brain natriuretic peptide

Summary

Summary: A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.

Top Publications

  1. pmc Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression
    Koichiro Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 30:4134-48. 2010
  2. ncbi Brain natriuretic peptide is a prognostic parameter in chronic lung disease
    Hanno H Leuchte
    Division of Pulmonary Diseases, Department of Internal Medicine I, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
    Am J Respir Crit Care Med 173:744-50. 2006
  3. ncbi Effect of competitive marathon cycling on plasma N-terminal pro-brain natriuretic peptide and cardiac troponin T in healthy recreational cyclists
    Guenther Neumayr
    Institute of Sports Medicine and Cardiovascular Medicine, University Clinics of Innsbruck, Innsbruck, Austria
    Am J Cardiol 96:732-5. 2005
  4. ncbi Natriuretic peptides
    Lori B Daniels
    Division of Cardiology, University of California at San Diego, and Veteran s Affairs San Diego Healthcare System, San Diego, California 92037 1300, USA
    J Am Coll Cardiol 50:2357-68. 2007
  5. ncbi Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise
    Jurgen Scharhag
    Institute of Sports and Preventive Medicine, University of Saarland, Saarbrücken Homburg, Germany
    Am Heart J 150:1128-34. 2005
  6. pmc The influence of age, sex and other variables on the plasma level of N-terminal pro brain natriuretic peptide in a large sample of the general population
    I Raymond
    Department of Cardiology and Endocrinology, Copenhagen University Hospital Frederiksberg, Frederiksberg, Denmark
    Heart 89:745-51. 2003
  7. ncbi Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea
    Christian Mueller
    Department of Internal Medicine, Medical Division A, University of Basel, University Hospital, Basel, Switzerland
    N Engl J Med 350:647-54. 2004
  8. ncbi Serum N-terminal brain natriuretic peptide as a prognostic parameter in patients with pulmonary hypertension
    Anna Fijalkowska
    Department of Chest Medicine, National Research Institute of Tuberculosis and Lung Diseases, Ul Plocka 26, 01 138 Warsaw, Poland
    Chest 129:1313-21. 2006
  9. ncbi Troponin-T and brain natriuretic peptide as predictors for adriamycin-induced cardiomyopathy in rats
    Eikan Koh
    Department of Pediatrics, Kanazawa Medical University, Uchinada, Japan
    Circ J 68:163-7. 2004
  10. ncbi Plasma brain natriuretic peptide-guided therapy to improve outcome in heart failure: the STARS-BNP Multicenter Study
    Patrick Jourdain
    Rene Descartes University, Paris, France
    J Am Coll Cardiol 49:1733-9. 2007

Detail Information

Publications348 found, 100 shown here

  1. pmc Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression
    Koichiro Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 30:4134-48. 2010
    ..Expression of brain natriuretic peptide (BNP) and other SRF-dependent fetal cardiac genes in response to acute mechanical stress was blunted in ..
  2. ncbi Brain natriuretic peptide is a prognostic parameter in chronic lung disease
    Hanno H Leuchte
    Division of Pulmonary Diseases, Department of Internal Medicine I, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
    Am J Respir Crit Care Med 173:744-50. 2006
    ..The brain natriuretic peptide (BNP) has been suggested as a noninvasive marker for the presence and severity of pulmonary hypertension.
  3. ncbi Effect of competitive marathon cycling on plasma N-terminal pro-brain natriuretic peptide and cardiac troponin T in healthy recreational cyclists
    Guenther Neumayr
    Institute of Sports Medicine and Cardiovascular Medicine, University Clinics of Innsbruck, Innsbruck, Austria
    Am J Cardiol 96:732-5. 2005
    For a further depiction of exercise-induced cardiac dysfunction, N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and cardiac troponin T (cTnT) were measured in recreational cyclists (n = 29) during the Otztal Radmarathon 2004...
  4. ncbi Natriuretic peptides
    Lori B Daniels
    Division of Cardiology, University of California at San Diego, and Veteran s Affairs San Diego Healthcare System, San Diego, California 92037 1300, USA
    J Am Coll Cardiol 50:2357-68. 2007
    ..Knowing a patient's NP levels might thus assist with hemodynamic assessment and subsequent treatment titration. Monitoring NP levels in the outpatient setting might also improve patient care and outcomes...
  5. ncbi Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise
    Jurgen Scharhag
    Institute of Sports and Preventive Medicine, University of Saarland, Saarbrücken Homburg, Germany
    Am Heart J 150:1128-34. 2005
    Although elevated resting brain natriuretic peptide (BNP) concentrations reflect heart disease, the meaning of exercise-induced increases is poorly understood and has been examined in small groups only...
  6. pmc The influence of age, sex and other variables on the plasma level of N-terminal pro brain natriuretic peptide in a large sample of the general population
    I Raymond
    Department of Cardiology and Endocrinology, Copenhagen University Hospital Frederiksberg, Frederiksberg, Denmark
    Heart 89:745-51. 2003
    To identify potentially confounding variables for the interpretation of plasma N-terminal pro brain natriuretic peptide (NT-proBNP).
  7. ncbi Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea
    Christian Mueller
    Department of Internal Medicine, Medical Division A, University of Basel, University Hospital, Basel, Switzerland
    N Engl J Med 350:647-54. 2004
    ..B-type natriuretic peptide levels are higher in patients with congestive heart failure than in patients with dyspnea from other causes...
  8. ncbi Serum N-terminal brain natriuretic peptide as a prognostic parameter in patients with pulmonary hypertension
    Anna Fijalkowska
    Department of Chest Medicine, National Research Institute of Tuberculosis and Lung Diseases, Ul Plocka 26, 01 138 Warsaw, Poland
    Chest 129:1313-21. 2006
    ..We prospectively assessed the correlation of N-terminal brain natriuretic peptide (NT-proBNP) with echocardiographic and hemodynamic indexes of RV function as well as with baseline ..
  9. ncbi Troponin-T and brain natriuretic peptide as predictors for adriamycin-induced cardiomyopathy in rats
    Eikan Koh
    Department of Pediatrics, Kanazawa Medical University, Uchinada, Japan
    Circ J 68:163-7. 2004
    ..This study prospectively investigated whether atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and cardiac troponin T (TnT) are predictors for ADR-induced cardiotoxicity, and examined the ..
  10. ncbi Plasma brain natriuretic peptide-guided therapy to improve outcome in heart failure: the STARS-BNP Multicenter Study
    Patrick Jourdain
    Rene Descartes University, Paris, France
    J Am Coll Cardiol 49:1733-9. 2007
    The aim of this multicenter study was to evaluate the prognostic impact of a therapeutic strategy using plasma brain natriuretic peptide (BNP) levels.
  11. ncbi Acute changes in endocrine and fluid balance markers during high-intensity, steady-state, and prolonged endurance running: unexpected increases in oxytocin and brain natriuretic peptide during exercise
    Tamara Hew-Butler
    University of Cape Town, Cape Town, 7725 South Africa
    Eur J Endocrinol 159:729-37. 2008
    ..at rest, the potential contributions of other related endocrine factors, such as oxytocin (OT) and brain natriuretic peptide (BNP), have not been well described during exercise...
  12. doi Relation of plasma brain natriuretic peptide levels on admission for ST-elevation myocardial infarction to left ventricular end-diastolic volume six months later measured by both echocardiography and cardiac magnetic resonance
    Ana García-Alvarez
    Thorax Clinic Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Cardiol 104:878-82. 2009
    The main objective of this study was to investigate the relation between brain natriuretic peptide (BNP) levels within the first 96 hours after ST-segment elevation acute myocardial infarction (STEMI) and the development of left ..
