Genomes and Genes
Summary: Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.
Publications285 found, 100 shown here
- The mechanism of inactivation of human factor V and human factor Va by activated protein CM Kalafatis
Department of Biochemistry, University of Vermont, College of Medicine, Burlington 05405 0068
J Biol Chem 269:31869-80. 1994The cleavage of human factor V and human factor Va by human activated protein C (APC) was analyzed in the absence and presence of phospholipid vesicles containing 75% phosphatidylcholine (PC) and 25% phosphatidylserine (PS)...
- Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterizedMarten Steen
Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, Sweden
Blood 102:1316-22. 2003b>Factor V (FV) deficiency, also known as parahemophilia, is a rare bleeding disorder. Herein we investigate the first reported missense mutation associated with FV deficiency, Ala221Val, assigned as FV New Brunswick...
- Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control studyLeena M Hiltunen
Department of Hemostasis, Finnish Red Cross Blood Service, Helsinki, Finland
Thromb Res 124:167-73. 2009..ABO blood group has been associated with thrombotic disorders and pre-eclampsia. We assessed ABO blood group, seven thrombophilia associated polymorphisms, and anti-beta2-glycoprotein I antibodies as risk factors for pre-eclampsia...
- Varied prevalence of factor V G1691A (Leiden) and prothrombin G20210A single nucleotide polymorphisms among ArabsWassim Y Almawi
Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
J Thromb Thrombolysis 20:163-8. 2005b>Factor V G1691A (FV-Leiden) and prothrombin (PRT) G20210A single nucleotide polymorphisms (SNPs) are major inherited risk factors of venous thromboembolism...
- Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screeningP M Ridker
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
JAMA 277:1305-7. 1997To estimate ethnic-specific prevalence rates of factor V Leiden, an inherited defect of hemostasis associated with risk of venous thrombosis.
- Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA studyE R Pomp
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 6:632-7. 2008..Objective: In the MEGA study, we evaluated pregnancy and the postpartum period as risk factors for venous thrombosis in 285 patients and 857 control subjects...
- A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosisS R Poort
Hemostasis and Thrombosis Research Center, Leiden University Hospital, The Netherlands
Blood 88:3698-703. 1996..Most individuals (87%) with the 20210 A allele are in the highest quartile of plasma prothrombin levels (> 1.15 U/mL). Elevated prothrombin itself also was found to be a risk factor for venous thrombosis...
- The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studiesMarc A Rodger
Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
PLoS Med 7:e1000292. 2010b>Factor V Leiden (FVL) and prothrombin gene mutation (PGM) are common inherited thrombophilias...
- Basic mechanisms and pathogenesis of venous thrombosisCharles T Esmon
Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, and Departments of Pathology and Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
Blood Rev 23:225-9. 2009..Among these, factor V Leiden, which renders factor Va resistant to activated protein C, is the most prevalent with approximately 5% of ..
- Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous ThromboembolismJ Emmerich
Hopital Europeen Georges Pompidou, Service de Medecine Vasculaire, Centre Claude Bernard et Laboratoire d Hémostase, Paris, France
Thromb Haemost 86:809-16. 2001b>Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors involved in venous thromboembolism (VTE)...
- Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2Bin Zhang
Life Sciences Institute, Department of Internal Medicine, 210 Washtenaw Ave, Ann Arbor, MI 48109 0650, USA
Blood 107:1903-7. 2006Mutations in LMAN1 (ERGIC-53) or MCFD2 cause combined deficiency of factor V and factor VIII (F5F8D)...
- Severe venous thromboembolism in a young man with Klinefelter's syndrome and heterozygosis for both G20210A prothrombin and factor V Leiden mutationsMario Lapecorella
Centro Emostasi e Trombosi, Dipartimento di Clinica Medica, Immunologia e Malattie Infettive MIDIM, University of Bari School of Medicine, Italy
Blood Coagul Fibrinolysis 14:95-8. 2003..Further examinations also showed a double heterozygosis for G20210A prothrombin and factor V Leiden mutations...
- Theoretical and experimental study of the D2194G mutation in the C2 domain of coagulation factor VM A Miteva
French National Institute of Health and Medical Research INSERM U428, University Paris V, 75006 Paris, France
Biophys J 86:488-98. 2004Coagulation factor V (FV) is a large plasma glycoprotein with functions in both the pro- and anticoagulant pathways...
- Risk assessment for recurrent venous thrombosisPaul Alexander Kyrle
Department of Medicine I, Medical University of Vienna, Vienna, Austria
Lancet 376:2032-9. 2010..Analysis of preliminary data suggests that risk assessment can also be refined through integration of prothrombotic coagulation changes and clinical risk factors...
- The limits of simulation of the clotting systemR Wagenvoord
Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, Netherlands
J Thromb Haemost 4:1331-8. 2006..To investigate in how far successful simulation of a thrombin generation (TG) curve gives information about the underlying biochemical reaction mechanism...
