protoporphyrins

Summary

Summary: Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.

Top Publications

  1. ncbi Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium
    Bela Juhasz
    Department of Pharmacology, Health Science Center, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary
    J Cell Mol Med 15:1973-82. 2011
  2. ncbi Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    Ming Li
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Diabetes 57:1526-35. 2008
  3. ncbi Apoptosis induced by sonodynamic treatment by protoporphyrin IX on MDA-MB-231 cells
    Yixiang Li
    Key Laboratory of Ministry of Education for Medicinal Plant Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, China
    Ultrasonics 52:490-6. 2012
  4. pmc 5-aminolevulinic acid-incorporated poly(vinyl alcohol) nanofiber-coated metal stent for application in photodynamic therapy
    Jin Ju Yoo
    National Research and Development Center for Hepatobiliary Diseases, Pusan National University Yangsan Hospital, Gyeongnam 626 770, Korea
    Int J Nanomedicine 7:1997-2005. 2012
  5. ncbi A spectroscopic study of the photobleaching of protoporphyrin IX in solution
    M B Ericson
    Department of Experimental Physics, School of Physics and Engineering Physics, Chalmers University of Technology, Goteborg University, SE 412 96 Goteborg, Sweden
    Lasers Med Sci 18:56-62. 2003
  6. pmc Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain
    Rolf B Saager
    University of California Irvine, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA
    J Biomed Opt 16:126013. 2011
  7. ncbi Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells
    Won Yong Seo
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Republic of Korea
    Biochem Biophys Res Commun 398:140-5. 2010
  8. ncbi Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    Dong Hyun Kim
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 325:833-40. 2008
  9. ncbi 5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institutuion
    M Hefti
    Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
    Swiss Med Wkly 138:180-5. 2008
  10. ncbi Damage effects of protoporphyrin IX - sonodynamic therapy on the cytoskeletal F-actin of Ehrlich ascites carcinoma cells
    Xia Zhao
    College of Life Sciences, Shaanxi Normal University, Xi an, Shaanxi 710062, China
    Ultrason Sonochem 16:50-6. 2009

Detail Information

Publications261 found, 100 shown here

  1. ncbi Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium
    Bela Juhasz
    Department of Pharmacology, Health Science Center, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary
    J Cell Mol Med 15:1973-82. 2011
    ..Immunohistochemical staining of HO-1 was intensified in HO-1 Tg compared to the NTg myocardium. Thus, the HO-1 Tg mouse model suggests a valuable therapeutic approach in the treatment of ischemic myocardium...
  2. ncbi Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    Ming Li
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Diabetes 57:1526-35. 2008
    ....
  3. ncbi Apoptosis induced by sonodynamic treatment by protoporphyrin IX on MDA-MB-231 cells
    Yixiang Li
    Key Laboratory of Ministry of Education for Medicinal Plant Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, China
    Ultrasonics 52:490-6. 2012
    ..These findings primarily indicate a Caspase-depended apoptosis could be induced by PpIX-SDT in MDA-MB-231 cells, and the intracellular ROS was involved during the apoptotic process...
  4. pmc 5-aminolevulinic acid-incorporated poly(vinyl alcohol) nanofiber-coated metal stent for application in photodynamic therapy
    Jin Ju Yoo
    National Research and Development Center for Hepatobiliary Diseases, Pusan National University Yangsan Hospital, Gyeongnam 626 770, Korea
    Int J Nanomedicine 7:1997-2005. 2012
    ..For this purpose, 5-aminolevulinic acid (ALA) was incorporated into poly(vinyl alcohol) (PVA) nanofiber, and coated onto metal stents. Their efficacy was assessed in PDT towards HuCC-T1 CC cells...
  5. ncbi A spectroscopic study of the photobleaching of protoporphyrin IX in solution
    M B Ericson
    Department of Experimental Physics, School of Physics and Engineering Physics, Chalmers University of Technology, Goteborg University, SE 412 96 Goteborg, Sweden
    Lasers Med Sci 18:56-62. 2003
    ..When comparing our results to the studies carried out by N(2) bubbling, the N(2) bubbling seems to be insufficient to remove the oxygen completely from the solution...
  6. pmc Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain
    Rolf B Saager
    University of California Irvine, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA
    J Biomed Opt 16:126013. 2011
    ..This method was subsequently applied to the determination of PpIX concentration from in vivo normal skin where the model-based correction determined a concentration of 1.6 μg/ml, which is in agreement with literature...
  7. ncbi Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells
    Won Yong Seo
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Republic of Korea
    Biochem Biophys Res Commun 398:140-5. 2010
    ..These results suggest that celastrol may exert anti-inflammatory responses by suppressing IFN-gamma-induced expression of ICAM-1 and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes...
  8. ncbi Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    Dong Hyun Kim
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 325:833-40. 2008
    ..These findings highlight the pivotal role and symbiotic relationship of HO-1 and adiponectin in the modulation of the metabolic syndrome phenotype...
