factor v

Summary

Summary: Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.

Top Publications

  1. ncbi The mechanism of inactivation of human factor V and human factor Va by activated protein C
    M Kalafatis
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington 05405 0068
    J Biol Chem 269:31869-80. 1994
  2. ncbi Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterized
    Marten Steen
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Blood 102:1316-22. 2003
  3. doi Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study
    Leena M Hiltunen
    Department of Hemostasis, Finnish Red Cross Blood Service, Helsinki, Finland
    Thromb Res 124:167-73. 2009
  4. ncbi Varied prevalence of factor V G1691A (Leiden) and prothrombin G20210A single nucleotide polymorphisms among Arabs
    Wassim Y Almawi
    Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
    J Thromb Thrombolysis 20:163-8. 2005
  5. ncbi Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    JAMA 277:1305-7. 1997
  6. ncbi Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study
    E R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:632-7. 2008
  7. ncbi A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
    S R Poort
    Hemostasis and Thrombosis Research Center, Leiden University Hospital, The Netherlands
    Blood 88:3698-703. 1996
  8. pmc The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS Med 7:e1000292. 2010
  9. pmc Basic mechanisms and pathogenesis of venous thrombosis
    Charles T Esmon
    Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, and Departments of Pathology and Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
    Blood Rev 23:225-9. 2009
  10. ncbi Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism
    J Emmerich
    Hopital Europeen Georges Pompidou, Service de Medecine Vasculaire, Centre Claude Bernard et Laboratoire d Hémostase, Paris, France
    Thromb Haemost 86:809-16. 2001

Research Grants

  1. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
  2. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 2009
  3. NICHD Maternal Fetal Medicine Units Network
    Brian Mercer; Fiscal Year: 2009
  4. NICHD Maternal Fetal Medicine Units Network
    Brian M Mercer; Fiscal Year: 2011
  5. NICHD Maternal Fetal Medicine Units Network
    Brian Mercer; Fiscal Year: 2006
  6. NICHD Maternal Fetal Medicine Units Network
    Brian Mercer; Fiscal Year: 2007
  7. NICHD Maternal Fetal Medicine Units Network
    Brian M Mercer; Fiscal Year: 2010
  8. METAL-DEPENDENT COMPLEXES IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 1980
  9. Role of PAI-1 in Venous THrombosis
    Thomas Wakefield; Fiscal Year: 2009
  10. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul E Bock; Fiscal Year: 2010

Detail Information

Publications285 found, 100 shown here

  1. ncbi The mechanism of inactivation of human factor V and human factor Va by activated protein C
    M Kalafatis
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington 05405 0068
    J Biol Chem 269:31869-80. 1994
    The cleavage of human factor V and human factor Va by human activated protein C (APC) was analyzed in the absence and presence of phospholipid vesicles containing 75% phosphatidylcholine (PC) and 25% phosphatidylserine (PS)...
  2. ncbi Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterized
    Marten Steen
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, The Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Blood 102:1316-22. 2003
    b>Factor V (FV) deficiency, also known as parahemophilia, is a rare bleeding disorder. Herein we investigate the first reported missense mutation associated with FV deficiency, Ala221Val, assigned as FV New Brunswick...
  3. doi Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study
    Leena M Hiltunen
    Department of Hemostasis, Finnish Red Cross Blood Service, Helsinki, Finland
    Thromb Res 124:167-73. 2009
    ..ABO blood group has been associated with thrombotic disorders and pre-eclampsia. We assessed ABO blood group, seven thrombophilia associated polymorphisms, and anti-beta2-glycoprotein I antibodies as risk factors for pre-eclampsia...
  4. ncbi Varied prevalence of factor V G1691A (Leiden) and prothrombin G20210A single nucleotide polymorphisms among Arabs
    Wassim Y Almawi
    Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
    J Thromb Thrombolysis 20:163-8. 2005
    b>Factor V G1691A (FV-Leiden) and prothrombin (PRT) G20210A single nucleotide polymorphisms (SNPs) are major inherited risk factors of venous thromboembolism...
  5. ncbi Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    JAMA 277:1305-7. 1997
    To estimate ethnic-specific prevalence rates of factor V Leiden, an inherited defect of hemostasis associated with risk of venous thrombosis.
  6. ncbi Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study
    E R Pomp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:632-7. 2008
    ..Venous thrombosis is one of the leading causes of maternal morbidity and mortality...
  7. ncbi A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
    S R Poort
    Hemostasis and Thrombosis Research Center, Leiden University Hospital, The Netherlands
    Blood 88:3698-703. 1996
    ..Most individuals (87%) with the 20210 A allele are in the highest quartile of plasma prothrombin levels (> 1.15 U/mL). Elevated prothrombin itself also was found to be a risk factor for venous thrombosis...
  8. pmc The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS Med 7:e1000292. 2010
    b>Factor V Leiden (FVL) and prothrombin gene mutation (PGM) are common inherited thrombophilias...
  9. pmc Basic mechanisms and pathogenesis of venous thrombosis
    Charles T Esmon
    Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, and Departments of Pathology and Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
    Blood Rev 23:225-9. 2009
    ..Among these, factor V Leiden, which renders factor Va resistant to activated protein C, is the most prevalent with approximately 5% of ..
  10. ncbi Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism
    J Emmerich
    Hopital Europeen Georges Pompidou, Service de Medecine Vasculaire, Centre Claude Bernard et Laboratoire d Hémostase, Paris, France
    Thromb Haemost 86:809-16. 2001
    b>Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors involved in venous thromboembolism (VTE)...
  11. pmc Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2
    Bin Zhang
    Life Sciences Institute, Department of Internal Medicine, 210 Washtenaw Ave, Ann Arbor, MI 48109 0650, USA
    Blood 107:1903-7. 2006
    Mutations in LMAN1 (ERGIC-53) or MCFD2 cause combined deficiency of factor V and factor VIII (F5F8D)...
  12. ncbi Severe venous thromboembolism in a young man with Klinefelter's syndrome and heterozygosis for both G20210A prothrombin and factor V Leiden mutations
    Mario Lapecorella
    Centro Emostasi e Trombosi, Dipartimento di Clinica Medica, Immunologia e Malattie Infettive MIDIM, University of Bari School of Medicine, Italy
    Blood Coagul Fibrinolysis 14:95-8. 2003
    ..Further examinations also showed a double heterozygosis for G20210A prothrombin and factor V Leiden mutations...
  13. pmc Theoretical and experimental study of the D2194G mutation in the C2 domain of coagulation factor V
    M A Miteva
    French National Institute of Health and Medical Research INSERM U428, University Paris V, 75006 Paris, France
    Biophys J 86:488-98. 2004
    Coagulation factor V (FV) is a large plasma glycoprotein with functions in both the pro- and anticoagulant pathways...
  14. doi Risk assessment for recurrent venous thrombosis
    Paul Alexander Kyrle
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Lancet 376:2032-9. 2010
    ..Analysis of preliminary data suggests that risk assessment can also be refined through integration of prothrombotic coagulation changes and clinical risk factors...
