kallikreins

Summary

Summary: Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).

Top Publications

  1. ncbi The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors
    U Hengst
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 276:535-40. 2001
  2. ncbi Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 286:687-706. 2011
  3. ncbi The emerging roles of serine protease cascades in the epidermis
    Petra Ovaere
    Department of Biomedical Molecular Biology, Ghent University, Belgium
    Trends Biochem Sci 34:453-63. 2009
  4. ncbi A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33
    Hemang Parikh
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20877, USA
    Hum Genet 127:91-9. 2010
  5. ncbi New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions
    Michael J Cork
    Pediatric Dermatology Clinic, Children s Hospital, Sheffield S10 2RX, UK
    J Allergy Clin Immunol 118:3-21; quiz 22-3. 2006
  6. ncbi Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus
    Mitchell G Lawrence
    Australian Prostate Cancer Research Centre Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Endocr Rev 31:407-46. 2010
  7. ncbi Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
    Yasuo Shinoda
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 98:1078-86. 2007
  8. ncbi The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer
    Stephen C L Koh
    Department of Obstetrics and Gynaecology, National University Health Systems NUHS, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
    Arch Gynecol Obstet 284:183-90. 2011
  9. ncbi Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers
    Michael Sidiropoulos
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 26:324-36. 2005
  10. ncbi The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer
    M Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Hospital, Athens, Greece
    Br J Cancer 100:1659-65. 2009

Research Grants

  1. KALLIKREINS-KININS AND DIABETIC VASCULAR COMPLICATIONS
    AYAD JAFFA; Fiscal Year: 2002
  2. IMMUNOGENETICS OF ANTIBODY INDUCED NEPHRITIS
    Chandra Mohan; Fiscal Year: 2010
  3. Activation of Bradykinin B2 Receptor by Kallikrein
    ERVIN ERDOS; Fiscal Year: 2005
  4. Interactions between CNS-specific human kallikreins and the PA system in inflamma
    Michael Blaber; Fiscal Year: 2007
  5. REGULATION AND FUNCTION OF RENAL KALLIKREIN
    Julie Chao; Fiscal Year: 1993
  6. BIOCHEMISTRY AND REGULATION OF TISSUE KALLIKREINS
    Julie Chao; Fiscal Year: 1990
  7. KININ RECEPTORS--MOLECULAR PROPERTIES AND REGULATION
    FREDRIK LEEB LUNDBERG; Fiscal Year: 1993
  8. KININ SYSTEM INHIBITORS
    John Stewart; Fiscal Year: 1980
  9. KALLIKREIN GENE EXPRESSION IN HUMAN PROSTATE CELLS
    Charles Young; Fiscal Year: 2002
  10. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2007

Detail Information

Publications210 found, 100 shown here

  1. ncbi The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors
    U Hengst
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 276:535-40. 2001
    ..PEBP immunoreactivity is found on the surface of Rat-1 fibroblast cells and although its sequence contains no secretion signal, PEBP-H(6) can be purified from the conditioned medium upon recombinant expression...
  2. ncbi Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 286:687-706. 2011
    ..The implications of KLK8 elevation and hyperactivity in desquamatory and inflammatory skin disease conditions remain to be studied...
  3. ncbi The emerging roles of serine protease cascades in the epidermis
    Petra Ovaere
    Department of Biomedical Molecular Biology, Ghent University, Belgium
    Trends Biochem Sci 34:453-63. 2009
    ..b>Kallikreins can form a signaling cascade to coordinate corneocyte desquamation...
  4. ncbi A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33
    Hemang Parikh
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20877, USA
    Hum Genet 127:91-9. 2010
    ....
  5. ncbi New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions
    Michael J Cork
    Pediatric Dermatology Clinic, Children s Hospital, Sheffield S10 2RX, UK
    J Allergy Clin Immunol 118:3-21; quiz 22-3. 2006
    ..One or more of these factors in combination might lead to a defective barrier, thereby increasing the risk of allergen penetration and succeeding inflammatory reaction, thus contributing to exacerbations of this disease...
  6. ncbi Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus
    Mitchell G Lawrence
    Australian Prostate Cancer Research Centre Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Endocr Rev 31:407-46. 2010
    ..A more comprehensive understanding of the transcriptional regulation of kallikreins may help the field make more informed hypotheses about the physiological functions of kallikreins and their ..
  7. ncbi Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
    Yasuo Shinoda
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 98:1078-86. 2007
    ..0790 and P = 0.0037, respectively). These observations indicate that KLK5, -6, -8 and -9 may be the most likely targets of the 19q13.3 amplification, and may play a crucial role in promoting cancer-cell invasion in bladder tumor...
