Genomes and Genes
Summary: A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to PLASMIN. They are concentrated in the lysosomes of most cells and in the vascular endothelium, particularly in the vessels of the microcirculation.
Publications281 found, 100 shown here
- Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymographyAlejandro Curino
Proteases and Tissue Remodeling Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA
Oral Oncol 40:1026-32. 2004..In conclusion, LCM combined with zymography may be excellently suited for analyzing the prognostic significance and causal involvement of the plasminogen activation system in oral cancer...
- Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damageD Gveric
Department of Neurochemistry, Institute of Neurology, University College London, UK
Brain 124:1978-88. 2001..tPA localization on injured axons may be a marker of axonal damage or represent a protective mechanism aimed at removal of fibrin deposits and restoration of axonal function...
- The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombinT Osterwalder
Institute of Biochemistry, University of Zurich, Switzerland
J Biol Chem 273:2312-21. 1998..Although neuroserpin bound and inactivated plasminogen activators and plasmin, no interaction was observed with thrombin...
- A proposed reference method for plasminogen activators that enables calculation of enzyme activities in SI unitsC Longstaff
Division of Haematology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK
J Thromb Haemost 2:1416-21. 2004A method has been developed for accurately and precisely measuring the activity of a range of plasminogen activators (PAs) used as thrombolytic agents, including streptokinase, tissue plasminogen activator (tPA) and variants, and ..
- Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective mannerD H Nguyen
Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
J Cell Biol 146:149-64. 1999..Thus, we have demonstrated that uPA promotes cellular migration, in an integrin-selective manner, by initiating a uPAR-dependent signaling cascade in which Ras, MEK, ERK, and MLCK serve as essential downstream effectors...
- Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinasesEng H Lo
Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Neurosci Res 69:1-9. 2002..As the mechanisms of deleterious vs. potentially beneficial PA and MMP actions become better defined, it is hoped that new therapeutic targets will emerge for ameliorating the sequelae of brain injury and inflammation...
- Accelerating thrombolysis with chitosan-coated plasminogen activators encapsulated in poly-(lactide-co-glycolide) (PLGA) nanoparticlesTze Wen Chung
Department of Chemical Engineering, National Yunlin University of Science and Technology, Tou Liu, Yunlin, Taiwan, ROC
Biomaterials 29:228-37. 2008Accelerating thrombolysis using plasminogen activators (PAs) encapsulated liposomes or PEG microparticles by pressure-driven permeation have been demonstrated in vitro and in vivo in animal models...
- A urokinase receptor-associated protein with specific collagen binding propertiesN Behrendt
Finsen Laboratory, Rigshospitalet, DK 2100 Copenhagen O, Denmark
J Biol Chem 275:1993-2002. 2000..This collagen binding reaction at the exact site of plasminogen activation on the cell may lead to adhesive functions as well as a contribution to cellular degradation of collagen matrices...
- Structural basis for activation of an integral membrane protease by lipopolysaccharideElif Eren
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 287:23971-6. 2012....
- Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49aS B Hawley
Department of Vascular Biology CVN 26, Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 276:179-86. 2001..These results suggest that TIP49a is a previously unrecognized plasminogen-binding protein on the U937 cell surface...
- Plasminogen activation and cancerKeld Danø
Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
Thromb Haemost 93:676-81. 2005..Therefore for each type of cancer, a combination of protease inhibitors that is optimised with respect to both maximal therapeutic effect and minimal toxic side effects need to be identified...
- The plasminogen activation system in tumor growth, invasion, and metastasisP A Andreasen
Department of Molecular and Structural Biology, Aarhus University, Denmark
Cell Mol Life Sci 57:25-40. 2000..plasminogen can be catalyzed by either of two other serine proteinases, the urokinase- and tissue-type plasminogen activators (uPA and tPA)...
- The plasminogen activator system: biology and regulationJ P Irigoyen
Friedrich Miescher Institute, Basel, Switzerland
Cell Mol Life Sci 56:104-32. 1999The regulation of plasminogen activation involves genes for two plasminogen activators (tissue type and urokinase type), two specific inhibitors (type 1 and type 2), and a membrane-anchored urokinase-type plasminogen-activator-specific ..
- An active site water network in the plasminogen activator pla from Yersinia pestisElif Eren
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Structure 18:809-18. 2010..The Pla structure suggests a model for the interaction with plasminogen substrate and provides a more detailed understanding of the catalytic mechanism of omptin proteases...
- Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin functionD I Simon
Cardiovascular, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 275:10228-34. 2000....
- Plasminogen enhances neuritogenesis on laminin-1Ana Gutierrez-Fernandez
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Neurosci 29:12393-400. 2009..This study provides the first direct evidence that plasminogen participates in neurite outgrowth and also suggests that laminin-1 degradation by plasmin contributes to the process of neuritogenesis...
- Cell-surface actin binds plasminogen and modulates neurotransmitter release from catecholaminergic cellsLindsey A Miles
Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, California, 92037, USA
J Neurosci 26:13017-24. 2006..Our results suggest that cell-surface-expressed forms of actin bind plasminogen, thereby promoting plasminogen activation and increased prohormone processing leading to inhibition of neurotransmitter release...
- Plasminogen activator Pla of Yersinia pestis utilizes murine DEC-205 (CD205) as a receptor to promote disseminationShu sheng Zhang
Department of Biomedical Sciences, College of Medicine Rockford, University of Illinois at Chicago, Rockford, Illinois 61107, USA
J Biol Chem 283:31511-21. 2008..pestis in mice. In conclusion, murine DEC-205 is a receptor for PLA of Y. pestis, and this host-pathogen interaction appears to play a key role in promoting bacterial dissemination...
- The single substitution I259T, conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches, enhances fibrinolytic activityJohanna Haiko
General Microbiology, Faculty of Biosciences, FI 00014 University of Helsinki, Finland
J Bacteriol 191:4758-66. 2009..The results suggest that Microtus Pla represents an ancestral form of Pla that has evolved into a more efficient plasminogen activator in the pandemic Y. pestis lineages...
- Physiological consequences of loss of plasminogen activator gene function in miceP Carmeliet
Whitehead Institute of Biomedical Research, Cambridge, Massachusetts 02142
Nature 368:419-24. 1994..Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival...
- Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectinL Kjøller
Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, United Kingdom
J Cell Biol 152:1145-57. 2001..This mechanism may play a role in uPAR-mediated regulation of cell motility at sites where VN and uPAR are co-expressed, such as malignant tumors...
- Reduced metastasis of transgenic mammary cancer in urokinase-deficient miceKasper Almholt
Finsen Laboratory, Rigshospitalet 8621, Strand boulevarden 49, DK 2100 Copenhagen, Denmark
Int J Cancer 113:525-32. 2005..We show that metastasis is strongly and selectively decreased in uPA-deficient mice, suggesting that uPA-directed antimetastatic therapy would be efficacious and have limited side effects...
- Activation of pro-matrix metalloproteinase-9 and degradation of gelatin by the surface protease PgtE of Salmonella enterica serovar TyphimuriumPäivi Ramu
General Microbiology, Department of Biological and Environmental Sciences, Faculty of Biosciences, University of Helsinki, PO Box 56, FIN 00014 Helsinki, Finland
Int J Med Microbiol 298:263-78. 2008..Our results indicate that PgtE and Pla have diverged in substrate specificity, and suggest that Salmonella PgtE has evolved to functionally mimic mammalian MMPs...
- Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activitySarah Netzel-Arnett
Matrix Metalloproteinase Unit, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:45154-61. 2002..We propose that plasminogen activation facilitates keratinocyte-mediated collagen breakdown via the direct activation of matrix metalloproteinase-13 and possibly other fibrillar collagenases...
- Invited review: Breaking barriers--attack on innate immune defences by omptin surface proteases of enterobacterial pathogensJohanna Haiko
General Microbiology, Faculty of Biosciences, University of Helsinki, Helsinki, Finland
Innate Immun 15:67-80. 2009..Modification of lipopolysaccharide by in vivo conditions or by bacterial gene loss has an impact on omptin function. Creation of bacterial surface proteolysis is thus a coordinated function involving several surface structures...
- Temperature-induced changes in the lipopolysaccharide of Yersinia pestis affect plasminogen activation by the pla surface proteaseMarjo Suomalainen
Department of Biosciences, FIN 00014 University of Helsinki, Helsinki, Finland
Infect Immun 78:2644-52. 2010..The temperature-induced changes in LPS are known to help Y. pestis to avoid innate immune responses, and our results strongly suggest that they also potentiate Pla-mediated proteolysis...
- Osteopontin modulates prostate carcinoma invasive capacity through RGD-dependent upregulation of plasminogen activatorsAdriano Angelucci
Department of Experimental Medicine, University of L Aquila, Italy
Biol Chem 383:229-34. 2002..The pattern of protease expression was modified by osteopontin and was characterized by an upregulation of plasminogen activators. Our findings suggest that osteopontin may confer selective malignant potential to prostate cancer cells ..
- Human single-chain urokinase is activated by the omptins PgtE of Salmonella enterica and Pla of Yersinia pestis despite mutations of active site residuesHanna M Järvinen
Division of General Microbiology, Department of Biosciences, University of Helsinki, P O Box 56, FI, 00014, Finland
Mol Microbiol 89:507-17. 2013..Point mutations of active site residues in Pla and PgtE had different effects on the proteolysis of plasminogen and of scuPA, indicating versatility in omptin proteolysis. ..
- Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of Yersinia pestisM Kukkonen
Division of General Microbiology, Department of Biosciences, University of Helsinki, Finland
Mol Microbiol 40:1097-111. 2001..We propose that inactivation of alpha2-antiplasmin by Pla of Y. pestis promotes uncontrolled proteolysis and contributes to the invasive character of plague...
- Bacterial plasminogen activators and receptorsK Lähteenmäki
Division of General Microbiology, Department of Biosciences, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
FEMS Microbiol Rev 25:531-52. 2001..plasmin(ogen) on the bacterial surface, an event that enhances activation of plasminogen by mammalian plasminogen activators. Bacteria also influence secretion of plasminogen activators and their inhibitors from mammalian cells...
- Plasminogen binding and activation at the surface of Helicobacter pylori CCUG 17874M Pantzar
Department of Medical Microbiology, University of Lund, Lund, Sweden
Infect Immun 66:4976-80. 1998....
- Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activatorsSun Ryung Lee
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurosci Lett 417:1-5. 2007b>Plasminogen activators are used in thrombolytic stroke therapy. However, it is increasingly recognized that they have other actions besides fibrinolysis...
- Interaction between group A streptococci and the plasmin(ogen) system promotes virulence in a mouse skin infection modelZ Li
Laboratory of Pathology, Division of Clincal Science, NCI NIH, Bethesda, MD 20895 1500
J Infect Dis 179:907-14. 1999..These results support the hypothesis that acquisition of a surface-associated plasmin(ogen)-dependent enzymatic activity can contribute to the virulence of group A streptococcal invasive infections...
- Differential effects of nonsteroidal antiinflammatory drugs on the IL-1 altered expression of plasminogen activators and plasminogen activator inhibitor-1 by articular chondrocytesT Sadowski
Institute of Pharmacology and Toxicology, University of Bonn, Germany
Inflamm Res 51:427-33. 2002..To determine the in vitro effects of several nonsteroidal antiinflammatory drugs on the IL-1 altered expression and activity of tPA, uPA and PAI-1 by articular chondrocytes...
- Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitorM V Cubellis
Institute of Microbiology, University of Copenhagen, Denmark
Proc Natl Acad Sci U S A 86:4828-32. 1989..The possibility that in adherent cells a different localization of PAI-1 and uPA leads to protection of uPA from PAI-1 is to be considered...
- Fibrin binding and the regulation of plasminogen activators during thrombolytic therapyC Longstaff
Biotherapeutics Division, NIBSC, S Mimms, Herts, EN6 3QG, UK
Cardiovasc Hematol Agents Med Chem 6:212-23. 2008....
- The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infectionJun Sato
W M Keck Center for Transgene Research and the Department of Chemistry, University of Notre Dame, Notre Dame, Indiana, IN 46556, USA
Am J Pathol 163:517-31. 2003..avium from lungs. Thus, plasmin(ogen) functions in limiting progressive fibrosis in the granuloma during a chronic mycobacterial infection...