  15. ncbi The limits of simulation of the clotting system
    R Wagenvoord
    Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, Netherlands
    J Thromb Haemost 4:1331-8. 2006
    ..To investigate in how far successful simulation of a thrombin generation (TG) curve gives information about the underlying biochemical reaction mechanism...
  16. ncbi Electrochemical genosensor based on colloidal gold nanoparticles for the detection of Factor V Leiden mutation using disposable pencil graphite electrodes
    Mehmet Ozsoz
    Department of Analytical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey
    Anal Chem 75:2181-7. 2003
    Electrochemical genosensors for the detection of the Factor V Leiden mutation from polymerase chain reaction (PCR) amplicons using the oxidation signal of colloidal gold (Au) is described...
  17. doi Adjuvant immunization induces high levels of pathogenic antiphospholipid antibodies in genetically prone mice: another facet of the ASIA syndrome
    A Katzav
    Department of Neurology and Sagol Center for Neurosciences, Sheba Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Lupus 21:210-6. 2012
    ..Patients with both antiphospholipid antibodies (aPL) and the genetic coagulopathy factor V Leiden (FVL) are frequently found...
  18. doi Combined Factor V and Factor VIII Deficiency
    Marta Spreafico
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, 20122 Milan, Italy
    Semin Thromb Hemost 35:390-9. 2009
    Combined deficiency of factor V (FV) and factor VIII (FVIII) (F5F8D, or FV+FVIII) is a autosomal recessive bleeding disorder caused by mutations in genes encoding two components of the endoplasmic reticulum (ER)-Golgi intermediate ..
  19. ncbi Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in 200 healthy Jordanians
    Suhair S Eid
    Molecular Laboratory, King Hussein Medical Centre, Jordan
    Clin Lab Sci 17:200-2. 2004
    ..In order to estimate the frequency of the factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in the Jordanian population, we screened 200 healthy ..
  20. ncbi Prevalence of factor V leiden, factor V cambridge, factor II G20210A and methylenetetrahydrofolate reductase C677T mutations in healthy and thrombophilic Serbian populations
    V Djordjevic
    Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia and Montenegro
    Acta Haematol 112:227-9. 2004
  21. ncbi Prevalence of factor V Leiden, prothrombin and methylene tetrahydrofolate reductase mutations in women with adverse pregnancy outcomes in Lebanon
    Laila F Zahed
    Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Lebanon
    Am J Obstet Gynecol 195:1114-8. 2006
    The purpose of this study was to determine the prevalence of factor V Leiden, prothrombin, and methylene tetrahydrofolate reductase gene mutations in women with adverse pregnancy outcome compared with women who had uneventful pregnancies.
  22. ncbi Prevalence of antiphospholipid antibodies, factor V G1691A (Leiden) and prothrombin G20210A mutations in early and late recurrent pregnancy loss
    Nabil Mtiraoui
    Research Unit of Haematological and Autoimmune Diseases, Faculty of Pharmacy, Monastir, Center University, Tunisia
    Eur J Obstet Gynecol Reprod Biol 119:164-70. 2005
    ..We assessed the prevalence of inherited (FV-Leiden and PRT G20210A), and acquired (anti-PL antibodies) risk factors among habitual aborters in Tunisia...
  23. ncbi Factor V Leiden and prothrombin gene G20210A mutations are uncommon in portal vein thrombosis in India
    Sanjay Sharma
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Gastroenterol 25:236-9. 2006
    ..The cause of thrombosis in these patients remains unclear. We studied the frequency of mutations in genes for coagulation factors V and II (prothrombin) in 61 Indian patients with PVT and 49 healthy control subjects...
  24. ncbi Prevalence of factor V Leiden in patients with myocardial infarction and normal coronary angiography
    J Mansourati
    Cardiology Department of Brest, North Hospital of Saint Etienne, France
    Thromb Haemost 83:822-5. 2000
    b>Factor V Leiden is associated with an increased risk of venous thrombosis and myocardial infarction in young women, but not in men in this latter case...
  25. ncbi Prevalence of factor V Leiden mutation and other hereditary thrombophilic factors in Egyptian children with portal vein thrombosis: results of a single-center case-control study
    Hanaa El-Karaksy
    Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
    Ann Hematol 83:712-5. 2004
    ..Our aim was to assess the prevalence of factor V Leiden mutation and other thrombophilic factors as risk factors in the development of PVT in the pediatric age ..
  26. ncbi Absence of factor V Leiden mutation and low prothrombin G 20210 A mutation prevalence in a healthy Moroccan population
    Florence Mathonnet
    Thromb Haemost 88:1073-4. 2002
  27. ncbi Factor V Leiden G1691A and prothrombin G20210A mutations are common in Tunisia
    C Frere
    J Thromb Haemost 1:2451-2. 2003
  28. doi Prevalence of angiotensin-converting enzyme, methylenetetrahydrofolate reductase, Factor V Leiden, prothrombin and apolipoprotein E gene polymorphisms in Morocco
    Thierry Paluku They-They
    Laboratoire de Génétique Médicale et Pathologie Moléculaire LGPM, Faculté de Médecine et de Pharmacie Casablanca, 19 rue Tarik Ibn Ziad, Casablanca, Morocco
    Ann Hum Biol 37:767-77. 2010
    ..These genetic factors are involved in several pathways affecting blood pressure regulation, blood coagulation, homocysteine and lipid metabolisms...
  29. doi Deep venous thrombosis and thrombophilic mutations in western Iran: association with factor V Leiden
    Zohreh Rahimi
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Iran
    Blood Coagul Fibrinolysis 21:385-8. 2010
    The aim of present study was to investigate the prevalence of factor V Leiden (FVL) c.1691G>A, prothrombin g.20210G>A and methylenetetrahydrofolate reductase (MTHFR) c...
  30. ncbi Allelic frequency of the factor V Leiden mutation and of the pro-thrombin gene 20210A mutation in healthy Tunisian population
    Lobna Bouaziz
    Thromb Haemost 91:824-5. 2004
  31. doi Prevalence of factor V Leiden and prothrombin G20210A mutation in a large French population selected for nonthrombotic history: geographical and age distribution
    Elisabeth Mazoyer
    Hématologie biologique, Hopital Lariboisiere, Paris, France
    Blood Coagul Fibrinolysis 20:503-10. 2009
    ..These polymorphisms confer a very mild hypercoagulable state as shown by the limited increased in basal D-dimers in mutated FV-G1691A populations and only a trend that does not reach statistical significance for FII-G20210A population...
  32. ncbi Prevalence of two thrombophilia predisposing mutations: factor V G1691A (R506Q; Leiden) and prothrombin G20210A, among healthy Lebanese
    Hala Tamim
    Thromb Haemost 88:691-2. 2002
  33. ncbi Prevalence and association of the factor V Leiden and prothrombin G20210A in healthy subjects and patients with venous thromboembolism
    D Coen
    Clinical Institute of Laboratory Diagnostics, Zagreb University Hospital Center, Zagreb, Croatia
    Croat Med J 42:488-92. 2001
    To determine the prevalences of factor V Leiden and the G20210A mutation in the prothrombin gene (PT20210A) and the frequency of their association in healthy subjects and in patients with venous thromboembolism (VTE).
