kallikreins

Summary

Summary: Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).

Top Publications

  1. pmc Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 286:687-706. 2011
  2. doi The emerging roles of serine protease cascades in the epidermis
    Petra Ovaere
    Department of Biomedical Molecular Biology, Ghent University, Belgium
    Trends Biochem Sci 34:453-63. 2009
  3. ncbi Human kallikrein 6 as a biomarker of alzheimer's disease
    E P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Clin Biochem 33:663-7. 2000
  4. ncbi New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions
    Michael J Cork
    Pediatric Dermatology Clinic, Children s Hospital, Sheffield S10 2RX, UK
    J Allergy Clin Immunol 118:3-21; quiz 22-3. 2006
  5. doi Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer
    Jong Tae Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
    Cancer 117:2608-19. 2011
  6. pmc A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33
    Hemang Parikh
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20877, USA
    Hum Genet 127:91-9. 2010
  7. ncbi Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
    Yasuo Shinoda
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 98:1078-86. 2007
  8. pmc Contaminated heparin associated with adverse clinical events and activation of the contact system
    Takashi Kei Kishimoto
    Momenta Pharmaceuticals, the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA
    N Engl J Med 358:2457-67. 2008
  9. ncbi Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia
    Emma L Ashby
    Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, UK
    Brain Res 1363:1-10. 2010
  10. ncbi Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers
    Michael Sidiropoulos
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 26:324-36. 2005

Detail Information

Publications259 found, 100 shown here

  1. pmc Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 286:687-706. 2011
    ..The implications of KLK8 elevation and hyperactivity in desquamatory and inflammatory skin disease conditions remain to be studied...
  2. doi The emerging roles of serine protease cascades in the epidermis
    Petra Ovaere
    Department of Biomedical Molecular Biology, Ghent University, Belgium
    Trends Biochem Sci 34:453-63. 2009
    ..b>Kallikreins can form a signaling cascade to coordinate corneocyte desquamation...
  3. ncbi Human kallikrein 6 as a biomarker of alzheimer's disease
    E P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Clin Biochem 33:663-7. 2000
    ..Our aim was to examine the possible use of cerebrospinal fluid, blood and tissue, and human kallikrein 6 (hK6) concentration as a marker of AD...
  4. ncbi New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions
    Michael J Cork
    Pediatric Dermatology Clinic, Children s Hospital, Sheffield S10 2RX, UK
    J Allergy Clin Immunol 118:3-21; quiz 22-3. 2006
    ..One or more of these factors in combination might lead to a defective barrier, thereby increasing the risk of allergen penetration and succeeding inflammatory reaction, thus contributing to exacerbations of this disease...
  5. doi Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer
    Jong Tae Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
    Cancer 117:2608-19. 2011
    ..In the current study, overexpression of KLK6 was identified in colon cancer, and the possibility that KLK6 may be a suitable candidate as a tumor marker was examined...
  6. pmc A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33
    Hemang Parikh
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20877, USA
    Hum Genet 127:91-9. 2010
    ....
  7. ncbi Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
    Yasuo Shinoda
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 98:1078-86. 2007
    ..0790 and P = 0.0037, respectively). These observations indicate that KLK5, -6, -8 and -9 may be the most likely targets of the 19q13.3 amplification, and may play a crucial role in promoting cancer-cell invasion in bladder tumor...
  8. pmc Contaminated heparin associated with adverse clinical events and activation of the contact system
    Takashi Kei Kishimoto
    Momenta Pharmaceuticals, the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA
    N Engl J Med 358:2457-67. 2008
    ....
  9. ncbi Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia
    Emma L Ashby
    Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, UK
    Brain Res 1363:1-10. 2010
    ..In VaD, KLK6 protein level was significantly increased in the frontal cortex. Our findings suggest that an altered KLK6 expression may contribute to vascular abnormalities in AD and VaD...
  10. ncbi Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers
    Michael Sidiropoulos
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 26:324-36. 2005
    ..Recently, it has been shown that CpG island hypermethylation of the KLK10 gene is responsible for the tumor-specific loss of KLK10 gene expression in certain breast cancer cell lines...
  11. pmc The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer
    M Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Hospital, Athens, Greece
    Br J Cancer 100:1659-65. 2009
    ..86 beyond the clinical factors at year 1, showing that it can increase the accuracy of prediction of overall survival beyond the traditional clinical information, particularly the short-term (1 year) survival after surgery...
  12. doi The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer
    Stephen C L Koh
    Department of Obstetrics and Gynaecology, National University Health Systems NUHS, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
    Arch Gynecol Obstet 284:183-90. 2011
    To assess known cancer biomarkers CA-125, human tissue kallikreins KLK6 and KLK10, hemostatic markers and age with 5-year survival outcome from epithelial ovarian cancer.
  13. doi Epidermal barrier dysfunction in atopic dermatitis
    Michael J Cork
    The Paediatric Dermatology Clinic, Sheffield Children s Hospital, Sheffield, UK
    J Invest Dermatol 129:1892-908. 2009
    ..Our understanding of gene-environment interactions should lead to a better use of some topical products, avoidance of others, and the increased use and development of products that can repair the skin barrier...
  14. pmc Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells
    Rebecca S Henkhaus
    Cancer Biology Interdisciplinary Program, Arizona Cancer Center, The University of Arizona, 1515 N Campbell Ave, Tucson, AZ 85724, USA
    Biol Chem 389:757-64. 2008
    ..These data support the oncogenic role of KLK6 in colorectal cancer...
  15. pmc A novel protease homolog differentially expressed in breast and ovarian cancer
    A Anisowicz
    Division of Cancer Genetics, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Med 2:624-36. 1996
    ..The gene is most closely related by sequence to the kallikreins, to prostate-specific antigen (PSA), and to trypsin...
  16. pmc Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice
    James P Simmer
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 284:19110-21. 2009
    ..Instead, individual crystallites seemed to spill out of the enamel when fractured. These results demonstrate that Klk4 is essential for the removal of enamel proteins and the proper maturation of enamel crystals...
