failure Regional Clinical Center
    MARGARET REDFIELD; Fiscal Year: 2007
    ..Specific Aim 4. Establish a Clinical HF Research Skills Development Core The objective is to train future investigators in clinical HF research facilitating their ability to attain independent status. (End of Abstract) ..
  3. Prevention of Diabetic Neuropathy with ACE Inhibitors
    Mark Yorek; Fiscal Year: 2009
    ..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of angiotensin converting enzyme and/or vasopeptidase inhibitor treatment in human diabetic neuropathy. ..
  4. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2010
    ..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of angiotensin converting enzyme and/or vasopeptidase inhibitor treatment in human diabetic neuropathy. ..
  5. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2001
    ..They are likely to increase understanding of the roles of various natriuretic peptides and natriuretic peptide receptors in IOP homeostasis. ..
  6. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel Dries; Fiscal Year: 2009
    ....
  7. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2000
    ..They are likely to increase understanding of the roles of various natriuretic peptides and natriuretic peptide receptors in IOP homeostasis. ..
  8. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel Dries; Fiscal Year: 2007
    ....
  9. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 1999
    ..They are likely to increase understanding of the roles of various natriuretic peptides and natriuretic peptide receptors in IOP homeostasis. ..
  10. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel L Dries; Fiscal Year: 2010
    ....
  11. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel Dries; Fiscal Year: 2009
    ....
  12. Identifiction of the natriuretic peptide receptor kinase
    LINCOLN POTTER; Fiscal Year: 2009
    ..The goal of this grant is to identify this critical molecule so that it can be targeted by novel drugs designed to treat cardiovascular and skeletal diseases. ..
  13. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2002
    ..dependent regulation of natriuretic peptide receptors and to use this knowledge as a stepping stone towards the development of effective therapeutic agents for the treatment of cardiovascular diseases. ..
  14. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2004
    ..dependent regulation of natriuretic peptide receptors and to use this knowledge as a stepping stone towards the development of effective therapeutic agents for the treatment of cardiovascular diseases. ..
  15. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2005
    ..dependent regulation of natriuretic peptide receptors and to use this knowledge as a stepping stone towards the development of effective therapeutic agents for the treatment of cardiovascular diseases. ..
  16. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2003
    ..dependent regulation of natriuretic peptide receptors and to use this knowledge as a stepping stone towards the development of effective therapeutic agents for the treatment of cardiovascular diseases. ..
  17. Prevention of Diabetic Neuropathy with ACE Inhibitors
    Mark Yorek; Fiscal Year: 2007
    ..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of ACE inhibitor treatment in human DN. ..
  18. Hamster: a unique model for studying implantation
    BIBHASH CHANDRA PARIA; Fiscal Year: 2010
    ....
  19. Mechanism of activation of natriuretic peptide receptors
    Focco van den Akker; Fiscal Year: 2005
    ..These proposed studies on natriuretic peptide receptors will increase our understanding of mechanisms of activation and function, and could enhance the development of new renal, cardiovascular, or skeletal growth stimulatory drugs. ..
  20. Mechanism of activation of natriuretic peptide receptors
    Focco van den Akker; Fiscal Year: 2006
    ..These proposed studies on natriuretic peptide receptors will increase our understanding of mechanisms of activation and function, and could enhance the development of new renal, cardiovascular, or skeletal growth stimulatory drugs. ..
  21. Mechanism of activation of natriuretic peptide receptors
    Focco van den Akker; Fiscal Year: 2007
    ..These proposed studies on natriuretic peptide receptors will increase our understanding of mechanisms of activation and function, and could enhance the development of new renal, cardiovascular, or skeletal growth stimulatory drugs. ..
  22. REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLS
    David Gardner; Fiscal Year: 2004
    ....
  23. REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLS
    David Gardner; Fiscal Year: 2005
    ....
  24. REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLS
    David Gardner; Fiscal Year: 2002
    ....
  25. REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLS
    David Gardner; Fiscal Year: 2003
    ....
  26. Hamster: a unique model for studying implantation
    BIBHASH CHANDRA PARIA; Fiscal Year: 2010
    ..abstract_text> ..
  27. C-type natriuretic peptide signaling pathway disruption leading to growth arrest
    Hulya Bukulmez; Fiscal Year: 2009
    ....
  28. C-type natriuretic peptide signaling pathway disruption leading to growth arrest
    Hulya Bukulmez; Fiscal Year: 2010
    ....
  29. PARACRINE REGULATION OF URINE PRODUCTION IN SLEEP APNEA
    Mary Umlauf; Fiscal Year: 1999
    ..Future studies will employ these methods and findings to test and validate a new method to differentially diagnose nocturia and/or obstructive sleep apnea by using a urine specimen. ..
  30. Phosphodiesterase 3 and Atherosclerosis
    Bradford Berk; Fiscal Year: 2007
    ..Aim 3: Determine the effect of VSMC overexpression of a PDE3 isoform on atherosclerosis using genetically modified mice. ..