  9. ncbi 5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institutuion
    M Hefti
    Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
    Swiss Med Wkly 138:180-5. 2008
    ..We report on the feasibility of the method in daily clinical practice, the benefits for patients and surgeons, the technical limitations and the methods we have devised of overcoming these limitations...
  10. ncbi Damage effects of protoporphyrin IX - sonodynamic therapy on the cytoskeletal F-actin of Ehrlich ascites carcinoma cells
    Xia Zhao
    College of Life Sciences, Shaanxi Normal University, Xi an, Shaanxi 710062, China
    Ultrason Sonochem 16:50-6. 2009
    ..Our results showed that cytoskeletal F-actin might represent an important target for the SDT treatment and the observed effect on F-actin and the subsequent bleb formation mainly due to apoptosis formation due to the treatment...
  11. pmc Heme oxygenase-1 promotes the persistence of Leishmania chagasi infection
    Nívea F Luz
    Centro de Pesquisas Gonçalo Moniz Fundação Oswaldo Cruz, Salvador 40295 001, Brazil
    J Immunol 188:4460-7. 2012
    ..Our data argue that HO-1 has a critical role in the L. chagasi infection and is strongly associated with the inflammatory imbalance during VL. Manipulation of HO-1 pathways during VL could serve as an adjunctive therapeutic approach...
  12. pmc A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase
    Carrie Hiser
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, United States
    Biochemistry 52:1385-96. 2013
    ..The high affinity and specificity of a number of compounds for this region, and its conservation and impact on CcO activity, support its physiological significance...
  13. ncbi Detection and photodynamic therapy of inflamed atherosclerotic plaques in the carotid artery of rabbits
    Chenghai Peng
    Department of Cardiology, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, PR China
    J Photochem Photobiol B 102:26-31. 2011
    ..ALA mediated PDT could reduce macrophage content and inhibit plaque progression, indicating a promising approach to treat inflamed atherosclerotic plaques...
  14. ncbi Precise detection of lymph node metastases in mouse rectal cancer by using 5-aminolevulinic acid
    Yasutoshi Murayama
    Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Cancer 125:2256-63. 2009
    ..c) 2009 uicc...
  15. ncbi Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma
    Yanhong Lv
    Department of Anatomy, Harbin Medical University, Harbin, P R China
    Cell Physiol Biochem 30:321-33. 2012
    ..The process initially damaged mitochondria, activated pro-apoptotic factors Bax and cytochrome c and suppressed the anti-apoptotic factor Bcl-2, activated caspase-3 to executed apoptosis through mitochondrial signaling pathway...
  16. ncbi Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo
    Konstantin Tsoyi
    Department of Pharmacology, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea
    Mol Pharmacol 76:173-82. 2009
    ..Taken together, we concluded that HO-1-derived CO reduces HMGB1 release in LPS-activated cells and LPS- or CLP-induced animal model of sepsis...
  17. ncbi Kinetics and subcellular localization of 5-ALA-induced PpIX in DHL cells via two-photon excitation fluorescence microscopy
    Rong Chen
    Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou, Fujian 350007, PR China
    Int J Oncol 32:861-7. 2008
    ..Two-photon excitation fluorescence microscope is a useful tool for studying 5-ALA-induced PpIX subcellular localization...
  18. ncbi Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    FASEB J 20:2651-3. 2006
    ..Because CoPP, unlike heme, is neither a prooxidant nor a substrate for HO-1, it might be considered as a potential therapeutic agent in situations where up-regulation of HO-1 is desired...
  19. ncbi Zinc protoporphyrin: A metabolite with a mission
    R F Labbe
    Department of Laboratory Medicine, Box 359743, University of Washington, Seattle, WA 98104, USA
    Clin Chem 45:2060-72. 1999
    ..Biochemical research techniques, both in vivo and in vitro, are described for further studies into the role of ZnPP in metabolism and physiology...
  20. ncbi Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX
    Alicja Jozkowicz
    Department of Vascular Surgery, University of Vienna, Austria
    Antioxid Redox Signal 5:155-62. 2003
    ..Thus, HO activity up-regulates VEGF production and augments the capability of endothelial cells to respond to exogenous stimulation...
  21. ncbi Photobleaching kinetics, photoproduct formation, and dose estimation during ALA induced PpIX PDT of MLL cells under well oxygenated and hypoxic conditions
    Jonathan S Dysart
    Juravinski Cancer Centre, Physics Research, 699 Concession St, Hamilton, Ontario, Canada
    Photochem Photobiol Sci 5:73-81. 2006
    ....
  22. ncbi Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cell
    Chung Wook Chung
    Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Eur J Pharm Biopharm 80:453-8. 2012
    ..Cotreatment with the surfactant resulted in an increased intracellular ALA level, PpIX formation, and phototoxicity...
  23. pmc Nanoscopic micelle delivery improves the photophysical properties and efficacy of photodynamic therapy of protoporphyrin IX
    Huiying Ding
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Control Release 151:271-7. 2011
    ..e. 4% PpIX-conjugated micelles) for in vivo evaluation of antitumor efficacy...