  8. ncbi The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer
    Stephen C L Koh
    Department of Obstetrics and Gynaecology, National University Health Systems NUHS, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
    Arch Gynecol Obstet 284:183-90. 2011
    To assess known cancer biomarkers CA-125, human tissue kallikreins KLK6 and KLK10, hemostatic markers and age with 5-year survival outcome from epithelial ovarian cancer.
  9. ncbi Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers
    Michael Sidiropoulos
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 26:324-36. 2005
    ..Recently, it has been shown that CpG island hypermethylation of the KLK10 gene is responsible for the tumor-specific loss of KLK10 gene expression in certain breast cancer cell lines...
  10. ncbi The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer
    M Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Hospital, Athens, Greece
    Br J Cancer 100:1659-65. 2009
    ..86 beyond the clinical factors at year 1, showing that it can increase the accuracy of prediction of overall survival beyond the traditional clinical information, particularly the short-term (1 year) survival after surgery...
  11. ncbi Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid
    Shin Morizane
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, CA, USA
    J Invest Dermatol 130:1297-306. 2010
    ..Thus, these variables may further control the functions of antimicrobial peptides in the skin...
  12. ncbi Contaminated heparin associated with adverse clinical events and activation of the contact system
    Takashi Kei Kishimoto
    Momenta Pharmaceuticals, the Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA
    N Engl J Med 358:2457-67. 2008
    ....
  13. ncbi Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells
    Rebecca S Henkhaus
    Cancer Biology Interdisciplinary Program, Arizona Cancer Center, The University of Arizona, 1515 N Campbell Ave, Tucson, AZ 85724, USA
    Biol Chem 389:757-64. 2008
    ..These data support the oncogenic role of KLK6 in colorectal cancer...
  14. ncbi Epidermal barrier dysfunction in atopic dermatitis
    Michael J Cork
    The Paediatric Dermatology Clinic, Sheffield Children s Hospital, Sheffield, UK
    J Invest Dermatol 129:1892-908. 2009
    ..Our understanding of gene-environment interactions should lead to a better use of some topical products, avoidance of others, and the increased use and development of products that can repair the skin barrier...
  15. ncbi The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation
    Christoph Becker-Pauly
    Institute of Zoology, Johannes Gutenberg University, Johannes von Müller Weg 6, Mainz, Germany
    J Invest Dermatol 127:1115-25. 2007
    ....
  16. ncbi The kallikrein-kinin system: current and future pharmacological targets
    Marie Eve Moreau
    Faculty of Pharmacy, University of Montreal, Canada
    J Pharmacol Sci 99:6-38. 2005
    ..This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins. The pharmacologically active kinins, which are often considered as either proinflammatory or cardioprotective, ..
  17. ncbi Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines
    Alexander G Vandell
    Molecular Neuroscience Program, Mayo Medical and Graduate School, Rochester, Minnesota 55905, USA
    J Neurochem 107:855-70. 2008
    ..In this study, we test the hypothesis that kallikreins (KLKs) represent an important pool of endogenous activators of CNS PARs...
  18. ncbi Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseases
    Ulf Meyer-Hoffert
    Department of Dermatology, University Hospital Schleswig Holstein, D 24105, Kiel, Germany
    Arch Immunol Ther Exp (Warsz) 57:345-54. 2009
    ..Endogenous and exogenous proteases such as kallikreins, matriptase, caspases, cathepsins, and proteases derived from microorganisms are important in the desquamation ..
  19. ncbi Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma
    Jessica Chee
    Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, Nedlands WA, Australia
    Biol Chem 388:1235-42. 2007
    ..The kallikrein serine proteases [tissue (hK1) and plasma (hKB1) kallikreins, and kallikrein-related peptidases (KRP/hK2-15)] and the mitogenic kinin peptides may have a role in ..
  20. ncbi Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival
    J Dorn
    Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
    Ann Oncol 22:1783-90. 2011
    ..Kallikrein-related peptidases, including KLK5, have been reported to play an important role in the course of the disease...
  21. ncbi KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma
    N M A White
    Division of Biomedical Sciences, Memorial University, St John s, Newfoundland, Canada
    Br J Cancer 101:1107-13. 2009
    ....
  22. ncbi Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
    Jason R Pettus
    Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Histol Histopathol 24:197-207. 2009
    ..Control experiments show lack of reactivity against KLK3 (prostate specific antigen). These results demonstrate that kallikreins 5, 7, 8, and 10 are abundantly expressed in human OSCC and may be implicated in malignant progression.
