kallikreins

Summary

Summary: Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).

Top Publications

  1. pmc Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 286:687-706. 2011
  2. ncbi Epidermal barrier dysfunction in atopic dermatitis
    Michael J Cork
    The Paediatric Dermatology Clinic, Sheffield Children s Hospital, Sheffield, UK
    J Invest Dermatol 129:1892-908. 2009
  3. ncbi The emerging roles of serine protease cascades in the epidermis
    Petra Ovaere
    Department of Biomedical Molecular Biology, Ghent University, Belgium
    Trends Biochem Sci 34:453-63. 2009
  4. ncbi Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus
    Mitchell G Lawrence
    Australian Prostate Cancer Research Centre Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Endocr Rev 31:407-46. 2010
  5. ncbi Human kallikrein 6 as a biomarker of alzheimer's disease
    E P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Clin Biochem 33:663-7. 2000
  6. ncbi Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
    Cecile Caubet
    UMR5165 Epidermis Differentiation and Rheumatoid Autoimmunity, CNRS P Sabatier University Institut Fédératif de Recherche 30 and INSERM CNRS Université P Sabatier Centre Hospitalier Universitaire, Toulouse, France
    J Invest Dermatol 122:1235-44. 2004
  7. pmc A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33
    Hemang Parikh
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20877, USA
    Hum Genet 127:91-9. 2010
  8. ncbi Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer
    Jong Tae Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
    Cancer 117:2608-19. 2011
  9. ncbi Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
    Yasuo Shinoda
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 98:1078-86. 2007
  10. ncbi Mechanisms of disease: the tissue kallikrein-kinin system in hypertension and vascular remodeling
    Paolo Madeddu
    Experimental Cardiovascular Medicine, Bristol Heart Institute, Bristol University, Bristol, UK
    Nat Clin Pract Nephrol 3:208-21. 2007

Detail Information

Publications292 found, 100 shown here

  1. pmc Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 286:687-706. 2011
    ..The implications of KLK8 elevation and hyperactivity in desquamatory and inflammatory skin disease conditions remain to be studied...
  2. ncbi Epidermal barrier dysfunction in atopic dermatitis
    Michael J Cork
    The Paediatric Dermatology Clinic, Sheffield Children s Hospital, Sheffield, UK
    J Invest Dermatol 129:1892-908. 2009
    ..Our understanding of gene-environment interactions should lead to a better use of some topical products, avoidance of others, and the increased use and development of products that can repair the skin barrier...
  3. ncbi The emerging roles of serine protease cascades in the epidermis
    Petra Ovaere
    Department of Biomedical Molecular Biology, Ghent University, Belgium
    Trends Biochem Sci 34:453-63. 2009
    ..b>Kallikreins can form a signaling cascade to coordinate corneocyte desquamation...
  4. ncbi Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus
    Mitchell G Lawrence
    Australian Prostate Cancer Research Centre Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Endocr Rev 31:407-46. 2010
    ..A more comprehensive understanding of the transcriptional regulation of kallikreins may help the field make more informed hypotheses about the physiological functions of kallikreins and their ..
  5. ncbi Human kallikrein 6 as a biomarker of alzheimer's disease
    E P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Clin Biochem 33:663-7. 2000
    ..Our aim was to examine the possible use of cerebrospinal fluid, blood and tissue, and human kallikrein 6 (hK6) concentration as a marker of AD...
  6. ncbi Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
    Cecile Caubet
    UMR5165 Epidermis Differentiation and Rheumatoid Autoimmunity, CNRS P Sabatier University Institut Fédératif de Recherche 30 and INSERM CNRS Université P Sabatier Centre Hospitalier Universitaire, Toulouse, France
    J Invest Dermatol 122:1235-44. 2004
    ..These results strongly suggest that the two kalikreins are involved in desquamation. A model is proposed for desquamation that could be regulated by a precisely controlled protease-protease inhibitor balance...
  7. pmc A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33
    Hemang Parikh
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20877, USA
    Hum Genet 127:91-9. 2010
    ....
  8. ncbi Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer
    Jong Tae Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
    Cancer 117:2608-19. 2011
    ..In the current study, overexpression of KLK6 was identified in colon cancer, and the possibility that KLK6 may be a suitable candidate as a tumor marker was examined...
  9. ncbi Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
    Yasuo Shinoda
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 98:1078-86. 2007
    ..0790 and P = 0.0037, respectively). These observations indicate that KLK5, -6, -8 and -9 may be the most likely targets of the 19q13.3 amplification, and may play a crucial role in promoting cancer-cell invasion in bladder tumor...
  10. ncbi Mechanisms of disease: the tissue kallikrein-kinin system in hypertension and vascular remodeling
    Paolo Madeddu
    Experimental Cardiovascular Medicine, Bristol Heart Institute, Bristol University, Bristol, UK
    Nat Clin Pract Nephrol 3:208-21. 2007
    ....
  11. ncbi Kallikrein 4 is associated with paclitaxel resistance in ovarian cancer
    Zhijun Xi
    Department of Biology, University of Oslo, Oslo, Norway
    Gynecol Oncol 94:80-5. 2004
    ..The goal of this study was to investigate if KLK4 protein (hK4) is expressed in ovarian carcinoma lesions and if it is associated with paclitaxel resistance...
  12. ncbi Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain
    K Yamashiro
    Suntory Institute for Biomedical Research, Osaka, Japan
    Biochim Biophys Acta 1350:11-4. 1997
    ..Successful production of the active neurosin was shown after treating the supernatant of the culture of the transfectants with enterokinase...
  13. ncbi Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients
    C V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Clin Cancer Res 7:2380-6. 2001
    ..CONCLUSIONS: Our findings indicate that KLK4 expression is associated with more aggressive forms of ovarian cancer...