- Electrochemical genosensor based on colloidal gold nanoparticles for the detection of Factor V Leiden mutation using disposable pencil graphite electrodesMehmet Ozsoz
Department of Analytical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey
Anal Chem 75:2181-7. 2003Electrochemical genosensors for the detection of the Factor V Leiden mutation from polymerase chain reaction (PCR) amplicons using the oxidation signal of colloidal gold (Au) is described...
- Adjuvant immunization induces high levels of pathogenic antiphospholipid antibodies in genetically prone mice: another facet of the ASIA syndromeA Katzav
Department of Neurology and Sagol Center for Neurosciences, Sheba Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Lupus 21:210-6. 2012..Patients with both antiphospholipid antibodies (aPL) and the genetic coagulopathy factor V Leiden (FVL) are frequently found...
- Combined Factor V and Factor VIII DeficiencyMarta Spreafico
A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, 20122 Milan, Italy
Semin Thromb Hemost 35:390-9. 2009Combined deficiency of factor V (FV) and factor VIII (FVIII) (F5F8D, or FV+FVIII) is a autosomal recessive bleeding disorder caused by mutations in genes encoding two components of the endoplasmic reticulum (ER)-Golgi intermediate ..
- Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in 200 healthy JordaniansSuhair S Eid
Molecular Laboratory, King Hussein Medical Centre, Jordan
Clin Lab Sci 17:200-2. 2004..In order to estimate the frequency of the factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in the Jordanian population, we screened 200 healthy ..
- Prevalence of factor V leiden, factor V cambridge, factor II G20210A and methylenetetrahydrofolate reductase C677T mutations in healthy and thrombophilic Serbian populationsV Djordjevic
Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia and Montenegro
Acta Haematol 112:227-9. 2004
- Prevalence of factor V Leiden, prothrombin and methylene tetrahydrofolate reductase mutations in women with adverse pregnancy outcomes in LebanonLaila F Zahed
Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Lebanon
Am J Obstet Gynecol 195:1114-8. 2006The purpose of this study was to determine the prevalence of factor V Leiden, prothrombin, and methylene tetrahydrofolate reductase gene mutations in women with adverse pregnancy outcome compared with women who had uneventful pregnancies.
- Prevalence of antiphospholipid antibodies, factor V G1691A (Leiden) and prothrombin G20210A mutations in early and late recurrent pregnancy lossNabil Mtiraoui
Research Unit of Haematological and Autoimmune Diseases, Faculty of Pharmacy, Monastir, Center University, Tunisia
Eur J Obstet Gynecol Reprod Biol 119:164-70. 2005..We assessed the prevalence of inherited (FV-Leiden and PRT G20210A), and acquired (anti-PL antibodies) risk factors among habitual aborters in Tunisia...
- Factor V Leiden and prothrombin gene G20210A mutations are uncommon in portal vein thrombosis in IndiaSanjay Sharma
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
Indian J Gastroenterol 25:236-9. 2006..The cause of thrombosis in these patients remains unclear. We studied the frequency of mutations in genes for coagulation factors V and II (prothrombin) in 61 Indian patients with PVT and 49 healthy control subjects...
- Prevalence of factor V Leiden in patients with myocardial infarction and normal coronary angiographyJ Mansourati
Cardiology Department of Brest, North Hospital of Saint Etienne, France
Thromb Haemost 83:822-5. 2000b>Factor V Leiden is associated with an increased risk of venous thrombosis and myocardial infarction in young women, but not in men in this latter case...
- Prevalence of factor V Leiden mutation and other hereditary thrombophilic factors in Egyptian children with portal vein thrombosis: results of a single-center case-control studyHanaa El-Karaksy
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
Ann Hematol 83:712-5. 2004..Our aim was to assess the prevalence of factor V Leiden mutation and other thrombophilic factors as risk factors in the development of PVT in the pediatric age ..
- Absence of factor V Leiden mutation and low prothrombin G 20210 A mutation prevalence in a healthy Moroccan populationFlorence Mathonnet
Thromb Haemost 88:1073-4. 2002
- Factor V Leiden G1691A and prothrombin G20210A mutations are common in TunisiaC Frere
J Thromb Haemost 1:2451-2. 2003
- Prevalence of angiotensin-converting enzyme, methylenetetrahydrofolate reductase, Factor V Leiden, prothrombin and apolipoprotein E gene polymorphisms in MoroccoThierry Paluku They-They
Laboratoire de Génétique Médicale et Pathologie Moléculaire LGPM, Faculté de Médecine et de Pharmacie Casablanca, 19 rue Tarik Ibn Ziad, Casablanca, Morocco
Ann Hum Biol 37:767-77. 2010..These genetic factors are involved in several pathways affecting blood pressure regulation, blood coagulation, homocysteine and lipid metabolisms...