  13. ncbi Brain natriuretic peptide and N-terminal proBNP in chronic haemodialysis patients
    Jaroslav Racek
    Institute of Clinical Biochemistry and Haematology, Department of Clinical Biochemistry and Haematology, Charles University Hospital, Pilsen, Czech Republic
    Nephron Clin Pract 103:c162-72. 2006
    b>Brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are released into circulation as a result of congestive heart failure (HF)...
  14. ncbi Direct comparison of B-type natriuretic peptide (BNP) and amino-terminal proBNP in a large population of patients with chronic and symptomatic heart failure: the Valsartan Heart Failure (Val-HeFT) data
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Clin Chem 52:1528-38. 2006
    ..This work aimed to provide a direct comparison of the prognostic value of BNP and NT-proBNP in patients with chronic and stable HF...
  15. doi Prognostic value of changes in N-terminal pro-brain natriuretic peptide in Val-HeFT (Valsartan Heart Failure Trial)
    Serge Masson
    Department of Cardiovascular Reearch, Istituto Mario Negri, Milan, Italy
    J Am Coll Cardiol 52:997-1003. 2008
    This study sought to evaluate the association between changes over time of N-terminal pro-brain natriuretic peptide (NT-proBNP) expressed in different ways and outcome in patients with stable and chronic heart failure (HF).
  16. ncbi Comparison of brain natriuretic peptide (BNP) and amino-terminal ProBNP for early diagnosis of heart failure
    Michele Emdin
    CNR Institute of Clinical Physiology, Cardiovascular Medicine Department and Cardiovascular Endocrinology Laboratory, Pisa, Italy
    Clin Chem 53:1289-97. 2007
    We compared the diagnostic accuracy of brain natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) for diagnosis of preclinical and mild heart failure (HF).
  17. doi Plasma concentration of amino-terminal pro-brain natriuretic peptide in chronic heart failure: prediction of cardiovascular events and interaction with the effects of rosuvastatin: a report from CORONA (Controlled Rosuvastatin Multinational Trial in Heart
    John G F Cleland
    Department of Cardiology, University of Hull, Kingston upon Hull, United Kingdom
    J Am Coll Cardiol 54:1850-9. 2009
    We investigated whether plasma amino-terminal pro-brain natriuretic peptide (NT-proBNP), a marker of cardiac dysfunction and prognosis measured in CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure), could be used to ..
  18. ncbi Uncovering heart failure in patients with a history of pulmonary disease: rationale for the early use of B-type natriuretic peptide in the emergency department
    Peter A McCullough
    William Beaumont Hospital, Royal Oak, MI 48073, USA
    Acad Emerg Med 10:198-204. 2003
    ..Heart failure, asthma, and chronic obstructive pulmonary disease (COPD) are syndromes where dyspnea and wheezing are overlapping signs, and hence, these syndromes are often difficult to differentiate...
  19. ncbi Effect of compensated renal dysfunction on approved heart failure markers: direct comparison of brain natriuretic peptide (BNP) and N-terminal pro-BNP
    Andreas Luchner
    Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Germany
    Hypertension 46:118-23. 2005
    b>Brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are markers of heart failure...
  20. ncbi Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study
    Saif Anwaruddin
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 47:91-7. 2006
    The relationship between renal insufficiency and amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels remains unclear...
  21. ncbi Brain natriuretic peptide-32: N-terminal six amino acid extended form of brain natriuretic peptide identified in porcine brain
    T Sudoh
    Department of Biochemistry, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 155:726-32. 1988
    b>Brain natriuretic peptide (BNP) is a newly identified peptide of 26 residues, which has a remarkable homology to but is distinct from atrial natriuretic peptide...
  22. pmc Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
    Martin Magnusson
    Department of Cardiology, Malmo University Hospital, Lund University, Lund, Sweden
    Cardiovasc Diabetol 9:2. 2010
    ....
  23. ncbi Serum N-terminal pro-brain natriuretic peptide is a sensitive marker of myocardial dysfunction in AL amyloidosis
    Giovanni Palladini
    Department of Internal Medicine, University Hospital IRCCS Policlinico San Matteo University of Pavia, Pavia, Italy
    Circulation 107:2440-5. 2003
    b>Brain natriuretic peptide (BNP) is a marker of ventricular dysfunction and can be used to assess prognosis in heart failure and after myocardial infarction...
  24. ncbi Impact of body mass and body composition on circulating levels of natriuretic peptides: results from the Dallas Heart Study
    Sandeep R Das
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circulation 112:2163-8. 2005
    ....
  25. ncbi Biomarkers in acute cardiac disease: the present and the future
    Allan S Jaffe
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic and Medical School, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 48:1-11. 2006
    ..Finally, it reflects on some of the large number of markers that are still in development...
  26. ncbi Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure
    Brian P Shapiro
    Department of Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:481-6. 2003
    Plasma concentration of brain natriuretic peptide (BNP), as measured by the Triage BNP Test, is approved by the Food and Drug Administration to aid in the diagnosis of heart failure. This diagnostic test is available in many institutions...
  27. ncbi Urine albumin/creatinine ratio, high sensitivity C-reactive protein and N-terminal pro brain natriuretic peptide--three new cardiovascular risk markers--do they improve risk prediction and influence treatment?
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark
    Curr Vasc Pharmacol 8:134-9. 2010
    ..prognostic value of 3 relatively new, but established cardiovascular risk markers: N-terminal pro brain natriuretic peptide (Nt-proBNP), related to hemodynamic cardiovascular risk factors, high sensitivity C-reactive protein (..
  28. ncbi The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study
    James L Januzzi
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Cardiol 95:948-54. 2005
    The utility of aminoterminal pro-brain natriuretic peptide (NT-proBNP) testing in the emergency department to rule out acute congestive heart failure (CHF) and the optimal cutpoints for this use are not established...
  29. ncbi Effects of n-3 polyunsaturated fatty acid therapy on plasma inflammatory markers and N-terminal pro-brain natriuretic peptide in elderly patients with chronic heart failure
    Y T Zhao
    Department of Cardiology, Shanghai East Hospital, Tongji University, Shanghai, China
    J Int Med Res 37:1831-41. 2009
    ..designed to investigate the effects of n-3 PUFA on circulating inflammatory markers and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with heart failure...
  30. doi Use of multiple biomarkers to improve the prediction of death from cardiovascular causes
    Bjorn Zethelius
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    N Engl J Med 358:2107-16. 2008
    ..The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been evaluated among the elderly...
  31. doi Brain natriuretic peptide for the prediction of sudden cardiac death and ventricular arrhythmias: a meta-analysis
    Paul A Scott
    Wessex Cardiothoracic Unit, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YD, UK
    Eur J Heart Fail 11:958-66. 2009
    The risk stratification of patients for sudden cardiac death (SCD) remains a challenge. Brain natriuretic peptide (BNP) predicts overall mortality in heart disease but it is unclear how well it predicts SCD...
  32. ncbi Brain natriuretic Peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases
    Toshihiro Tsuruda
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Circ Res 91:1127-34. 2002
    ..It is unknown if brain natriuretic peptide (BNP) is synthesized by CFs and if BNP participates in the regulation of extracellular matrix turnover...