  23. ncbi Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response
    Elisabetta Bandiera
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laboratorio di Medicina Molecolare Angelo Nocivelli, University of Brescia, Piazzale Spedali Civili 1, Brescia, Italy
    Int J Gynecol Cancer 19:1015-21. 2009
    ..At the moment, the presence of KLK5 in other ovarian pathological lesions is not clearly determined. Moreover, the possibility of a spontaneous humoral immune response to KLK5 has not been studied yet...
  24. ncbi Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival
    Jyotsna Batra
    School of Life Sciences, Hormone Dependent Cancer Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia
    Int J Gynecol Cancer 20:529-36. 2010
    ..We aimed to identify whether KLK10 overexpression could be attributed to genetic variants, in particular, in hormone response elements or transcription factor binding sites...
  25. ncbi Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 24:299-309. 2003
    ..297; p < 0.001). Our findings provide evidence for an association between hK5 and more aggressive forms of epithelial ovarian cancer...
  26. ncbi Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
    Anke Ohler
    Institute of Zoology, Cell and Matrix Biology, Johannes Gutenberg University, Mainz, Germany
    Biol Chem 391:455-60. 2010
    ..In summary, we demonstrate a specific interaction between meprin metalloproteases and kallikrein-related peptidases, revealing possible interactions within the proteolytic web...
  27. ncbi Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, 15701 Athens, Greece
    Thromb Haemost 101:373-80. 2009
    Several of the novel kallikrein-related peptidases (tissue kallikreins; KLKs) are emerging new serum and/or tissue biomarkers for prostate cancer (CaP) diagnosis, prognosis and monitoring...
  28. ncbi Increased stratum corneum serine protease activity in acute eczematous atopic skin
    R Voegeli
    DSM Nutritional Products Ltd, Branch Pentapharm, Basel CH 4002, Switzerland
    Br J Dermatol 161:70-7. 2009
    ..The breakdown of epidermal barrier function in AD is associated with changes in corneocyte size and maturation, desquamation, lipid profiles, and some protease activities...
  29. ncbi Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer
    Robert J Klein
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 3:611-9. 2010
    ..874 versus 0.866), providing proof in principle to clinical application for our findings...
  30. ncbi The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    J Clements
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Biol Chem 382:5-14. 2001
    The tissue kallikreins are serine proteases encoded by highly conserved multi-gene families. The rodent kallikrein (KLK) families are particularly large, consisting of 13-26 genes clustered in one chromosomal locus...
  31. ncbi Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 281:12743-50. 2006
    Human tissue kallikreins (hKs) are a family of fifteen serine proteases. Several lines of evidence suggest that hKs participate in proteolytic cascade pathways...
  32. ncbi Human tissue kallikrein gene family: applications in cancer
    Christina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada M5G 1X5
    Cancer Lett 224:1-22. 2005
    ..PSA (hK3) is one of the human kallikreins, and is the most useful tumor marker for prostate cancer screening, diagnosis, prognosis and monitoring...
  33. ncbi Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion
    Britta Klucky
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 67:8198-206. 2007
    ..Finally, enhanced epidermal keratinocyte proliferation and migration in concert with decreased E-cadherin protein levels are confirmed in an in vivo Klk6 transgenic mouse model...
  34. ncbi Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
    Panagiotis Prezas
    Clinical Research Unit, Department of Obstetrics and Gynecology, Technical University of Munich, D-81675 Munich, Germany, and G. Papanicolaou Research Center of Oncology, Saint Savas Hospital, GR-11522 Athens, Greece
    Biol Chem 387:807-11. 2006
    ..Accumulating evidence suggests that certain tissue kallikreins are part of an enzymatic cascade pathway that is activated in ovarian cancer and other malignant diseases...
  35. ncbi In-silico analysis of kallikrein gene expression in pancreatic and colon cancers
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Anticancer Res 24:43-51. 2004
    Human kallikreins are a cluster of 15 serine protease genes located in the chromosomal band 19q13.4, a non-randomly rearranged region in many solid tumors, including pancreatic cancer...
  36. ncbi Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    Hyesook Yoon
    Department of Biomedical Sciences, Florida State University, Tallahassee, Florida 32306 4300, USA
    J Biol Chem 282:31852-64. 2007
    ..One such tissue-specific cascade is proposed for the central nervous system...
  37. ncbi Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects
    Pedro Francisco Angelo
    Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, 04044 20 Sao Paulo, Brazil
    J Biol Chem 281:3116-26. 2006
    ..This report also suggested the possible modulation of ionotropic glutamate receptors and activation of PAR 2 by hK6...
  38. ncbi Characterization of human kallikreins 6 and 10 in ascites fluid from ovarian cancer patients
    Liu-Ying Luo
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 27:227-34. 2006
    OBJECTIVES: Human kallikreins 6 (hK6) and 10 (hK10) are secreted serine proteases...