  34. doi High incidence of factor V Leiden and prothrombin G20210A in healthy southern Italians
    Gianluca Sottilotta
    Centro Emofilia, Servizio Emostasi e Trombosi, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
    Clin Appl Thromb Hemost 15:356-9. 2009
    b>Factor V Leiden (FVL) and G20210 prothrombin (FII G20210A) mutations are risk factors for thromboembolism...
  35. ncbi Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis
    George Kovalevsky
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, USA
    Arch Intern Med 164:558-63. 2004
    ..Recently, thrombophilias have been implicated as a possible cause. Factor V Leiden (FVL) and prothrombin gene (G20210A) mutations are the most common types of hereditary thrombophilias, but ..
  36. doi Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis
    T Dudding
    Hunter Genetics, Hunter New England Health Service, NSW, Australia
    J Thromb Haemost 6:1869-75. 2008
    ..have suggested that there is a relationship between poor pregnancy outcomes and two polymorphisms, one in the factor V gene, the 1691G to A change (rs6025) located on chromosome 1q23 (factor V Leiden, FVL), and the other in the ..
  37. ncbi Malignancies, prothrombotic mutations, and the risk of venous thrombosis
    Jeanet W Blom
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    JAMA 293:715-22. 2005
    ..Venous thrombosis is a common complication in patients with cancer, leading to additional morbidity and compromising quality of life...
  38. ncbi Primary habitual abortions are associated with high frequency of factor V Leiden mutation
    M L Wramsby
    Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    Fertil Steril 74:987-91. 2000
    To analyze the prevalence of the mutation G1691A in factor V gene (Leiden mutation), of mutation C677T in the methylenetetrahydrofolate reductase (MTHFR) gene, and of polymorphism in G20210A in the prothrombin gene in women with recurrent ..
  39. ncbi Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis
    P Simioni
    Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University Hospital of Padua, Italy
    Blood 96:3329-33. 2000
    Carriers of a mutation in the prothrombin (clotting factor II) or factor V gene have a 2- to 4-fold greater risk for venous thromboembolism than subjects without the mutations...
  40. ncbi The thrombophilias: well-defined risk factors with uncertain therapeutic implications
    K A Bauer
    From Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts, USA
    Ann Intern Med 135:367-73. 2001
    Discovery of the factor V Leiden and prothrombin G20210A mutations has greatly increased the percentage of patients in whom venous thrombosis can be attributed to hereditary thrombophilia...
  41. ncbi Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden
    S Eichinger
    Department of Internal Medicine I, University Vienna, Austria
    Thromb Haemost 82:1232-6. 1999
    ..The risk of venous thrombosis is higher in pregnant women with factor V Leiden (FVL) than in those with wildtype factor V...
  42. doi Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review
    Jodi B Segal
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    JAMA 301:2472-85. 2009
    ..Testing for genetic risks for venous thromboembolism (VTE) is common, but the safety and utility of such testing need review...
  43. ncbi Factor V Leiden and prothrombin gene mutation may predispose to paradoxical embolism in subjects with patent foramen ovale
    Vesa Karttunen
    Department of Neurology, Oulu University Central Hospital, Box 25, FIN 90029 Oulu, Finland
    Blood Coagul Fibrinolysis 14:261-8. 2003
    ..We assessed the occurrence of several prothrombotic states (factor V Leiden, prothrombin G20210A, deficiencies in protein S, protein C and antithrombin, lupus anticoagulant, ..
  44. ncbi Prothrombotic mutations as risk factors for cryptogenic ischemic cerebrovascular events in young subjects with patent foramen ovale
    Nicoletta Botto
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Stroke 38:2070-3. 2007
    ..We evaluated the prevalence of the 2 most common genetic risk factors for thromboembolism, factor V Leiden (G1691A) and prothrombin G20210A, in young PFO patients who were referred for percutaneous transcatheter ..
  45. ncbi Distinct association of factor V-Leiden and prothrombin G20210A mutations with deep venous thrombosis in Tunisia and Lebanon
    Lobna Bouaziz-Borgi
    Faculty of Pharmacy, University of Monastir, Tunisia
    Am J Hematol 81:641-3. 2006
    b>Factor V G1691A (FV-Leiden) and prothrombin (PRT) G20210A single nucleotide polymorphisms (SNPs) were associated with venous thrombosis among Caucasians...
  46. ncbi Primer-engineered multiplex PCR-RFLP for detection of MTHFR C677T, prothrombin G20210A and factor V Leiden mutations
    Vedat Koksal
    Burc Molecular Diagnostic Laboratory, Istanbul, Turkey
    Exp Mol Pathol 83:1-3. 2007
    Single-nucleotide polymorphisms in the genes that code for coagulation factors V (factor V Leiden) and II (prothrombin, G20210A), as well as the methylenetetrahydrofolate reductase (MTHFR, C677T) gene, have been implicated in the majority ..
  47. doi Can Factor V Leiden and prothrombin G20210A testing in women with recurrent pregnancy loss result in improved pregnancy outcomes?: Results from a targeted evidence-based review
    Linda A Bradley
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Genet Med 14:39-50. 2012
    Women with recurrent pregnancy loss are offered Factor V Leiden (F5) and/or prothrombin G20210A (F2) testing to identify candidates for anticoagulation to improve outcomes...
  48. ncbi Livedoid vasculopathy in a patient with factor V mutation (Leiden)
    T Biedermann
    Department of Dermatology, Ludwig Maximilians University, Munich, Germany
    J Cutan Pathol 27:410-2. 2000
    ..For these forms, an unknown vaso-occlusive or thrombogenic process has been accused to play a role. Thus, a patient with livedoid vasculopathy was examined for different parameters which can be involved in coagulopathies...
  49. doi Broadening the factor V Leiden paradox: pulmonary embolism and deep-vein thrombosis as 2 sides of the spectrum
    Kirsten van Langevelde
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 120:933-46. 2012
    ..A well-known example is the factor V Leiden (FVL) paradox: the FVL mutation poses a clearly higher risk for deep-vein thrombosis (DVT) than for ..
  50. ncbi Increased titer of anti-beta2-glycoprotein I IgG antibody among factor V Leiden carriers during oral contraceptive use
    R Poka
    Department of Obstetrics and Gynecology, University of Debrecen, Medical and Health Science Cente, Nagyerdei krt 98, 4012 Debrecen, Hungary
    Contraception 69:27-30. 2004
    The risk of thromboembolism during oral contraceptive (OC) use is increased among factor V Leiden (FVL) carriers compared to women with wild-type genotype of the gene for coagulation factor V (FV)...
  51. doi The R306G and R506Q mutations in coagulation Factor V reveals additional cleavage sites for Activated Protein C in the R313-R321 region and at R505
    Richard J Dirven
    Einthoven Laboratory for Experimental Vascular Medicine, Dept of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Res 125:444-50. 2010
    The procoagulant function of activated factor V (FVa) is inhibited by activated Protein C (APC) through proteolytic cleavages at R306, R506 and R679...