  33. ncbi Amino-terminal pro-brain natriuretic peptide for the diagnosis of acute heart failure in patients with previous obstructive airway disease
    Roderick H Tung
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann Emerg Med 48:66-74. 2006
    We evaluate results from amino-terminal pro-brain natriuretic peptide (NT-proBNP) testing with or without those of clinical judgment for the evaluation of dyspneic patients with previous chronic obstructive pulmonary disease or asthma.
  34. ncbi Utility of B-type natriuretic peptide in predicting postoperative complications and outcomes in patients undergoing heart surgery
    Ryan Hutfless
    University of California, San Diego, San Diego, California, USA
    J Am Coll Cardiol 43:1873-9. 2004
    ..The purpose of the present study was to assess whether preoperative and postoperative B-type natriuretic peptide (BNP) levels could be used as predictors of postoperative complications and outcomes in patients after open-heart surgery...
  35. doi Brain Natriuretic Peptide (BNP) regulates the production of inflammatory mediators in human THP-1 macrophages
    V Chiurchiù
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Regul Pept 148:26-32. 2008
    b>Brain Natriuretic Peptide (BNP), besides retaining vasodilatory, diuretic and natriuretic properties, is a vasoactive hormone that it is also involved in several cardiac diseases as well as severe sepsis and septic shock...
  36. doi Prognostic significance of brain natriuretic peptide obtained in the ED in patients with SIRS or sepsis
    Yunxia Chen
    Emergency Department of China Rehabilitation Research Center, Beijing 100068, China
    Am J Emerg Med 27:701-6. 2009
    The study was conducted to know the significance of brain natriuretic peptide (BNP) for prognosis of septic patients.
  37. doi Regional clearance of amino-terminal pro-brain natriuretic peptide from human plasma
    Suetonia C Palmer
    Department of Medicine, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand
    Eur J Heart Fail 11:832-9. 2009
    Mechanisms for clearance of circulating amino-terminal pro-brain natriuretic peptide (NT-proBNP) remain poorly understood and are relevant to the clinical utility of NT-proBNP as a diagnostic and prognostic biomarker in cardiovascular ..
  38. doi Comparison of hand-carried ultrasound assessment of the inferior vena cava and N-terminal pro-brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated heart failure
    Sascha N Goonewardena
    University of Chicago Hospitals, Chicago, Illinois 60637, USA
    JACC Cardiovasc Imaging 1:595-601. 2008
    ..the value of serial assessment with hand-carried ultrasound (HCU) of the inferior vena cava (IVC) with brain natriuretic peptide (BNP) to identify patients with acute decompensated heart failure (ADHF) who will be readmitted or seek ..
  39. ncbi N-terminal pro-brain natriuretic peptide, kidney disease and outcome in patients with chronic heart failure
    Christian Bruch
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    J Heart Lung Transplant 25:1135-41. 2006
    In patients with chronic heart failure (CHF), N-terminal pro-brain natriuretic peptide (NT-proBNP) provides relevant prognostic information, but its usefulness in the presence of kidney disease has been questioned.
  40. ncbi Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial
    Franz Hartmann
    Medizinische Klinik II, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Circulation 110:1780-6. 2004
    ....
  41. pmc Relationship between serum brain natriuretic peptide and heart function in patients with chronic kidney disease
    Jae Won Yang
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
    Korean J Intern Med 23:191-200. 2008
    b>Brain natriuretic peptide (BNP) levels are known to be elevated in patients with chronic kidney disease (CKD) and normal heart function...
  42. pmc Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: relation to cardiovascular dysfunction and severity of disease
    J H Henriksen
    Department of Clinical Physiology, 239, Hvidovre Hospital, Hvidovre, Denmark
    Gut 52:1511-7. 2003
    ..to relate plasma concentrations of cardiac peptides reflecting early ventricular dysfunction (pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP)) to markers of severity of liver disease, cardiac ..
  43. ncbi Factors determining extreme brain natriuretic peptide elevation
    Maya Guglin
    Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Congest Heart Fail 13:136-41. 2007
    b>Brain natriuretic peptide (BNP) level is elevated in heart failure and reflects its severity. It is unknown why some patients have extremely high BNP levels...
  44. ncbi Essential biochemistry and physiology of (NT-pro)BNP
    Christian Hall
    Research Institute for Internal Medicine, University of Oslo, Rikshospitalet, 0037 Oslo, Norway
    Eur J Heart Fail 6:257-60. 2004
    b>Brain natriuretic peptide (BNP) is a 32 amino acid cardiac natriuretic peptide hormone originally isolated from porcine brain tissue. The human BNP gene is located on chromosome 1 and encodes the prohormone proBNP...
  45. ncbi Biological variation of N-terminal pro-brain natriuretic peptide in healthy individuals
    Gianvico Melzi d'Eril
    Clin Chem 49:1554-5. 2003
  46. pmc Assessment of cardiac risk before non-cardiac surgery: brain natriuretic peptide in 1590 patients
    J Dernellis
    Department of Cardiology, Vostanion Hospital, Mytilini, Greece
    Heart 92:1645-50. 2006
    To evaluate the predictive value of brain natriuretic peptide (BNP) for assessment of cardiac risk before non-cardiac surgery.
  47. ncbi Brain natriuretic peptide as a hormonal marker of ventricular diastolic dysfunction in children with Kawasaki disease
    S Kurotobi
    Department of Developmental Medicine, Pediatrics, D 5, Osaka University Graduate School of Medicine, 2 2 Yamada oka, 565 0871, Suita, Japan
    Pediatr Cardiol 26:425-30. 2005
    Although an increased level of serum brain natriuretic peptide (BNP) has been reported in children in the acute phase of Kawasaki disease (KD), no precise relation was documented between the serum BNP level and left ventricular (LV) ..
  48. pmc Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study
    James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Crit Care 10:R37. 2006
    Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in evaluating heart failure, but its role in evaluating patients with shock in the intensive care unit (ICU) is not clear.
  49. ncbi Abnormal tissue doppler images are associated with elevated plasma brain natriuretic peptide and increased oxidative stress in acute Kawasaki disease
    Daiji Takeuchi
    Department of Pediatric Cardiology, Tokyo Women s Medical University, Tokyo, Japan
    Circ J 71:357-62. 2007
    ..mechanics using pulsed tissue Doppler imaging (TDI), and to determine the relationship between abnormal myocardial performance and plasma brain natriuretic peptide (BNP) levels and oxidative stress in acute Kawasaki disease (KD).
  50. ncbi Atrial and brain natriuretic peptide and endothelin-1 concentration in patients with idiopathic arterial hypertension: the dependence on the selected morphological parameters
    Robert Irzmanski
    Department of Internal Diseases and Cardiological Rehabilitation, University Hospital, Medical University of Lodz, Lodz, Poland
    Clin Exp Hypertens 29:149-64. 2007
    The aim of the work was to study the maintenance of atrial and brain natriuretic peptide (ANP, BNP) and endothelin-1 (ET-1) in patients with idiopathic arterial hypertension and the relationships between cardiac morphological parameters ..
  51. pmc Increased N-terminal pro-brain natriuretic peptide level predicts atrial fibrillation after surgery for esophageal carcinoma
    Jiang Long Hou
    Department of Thoracic and Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 14:2582-5. 2008
    To evaluate the value of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) level for predicting postoperative atrial fibrillation (AF) in patients undergoing surgery for esophageal carcinoma.
  52. ncbi Plasma brain natriuretic peptide concentrations in patients with Kawasaki disease
    T Kawamura
    Department of Pediatrics, Hiroshima City Asa Hospital, Japan
    Pediatr Int 42:241-8. 2000
    b>Brain natriuretic peptide (BNP) is a cardiac hormone and plasma levels of it increase in patients with congestive heart failure and in those with acute myocardial infarction...