  17. ncbi The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation
    Christoph Becker-Pauly
    Institute of Zoology, Johannes Gutenberg University, Johannes von Müller Weg 6, Mainz, Germany
    J Invest Dermatol 127:1115-25. 2007
    ....
  18. ncbi The kallikrein-kinin system: current and future pharmacological targets
    Marie Eve Moreau
    Faculty of Pharmacy, University of Montreal, Canada
    J Pharmacol Sci 99:6-38. 2005
    ..This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins. The pharmacologically active kinins, which are often considered as either proinflammatory or cardioprotective, ..
  19. ncbi Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
    Panagiotis Prezas
    Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich, D 81675 Munich, Germany, and G Papanicolaou Research Center of Oncology, Saint Savas Hospital, GR 11522 Athens, Greece
    Biol Chem 387:807-11. 2006
    ..Accumulating evidence suggests that certain tissue kallikreins are part of an enzymatic cascade pathway that is activated in ovarian cancer and other malignant diseases...
  20. ncbi In silico analysis of the human kallikrein gene 6
    George M Yousef
    Discipline of Pathology, Memorial University, St John s, Toronto, Canada
    Tumour Biol 25:282-9. 2004
    b>Kallikreins are a family of 15 serine proteases clustered together on the long arm of chromosome 19. Recent reports have linked kallikreins to malignancy...
  21. ncbi Human plasma kallikrein-kinin system: physiological and biochemical parameters
    J W Bryant
    University of Mississippi, University, MS 38677 1848, USA
    Cardiovasc Hematol Agents Med Chem 7:234-50. 2009
    ..Genetic models of kallikrein deficiency are needed to evaluate the quantitative role of kallikrein and to validate whether strategies designed to activate or inhibit kallikrein may be important for regulating whole-body BK sensitivity...
  22. pmc Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model
    David Pépin
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 6:e26075. 2011
    Human tissue kallikreins (KLKs) are members of a multigene family of serine proteases aberrantly expressed in many cancer types...
  23. ncbi Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications
    E P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Clin Biochem 33:369-75. 2000
    ..One new member is the KLK6 gene, encoding for human kallikrein 6 (hK6), which is also known as zyme/protease M/neurosin. In this paper, we describe development of antibodies and a sensitive immunofluorometric procedure for hK6 protein...
  24. pmc Kallikrein gene downregulation in breast cancer
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Br J Cancer 90:167-72. 2004
    ..Probing eight normal and 24 breast cancer SAGE libraries with gene-specific tags for each of the above kallikreins indicated moderate-to-high expression densities in normal breast (27-319 tags per million; tpm, in two to five ..
  25. doi Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer
    Constantina Petraki
    Department of Pathology, Metropolitan Hospital, Athens, Greece
    Pathol Res Pract 208:104-8. 2012
    ..041). Kaplan-Meier survival curves showed that KLK6-positive patients have statistically significant lower disease-free and overall survival. In conclusion, KLK6 immunostaining is an independent prognostic marker in patients with CRC...
  26. ncbi Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients
    C V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Clin Cancer Res 7:2380-6. 2001
    ..CONCLUSIONS: Our findings indicate that KLK4 expression is associated with more aggressive forms of ovarian cancer...
  27. ncbi Human kallikrein 4: quantitative study in tissues and evidence for its secretion into biological fluids
    Christina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Chem 51:1432-42. 2005
    ....
  28. doi Dysregulation of kallikrein-related peptidases in renal cell carcinoma: potential targets of miRNAs
    Nicole M White
    Department of Laboratory Medicine and the Keenan Research Center in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Biol Chem 391:411-23. 2010
    ..The observation that KLKs could represent targets for miRNAs suggests a post-transcriptional regulatory mechanism with possible future therapeutic applications...
  29. ncbi Prognostic impact of CD68 and kallikrein 6 in human glioma
    Tadej Strojnik
    Department of Neurosurgery, University Clinical Centre Maribor, Ljubljanska 5, SI 2000 Maribor, Slovenia
    Anticancer Res 29:3269-79. 2009
    ..To evaluate the expression of CD68 and kallikrein 6 in human gliomas, and investigate their prognostic significance for survival of brain cancer patients in comparison to some known prognostic markers...
  30. doi Extracellular neurosin degrades α-synuclein in cultured cells
    Harutsugu Tatebe
    Department of Neurology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Neurosci Res 67:341-6. 2010
    ..These findings suggest that neurosin targets the extracellular alpha-synuclein...
  31. ncbi In-silico analysis of kallikrein gene expression in pancreatic and colon cancers
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Anticancer Res 24:43-51. 2004
    Human kallikreins are a cluster of 15 serine protease genes located in the chromosomal band 19q13.4, a non-randomly rearranged region in many solid tumors, including pancreatic cancer...
  32. doi Kallikrein-related peptidase 4 gene (KLK4) in prostate tumors: quantitative expression analysis and evaluation of its clinical significance
    Margaritis Avgeris
    Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens, Greece
    Prostate 71:1780-9. 2011
    ..The aim of this study is to investigate the expression status of KLK4 in PCa patients in order to reveal its utility in PCa establishment and clinical management...
  33. doi Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival
    Jyotsna Batra
    School of Life Sciences, Hormone Dependent Cancer Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia
    Int J Gynecol Cancer 20:529-36. 2010
    ..We aimed to identify whether KLK10 overexpression could be attributed to genetic variants, in particular, in hormone response elements or transcription factor binding sites...
  34. pmc KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma
    N M A White
    Division of Biomedical Sciences, Memorial University, St John s, Newfoundland, Canada
    Br J Cancer 101:1107-13. 2009
    ....
  35. ncbi Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 24:299-309. 2003
    ..297; p < 0.001). Our findings provide evidence for an association between hK5 and more aggressive forms of epithelial ovarian cancer...
  36. ncbi Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseases
    Ulf Meyer-Hoffert
    Department of Dermatology, University Hospital Schleswig Holstein, D 24105, Kiel, Germany
    Arch Immunol Ther Exp (Warsz) 57:345-54. 2009
    ..Endogenous and exogenous proteases such as kallikreins, matriptase, caspases, cathepsins, and proteases derived from microorganisms are important in the desquamation ..