  14. pmc Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model
    David Pépin
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 6:e26075. 2011
    Human tissue kallikreins (KLKs) are members of a multigene family of serine proteases aberrantly expressed in many cancer types...
  15. ncbi Impact of expression differences of kallikrein-related peptidases and of uPA and PAI-1 between primary tumor and omentum metastasis in advanced ovarian cancer
    J Dorn
    Department of Obstetrics and Gynecology, Technische Universitaet Muenchen, Munich, Germany
    Ann Oncol 22:877-83. 2011
    ..The changes in levels of these factors from primary tumor to omentum metastasis ('level differentials') could thus be associated with metastastic processes...
  16. ncbi Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression
    Andrew J Ramsay
    Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Corner Musk Ave and Blamey St, Kelvin Grove, Queensland 4059, Australia
    J Biol Chem 283:12293-304. 2008
    ..These data provide insight into KLK4-mediated cell signaling and suggest that signals induced by this enzyme via PARs may be important in prostate cancer...
  17. ncbi Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers
    Michael Sidiropoulos
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 26:324-36. 2005
    ..Recently, it has been shown that CpG island hypermethylation of the KLK10 gene is responsible for the tumor-specific loss of KLK10 gene expression in certain breast cancer cell lines...
  18. pmc The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer
    M Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Hospital, Athens, Greece
    Br J Cancer 100:1659-65. 2009
    ..86 beyond the clinical factors at year 1, showing that it can increase the accuracy of prediction of overall survival beyond the traditional clinical information, particularly the short-term (1 year) survival after surgery...
  19. pmc Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript
    Z Kote-Jarai
    The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Hum Genet 129:687-94. 2011
    ..Using molecular dynamic simulation, we showed evidence that this variant has the potential to introduce alterations in the protein or affect RNA splicing. We propose that rs17632542 may directly influence PrCa risk...
  20. pmc Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome
    Katiuchia Uzzun Sales
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Nat Genet 42:676-83. 2010
    ..These results uncover a pathogenic matriptase-pro-kallikrein pathway that could operate in several human skin and inflammatory diseases...
  21. pmc Three dysregulated miRNAs control kallikrein 10 expression and cell proliferation in ovarian cancer
    N M A White
    Department of Laboratory Medicine, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
    Br J Cancer 102:1244-53. 2010
    ..The control of kallikrein genes and their physiological function in cancer is not well understood. We hypothesized that microRNAs (miRNAs) represent a novel mechanism for post-transcriptional control of KLK expression in cancer...
  22. ncbi The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer
    Stephen C L Koh
    Department of Obstetrics and Gynaecology, National University Health Systems NUHS, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
    Arch Gynecol Obstet 284:183-90. 2011
    To assess known cancer biomarkers CA-125, human tissue kallikreins KLK6 and KLK10, hemostatic markers and age with 5-year survival outcome from epithelial ovarian cancer.
  23. pmc Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells
    Rebecca S Henkhaus
    Cancer Biology Interdisciplinary Program, Arizona Cancer Center, The University of Arizona, 1515 N Campbell Ave, Tucson, AZ 85724, USA
    Biol Chem 389:757-64. 2008
    ..These data support the oncogenic role of KLK6 in colorectal cancer...
  24. ncbi Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
    Anke Ohler
    Institute of Zoology, Cell and Matrix Biology, Johannes Gutenberg University, Mainz, Germany
    Biol Chem 391:455-60. 2010
    ..In summary, we demonstrate a specific interaction between meprin metalloproteases and kallikrein-related peptidases, revealing possible interactions within the proteolytic web...
  25. pmc Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation
    Coen Maas
    Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Invest 118:3208-18. 2008
    ..These results show that the kallikrein-kinin system can be activated by Factor XII, in a process separate from the coagulation cascade, and point to a protective role for Factor XII following activation by misfolded protein aggregates...
  26. ncbi Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
    Mekdes Debela
    Max Planck Institut fur Biochemie, Proteinase Research Group, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Biol Chem 389:623-32. 2008
    ..Interestingly, for KLK4, 5, and 7 extended charged surface regions were observed that most likely serve as exosites for physiological substrates...
  27. pmc Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice
    James P Simmer
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 284:19110-21. 2009
    ..Instead, individual crystallites seemed to spill out of the enamel when fractured. These results demonstrate that Klk4 is essential for the removal of enamel proteins and the proper maturation of enamel crystals...
  28. ncbi The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation
    Christoph Becker-Pauly
    Institute of Zoology, Johannes Gutenberg University, Johannes von Müller Weg 6, Mainz, Germany
    J Invest Dermatol 127:1115-25. 2007
    ....
  29. ncbi The kallikrein-kinin system: current and future pharmacological targets
    Marie Eve Moreau
    Faculty of Pharmacy, University of Montreal, Canada
    J Pharmacol Sci 99:6-38. 2005
    ..This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins. The pharmacologically active kinins, which are often considered as either proinflammatory or cardioprotective, ..
  30. ncbi Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer
    Jin Ju Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak ro, Yuseong Gu, Daejeon 305 806, Republic of Korea
    Tumour Biol 33:731-8. 2012
    ..This study shows that KLK6 is significantly upregulated and secreted in gastric cancer tissues and sera, suggesting that KLK6 might be used as a potential biomarker and therapeutic target for gastric cancer...
  31. ncbi Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs)
    Andrew J Ramsay
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 6 Musk Avenue, Kelvin Grove, Queensland 4059, Australia
    Biol Chem 389:653-68. 2008
    ....
  32. ncbi Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions
    Y Wang
    Institut fur Neurobiochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Cell Mol Life Sci 65:237-52. 2008
    ..Therefore, understanding the interaction among brain trypsin, serpins and PARs will provide invaluable tools for regulating normal brain functions and for the clinical treatment of neural disorders...