  52. ncbi A male adolescent with left iliac thrombophlebitis and heterozygosity for factor V Leiden mutation
    Amy E Lovejoy
    Division of Hematology Oncology, Rady Children s Hospital, San Diego, CA 92123, USA
    J Pediatr Surg 44:1640-2. 2009
    ..J Intern Med. 2002;252:276-280). Secondly, resistance to activated protein C as a result of factor V Leiden is associated with thromboembolic disease at an early age (Price DT, Ridker PM. Ann Intern Med...
  53. ncbi Factor V Leiden and prothrombin G20210A mutations and the risk of atherothrombotic events in systemic lupus erythematosus
    Rudolf Pullmann
    Medical Clinic II, Jessenius Medical Faculty, Martin Faculty Hospital, Martin, Slovakia
    Clin Appl Thromb Hemost 10:233-8. 2004
    ..SLE) remains to be determined, the most common genetic prothrombotic factors, prothrombin G20210A and factor V Leiden mutations, were studied...
  54. ncbi Role of mesangial Factor V expression in crescent formation in rat experimental mesangioproliferative glomerulonephritis
    Takahiko Ono
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Pathol 204:229-38. 2004
    ..b>Factor V is a membrane-bound potent cofactor for the conversion of prothrombin to thrombin by Factor Xa...
  55. ncbi Endogenous factor V synthesis in megakaryocytes contributes negligibly to the platelet factor V pool
    M Christella L G D Thomassen
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Haematologica 88:1150-6. 2003
    Coagulation factor V (FV) is distributed between two pools: 80% circulates in plasma and 20% is stored in platelets. The aim of the study was to determine the origin of platelet FV.
  56. ncbi The Factor V Leiden mutation is associated with a higher blood haemoglobin concentration in women below 50 of the Malmö Thrombophilia Study (MATS)
    Nazim Isma
    Malmö Centre for Thrombosis and Haemostasis, Malmo, Sweden
    J Thromb Thrombolysis 28:255-8. 2009
    ....
  57. ncbi Factor II G20210A and factor V G1691A gene mutations and peripheral arterial occlusive disease
    W Renner
    Department of Medicine, Karl Franzens University, Graz, Austria
    Thromb Haemost 83:20-2. 2000
    G to A mutations at positions 20210 of the prothrombin gene (F2) and 1691 of the factor V gene (F5) are established risk factors for venous thrombosis...
  58. ncbi Factor V gene A4070G mutation and the risk of cerebral veno-sinus thrombosis occurring during puerperium
    Nagaraja Dindagur
    Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, Karnataka, India
    Thromb Res 119:497-500. 2007
    ..A recently identified polymorphism in factor V gene, A4070G (R2 allele), has been reported as a risk factor for venous thrombosis in some studies...
  59. ncbi The role of factor V Leiden and prothrombin G20210A mutations in sudden sensorineural hearing loss
    Kemal Gorur
    Department of Otorhinolaryngology, University of Mersin School of Medicine, Mersin, Turkey
    Otol Neurotol 26:599-601. 2005
    To investigate the incidence of factor V Leiden and prothrombin G20210A in sudden sensorineural hearing loss patients.
  60. ncbi Variable plasma levels of Factor V Leiden correlate with circulating platelet microparticles in carriers of Factor V Leiden
    Lisa F Lincz
    Hunter Haematology Research Group, Calvary Mater Newcastle Hospital, NSW, Australia
    Thromb Res 129:192-6. 2012
    Inheritance of Factor V Leiden (FVL) is associated with an increased but variable level of risk for thrombosis. We have previously shown that FVL heterozygotes have elevated levels of circulating pro-coagulant microparticles (MP)...
  61. doi Factor V deficiency: a concise review
    J N Huang
    Department of Pediatrics, UCSF Children s Hospital, San Francisco, California 94143 0106, USA
    Haemophilia 14:1164-9. 2008
    b>Factor V (FV; proaccelerin or labile factor) is the plasma cofactor for the prothrombinase complex that activates prothrombin to thrombin...
  62. ncbi Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcers
    Y Gaber
    Department of Dermatology, Medical University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Br J Dermatol 144:546-8. 2001
    ..Activated protein C (APC) resistance is the most frequently diagnosed heritable thrombophilic defect predisposing to thrombosis...
  63. doi Gene analysis and prenatal diagnosis for two families of congenital factor V deficiency
    L Cao
    The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China
    Haemophilia 17:65-9. 2011
    ..two families in which the probands had severe bleeding tendency and showed low plasma levels of coagulation factor V (FV) antigen and activity...
  64. ncbi Systemic-to-pulmonary artery shunt thrombosis in a neonate with factor V Leiden mutation
    Janet M Simsic
    Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Thorac Surg 74:2179-81. 2002
    ..Hematologic evaluation revealed heterozygous factor V Leiden mutation...
  65. ncbi Factor V Leiden, prothrombin G20210A, and protein C mutation frequency in Turkish venous thrombosis patients
    Julide Altinisik
    Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Clin Appl Thromb Hemost 14:415-20. 2008
    ..inherited polymorphisms are associated with risk of venous thrombosis, including mutation at codon 506 of the factor V gene, mutation at position 20210 of the prothrombin gene, and mutations in the protein C gene...
  66. ncbi The factor V Leiden mutation, high factor VIII, and high plasminogen activator inhibitor activity: etiologies for sporadic miscarriage
    Charles J Glueck
    Cholesterol Center, Department of Medicine, Jewish Hospital of Cincinnati, Cincinnati, OH 45229, USA
    Metabolism 54:1345-9. 2005
    We hypothesized that the thrombophilic G1691A factor V Leiden gene mutation was a common significant cause of sporadic first trimester miscarriage...
  67. ncbi The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis
    Tracy E Dudding
    Hunter Genetics, PO Box 84 Waratah, 2289, NSW, Australia
    Thromb Haemost 91:700-11. 2004
    The conclusions of studies to date which evaluate a possible association between factor V Leiden and adverse pregnancy outcome have been conflicting. This study was undertaken to further investigate this association...
  68. doi Deep venous thrombosis caused by congenital malformation of the inferior vena cava and heterozygous factor V leiden presenting as venous claudication
    Gary Fass
    Department of Emergency, Brugmann University Hospital, Brussels, Belgium
    Clin Appl Thromb Hemost 15:591-5. 2009
    ..thrombosis of the lower limbs caused by hypoplasia of the inferior vena cava in combination with heterozygous factor V Leiden is presented. Both anomalies were found when the patient complained of venous claudication in both thighs...
  69. ncbi Vascular behcet and mutations in thrombogenic genes: methylene tetrahydrofolate reductase, factor V, and prothrombin
    Efrat Dagan
    Department of Nursing, University of Haifa, Haifa, Israel
    Genet Test Mol Biomarkers 16:30-5. 2012
    ..The common inherited gene defects, factor V (FV) 1691A (Leiden), methylene tetrahydrofolate reductase (MTHFR) 677T, and prothrombin 20210A, are known risk ..
  70. pmc Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein
    Tim J Schuijt
    Center for Experimental and Molecular Medicine, University of Amsterdam, Meibergdreef 9, Room L01 145, 1105 AZ, Amsterdam, The Netherlands
    Circulation 128:254-66. 2013
    ..The current paradigm assumes that FV activation is initiated by limited proteolysis by traces of (meizo) thrombin...