  53. ncbi Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals
    Thomas J Wang
    Cardiology Division, GRB 800, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Circulation 115:1345-53. 2007
    ..Although it has been shown that obese individuals have reduced natriuretic peptide levels, conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors...
  54. ncbi Brain natriuretic peptide can be a useful biochemical marker for myocarditis in patients with Kawasaki disease
    Takashi Kawamura
    Department of Pediatrics, Hiroshima City Asa Hospital, Japan
    Cardiol Young 12:153-8. 2002
    So as to determine the value of brain natriuretic peptide in the plasma as a biochemical marker for myocarditis of Kawasaki disease, we studied 69 patients...
  55. ncbi In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: an analysis from the Acute Decompensated Heart Failure National Registry (ADHERE)
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA
    J Am Coll Cardiol 46:57-64. 2005
    ..We sought to compare the in-hospital mortality of patients with acute decompensated heart failure (ADHF) who were receiving parenteral treatment with one of four intravenous vasoactive medications...
  56. ncbi Stability of N-terminal pro-brain natriuretic peptide after storage frozen for one year and after multiple freeze-thaw cycles
    William L Nowatzke
    Clin Chem 49:1560-2. 2003
  57. ncbi Comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP immunoassays in chronic and acute heart failure: a systematic review
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology, Department of Cardiovascular Medicine, Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Pisa, Italy
    Clin Chem 53:813-22. 2007
    We used evidence-based laboratory medicine principles to compare the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP (NT-proBNP) assays for the diagnosis of heart failure.
  58. ncbi Is a pre-operative brain natriuretic peptide or N-terminal pro-B-type natriuretic peptide measurement an independent predictor of adverse cardiovascular outcomes within 30 days of noncardiac surgery? A systematic review and meta-analysis of observational
    Ganesan Karthikeyan
    Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
    J Am Coll Cardiol 54:1599-606. 2009
    We conducted a systematic review and meta-analysis to determine if pre-operative brain natriuretic peptide (BNP) (i.e...
  59. ncbi B-type natriuretic peptide and renal function in the diagnosis of heart failure: an analysis from the Breathing Not Properly Multinational Study
    Peter A McCullough
    University of California, San Diego Veteran s Affairs Medical Center, San Diego, CA, USA
    Am J Kidney Dis 41:571-9. 2003
    ..However, relationships between BNP, renal function, and heart failure as an emergency diagnosis are unknown...
  60. pmc Left ventricular remodelling and brain natriuretic peptide after first myocardial infarction
    J G Crilley
    Department of Cardiology, Ward B22 Office, Sunderland Royal Hospital, Sunderland SR4 7TP, UK
    Heart 86:638-42. 2001
    To investigate the relation between brain natriuretic peptide (BNP) concentrations and left ventricular remodelling characteristics after acute myocardial infarction.
  61. ncbi Plasma brain natriuretic peptide and cardiac troponin I concentrations after adult cardiac surgery: association with postoperative cardiac dysfunction and 1-year mortality
    Sophie Provenchere
    département d anesthésie réanimation chirurgicale, Groupe Hospitalier Bichat Claude Bernard AP HP, Faculté Xavier Bichat Université Paris 7, France
    Crit Care Med 34:995-1000. 2006
    ..The purpose of the present study was to evaluate the prognostic implications of perioperative B-type natriuretic peptide (BNP) and cardiac troponin I concentrations in patients undergoing cardiopulmonary bypass for cardiac surgery...
  62. ncbi Comparison of the prognostic usefulness of N-terminal pro-brain natriuretic Peptide in patients with heart failure with versus without chronic kidney disease
    Christian Bruch
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Am J Cardiol 102:469-74. 2008
    In patients with chronic heart failure (CHF), N-terminal pro-brain natriuretic peptide (NT-pro-BNP) predicted poor outcome...
  63. ncbi Mitral annular motion as a surrogate for left ventricular function: correlation with brain natriuretic peptide levels
    Mohamed Fahmy Elnoamany
    Menofiya University, Egypt
    Eur J Echocardiogr 7:187-98. 2006
    ..b>Brain natriuretic peptide (BNP) levels have been shown to be elevated in patients with symptomatic LV dysfunction (Dys) and ..
  64. ncbi Brain natriuretic peptide and severity of disease in non-alcoholic cirrhotic patients
    Ramazan Yildiz
    Department of Internal Medicine, Division of Gastroenterology, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey
    J Gastroenterol Hepatol 20:1115-20. 2005
    ..They have insidious cardiac problems besides well-known complications. Brain natriuretic peptide (BNP) relaxes vascular smooth muscle and has a portal hypotensive action...
  65. ncbi Clinical applications of B-type natriuretic peptide (BNP) testing
    M R Cowie
    National Heart and Lung Institute, Imperial College, London, UK
    Eur Heart J 24:1710-8. 2003
    ..However, as BNP levels rise with age and are affected by gender, comorbidity and drug therapy, the plasma BNP measurement should not be used in isolation from the clinical context...
  66. ncbi N-terminal pro-brain natriuretic peptide, but not high sensitivity C-reactive protein, improves cardiovascular risk prediction in the general population
    Michael H Olsen
    Research Center for Prevention and Health, Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Eur Heart J 28:1374-81. 2007
    Serum N-terminal pro-brain natriuretic peptide (Nt-proBNP), high sensitivity (hs)-C-reactive protein, and urine albumin/creatinine ratio (UACR) are cardiovascular (CV) risk markers in the general population...
  67. ncbi B-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation
    Roberto Bassan
    Clínica São Vicente, R João Borges 204, Rio de Janeiro 22 451 100, Brazil
    Eur Heart J 26:234-40. 2005
    ..This study was undertaken to determine the diagnostic value of admission B-type natriuretic peptide (BNP) for acute myocardial infarction (AMI) in patients with acute chest pain and no ST-segment elevation...
  68. ncbi What is the normal range for N-terminal pro-brain natriuretic peptide? How well does this normal range screen for cardiovascular disease?
    Gavin I W Galasko
    Department of Cardiovascular Medicine, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Eur Heart J 26:2269-76. 2005
    To define the N-terminal pro-brain natriuretic peptide (NTpBNP) normal range, assessing its cardiovascular screening characteristics in general population and higher risk subjects.
  69. ncbi Troponin-T and N-terminal pro-B-type natriuretic peptide predict mortality benefit from coronary revascularization in acute coronary syndromes: a GUSTO-IV substudy
    Stefan K James
    Uppsala Clinical Research Center, Uppsala, Sweden
    J Am Coll Cardiol 48:1146-54. 2006
    ..This study was designed to evaluate biomarkers for selection of patients with non-ST-segment elevation acute coronary syndromes (ACS) that derive mortality benefit from revascularization...
  70. ncbi Optimal noninvasive assessment of left ventricular filling pressures: a comparison of tissue Doppler echocardiography and B-type natriuretic peptide in patients with pulmonary artery catheters
    Hisham Dokainish
    Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 109:2432-9. 2004
    ....
  71. ncbi N-terminal pro-brain natriuretic peptide on admission has prognostic value across the whole spectrum of acute coronary syndromes
    Marcello Galvani
    Ospedale G B Morgagni and Fondazione Sacco, Forli, Italy
    Circulation 110:128-34. 2004
    ..We measured N-terminal pro-brain natriuretic peptide (NT-proBNP) on admission in patients with ACS and ECG evidence of myocardial ischemia.