- Roles of the plasminogen activator streptokinase and the plasminogen-associated M protein in an experimental model for streptococcal impetigoMikael D Svensson
Department of Laboratory Medicine, Lund University, Lund, Sweden
Microbiology 148:3933-45. 2002..An integrated model for superficial infection at the skin is presented...
- Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella entericaMaini Kukkonen
Division of General Microbiology, Department of Biosciences, FIN 00014 University of Helsinki, Helsinki, Finland
Mol Microbiol 51:215-25. 2004..Loss of O-antigen facilitates Pla functions and invasiveness of Y. pestis; on the other hand, smooth LPS renders plasminogen activator cryptic in S. enterica...
- Role of MMPs and plasminogen activators in angiogenesis after transmyocardial laser revascularization in dogsWei Li
Second Department of Surgery, Fukui Medical University, Japan
Am J Physiol Heart Circ Physiol 284:H23-30. 2003..We conclude that TMLR induces the expression of MMPs, TIMPs, and urokinase-type PA and that these proteinases play an important role in angiogenesis after TMLR...
- Serine-proteases as plasminogen activators in terms of fibrinolysisMartin Flemmig
Institute of Pharmacy, Freie Universitat Berlin, Berlin, Germany
J Pharm Pharmacol 64:1025-39. 2012This review should give an overview about the natural human plasminogen activators and their various modified variants as well as similar substances isolated from animals, microorganisms and plants...
- The omptin family of enterobacterial surface proteases/adhesins: from housekeeping in Escherichia coli to systemic spread of Yersinia pestisMaini Kukkonen
General Microbiology, Faculty of Biosciences, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014 Helsinki, Finland
Int J Med Microbiol 294:7-14. 2004....
- Molecular adaptation of a plant-bacterium outer membrane protease towards plague virulence factor PlaJohanna Haiko
Division of General Microbiology, Department of Biosciences, P, O, Box 56, FI 00014 University of Helsinki, Finland
BMC Evol Biol 11:43. 2011..We addressed three virulence-associated functions exhibited by Pla, i.e., proteolytic activation of plasminogen, proteolytic degradation of serine protease inhibitors, and invasion into human cells...
- Genetic analysis of Streptococcus uberis plasminogen activatorsPhilip N Ward
Institute for Animal Health, Compton Laboratory, Compton, Berkshire, RG20 7NN, UK
Indian J Med Res 119:136-40. 2004Streptococci produce a diverse range of secreted plasminogen activators capable of converting mammalian plasminogen to plasmin in a species-specific manner...
- Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensisRoger F Hou
Department of Entomology, National Chung Hsing University, Taichung 402, Taiwan, ROC
Int J Parasitol 34:1355-64. 2004..These results suggest that tissue-type plasminogen activator and urokinase-type plasminogen activator may be play a role in the pathogenesis of eosinophilic meningitis of angiostrongyliasis...
- Binding of human single chain urokinase to Chinese Hamster Ovary cells and cloning of hamster u-PARB Fowler
Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Thromb Haemost 80:148-54. 1998..In addition, the results of our studies suggest that the hamster may be a useful small animal model for studies of human urokinase function...
- Plasminogen activators and their inhibitor gene expression in cutaneous NF1-related neurofibromasVappu Sirén
Haartman Institute, University of Helsinki, P O Box 21, 00014, Helsinki, Finland
Arch Dermatol Res 297:421-4. 2006..We wanted to study plasminogen activators, urokinase (uPA) and tissue type (tPA) and their inhibitor PAI-1, which have not earlier been studied ..
- Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblastsTomoko Katono
Nihon University Graduate School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
Arch Oral Biol 54:146-55. 2009..We examined the effects of nicotine and LPS on the expression of matrix metalloproteinases (MMPs), plasminogen activators (PAs), and their inhibitors, including tissue inhibitors of metalloproteinases (TIMPs) and PA inhibitor-1 (..
- CSF levels of growth factors and plasminogen activators in leptomeningeal metastasesB van de Langerijt
Department of Neurology, Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Neurology 67:114-9. 2006....
- Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestisDeyan Luo
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 190:4149-61. 2013..The data suggest that T cells combat plague in conjunction with neutrophils, which require help from fibrin to withstand Y. pestis encounters and effectively clear bacteria...
- Plasminogen activators and plasminogen activator inhibitors in endometriosisJuan Gilabert-Estelles
Department of Gynecology Human Reproduction, Hospital Universitario La Fe, Valencia, Spain
Front Biosci 10:1162-76. 2005..Proteolytic status is determined by the imbalance between plasminogen activators and plasminogen activator inhibitors, which are expressed differently depending on the type of lesion ..
- Levels of plasminogen activators and their inhibitors in maternal and umbilical cord plasma in severe preeclampsiaEva Maria Roes
Departments of Obstetrics and Gynecology, University Medical Center Nijmegen, Geert Grooteplein 8, 6525 GA Nijmegen, The Netherlands
Am J Obstet Gynecol 187:1019-25. 2002..The purpose of this study was to evaluate the plasminogen activator system in maternal and umbilical cord plasma in patients with severe preeclampsia compared with control subjects with normotensive pregnancies...
- Functional roles of streptokinase C-terminal flexible peptide in active site formation and substrate recognition in plasminogen activationPeng Zhai
Crystallography Research Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, Oklahoma 73104, USA
Biochemistry 42:114-20. 2003..Attempts at using a purified C-tail peptide to rescue the activity loss of the truncation mutants failed, suggesting that the integrity of the SK C-terminal peptide is important for the full function of SK...
- Thrombin-activatable fibrinolysis inhibitor is degraded by Salmonella enterica and Yersinia pestisM Valls Seron
Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Thromb Haemost 8:2232-40. 2010..Thrombin-activatable fibrinolysis inhibitor (TAFI) has anti-fibrinolytic properties as the active enzyme (TAFIa) removes C-terminal lysine residues from fibrin, thereby attenuating accelerated plasmin formation...
- Effects of tetracyclines on the production of matrix metalloproteinases and plasminogen activators as well as of their natural inhibitors, tissue inhibitor of metalloproteinases-1 and plasminogen activator inhibitor-1T Sadowski
Institute of Pharmacology and Toxicology, University of Bonn, Germany
Inflamm Res 50:175-82. 2001..effects on the expression of MMP-1, MMP-3, tissue inhibitor(s) of metalloproteinase-1 (TIMP-1), plasminogen activators (PA), and PA inhibitor-1, which are all involved in the ultimate regulation of MMP activity could provide ..