  71. ncbi Factor V Leiden mutation in Sneddon syndrome
    R Besnier
    Service de Medecine Interne, Hopital de la Pitie, Paris, France
    Lupus 12:406-8. 2003
    ..Its pathophysiology is still controversial. The aim of this study was to evaluate the prevalence of factor V Leiden mutation in consecutive patients referred for SNS according to antiphospholipid antibodies (aPL) status...
  72. ncbi The role of platelets in venous thrombosis: a patient with Glanzmann's thrombasthenia and a factor V Leiden mutation suffering from deep venous thrombosis
    H ten Cate
    J Thromb Haemost 1:394-5. 2003
  73. ncbi Circulating microparticles are elevated in carriers of factor V Leiden
    Anoop K Enjeti
    Hunter Haematology Research Group, Calvary Mater Newcastle, Edith Street, Waratah, NSW 2298, Australia
    Thromb Res 126:250-3. 2010
    ..This study was carried out to evaluate if increased numbers or procoagulant potential of circulating MP contribute to the heterogeneity in occurrence of thrombosis in heterozygotes carrying Factor V Leiden (FVL) mutation.
  74. ncbi Interaction between factor V Leiden and serum LDL cholesterol increases the risk of atherosclerosis
    Henry Volzke
    Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Walther Rathenau Str 48, D 17487 Greifswald, Germany
    Atherosclerosis 180:341-7. 2005
    We investigated the association between the factor V Leiden gene variant and carotid atherosclerosis in a cross-sectional study and explored possible associations between this gene variant and coronary artery disease (CAD) in a case-..
  75. doi Factor V Leiden mutation does not affect coagulopathy or outcome in lethal H1N1 influenza
    M Schouten
    Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Eur Respir J 36:1346-54. 2010
    ..Knowledge on coagulation activation in influenza infection is limited. The factor V Leiden (FVL) mutation is possibly subject to positive selection pressure...
  76. doi Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy
    Hongjie Wang
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Blood 117:5231-42. 2011
    ..The high prevalence of the prothrombotic factor V Leiden (FVL) mutation in whites has been attributed to a positive selection pressure (eg, resulting from reduced ..
  77. ncbi Combined factor V Leiden and prothrombin genotyping in patients presenting with thromboembolic episodes
    J A Friedline
    Kennewick, Wash, USA
    Arch Pathol Lab Med 125:105-11. 2001
    Several genetic defects are associated with increased risk of venous thrombosis. The factor V Leiden (FVL) and prothrombin G20210A mutations are the most frequent causes of inherited thrombophilia.
  78. ncbi Central retinal artery occlusion in a patient homozygous for factor V Leiden
    J Larsson
    Department of Ophthalmology, Lund University Hospital, Lund, Sweden
    Am J Ophthalmol 129:816-7. 2000
    To report an association between central retinal artery occlusion and homozygosity for factor V Leiden.
  79. ncbi No excess of factor V:Q506 genotype but high prevalence of anticardiolipin antibodies without antiendothelial cell antibodies in retinal vein occlusion in young patients
    J A Scott
    Department of Ophthalmology, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, UK
    Ophthalmologica 215:217-21. 2001
    b>Factor V:Q506 (factor V Leiden) is associated with venous thrombosis and has been reported to be a risk factor for retinal vein occlusion (RVO)...
  80. ncbi Factor V Leiden and the etiology of inflammatory bowel disease
    C Arnold Spek
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thromb Haemost 98:670-3. 2007
    ..We therefore conclude that the FV Leiden allele has no effect in murine colitis and we thus question the importance of activated blood coagulation in the etiology or pathogenesis of IBD...
  81. doi Factor V Leiden is associated with more distal location of deep vein thrombosis of the leg
    M V Huisman
    J Thromb Haemost 6:544-5. 2008
  82. ncbi A mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunisia
    Avichai Segal
    Thrombosis and Hemostasis Research Institute, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood Coagul Fibrinolysis 15:99-102. 2004
    Combined deficiency of factor V and factor VIII is a rare autosomal recessive bleeding disorder that is caused by mutations in the LMAN1 or MCFD2 genes...
  83. ncbi Location and extent of deep vein thrombosis in patients with and without FV:R 506Q mutation
    O Björgell
    Department of Diagnostic Radiology, University of Lund, Malmo University Hospital, Malmo, Sweden
    Thromb Haemost 83:648-51. 2000
    ..0001). Our findings provide the basis of a detailed phlebographic description and for the first time, to our best knowledge, shows a specific phlebographic pattern that may be linked to an inherited hypercoagulable state...
  84. doi The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease
    P M Mannucci
    Centro Emofilia e Trombosi A Bianchi Bonomi, Scientific Direction, IRCCS Fondazione Cà Granda Ospedale Maggiore, Universita degli Studi di Milano, Milan, Italy
    J Thromb Haemost 8:2116-21. 2010
    ....
  85. doi Development of factor V and thrombin inhibitors in children following bovine thrombin exposure during cardiac surgery: a report of three cases
    Lisa Bomgaars
    Department of Pediatrics, Hematology Oncology Section, Baylor College of Medicine, Houston, TX 77030, USA
    Congenit Heart Dis 5:303-8. 2010
    b>Factor V and thrombin inhibitors may develop following exposure to bovine thrombin preparations...
  86. ncbi Renin-angiotensin system and haemostasis gene polymorphisms and outcome after coronary artery bypass graft surgery
    Henry Volzke
    Department of Epidemiology and Social Medicine, Ernst Moritz Arndt University, Walther Rathenau Str 48, D 17487 Greifswald, Germany
    Int J Cardiol 98:133-9. 2005
    ..system (angiotensinogen 235 M/T, angiotensin II type 1 receptor 1166 A/C) or the clotting system (glycoprotein IIIa PlA1/PlA2 and factor V Leiden 1691 G/A) are associated with the outcome after coronary artery bypass grafting.
  87. ncbi Analysis of the factor V Leiden mutation using the READIT Assay
    R B Rhodes
    University of Minnesota, Minneapolis, MN, USA
    Mol Diagn 6:55-61. 2001
    ..We show the application of a novel SNP scoring tool for analysis of the factor V Leiden mutation. METHODS AND RESULTS: We have developed a novel method for analyzing SNPs...
  88. ncbi Prevalence of resistance against activated protein C resulting from factor V Leiden is significantly increased in myocardial infarction: investigation of 507 patients with myocardial infarction
    Katharina Middendorf
    Medical Clinic I, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany
    Am Heart J 147:897-904. 2004
    A point mutation in the gene encoding coagulation factor V is a cause of resistance against activated protein C. The presence of factor V Leiden is linked to 50% of congenital defects causing venous thrombosis...
  89. ncbi Association of factor V gene polymorphisms (Leiden; Cambridge; Hong Kong and HR2 haplotype) with recurrent idiopathic pregnancy loss in Tunisia. A case-control study
    Walid Zammiti
    Research Unit of Haematological and Autoimmune Diseases, Faculty of Pharmacy, Monastir, Center University, Tunisia
    Thromb Haemost 95:612-7. 2006
    ..We performed a case-control study on the association between thrombosis-related polymorphisms in the factor V (FV) gene (Leiden, Cambridge, Hong Kong; HR2 haplotype) and idiopathic recurrent pregnancy loss (RPL) in Tunisian ..