  72. doi Clinical relevance of a raised plasma N-terminal pro-brain natriuretic peptide level in a population-based cohort of nonagenarians
    Bert Vaes
    Department of General Practice, Universite Catholique de Louvain, Belgium
    J Am Geriatr Soc 57:823-9. 2009
    To investigate whether plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) remains a specific marker of cardiac illness in very old age and can be used to identify very elderly people at high risk for death independent of the ..
  73. pmc The accuracy of natriuretic peptides (brain natriuretic peptide and N-terminal pro-brain natriuretic) in the differentiation between transfusion-related acute lung injury and transfusion-related circulatory overload in the critically ill
    Guangxi Li
    Department of Guanganmen Hospital, Division of Pulmonary, China Academy of Chinese Medical Science, Beijing, China
    Transfusion 49:13-20. 2009
    ..b>Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic (NT-pro-BNP) accurately diagnosed TACO in preliminary studies ..
  74. ncbi Relation of coronary atherosclerosis determined by electron beam computed tomography and plasma levels of n-terminal pro-brain natriuretic peptide in a multiethnic population-based sample (the Dallas Heart Study)
    Shuaib M Abdullah
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Cardiol 96:1284-9. 2005
    ..In conclusion, these findings support the hypothesis that coronary atherosclerosis may directly influence the activation of the cardiac neurohormonal system...
  75. doi Chromogranin-A and N-terminal pro-brain natriuretic peptide: an excellent pair of biomarkers for diagnostics in patients with neuroendocrine tumor
    Catharina M Korse
    Department of Clinical Chemistry, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Clin Oncol 27:4293-9. 2009
    ..CgA) has been a well-established marker for neuroendocrine tumor (NET), and N-terminal pro-brain natriuretic peptide (NT-proBNP) has been a useful marker for left ventricular dysfunction...
  76. ncbi N-terminal pro-brain natriuretic peptide predicts cardiovascular events in patients with hypertension and left ventricular hypertrophy: a LIFE study
    Michael H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Glostrup, Denmark
    J Hypertens 22:1597-604. 2004
    N-terminal pro-brain natriuretic peptide (Nt-proBNP) and N-terminal pro-atrial natriuretic peptide (Nt-proANP) are strong cardiovascular risk markers in patients with chronic heart failure, as well as in the general population...
  77. ncbi Effect of sinus rhythm restoration after electrical cardioversion on apelin and brain natriuretic Peptide prohormone levels in patients with persistent atrial fibrillation
    Eleftherios M Kallergis
    Department of Cardiology, University Hospital of Heraklion, Heraklion, Crete, Greece
    Am J Cardiol 105:90-4. 2010
    ..Levels of plasma apelin and amino terminal fragment of the brain natriuretic peptide prohormone (NT-pro-BNP) were measured in 40 patients with persistent AF, before and 1 month after ..
  78. ncbi Myocardial stiffness is an important determinant of the plasma brain natriuretic peptide concentration in patients with both diastolic and systolic heart failure
    Satoshi Watanabe
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University, Graduate School of Medicine, Chuo Ku, Japan
    Eur Heart J 27:832-8. 2006
    Plasma brain natriuretic peptide (BNP) concentration increases in proportion to heart failure (HF) severity...
  79. ncbi Predictive value of N-terminal pro-brain natriuretic peptide in severe sepsis and septic shock
    Marjut Varpula
    Department of Surgery, Helsinki University Hospital, Finland
    Crit Care Med 35:1277-83. 2007
    The aim of this study was to evaluate the predictive value of N-terminal pro-brain natriuretic peptide (NT-proBNP) on mortality in a large, unselected patient population with severe sepsis and septic shock.
  80. ncbi N-terminal pro-brain natriuretic peptide, C-reactive protein, and urinary albumin levels as predictors of mortality and cardiovascular events in older adults
    Caroline Kistorp
    Department of Cardiology and Endocrinology, Frederiksberg University Hospital, Copenhagen, Denmark
    JAMA 293:1609-16. 2005
    ....
  81. doi Prognostic importance of increased plasma amino-terminal pro-brain natriuretic peptide levels in a large noncardiac, general intensive care unit population
    Anastasia Kotanidou
    First Department of Critical Care Medicine, Evangelismos Hospital, Athens, Greece
    Shock 31:342-7. 2009
    The present study aimed to determine whether amino-terminal pro-brain natriuretic peptide (NT-pro-BNP) predicts intensive care unit (ICU) mortality in a cohort of general, noncardiac, critically ill patients...
  82. ncbi Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure
    Guido Boerrigter
    Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hypertension 49:1128-33. 2007
    ..These beneficial properties make direct soluble guanylate cyclase stimulation with BAY 58-2667 a promising new therapeutic strategy for cardiovascular diseases, such as heart failure...
  83. doi Brain natriuretic peptide and N-terminal pro-B-type natriuretic peptide show a different profile in response to acute decompensated heart failure treatment
    Salvatore Di Somma
    Emergency Medicine Department, II Medical School University La Sapienza, Sant Andrea Hospital, Rome, Italy
    Congest Heart Fail 14:245-50. 2008
    b>Brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are currently used for the diagnosis, prognosis, and therapeutic decision making in heart failure patients...
  84. ncbi Plasma level of N terminal pro-brain natriuretic peptide as a prognostic marker in critically ill patients
    Yaniv Almog
    Medical Intensive Care Unit and the Department of Medicine, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    Anesth Analg 102:1809-15. 2006
    We studied whether N-terminal pro brain natriuretic peptide (NT-pro BNP) measured at intensive care unit admission is an independent predictor of mortality in critically ill patients...
  85. ncbi Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations
    R W Troughton
    Christchurch Cardioendocrine Research Group, Christchurch Hospital, New Zealand
    Lancet 355:1126-30. 2000
    ..We hypothesised that pharmacotherapy guided by plasma concentrations of the cardiac peptide aminoterminal brain natriuretic peptide (N-BNP) would produce a superior outcome to empirical trial-based therapy dictated by clinical acumen.
  86. doi What is the value of B-type natriuretic peptide testing for diagnosis, prognosis or monitoring of critically ill adult patients in intensive care?
    Robert H Christenson
    Department of Pathology and Medical and Research Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Chem Lab Med 46:1524-32. 2008
    ..Clinical use of these biomarkers in critically ill patients being treated in intensive care is not well established...
  87. ncbi The influence of atorvastatin on parameters of inflammation and function of the left ventricle in patients with dilated cardiomyopathy
    Agata Bielecka-Dabrowa
    Department of Hypertension, Medical University of Łódź, Łódź, Poland
    Med Sci Monit 15:MS12-23. 2009
    ..We assessed the influence of atorvastatin on selected indicators of an inflammation, function of the left ventricle and factors affecting the occurrence of rehospitalisation and mortality in patients with dilated cardiomyopathy (DCM)...
  88. ncbi NT-proBNP can be used to detect right ventricular systolic dysfunction in pulmonary hypertension
    K G Blyth
    Scottish Pulmonary Vascular Unit, University of Glasgow, Glasgow G11 6NT, UK
    Eur Respir J 29:737-44. 2007
    ..N-terminal B-type natriuretic peptide could prove useful as an objective, noninvasive means of identifying patients with pulmonary hypertension who have right ventricular systolic dysfunction at presentation...
  89. ncbi Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
    Alan S Maisel
    University of California, San Diego, Veterans Affairs Medical Center, San Diego 92161, USA
    N Engl J Med 347:161-7. 2002
    ..B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension...