- Role of plasminogen activators during healing after uterine serosal lesioning in the ratUjjwal Kumar Rout
C S Mott Center for Human Growth and Development, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Fertil Steril 79:138-45. 2003Study the expression pattern of tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activators during uterine serosal healing after lesioning in a rat model.
- The plasmin-antiplasmin system: structural and functional aspectsJohann Schaller
Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, Bern, Switzerland
Cell Mol Life Sci 68:785-801. 2011..The activity of the plasminogen activators is primarily regulated by the plasminogen activator inhibitors 1 and 2, members of the serine protease ..
- Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptinsThomas H Yun
Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, IL 61801, USA
Blood 113:1139-48. 2009..This may contribute to the hemostatic imbalance in disseminated intravascular coagulation and other coagulopathies accompanying severe sepsis...
- Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesisS Brodsky
Department of Medicine, State University of New York, Stony Brook, New York 11794 8152, USA
Am J Physiol Heart Circ Physiol 281:H1784-92. 2001....
- Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegenerationGabriel T Liberatore
Department of Medicine, Monash University, Box Hill Hospital, Victoria, Australia
Stroke 34:537-43. 2003..The purpose of this study was to compare the ability of DSPA and tPA to promote kainate- and N-methyl-D-aspartate (NMDA)-induced neurodegeneration in tPA-/- mice and wild-type mice, respectively...
- Plasminogen activators and their inhibitors in human saliva and salivary gland tissueOskari J Virtanen
Department of Virology, Haartman Institute, University of Helsinki, Finland
Eur J Oral Sci 114:22-6. 2006The purpose of this study was to identify plasminogen activators (PA) and their specific inhibitors in human cell-free saliva and to investigate their expression in salivary gland tissue...
- Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plagueFlorent Sebbane
Laboratory of Zoonotic Pathogens and Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Proc Natl Acad Sci U S A 103:5526-30. 2006..Subsequent acquisition of the plasminogen activator gene by horizontal transfer enabled the bubonic form of disease and increased the potential for epidemic spread...
- Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interactionA Nykjaer
Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus, Denmark
J Cell Biol 141:815-28. 1998..We conclude that a site within CIMPR, distinct from its previously known ligand binding sites, binds uPAR and modulates its subcellular distribution...
- Plasminogen activation by invasive human pathogensM D Boyle
Department of Microbiology, Medical College of Ohio, Toledo 43699 0008, USA
Thromb Haemost 77:1-10. 1997..the interaction between invasive human pathogens expressing plasmin(ogen) receptors and/or producing plasminogen activators with the human plasmin(ogen) system is described...
- The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteasesE Appella
J Biol Chem 262:4437-40. 1987..Thus, residues 20-30 of uPA apparently confer receptor binding specificity, and residues 13-19 provide the proper conformation to the adjacent binding region...
- The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexesA Estreicher
Institute of Histology and Embryology, University of Geneva Medical School, Switzerland
J Cell Biol 111:783-92. 1990....
- Transforming growth factor beta1 in the human endometrium. Cyclic variation, increased expression by estradiol and progesterone, and regulation of plasminogen activators and plasminogen activator inhibitor-1B Casslen
Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden
Biol Reprod 58:1343-50. 1998..TGFbeta may promote capillary growth during endometrial regeneration...
- Neuronal extracellular proteases facilitate cell migration, axonal growth, and pathfindingN W Seeds
Department of Biochemistry and Molecular Genetics, and Neuroscience Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Cell Tissue Res 290:367-70. 1997..We discuss recent findings that suggest that the biological action of these proteases is more complex than originally thought...
- Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traitsJenni Antikainen
General Microbiology, Faculty of Biosciences, University of Helsinki, Helsinki, Finland
FEMS Immunol Med Microbiol 51:526-34. 2007..e., binding of human plasminogen, enhancement of plasminogen activation by human plasminogen activators, as well as binding to immobilized laminin, fibronectin and collagens...
- Bacterial metastasis: the host plasminogen system in bacterial invasionKaarina Lähteenmäki
General Microbiology, Faculty of Biosciences, University of Helsinki, FIN 00014 Helsinki, Finland
Trends Microbiol 13:79-85. 2005..system by degrading circulating plasmin inhibitors and by influencing the expression levels of mammalian plasminogen activators and activation inhibitors...
- Plasminogen receptors: the sine qua non of cell surface plasminogen activationLindsey A Miles
Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Front Biosci 10:1754-62. 2005Localization of plasminogen and plasminogen activators on cell surfaces promotes plasminogen activation and serves to arm cells with the broad spectrum proteolytic activity of plasmin...
- The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectinS Stefansson
Biochemistry Department, J H Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
Nature 383:441-3. 1996..wound healing, migrating cells increase expression of both the vitronectin receptor (VNR) integrins and plasminogen activators. Here we report that vitronectin significantly enhances the migration of smooth muscle cells (SMCs), and ..
- The safety, efficacy, and pharmacoeconomics of low-dose alteplase compared with urokinase for catheter-directed thrombolysis of arterial and venous occlusionsKoji Sugimoto
Division of Cardiovascular Interventional Radiology, Stanford University Medical Center, Stanford, California, USA
J Vasc Surg 37:512-7. 2003....
- Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failureS Heymans
Center for Transgene Technology, Flanders Interuniversity, Leuven, Belgium
Nat Med 5:1135-42. 1999....
- Plasminogen activators and inhibitor type 1 in neoplastic colonic tissue from patients with familial adenomatous polyposisC F Sier
Department of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands
Br J Cancer 71:393-6. 1995The plasminogen activation cascade is involved in carcinogenesis, invasion and metastasis. In this study plasminogen activators and their type 1 inhibitor were evaluated in colonic tissue from 19 patients with familial adenomatous ..
- Substrate specificity and screening of the integral membrane protease PlaAnton Agarkov
Chemical Biology Program, Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0650, USA
Bioorg Med Chem Lett 18:427-31. 2008..Through the use of parallel synthesis and positional scanning, small tripeptides were identified that are viable substrates for the protease...