  37. pmc Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines
    Alexander G Vandell
    Molecular Neuroscience Program, Mayo Medical and Graduate School, Rochester, Minnesota 55905, USA
    J Neurochem 107:855-70. 2008
    ..In this study, we test the hypothesis that kallikreins (KLKs) represent an important pool of endogenous activators of CNS PARs...
  38. ncbi Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response
    Elisabetta Bandiera
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laboratorio di Medicina Molecolare Angelo Nocivelli, University of Brescia, Piazzale Spedali Civili 1, Brescia, Italy
    Int J Gynecol Cancer 19:1015-21. 2009
    ..At the moment, the presence of KLK5 in other ovarian pathological lesions is not clearly determined. Moreover, the possibility of a spontaneous humoral immune response to KLK5 has not been studied yet...
  39. pmc Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
    Jason R Pettus
    Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Histol Histopathol 24:197-207. 2009
    ..Control experiments show lack of reactivity against KLK3 (prostate specific antigen). These results demonstrate that kallikreins 5, 7, 8, and 10 are abundantly expressed in human OSCC and may be implicated in malignant progression.
  40. doi Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival
    J Dorn
    Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
    Ann Oncol 22:1783-90. 2011
    ..Kallikrein-related peptidases, including KLK5, have been reported to play an important role in the course of the disease...
  41. pmc Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer
    Robert J Klein
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 3:611-9. 2010
    ..874 versus 0.866), providing proof in principle to clinical application for our findings...
  42. ncbi The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    J Clements
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Biol Chem 382:5-14. 2001
    The tissue kallikreins are serine proteases encoded by highly conserved multi-gene families. The rodent kallikrein (KLK) families are particularly large, consisting of 13-26 genes clustered in one chromosomal locus...
  43. ncbi Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, 15701 Athens, Greece
    Thromb Haemost 101:373-80. 2009
    Several of the novel kallikrein-related peptidases (tissue kallikreins; KLKs) are emerging new serum and/or tissue biomarkers for prostate cancer (CaP) diagnosis, prognosis and monitoring...
  44. ncbi Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 281:12743-50. 2006
    Human tissue kallikreins (hKs) are a family of fifteen serine proteases. Several lines of evidence suggest that hKs participate in proteolytic cascade pathways...
  45. doi Increased stratum corneum serine protease activity in acute eczematous atopic skin
    R Voegeli
    DSM Nutritional Products Ltd, Branch Pentapharm, Basel CH 4002, Switzerland
    Br J Dermatol 161:70-7. 2009
    ..The breakdown of epidermal barrier function in AD is associated with changes in corneocyte size and maturation, desquamation, lipid profiles, and some protease activities...
  46. doi Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus
    Mitchell G Lawrence
    Australian Prostate Cancer Research Centre Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Endocr Rev 31:407-46. 2010
    ..A more comprehensive understanding of the transcriptional regulation of kallikreins may help the field make more informed hypotheses about the physiological functions of kallikreins and their ..
  47. pmc Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid
    Shin Morizane
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, CA, USA
    J Invest Dermatol 130:1297-306. 2010
    ..Thus, these variables may further control the functions of antimicrobial peptides in the skin...
  48. ncbi Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions
    Y Wang
    Institut fur Neurobiochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Cell Mol Life Sci 65:237-52. 2008
    ..Therefore, understanding the interaction among brain trypsin, serpins and PARs will provide invaluable tools for regulating normal brain functions and for the clinical treatment of neural disorders...
  49. ncbi Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma
    Ying Dong
    Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    Cancer Res 70:2624-33. 2010
    ....
  50. doi Polyclonal antibodies against kallikrein-related peptidase 4 (KLK4): immunohistochemical assessment of KLK4 expression in healthy tissues and prostate cancer
    Lina Seiz
    Department of Obstetrics and Gynecology, Technical University of Munich, Germany
    Biol Chem 391:391-401. 2010
    ..Thus, our results indicate that KLK4, which is expressed in the healthy prostate, is upregulated in early-stage but not late-stage prostate cancer...
  51. doi A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition
    Georgios Pampalakis
    Department of Pharmacy, University of Patras, Rion Patras, Greece
    Cancer Res 69:3779-87. 2009
    ..We suggest that KLK6 is an epigenetically regulated tumor suppressor in human breast cancer and provide ways of pharmacologic modulation...
  52. ncbi Human tissue kallikrein gene family: applications in cancer
    Christina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada M5G 1X5
    Cancer Lett 224:1-22. 2005
    ..PSA (hK3) is one of the human kallikreins, and is the most useful tumor marker for prostate cancer screening, diagnosis, prognosis and monitoring...
  53. ncbi Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    Hyesook Yoon
    Department of Biomedical Sciences, Florida State University, Tallahassee, Florida 32306 4300, USA
    J Biol Chem 282:31852-64. 2007
    ..One such tissue-specific cascade is proposed for the central nervous system...
  54. ncbi Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion
    Britta Klucky
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 67:8198-206. 2007
    ..Finally, enhanced epidermal keratinocyte proliferation and migration in concert with decreased E-cadherin protein levels are confirmed in an in vivo Klk6 transgenic mouse model...
  55. ncbi Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects
    Pedro Francisco Angelo
    Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, 04044 20 Sao Paulo, Brazil
    J Biol Chem 281:3116-26. 2006
    ..This report also suggested the possible modulation of ionotropic glutamate receptors and activation of PAR 2 by hK6...
  56. ncbi Human kallikrein 4 (KLK4) is highly expressed in serous ovarian carcinomas
    Y Dong
    Centre of Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
    Clin Cancer Res 7:2363-71. 2001
    ..Moreover, hK4 may be a candidate marker for the diagnosis and/or monitoring of ovarian epithelial carcinomas...
  57. doi Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates
    Georgios Pampalakis
    Department of Pharmacy, School of Health Sciences, University of Patras, Rion Patras 26500, Greece
    Comput Biol Chem 32:111-21. 2008
    ....