  33. ncbi Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients
    Lina Seiz
    Klinische Forschergruppe der Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany
    Biol Chem 393:391-401. 2012
    ..low KLK6 expression; hazard ratio (HR), 1.92; p=0.017; HR, 1.80; p=0.042, respectively]. These results indicate that KLK6 expressed by stromal cells may considerably contribute to the aggressiveness of ovarian cancer...
  34. ncbi Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle
    J D Hooper
    Centre for Molecular Biotechnology, Queensland University of Technology, Brisbane, Queensland, 4001, Australia
    Genomics 73:117-22. 2001
    The kallikreins are a subfamily of serine proteases encoded in human, mouse, and rat by highly conserved tightly clustered multigene families...
  35. ncbi Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem)
    T B Rosatelli
    Dermatology, Department of Medicine, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049 900, Ribeirao Preto, SP, Brazil
    Br J Dermatol 152:650-7. 2005
    ..Pemphigus foliaceus (PF) is an autoimmune blistering disease of unknown aetiology, which is endemic in Brazil. Although the pathogenesis of PF is still unknown, proteins of the contact system have been implicated...
  36. ncbi Kallikreins, kininogens and kinin receptors on circulating and synovial fluid neutrophils: role in kinin generation in rheumatoid arthritis
    Bilkish Cassim
    Department of Geriatrics, Nelson Mandela School of Medicine, University of Natal, Durban, South Africa
    Rheumatology (Oxford) 48:490-6. 2009
    ..The aim of this study was to assess the expression of kallikreins, kininogens and kinin receptors in circulating and SF neutrophils, as well as synovial tissue of RA patients, ..
  37. ncbi Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 280:14628-35. 2005
    ..Our findings suggest that hK5 may be implicated in tumor progression, particularly in invasion and angiogenesis, and may represent a novel therapeutic target...
  38. pmc Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes
    Jun Ichi Sakabe
    Department of Dermatology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu 431 3192, Japan
    J Biol Chem 288:17179-89. 2013
    ..KLK5 knockdown in normal cultured human epidermal keratinocytes resulted in higher levels of profilaggrin, indicating that KLK5 potentially functions in profilaggrin cleavage...
  39. ncbi Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?
    Olivia L Tan
    Hormone Dependent Cancer Research Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4001, QLD, Australia
    Biol Chem 387:697-705. 2006
    ..The possible function(s) of the variant transcripts/protein isoforms and potential roles that they may play in hormone-related cancers are still unknown and are the focus of this short review...
  40. ncbi Human kallikrein 4: quantitative study in tissues and evidence for its secretion into biological fluids
    Christina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Chem 51:1432-42. 2005
    ....
  41. ncbi Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications
    E P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Clin Biochem 33:369-75. 2000
    ..One new member is the KLK6 gene, encoding for human kallikrein 6 (hK6), which is also known as zyme/protease M/neurosin. In this paper, we describe development of antibodies and a sensitive immunofluorometric procedure for hK6 protein...
  42. ncbi Human plasma kallikrein-kinin system: physiological and biochemical parameters
    J W Bryant
    University of Mississippi, University, MS 38677 1848, USA
    Cardiovasc Hematol Agents Med Chem 7:234-50. 2009
    ..Genetic models of kallikrein deficiency are needed to evaluate the quantitative role of kallikrein and to validate whether strategies designed to activate or inhibit kallikrein may be important for regulating whole-body BK sensitivity...
  43. pmc Kallikrein gene downregulation in breast cancer
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Br J Cancer 90:167-72. 2004
    ..Probing eight normal and 24 breast cancer SAGE libraries with gene-specific tags for each of the above kallikreins indicated moderate-to-high expression densities in normal breast (27-319 tags per million; tpm, in two to five ..
  44. ncbi Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
    Panagiotis Prezas
    Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich, D 81675 Munich, Germany, and G Papanicolaou Research Center of Oncology, Saint Savas Hospital, GR 11522 Athens, Greece
    Biol Chem 387:807-11. 2006
    ..Accumulating evidence suggests that certain tissue kallikreins are part of an enzymatic cascade pathway that is activated in ovarian cancer and other malignant diseases...
  45. ncbi Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer
    Constantina Petraki
    Department of Pathology, Metropolitan Hospital, Athens, Greece
    Pathol Res Pract 208:104-8. 2012
    ..041). Kaplan-Meier survival curves showed that KLK6-positive patients have statistically significant lower disease-free and overall survival. In conclusion, KLK6 immunostaining is an independent prognostic marker in patients with CRC...
  46. ncbi In-silico analysis of kallikrein gene expression in pancreatic and colon cancers
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Anticancer Res 24:43-51. 2004
    Human kallikreins are a cluster of 15 serine protease genes located in the chromosomal band 19q13.4, a non-randomly rearranged region in many solid tumors, including pancreatic cancer...
  47. ncbi Prognostic impact of CD68 and kallikrein 6 in human glioma
    Tadej Strojnik
    Department of Neurosurgery, University Clinical Centre Maribor, Ljubljanska 5, SI 2000 Maribor, Slovenia
    Anticancer Res 29:3269-79. 2009
    ..To evaluate the expression of CD68 and kallikrein 6 in human gliomas, and investigate their prognostic significance for survival of brain cancer patients in comparison to some known prognostic markers...
  48. ncbi Dysregulation of kallikrein-related peptidases in renal cell carcinoma: potential targets of miRNAs
    Nicole M White
    Department of Laboratory Medicine and the Keenan Research Center in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Biol Chem 391:411-23. 2010
    ..The observation that KLKs could represent targets for miRNAs suggests a post-transcriptional regulatory mechanism with possible future therapeutic applications...