- Deep venous thrombosis and thrombophilic mutations in western Iran: association with factor V LeidenZohreh Rahimi
Medical Biology Research Center, Kermanshah University of Medical Sciences, Iran
Blood Coagul Fibrinolysis 21:385-8. 2010The aim of present study was to investigate the prevalence of factor V Leiden (FVL) c.1691G>A, prothrombin g.20210G>A and methylenetetrahydrofolate reductase (MTHFR) c...
- Allelic frequency of the factor V Leiden mutation and of the pro-thrombin gene 20210A mutation in healthy Tunisian populationLobna Bouaziz
Thromb Haemost 91:824-5. 2004
- Prevalence of factor V Leiden and prothrombin G20210A mutation in a large French population selected for nonthrombotic history: geographical and age distributionElisabeth Mazoyer
Hématologie biologique, Hopital Lariboisiere, Paris, France
Blood Coagul Fibrinolysis 20:503-10. 2009..These polymorphisms confer a very mild hypercoagulable state as shown by the limited increased in basal D-dimers in mutated FV-G1691A populations and only a trend that does not reach statistical significance for FII-G20210A population...
- Prevalence of two thrombophilia predisposing mutations: factor V G1691A (R506Q; Leiden) and prothrombin G20210A, among healthy LebaneseHala Tamim
Thromb Haemost 88:691-2. 2002
- Prevalence and association of the factor V Leiden and prothrombin G20210A in healthy subjects and patients with venous thromboembolismD Coen
Clinical Institute of Laboratory Diagnostics, Zagreb University Hospital Center, Zagreb, Croatia
Croat Med J 42:488-92. 2001To determine the prevalences of factor V Leiden and the G20210A mutation in the prothrombin gene (PT20210A) and the frequency of their association in healthy subjects and in patients with venous thromboembolism (VTE).
- High incidence of factor V Leiden and prothrombin G20210A in healthy southern ItaliansGianluca Sottilotta
Centro Emofilia, Servizio Emostasi e Trombosi, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
Clin Appl Thromb Hemost 15:356-9. 2009b>Factor V Leiden (FVL) and G20210 prothrombin (FII G20210A) mutations are risk factors for thromboembolism...
- Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysisGeorge Kovalevsky
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, USA
Arch Intern Med 164:558-63. 2004..Recently, thrombophilias have been implicated as a possible cause. Factor V Leiden (FVL) and prothrombin gene (G20210A) mutations are the most common types of hereditary thrombophilias, but ..
- Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysisT Dudding
Hunter Genetics, Hunter New England Health Service, NSW, Australia
J Thromb Haemost 6:1869-75. 2008..have suggested that there is a relationship between poor pregnancy outcomes and two polymorphisms, one in the factor V gene, the 1691G to A change (rs6025) located on chromosome 1q23 (factor V Leiden, FVL), and the other in the ..
- Malignancies, prothrombotic mutations, and the risk of venous thrombosisJeanet W Blom
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
JAMA 293:715-22. 2005..Venous thrombosis is a common complication in patients with cancer, leading to additional morbidity and compromising quality of life...
- Primary habitual abortions are associated with high frequency of factor V Leiden mutationM L Wramsby
Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
Fertil Steril 74:987-91. 2000To analyze the prevalence of the mutation G1691A in factor V gene (Leiden mutation), of mutation C677T in the methylenetetrahydrofolate reductase (MTHFR) gene, and of polymorphism in G20210A in the prothrombin gene in women with recurrent ..
- Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosisP Simioni
Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
Blood 96:3329-33. 2000Carriers of a mutation in the prothrombin (clotting factor II) or factor V gene have a 2- to 4-fold greater risk for venous thromboembolism than subjects without the mutations...
- The thrombophilias: well-defined risk factors with uncertain therapeutic implicationsK A Bauer
From Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts, USA
Ann Intern Med 135:367-73. 2001Discovery of the factor V Leiden and prothrombin G20210A mutations has greatly increased the percentage of patients in whom venous thrombosis can be attributed to hereditary thrombophilia...
- Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V LeidenS Eichinger
Department of Internal Medicine I, University Vienna, Austria
Thromb Haemost 82:1232-6. 1999..The risk of venous thrombosis is higher in pregnant women with factor V Leiden (FVL) than in those with wildtype factor V...
- Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic reviewJodi B Segal
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
JAMA 301:2472-85. 2009..Testing for genetic risks for venous thromboembolism (VTE) is common, but the safety and utility of such testing need review...
- Factor V Leiden and prothrombin gene mutation may predispose to paradoxical embolism in subjects with patent foramen ovaleVesa Karttunen
Department of Neurology, Oulu University Central Hospital, Box 25, FIN 90029 Oulu, Finland
Blood Coagul Fibrinolysis 14:261-8. 2003..We assessed the occurrence of several prothrombotic states (factor V Leiden, prothrombin G20210A, deficiencies in protein S, protein C and antithrombin, lupus anticoagulant, ..
- Prothrombotic mutations as risk factors for cryptogenic ischemic cerebrovascular events in young subjects with patent foramen ovaleNicoletta Botto
CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
Stroke 38:2070-3. 2007..We evaluated the prevalence of the 2 most common genetic risk factors for thromboembolism, factor V Leiden (G1691A) and prothrombin G20210A, in young PFO patients who were referred for percutaneous transcatheter ..