  58. ncbi Compartmentalized expression of kallikrein 4 (KLK4/hK4) isoforms in prostate cancer: nuclear, cytoplasmic and secreted forms
    Y Dong
    Prostate Cancer Research Program, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Endocr Relat Cancer 12:875-89. 2005
    ....
  59. ncbi Structural elements of kallistatin required for inhibition of angiogenesis
    Robert Q Miao
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425 2211, USA
    Am J Physiol Cell Physiol 284:C1604-13. 2003
    ..Taken together, these results indicate that the heparin-binding domain, but not the reactive site loop of kallistatin, is essential for inhibiting VEGF-induced angiogenesis...
  60. ncbi Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma
    Jessica Chee
    Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Nedlands WA, Australia
    Biol Chem 388:1235-42. 2007
    ..The kallikrein serine proteases [tissue (hK1) and plasma (hKB1) kallikreins, and kallikrein-related peptidases (KRP/hK2-15)] and the mitogenic kinin peptides may have a role in ..
  61. pmc Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis
    Michael Blaber
    Department of Biomedical Sciences, Florida State University, Tallahassee, 32306 4300, USA
    Biol Chem 391:311-20. 2010
    ....
  62. doi High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis
    Heuzé Vourc h Nathalie
    INSERM, Universite Francois Rabelais de Tours, Tours, France
    J Cell Mol Med 13:4014-22. 2009
    ..We conclude that a high concentration of KLK6 is an indicator of tumour proliferation and an independent predictive factor in NSCLC...
  63. doi Functional proteomics of kallikrein-related peptidases in ovarian cancer ascites fluid
    Katerina Oikonomopoulou
    Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada
    Biol Chem 391:381-90. 2010
    ..g., alpha2-macroglobulin, alpha1-antitrypsin). Our data suggest that the enzymatic activity of ovarian cancer-released KLKs that are detected by regular immunoassays is low in vivo and very likely regulated by proteinase inhibitors...
  64. ncbi Association of kallikrein expression in nipple aspirate fluid with breast cancer risk
    Edward R Sauter
    Department of Surgery, University of Missouri, Columbia, MO 65212, USA
    Int J Cancer 108:588-91. 2004
    Human kallikreins (hK) 2, 3, 6 and 10 are expressed in breast and prostate tissue. hK2 and hK3 (prostate-specific antigen, PSA) are used to screen for prostate cancer...
  65. ncbi Characterization of human kallikreins 6 and 10 in ascites fluid from ovarian cancer patients
    Liu Ying Luo
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 27:227-34. 2006
    Human kallikreins 6 (hK6) and 10 (hK10) are secreted serine proteases...
  66. doi Utility of kallikrein-related peptidases (KLKs) as cancer biomarkers
    Nashmil Emami
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Chem 54:1600-7. 2008
    ..Among the proposed KLK cancer biomarkers, prostate-specific antigen (also known as KLK3) is the most widely recognized member in urologic oncology...
  67. ncbi Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 276:53-61. 2001
    b>Kallikreins are a subgroup of serine proteases with diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis...
  68. doi Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function
    Ying Dong
    Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
    Biol Chem 389:99-109. 2008
    ..Our data also support expression patterns derived from gene duplication events in the human KLK cluster. These findings suggest that, in addition to KLK1, other related KLK enzymes will function in the exocrine pancreas...
  69. ncbi Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen
    A Yvonne Olsson
    Wallenberg Laboratory, Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, 4th Floor, University Hospital MAS, S 205 02 Malmo, Sweden
    Genomics 84:147-56. 2004
    ..This is highly interesting with respect to animal models of benign prostate hyperplasia and prostate adenocarcinoma--diseases that have been described only in humans and dogs...
  70. ncbi Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 280:14628-35. 2005
    ..Our findings suggest that hK5 may be implicated in tumor progression, particularly in invasion and angiogenesis, and may represent a novel therapeutic target...
  71. ncbi Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody
    Renée Ménez
    CEA, iBiTec S SIMOPRO, LTMB, Gif sur Yvette, F 91191, France
    J Mol Biol 376:1021-33. 2008
    ..The correlation of the different data with the physiological conditions under which PSA can cleave semenogelins is discussed...
  72. pmc Characterisation of human kallikrein 6/protease M expression in ovarian cancer
    X Ni
    Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Br J Cancer 91:725-31. 2004
    ..Genomic Southern analysis of 19 ovarian tumour samples suggested that gene amplification is one mechanism for the overexpression of hK6 in ovarian cancer...
  73. ncbi Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins
    Chistina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, and Department of Laboratory Medicine and Pathobiology, University of Toronto, 100 College Street, Toronto M5G 1L5, ON, Canada
    Biol Chem 387:749-59. 2006
    Human kallikrein 4 (hK4) is a member of the expanded family of human kallikreins, a group of 15 secreted proteases...
  74. ncbi Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells
    Manik C Ghosh
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 25:193-9. 2004
    ..We conclude that hK6 might play a role in the invasion and metastasis of tumour cells and may be a candidate therapeutic target...
  75. ncbi Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression
    Andrew J Ramsay
    Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Corner Musk Ave and Blamey St, Kelvin Grove, Queensland 4059, Australia
    J Biol Chem 283:12293-304. 2008
    ..These data provide insight into KLK4-mediated cell signaling and suggest that signals induced by this enzyme via PARs may be important in prostate cancer...
  76. doi Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer
    Jin Ju Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak ro, Yuseong Gu, Daejeon 305 806, Republic of Korea
    Tumour Biol 33:731-8. 2012
    ..This study shows that KLK6 is significantly upregulated and secreted in gastric cancer tissues and sera, suggesting that KLK6 might be used as a potential biomarker and therapeutic target for gastric cancer...
  77. ncbi Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord
    Ryuji Terayama
    Department of Anatomy, Asahikawa Medical College, Asahikawa 078 8510, Japan
    Glia 48:91-101. 2004
    ..These findings suggest that each subpopulation of oligodendrocytes based on the expression of neuropsin and protease M/neurosin has different roles in the response of the spinal cord to injury as well as in normal homeostasis...