  90. ncbi Effects of intravenous nesiritide on human coronary vasomotor regulation and myocardial oxygen uptake
    Andrew D Michaels
    Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, 505 Parnassus Ave, Box 0124, San Francisco, Calif 94143 0124, USA
    Circulation 107:2697-701. 2003
    ..Nesiritide, recombinant human B-type natriuretic peptide, has been shown to be efficacious in the treatment of decompensated heart failure. The effects of intravenous nesiritide on the human coronary vasculature have not been studied...
  91. ncbi Effect of beta blockade (carvedilol or metoprolol) on activation of the renin-angiotensin-aldosterone system and natriuretic peptides in chronic heart failure
    Jeffrey W H Fung
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China
    Am J Cardiol 92:406-10. 2003
    ..These results indicate that the suppressive effect of beta blockers on PRA in patients with HF taking ACE inhibitors is temporary, and that there is no significant effect on serum aldosterone levels...
  92. ncbi Relationship between insulin-like growth factor-I and brain natriuretic peptide in patients with acromegaly after surgery
    Masahiro Ito
    Division of Cardiology, Department of Neurosurgery, Brain Institute, Niigata University School of Medicine, Japan
    Circ J 71:1955-7. 2007
    ..On the other hand, acromegaly which is characterized by an excess of IGF-I has been linked to impaired cardiac function...
  93. ncbi Role of the plasma brain natriuretic peptide in differentiating patients with congestive heart failure from other diseases
    Chirasak Sirithunyanont
    Bangkok Heart Institute, Bangkok Hospital, Bangkok 10320, Thailand
    J Med Assoc Thai 86:S87-95. 2003
    ..Recently, there has been evidence of the role of brain natriuretic peptide (BNP) and its use in HF concerning diagnosis, prognosis, and treatment follow-up...
  94. ncbi The brain natriuretic peptide (BNP) precursor is the major immunoreactive form of BNP in patients with heart failure
    Karina R Seferian
    HyTest Ltd, Turku, Finland
    Clin Chem 53:866-73. 2007
    Peptides derived from brain natriuretic peptide (BNP) precursor (proBNP), BNP, and the N-terminal fragment of proBNP (NT-proBNP) are used as biomarkers of heart failure...
  95. ncbi Effects of tai chi mind-body movement therapy on functional status and exercise capacity in patients with chronic heart failure: a randomized controlled trial
    Gloria Y Yeh
    Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Med 117:541-8. 2004
    ..To examine the effects of a 12-week tai chi program on quality of life and exercise capacity in patients with heart failure...
  96. ncbi Incremental prognostic value of changes in B-type natriuretic peptide in heart failure
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Am J Med 119:70.e23-30. 2006
    ..We hypothesized that B-type natriuretic peptide changes during treatment of heart failure may provide independent information on disease progression and outcome in patients enrolled in the Val-HeFT trial...
  97. ncbi PGE2 stimulates human brain natriuretic peptide expression via EP4 and p42/44 MAPK
    Jian Yong Qian
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 2689, USA
    Am J Physiol Heart Circ Physiol 290:H1740-6. 2006
    b>Brain natriuretic peptide (BNP) produced by cardiac myocytes has antifibrotic and antigrowth properties and is a marker of cardiac hypertrophy...
  98. ncbi Brain natriuretic peptide concentration in dogs with heart disease and congestive heart failure
    Kristin A MacDonald
    Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA, USA
    J Vet Intern Med 17:172-7. 2003
    Plasma brain natriuretic peptide concentration ([BNP]) is high in humans with cardiac disease and is further increased with congestive heart failure (CHF)...
  99. ncbi Plasma brain natriuretic peptide and the evaluation of volume overload in infants and children with congenital heart disease
    Yoko Kunii
    Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Acta Med Okayama 57:191-7. 2003
    ..designed to explore whether it was possible to evaluate the severity of VSD, PDA, and ASD by measuring brain natriuretic peptide (BNP) levels. We also investigated normal BNP levels in children to provide a baseline for our study...
  100. ncbi Functional assessment by myocardial performance index (Tei index) correlates with plasma brain natriuretic peptide concentration in patients with hypertrophic cardiomyopathy
    Makoto Okawa
    Department of Medicine and Geriatrics, Kochi Medical School, Kochi, Japan
    Circ J 69:951-7. 2005
    ..Plasma brain natriuretic peptide (BNP) level is reported to be elevated in HCM, but the mechanism of BNP elevation in HCM remains to be ..
  101. ncbi N-terminal pro brain natriuretic peptide: the new cornerstone of cardiovascular assessment in systemic sclerosis
    Y Allanore
    Department of Rheumatology A, Cochin Hospital, Paris Descartes University, Paris, France
    Clin Exp Rheumatol 27:59-63. 2009
    ....

Research Grants80

  1. Testing a Measurement Model of Acute Dyspnea
    Mark Parshall; Fiscal Year: 2005
    ....
  2. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 1999
    ..that are homozygous for a mutation that diminishes production of both atrial natriuretic peptide and brain natriuretic peptide have significantly increased IOP...
  3. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2001
    ..that are homozygous for a mutation that diminishes production of both atrial natriuretic peptide and brain natriuretic peptide have significantly increased IOP...
  4. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2000
    ..that are homozygous for a mutation that diminishes production of both atrial natriuretic peptide and brain natriuretic peptide have significantly increased IOP...
  5. Coping Skills Training in Heart Failure: Outcomes and Mechanisms
    Andrew Sherwood; Fiscal Year: 2009
    ....
  6. Coping Skills Training in Heart Failure: Outcomes and Mechanisms
    Andrew Sherwood; Fiscal Year: 2010
    ....
  7. Molecular mechanism of senile cardiac amyloidosis
    Lawreen H Connors; Fiscal Year: 2010
    ..in patient sera at baseline and annually for 3 years and correlating results with cardiac troponin I, brain natriuretic peptide, left ventricular (LV) end-diastolic and end-systolic diameters, and LV ejection fraction as measures of ..
  8. Molecular mechanism of senile cardiac amyloidosis
    Lawreen Connors; Fiscal Year: 2009
    ..in patient sera at baseline and annually for 3 years and correlating results with cardiac troponin I, brain natriuretic peptide, left ventricular (LV) end-diastolic and end-systolic diameters, and LV ejection fraction as measures of ..
  9. Point-of-care system based on single polymer nanowires for real-time, AMI diagnos
    Minhee Yun; Fiscal Year: 2009
    ....
  10. Point-of-care system based on single polymer nanowires for real-time, AMI diagnos
    Minhee Yun; Fiscal Year: 2010
    ....
  11. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2004
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  12. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2005
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  13. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2006
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  14. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2007
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  15. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2006
    ..converting enzyme inhibitors and diuretics (Medication Event Monitoring System), heart failure severity (brain natriuretic peptide levels), functional ability (6 minute walk distance), HF patient depressive symptoms (Beck Depression ..
  16. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2007
    ..converting enzyme inhibitors and diuretics (Medication Event Monitoring System), heart failure severity (brain natriuretic peptide levels), functional ability (6 minute walk distance), HF patient depressive symptoms (Beck Depression ..
  17. CORE--MUTANT MOUSE
    Edward Shesely; Fiscal Year: 2002
    ..A colony of transgenic mice with brain natriuretic peptide promoter-driven luciferase expression (BNP-Luc) is available...
  18. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2005
    ..converting enzyme inhibitors and diuretics (Medication Event Monitoring System), heart failure severity (brain natriuretic peptide levels), functional ability (6 minute walk distance), HF patient depressive symptoms (Beck Depression ..