  39. ncbi Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 276:53-61. 2001
    b>Kallikreins are a subgroup of serine proteases with diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis...
  40. ncbi A novel protease homolog differentially expressed in breast and ovarian cancer
    A Anisowicz
    Division of Cancer Genetics, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Med 2:624-36. 1996
    ..The gene is most closely related by sequence to the kallikreins, to prostate-specific antigen (PSA), and to trypsin...
  41. ncbi Utility of kallikrein-related peptidases (KLKs) as cancer biomarkers
    Nashmil Emami
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Chem 54:1600-7. 2008
    ..Among the proposed KLK cancer biomarkers, prostate-specific antigen (also known as KLK3) is the most widely recognized member in urologic oncology...
  42. ncbi Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function
    Ying Dong
    Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
    Biol Chem 389:99-109. 2008
    ..Our data also support expression patterns derived from gene duplication events in the human KLK cluster. These findings suggest that, in addition to KLK1, other related KLK enzymes will function in the exocrine pancreas...
  43. ncbi Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins
    Chistina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, and Department of Laboratory Medicine and Pathobiology, University of Toronto, 100 College Street, Toronto M5G 1L5, ON, Canada
    Biol Chem 387:749-59. 2006
    Human kallikrein 4 (hK4) is a member of the expanded family of human kallikreins, a group of 15 secreted proteases...
  44. ncbi Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells
    Manik C Ghosh
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 25:193-9. 2004
    ..We conclude that hK6 might play a role in the invasion and metastasis of tumour cells and may be a candidate therapeutic target...
  45. ncbi Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody
    Renée Ménez
    CEA, iBiTec S SIMOPRO, LTMB, Gif sur Yvette, F 91191, France
    J Mol Biol 376:1021-33. 2008
    ..The correlation of the different data with the physiological conditions under which PSA can cleave semenogelins is discussed...
  46. ncbi Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression
    Andrew J Ramsay
    Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Corner Musk Ave and Blamey St, Kelvin Grove, Queensland 4059, Australia
    J Biol Chem 283:12293-304. 2008
    ..These data provide insight into KLK4-mediated cell signaling and suggest that signals induced by this enzyme via PARs may be important in prostate cancer...
  47. ncbi Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 280:14628-35. 2005
    ..Our findings suggest that hK5 may be implicated in tumor progression, particularly in invasion and angiogenesis, and may represent a novel therapeutic target...
  48. ncbi Characterisation of human kallikrein 6/protease M expression in ovarian cancer
    X Ni
    Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Br J Cancer 91:725-31. 2004
    ..Genomic Southern analysis of 19 ovarian tumour samples suggested that gene amplification is one mechanism for the overexpression of hK6 in ovarian cancer...
  49. ncbi Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen
    A Yvonne Olsson
    Wallenberg Laboratory, Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, 4th Floor, University Hospital MAS, S 205 02 Malmo, Sweden
    Genomics 84:147-56. 2004
    ..This is highly interesting with respect to animal models of benign prostate hyperplasia and prostate adenocarcinoma--diseases that have been described only in humans and dogs...
  50. ncbi Steroid hormone regulation of the human kallikrein 10 (KLK10) gene in cancer cell lines and functional characterization of the KLK10 gene promoter
    Liu-Ying Luo
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Clin Chim Acta 337:115-26. 2003
    ..CONCLUSIONS: Estrogens, androgens and progestins modulate KLK10 expression through their own receptors but this regulation is not mediated by steroid hormone response elements in the promoter of the KLK10 gene...
  51. ncbi Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis
    U Breitenbach
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 117:634-40. 2001
    ..These results establish a novel link between expression of an as yet ill-defined serine protease and skin carcinogenesis...
  52. ncbi Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome
    Jean Pierre Hachem
    Dienst Dermatologie, Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium
    J Invest Dermatol 126:1609-21. 2006
    ..LEKTI co-localizes within the SC with kallikreins 5 and 7 and inhibits both SP...
  53. ncbi Human kallikrein 8: immunoassay development and identification in tissue extracts and biological fluids
    Tadaaki Kishi
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Clin Chem 49:87-96. 2003
    ..This assay can be used to explore the potential of hK8 as a marker of cancer or other conditions...
  54. ncbi Identification of mK1, a true tissue (glandular) kallikrein of mouse submandibular gland: tissue distribution and a comparison of kinin-releasing activity with other submandibular kallikreins
    K Hosoi
    Department of Oral Physiology, Meikai University School of Dentistry, Saitama
    J Biochem 115:137-43. 1994
    ..Acting on the two kininogen substrates, kallikreins mK22, mK9, and proteinase F, but not proteinase P, specifically released bradykinin, suggesting that the former ..