  78. ncbi Effect of testosterone administration on serum and urine kallikrein concentrations in female-to-male transsexuals
    Margrita H Slagter
    Department of Endocrinology, Vrije Universiteit University Medical Centre, Amsterdam, The Netherlands, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Chem 52:1546-51. 2006
    Concentrations of human tissue kallikreins (hKs), a group of 15 secreted serine proteases found in many tissues, are modulated by steroid hormones in cancer cell lines...
  79. ncbi Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Cancer Res 61:3425-31. 2001
    b>Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK (KLK1) encodes for an enzyme that is involved in posttranslational processing of polypeptide precursors...
  80. ncbi Development of an immunofluorometric assay and quantification of human kallikrein 7 in tissue extracts and biological fluids
    Tadaaki Kishi
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Chem 50:709-16. 2004
    ..The aim of this study was to develop a sensitive and specific immunoassay for hK7 and to examine the distribution of hK7 in tissue extracts and biological fluids...
  81. ncbi Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme
    A Skytt
    ASTRA HASSLE AB, Umea, Sweden
    Biochem Biophys Res Commun 211:586-9. 1995
    ..It is concluded that SCCE belongs to the family of serine endoproteinases specific for amino acid residues with aromatic side chains in the P1 position...
  82. ncbi Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle
    J D Hooper
    Centre for Molecular Biotechnology, Queensland University of Technology, Brisbane, Queensland, 4001, Australia
    Genomics 73:117-22. 2001
    The kallikreins are a subfamily of serine proteases encoded in human, mouse, and rat by highly conserved tightly clustered multigene families...
  83. ncbi Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Am J Clin Pathol 123:360-8. 2005
    ..hK4 expression in carcinoma cells of effusions or solid tumors does not predict survival...
  84. pmc Characterization of kallikrein-related peptidase 4 glycosylations
    Yasuo Yamakoshi
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Eisenhower Place, Ann Arbor, MI 48108, USA
    Eur J Oral Sci 119:234-40. 2011
    ..We conclude that pig KLK4 has NA2, NA2F, and NA3 N-glycan cores with no, or with one, two, or three sialic acids. Mouse KLK4 has NA2, NA2F, and NA3F N-glycan cores with no, or with one or two sialic acids...
  85. doi Reference intervals and biological variation for kallikrein 6: influence of age and renal failure
    Eduardo Martínez-Morillo
    Samuel Lunenfeld Research Institute, Joseph and Wolf Lebovic Health Centre, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Chem Lab Med 50:931-4. 2012
    ..The aim of this study was to establish a reference interval and estimate the biological variation of KLK6 in serum samples of adults. Furthermore, levels of this protein in patients with renal failure were also studied...
  86. ncbi Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
    Cecile Caubet
    UMR5165 Epidermis Differentiation and Rheumatoid Autoimmunity, CNRS P Sabatier University Institut Fédératif de Recherche 30 and INSERM CNRS Université P Sabatier Centre Hospitalier Universitaire, Toulouse, France
    J Invest Dermatol 122:1235-44. 2004
    ..These results strongly suggest that the two kalikreins are involved in desquamation. A model is proposed for desquamation that could be regulated by a precisely controlled protease-protease inhibitor balance...
  87. doi The plasma bradykinin-forming pathways and its interrelationships with complement
    Allen P Kaplan
    Medical University of South Carolina, Department of Medicine, 96 Jonathan Lucas Street, Charleston, SC 29425, United States
    Mol Immunol 47:2161-9. 2010
    ....
  88. doi Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
    Anke Ohler
    Institute of Zoology, Cell and Matrix Biology, Johannes Gutenberg University, Mainz, Germany
    Biol Chem 391:455-60. 2010
    ..In summary, we demonstrate a specific interaction between meprin metalloproteases and kallikrein-related peptidases, revealing possible interactions within the proteolytic web...
  89. doi The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6)
    Jane Bayani
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Clin Chem Lab Med 50:211-33. 2012
    ..This comprehensive review will summarise the current findings of KLK6 pathophysiology and discuss its potential as a viable biomarker...
  90. ncbi Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer Res 59:4252-6. 1999
    ....
  91. pmc Gene network analyses point to the importance of human tissue kallikreins in melanoma progression
    Waleska K Martins
    Hospital A, C, Camargo, Sao Paulo, Brazil
    BMC Med Genomics 4:76. 2011
    ..A wide variety of high-throughput microarray platforms have been used to identify molecular targets associated with biological and clinical tumor phenotypes by comparing samples representing distinct pathological states...
  92. doi Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro
    Takashi Kasai
    Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Neurosci Lett 436:52-6. 2008
    ....
  93. doi Heparin comes clean
    Lawrence B Schwartz
    N Engl J Med 358:2505-9. 2008
  94. ncbi Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry
    Christina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5 Canada
    Clin Chem 48:1232-40. 2002
    ..Because the protein has not been detected in any human tissue, we attempted to develop immunologic methods for hK4 analysis and use them to detect hK4 in healthy and cancerous tissue extracts and biological fluids...
  95. ncbi Characterization of KLK4 expression and detection of KLK4-specific antibody in prostate cancer patient sera
    Craig H Day
    Corixa Corporation, 1124 Columbia Street, Suite 200, Seattle, Washington, WA 98104, USA
    Oncogene 21:7114-20. 2002
    ....
  96. ncbi Prostate-specific antigen and human glandular kallikrein: two kallikreins of the human prostate
    P Henttu
    Biocenter Oulu, University of Oulu, Finland
    Ann Med 26:157-64. 1994
    ..It is a serine protease that belongs to the subgroup of kallikreins, among which it is very similar to a putative enzyme called human glandular kallikrein (hGK-1)...
  97. doi Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7
    Thiago S P Teixeira
    Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triangulo Mineiro, Uberaba, MG, Brazil
    Bioorg Med Chem Lett 21:6112-5. 2011
    ..In addition, the docking results suggested that the formation of hydrogen bonds at the oxyanion hole is essential for a good inhibitor...
  98. ncbi Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients
    Ray Wilkinson
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, QLD 4101, Australia
    Cancer Immunol Immunother 61:169-79. 2012
    ..These data demonstrate that KLK4 is an immunogenic molecule capable of inducing CTL responses and identify it as an attractive target for prostate and ovarian cancer immunotherapy...