  24. ncbi Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells
    Shu Jyuan Yang
    Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10051, Taiwan
    Bioconjug Chem 21:679-89. 2010
    ..Therefore, the folic acid-chitosan conjugate appears to be an ideal vector for colorectal-specific delivery of 5-ALA for fluorescent endoscopic detection...
  25. pmc Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact
    Sylvie Létoffé
    Unité des Membranes Bactériennes, Departement de Microbiologie, Institut Pasteur, CNRS URA 2172, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 106:11719-24. 2009
    ..YfeX and EfeB are widespread and highly conserved in bacteria. We propose that their physiological function is to retrieve iron from heme...
  26. ncbi Novel patch-based systems for the localised delivery of ALA-esters
    Desmond I J Morrow
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Photochem Photobiol B 101:59-69. 2010
    ..In addition, owing to the relatively low loadings of h-ALA required in PSA patches, the costs of clinical PDT may potentially be reduced...
  27. ncbi Induction of sonodynamic effect with protoporphyrin IX on isolate hepatoma-22 cells
    Na Mi
    College of Life Sciences, Shaanxi Normal University, 199 Chang An South Road, Xi an, Shaanxi, China
    Ultrasound Med Biol 35:680-6. 2009
    ..16% in SDT-treated group). These results indicated that the ultrasonically-induced cell killing effect could be enhanced by PpIX, and that the mitochondrial pathway might be involved in the cell damage process...
  28. ncbi Detection of metastatic lymph nodes using 5-aminolevulinic acid in patients with gastric cancer
    Noriaki Koizumi
    Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Ann Surg Oncol 20:3541-8. 2013
    ....
  29. pmc Functional definition of the tobacco protoporphyrinogen IX oxidase substrate-binding site
    Ilka U Heinemann
    Institute of Microbiology, Technical University Braunschweig, Spielmannstr 7, 38106 Braunschweig, Germany
    Biochem J 402:575-80. 2007
    ..Therefore tobacco PPO2 represents a useful model system for the understanding of the structure-function relationship underlying detrimental human enzyme defects...
  30. ncbi Comparison of pharmacokinetics, intracellular localizations and sonodynamic efficacy of endogenous and exogenous protoporphyrin IX in sarcoma 180 cells
    Xiaobing Wang
    Key Laboratory of Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Shaanxi, Xi an, China
    Ultrasonics 50:803-10. 2010
    ....
  31. ncbi Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
    Tzong Shyuan Lee
    Graduate Institute of Life Sciences, National Defense Medical Center, and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    Nat Med 8:240-6. 2002
    ..The identification of HO-1 as a downstream effector of IL-10 provides new possibilities for improved therapeutic approaches for treating inflammatory diseases...
  32. pmc Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells
    Cy Hyun Kim
    National Research and Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Int J Nanomedicine 6:1357-63. 2011
    ..Furthermore, an increased amount of PpIX in HuCC-T1 cells induced increased production of ROS by irradiation, resulting in increased phototoxicity...
  33. pmc δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy
    Pablo A Valdes
    Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire, USA
    Neuro Oncol 13:846-56. 2011
    ..This work suggests a need for improved PpIX fluorescence detection technologies to achieve better sensitivity and quantification of PpIX in tissue during surgery...
  34. pmc The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells
    K Berg
    Institute for Cancer Research, Department of Biophysics, Montebello, Norway
    Br J Cancer 74:688-97. 1996
    ..The ferrochelatase inhibitor dihydropyridine 3,5-diethoxycarbonyl-1,4-dihydrocollidine reduced the accumulation of PpIX in both cell lines...
  35. pmc Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth
    K Doi
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Br J Cancer 80:1945-54. 1999
    ..In conclusion, HO-1 expression in the solid tumour may confer resistance of tumour cells to hypoxic stress as well as to NO-mediated cytotoxicity...
  36. ncbi Prevalence of iron deficiency with and without concurrent anemia in population groups with high prevalences of malaria and other infections: a study in Côte d'Ivoire
    F S Asobayire
    Laboratory of Human Nutrition, the Institute of Food Science, Swiss Federal Institute of Technology, , Switzerland
    Am J Clin Nutr 74:776-82. 2001
    ..The serum transferrin receptor is the most useful single indicator of iron deficiency because it was the only iron-status index unaffected by malaria or inflammation...
  37. ncbi Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture
    Masatoshi Ohnishi
    Department of Pharmacotherapeutics, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Gakuencho 1, Fukuyama, Hiroshima 729 0292, Japan
    Brain Res 1347:170-8. 2010
    ..Thrombin-induced cortical injury may be also regulated by the expression of HO-1 and the resultant production of heme degradation products such as carbon monoxide...
  38. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    ..Our findings have implications for the survival of stem cells and tumor cells in hypoxic environments...