- Concentration of plasminogen activators and inhibitor in the human endometrium at different phases of the menstrual cycleS C Koh
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital
J Reprod Fertil 96:407-13. 1992..Ovarian hormonal patterns may therefore influence the activity of plasminogen activators especially of t-PA in the endometrium during various phases of the menstrual cycle.
- Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivoA E May
Haemostasis Research Unit, Max Planck Institute, Kerckhoff Klinik, D 61231 Bad Nauheim, Germany
J Exp Med 188:1029-37. 1998..Moreover, uPAR ligation differentially modulates leukocyte adhesion to endothelium and provides novel targets for therapeutic strategies in inflammation-related vascular pathologies...
- Expression of protease nexin-1 and plasminogen activators during follicular growth and the periovulatory period in cattleMingju Cao
Centre de Recherche en Reproduction Animale, CRRA, Faculte de Medecine Veterinaire, Universite de Montreal, C P 5000 St Hyacinthe, Quebec, Canada
Reproduction 131:125-37. 2006Extracellular matrix remodeling occurs during ovarian follicular development, mediated by plasminogen activators (PAs) and PA inhibitors including protease nexin-1 (PN-1)...
- Differences in the implantation rates of rat embryos developed in vivo and in vitro: possible role for plasminogen activatorsEliahu D Aflalo
Department of Life Sciences, Ben Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel
Fertil Steril 81:780-5. 2004To assess the participation of urokinase-type (uPA) and tissue-type (tPA) plasminogen activators in embryo development and implantation.
- Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapyM Schmitt
Frauenklinik und Poliklinik, Technischen Universitat Munchen, Germany
Thromb Haemost 78:285-96. 1997....
- Keeping the blood flowing-plasminogen activator genes and feeding behavior in vampire batsAsa Tellgren-Roth
Department of Molecular Biology, University of Wyoming, Laramie, WY, 82071, USA
Naturwissenschaften 96:39-47. 2009..The evolution of vampire bat plasminogen activators can now be linked phylogenetically to the transition in feeding behavior among vampire bat species from ..
- Effect of ultrasound on enzymatic activity of selected plasminogen activatorsAzita Soltani
Pre Clinical Research Department, EKOS Corporation, 22030 20th Avenue SE, Suite 101, Bothell, WA 98021, USA
Thromb Res 119:223-8. 2007Ultrasound has been shown to accelerate enzymatic fibrinolysis with adjunctive plasminogen activators. Additionally, ultrasound is known for interaction with biological substances on molecular level in sonodynamic therapy and ..
- uPAR: a versatile signalling orchestratorFrancesco Blasi
Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
Nat Rev Mol Cell Biol 3:932-43. 2002....
- Metalloproteinases and plasminogen activators in vessel remodelingAlex Bobik
Cell Biology Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne Victoria 8008, Australia
Curr Hypertens Rep 5:466-72. 2003....
- Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?G Deng
Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
J Cell Biol 134:1563-71. 1996..Finally, we show that uPA can rapidly reverse this effect of PAI-1. Taken together, these results suggest a dynamic regulatory role for PAI-1 and uPA in uPAR-mediated cell adhesion and release...
- Capsular antigen fraction 1 and Pla modulate the susceptibility of Yersinia pestis to pulmonary antimicrobial peptides such as cathelicidinEstela M Galván
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
Infect Immun 76:1456-64. 2008..Taken together, our data indicated that Pla might act as a virulence factor not only by processing plasminogen but also by inactivating CAMPs, particularly when F1 is not expressed...
- Staphylokinase reduces plasmin formation by endogenous plasminogen activatorsTao Jin
Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
Eur J Haematol 81:8-17. 2008..Increased levels of circulating plasminogen (Plg) activators such as tissue- or urokinase-type plasminogen activators (tPA or uPA respectively) are the most common causes of hyperfibrinolysis, occasionally causing major ..
- A plasminogen-activating protease specifically controls the development of primary pneumonic plagueWyndham W Lathem
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
Science 315:509-13. 2007..Inhibition of Pla expression prolonged the survival of animals with the disease, offering a therapeutic option to extend the period during which antibiotics are effective...
- In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captoprilJaime R Merchan
Division of Hematology Oncology, Department of Medicine and the Center for Study of the Tumor Microenvironment, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Natl Cancer Inst 95:388-99. 2003Many antiangiogenic molecules are proteolytically cleaved from larger plasma proteins. For example, plasminogen activators cleave plasminogen into plasmin, and plasmin is converted into angiostatin in the presence of sulfhydryl donors...
- Contribution of plasminogen activators and their inhibitors to the survival prognosis of patients with Dukes' stage B and C colorectal cancerS Ganesh
Department of Gastroenterology and Hepatology, University Hospital Leiden, The Netherlands
Br J Cancer 75:1793-801. 1997....
- Role of plasminogen activator-plasmin system in tumor angiogenesisJ M Rakic
Department of Ophthalmology, CHU, Sart Tilman, 4000 Liege, Belgium
Cell Mol Life Sci 60:463-73. 2003..In this review, the complex mechanisms of action of the serine proteases in pathological angiogenesis are summarized alongside possible therapeutic applications...
- Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysisA L Roldan
University Institute of Microbiology, Copenhagen, Denmark
EMBO J 9:467-74. 1990..The Mr calculated on the basis of the cDNA sequence, approximately 35,000, agrees well with that of the deglycosylated receptor...
- Urokinase and tissue plasminogen activators and their inhibitor PAI-1 in human tumorsE S Gershtein
N N Blokhin Cancer Research Center, Russian Academy of Medical Sciences
Bull Exp Biol Med 131:67-72. 2001The content of urokinase and tissue plasminogen activators and their inhibitor PAI-1 in tumors and histologically intact tissues from patients with breast, ovarian, and non-small-cell lung cancer was measured by enzyme immunoassay...
- The Pla surface protease/adhesin of Yersinia pestis mediates bacterial invasion into human endothelial cellsK Lähteenmäki
Division of General Microbiology, Department of Biosciences, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
FEBS Lett 504:69-72. 2001..coli XL1(pMRK2), which expresses the omptin homolog from E. coli. The results identify Pla as an invasion protein of Y. pestis and show that the invasive function does not involve the proteolytic activity of Pla...