  90. ncbi Factor V Leiden mutation in venous thrombosis in southeast Turkey
    Sevgi Kalkanli
    Department of Medical Genetic Biology, University of Dicle, Diyarbakir, Turkey
    Angiology 57:193-6. 2006
    ..b>Factor V Leiden mutation (G1691A) (FVL) is the most common risk factor in venous thrombosis...
  91. ncbi Arterial thrombosis associated with heterozygous factor V Leiden disorder, hyperhomocysteinemia, and peripheral arterial disease: importance of synergistic factors
    Cameron Page
    Department of Surgery, VA Connecticut Healthcare System, Yale University School of Medicine, New Haven, CT 06519, USA
    J Vasc Surg 42:1014-8. 2005
    A 47-year-old man with heterozygous factor V Leiden disorder and intermittent hyperhomocysteinemia developed spontaneous acute popliteal artery thrombosis. Homocysteine levels were above normal limits at presentation...
  92. ncbi Population genetics of factor V Leiden in Europe
    G Lucotte
    International Institute of Anthropology, 1 place d Iéna, Paris 16ème, France
    Blood Cells Mol Dis 27:362-7. 2001
    ..originating from 26 geographically defined populations in Europe and neighboring countries for the presence of factor V Leiden, an important genetic risk factor in venous thromboembolism...
  93. ncbi Prevalence of factor V Leiden and G6PD 1311 silent mutations in Dalmatian population
    Vedrana Cikes
    Laboratory for Molecular Biology, University of Split, School of Medicine, Split, Croatia
    Arch Med Res 35:546-8. 2004
    b>Factor V Leiden has been described as a common genetic risk factor for venous thromboembolism. The geographic distribution of this abnormality varies greatly, being high in Europe and almost absent in Asia and Africa...
  94. ncbi Prevalence of factor V Leiden and prothrombin G20210A gene mutation
    Ahmet Irdem
    Department of Pediatrics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
    Saudi Med J 26:580-3. 2005
    To determine the prevalence of factor V Leiden (FVL) and prothrombin gene (PG) 20210A mutations in patients who attended the outpatient clinic and do not have a family history of thrombosis.
  95. ncbi An Arab selective gradient in the distribution of factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T
    G Ameen
    J Thromb Haemost 3:2126-7. 2005
  96. ncbi Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR G677A among 594 thrombotic Jordanian patients
    Suhair S Eid
    King Hussein Medical Center, Princess Iman Research Center for Laboratory Sciences, Amman, Jordan
    Blood Coagul Fibrinolysis 16:417-21. 2005
    ..In order to estimate the frequency of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in Jordanian thrombotic patients, we studied 594 patients ..
  97. ncbi Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial protein C receptor (EPCR) gene on the risk of venous thromboembolism in carriers of factor V Leiden
    Pilar Medina
    Research Center, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 94:389-94. 2005
    ..The objective of this study was to assess whether these polymorphisms modify the risk of VTE in carriers of factor V (FV) Leiden...
  98. ncbi The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or both
    I Martinelli
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, University of Milan, Italy
    Br J Haematol 111:1223-9. 2000
    b>Factor V Leiden and the G20210A mutation in the prothrombin gene are the most frequent abnormalities associated with venous thromboembolism. It is unknown whether the risks due to the presence of either mutation are of the same magnitude...
  99. doi Factor V Leiden thrombophilia
    Jody Lynn Kujovich
    Northwest Cancer Specialists, Portland, OR 97227, USA
    Genet Med 13:1-16. 2011
    b>Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to activated Protein C and an increased risk for venous thromboembolism...
  100. doi Race differences in the prevalence of the factor V Leiden mutation in Kuwaiti nationals
    Ali A Dashti
    Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, P O Box 31470, 90805, Sulaibekhat, Kuwait
    Mol Biol Rep 38:3623-8. 2011
    b>Factor V Leiden mutation (FVL; G1691A) is an established risk factor for venous thromboembolic disorders. FVL was reported with high prevalence in Caucasians (1-15%) but was absent in non-Caucasians like Africans and Asians...
  101. pmc Decision analysis model of prolonged oral anticoagulant treatment in factor V Leiden carriers with first episode of deep vein thrombosis
    F P Sarasin
    Medical Clinics, Hospital Cantonal, University of Geneva Medical School, Switzerland
    BMJ 316:95-9. 1998
    ..treatment extended beyond 3 months after a first episode of deep vein thrombosis in patients who carry factor V Leiden mutation...

Research Grants80

  1. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
    ..A membrane binding site was localized to the factor V C2 domain and the structures of two crystal forms of this domain have been elucidated...
  2. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 2009
    ..A membrane binding site was localized to the factor V C2 domain and the structures of two crystal forms of this domain have been elucidated...
  3. NICHD Maternal Fetal Medicine Units Network
    Brian Mercer; Fiscal Year: 2009
    ..fetal pulse oximetry in labor, treatment of mild gestational diabetes, vaginal birth after cesarean, Factor V Leiden mutation carriage)...
  4. NICHD Maternal Fetal Medicine Units Network
    Brian M Mercer; Fiscal Year: 2011
    ..fetal pulse oximetry in labor, treatment of mild gestational diabetes, vaginal birth after cesarean, Factor V Leiden mutation carriage)...
  5. NICHD Maternal Fetal Medicine Units Network
    Brian Mercer; Fiscal Year: 2006
    ..fetal pulse oximetry in labor, treatment of mild gestational diabetes, vaginal birth after cesarean, Factor V Leiden mutation carriage)...
  6. NICHD Maternal Fetal Medicine Units Network
    Brian Mercer; Fiscal Year: 2007
    ..fetal pulse oximetry in labor, treatment of mild gestational diabetes, vaginal birth after cesarean, Factor V Leiden mutation carriage)...
  7. NICHD Maternal Fetal Medicine Units Network
    Brian M Mercer; Fiscal Year: 2010
    ..fetal pulse oximetry in labor, treatment of mild gestational diabetes, vaginal birth after cesarean, Factor V Leiden mutation carriage)...
  8. METAL-DEPENDENT COMPLEXES IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 1980
    ..lanthanide ions will be carried out on factor Xa, factor IX and factor IXa, abnormal prothrombin, factor VIII and factor V. Where appropriate, affinity chromatographic methods of purification will be explored for these proteins using ..
  9. Role of PAI-1 in Venous THrombosis
    Thomas Wakefield; Fiscal Year: 2009
    ..PAI-1 levels are elevated by hyperlipidemia, and PAI-1 elevation appears to synergize with Factor V Leiden genetic abnormalities, a thrombophilic mutation of Factor V (Leiden) which renders it resistent to ..
  10. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul E Bock; Fiscal Year: 2010
    b>Factor V plays a pivotal role in hemostasis, and in the pathology of venous thrombosis...