  39. ncbi The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria
    Tamara Azarashvili
    Institut fur Neurobiochemie, Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Cell Calcium 42:27-39. 2007
    ..This study provides evidence for PBR involvement in PTP opening, controlling the Ca2+-induced Ca2+ efflux, and AIF release from mitochondria, important stages of initiation of programmed cell death...
  40. ncbi Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937
    Takashi Amo
    Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cell Biochem Funct 27:503-15. 2009
    ..These results indicated that ALA-based-PDA induced apoptotic cell death through a mitochondrial pathway and that ferrochelatase inhibitors might enhanced the effect of PDT for tumors even at low concentrations of ALA...
  41. ncbi Heme oxygenase-1 prevents hyperthyroidism induced hepatic damage via an antioxidant and antiapoptotic pathway
    Murat Giris
    Department of Biochemistry, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
    J Surg Res 164:266-75. 2010
    ..We aimed to investigate the pathogenesis of liver dysfunction caused by hyperthyroidism through inducing heme oxygenase-1 (HO-1) expression, which has antioxidant and anti-apoptotic properties...
  42. ncbi 5-Aminolevulinic acid-induced protoporphyrin-IX accumulation and associated phototoxicity in macrophages and oral cancer cell lines
    Sulbha Sharma
    Laser Biomedical Applications and Instrumentation Division, Raja Ramanna Center for Advanced Technology, R and D BLOCK D, Indore 452 013, India
    J Photochem Photobiol B 88:156-62. 2007
    ..Since macrophages are responsible for production and secretion of various tumor growth mediators, the effect of selective macrophage killing on the outcome of PDT would be significant...
  43. ncbi Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells
    Tetsuya Ogino
    Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata, Okayama 700 8558, Japan
    Mol Cell Biochem 358:297-307. 2011
    ..Inhibition of ABCG2 transporter system could be a new target for the improvement of photodynamic therapy...
  44. ncbi Fisetin induces Nrf2-mediated HO-1 expression through PKC-δ and p38 in human umbilical vein endothelial cells
    Seung Eun Lee
    Department of Microbiology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
    J Cell Biochem 112:2352-60. 2011
    ..In summary, these findings suggest that induction of HO-1 expression via Nrf2 activation may contribute to the cytoprotection exerted by fisetin against H(2)O(2) -induced oxidative stress in HUVECs...
  45. ncbi Prolonged allogeneic islet graft survival by protoporphyrins
    Antonello Pileggi
    Cell Transplant Center, Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10th Avenue R 134, Miami, FL 33136, USA
    Cell Transplant 14:85-96. 2005
    ..We tested the effect of the use of protoporphyrins (CoPP and FePP), powerful inducers of the cytoprotective protein heme-oxygenase 1 (HO-1), on allogeneic islet ..
  46. pmc Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma
    D Ickowicz Schwartz
    Faculty of Life Science, Bar Ilan University, Ramat Gan 52900, Israel
    Br J Cancer 90:1833-41. 2004
    ..We suggest that efficient photodynamic therapy of cancer facilitated by ALA administration can be enhanced using combined therapeutic modalities...
  47. pmc Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats
    Fei Wang
    Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
    World J Gastroenterol 15:3009-14. 2009
    ..To investigate the effect of heme oxygenase-1 (HO-1) expression on immune liver fibrosis induced by cobalt protoporphyrin (CoPP) in rats...
  48. ncbi ALA and its clinical impact, from bench to bedside
    Barbara Krammer
    University of Salzburg, Department of Molecular Biology, Austria
    Photochem Photobiol Sci 7:283-9. 2008
    ..Pharmacokinetical studies have demonstrated a low systemic photosensitivity and excretion of PpIX via natural routes...
  49. ncbi The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1
    Stefanie Grimm
    Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Strasse 24, Jena, Germany
    Biofactors 37:17-24. 2011
    ..However, further studies are necessary to investigate more antioxidants and other substances, which might affect the outcome of photodynamic treatment in cancer therapy...
  50. ncbi Subcellular localization pattern of protoporphyrin IX is an important determinant for its photodynamic efficiency of human carcinoma and normal cell lines
    Zhenyu Ji
    Department of Pathology, The National Hospital Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 84:213-20. 2006
    ..Our finding suggests that future new photosensitizers with mitochondrially localizing properties may be designed for effective PDT...
  51. ncbi Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes
    Saadet Turkseven
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 289:H701-7. 2005
    ..These observations in experimental diabetes suggest that the vascular cytoprotective mechanism of HO-1 against oxidative stress requires an increase in EC-SOD and catalase...
  52. pmc Identification of a plastid response element that acts as an enhancer within the Chlamydomonas HSP70A promoter
    Erika D von Gromoff
    Institut fur Biologie III, Lehrstuhl Biochemie der Pflanzen, Universitat Freiburg, Schaenzlestrasse 1 D 79104, Freiburg, Germany
    Nucleic Acids Res 34:4767-79. 2006
    ..This cis-acting sequence element is employed for induction of HSP70A by both MgProto and light, lending support to the model that light induction of this gene is mediated via MgProto...