- Distinct association of factor V-Leiden and prothrombin G20210A mutations with deep venous thrombosis in Tunisia and LebanonLobna Bouaziz-Borgi
Faculty of Pharmacy, University of Monastir, Tunisia
Am J Hematol 81:641-3. 2006b>Factor V G1691A (FV-Leiden) and prothrombin (PRT) G20210A single nucleotide polymorphisms (SNPs) were associated with venous thrombosis among Caucasians...
- Primer-engineered multiplex PCR-RFLP for detection of MTHFR C677T, prothrombin G20210A and factor V Leiden mutationsVedat Koksal
Burc Molecular Diagnostic Laboratory, Istanbul, Turkey
Exp Mol Pathol 83:1-3. 2007Single-nucleotide polymorphisms in the genes that code for coagulation factors V (factor V Leiden) and II (prothrombin, G20210A), as well as the methylenetetrahydrofolate reductase (MTHFR, C677T) gene, have been implicated in the majority ..
- Can Factor V Leiden and prothrombin G20210A testing in women with recurrent pregnancy loss result in improved pregnancy outcomes?: Results from a targeted evidence-based reviewLinda A Bradley
Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Genet Med 14:39-50. 2012Women with recurrent pregnancy loss are offered Factor V Leiden (F5) and/or prothrombin G20210A (F2) testing to identify candidates for anticoagulation to improve outcomes...
- Livedoid vasculopathy in a patient with factor V mutation (Leiden)T Biedermann
Department of Dermatology, Ludwig Maximilians University, Munich, Germany
J Cutan Pathol 27:410-2. 2000..For these forms, an unknown vaso-occlusive or thrombogenic process has been accused to play a role. Thus, a patient with livedoid vasculopathy was examined for different parameters which can be involved in coagulopathies...
- Broadening the factor V Leiden paradox: pulmonary embolism and deep-vein thrombosis as 2 sides of the spectrumKirsten van Langevelde
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Blood 120:933-46. 2012..A well-known example is the factor V Leiden (FVL) paradox: the FVL mutation poses a clearly higher risk for deep-vein thrombosis (DVT) than for ..
- Increased titer of anti-beta2-glycoprotein I IgG antibody among factor V Leiden carriers during oral contraceptive useR Poka
Department of Obstetrics and Gynecology, University of Debrecen, Medical and Health Science Cente, Nagyerdei krt 98, 4012 Debrecen, Hungary
Contraception 69:27-30. 2004The risk of thromboembolism during oral contraceptive (OC) use is increased among factor V Leiden (FVL) carriers compared to women with wild-type genotype of the gene for coagulation factor V (FV)...
- The R306G and R506Q mutations in coagulation Factor V reveals additional cleavage sites for Activated Protein C in the R313-R321 region and at R505Richard J Dirven
Einthoven Laboratory for Experimental Vascular Medicine, Dept of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
Thromb Res 125:444-50. 2010The procoagulant function of activated factor V (FVa) is inhibited by activated Protein C (APC) through proteolytic cleavages at R306, R506 and R679...
- A male adolescent with left iliac thrombophlebitis and heterozygosity for factor V Leiden mutationAmy E Lovejoy
Division of Hematology Oncology, Rady Children s Hospital, San Diego, CA 92123, USA
J Pediatr Surg 44:1640-2. 2009..J Intern Med. 2002;252:276-280). Secondly, resistance to activated protein C as a result of factor V Leiden is associated with thromboembolic disease at an early age (Price DT, Ridker PM. Ann Intern Med...
- Factor V Leiden and prothrombin G20210A mutations and the risk of atherothrombotic events in systemic lupus erythematosusRudolf Pullmann
Medical Clinic II, Jessenius Medical Faculty, Martin Faculty Hospital, Martin, Slovakia
Clin Appl Thromb Hemost 10:233-8. 2004..SLE) remains to be determined, the most common genetic prothrombotic factors, prothrombin G20210A and factor V Leiden mutations, were studied...
- Role of mesangial Factor V expression in crescent formation in rat experimental mesangioproliferative glomerulonephritisTakahiko Ono
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
J Pathol 204:229-38. 2004..b>Factor V is a membrane-bound potent cofactor for the conversion of prothrombin to thrombin by Factor Xa...
- Endogenous factor V synthesis in megakaryocytes contributes negligibly to the platelet factor V poolM Christella L G D Thomassen
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Haematologica 88:1150-6. 2003Coagulation factor V (FV) is distributed between two pools: 80% circulates in plasma and 20% is stored in platelets. The aim of the study was to determine the origin of platelet FV.
- The Factor V Leiden mutation is associated with a higher blood haemoglobin concentration in women below 50 of the Malmö Thrombophilia Study (MATS)Nazim Isma
Malmö Centre for Thrombosis and Haemostasis, Malmo, Sweden
J Thromb Thrombolysis 28:255-8. 2009....