  55. ncbi The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Br J Cancer 87:1294-300. 2002
    ..KLK15 is up-regulated by androgens in breast cancer cell lines. Time-course and blocking experiments suggest that this regulation is mediated through the androgen receptor...
  56. ncbi Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases
    N Komatsu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada, M5G 1X5
    Br J Dermatol 153:274-81. 2005
    BACKGROUND: Human tissue kallikreins are a gene family (KLK1-KLK15) encoding for 15 secretory serine proteases (hK1-hK15)...
  57. ncbi Human plasma kallikrein-kinin system: physiological and biochemical parameters
    J W Bryant
    University of Mississippi, University, MS 38677 1848, USA
    Cardiovasc Hematol Agents Med Chem 7:234-50. 2009
    ..Genetic models of kallikrein deficiency are needed to evaluate the quantitative role of kallikrein and to validate whether strategies designed to activate or inhibit kallikrein may be important for regulating whole-body BK sensitivity...
  58. ncbi Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats
    D W Chung
    Biochemistry 25:2410-7. 1986
    ..These repeat sequences are also homologous to those in human factor XI. The light chain of plasma kallikrein contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases...
  59. ncbi Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene
    Wei Huang
    Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    World J Gastroenterol 14:5810-5. 2008
    ..To study the inhibitory effect of baculovirus-mediated normal epithelial cell specific-1 (NES1) gene therapy on gastric cancer (GC) in vitro and in vivo...
  60. ncbi Human kallikrein 13 involvement in extracellular matrix degradation
    Carl Kapadia
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Biochem Biophys Res Commun 323:1084-90. 2004
    ..Growing evidence suggests that many kallikreins are differentially expressed in cancer and may play a role in metastasis...
  61. ncbi The emerging roles of human tissue kallikreins in cancer
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G1X5, Canada
    Nat Rev Cancer 4:876-90. 2004
    Human tissue kallikreins (hKs), which are encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with diverse expression patterns and physiological roles...
  62. ncbi Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease
    G P Christophi
    Department of Physical Medicine and Rehabilitation, Mayo Medical and Graduate Schools, Rochester, Minnesota, USA
    J Neurochem 91:1439-49. 2004
    ....
  63. ncbi Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3
    Angeliki Magklara
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Int J Cancer 100:507-14. 2002
    ..We examined previously the steroid hormone regulation of 2 known androgen-regulated kallikreins, KLK3 (encoding PSA) and KLK2 (encoding human kallikrein 2 or hK2) in BT-474, T-47D, ZR75-1, MCF-7, MFM-223 and ..
  64. ncbi Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer
    Lianna G Kyriakopoulou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5G 1X5 Canada
    Clin Biochem 36:135-43. 2003
    ..6). CONCLUSIONS: We conclude that higher KLK7 expression in ovarian cancer tissue is associated with poorer prognosis of ovarian cancer patients, especially those with lower grade disease and those who have been optimally debulked...
  65. ncbi Functional roles of human kallikrein-related peptidases
    Georgia Sotiropoulou
    Department of Pharmacy, University of Patras, Rion, 26500 Rion Patras, Greece
    J Biol Chem 284:32989-94. 2009
    ..In addition, KLKs have emerged as versatile signaling molecules. In summary, KLKs represent attractive biomarkers for clinical applications and potential therapeutic targets for common human pathologies...
  66. ncbi Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins
    C C Drinkwater
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Biochemistry 26:6750-6. 1987
    ..The isolation of three distinct genes from the one mouse strain indicates that the conflicting data previously reported in the literature are not a result of allelic polymorphisms or strain differences...
  67. ncbi Cellular basis for the differential response of mouse kallikrein genes to hormonal induction
    B H Van Leeuwen
    EMBO J 6:1705-13. 1987
    ..The hormonally mediated differentiation of some, but not all, of these cells has different effects on kallikrein gene expression--mGK-6 is repressed while other kallikreins are induced--leading to non-uniform distribution of expression.
  68. ncbi Disparate tissue-specific expression of members of the tissue kallikrein multigene family of the rat
    R J MacDonald
    Department of Biochemistry, Molecular Immunology Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9140, USA
    J Biol Chem 271:13684-90. 1996
    ..A gradient of diversity of expression corresponds to the order of the genes within the kallikrein family locus...
  69. ncbi Mouse glandular kallikrein genes. Identification, structure, and expression of the renal kallikrein gene
    B H Van Leeuwen
    J Biol Chem 261:5529-35. 1986
    Glandular kallikreins are a highly homologous subfamily of serine proteases encoded by 25 genes in the mouse...