  53. ncbi Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway
    Masamichi Katori
    Division of Liver and Pancreas Transplantation, Dumot UCLA Transplant Center, Los Angeles, California 90095, USA
    Transplantation 73:287-92. 2002
    ..We report on the cytoprotective effects of HO-1 in a rat cardiac I/R injury model, using cobalt protoporphyrin (CoPP) as HO-1 inducer and zinc protoporphyrin (ZnPP) as HO-1 inhibitor...
  54. ncbi Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries
    D A Tulis
    Department of Medicine, Baylor College of Medicine, 6550 Fannin, SM MS 1423, Houston, TX 77030, USA
    Atherosclerosis 155:113-22. 2001
    ..These results directly implicate HO-1 and the products of heme catabolism in attenuating the arterial response to injury and ensuing vascular wall remodeling...
  55. ncbi Identification of a mammalian mitochondrial porphyrin transporter
    Partha C Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    Nature 443:586-9. 2006
    ..This process is blocked when the Abcb6 gene is silenced. Our results challenge previous assumptions about the intracellular movement of porphyrins and the factors controlling haem biosynthesis...
  56. ncbi GUN4, a regulator of chlorophyll synthesis and intracellular signaling
    Robert M Larkin
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 299:902-6. 2003
    ..GUN4 binds the product and substrate of Mg- chelatase, an enzyme that produces Mg-Proto, and activates Mg-chelatase. Thus, GUN4 participates in plastid-to-nucleus signaling by regulating Mg-Proto synthesis or trafficking...
  57. ncbi Chloroplast to nucleus communication triggered by accumulation of Mg-protoporphyrinIX
    Asa Strand
    Plant Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Nature 421:79-83. 2003
    ..Accumulation of Mg-ProtoIX is both necessary and sufficient to regulate the expression of many nuclear genes encoding chloroplastic proteins associated with photosynthesis...
  58. pmc Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells
    A Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Cell Mol Biol (Noisy-le-grand) 51:347-55. 2005
    ..Our data show that although both CoCl2 and CoPPIX induce HO-1, the influence of CoCl2 on VEGF does not involve HO-1 and is HIF-1-dependent, while the effect of CoPPIX does not involve HIF-1 but relies on HO-1...
  59. pmc Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells
    A K Sinha
    Department of Dermatology, Wellman Center for Photomedicine, Harvard Medical School, Boston, MA 02114, USA
    Br J Cancer 95:485-95. 2006
    ..Our data suggest that MTX, when used to modulate intracellular production of endogenous PpIX, may provide a new combination PDT approach for certain cancers...
  60. ncbi Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin
    Gary A Visner
    Department of Pediatrics, College of Medicine, University of Florida, Gainesville 32610, USA
    Circulation 107:911-6. 2003
    ..Heme oxygenase-1 (HO-1) has also been shown to have graft protective effects and to inhibit vascular remodeling. In this study, we evaluated whether there is an interaction between rapamycin and HO-1...
  61. ncbi Anticancer effect of photodynamic therapy with hexenyl ester of 5-aminolevulinic acid in oral squamous cell carcinoma
    Yeon Hee Moon
    Department of Pathology, School of Dentistry, Chosun University, Gwangju 501 759, Korea
    Head Neck 32:1136-42. 2010
    ..In this study, the effect of photodynamic therapy (PDT) with hexenyl ester of ALA (ALA-hx) was examined in a human oral squamous cell carcinoma, YD10B cells...
  62. pmc Laparoscopic fluorescence diagnosis for intraabdominal fluorescence targeting of peritoneal carcinosis experimental studies
    Johannes Gahlen
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 235:252-60. 2002
    ..To assess 5-aminolevulinic acid (ALA)-induced protoporphyrin IX accumulation and fluorescence in peritoneal colon carcinoma metastases and its benefits for laparoscopic fluorescence diagnosis...
  63. ncbi Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface
    Andre Sollwedel
    Reproductive Immunology Group, Institute of Medical Immunology, Biomedizinisches Forschungszentrum BMFZ, Charité Medical University of Berlin, Germany
    J Immunol 175:4875-85. 2005
    ..e., Bag-1, and by activating T regulatory cells rather than by changing the local cytokine profile...
  64. ncbi Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer
    Wolfgang Kemmner
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Str 10, 13125 Berlin, Germany
    FASEB J 22:500-9. 2008
    ..Furthermore, accumulation of intracellular PpIX because of FECH siRNA silencing provides a small-molecule-based approach to molecular imaging and molecular therapy...
  65. ncbi Heme oxygenase-1 attenuates contact hypersensitivity induced by 2,4-dinitrofluorobenzene in mice
    Hyun Ock Pae
    Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Republic of Korea
    Immunopharmacol Immunotoxicol 30:207-16. 2008
    ..Our findings suggest that HO-1 plays an important role in CHS and is an important pharmacological target for the treatment of CHS...