- Plasminogen activators: a comparisonDev B Baruah
Department of Quality Assurance Techniques, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune 411038, India
Vascul Pharmacol 44:1-9. 2006..Now a days several newer plasminogen activators with different pharmacokinetic and pharmacodynamic properties have been developed to treat thrombotic ..
- Overexpression of plasminogen activators in the nucleus accumbens enhances cocaine-, amphetamine- and morphine-induced reward and behavioral sensitizationA Bahi
Institute of Biochemistry, University of Fribourg, Fribourg, Switzerland
Genes Brain Behav 7:244-56. 2008..Taken together, these data add further evidence for a significant function of extracellular proteases tPA and uPA in addiction and suggest a differential role of plasminogen activators in this context.
- Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activityR P Czekay
Department of Cellular and Molecular Medicine, San Diego, La Jolla, California 92093 0651, USA
Mol Biol Cell 12:1467-79. 2001....
- Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemiaDorothe Burggraf
Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
Neurobiol Dis 25:506-13. 2007..Hemoglobin extravasation was also significantly reduced. Our results suggest that doxycycline may have a potential use as an anti-ischemic compound since it provides microvascular protection by inhibiting the plasminogen system...
- Endovascular management of acute extensive iliofemoral deep venous thrombosis caused by May-Thurner syndromeN H Patel
Department of Radiology, Indiana University Medical Center, Indianapolis, USA
J Vasc Interv Radiol 11:1297-302. 2000..The authors report their experience on the treatment of acute extensive iliofemoral deep venous thrombosis (DVT) due to May-Thurner syndrome using endovascular techniques...
- Anti-tumor activity of a combination of plasminogen activator and captopril in a human melanoma xenograft modelRenate R J de Groot-Besseling
Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands
Int J Cancer 112:329-34. 2004..Angiostatin is generated in vitro in a 2-step process. First, plasminogen is converted to plasmin by plasminogen activators. Next, plasmin excises the angiostatin fragment from plasminogen, a process requiring molecules that are ..
- Autonomic, Endothelial, and Inflammatory Correlates of Sleep DurationMERCEDES RENEE CARNETHON; Fiscal Year: 2012..Findings from this study will suggest mechanisms to explain the prior observed associations between sleep duration and CVD risk factors. ..
- Antiphospholipid antibodies and lupus: new molecular targets for treatmentEmilio B Gonzalez; Fiscal Year: 2013..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs. ..
- Metabolic regulation of diabetic nephropathyKaren Block; Fiscal Year: 2013..This work may have major therapeutic implications. ..
- Role of Matrix Metalloproteinase-1 in Endothelial Cell SenescenceCatherine D Mao; Fiscal Year: 2010....
- Regulation of factor VIII Levels and Activity by Members of LDL Receptor FamilyDudley K Strickland; Fiscal Year: 2013..that plays an important role in the catabolism of several ligands including apoE-enriched lipoproteins, plasminogen activators, and serpin-enzyme complexes...
- Inhibition of matrix proteases to sensitize medulloblastoma cells to radiationAndrei L Gartel; Fiscal Year: 2013..The present study explores the usefulness of gene therapy to inhibit protease expression in conjunction with radiation for killing of medulloblastoma cells with lower toxicity. ..
- Inhibitors of the Y. pestis cell surface plasminogen activator for biodefenseMarjorie H Barnes; Fiscal Year: 2010..These new drugs will not be susceptible to existing resistance mechanisms and will provide a proof of principle for the efficacy of this therapeutic approach. ..
- MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic StrokeRobert A Knight; Fiscal Year: 2010..e., BBB opening) and both will be functions of the variations in BBB associated proteins and/or brain swelling;and 2) the size of these changes are correlated over time, ROI, and treatment. ..
- Regulation of Signaling Receptor Activity by LRP-1Steven L Gonias; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: Low density lipoprotein receptor-related protein has emerged as an important regulator of inflammation and atherosclerosis. This proposal seeks to elucidate the responsible mechanisms. ..
- Caveolins in the Pathogenesis of Idiopathic Pulmonary FibrosisDan N Predescu; Fiscal Year: 2010..End of Abstract) ..
- Regulation of Fibronectin Matrix Assembly by uPARPAULA J MC KEOWN-LONGO; Fiscal Year: 2012....
- PlGF-HIF1a-miRNA Axis in Sickle Pulmonary HypertensionPunam Malik; Fiscal Year: 2013..These studies will likely provide new diagnostic bio-markers for assessment of PHT, and novel therapeutic targets for a disease that currently has few or no therapeutic options. ..
- Treatment of stroke with a clinically approved proteasome inhibitorLi Zhang; Fiscal Year: 2012..Therefore, in the current application, we propose to investigate the neuroprotective effects of VELCADE alone and incombination with tPA and the mechanisms underlying the beneficial effects in aged rats after embolic stroke. ..
- Novel therapeutics for vesicants and toxic inhaled chemicals (U54)Carl W White; Fiscal Year: 2013..Agent(s) found effective for CEES/NM would be evaluated in skin injury by SM. These approaches will identify promising rescue agents for skin and lung injury by toxic gases. ..
- Plasminogen activators and NMDA after brain injuryWilliam M Armstead; Fiscal Year: 2012..We propose that plasminogen activators change the MAPK isoform expression/activation profile in an LRP dependent process to elicit both initial ..
- The Role of Vascular Innervation on Tissue-type Plasminogen Activator ReleaseJAMES ANTHONY SHEERIN MULDOWNEY; Fiscal Year: 2013..With the overwhelming prevalence of vascular disease nationally, and worldwide, new insights and strategies have the potential translate to a tremendous public health impact...
- Adjunctive Use of Apyrase to Fibrinolytic TherapyRidong Chen; Fiscal Year: 2013....
- Dichotomous Roles of Thrombin in Acetaminophen HepatotoxicityROBERT ANDREW ROTH; Fiscal Year: 2013..Elucidating mechanisms by which APAP-induced liver injury progresses is essential for defining novel strategies to prevent liver failure in patients and for the general understanding of the pathogenesis of drug-induced liver injury. ..