  70. ncbi Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration
    Isobel A Scarisbrick
    Program for Molecular Neuroscience, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Biol Chem 389:739-45. 2008
    ..These novel findings suggest that KLK1 and KLK6 may serve as serological markers of progressive MS and contribute directly to the development of neurological disability by promoting axonal injury and neuron cell death...
  71. ncbi Molecular cloning and characterization of two rat renal kallikrein genes
    Y P Chen
    Department of Biochemistry, Medical University of South Carolina, Charleston 29425
    Biochemistry 27:7189-96. 1988
    b>Kallikreins compose a multigene family coding for a subgroup of serine proteases, which are involved in the processing of bioactive peptides...
  72. ncbi Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin
    Nashmil Emami
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L5, Canada
    J Biol Chem 283:3031-41. 2008
    ..We are proposing a putative cascade model, operating through multiple KLKs. Identification of novel members of such proteolytic cascades will aid in further defining mechanisms involved in seminal/skin homeostasis...
  73. ncbi Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo
    Hans Torma
    Dermatology and Venereology Section, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 128:1212-9. 2008
    ..Changes in protein expression of KLK-5 were also found. In conclusion, SLS-induced skin barrier defects induce altered mRNA expression of keratinocyte differentiation markers and enzymes degrading corneodesmosomes...
  74. ncbi Characterization of genes encoding rat tonin and a kallikrein-like serine protease
    S Y Shai
    Department of Biochemistry, Medical University of South Carolina, Charleston 29425
    Biochemistry 28:5334-43. 1989
    Tissue kallikreins are a group of serine proteases which may function as peptide hormone processing enzymes. Two rat kallikrein genomic clones (RSKG-5 and RSKG-50) were sequenced and characterized...
  75. ncbi The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Ont M5G 1X5, Toronto, Canada
    Gene 254:119-28. 2000
    ....
  76. ncbi Evolution of the rat kallikrein gene family: gene conversion leads to functional diversity
    D R Wines
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
    J Mol Evol 32:476-92. 1991
    ..These analyses indicate an important role for gene conversion in the evolution of the functional diversity of these duplicated genes...
  77. ncbi The epigenetic basis for the aberrant expression of kallikreins in human cancers
    Georgios Pampalakis
    Department of Pharmacy, School of Health Sciences, University of Patras, GR 26500 Rion Patras, Greece, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Biol Chem 387:795-9. 2006
    ..Epigenetic regulation provides a new mechanism for the pharmacological modulation of kallikreins in human cancers with putative therapeutic implications.
  78. ncbi Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?
    I E Ekholm
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, Sweden
    J Invest Dermatol 114:56-63. 2000
    ....
  79. ncbi Kallikrein-related peptidases: proteolysis and signaling in cancer, the new frontier
    Katerina Oikonomopoulou
    Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada
    Biol Chem 391:299-310. 2010
    ..These enzymes can potentially control cell/tissue behavior by regulating PAR activation in specific settings and disease stages...
  80. ncbi Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs)
    Katerina Oikonomopoulou
    Department of Laboratory Medicine and Pathobiology, University of Toronto and Mount Sinai Hospital, Toronto M5G 1X5, ON, Canada
    Biol Chem 387:817-24. 2006
    We tested the hypothesis that human tissue kallikreins (hKs) may regulate signal transduction by cleaving and activating proteinase-activated receptors (PARs)...
  81. ncbi Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease
    Sachiko I Blaber
    Institute of Molecular Biophysics, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, USA
    FASEB J 18:920-2. 2004
    ....
  82. ncbi Human kallikrein 13 expression in normal tissues: an immunohistochemical study
    Constantina D Petraki
    Department of Pathology, Evangelismos Hospital, Athens, Greece
    J Histochem Cytochem 51:493-501. 2003
    ..IHC) localization of hK13 in normal human tissues and compare it with the expression of two other kallikreins, hK6 and hK10...
  83. ncbi Characterization of recombinant and brain neuropsin, a plasticity-related serine protease
    C Shimizu
    Division of Structural Cell Biology, Nara Institute of Science and Technology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    J Biol Chem 273:11189-96. 1998
    ..Taken together, these results indicate that this protease, which is enzymatically novel, has significant limbic effects by changing the extracellular matrix environment...
  84. ncbi Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)
    Nathalie Beaufort
    Unité de Défense Innée et Inflammation INSERM E0336, Département de Médecine Moléculaire, Institut Pasteur, F 75015 Paris, France
    Biol Chem 387:217-22. 2006
    ..hK4 may thus modulate the tumor-associated uPA/uPAR-system activity by either activating the pro-enzyme form of uPA or cleaving the cell surface-associated uPA receptor...