  31. Phosphodiesterase 3 and Atherosclerosis
    Bradford Berk; Fiscal Year: 2006
    ..Aim 3: Determine the effect of VSMC overexpression of a PDE3 isoform on atherosclerosis using genetically modified mice. ..
  32. Phosphodiesterase 3 and Atherosclerosis
    Bradford Berk; Fiscal Year: 2005
    ..Aim 3: Determine the effect of VSMC overexpression of a PDE3 isoform on atherosclerosis using genetically modified mice. ..
  33. Guanylyl cyclase receptors: Targets for medical intervention
    Joseph Albanesi; Fiscal Year: 2007
    ..Thus, the proposed research impacts on some of our most important medical issues, including wound repair, atherosclerosis, restenosis following angioplasty, and a host of diseases associated with obesity. ..
  34. Guanylyl cyclase receptors: Targets for medical intervention
    Joseph P Albanesi; Fiscal Year: 2010
    ..Thus, the proposed research impacts on some of our most important medical issues, including wound repair, atherosclerosis, restenosis following angioplasty, and a host of diseases associated with obesity. ..
  35. Guanylyl cyclase receptors: Targets for medical intervention
    Joseph Albanesi; Fiscal Year: 2007
    ..Thus, the proposed research impacts on some of our most important medical issues, including wound repair, atherosclerosis, restenosis following angioplasty, and a host of diseases associated with obesity. ..
  36. Guanylyl cyclase receptors: Targets for medical intervention
    Joseph P Albanesi; Fiscal Year: 2010
    ..Thus, the proposed research impacts on some of our most important medical issues, including wound repair, atherosclerosis, restenosis following angioplasty, and a host of diseases associated with obesity. ..
  37. Guanylyl cyclase receptors: Targets for medical intervention
    Joseph Albanesi; Fiscal Year: 2009
    ..Thus, the proposed research impacts on some of our most important medical issues, including wound repair, atherosclerosis, restenosis following angioplasty, and a host of diseases associated with obesity. ..
  38. C-type natriuretic peptide signaling pathway disruption leading to growth arrest
    Hulya Bukulmez; Fiscal Year: 2008
    ....
  39. REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTES
    Robert Olney; Fiscal Year: 2000
    ..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..
  40. REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTES
    Robert Olney; Fiscal Year: 2001
    ..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..
  41. REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTES
    Robert Olney; Fiscal Year: 2002
    ..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..
  42. REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTES
    Robert Olney; Fiscal Year: 1999
    ..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..
  43. BRIDGES TO THE BACCALAUREATE
    George Trachte; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  44. Postdoctoral Training Program in Duluth, Minnesota
    George Trachte; Fiscal Year: 2008
    ..The research training will occur at the University of Minnesota, either on the Duluth or Twin Cities campus. The teaching portion of the training will occur at Lake Superior College or Fond du Lac Tribal and Community College. ..
  45. Postdoctoral Training Program in Duluth, Minnesota
    George Trachte; Fiscal Year: 2007
    ..The research training will occur at the University of Minnesota, either on the Duluth or Twin Cities campus. The teaching portion of the training will occur at Lake Superior College or Fond du Lac Tribal and Community College. ..
  46. Role of Natriuretic Peptides in the Cochlea
    George Trachte; Fiscal Year: 2004
    ..abstract_text> ..
  47. Regulation of H/K-ATPase in Kidney and Colon
    BRUCE KONE; Fiscal Year: 2009
    ..abstract_text> ..
  48. Function and Renal Regulation X/K -ATPase Isoforms
    BRUCE KONE; Fiscal Year: 2002
    ..abstract_text> ..
  49. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2001
    ....
  50. DISCOVERY & FUNCTION OF FERTILIZATION-SPECIFIC MOLECULES
    David Garbers; Fiscal Year: 2001
    ..It is used as an example of our line of inquiry following the discovery of a sperm-specific membrane protein which function can be predicted based on database searches. ..
  51. INTRARENAL REGULATION OF SODIUM EXCRETION
    John Burnett; Fiscal Year: 2002
    ..Aim 4: Establish that dietary sodium excess accelerates the development of cardiac remodeling and overt CHF in part via up-regulation of NEP. ..
  52. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2001
    ..abstract_text> ..
  53. Ocular Hydrodynamics: Modulation by Opioids
    David Potter; Fiscal Year: 2003
    ....
  54. OCULAR HYDRODYNAMICS--MODULATION BY OPIOIDS
    David Potter; Fiscal Year: 2001
    ....
  55. MOLECULAR BIOLOGY OF DIABETIC CATARACT FORMATION
    PATRICK CAMMARATA; Fiscal Year: 2002
    ..This study proposes to test the potential usefulness of enhancing myo-inositol efflux through chloride channels as a means for drug therapy to relieve intrafiber osmotic stress. ..