  49. ncbi Extracellular neurosin degrades α-synuclein in cultured cells
    Harutsugu Tatebe
    Department of Neurology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Neurosci Res 67:341-6. 2010
    ..These findings suggest that neurosin targets the extracellular alpha-synuclein...
  50. ncbi Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseases
    Ulf Meyer-Hoffert
    Department of Dermatology, University Hospital Schleswig Holstein, D 24105, Kiel, Germany
    Arch Immunol Ther Exp (Warsz) 57:345-54. 2009
    ..Endogenous and exogenous proteases such as kallikreins, matriptase, caspases, cathepsins, and proteases derived from microorganisms are important in the desquamation ..
  51. pmc KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma
    N M A White
    Division of Biomedical Sciences, Memorial University, St John s, Newfoundland, Canada
    Br J Cancer 101:1107-13. 2009
    ....
  52. ncbi Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response
    Elisabetta Bandiera
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laboratorio di Medicina Molecolare Angelo Nocivelli, University of Brescia, Piazzale Spedali Civili 1, Brescia, Italy
    Int J Gynecol Cancer 19:1015-21. 2009
    ..At the moment, the presence of KLK5 in other ovarian pathological lesions is not clearly determined. Moreover, the possibility of a spontaneous humoral immune response to KLK5 has not been studied yet...
  53. ncbi Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 24:299-309. 2003
    ..297; p < 0.001). Our findings provide evidence for an association between hK5 and more aggressive forms of epithelial ovarian cancer...
  54. pmc Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
    Jason R Pettus
    Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Histol Histopathol 24:197-207. 2009
    ..Control experiments show lack of reactivity against KLK3 (prostate specific antigen). These results demonstrate that kallikreins 5, 7, 8, and 10 are abundantly expressed in human OSCC and may be implicated in malignant progression.
  55. ncbi Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival
    J Dorn
    Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
    Ann Oncol 22:1783-90. 2011
    ..Kallikrein-related peptidases, including KLK5, have been reported to play an important role in the course of the disease...
  56. pmc Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines
    Alexander G Vandell
    Molecular Neuroscience Program, Mayo Medical and Graduate School, Rochester, Minnesota 55905, USA
    J Neurochem 107:855-70. 2008
    ..In this study, we test the hypothesis that kallikreins (KLKs) represent an important pool of endogenous activators of CNS PARs...
  57. ncbi Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival
    Jyotsna Batra
    School of Life Sciences, Hormone Dependent Cancer Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia
    Int J Gynecol Cancer 20:529-36. 2010
    ..We aimed to identify whether KLK10 overexpression could be attributed to genetic variants, in particular, in hormone response elements or transcription factor binding sites...
  58. ncbi The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    J Clements
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Biol Chem 382:5-14. 2001
    The tissue kallikreins are serine proteases encoded by highly conserved multi-gene families. The rodent kallikrein (KLK) families are particularly large, consisting of 13-26 genes clustered in one chromosomal locus...
  59. pmc Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer
    Robert J Klein
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 3:611-9. 2010
    ..874 versus 0.866), providing proof in principle to clinical application for our findings...
  60. ncbi Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 281:12743-50. 2006
    Human tissue kallikreins (hKs) are a family of fifteen serine proteases. Several lines of evidence suggest that hKs participate in proteolytic cascade pathways...
  61. ncbi Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, 15701 Athens, Greece
    Thromb Haemost 101:373-80. 2009
    Several of the novel kallikrein-related peptidases (tissue kallikreins; KLKs) are emerging new serum and/or tissue biomarkers for prostate cancer (CaP) diagnosis, prognosis and monitoring...
  62. ncbi Increased stratum corneum serine protease activity in acute eczematous atopic skin
    R Voegeli
    DSM Nutritional Products Ltd, Branch Pentapharm, Basel CH 4002, Switzerland
    Br J Dermatol 161:70-7. 2009
    ..The breakdown of epidermal barrier function in AD is associated with changes in corneocyte size and maturation, desquamation, lipid profiles, and some protease activities...
  63. ncbi Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma
    Kusumam Joseph
    Department of Medicine, Division of Rheumatology and Clinical Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Allergy Asthma Immunol 101:279-86. 2008
    ..Factor XII-dependent bradykinin formation is thought to be responsible for the swelling associated with the various forms of C1 inhibitor deficiency, and complement activation is augmented during attacks of swelling...
  64. ncbi Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors
    Angeliki Magklara
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada M5G 1X5
    Biochem Biophys Res Commun 307:948-55. 2003
    ..Inhibition of hK6 was achieved via binding to different serpins, among which antithrombin III was the most efficient...
  65. ncbi Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer
    Hisashi Nagahara
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Tsurumihara, Beppu, Japan
    Clin Cancer Res 11:6800-6. 2005
    ..Herein, we investigated the clinicopathologic and biological significance of KLK6 gene expression in human gastric cancer...
  66. ncbi High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis
    Heuzé Vourc h Nathalie
    INSERM, Universite Francois Rabelais de Tours, Tours, France
    J Cell Mol Med 13:4014-22. 2009
    ..We conclude that a high concentration of KLK6 is an indicator of tumour proliferation and an independent predictive factor in NSCLC...
  67. ncbi Interdependence of kallikrein-related peptidases in proteolytic networks
    Nathalie Beaufort
    Department of Obstetrics and Gynecology, Technical University of Munich, Germany
    Biol Chem 391:581-7. 2010
    ..Our observations provide new insights into the regulation of these important tumor-associated proteases...
  68. ncbi Applicability of biomarkers in the early diagnosis of prostate cancer
    Daphne Hessels
    Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Expert Rev Mol Diagn 4:513-26. 2004
    ..This could subsequently lead to a reduction of the number of unnecessary biopsies...