- Factor II G20210A and factor V G1691A gene mutations and peripheral arterial occlusive diseaseW Renner
Department of Medicine, Karl Franzens University, Graz, Austria
Thromb Haemost 83:20-2. 2000G to A mutations at positions 20210 of the prothrombin gene (F2) and 1691 of the factor V gene (F5) are established risk factors for venous thrombosis...
- Factor V gene A4070G mutation and the risk of cerebral veno-sinus thrombosis occurring during puerperiumNagaraja Dindagur
Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, Karnataka, India
Thromb Res 119:497-500. 2007..A recently identified polymorphism in factor V gene, A4070G (R2 allele), has been reported as a risk factor for venous thrombosis in some studies...
- The role of factor V Leiden and prothrombin G20210A mutations in sudden sensorineural hearing lossKemal Gorur
Department of Otorhinolaryngology, University of Mersin School of Medicine, Mersin, Turkey
Otol Neurotol 26:599-601. 2005To investigate the incidence of factor V Leiden and prothrombin G20210A in sudden sensorineural hearing loss patients.
- Variable plasma levels of Factor V Leiden correlate with circulating platelet microparticles in carriers of Factor V LeidenLisa F Lincz
Hunter Haematology Research Group, Calvary Mater Newcastle Hospital, NSW, Australia
Thromb Res 129:192-6. 2012Inheritance of Factor V Leiden (FVL) is associated with an increased but variable level of risk for thrombosis. We have previously shown that FVL heterozygotes have elevated levels of circulating pro-coagulant microparticles (MP)...
- Factor V deficiency: a concise reviewJ N Huang
Department of Pediatrics, UCSF Children s Hospital, San Francisco, California 94143 0106, USA
Haemophilia 14:1164-9. 2008b>Factor V (FV; proaccelerin or labile factor) is the plasma cofactor for the prothrombinase complex that activates prothrombin to thrombin...
- Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcersY Gaber
Department of Dermatology, Medical University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
Br J Dermatol 144:546-8. 2001..Activated protein C (APC) resistance is the most frequently diagnosed heritable thrombophilic defect predisposing to thrombosis...
- Gene analysis and prenatal diagnosis for two families of congenital factor V deficiencyL Cao
The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China
Haemophilia 17:65-9. 2011..two families in which the probands had severe bleeding tendency and showed low plasma levels of coagulation factor V (FV) antigen and activity...
- Systemic-to-pulmonary artery shunt thrombosis in a neonate with factor V Leiden mutationJanet M Simsic
Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann Thorac Surg 74:2179-81. 2002..Hematologic evaluation revealed heterozygous factor V Leiden mutation...
- Factor V Leiden, prothrombin G20210A, and protein C mutation frequency in Turkish venous thrombosis patientsJulide Altinisik
Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
Clin Appl Thromb Hemost 14:415-20. 2008..inherited polymorphisms are associated with risk of venous thrombosis, including mutation at codon 506 of the factor V gene, mutation at position 20210 of the prothrombin gene, and mutations in the protein C gene...
- The factor V Leiden mutation, high factor VIII, and high plasminogen activator inhibitor activity: etiologies for sporadic miscarriageCharles J Glueck
Cholesterol Center, Department of Medicine, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
Metabolism 54:1345-9. 2005We hypothesized that the thrombophilic G1691A factor V Leiden gene mutation was a common significant cause of sporadic first trimester miscarriage...
- The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysisTracy E Dudding
Hunter Genetics, PO Box 84 Waratah, 2289, NSW, Australia
Thromb Haemost 91:700-11. 2004The conclusions of studies to date which evaluate a possible association between factor V Leiden and adverse pregnancy outcome have been conflicting. This study was undertaken to further investigate this association...
- Deep venous thrombosis caused by congenital malformation of the inferior vena cava and heterozygous factor V leiden presenting as venous claudicationGary Fass
Department of Emergency, Brugmann University Hospital, Brussels, Belgium
Clin Appl Thromb Hemost 15:591-5. 2009..thrombosis of the lower limbs caused by hypoplasia of the inferior vena cava in combination with heterozygous factor V Leiden is presented. Both anomalies were found when the patient complained of venous claudication in both thighs...
- Vascular behcet and mutations in thrombogenic genes: methylene tetrahydrofolate reductase, factor V, and prothrombinEfrat Dagan
Department of Nursing, University of Haifa, Haifa, Israel
Genet Test Mol Biomarkers 16:30-5. 2012..The common inherited gene defects, factor V (FV) 1691A (Leiden), methylene tetrahydrofolate reductase (MTHFR) 677T, and prothrombin 20210A, are known risk ..
- Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary proteinTim J Schuijt
Center for Experimental and Molecular Medicine, University of Amsterdam, Meibergdreef 9, Room L01 145, 1105 AZ, Amsterdam, The Netherlands
Circulation 128:254-66. 2013..The current paradigm assumes that FV activation is initiated by limited proteolysis by traces of (meizo) thrombin...