- S-Nitrosylated Hemoglobin and Ischemic Brain InjuryDavid Warner; Fiscal Year: 2010..We will then examine whether this effect is important in reducing the amount of tissue damage and neurologic impairment caused by the stroke. ..
- Investigation of underlying mechanisms of sex differences in cerebral ischemiaChad S Siegel; Fiscal Year: 2010..The overall goal of this proposal is to investigate mechanisms underlying sex differences in ischemic cell death. ..
- Renin-angiotensin and fibrinolysis interaction in humansNANCY JOAN BROWN; Fiscal Year: 2013....
- Inflammation and Injury in Obesity Hypertension in African American AdolescentsBonita Falkner; Fiscal Year: 2010..abstract_text> ..
- Cell Surface Plasminogen Activation and HypertensionRobert J Parmer; Fiscal Year: 2013....
- Vitamin D deficiency and treatment in male veterans at risk for diabetesElena Barengolts; Fiscal Year: 2013....
- Plasminogen activator inhibitor-1 in tumor progression and metastasisYves A DeClerck; Fiscal Year: 2013..inhibitors (serpins) that controls the activation of plasminogen into plasmin by tissue and urokinase type plasminogen activators (tPA and uPA, respectively). In the past, PAI-1 was considered to be anti-tumorigenic...
- Role for tissue-type plasminogen activator in suppression of hepatic fibrosisLiang I Kang; Fiscal Year: 2013..Since t-PA is already FDA-approved for clinical use, the impact of this project is tremendous in terms of potential expedited development of therapies for liver cirrhosis patients who currently have limited treatment options. ..
- Targeted Therapy of Triple Negative Breast Cancer Using Theranostic NanoparticlesLily Yang; Fiscal Year: 2013..Clinical impact: The proposed study addresses the urgent need in clinical management of TNBC to improve the survival of patients afflicted with TNBC. ..
- PAI-1 and Vitronectin in Failure of Coronary RevascularizationWilliam P Fay; Fiscal Year: 2013..applicant): Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue- and urinary-type plasminogen activators. Vitronectin (VN) is an adhesive glycoprotein present in extracellular matrix (ECM) and plasma that ..
- Interactions between CNS-specific human kallikreins and the PA system in inflammaMichael Blaber; Fiscal Year: 2009..The goals of the proposal are to understand how such proteases are controlled and how this control can be manipulated to potentially treat diseases of the central nervous system. ..
- MATRIX MEDIATORS OF WOUND HEALINGPaul J Higgins; Fiscal Year: 2010..Our continued clarification of mechanistic controls on PAI-1 gene expression may lead to new targeted therapies for diseases in which excessive or non-resolving angiogenesis is a major pathogenic feature. ..
- Role of Fibrinolytic System in Vein Graft RemodelingWilliam P Fay; Fiscal Year: 2013..We anticipate that the information gained from our experiments will lead to new strategies to treat and prevent vein graft disease. ..
- Endogenous and exogenous protection of the BBB in strokeRichard F Keep; Fiscal Year: 2013..This proposal examines natural defense mechanisms that may protect the blood-brain barrier, how to activate those mechanisms or prevent their inactivation therapeutically. ..
- Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2Cheng Jun Hu; Fiscal Year: 2012..Thus, HIF is good for tumor growth, but bad for our human being. Thus our research on controlling HIF activity has broad impact for all solid tumors. ..
- Technology to improve the assessment of tissue-associated protein biomarkersJEFFREY THOMAS MASON; Fiscal Year: 2013..It will also facilitate the detection and prognostic assessment of breast tumors at earlier stages where clinical options are greatest and where treatment outcomes are most likely to be favorable. ..
- Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for StrokeIrina Y Sazonova; Fiscal Year: 2012..In this project we propose a novel thrombolytic agent and plan to determine its efficacy for the treatment in an experimental model of thromboembolic cerebral ischemia. ..
- KLF2 as a regulator of endothelial cell biologyMUKESH KUMAR JAIN; Fiscal Year: 2012..abstract_text> ..
- Countermeasures for chlorine-induced airway fibrosisGary W Hoyle; Fiscal Year: 2013..This type of research is important because of concerns that U.S. civilians could be adversely affected by the accidental or intentional release of highly toxic chemicals such as chlorine. ..
- Regulation of Pal-1 in Atherosclerosis and ThrombosisYolanda M Fortenberry; Fiscal Year: 2013..This is particularly important, since to date, there are no PAI-1 inhibitors available for clinical use (End of Abstract) ..
- Ah Receptor Anatomy: Implications for Dioxin ToxicityCORNELIS JOHAN ELFERINK; Fiscal Year: 2011..Parallels between humans and mice in the re- generative response, instills confidence that findings generated during these studies will be directly applicable to the human condition. ..
- Matrix Metalloproteinase Inhibitors in StrokeGARY ALLEN ROSENBERG; Fiscal Year: 2010..The overall goal is to identify lead compounds that are patentable and can be used to obtain IND approval. Promising compounds would be useful for U01- funded clinical trials. ..
- Ac-SDKP for Treatment of Acute StrokeZheng Gang Zhang; Fiscal Year: 2013..These studies could potentially provide a new therapy to minimize the adverse effect of tPA on ischemic neurovascular damage, leading to improved neurological outcomes after acute stroke. ..
- Pathogenesis of LymphangioleiomyomatosisLucia Schuger; Fiscal Year: 2010..We believe that the new knowledge obtained from these studies will help to better understand the pathogenesis of LAM and to devise novel therapeutic strategies to treat this disease. ..
- Interactions of Lipoproteins and Cells in Diabetes MellitusRICHARD LOUIS KLEIN; Fiscal Year: 2013..Collectively, these studies will elucidate for the first time the patterns of S1P metabolism in lipoproteins and in diabetes, and define the cellular and plasma mechanisms which mediate this metabolism. ..
- QD-BRET nanosensors for protease detection and imagingJianghong Rao; Fiscal Year: 2012..A sophisticated understanding of the differences of enzyme activity between tumor and normal tissues in living subjects will advance our understanding of cancer metastasis and help develop antimetastasis therapy. ..
- Transcranial Sonothrombolysis with Diagnostic UltrasoundThilo Hoelscher; Fiscal Year: 2013..Noninvasive 'Image-Guided Sonothrombolysis'at the bedside or even in the ambulance vehicle would be a major achievement in stroke therapy. ..