  69. ncbi Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)
    Nathalie Beaufort
    Unité de Défense Innée et Inflammation INSERM E0336, Département de Médecine Moléculaire, Institut Pasteur, F 75015 Paris, France
    Biol Chem 387:217-22. 2006
    ..hK4 may thus modulate the tumor-associated uPA/uPAR-system activity by either activating the pro-enzyme form of uPA or cleaving the cell surface-associated uPA receptor...
  70. ncbi Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers
    Ying Dong
    The Center of Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Clin Cancer Res 9:1710-20. 2003
    ..The purpose of this study was to reexamine the expression of KLK5/hK5 and KLK7/hK7 and their association and to determine whether cancer-related variant transcripts were expressed...
  71. pmc A novel protease homolog differentially expressed in breast and ovarian cancer
    A Anisowicz
    Division of Cancer Genetics, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Med 2:624-36. 1996
    ..The gene is most closely related by sequence to the kallikreins, to prostate-specific antigen (PSA), and to trypsin...
  72. pmc Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid
    Shin Morizane
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, CA, USA
    J Invest Dermatol 130:1297-306. 2010
    ..Thus, these variables may further control the functions of antimicrobial peptides in the skin...
  73. ncbi Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma
    Ying Dong
    Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    Cancer Res 70:2624-33. 2010
    ....
  74. ncbi Polyclonal antibodies against kallikrein-related peptidase 4 (KLK4): immunohistochemical assessment of KLK4 expression in healthy tissues and prostate cancer
    Lina Seiz
    Department of Obstetrics and Gynecology, Technical University of Munich, Germany
    Biol Chem 391:391-401. 2010
    ..Thus, our results indicate that KLK4, which is expressed in the healthy prostate, is upregulated in early-stage but not late-stage prostate cancer...
  75. ncbi Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    Hyesook Yoon
    Department of Biomedical Sciences, Florida State University, Tallahassee, Florida 32306 4300, USA
    J Biol Chem 282:31852-64. 2007
    ..One such tissue-specific cascade is proposed for the central nervous system...
  76. ncbi Human tissue kallikrein gene family: applications in cancer
    Christina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada M5G 1X5
    Cancer Lett 224:1-22. 2005
    ..PSA (hK3) is one of the human kallikreins, and is the most useful tumor marker for prostate cancer screening, diagnosis, prognosis and monitoring...
  77. ncbi Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion
    Britta Klucky
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 67:8198-206. 2007
    ..Finally, enhanced epidermal keratinocyte proliferation and migration in concert with decreased E-cadherin protein levels are confirmed in an in vivo Klk6 transgenic mouse model...
  78. ncbi Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects
    Pedro Francisco Angelo
    Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, 04044 20 Sao Paulo, Brazil
    J Biol Chem 281:3116-26. 2006
    ..This report also suggested the possible modulation of ionotropic glutamate receptors and activation of PAR 2 by hK6...
  79. ncbi Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
    Pascal Descargues
    INSERM U563, Paul Sabatier University, Place du Dr Baylac, 31059 Toulouse, Cedex 3, France
    Nat Genet 37:56-65. 2005
    ..This work identifies LEKTI as a key regulator of epidermal protease activity and degradation of desmoglein 1 as the primary pathogenic event in Netherton syndrome...
  80. pmc Contaminated heparin associated with adverse clinical events and activation of the contact system
    Takashi Kei Kishimoto
    Momenta Pharmaceuticals, the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA
    N Engl J Med 358:2457-67. 2008
    ....
  81. ncbi Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia
    Emma L Ashby
    Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, UK
    Brain Res 1363:1-10. 2010
    ..In VaD, KLK6 protein level was significantly increased in the frontal cortex. Our findings suggest that an altered KLK6 expression may contribute to vascular abnormalities in AD and VaD...
  82. pmc Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta
    P S Hart
    J Med Genet 41:545-9. 2004
  83. ncbi NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin
    Kazumasa Matsumoto-Miyai
    Division of Structural Cell Biology, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    J Neurosci 23:7727-36. 2003
    ..This neuropsin-specific L1-cleaving system is involved in NMDA receptor-dependent synaptic plasticity, such as the Schaffer collateral long-term potentiation...
  84. ncbi Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates
    Georgios Pampalakis
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion Patras 26500, Greece
    Comput Biol Chem 32:111-21. 2008
    ....
  85. ncbi Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma
    Jessica Chee
    Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Nedlands WA, Australia
    Biol Chem 388:1235-42. 2007
    ..The kallikrein serine proteases [tissue (hK1) and plasma (hKB1) kallikreins, and kallikrein-related peptidases (KRP/hK2-15)] and the mitogenic kinin peptides may have a role in ..
  86. pmc Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis
    Michael Blaber
    Department of Biomedical Sciences, Florida State University, Tallahassee, 32306 4300, USA
    Biol Chem 391:311-20. 2010
    ....
  87. ncbi Functional proteomics of kallikrein-related peptidases in ovarian cancer ascites fluid
    Katerina Oikonomopoulou
    Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada
    Biol Chem 391:381-90. 2010
    ..g., alpha2-macroglobulin, alpha1-antitrypsin). Our data suggest that the enzymatic activity of ovarian cancer-released KLKs that are detected by regular immunoassays is low in vivo and very likely regulated by proteinase inhibitors...
  88. ncbi Structural elements of kallistatin required for inhibition of angiogenesis
    Robert Q Miao
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425 2211, USA
    Am J Physiol Cell Physiol 284:C1604-13. 2003
    ..Taken together, these results indicate that the heparin-binding domain, but not the reactive site loop of kallistatin, is essential for inhibiting VEGF-induced angiogenesis...