  85. ncbi Kallikreins as microRNA targets: an in silico and experimental-based analysis
    Tsz fung F Chow
    Department of Laboratory Medicine, and the Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto M5B 1W8, Canada
    Biol Chem 389:731-8. 2008
    ..They have been shown to control many biological processes including cancer pathogenesis. Kallikreins (KLKs) are a family of serine proteases that are attracting interest as cancer biomarkers...
  86. ncbi Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases
    Mitchell G Lawrence
    Hormone Dependent Cancer Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Cells Tissues Organs 185:111-5. 2007
    ....
  87. ncbi Development of an immunofluorometric assay for human kallikrein 15 (KLK15) and identification of KLK15 in tissues and biological fluids
    Julie L V Shaw
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada, M5G 1X5
    Clin Biochem 40:104-10. 2007
    ..The assay was then used to examine levels of KLK15 in tissues and biological fluids...
  88. ncbi Human tissue kallikrein 9: production of recombinant proteins and specific antibodies
    Nader Memari
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 1L5, ON, Canada
    Biol Chem 387:733-40. 2006
    Human tissue kallikreins (genes, KLKs; proteins, hKs) are a subgroup of hormonally regulated serine proteases...
  89. ncbi Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity
    Kazuya Shinmura
    First Department of Pathology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Hum Mutat 24:273-4. 2004
    ..These results indicate that individuals with the c.457+2C/C genotype have no substantial expression of hK12 serine protease...
  90. ncbi Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Biochem Biophys Res Commun 276:125-33. 2000
    b>Kallikreins are a subgroup of serine proteases with diverse physiological functions. Recently, growing evidence indicates that many kallikrein genes are involved in malignancy...
  91. ncbi Cloning and characterization of mouse klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity
    H Matsui
    Division of Biological Sciences, Hokkaido University, Sapporo, Japan
    Eur J Biochem 267:6858-65. 2000
    ..Insulin-like growth factor binding protein-3 was also hydrolyzed by recombinant mKlk27. These results suggest that mKlk27 plays an important role in association with the function of the adult mouse testis...
  92. ncbi Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1
    S D Mikolajczyk
    Hybritech Incorporated, a subsidiary of Beckman Coulter Inc, San Diego, CA 92196 9006, USA
    Int J Cancer 81:438-42. 1999
    ..Our current results suggest that the increased hK2 expression in prostate cancer tissues could influence cancer biology not only by activation of uPA but also by inactivation of its primary inhibitor, PAI-1...
  93. ncbi Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR
    T K Takayama
    Departments of Biochemistry and Urology, University of Washington, Box 357350, Seattle, WA 98195 7350, USA
    Biochemistry 40:1679-87. 2001
    ..These results indicate that prostin may be a physiological activator of pro-PSA following its own proteolytic activation, as part of a cascade system involving a series of serine protease precursor proteins in the prostate...
  94. ncbi Cardiovascular phenotypes of kinin B2 receptor- and tissue kallikrein-deficient mice
    Fabien Trabold
    Departement de Pharmacologie, Faculte de Medecine Paris Sud, INSERM 00 01, Le Kremlin Bicetre, France
    Hypertension 40:90-5. 2002
    ..The phenotypic differences observed between TK-/- and B2-/- mice could be underlain by tissue kallikrein kinin-independent effect and/or kinin B1 receptor activation...
  95. ncbi Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice
    Chenjuan Yao
    Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima shi, Tokushima 770 8504, Japan
    J Biol Chem 281:7968-76. 2006
    ..Our present results thus suggest kallikrein mK13 is a plausible candidate for the processing enzyme for pro-IL-1beta in the SMG of mice...
  96. ncbi The kallikrein gene 5 splice variant 2 is a new biomarker for breast and ovarian cancer
    George M Yousef
    Discipline of Laboratory Medicine, Memorial University, St. John's, Toronto, Canada
    Tumour Biol 25:221-7. 2004
    The presence of more than one mRNA form for the same gene is common among kallikreins, and many of the kallikrein splice variants may hold significant clinical value...
  97. ncbi Induction of vascular leakage and blood pressure lowering through kinin release by a serine proteinase from Aeromonas sobria
    Takahisa Imamura
    Department of Molecular Pathology, Faculty of Medical and Pharmaceutical Services, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556
    J Immunol 177:8723-9. 2006
    ..ASP-specific inhibitors, and kinin receptor antagonists, might prove useful for the treatment or prevention of this fatal disease...