  56. DISCOVERY & FUNCTION OF FERTILIZATION-SPECIFIC MOLECULES
    David Garbers; Fiscal Year: 2004
    ..It is used as an example of our line of inquiry following the discovery of a sperm-specific membrane protein which function can be predicted based on database searches. ..
  57. Intestinal Peptides Involved in Volume Homeostasis
    MICHAEL GOY; Fiscal Year: 2008
    ..Experiments described in our application will test and extend this hypothesis, and may suggest uses for proUGn in the diagnosis or treatment of diseases in which salt and/or fluid homeostasis is deranged. ..
  58. DISCOVERY & FUNCTION OF FERTILIZATION-SPECIFIC MOLECULES
    David Garbers; Fiscal Year: 2005
    ..Based on these studies, linkage maps will begin to connect pathways from the sNHE, or other candidate gene products, to sperm behavioral responses such as motility activation or induction of the acrosome reaction. ..
  59. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM
    John Burnett; Fiscal Year: 2004
    ..In summary, the new IIRF will strategically position Mayo's research effort in the new millennium, enabling NIH-level imaging research across multiple imaging modalities in one facility. ..
  60. REGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN KIDNEY
    BRUCE KONE; Fiscal Year: 2000
    ....
  61. INTRARENAL REGULATION OF SODIUM EXCRETION
    John Burnett; Fiscal Year: 1990
    ....
  62. Regulation of ENaC Transcription
    BRUCE KONE; Fiscal Year: 2009
    ..The proposed studies will also define new modes of function for SGK1, Dot1, and AF9a that may be more broadly applicable to other target proteins and to gene regulation in general. ..
  63. OCULAR HYDRODYNAMICS--MODULATION BY OPIOIDS
    David Potter; Fiscal Year: 1999
    ....
  64. OCULAR NATRIURETIC PEPTIDE ACTIVITY: MODULATION BY DRUGS
    David Potter; Fiscal Year: 2001
    ..abstract_text> ..
  65. DISCOVERY & FUNCTION OF FERTILIZATION-SPECIFIC MOLECULES
    David Garbers; Fiscal Year: 2003
    ..It is used as an example of our line of inquiry following the discovery of a sperm-specific membrane protein which function can be predicted based on database searches. ..
  66. Postdoctoral Training in Renal Diseases and Hypertension
    BRUCE KONE; Fiscal Year: 2006
    ..It is the goal of the Program that its graduates will contribute to a new generation of academic nephrologists and renal investigators equipped to address the challenging problems in renal diseases and hypertension ..
  67. Cardiovascular Peptides and Myocardial Infarction
    John Burnett; Fiscal Year: 2009
    ..For the public, this research may enhance long-term survival after a heart attack. The use of a hormone made in the heart and given at the time of heart attack may help the heart protect and repair itself. ..
  68. Cardiovascular Peptides and Myocardial Infarction
    John Burnett; Fiscal Year: 2008
    ..For the public, this research may enhance long-term survival after a heart attack. The use of a hormone made in the heart and given at the time of heart attack may help the heart protect and repair itself. ..
  69. Regulation of H/K-ATPase in Kidney and Colon
    BRUCE KONE; Fiscal Year: 2005
    ..abstract_text> ..
  70. Regulation of ENaC Transcription
    BRUCE KONE; Fiscal Year: 2007
    ..The proposed studies will also define new modes of function for SGK1, Dot1, and AF9a that may be more broadly applicable to other target proteins and to gene regulation in general. ..
  71. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2004
    ..abstract_text> ..
  72. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2008
    ....
  73. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2003
    ....
  74. Function and Renal Regulation X/K -ATPase Isoforms
    BRUCE KONE; Fiscal Year: 2001
    ..abstract_text> ..
  75. INTRARENAL REGULATION OF SODIUM EXCRETION
    John Burnett; Fiscal Year: 1993
    ..Aim V: To determine the contrasting actions of chronic diuretic therapy and AII receptor antagonism upon the RAS and renal biological responsiveness to ANF in evolving CHF...
  76. Regulation of H/K-ATPase in Kidney and Colon
    BRUCE KONE; Fiscal Year: 2006
    ..abstract_text> ..
  77. Biology and Therapeutics of Cardiovascular Peptides
    John Burnett; Fiscal Year: 2007
    ..In Project 4, importantly extends our laboratory-based research to the understanding of the physiology and therapeutic potential of the NPs to the treatment of human disease, focusing on BNP therapy. ..
  78. Cardiac Peptides in Cardiorenal Protection
    John Burnett; Fiscal Year: 2009
    ..Aim 4: To determine the biological actions and binding properties of altered forms of circulating BNP in human HF in vitro and in vivo. ..
  79. Intestinal Peptides Involved in Volume Homeostasis
    MICHAEL GOY; Fiscal Year: 2006
    ..Experiments described in our application will test and extend this hypothesis, and may suggest uses for proUGn in the diagnosis or treatment of diseases in which salt and/or fluid homeostasis is deranged. ..