  19. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2009
    ..converting enzyme inhibitors and diuretics (Medication Event Monitoring System), heart failure severity (brain natriuretic peptide levels), functional ability (6 minute walk distance), HF patient depressive symptoms (Beck Depression ..
  20. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2004
    ..converting enzyme inhibitors and diuretics (Medication Event Monitoring System), heart failure severity (brain natriuretic peptide levels), functional ability (6 minute walk distance), HF patient depressive symptoms (Beck Depression ..
  21. Plasmon-Controlled Fluorescence and Cardiac Markers
    Joseph Lakowicz; Fiscal Year: 2009
    ..Cardiac troponin I and BMP are present at lower concentrations and their detection will drive development of nanostructures for high sensitivity detection. ..
  22. Plasmon-Controlled Fluorescence and Cardiac Markers
    Joseph Lakowicz; Fiscal Year: 2007
    ..Cardiac troponin I and BMP are present at lower concentrations and their detection will drive development of nanostructures for high sensitivity detection. ..
  23. Identifiction of the natriuretic peptide receptor kinase
    LINCOLN POTTER; Fiscal Year: 2009
    ..The goal of this grant is to identify this critical molecule so that it can be targeted by novel drugs designed to treat cardiovascular and skeletal diseases. ..
  24. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2004
    ..In response to increased blood pressure, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted from the heart and stimulate vasorelaxation and fluid loss. On the other hand...
  25. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2003
    ..In response to increased blood pressure, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted from the heart and stimulate vasorelaxation and fluid loss. On the other hand...
  26. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2005
    ..In response to increased blood pressure, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted from the heart and stimulate vasorelaxation and fluid loss. On the other hand...
  27. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2002
    ..In response to increased blood pressure, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted from the heart and stimulate vasorelaxation and fluid loss. On the other hand...
  28. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2006
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on heart failure. ..
  29. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2004
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on heart failure. ..
  30. ATP-MODULATED SIGNAL TRANSDUCTION MECHANISM OF ANF-RGC
    Teresa Duda; Fiscal Year: 2007
    ..The proposed studies are most fundamental in nature, yet they are directly applicable to the molecular understanding the disease processes resulting in hypertension, heart dystrophy, water balance and fluid secretion. ..
  31. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2005
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on heart failure. ..
  32. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2003
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on heart failure. ..
  33. ATP-MODULATED SIGNAL TRANSDUCTION MECHANISM OF ANF-RGC
    Teresa Duda; Fiscal Year: 2010
    ..The proposed studies are most fundamental in nature, yet they are directly applicable to the molecular understanding the disease processes resulting in hypertension, heart dystrophy, water balance and fluid secretion. ..
  34. ATP-MODULATED SIGNAL TRANSDUCTION MECHANISM OF ANF-RGC
    Teresa Duda; Fiscal Year: 2009
    ..The proposed studies are most fundamental in nature, yet they are directly applicable to the molecular understanding the disease processes resulting in hypertension, heart dystrophy, water balance and fluid secretion. ..
  35. ATP-MODULATED SIGNAL TRANSDUCTION MECHANISM OF ANF-RGC
    Teresa Duda; Fiscal Year: 2009
    ..The proposed studies are most fundamental in nature, yet they are directly applicable to the molecular understanding the disease processes resulting in hypertension, heart dystrophy, water balance and fluid secretion. ..
  36. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 2002
    ..Atrial natriuretic peptide (ANP) is preferentially expressed in the cardiac atria while brain natriuretic peptide (BNP) expression shows a more equivalent distribution in atrial and ventricular myocytes...
  37. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 2001
    ..Atrial natriuretic peptide (ANP) is preferentially expressed in the cardiac atria while brain natriuretic peptide (BNP) expression shows a more equivalent distribution in atrial and ventricular myocytes...
  38. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 2000
    ..Atrial natriuretic peptide (ANP) is preferentially expressed in the cardiac atria while brain natriuretic peptide (BNP) expression shows a more equivalent distribution in atrial and ventricular myocytes...
  39. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2007
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on heart failure. ..
  40. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 1999
    ..Atrial natriuretic peptide (ANP) is preferentially expressed in the cardiac atria while brain natriuretic peptide (BNP) expression shows a more equivalent distribution in atrial and ventricular myocytes...
  41. Regulated Long-Term Cardiac BNP Expression in Hypertensive Heart Disease
    YASUHIRO contact IKEDA; Fiscal Year: 2010
    ..We will test if regulated long-term cardiac BNP expression ameliorates HHD. Our results will elucidate the role of BNP in hypertension and may lead to a novel chronic BNP therapy strategy for human HHD. ..
  42. Natriuretic Peptide System as Therapy in Human Preclinical LV Dysfunction
    Horng Chen; Fiscal Year: 2009
    ..Acute peptide therapy with brain natriuretic peptide (BNP) infusion has recently been approved by the FDA as a therapeutic strategy for the treatment of ..
  43. SPR Imaging Studies of Nucleic Acid Microarrays for Biomarker Detection
    ROBERT CORN; Fiscal Year: 2009
    ....
  44. SPR Imaging Studies of Nucleic Acid Microarrays for Biomarker Detection
    Robert M Corn; Fiscal Year: 2010
    ....
  45. SPR Imaging Studies of Nucleic Acid Microarrays for Biomarker Detection
    ROBERT CORN; Fiscal Year: 2007
    ....
  46. ANP as Therapy in Human Preclinical LV Dysfunction
    Horng Chen; Fiscal Year: 2005
    ..Acute peptide therapy with brain natriuretic peptide (BNP) infusion has recently been approved by the FDA as a therapeutic strategy for the treatment of ..
  47. PREVALENCE OF ASYMPTOMATIC VENTRICULAR DYSFUNCTION
    Richard Rodeheffer; Fiscal Year: 2003
    ..has shown that both systolic and diastolic LVD are associated with elevated plasma concentrations of brain natriuretic peptide (BNP), a peptide secreted by the heart in response to increased cardiac filling pressure, that may serve ..
  48. PREVALENCE OF ASYMPTOMATIC VENTRICULAR DYSFUNCTION
    Richard Rodeheffer; Fiscal Year: 2001
    ..has shown that both systolic and diastolic LVD are associated with elevated plasma concentrations of brain natriuretic peptide (BNP), a peptide secreted by the heart in response to increased cardiac filling pressure, that may serve ..
  49. PREVALENCE OF ASYMPTOMATIC VENTRICULAR DYSFUNCTION
    Richard Rodeheffer; Fiscal Year: 2002
    ..has shown that both systolic and diastolic LVD are associated with elevated plasma concentrations of brain natriuretic peptide (BNP), a peptide secreted by the heart in response to increased cardiac filling pressure, that may serve ..
  50. PREVALENCE OF ASYMPTOMATIC VENTRICULAR DYSFUNCTION
    Richard Rodeheffer; Fiscal Year: 2004
    ..has shown that both systolic and diastolic LVD are associated with elevated plasma concentrations of brain natriuretic peptide (BNP), a peptide secreted by the heart in response to increased cardiac filling pressure, that may serve ..
  51. VASOACTIVE AUTACOIDS IN BLOOD PRESSURE REGULATION
    Oscar Carretero; Fiscal Year: 1999
    ..EDCF), and eicosanoids, in synergism with endocrine hormones such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP), act by opposing hypertensive stimuli, and b) their blockade results in high BP or accelerated ..
  52. VASOACTIVE AUTACOIDS IN BLOOD PRESSURE REGULATION
    Oscar Carretero; Fiscal Year: 2000
    ..EDCF), and eicosanoids, in synergism with endocrine hormones such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP), act by opposing hypertensive stimuli, and b) their blockade results in high BP or accelerated ..