- Factor V Leiden mutation in Sneddon syndromeR Besnier
Service de Medecine Interne, Hopital de la Pitie, Paris, France
Lupus 12:406-8. 2003..Its pathophysiology is still controversial. The aim of this study was to evaluate the prevalence of factor V Leiden mutation in consecutive patients referred for SNS according to antiphospholipid antibodies (aPL) status...
- The role of platelets in venous thrombosis: a patient with Glanzmann's thrombasthenia and a factor V Leiden mutation suffering from deep venous thrombosisH ten Cate
J Thromb Haemost 1:394-5. 2003
- Circulating microparticles are elevated in carriers of factor V LeidenAnoop K Enjeti
Hunter Haematology Research Group, Calvary Mater Newcastle, Edith Street, Waratah, NSW 2298, Australia
Thromb Res 126:250-3. 2010..This study was carried out to evaluate if increased numbers or procoagulant potential of circulating MP contribute to the heterogeneity in occurrence of thrombosis in heterozygotes carrying Factor V Leiden (FVL) mutation.
- Interaction between factor V Leiden and serum LDL cholesterol increases the risk of atherosclerosisHenry Volzke
Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Walther Rathenau Str 48, D 17487 Greifswald, Germany
Atherosclerosis 180:341-7. 2005We investigated the association between the factor V Leiden gene variant and carotid atherosclerosis in a cross-sectional study and explored possible associations between this gene variant and coronary artery disease (CAD) in a case-..
- Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenzaM Schouten
Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
Eur Respir J 36:1346-54. 2010..Knowledge on coagulation activation in influenza infection is limited. The factor V Leiden (FVL) mutation is possibly subject to positive selection pressure...
- Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathyHongjie Wang
Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
Blood 117:5231-42. 2011..The high prevalence of the prothrombotic factor V Leiden (FVL) mutation in whites has been attributed to a positive selection pressure (eg, resulting from reduced ..
- Combined factor V Leiden and prothrombin genotyping in patients presenting with thromboembolic episodesJ A Friedline
Kennewick, Wash, USA
Arch Pathol Lab Med 125:105-11. 2001Several genetic defects are associated with increased risk of venous thrombosis. The factor V Leiden (FVL) and prothrombin G20210A mutations are the most frequent causes of inherited thrombophilia.
- Central retinal artery occlusion in a patient homozygous for factor V LeidenJ Larsson
Department of Ophthalmology, Lund University Hospital, Lund, Sweden
Am J Ophthalmol 129:816-7. 2000To report an association between central retinal artery occlusion and homozygosity for factor V Leiden.
- No excess of factor V:Q506 genotype but high prevalence of anticardiolipin antibodies without antiendothelial cell antibodies in retinal vein occlusion in young patientsJ A Scott
Department of Ophthalmology, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, UK
Ophthalmologica 215:217-21. 2001b>Factor V:Q506 (factor V Leiden) is associated with venous thrombosis and has been reported to be a risk factor for retinal vein occlusion (RVO)...
- Factor V Leiden and the etiology of inflammatory bowel diseaseC Arnold Spek
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Thromb Haemost 98:670-3. 2007..We therefore conclude that the FV Leiden allele has no effect in murine colitis and we thus question the importance of activated blood coagulation in the etiology or pathogenesis of IBD...
- Factor V Leiden is associated with more distal location of deep vein thrombosis of the legM V Huisman
J Thromb Haemost 6:544-5. 2008
- A mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in TunisiaAvichai Segal
Thrombosis and Hemostasis Research Institute, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
Blood Coagul Fibrinolysis 15:99-102. 2004Combined deficiency of factor V and factor VIII is a rare autosomal recessive bleeding disorder that is caused by mutations in the LMAN1 or MCFD2 genes...
- Location and extent of deep vein thrombosis in patients with and without FV:R 506Q mutationO Björgell
Department of Diagnostic Radiology, University of Lund, Malmo University Hospital, Malmo, Sweden
Thromb Haemost 83:648-51. 2000..0001). Our findings provide the basis of a detailed phlebographic description and for the first time, to our best knowledge, shows a specific phlebographic pattern that may be linked to an inherited hypercoagulable state...
- The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature diseaseP M Mannucci
Centro Emofilia e Trombosi A Bianchi Bonomi, Scientific Direction, IRCCS Fondazione Cà Granda Ospedale Maggiore, Universita degli Studi di Milano, Milan, Italy
J Thromb Haemost 8:2116-21. 2010....
- Development of factor V and thrombin inhibitors in children following bovine thrombin exposure during cardiac surgery: a report of three casesLisa Bomgaars
Department of Pediatrics, Hematology Oncology Section, Baylor College of Medicine, Houston, TX 77030, USA
Congenit Heart Dis 5:303-8. 2010b>Factor V and thrombin inhibitors may develop following exposure to bovine thrombin preparations...