  89. ncbi Association of kallikrein expression in nipple aspirate fluid with breast cancer risk
    Edward R Sauter
    Department of Surgery, University of Missouri, Columbia, MO 65212, USA
    Int J Cancer 108:588-91. 2004
    Human kallikreins (hK) 2, 3, 6 and 10 are expressed in breast and prostate tissue. hK2 and hK3 (prostate-specific antigen, PSA) are used to screen for prostate cancer...
  90. ncbi Compartmentalized expression of kallikrein 4 (KLK4/hK4) isoforms in prostate cancer: nuclear, cytoplasmic and secreted forms
    Y Dong
    Prostate Cancer Research Program, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Endocr Relat Cancer 12:875-89. 2005
    ....
  91. ncbi Human kallikrein 4 (KLK4) is highly expressed in serous ovarian carcinomas
    Y Dong
    Centre of Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
    Clin Cancer Res 7:2363-71. 2001
    ..Moreover, hK4 may be a candidate marker for the diagnosis and/or monitoring of ovarian epithelial carcinomas...
  92. ncbi Characterization of human kallikreins 6 and 10 in ascites fluid from ovarian cancer patients
    Liu Ying Luo
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 27:227-34. 2006
    Human kallikreins 6 (hK6) and 10 (hK10) are secreted serine proteases...
  93. ncbi Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 276:53-61. 2001
    b>Kallikreins are a subgroup of serine proteases with diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis...
  94. ncbi Utility of kallikrein-related peptidases (KLKs) as cancer biomarkers
    Nashmil Emami
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Chem 54:1600-7. 2008
    ..Among the proposed KLK cancer biomarkers, prostate-specific antigen (also known as KLK3) is the most widely recognized member in urologic oncology...
  95. ncbi Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function
    Ying Dong
    Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
    Biol Chem 389:99-109. 2008
    ..Our data also support expression patterns derived from gene duplication events in the human KLK cluster. These findings suggest that, in addition to KLK1, other related KLK enzymes will function in the exocrine pancreas...
  96. ncbi Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen
    A Yvonne Olsson
    Wallenberg Laboratory, Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, 4th Floor, University Hospital MAS, S 205 02 Malmo, Sweden
    Genomics 84:147-56. 2004
    ..This is highly interesting with respect to animal models of benign prostate hyperplasia and prostate adenocarcinoma--diseases that have been described only in humans and dogs...
  97. ncbi Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody
    Renée Ménez
    CEA, iBiTec S SIMOPRO, LTMB, Gif sur Yvette, F 91191, France
    J Mol Biol 376:1021-33. 2008
    ..The correlation of the different data with the physiological conditions under which PSA can cleave semenogelins is discussed...
  98. pmc Characterisation of human kallikrein 6/protease M expression in ovarian cancer
    X Ni
    Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Br J Cancer 91:725-31. 2004
    ..Genomic Southern analysis of 19 ovarian tumour samples suggested that gene amplification is one mechanism for the overexpression of hK6 in ovarian cancer...
  99. ncbi Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins
    Chistina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, and Department of Laboratory Medicine and Pathobiology, University of Toronto, 100 College Street, Toronto M5G 1L5, ON, Canada
    Biol Chem 387:749-59. 2006
    Human kallikrein 4 (hK4) is a member of the expanded family of human kallikreins, a group of 15 secreted proteases...
  100. ncbi Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells
    Manik C Ghosh
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 25:193-9. 2004
    ..We conclude that hK6 might play a role in the invasion and metastasis of tumour cells and may be a candidate therapeutic target...
  101. ncbi Kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis
    Chun Fang Xia
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Hypertension 43:452-9. 2004
    ....

Research Grants62

  1. KALLIKREINS-KININS AND DIABETIC VASCULAR COMPLICATIONS
    AYAD JAFFA; Fiscal Year: 2002
    ..abstract_text> ..
  2. Interactions between CNS-specific human kallikreins and the PA system in inflamma
    Michael Blaber; Fiscal Year: 2009
    ..New lines of evidence indicate that regulation of the activity of these kallikreins plays a role in the maintenance of both normal and diseased states of the CNS, and in particular, that ..
  3. Tissue Kallikrein In Immune Mediated Nephritis
    Quan Zhen Li; Fiscal Year: 2011
    ..using experimental anti-GBM antibody-induced glomerulai nephritis (AIGN) mouse model have identified tissue kallikreins (klk) as potential disease genes in immune and lupus nephritis and the impaired expression of klk in kidney ..
  4. Efficacy of Kunitz Domain 1 variants of TFPI-2 as novel antifibrinolytic agents
    MADHU SATYA BAJAJ; Fiscal Year: 2010
    ..will be effective antifibrinolytic agents without causing significant organ injury related to the inhibition of kallikreins. The proposed studies are designed to determine the efficacy and toxicity of KD1 variants using two specific ..
  5. IMMUNOGENETICS OF ANTIBODY INDUCED NEPHRITIS
    Chandra Mohan; Fiscal Year: 2012
    ..studies (of the renal cortex) comparing AIGN- sensitive and the AIGN-resistant strains have identified tissue kallikreins and PDGFRb as potential candidates within these disease loci...
  6. Prospective validation of a multi-marker prostate cancer prediction model
    Andrew J Vickers; Fiscal Year: 2013
    ..We will then test whether independent clinical laboratories can measure the panel of four kallikreins accurately using control samples...
  7. GORDON CONFERENCE--KALLIKREINS AND KININS
    Robert Colman; Fiscal Year: 1999
    ..from Investigator's Abstract): The application is to partially support the Gordon Research Conference on Kallikreins and Kinins, to be held at the Harbortown Resort in Ventura, California, on January 17-22, 1999...
  8. KALLIKREINS AND KININS IN HYPERTENSION
    HARRY MARGOLIUS; Fiscal Year: 1991
    The objective is to determine whether tissue kallikreins contribute to the pathology of genetic forms of hypertension in animal models, and ultimately, in man...