  98. ncbi Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 282:2405-22. 2007
    ..These findings may have clinical implications for the management of cancer and other disorders in which KLK14 activity is elevated...
  99. ncbi Targeted disruption of the bradykinin B(2) receptor gene in mice alters the ontogeny of the renin-angiotensin system
    I V Yosipiv
    Section of Pediatric Nephrology, Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 281:F795-801. 2001
    ..6-fold, P < 0.05). We conclude that 1) bradykinin stimulates renin gene expression, 2) renal kallikrein is regulated via a negative feedback loop involving the B(2) receptor, and 3) Ao, ACE, and AT(1) are not bradykinin-target genes...
  100. ncbi Activity and functional significance of the renal kallikrein-kinin-system in polycystic kidney disease of the rat
    Claude Braun
    V Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, Germany
    Kidney Int 61:2149-56. 2002
    ..Activity and functional significance of the renal kallikrein-kinin-system in polycystic kidney disease of the rat...
  101. ncbi Growth factor-binding proteases in the murine submaxillary gland: isolation of a cDNA clone
    H Ronne
    Department of Cell Research, University of Uppsala, Sweden
    EMBO J 2:1561-4. 1983
    ....

Research Grants85

  1. KALLIKREINS-KININS AND DIABETIC VASCULAR COMPLICATIONS
    AYAD JAFFA; Fiscal Year: 2002
    ..abstract_text> ..
  2. IMMUNOGENETICS OF ANTIBODY INDUCED NEPHRITIS
    Chandra Mohan; Fiscal Year: 2010
    ..studies (of the renal cortex) comparing AIGN- sensitive and the AIGN-resistant strains have identified tissue kallikreins and PDGFRb as potential candidates within these disease loci...
  3. Activation of Bradykinin B2 Receptor by Kallikrein
    ERVIN ERDOS; Fiscal Year: 2005
    ..Bradykinin (BK) and its congener, Lys-BK, are released by kallikreins from plasma kininogens...
  4. Interactions between CNS-specific human kallikreins and the PA system in inflamma
    Michael Blaber; Fiscal Year: 2007
    ..New lines of evidence indicate that regulation of the activity of these kallikreins plays a role in the maintenance of both normal and diseased states of the CNS, and in particular, that ..
  5. REGULATION AND FUNCTION OF RENAL KALLIKREIN
    Julie Chao; Fiscal Year: 1993
    ..Tissue kallikreins, a subgroup of closely related serine proteinases, have diverse functions depending on their location and ..
  6. BIOCHEMISTRY AND REGULATION OF TISSUE KALLIKREINS
    Julie Chao; Fiscal Year: 1990
    ..cDNA, oligonucleotides and kallikrein genomic clones will be used to elucidate the regulation and function of kallikreins. The objective is facilitated by our recent finding of kallikrein induction in estrogen-treated rat pituitary ..
  7. KININ RECEPTORS--MOLECULAR PROPERTIES AND REGULATION
    FREDRIK LEEB LUNDBERG; Fiscal Year: 1993
    ..trauma and injury from high molecular weight prohormones, kininogens, through the action of specific proteases, kallikreins. The pharmacological action of kinins, which include vasodilatation, increased vascular permeability, smooth ..
  8. KININ SYSTEM INHIBITORS
    John Stewart; Fiscal Year: 1980
    ..We have developed a new assay system for kallikreins, and will use it to try to find inhibitors of kallikrein, particularly of urinary kallikrein, which appears to ..
  9. KALLIKREIN GENE EXPRESSION IN HUMAN PROSTATE CELLS
    Charles Young; Fiscal Year: 2002
    ..Prostate-specific antigen (PSA) and human glandular kallikrein (hK2) are the prostate-specific kallikreins, which are not only of clinical significance as prostate cancer markers, but also of biological importance due ..
  10. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2007
    ..More specifically, the kallikreins hK5, hK6, hK7, hK8, hK10, hK11 and hK14 have been shown in preliminary clinical studies to have value in ..
  11. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  12. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  13. Regulation and Function of Kallikreins in Spinal Cord Injury and Repair
    Isobel Scarisbrick; Fiscal Year: 2009
    The objective of this proposal is to investigate the activity and potential mechanism of action of kallikreins in traumatic spinal cord injury with a focus on their roles in mediating axon injury, astrogliosis, and alteration of the ..
  14. Methodology of Phase I and II trials of anticancer CAM
    Andrew Vickers; Fiscal Year: 2004
    ....
  15. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007
    ..abstract_text> ..
  16. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  17. Phenotype and Gene Expression in Odontogenic Tumors
    John Wright; Fiscal Year: 2007
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..