  66. ncbi Clinical pharmacokinetics of 5-aminolevulinic acid in healthy volunteers and patients at high risk for recurrent bladder cancer
    James T Dalton
    Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Pharmacol Exp Ther 301:507-12. 2002
    ..Regional administration (i.e., intravesical) of ALA resulted in a significant pharmacokinetic advantage, with urinary bladder being exposed to concentrations approximately 20,000-fold higher than systemic circulation...
  67. ncbi Cobalt-protoporphyrin induced heme oxygenase overexpression and its impact on liver regeneration
    M Glanemann
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Transplant Proc 37:3223-5. 2005
    ..Thus, it is conceivable that prevention of ischemia-reperfusion injury by HO-1 overexpression also might be beneficial for reduced-size liver grafts without affecting their proliferative capacity...
  68. ncbi Lack of association of delta-aminolevulinic acid dehydratase genotype with cytogenetic damage in lead workers
    Fang Yang Wu
    Institute of Environmental Health, China Medical University, 91 Hsueh Shin Road, Taichung, Taiwan
    Int Arch Occup Environ Health 77:395-400. 2004
    ....
  69. ncbi Photodetection of basal cell carcinoma using methyl 5-aminolaevulinate-induced protoporphyrin IX based on fluorescence image analysis
    Y Won
    Department of Dermatology, Chonnam National University, Gwangju, Korea
    Clin Exp Dermatol 32:423-9. 2007
    ..Hence, epithelial tumours, including basal cell carcinoma (BCC), might be visualized using the fluorescence of selectively accumulated ALA-induced PpIX...
  70. pmc Fluorescence tomography characterization for sub-surface imaging with protoporphyrin IX
    Dax Kepshire
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Opt Express 16:8581-93. 2008
    ....
  71. ncbi Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner
    Joanna Zawacka-Pankau
    Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk, Kladki 24, 80 822 Poland
    J Biol Chem 282:2466-72. 2007
    ..PDT treatment (2 J/cm2) of HCT116 cells induced p53-dependent activation of pro-apoptotic gene expression followed by growth suppression and induction of apoptosis...
  72. ncbi Endoscopic identification and biopsy sampling of an intraventricular malignant glioma using a 5-aminolevulinic acid-induced protoporphyrin IX fluorescence imaging system. Technical note
    Yoji Tamura
    Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan
    J Neurosurg 106:507-10. 2007
    ..Several biopsy specimens obtained from the fluorescent lesion provided a definitive histological diagnosis. The results indicate that this endoscopic system is useful in detecting an intraventricular fluorescent tumor...
  73. ncbi Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR
    N G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Cell Mol Biol (Noisy-le-grand) 48:895-902. 2002
    ....
  74. ncbi Photodynamic therapy of human glioma spheroids using 5-aminolevulinic acid
    S J Madsen
    Department of Health Physics, University of Nevada, Las Vegas 89154 3037, USA
    Photochem Photobiol 72:128-34. 2000
    ..The fluence rate effect is not as pronounced at higher fluences (> 50 J cm-2), where a favorable response is observed throughout the range of fluence rates investigated. The clinical implications of these findings are discussed...
  75. pmc Zinc protoporphyrin IX binds heme crystals to inhibit the process of crystallization in Plasmodium falciparum
    Jayasree K Iyer
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Department of International Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Mol Med 9:175-82. 2003
    ..In endemic malaria areas, severe iron deficiency anemia should be treated with antimalarials along with iron replenishment...
  76. ncbi Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins
    Ying Shan
    Department of Medicine, and the The Liver Biliary Pancreatic Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Arch Biochem Biophys 399:159-66. 2002
    ..We conclude that the chick HO-1 promoter region contains a unique sequence that subserves up-regulation of the gene by metalloporphyrins and propose the name "metalloporphyrin-responsive element" for this sequence...
  77. ncbi Endoscopic fluorescence detection of intraepithelial neoplasia in Barrett's esophagus after oral administration of aminolevulinic acid
    T Stepinac
    Institute of Environmental Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland
    Endoscopy 35:663-8. 2003
    ..This study evaluates endoscopic fluorescence detection in patients having Barrett's esophagus and compares the results to those of standard endoscopy with random four-quadrant biopsies...
  78. ncbi Fluorescence detection and depletion of T47D breast cancer cells from human mononuclear cell-enriched blood preparations by photodynamic treatment: Basic in vitro experiments towards the removal of circulating tumor cells
    Verena G Ziegler
    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
    Lasers Surg Med 43:548-56. 2011
    ..This study aims at providing basic evidence towards fluorescence detection and photodynamic depletion of scattered cancer cells from blood preparations...
  79. ncbi In vivo uptake of a haem analogue Zn protoporphyrin IX by the human malaria parasite P. falciparum-infected red blood cells
    Robson Sartorello
    Departamento de Fisiologia, Instituto de Biocincias, Universidade de So Paulo, 05508900 São Paulo, SP, Brazil
    Cell Biol Int 34:859-65. 2010
    ....