  9. SPECIFIC KALLIKREIN INHIBITORS FOR CARDIOVASCULAR STUDY
    James Burton; Fiscal Year: 1991
    Tissue kallikreins are a ubiquitous family of relatively specific serine proteases thought to be significant in the control of blood pressure and the maintenance of various renal functions...
  10. KININ RECEPTORS--MOLECULAR PROPERTIES AND REGULATION
    FREDRIK LEEB LUNDBERG; Fiscal Year: 1992
    ..in plasma and tissues from large molecular weight hormogens, kininogens, by specific serine proteases, kallikreins, in response to e.g. tissue damage and inflammatory reactions...
  11. EGF GENE REGULATION IN KIDNEY AND SUBMANDIBULAR GLAND
    RUTH GUBITS; Fiscal Year: 1990
    ..tubule (GCT) cells of the submandibular salivary gland, which also produce nerve growth factor, renin and kallikreins. In this gland, the expression of EGF is under developmental and multihormonal control...
  12. BRADYKININ RECEPTORS IN HYPERTENSION
    Julie Chao; Fiscal Year: 2000
    ..Kinins are potent vasodilating peptides that are released from precursor kininogens by kallikreins. Kinins bind to BK receptors and mediate a broad spectrum of biological effects including vasodllation, ion ..
  13. KALLIKREIN GENE EXPRESSION IN HUMAN PROSTATE CELLS
    Charles Young; Fiscal Year: 2002
    ..Prostate-specific antigen (PSA) and human glandular kallikrein (hK2) are the prostate-specific kallikreins, which are not only of clinical significance as prostate cancer markers, but also of biological importance due ..
  14. KALLIKREINS AND KININS IN HYPERTENSION
    HARRY MARGOLIUS; Fiscal Year: 1992
    ..Further scientific data for the CRISP System are unavailable at this time...
  15. CANDIDATE NEW BIOMARKER FOR BREAST CANCER DIAGNOSIS
    Eleftherios Diamandis; Fiscal Year: 2001
    ..This biomarker exhibits significant similarities with PSA and other kallikreins and it is a secreted protein...
  16. MARKERS OF ANDROGEN INDEPENDENT PROSTATE CANCER
    Robert Reiter; Fiscal Year: 2001
    ..Identification and characterization of these molecules will lead to the development of new diagnostic and therapeutic strategies for androgen refractory metastatic prostate cancer. ..
  17. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  18. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  19. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..More specifically, the kallikreins hK5, hK6, hK7, hK8, hK10, hK11 and hK14 have been shown in preliminary clinical studies to have value in ..
  20. Methodology of Phase I and II trials of anticancer CAM
    Andrew Vickers; Fiscal Year: 2004
    ....
  21. Phenotype and Gene Expression in Odontogenic Tumors
    JOHN T WRIGHT; Fiscal Year: 2010
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  22. Dendritic Cell Immunotherapy for Cervical Cancer
    Alessandro Santin; Fiscal Year: 2004
    ..This study will determine whether E7 antigen-loaded autologous DC vaccination offers the potential of therapeutic benefit for patients with HPV16 or HPV18-associated cervical cancer. ..
  23. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  24. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007
    ..abstract_text> ..
  25. C1 INHIBITOR-MEDIATED PROTECTION FROM ENDOTOXIN SHOCK
    Alvin Davis; Fiscal Year: 2009
    ..These studies will lead to improved understanding of the role played by C1INH in the cbrresistance to gram negative sepsis and endotoxin shock, and may lead to new therapies for these diseases. ..
  26. Long-term prediction of prostate cancer death from kallikreins measured in blood
    Hans Lilja; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  27. GILZ Controls TLR-Induced NF-kB Activity In Acute Asthma
    Bruce Zuraw; Fiscal Year: 2008
    ..We anticipate that this proposal will provide novel and clinically relevant data regarding the mechanisms of acute asthma exacerbations. ..
  28. C1 INHIBITOR GENE AND HEREDITARY ANGIONEUROTIC EDEMA
    Alvin Davis; Fiscal Year: 2008
    ..abstract_text> ..
  29. REGULATION OF C1 INHIBITOR SYNTHESIS
    Alvin Davis; Fiscal Year: 2004
    ..The studies proposed here will contribute both to knowledge of the regulation of C1INH itself and to the role of hormones, nuclear phosphatases and Pu-Py sequences on gene regulation in general. ..
  30. KININ/PGE INTERACTION IN CONTROL OF INTRAOCULAR PRESSURE
    JERRY WEBB; Fiscal Year: 2009
    ..abstract_text> ..
  31. ENAMEL MATRIX SERINE PROTEINASE 1
    James Simmer; Fiscal Year: 2004
    ..Accomplishing these aims will gain important insights into the action of EMSP1 in the organization, processing, turnover, and degradation of enamel matrix proteins during enamel biomineralization. ..
  32. RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    Bruce Zuraw; Fiscal Year: 2002
    ..These results will provide a necessary foundation for additional investigations into downstream inflammatory consequences of rhinovirus infection as well as potential targets for new intervention strategies. ..
  33. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
    ..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
  34. FORMS OF PROSTATE SPECIFIC ANTIGEN AND HK2 IN CANCER
    MARY HEEB; Fiscal Year: 2003
    ..Techniques will include protein purification, antibody and ELISA development, immunoblotting, enzyme activity assays, and peptide synthesis. ..
  35. PREMIER--LIFESTYLE INTERVENTION BLOOD PRESSURE CONTROL
    Laura Svetkey; Fiscal Year: 2002
    ..Results from PREMIER will provide the scientific rationale for routinely implementing comprehensive lifestyle intervention programs to control BP and ultimately prevent BP related cardiovascular disease. ..