  99. ncbi Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem)
    T B Rosatelli
    Dermatology, Department of Medicine, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, Monte Alegre, 14049 900, Ribeirao Preto, SP, Brazil
    Br J Dermatol 152:650-7. 2005
    ..Pemphigus foliaceus (PF) is an autoimmune blistering disease of unknown aetiology, which is endemic in Brazil. Although the pathogenesis of PF is still unknown, proteins of the contact system have been implicated...
  100. ncbi Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats
    D W Chung
    Biochemistry 25:2410-7. 1986
    ..These repeat sequences are also homologous to those in human factor XI. The light chain of plasma kallikrein contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases...
  101. ncbi Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases
    N Komatsu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada, M5G 1X5
    Br J Dermatol 153:274-81. 2005
    Human tissue kallikreins are a gene family (KLK1-KLK15) encoding for 15 secretory serine proteases (hK1-hK15)...

Research Grants86

  1. KALLIKREINS-KININS AND DIABETIC VASCULAR COMPLICATIONS
    AYAD JAFFA; Fiscal Year: 2002
    ..abstract_text> ..
  2. Long-term prediction of prostate cancer death from kallikreins measured in blood
    Hans Lilja; Fiscal Year: 2010
    ..If so, a single blood test could be used to identify men at highest risk from prostate cancer and particular efforts could then be made for intensive screening and chemoprevention for these individuals. ..
  3. Tissue Kallikrein In Immune Mediated Nephritis
    Quan Zhen Li; Fiscal Year: 2010
    ..using experimental anti-GBM antibody-induced glomerulai nephritis (AIGN) mouse model have identified tissue kallikreins (klk) as potential disease genes in immune and lupus nephritis and the impaired expression of klk in kidney ..
  4. Tissue Kallikrein In Immune Mediated Nephritis
    Quan Zhen Li; Fiscal Year: 2009
    ..using experimental anti-GBM antibody-induced glomerulai nephritis (AIGN) mouse model have identified tissue kallikreins (klk) as potential disease genes in immune and lupus nephritis and the impaired expression of klk in kidney ..
  5. GORDON CONFERENCE--KALLIKREINS AND KININS
    Robert Colman; Fiscal Year: 1999
    ..from Investigator's Abstract): The application is to partially support the Gordon Research Conference on Kallikreins and Kinins, to be held at the Harbortown Resort in Ventura, California, on January 17-22, 1999...
  6. Efficacy of Kunitz Domain 1 variants of TFPI-2 as novel antifibrinolytic agents
    MADHU SATYA BAJAJ; Fiscal Year: 2010
    ..will be effective antifibrinolytic agents without causing significant organ injury related to the inhibition of kallikreins. The proposed studies are designed to determine the efficacy and toxicity of KD1 variants using two specific ..
  7. Efficacy of Kunitz Domain 1 variants of TFPI-2 as novel antifibrinolytic agents
    MADHU BAJAJ; Fiscal Year: 2009
    ..will be effective antifibrinolytic agents without causing significant organ injury related to the inhibition of kallikreins. The proposed studies are designed to determine the efficacy and toxicity of KD1 variants using two specific ..
  8. KALLIKREINS AND KININS IN HYPERTENSION
    HARRY MARGOLIUS; Fiscal Year: 1990
    The objective is to determine whether tissue kallikreins contribute to the pathology of genetic forms of hypertension in animal models, and ultimately, in man...
  9. IMMUNOGENETICS OF ANTIBODY INDUCED NEPHRITIS
    Chandra Mohan; Fiscal Year: 2009
    ..studies (of the renal cortex) comparing AIGN- sensitive and the AIGN-resistant strains have identified tissue kallikreins and PDGFRb as potential candidates within these disease loci...
  10. IMMUNOGENETICS OF ANTIBODY INDUCED NEPHRITIS
    Chandra Mohan; Fiscal Year: 2010
    ..studies (of the renal cortex) comparing AIGN- sensitive and the AIGN-resistant strains have identified tissue kallikreins and PDGFRb as potential candidates within these disease loci...
  11. SPECIFIC KALLIKREIN INHIBITORS FOR CARDIOVASCULAR STUDY
    James Burton; Fiscal Year: 1990
    Tissue kallikreins are a ubiquitous family of relatively specific serine proteases thought to be significant in the control of blood pressure and the maintenance of various renal functions...
  12. Activation of Bradykinin B2 Receptor by Kallikrein
    ERVIN ERDOS; Fiscal Year: 2002
    ..Bradykinin (BK) and its congener, Lys-BK, are released by kallikreins from plasma kininogens...
  13. Activation of Bradykinin B2 Receptor by Kallikrein
    ERVIN ERDOS; Fiscal Year: 2004
    ..Bradykinin (BK) and its congener, Lys-BK, are released by kallikreins from plasma kininogens...
  14. Activation of Bradykinin B2 Receptor by Kallikrein
    ERVIN ERDOS; Fiscal Year: 2003
    ..Bradykinin (BK) and its congener, Lys-BK, are released by kallikreins from plasma kininogens...
  15. Activation of Bradykinin B2 Receptor by Kallikrein
    ERVIN ERDOS; Fiscal Year: 2005
    ..Bradykinin (BK) and its congener, Lys-BK, are released by kallikreins from plasma kininogens...
  16. Interactions between CNS-specific human kallikreins and the PA system in inflamma
    Michael Blaber; Fiscal Year: 2009
    ..New lines of evidence indicate that regulation of the activity of these kallikreins plays a role in the maintenance of both normal and diseased states of the CNS, and in particular, that ..
  17. Interactions between CNS-specific human kallikreins and the PA system in inflamma
    Michael Blaber; Fiscal Year: 2007
    ..New lines of evidence indicate that regulation of the activity of these kallikreins plays a role in the maintenance of both normal and diseased states of the CNS, and in particular, that ..
  18. REGULATION AND FUNCTION OF RENAL KALLIKREIN
    Julie Chao; Fiscal Year: 1993
    ..Tissue kallikreins, a subgroup of closely related serine proteinases, have diverse functions depending on their location and ..