  11. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul Bock; Fiscal Year: 2009
    b>Factor V plays a pivotal role in hemostasis, and in the pathology of venous thrombosis...
  12. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul Bock; Fiscal Year: 2007
    b>Factor V plays a pivotal role in hemostasis, and in the pathology of venous thrombosis...
  13. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 2003
    ..that two tryptophans located in a mobile solvent exposed loop play a critical role in high affinity binding of factor V to phospholipid membranes containing low concentrations of phosphatidylserine...
  14. Membrane Receptors Regulating Megakaryocyte Endocytosis of Factor V from Plasma
    BETH BOUCHARD; Fiscal Year: 2009
    ..Recently, our laboratory demonstrated that the entire pool of the platelet-derived procofactor, factor V, originates from plasma through endocytosis of factor V by platelet precursors, megakaryocytes, via a two ..
  15. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 2002
    ..that two tryptophans located in a mobile solvent exposed loop play a critical role in high affinity binding of factor V to phospholipid membranes containing low concentrations of phosphatidylserine...
  16. Membrane Receptors Regulating Megakaryocyte Endocytosis of Factor V from Plasma
    BETH BOUCHARD; Fiscal Year: 2010
    ..Recently, our laboratory demonstrated that the entire pool of the platelet-derived procofactor, factor V, originates from plasma through endocytosis of factor V by platelet precursors, megakaryocytes, via a two ..
  17. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 2000
    ..that two tryptophans located in a mobile solvent exposed loop play a critical role in high affinity binding of factor V to phospholipid membranes containing low concentrations of phosphatidylserine...
  18. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 2001
    ..that two tryptophans located in a mobile solvent exposed loop play a critical role in high affinity binding of factor V to phospholipid membranes containing low concentrations of phosphatidylserine...
  19. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 2004
    ..that two tryptophans located in a mobile solvent exposed loop play a critical role in high affinity binding of factor V to phospholipid membranes containing low concentrations of phosphatidylserine...
  20. Identifying novel genetic risk factors for venous thromboembolism (VTE)
    Jun Li; Fiscal Year: 2012
    ..However, known common variants, confirmed in recent genome-wide association studies (GWAS), such as Factor V Leiden and the ABO blood group, account for only half of this risk...
  21. MOLECULAR BASIS OF BLOOD COAGULATION REGULATION
    Steven T Olson; Fiscal Year: 2010
    ..in the case of anti-thrombin and increased thrombosis when mice are given a thrombotic challenge or are bred on a factor V Leiden background in the case of ZPI...
  22. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 2007
    ..A membrane binding site was localized to the factor V C2 domain and the structures of two crystal forms of this domain have been elucidated...
  23. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 2006
    ..A membrane binding site was localized to the factor V C2 domain and the structures of two crystal forms of this domain have been elucidated...
  24. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 1991
    DESCRIPTION: (Adapted from the investigator's abstract). Factor V is a protein cofactor that is essential for the prothrombinase complex. This complex consists of factor Va, factor Xa, calcium, and a phospholipid surface...
  25. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 1992
    DESCRIPTION: (Adapted from the investigator's abstract). Factor V is a protein cofactor that is essential for the prothrombinase complex. This complex consists of factor Va, factor Xa, calcium, and a phospholipid surface...
  26. RELATIONSHIPS BETWEEN COAGULATION AND THROMBOSIS
    SAMUEL RAPAPORT; Fiscal Year: 1991
    ..Other clinical projects will include studies of (1) the importance of platelet factor V for hemostasis in patients with factor V anticoagulants, (2) the relation between antiprothrombin antibodies and ..
  27. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    WILLIAM KANE; Fiscal Year: 1993
    DESCRIPTION: (Adapted from the investigator's abstract). Factor V is a protein cofactor that is essential for the prothrombinase complex. This complex consists of factor Va, factor Xa, calcium, and a phospholipid surface...
  28. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2004
    ..if patients with PE complicated by an adverse outcome are more likely to have antiphospholipid antibodies, or factor V Leiden G1691A, prothrombin G20210A, methylenetetrahydrofolate reductase C677T mutations, or low red blood cell ..
  29. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..if patients with PE complicated by an adverse outcome are more likely to have antiphospholipid antibodies, or factor V Leiden G1691A, prothrombin G20210A, methylenetetrahydrofolate reductase C677T mutations, or low red blood cell ..
  30. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2003
    ..if patients with PE complicated by an adverse outcome are more likely to have antiphospholipid antibodies, or factor V Leiden G1691A, prothrombin G20210A, methylenetetrahydrofolate reductase C677T mutations, or low red blood cell ..
  31. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..from which DNA will be extracted and assayed for genetic mutations and polymorphisms, including those for factor V Leiden (1691G yields A), prothrombin gene (20210G yields A), the 677C yields T and 1298A yields C polymorphisms ..
  32. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2002
    ..from which DNA will be extracted and assayed for genetic mutations and polymorphisms, including those for factor V Leiden (1691G yields A), prothrombin gene (20210G yields A), the 677C yields T and 1298A yields C polymorphisms ..
  33. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2003
    ..from which DNA will be extracted and assayed for genetic mutations and polymorphisms, including those for factor V Leiden (1691G yields A), prothrombin gene (20210G yields A), the 677C yields T and 1298A yields C polymorphisms ..
  34. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2004
    ..from which DNA will be extracted and assayed for genetic mutations and polymorphisms, including those for factor V Leiden (1691G yields A), prothrombin gene (20210G yields A), the 677C yields T and 1298A yields C polymorphisms ..
  35. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2005
    ..from which DNA will be extracted and assayed for genetic mutations and polymorphisms, including those for factor V Leiden (1691G yields A), prothrombin gene (20210G yields A), the 677C yields T and 1298A yields C polymorphisms ..
  36. ORAL CONTRACEPTIVES AND THROMBOEMBOLIC DISEASE
    Stephen Sidney; Fiscal Year: 1999
    ..users of low-dose (<50 micrograms estrogen) oral contraceptive (OC) preparations; and b) the prevalence of the factor V Leiden mutation in cases and controls and the relative and attributable risk of venous thromboembolic disease ..
  37. ORAL CONTRACEPTIVES AND THROMBOEMBOLIC DISEASE
    Stephen Sidney; Fiscal Year: 2000
    ..users of low-dose (<50 micrograms estrogen) oral contraceptive (OC) preparations; and b) the prevalence of the factor V Leiden mutation in cases and controls and the relative and attributable risk of venous thromboembolic disease ..
  38. Functional Domains of Coagulation Factor V
    Michael Kalafatis; Fiscal Year: 2004
    ..The procofactor, factor V, does not participate in prothrombinase...
  39. Functional Domains of Coagulation Factor V
    Michael Kalafatis; Fiscal Year: 2006
    ..The procofactor, factor V, does not participate in prothrombinase...
  40. Functional Domains of Coagulation Factor V
    Michael Kalafatis; Fiscal Year: 2007
    ..The procofactor, factor V, does not participate in prothrombinase...
  41. Functional Domains of Coagulation Factor V
    Michael Kalafatis; Fiscal Year: 2005
    ..The procofactor, factor V, does not participate in prothrombinase...