  53. VASOACTIVE AUTACOIDS IN BLOOD PRESSURE REGULATION
    Oscar Carretero; Fiscal Year: 2001
    ..EDCF), and eicosanoids, in synergism with endocrine hormones such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP), act by opposing hypertensive stimuli, and b) their blockade results in high BP or accelerated ..
  54. PREDICTORS OF RECURRENT STROKE IN THE PROGRESS STUDY
    Duncan Campbell; Fiscal Year: 2002
    ..In addition, plasma markers that predict risk of recurrent stroke may indicate novel therapies to prevent this condition. ..
  55. REGULATION OF NITRIC OXIDE SYNTASE IN CARDIAC MYOCYTES
    MARGOT LAPOINTE; Fiscal Year: 1999
    Atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) have vasodepressor effects, while in the kidney they have potent natriuretic and diuretic activities...
  56. REGULATION OF NITRIC OXIDE SYNTASE IN CARDIAC MYOCYTES
    MARGOT LAPOINTE; Fiscal Year: 2001
    Atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) have vasodepressor effects, while in the kidney they have potent natriuretic and diuretic activities...
  57. REGULATION OF NITRIC OXIDE SYNTASE IN CARDIAC MYOCYTES
    MARGOT LAPOINTE; Fiscal Year: 2000
    Atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) have vasodepressor effects, while in the kidney they have potent natriuretic and diuretic activities...
  58. VASOACTIVE HORMONES IN BLOOD PRESSURE REGULATION
    Oscar Carretero; Fiscal Year: 1992
    ..EDCF), and eicosanoids, in synergism with endocrine hormones such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP), act by opposing hypertensive stimuli, and b) their blockade results in high BP or accelerated ..
  59. PREDICTORS OF RECURRENT STROKE IN THE PROGRESS STUDY
    Duncan Campbell; Fiscal Year: 2003
    ..In addition, plasma markers that predict risk of recurrent stroke may indicate novel therapies to prevent this condition. ..
  60. Cardiovascular Status of HAART-Exposed Infants/Children
    Steven Lipshultz; Fiscal Year: 2005
    ..determine how left ventricular (LV) structure and function, serum cardiac troponin T (cTnT), serum pro brain natriuretic peptide (proBNP), and serum high sensitivity C reactive protein (hsCRP) are affected by HAART exposure...
  61. MOLECULAR PATHWAYS CONTROLLING CARDIAC GENE EXPRESSION
    Jeffery Molkentin; Fiscal Year: 1999
    ..genes such as the alpha-myosin heavy chain, cardiac troponin-C, atrial natriuretic factor, and brain natriuretic peptide. Recent investigations have also directly implicated GATA4 as a transcriptional regulator of the ..
  62. MOLECULAR PATHWAYS CONTROLLING CARDIAC GENE EXPRESSION
    Jeffery Molkentin; Fiscal Year: 2000
    ..genes such as the alpha-myosin heavy chain, cardiac troponin-C, atrial natriuretic factor, and brain natriuretic peptide. Recent investigations have also directly implicated GATA4 as a transcriptional regulator of the ..
  63. Cardiovascular Status of HAART-Exposed Infants/Children
    Steven Lipshultz; Fiscal Year: 2003
    ..determine how left ventricular (LV) structure and function, serum cardiac troponin T (cTnT), serum pro brain natriuretic peptide (proBNP), and serum high sensitivity C reactive protein (hsCRP) are affected by HAART exposure...
  64. Cardiovascular Status of HAART-Exposed Infants/Children
    Steven Lipshultz; Fiscal Year: 2004
    ..determine how left ventricular (LV) structure and function, serum cardiac troponin T (cTnT), serum pro brain natriuretic peptide (proBNP), and serum high sensitivity C reactive protein (hsCRP) are affected by HAART exposure...
  65. Cardiovascular Status of HAART-Exposed Infants/Children
    Steven Lipshultz; Fiscal Year: 2003
    ..determine how left ventricular (LV) structure and function, serum cardiac troponin T (cTnT), serum pro brain natriuretic peptide (proBNP), and serum high sensitivity C reactive protein (hsCRP) are affected by HAART exposure...
  66. MOLECULAR PATHWAYS CONTROLLING CARDIAC GENE EXPRESSION
    Jeffery Molkentin; Fiscal Year: 2001
    ..genes such as the alpha-myosin heavy chain, cardiac troponin-C, atrial natriuretic factor, and brain natriuretic peptide. Recent investigations have also directly implicated GATA4 as a transcriptional regulator of the ..
  67. Cardiovascular Status of HAART-Exposed Infants/Children
    Steven Lipshultz; Fiscal Year: 2002
    ..determine how left ventricular (LV) structure and function, serum cardiac troponin T (cTnT), serum pro brain natriuretic peptide (proBNP), and serum high sensitivity C reactive protein (hsCRP) are affected by HAART exposure...
  68. Cardiovascular Status of HAART-Exposed Infants/Children
    Steven Lipshultz; Fiscal Year: 2006
    ..determine how left ventricular (LV) structure and function, serum cardiac troponin T (cTnT), serum pro brain natriuretic peptide (proBNP), and serum high sensitivity C reactive protein (hsCRP) are affected by HAART exposure...
  69. External Counterpulsation in Acute Coronary Syndrome
    Andrew Michaels; Fiscal Year: 2004
    ....
  70. External Counterpulsation in Acute Coronary Syndrome
    Andrew Michaels; Fiscal Year: 2007
    ....
  71. MOLECULAR PATHWAYS CONTROLLING CARDIAC GENE EXPRESSION
    Jeffery Molkentin; Fiscal Year: 2002
    ..genes such as the alpha-myosin heavy chain, cardiac troponin-C, atrial natriuretic factor, and brain natriuretic peptide. Recent investigations have also directly implicated GATA4 as a transcriptional regulator of the ..
  72. REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLS
    David Gardner; Fiscal Year: 2005
    ..NPR-A binds to two cardiac hormones, atrial and brain natriuretic peptide (ANP and BNP, respectively) while NPR-B associates predominantly with the C-type natriuretic peptide (..
  73. REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLS
    David Gardner; Fiscal Year: 2002
    ..NPR-A binds to two cardiac hormones, atrial and brain natriuretic peptide (ANP and BNP, respectively) while NPR-B associates predominantly with the C-type natriuretic peptide (..
  74. REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLS
    David Gardner; Fiscal Year: 2004
    ..NPR-A binds to two cardiac hormones, atrial and brain natriuretic peptide (ANP and BNP, respectively) while NPR-B associates predominantly with the C-type natriuretic peptide (..
  75. Protein Therapeutics to Prevent Heart Failure Post Myocardial Infarction
    Horng H Chen; Fiscal Year: 2010
    ..This research will aid in addressing this health challenge. ..
  76. Mentored Patient-Oriented Research Career Development Award
    Andrew Michaels; Fiscal Year: 2006
    ....
  77. Mentored Patient-Oriented Research Career Development Award
    Andrew Michaels; Fiscal Year: 2005
    ....
  78. CARDIOVASCULAR STRESS OF SLEEP APNEA AND HEART FAILURE
    Alan Schwartz; Fiscal Year: 2005
    ..abstract_text> ..
  79. CARDIOVASCULAR STRESS OF SLEEP APNEA AND HEART FAILURE
    Alan Schwartz; Fiscal Year: 2003
    ..abstract_text> ..