  19. REGULATION AND FUNCTION OF RENAL KALLIKREIN
    Julie Chao; Fiscal Year: 1992
    ..Tissue kallikreins, a subgroup of closely related serine proteinases, have diverse functions depending on their location and ..
  20. REGULATION AND FUNCTION OF RENAL KALLIKREIN
    Julie Chao; Fiscal Year: 1991
    ..Tissue kallikreins, a subgroup of closely related serine proteinases, have diverse functions depending on their location and ..
  21. BIOCHEMISTRY AND REGULATION OF TISSUE KALLIKREINS
    Julie Chao; Fiscal Year: 1990
    ..cDNA, oligonucleotides and kallikrein genomic clones will be used to elucidate the regulation and function of kallikreins. The objective is facilitated by our recent finding of kallikrein induction in estrogen-treated rat pituitary ..
  22. KININ RECEPTORS--MOLECULAR PROPERTIES AND REGULATION
    FREDRIK LEEB LUNDBERG; Fiscal Year: 1990
    ..in plasma and tissues from large molecular weight hormogens, kininogens, by specific serine proteases, kallikreins, in response to e.g. tissue damage and inflammatory reactions...
  23. BRADYKININ RECEPTORS IN HYPERTENSION
    Julie Chao; Fiscal Year: 2000
    ..Kinins are potent vasodilating peptides that are released from precursor kininogens by kallikreins. Kinins bind to BK receptors and mediate a broad spectrum of biological effects including vasodllation, ion ..
  24. REGULATION OF EPIDERMAL GROWTH FACTOR AND ITS ENZYMES
    SHUPING WU; Fiscal Year: 1992
    ..coli to large quantities and the biochemical evidence of in vitro proEGF processing by kallikreins will be determined by their binding and catalytic activity to synthetic peptides or fusion proteins of proEGF ..
  25. BRADYKININ RECEPTORS IN HYPERTENSION
    Julie Chao; Fiscal Year: 1999
    ..Kinins are potent vasodilating peptides that are released from precursor kininogens by kallikreins. Kinins bind to BK receptors and mediate a broad spectrum of biological effects including vasodllation, ion ..
  26. HYDROLYTIC ENZYMES OF BLOOD IN HEALTH AND DISEASE
    VIRGINIA DONALDSON; Fiscal Year: 1980
    ..In preliminary work aimed to examine the role of a distinctive polypeptide kinin from HANE plasma in normal person, antibody to this kinin will be prepared and characterized...
  27. EGF GENE REGULATION IN KIDNEY AND SUBMANDIBULAR GLAND
    RUTH GUBITS; Fiscal Year: 1990
    ..tubule (GCT) cells of the submandibular salivary gland, which also produce nerve growth factor, renin and kallikreins. In this gland, the expression of EGF is under developmental and multihormonal control...
  28. KININ RECEPTORS--MOLECULAR PROPERTIES AND REGULATION
    FREDRIK LEEB LUNDBERG; Fiscal Year: 1993
    ..trauma and injury from high molecular weight prohormones, kininogens, through the action of specific proteases, kallikreins. The pharmacological action of kinins, which include vasodilatation, increased vascular permeability, smooth ..
  29. SALIVARY KALLIKREINS: GENE EXPRESSION AND SECRETION
    Lee Chao; Fiscal Year: 1991
    ..studies are designed to achieve a systematic and comprehensive analysis of the multigene family of salivary kallikreins in the rat and human...
  30. HUMAN KALLIKREINS AS NOVEL MARKERS OF PROSTATE CANCER
    Charles Young; Fiscal Year: 2001
    ..The major goal of these studies will be the development of the most practical and accurate assays to improve the detection, diagnosis and management of prostate cancer. ..
  31. KININ SYSTEM INHIBITORS
    John Stewart; Fiscal Year: 1980
    ..We have developed a new assay system for kallikreins, and will use it to try to find inhibitors of kallikrein, particularly of urinary kallikrein, which appears to ..
  32. SPORE IN PROSTATE CANCER
    Donald Tindall; Fiscal Year: 2004
    ..D., Daniel J. Schaid, Ph.D., James R. Cerhan: M.D., Ph.D., Steven J. Jacobsen, M.D., Ph.D.) Project 2: Human Kallikreins as Novel Markers of Prostate Cancer (Charles Y.F. Young, George G. Klee, M.D., Ph.D. Donald J. Tindall, Ph.D...
  33. SPORE IN PROSTATE CANCER
    Donald Tindall; Fiscal Year: 2002
    ..D., Daniel J. Schaid, Ph.D., James R. Cerhan: M.D., Ph.D., Steven J. Jacobsen, M.D., Ph.D.) Project 2: Human Kallikreins as Novel Markers of Prostate Cancer (Charles Y.F. Young, George G. Klee, M.D., Ph.D. Donald J. Tindall, Ph.D...
  34. SPORE IN PROSTATE CANCER
    Donald Tindall; Fiscal Year: 2003
    ..D., Daniel J. Schaid, Ph.D., James R. Cerhan: M.D., Ph.D., Steven J. Jacobsen, M.D., Ph.D.) Project 2: Human Kallikreins as Novel Markers of Prostate Cancer (Charles Y.F. Young, George G. Klee, M.D., Ph.D. Donald J. Tindall, Ph.D...
  35. SPORE IN PROSTATE CANCER
    Donald Tindall; Fiscal Year: 2001
    ..D., Daniel J. Schaid, Ph.D., James R. Cerhan: M.D., Ph.D., Steven J. Jacobsen, M.D., Ph.D.) Project 2: Human Kallikreins as Novel Markers of Prostate Cancer (Charles Y.F. Young, George G. Klee, M.D., Ph.D. Donald J. Tindall, Ph.D...
  36. SPORE IN PROSTATE CANCER
    Donald Tindall; Fiscal Year: 2005
    ..D., Daniel J. Schaid, Ph.D., James R. Cerhan: M.D., Ph.D., Steven J. Jacobsen, M.D., Ph.D.) Project 2: Human Kallikreins as Novel Markers of Prostate Cancer (Charles Y.F. Young, George G. Klee, M.D., Ph.D. Donald J. Tindall, Ph.D...