  80. ncbi Improved peptide prodrugs of 5-ALA for PDT: rationalization of cellular accumulation and protoporphyrin IX production by direct determination of cellular prodrug uptake and prodrug metabolization
    Francesca Giuntini
    Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U K
    J Med Chem 52:4026-37. 2009
    ..In agreement with PpIX fluorescence studies, at a concentration of 0.1 mM, l-Phe derivatives 4m and 4o, and l-Leu, l-Met, and l-Glu derivatives 4f, 4k, and 4u, exhibit significantly enhanced photoxicity in PAM212 cells compared to ALA...
  81. ncbi Study of cell killing effect on S180 by ultrasound activating protoporphyrin IX
    Xiao Bing Wang
    College of Life Sciences, Shaanxi Normal University, Xi an 710062, China
    Ultrasonics 48:135-40. 2008
    ..This biological mechanism might be involved in mediating the effects on S180 cells and resulting in the cell damage seen with SDT...
  82. ncbi Intraclutch variation in avian eggshell pigmentation: the anaemia hypothesis
    Greet De Coster
    Department of Biology, Terrestrial Ecology Unit, Ghent University, Ghent, Belgium
    Oecologia 170:297-304. 2012
    ..However, the overall increase in pigment darkness along the laying sequence suggests that pigments also accumulate by enhanced red blood cell production caused by anaemia due to egg production itself...
  83. pmc A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery
    P A Valdes
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 37:1817-9. 2012
    ..The simplicity of the method lends itself to the enticing prospect that the method could be applicable to wide-field applications in quantitative fluorescence imaging and dosimetry in photodynamic therapy...
  84. ncbi Targeting of p53 and its homolog p73 by protoporphyrin IX
    Alicja Sznarkowska
    Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
    FEBS Lett 585:255-60. 2011
    ..We propose that PpIX disrupts the p53/MDM2 or MDMX and p73/MDM2 complexes and thereby activates the p53- or p73-dependent cancer cell death...
  85. ncbi The weight loss elicited by cobalt protoporphyrin is related to decreased activity of nitric oxide synthase in the hypothalamus
    Muyao Li
    Department of Medicine, University of Vermont, C209 Given Bldg, 89 Beaumont Ave, Burlington, Vermont 05405, USA
    J Appl Physiol (1985) 100:1983-91. 2006
    ..We also demonstrate that CoPP decreases NOS activity but that it paradoxically increases neuronal NOS transcript expression and increases neuronal NOS protein content on Western blotting...
  86. ncbi Relation between intracellular location and photodynamic efficacy of 5-aminolevulinic acid-induced protoporphyrin IX in vitro. Comparison between human glioblastoma cells and other cancer cell lines
    Reinhard Sailer
    Institut fur Lasertechnologien in der Medizin und Messtechnik an der Universitat Ulm, Helmholtzstr 12, 89081, Ulm, Germany
    Photochem Photobiol Sci 6:145-51. 2007
    ....
  87. ncbi The centrality of PBGD expression levels on ALA-PDT efficacy
    Avital Schauder
    Microscopy Unit, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, 52900, Israel
    Photochem Photobiol Sci 10:1310-7. 2011
    ..This enables efficient ALA-PDT, even when PBGD is not fully active. Conversely, ALAD loss resulted in reduced PpIX synthesis and consequently failure in ALA-PDT, due to the absence of compensation mechanism for ALAD...
  88. pmc Comparison of delta-aminolaevulinic acid and its methyl ester as an inducer of porphyrin synthesis in cultured cells
    R Washbrook
    Department of Molecular Pathology, UCL Medical School, London, UK
    Br J Cancer 75:1417-20. 1997
    ..6% in ALA-treated cells with a corresponding reduction in cell-associated PPIX (P < 0.05). A variable initial elevation in haem levels in ALA-ME-treated cells was observed, but did not reach statistically significant levels...
  89. ncbi The anti-inflammatory role of heme oxygenase-1 in lipopolysaccharide and cytokine-stimulated inducible nitric oxide synthase and nitric oxide production in human periodontal ligament cells
    Young Suk Kim
    Department of Oral and Maxillofacial Pathology, College of Dentistry, Wonkwang University, Iksan, South Korea
    J Periodontol 80:2045-55. 2009
    ....
  90. ncbi Quinolone compounds enhance delta-aminolevulinic acid-induced accumulation of protoporphyrin IX and photosensitivity of tumour cells
    Yoshiko Ohgari
    Department of Biotechnology, Kyoto Institute of Technology, Kyoto, Japan
    J Biochem 149:153-60. 2011
    ..Hence, we now propose that the use of quinolones in combination with ALA may be an extremely effective approach for the treatment modalities for PDT of various tumour tissues in clinical practice...