- Renin-angiotensin system and haemostasis gene polymorphisms and outcome after coronary artery bypass graft surgeryHenry Volzke
Department of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Walther Rathenau Str 48, D 17487 Greifswald, Germany
Int J Cardiol 98:133-9. 2005..system (angiotensinogen 235 M/T, angiotensin II type 1 receptor 1166 A/C) or the clotting system (glycoprotein IIIa PlA1/PlA2 and factor V Leiden 1691 G/A) are associated with the outcome after coronary artery bypass grafting.
- Analysis of the factor V Leiden mutation using the READIT AssayR B Rhodes
University of Minnesota, Minneapolis, MN, USA
Mol Diagn 6:55-61. 2001..We show the application of a novel SNP scoring tool for analysis of the factor V Leiden mutation. METHODS AND RESULTS: We have developed a novel method for analyzing SNPs...
- Prevalence of resistance against activated protein C resulting from factor V Leiden is significantly increased in myocardial infarction: investigation of 507 patients with myocardial infarctionKatharina Middendorf
Medical Clinic I, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany
Am Heart J 147:897-904. 2004A point mutation in the gene encoding coagulation factor V is a cause of resistance against activated protein C. The presence of factor V Leiden is linked to 50% of congenital defects causing venous thrombosis...
- Association of factor V gene polymorphisms (Leiden; Cambridge; Hong Kong and HR2 haplotype) with recurrent idiopathic pregnancy loss in Tunisia. A case-control studyWalid Zammiti
Research Unit of Haematological and Autoimmune Diseases, Faculty of Pharmacy, Monastir, Center University, Tunisia
Thromb Haemost 95:612-7. 2006..We performed a case-control study on the association between thrombosis-related polymorphisms in the factor V (FV) gene (Leiden, Cambridge, Hong Kong; HR2 haplotype) and idiopathic recurrent pregnancy loss (RPL) in Tunisian ..
- Factor V Leiden mutation in venous thrombosis in southeast TurkeySevgi Kalkanli
Department of Medical Genetic Biology, University of Dicle, Diyarbakir, Turkey
Angiology 57:193-6. 2006..b>Factor V Leiden mutation (G1691A) (FVL) is the most common risk factor in venous thrombosis...
- Arterial thrombosis associated with heterozygous factor V Leiden disorder, hyperhomocysteinemia, and peripheral arterial disease: importance of synergistic factorsCameron Page
Department of Surgery, VA Connecticut Healthcare System, Yale University School of Medicine, New Haven, CT 06519, USA
J Vasc Surg 42:1014-8. 2005A 47-year-old man with heterozygous factor V Leiden disorder and intermittent hyperhomocysteinemia developed spontaneous acute popliteal artery thrombosis. Homocysteine levels were above normal limits at presentation...
- Population genetics of factor V Leiden in EuropeG Lucotte
International Institute of Anthropology, 1 place d Iéna, Paris 16ème, France
Blood Cells Mol Dis 27:362-7. 2001..originating from 26 geographically defined populations in Europe and neighboring countries for the presence of factor V Leiden, an important genetic risk factor in venous thromboembolism...
- Prevalence of factor V Leiden and G6PD 1311 silent mutations in Dalmatian populationVedrana Cikes
Laboratory for Molecular Biology, University of Split, School of Medicine, Split, Croatia
Arch Med Res 35:546-8. 2004b>Factor V Leiden has been described as a common genetic risk factor for venous thromboembolism. The geographic distribution of this abnormality varies greatly, being high in Europe and almost absent in Asia and Africa...
- Prevalence of factor V Leiden and prothrombin G20210A gene mutationAhmet Irdem
Department of Pediatrics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
Saudi Med J 26:580-3. 2005To determine the prevalence of factor V Leiden (FVL) and prothrombin gene (PG) 20210A mutations in patients who attended the outpatient clinic and do not have a family history of thrombosis.
- An Arab selective gradient in the distribution of factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677TG Ameen
J Thromb Haemost 3:2126-7. 2005
- Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR G677A among 594 thrombotic Jordanian patientsSuhair S Eid
King Hussein Medical Center, Princess Iman Research Center for Laboratory Sciences, Amman, Jordan
Blood Coagul Fibrinolysis 16:417-21. 2005..In order to estimate the frequency of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in Jordanian thrombotic patients, we studied 594 patients ..
- Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial protein C receptor (EPCR) gene on the risk of venous thromboembolism in carriers of factor V LeidenPilar Medina
Research Center, La Fe University Hospital, Valencia, Spain
Thromb Haemost 94:389-94. 2005..The objective of this study was to assess whether these polymorphisms modify the risk of VTE in carriers of factor V (FV) Leiden...
- The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or bothI Martinelli
Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, University of Milan, Italy
Br J Haematol 111:1223-9. 2000b>Factor V Leiden and the G20210A mutation in the prothrombin gene are the most frequent abnormalities associated with venous thromboembolism. It is unknown whether the risks due to the presence of either mutation are of the same magnitude...