  37. KALLIKREIN GENE EXPRESSION IN HUMAN PROSTATE CELLS
    Charles Young; Fiscal Year: 2000
    ..Prostate-specific antigen (PSA) and human glandular kallikrein (hK2) are the prostate-specific kallikreins, which are not only of clinical significance as prostate cancer markers, but also of biological importance due ..
  38. KALLIKREIN GENE EXPRESSION IN HUMAN PROSTATE CELLS
    Charles Young; Fiscal Year: 2000
    ..Prostate-specific antigen (PSA) and human glandular kallikrein (hK2) are the prostate-specific kallikreins, which are not only of clinical significance as prostate cancer markers, but also of biological importance due ..
  39. KALLIKREIN GENE EXPRESSION IN HUMAN PROSTATE CELLS
    Charles Young; Fiscal Year: 2001
    ..Prostate-specific antigen (PSA) and human glandular kallikrein (hK2) are the prostate-specific kallikreins, which are not only of clinical significance as prostate cancer markers, but also of biological importance due ..
  40. KALLIKREIN GENE EXPRESSION IN HUMAN PROSTATE CELLS
    Charles Young; Fiscal Year: 2002
    ..Prostate-specific antigen (PSA) and human glandular kallikrein (hK2) are the prostate-specific kallikreins, which are not only of clinical significance as prostate cancer markers, but also of biological importance due ..
  41. KALLIKREIN GENE EXPRESSION IN HUMAN PROSTATE CELLS
    Charles Young; Fiscal Year: 1999
    ..Prostate-specific antigen (PSA) and human glandular kallikrein (hK2) are the prostate-specific kallikreins, which are not only of clinical significance as prostate cancer markers, but also of biological importance due ..
  42. KALLIKREINS AND KININS IN HYPERTENSION
    HARRY MARGOLIUS; Fiscal Year: 1992
    ..Further scientific data for the CRISP System are unavailable at this time...
  43. CANDIDATE NEW BIOMARKER FOR BREAST CANCER DIAGNOSIS
    Eleftherios Diamandis; Fiscal Year: 2000
    ..This biomarker exhibits significant similarities with PSA and other kallikreins and it is a secreted protein...
  44. CANDIDATE NEW BIOMARKER FOR BREAST CANCER DIAGNOSIS
    Eleftherios Diamandis; Fiscal Year: 2001
    ..This biomarker exhibits significant similarities with PSA and other kallikreins and it is a secreted protein...
  45. MARKERS OF ANDROGEN INDEPENDENT PROSTATE CANCER
    Robert Reiter; Fiscal Year: 1999
    ..Identification and characterization of these molecules will lead to the development of new diagnostic and therapeutic strategies for androgen refractory metastatic prostate cancer. ..
  46. MARKERS OF ANDROGEN INDEPENDENT PROSTATE CANCER
    Robert Reiter; Fiscal Year: 2000
    ..Identification and characterization of these molecules will lead to the development of new diagnostic and therapeutic strategies for androgen refractory metastatic prostate cancer. ..
  47. MARKERS OF ANDROGEN INDEPENDENT PROSTATE CANCER
    Robert Reiter; Fiscal Year: 2001
    ..Identification and characterization of these molecules will lead to the development of new diagnostic and therapeutic strategies for androgen refractory metastatic prostate cancer. ..
  48. HUMAN KININ & FIBRINOLYTIC SYSTEMS AND RENAL DISEASE
    JOCELYN SPRAGG; Fiscal Year: 1980
    ..kallikrein will be used for the development of specific immunoassays and for the localization of glandular kallikreins immunohistochemically...
  49. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  50. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2006
    ..More specifically, the kallikreins hK5, hK6, hK7, hK8, hK10, hK11 and hK14 have been shown in preliminary clinical studies to have value in ..
  51. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2007
    ..More specifically, the kallikreins hK5, hK6, hK7, hK8, hK10, hK11 and hK14 have been shown in preliminary clinical studies to have value in ..
  52. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..More specifically, the kallikreins hK5, hK6, hK7, hK8, hK10, hK11 and hK14 have been shown in preliminary clinical studies to have value in ..
  53. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  54. Regulation and Function of Kallikreins in Spinal Cord Injury and Repair
    Isobel Scarisbrick; Fiscal Year: 2009
    ..applicant): The objective of this proposal is to investigate the activity and potential mechanism of action of kallikreins in traumatic spinal cord injury with a focus on their roles in mediating axon injury, astrogliosis, and ..
  55. Regulation and Function of Kallikreins in Spinal Cord Injury and Repair
    Isobel A Scarisbrick; Fiscal Year: 2010
    ..applicant): The objective of this proposal is to investigate the activity and potential mechanism of action of kallikreins in traumatic spinal cord injury with a focus on their roles in mediating axon injury, astrogliosis, and ..
  56. Regulation and Function of Kallikreins in Spinal Cord Injury and Repair
    Isobel Scarisbrick; Fiscal Year: 2008
    The objective of this proposal is to investigate the activity and potential mechanism of action of kallikreins in traumatic spinal cord injury with a focus on their roles in mediating axon injury, astrogliosis, and alteration of the ..
  57. Methodology of Phase I and II trials of anticancer CAM
    Andrew Vickers; Fiscal Year: 2004
    ....
  58. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2002
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  59. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2005
    ..abstract_text> ..
  60. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2001
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  61. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2000
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  62. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2004
    ..abstract_text> ..
  63. Phenotype and Gene Expression in Odontogenic Tumors
    John Wright; Fiscal Year: 2009
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  64. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  65. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007
    ..abstract_text> ..
  66. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2003
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  67. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2006
    ..abstract_text> ..
  68. Phenotype and Gene Expression in Odontogenic Tumors
    John Wright; Fiscal Year: 2007
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. [unreadable] [unreadable] [unreadable]..
  69. Phenotype and Gene Expression in Odontogenic Tumors
    John Wright; Fiscal Year: 2006
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. [unreadable] [unreadable] [unreadable]..