- Treatment and Risk Factor Determinants of Cardiovascular Outcomes in BARI 2DMaria Mori Brooks; Fiscal Year: 2013..Such results would have important clinical implications for the treatment of the large and growing population of patients with type 2 diabetes and stable ischemic heart disease. ..
- Corneal Expression and Function of Slurp1SHIVALINGAPPA KOTTUR SWAMYNATHAN; Fiscal Year: 2013..The anticipated outcomes will define a novel target for therapeutic intervention in managing inflammatory disorders of the ocular surface. ..
- Deleted in liver cancer 1 (DLC1) in liver development and diseaseYi Ping Shih; Fiscal Year: 2013..An understanding of the functional impact of DLC1 in liver development and disease progression will help find new early diagnosis or therapeutic targets for liver disease. ..
- Real-time imaging of tPA fluorescent hybrids in hippocampal neuronsJanis E Lochner; Fiscal Year: 2011..tPA-mediated extracellular proteolysis is also implicated in excitotoxic cell death and the neuronal degeneration associated with Alzheimer<s disease. ..
- Role of Hyperglycemia in Intracerebral HemorrhageEdward P Feener; Fiscal Year: 2013..This grant will examine the hypothesis that the direct effects of plasma kallikrein on hemostasis and peri-hematomal edema contribute to the poor ICH outcomes in diabetes and hyperglycemia. ..
- Urokinase plasminogen activator receptor associated protein and acute lung injuryMichael Bundesmann; Fiscal Year: 2010..It will help us understand how the lung coordinates several components of the repair process. ..
- Protease Pathways in the Gastrointestinal TractToni M Antalis; Fiscal Year: 2010..abstract_text> ..
- Weibel-Palade Bodies: roles in thrombosis, inflammation and strokeDenisa D Wagner; Fiscal Year: 2013..We will investigate how inhibition of a particular component of these vesicles could improve outcome in these major diseases. ..
- Role of the Plasminogen Activator Protease during Pneumonic PlagueWyndham W Lathem; Fiscal Year: 2013..This project is designed to elucidate those mechanisms at a genetic and biochemical level, and may have implications for understanding how other bacterial pathogens affect thrombosis and fibrinolysis during infection as well. ..
- BMP Regulation of TGF-b2 in the Trabecular MeshworkRobert J Wordinger; Fiscal Year: 2012..This study is relevant because it will examine the role of local growth factors in the control of eye pressure and may lead to new treatments for glaucoma. ..
- Vascular protection by epoxide hydrolase inhibition in cerebral ischemiaAlexis N Simpkins; Fiscal Year: 2010..We will also determine if SEH inhibition can decrease fibrosis by using histology and zymography. Elucidating the mechanism of SEH inhibition will aid in determining its potential therapeutic use in high risk patients. ..
- Ah receptor transcriptional regulation through a novel DNA binding siteSHELLY RENEE WILSON; Fiscal Year: 2012..abstract_text> ..
- Preclinical Development of a Novel Plaque-Regressing Therapy For AtherosclerosisMichael W Fanger; Fiscal Year: 2012..Success would ultimately provide a profound medical advancement in treatment of atherosclerosis, a significant benefit to human health, and a dramatic reduction in the economic impact of the number one killer in America. ..
- Novel Methods for Dissolving Blood ClotsGUY LELAND REED; Fiscal Year: 2013..Upon completion of this Phase II project and transfer of commercialization responsibilities to our strategic partner, TSI will investigate the potential benefits of this platform technology to heart and stroke victims. ..
- US-China Collaborative Research on Stroke ImagingJinyuan Zhou; Fiscal Year: 2013..If the hypotheses are proven correct, we expect to have an additional marker that can be used for diagnosis and prognosis of stroke patients in the clinic. ..
- CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSISEDWARD FRANKLIN PLOW; Fiscal Year: 2013..Taken together, these studies will define how plasminogen and its receptors function in biologically important responses. ..
- NEW FUNCTION SERPIN PAI 2 AS A REGULAR OF RBToni Antalis; Fiscal Year: 2009..At the completion of these aims, we anticipate having established the molecular basis for PAI-2 mediated cytoprotection and its importance to inflammation and innate immunity ..
- Suppression of glioma invasion by a bicistronic constuctJASTI RAO; Fiscal Year: 2007..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
- VON WILLEBRAND FACTOR, FIBRINOLYSIS, & THE ENDOTHELIUMKaren Hamilton; Fiscal Year: 1991....
- HEMOSTATIC EFFECTS OF FIBRINOLYTIC THERAPYBARBARA ALEVRIADOU; Fiscal Year: 2000....
- PA/PLASMIN/GELATINASE CASCADE IN DIABETIC NEPHROPATHYWILLIAM BARICOS; Fiscal Year: 2000....
- tPA Neurotoxicity in Hypoxic-Ischemia EncephalopathyChia Yi Kuan; Fiscal Year: 2009..results indicated that ischemia-hypoxia produces a rapid induction of tissue-type and urokinase-type plasminogen activators (tPA and uPA) that coincides with transient thrombosis...
- PLATELETS, PLATELET AGGREGATES & PLASMINOGEN ACTIVATIONJoseph Loscalzo; Fiscal Year: 1991..From these studies, we hope to gain insight into mechanisms by which vessel wall products facilitate dissolution of the platelet thrombi that are implicated in the pathogenesis of many vascular disorders...
- ENVIRONMENTAL MODULATION OF FIBRINOLYSIS INHIBITORSSTEVEN GONIAS; Fiscal Year: 1992..The major goal of this research program is to study the regulation of plasmin and plasminogen activators in experimental systems that model important "non-plasma" sites of fibrinolytic activity...
- A THECAL ROLE IN OVULATIONKATHERINE ROBY; Fiscal Year: 1999..The studies outlined in this proposal begin to assess the mechanism whereby TCDD blocks ovulation. ..
- PRESERVATION AND CARDIAC TRANSPLANT VASCULOPATHYDavid Pinsky; Fiscal Year: 2003..These experiments will provide new insights into mechanisms by which early ischemic injury leads to early graft failure and TCAD, and proffer new strategies for prevention. ..