- Factor V Leiden thrombophiliaJody Lynn Kujovich
Northwest Cancer Specialists, Portland, OR 97227, USA
Genet Med 13:1-16. 2011b>Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to activated Protein C and an increased risk for venous thromboembolism...
- Race differences in the prevalence of the factor V Leiden mutation in Kuwaiti nationalsAli A Dashti
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, P O Box 31470, 90805, Sulaibekhat, Kuwait
Mol Biol Rep 38:3623-8. 2011b>Factor V Leiden mutation (FVL; G1691A) is an established risk factor for venous thromboembolic disorders. FVL was reported with high prevalence in Caucasians (1-15%) but was absent in non-Caucasians like Africans and Asians...
- Decision analysis model of prolonged oral anticoagulant treatment in factor V Leiden carriers with first episode of deep vein thrombosisF P Sarasin
Medical Clinics, Hospital Cantonal, University of Geneva Medical School, Switzerland
BMJ 316:95-9. 1998..treatment extended beyond 3 months after a first episode of deep vein thrombosis in patients who carry factor V Leiden mutation...
- MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR VThomas Ortel; Fiscal Year: 2010..A membrane binding site was localized to the factor V C2 domain and the structures of two crystal forms of this domain have been elucidated...
- MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR VWILLIAM KANE; Fiscal Year: 2009..A membrane binding site was localized to the factor V C2 domain and the structures of two crystal forms of this domain have been elucidated...
- NICHD Maternal Fetal Medicine Units NetworkBrian Mercer; Fiscal Year: 2007..fetal pulse oximetry in labor, treatment of mild gestational diabetes, vaginal birth after cesarean, Factor V Leiden mutation carriage)...
- FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATIONPaul E Bock; Fiscal Year: 2010b>Factor V plays a pivotal role in hemostasis, and in the pathology of venous thrombosis...
- FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATIONPaul Bock; Fiscal Year: 2007b>Factor V plays a pivotal role in hemostasis, and in the pathology of venous thrombosis...
- MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR VWILLIAM KANE; Fiscal Year: 2004..that two tryptophans located in a mobile solvent exposed loop play a critical role in high affinity binding of factor V to phospholipid membranes containing low concentrations of phosphatidylserine...
- MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR VWILLIAM KANE; Fiscal Year: 2007..A membrane binding site was localized to the factor V C2 domain and the structures of two crystal forms of this domain have been elucidated...
- MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR VWILLIAM KANE; Fiscal Year: 1993DESCRIPTION: (Adapted from the investigator's abstract). Factor V is a protein cofactor that is essential for the prothrombinase complex. This complex consists of factor Va, factor Xa, calcium, and a phospholipid surface...
- Surrogate markers for Severe Pulmonary EmbolismJEFFREY KLINE; Fiscal Year: 2005..if patients with PE complicated by an adverse outcome are more likely to have antiphospholipid antibodies, or factor V Leiden G1691A, prothrombin G20210A, methylenetetrahydrofolate reductase C677T mutations, or low red blood cell ..
- Epidemiologic Study of Placental AbruptionCande Ananth; Fiscal Year: 2006..from which DNA will be extracted and assayed for genetic mutations and polymorphisms, including those for factor V Leiden (1691G yields A), prothrombin gene (20210G yields A), the 677C yields T and 1298A yields C polymorphisms ..
- Functional Domains of Coagulation Factor VMichael Kalafatis; Fiscal Year: 2007..The procofactor, factor V, does not participate in prothrombinase...
- Thrombin Formation InhibitorsJames Phillips; Fiscal Year: 2004..Generation of DVT is strongly correlated with the function of factor V, a protein cofactor for prothrombinase...
- MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISMBruce Psaty; Fiscal Year: 2001DESCRIPTION: (Adapted from Investigator's Abstract) Epidemiologic studies have identified Factor V Leiden as the most common cause of heritable thrombophilia a prothrombotic mutation associated with a 5 to 7-fold increase in the risk of ..
- PRIMARY STRUCTURE OF PROTHROMBINKenneth Mann; Fiscal Year: 2003b>Factor V is a central participant in the blood clotting process...
- Processed Defining Megakaryocyte Endocytosis of Factor VPAULA TRACY; Fiscal Year: 2005..the rate of thrombin generation, the physiologic effect being demonstrated by the severe hemorrhage observed in factor V deficiency...
- Discovery of antivirals against vaccinia and smallpoxRobert Ricciardi; Fiscal Year: 2003..The approach may help deliver the 'just-in-time' need for reagents to combat a smallpox bioterrorism threat. ..
- COMMON VARIANTS IN CANDIDATE GENES AND PREMATURE MI RISKStephen Schwartz; Fiscal Year: 2001..Those data show that common polymorphisms in genes coding for two clotting factors, coagulation Factor V and coagulation Factor II, are risk factors for MI only among cigarette smokers in this sample...