  36. Ameloblast Differentiation In Vitro: A Step Closer to Enamel Engineering
    Pamela DenBesten; Fiscal Year: 2008
    ..In this proposal we propose to identify key factors that direct ameloblast lineage cell fate decisions as they form an enamel matrix. [unreadable] [unreadable] [unreadable]..
  37. THE SYMPATHETIC NERVOUS SYSTEM AND PROSTATIC HYPERPLASIA
    Paul Walden; Fiscal Year: 2002
    ..The second system is the spontaneously hypertensive rat, an animal model that displays elevated sympathetic activity with concomitant prostatic hyperplasia. ..
  38. REGULATION OF KALLIKREIN MK9 IN HYPERTENSION
    Mukarram Uddin; Fiscal Year: 2003
    ..Both of these laboratories are located in Nashville, TN. During retraining, facility will be developed with techniques, data collected and affiliation developed will further the missions of Meharry Medical College. ..
  39. LIPOPROTEINS, CTGF AND DIABETIC VASCULAR & RENAL DISEASE
    Ayad A Jaffa; Fiscal Year: 2010
    ..The proposed studies bridge both clinical and basic research aimed at defining the risk factors and mechanisms of macrovascular disease in diabetes. ..
  40. ANGIOSTATIN--MOLECULAR MECHANISMS AND INTERACTIONS
    DAVID SANE; Fiscal Year: 2002
    ..These studies will lead to a better understanding of the mechanisms of angiogenesis inhibition by angiostatin. ..
  41. SERINE PROTEASES FROM MAST CELLS AND SKIN
    Norman Schechter; Fiscal Year: 2002
    ..It is hoped that these studies will advance our understanding of two classes of molecules which are important to production and regulation of inflammation. ..
  42. CARIOGENIC POTENTIAL OF DENTAL PLAQUE FLUID
    HENRY MARGOLIS; Fiscal Year: 2001
    ..The long-term goal is to provide a unified picture of the caries process to be used in the design of improved delivery mechanisms for mineral ions, the assessment of caries risk, and the development of relevant in vitro models. ..
  43. MECHANISM OF HUMAN MAST CELL TRYPTASE REGULATION
    Norman Schechter; Fiscal Year: 2003
    ..Understanding the structural properties responsible for the functional instability may provide new targets for therapeutic inhibitors. ..
  44. MECHANISMS OF RISK TO DIABETIC NEPHROPATHY IN BLACKS
    Deborah Price; Fiscal Year: 2003
    ..Our goal in this study is to explore preliminary evidence that RAS activation and the combination with other polymorphic genes accounts for many Type II DM features involving renal risk and racial differences in risk. ..
  45. Hypertension Improvement Project (HIP)
    Laura Svetkey; Fiscal Year: 2008
    ..3 for the primary outcome. The HIP study will test practical interventions for improving hypertension control that can be broadly implemented and reduce CVD risk. ..
  46. The DASH-Sodium Trial: Genetic Determinants of Response
    Laura Svetkey; Fiscal Year: 2004
    ..Ultimately, increased understanding of these mechanisms will lead to improved strategies for prevention and control, both nutritional and pharmacologic, of high BP. ..
  47. Composition, Properties and structure of Tooth Enamel
    HENRY MARGOLIS; Fiscal Year: 2005
    ..Specific efforts are proposed to promote the inclusion of new, minority and female investigators, as well as persons with disabilities. ..
  48. Activation of Bradykinin B2 Receptor by Kallikrein
    ERVIN ERDOS; Fiscal Year: 2005
    ..Bradykinin (BK) and its congener, Lys-BK, are released by kallikreins from plasma kininogens...
  49. Altered Breast Methylation after Low/Hi Dose Isoflavones
    Edward Sauter; Fiscal Year: 2005
    ..abstract_text> ..
  50. Thrombostatin-A Thrombin Receptor Inhibitor
    Alvin Schmaier; Fiscal Year: 2006
    ..Second, the preparation of an IND application for its human use for one indication will be achieved. Thrombostatin(tm) has the opportunity to be a first-in-its-class thrombin receptor activation antagonist. [unreadable] [unreadable]..
  51. Novel Anticoagulant Mechanisms
    MARY HEEB; Fiscal Year: 2006
    ..We will find whether a ZPI polymorphism we identified affects function. ..
  52. PLASMA PROTEIN PHENOTYPING OF PROTHROMBOTIC MICE
    Alvin Schmaier; Fiscal Year: 2003
    ..These studies could serve as a basis for the development of a global assay(s) to predict the prothrombotic state in man. (End of Abstract.) ..
  53. PREMIER Maintenance Trial(MAINTENANCE)
    Laura Svetkey; Fiscal Year: 2007
    ..The purpose of this proposal is to develop and test two such interventions, which, if effective, should complement ongoing efforts to stem the obesity epidemic and ultimately prevent obesity-related CVD. ..
  54. Regulation and Control of Mineralization in Teeth
    HENRY MARGOLIS; Fiscal Year: 2007
    ..abstract_text> ..
  55. Therapy of thrombocytopenic disorders by chemokines
    Shahin Rafii; Fiscal Year: 2007
    ..being evaluated in phase I clinical trials, would provide the platform for assessing the role of these agents in amelioration and rapid restoration of thrombocytopenia Induced by chemotherapy and irradiation [unreadable] [unreadable]..
  56. Tissue Kallikrein, Oxidative Stress and Renal Fibrosis
    Julie Chao; Fiscal Year: 2007
    ..abstract_text> ..
  57. Breast Cancer Prediction Using Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. Evolutionary studies of mouse seminal fluid protein genes
    ROBERT KARN; Fiscal Year: 2008
    ..Disease research may benefit from studies of selection, since positive selection is often associated with human disease genes. [unreadable] [unreadable] [unreadable]..