  42. Functional Domains of Coagulation Factor V
    Michael Kalafatis; Fiscal Year: 2006
    ..The procofactor, factor V, does not participate in prothrombinase...
  43. Thrombin Formation Inhibitors
    James Phillips; Fiscal Year: 2004
    ..Generation of DVT is strongly correlated with the function of factor V, a protein cofactor for prothrombinase...
  44. PREVENT: PREVENTION OF RECURRENT VENOUS THROMBOEMBOLISM
    Nigel Key; Fiscal Year: 2000
    ..and for patients at increased risk due to the presence of inherited defects of anticoagulation such as the factor V Leiden mutation...
  45. PDl: Function in thrombus formation and antithrombotic action of inhibitors in m
    Bruce Furie; Fiscal Year: 2012
    ..fetal/neonatal demise by quercetin will be tested in two mouse models: perinatal thrombosis with homozygous Factor V Leiden and heterozygous TFPI deficiency, and consumptive coagulopathy with homozygous protein C deficiency...
  46. Identifying Thrombosis Modifier Genes in the Mouse
    David Ginsburg; Fiscal Year: 2011
    ..Genes in the Mouse The genetic factors responsible for the highly variable clinical course of patients with factor V Leiden and other forms of thrombophilia are unknown...
  47. Identifying Thrombosis Modifier Genes in the Mouse
    David Ginsburg; Fiscal Year: 2009
    ..Genes in the Mouse The genetic factors responsible for the highly variable clinical course of patients with factor V Leiden and other forms of thrombophilia are unknown...
  48. MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISM
    Bruce Psaty; Fiscal Year: 2001
    DESCRIPTION: (Adapted from Investigator's Abstract) Epidemiologic studies have identified Factor V Leiden as the most common cause of heritable thrombophilia a prothrombotic mutation associated with a 5 to 7-fold increase in the risk of ..
  49. MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISM
    Bruce Psaty; Fiscal Year: 2000
    DESCRIPTION: (Adapted from Investigator's Abstract) Epidemiologic studies have identified Factor V Leiden as the most common cause of heritable thrombophilia a prothrombotic mutation associated with a 5 to 7-fold increase in the risk of ..
  50. MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISM
    Bruce Psaty; Fiscal Year: 1999
    DESCRIPTION: (Adapted from Investigator's Abstract) Epidemiologic studies have identified Factor V Leiden as the most common cause of heritable thrombophilia a prothrombotic mutation associated with a 5 to 7-fold increase in the risk of ..
  51. VITAMIN K-DEPENDENT PROTEINS IN LIVER & ISOLATED CELLS
    Reidar Wallin; Fiscal Year: 1992
    ..Pulmonary macrophages produce tissue factor and factor V but appear to be devoid of carboxylase activity...
  52. DEFINITION OF FUNCTIONAL SITES ON COAGULATION FACTOR X
    WILLIAM CHURCH; Fiscal Year: 1990
    ..a supramolecular complex, termed prothrombinase, consisting of an enzyme (Factor X alpha), a protein cofactor (Factor V alpha), calcium ion, and a phospholipid surface...
  53. FIBRONECTIN IN PULMONARY TUBERCULOSIS
    Jesse Roman; Fiscal Year: 1993
    ....
  54. VITAMIN K-DEPENDENT PROTEINS IN LIVER & ISOLATED CELLS
    Reidar Wallin; Fiscal Year: 1990
    ..Pulmonary macrophages produce tissue factor and factor V but appear to be devoid of carboxylase activity...
  55. ACTIVATION OF PROTHROMBIN IN WHOLE HUMAN BLOOD
    Kenneth Mann; Fiscal Year: 1999
    ..during a coagulation event in terms of thrombin generation, platelet activation, fibrinopeptide production, factor V (fV) and prothrombin activation...
  56. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 1990
    ..permit microchemical analysis of protein structure, the recent discovery of the total amino acid sequence of factor V by this laboratory and experience gained in the expression of the factor VIII molecule, we are in a position to ..
  57. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2000
    b>Factor V is a central participant in the blood clotting process...
  58. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2002
    b>Factor V is a central participant in the blood clotting process...
  59. BLOOD CLOTTING KINETICS STUDIED BY RADIOIMMUNOASSAY
    Marc Shuman; Fiscal Year: 1980
    ..Our specific objectives are: 1) To determine the role of factor V in prothrombin as it occurs in blood clotting and the effect of activation of factor V by thrombin on subsequent ..
  60. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2003
    b>Factor V is a central participant in the blood clotting process...
  61. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 1999
    b>Factor V is a central participant in the blood clotting process...
  62. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2001
    b>Factor V is a central participant in the blood clotting process...
  63. Processed Defining Megakaryocyte Endocytosis of Factor V
    PAULA TRACY; Fiscal Year: 2003
    ..the rate of thrombin generation, the physiologic effect being demonstrated by the severe hemorrhage observed in factor V deficiency...
  64. Processed Defining Megakaryocyte Endocytosis of Factor V
    PAULA TRACY; Fiscal Year: 2004
    ..the rate of thrombin generation, the physiologic effect being demonstrated by the severe hemorrhage observed in factor V deficiency...
  65. Processed Defining Megakaryocyte Endocytosis of Factor V
    PAULA TRACY; Fiscal Year: 2002
    ..the rate of thrombin generation, the physiologic effect being demonstrated by the severe hemorrhage observed in factor V deficiency...
  66. Processed Defining Megakaryocyte Endocytosis of Factor V
    PAULA TRACY; Fiscal Year: 2005
    ..the rate of thrombin generation, the physiologic effect being demonstrated by the severe hemorrhage observed in factor V deficiency...
  67. Discovery of antivirals against vaccinia and smallpox
    Robert Ricciardi; Fiscal Year: 2002
    ..The approach may help deliver the 'just-in-time' need for reagents to combat a smallpox bioterrorism threat. ..
  68. Discovery of antivirals against vaccinia and smallpox
    Robert Ricciardi; Fiscal Year: 2003
    ..The approach may help deliver the 'just-in-time' need for reagents to combat a smallpox bioterrorism threat. ..
  69. COMMON VARIANTS IN CANDIDATE GENES AND PREMATURE MI RISK
    Stephen Schwartz; Fiscal Year: 2000
    ..Those data show that common polymorphisms in genes coding for two clotting factors, coagulation Factor V and coagulation Factor II, are risk factors for MI only among cigarette smokers in this sample...
  70. COMMON VARIANTS IN CANDIDATE GENES AND PREMATURE MI RISK
    Stephen Schwartz; Fiscal Year: 2001
    ..Those data show that common polymorphisms in genes coding for two clotting factors, coagulation Factor V and coagulation Factor II, are risk factors for MI only among cigarette smokers in this sample...
  71. COMMON VARIANTS IN CANDIDATE GENES AND PREMATURE MI RISK
    Stephen Schwartz; Fiscal Year: 1999
    ..Those data show that common polymorphisms in genes coding for two clotting factors, coagulation Factor V and coagulation Factor II, are risk factors for MI only among cigarette smokers in this sample...