  91. pmc Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model
    J Bedwell
    Department of Surgery, University College London, UK
    Br J Cancer 65:818-24. 1992
    ..There is also a greater concentration difference between the PP IX levels in tumours and in normal mucosa and normal muscle than with the other photosensitisers raising the possibility of more selective necrosis in tumours...
  92. pmc Zinc protoporphyrin regulates cyclin D1 expression independent of heme oxygenase inhibition
    Ping La
    Division of Neonatology, Children s Hospital of Philadelphia, PA 19104, USA
    J Biol Chem 284:36302-11. 2009
    ..These observations show HO independent effects of ZnPP on cyclin D1 expression and tumorigenesis...
  93. ncbi Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity
    Markus Biburger
    Nikolaus Fiebiger Center for Molecular Medicine, Medical Department III, University Hospital of Erlangen, Germany
    J Leukoc Biol 87:193-202. 2010
    ..In summary, these data suggest that HO-1 expression by T(regs) might contribute to their typical reluctance to proliferate but does not account independently for their suppressive functions...
  94. ncbi Protoporphyrin IX binding and transport by recombinant mouse PBR
    Gregor Wendler
    Division of Hormone Research, Departments of Cell Biology, Pharmacology and Neurosciences, Georgetown University School of Medicine, 3900 Reservoir Road, NW, Washington, DC, USA
    Biochem Biophys Res Commun 311:847-52. 2003
    ..These results suggest that PBR, in addition to its role in cholesterol and coproporphyrinogen III transport, is also directing the mitochondrial PPIX import, a function that can be ascribed to the 18kDa PBR protein alone...
  95. ncbi Amitrole treatment of etiolated barley seedlings leads to deregulation of tetrapyrrole synthesis and to reduced expression of Lhc and RbcS genes
    N La Rocca
    Dipartimento di Biologia, , Italy
    Planta 213:101-8. 2001
    ....
  96. ncbi Expression of haem oxygenase in cirrhotic rat liver
    Chang Li Wei
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260
    J Pathol 199:324-34. 2003
    ..Induction of HO-1 may be mediated partially by iNOS. However, once it is induced, HO-1 may be important in modulating iNOS activity, thus playing a protective role in liver cirrhosis...
  97. ncbi Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy
    Hiroto Inoue
    Department of Neurosurgery, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, Japan
    J Neurooncol 83:223-31. 2007
    ..This finding implies that ALA-PDT is a promising therapy for the treatment of apoptosis-reluctant tumors such as malignant gliomas...
  98. ncbi Pharmacological preconditioning with doxorubicin. Implications of heme oxygenase-1 induction in doxorubicin-induced hepatic injury in rats
    K Ito
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, 101-0062, Tokyo, Japan
    Biochem Pharmacol 62:1249-55. 2001
    ..These results strongly suggest that pharmacological preconditioning with DOX may generally help to attenuate subsequent oxidant-induced hepatic injury...
  99. pmc A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin
    John W Smalley
    Unit of Basic Dental Science, Department of Clinical Dental Sciences, University of Liverpool, The Edwards Building, Daulby Street, Liverpool L69 3GN, UK
    Biochem J 379:833-40. 2004
    ..These results show that one or both of RgpA and RgpB gingipains, in addition to the lysine-specific gingipain, is necessary for the production of mu-oxo bishaem from haemoglobin by whole cells of P. gingivalis...
  100. ncbi The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes micro-oxo bishaem formation from monomeric iron(III) protoporphyrin IX
    J W Smalley
    The University of Liverpool, Oral Microbiology Group, Department of Clinical Dental Sciences, The Edwards Building, Daulby Street, Liverpool L69 3GN, UK
    Microbiology 152:1839-45. 2006
    ..It is concluded that the Arg- and Lys-gingipains with HA2 haemagglutinin domains may play a crucial role in haem-pigment formation by converting Fe(III)PPIX.OH monomers into [Fe(III)PPIX]2O and promoting their aggregation...
  101. pmc Tetrapyrrole profiling in Arabidopsis seedlings reveals that retrograde plastid nuclear signaling is not due to Mg-protoporphyrin IX accumulation
    Michael Moulin
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 105:15178-83. 2008
    ..Instead, it is possible that a perturbation of tetrapyrrole synthesis may lead to localized ROS production or an altered redox state of the plastid, which could mediate retrograde signaling...

Research Grants31

  1. Clinical and Molecular Studies of the Erythropoietic Protoporphyria Phenotype
    Manisha Balwani; Fiscal Year: 2013
    ..erythroid-specific d- aminolevulinate synthase (ALAS2) gene, and 3) a subtype with elevated erythrocyte protoporphyrins, cutaneous photosensitivity, and normal FECH and ALAS2 alleles...
  2. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  3. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  4. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..heme uptake pathways will have a great impact in understanding disorders associated with iron overload (hereditary hemochromatosis, iron overload secondary to blood transfusions) and nutritional iron deficiency [unreadable] [unreadable]..
  5. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2007
    ..abstract_text> ..
  6. NUTRITIONAL & METABOLIC REGULATION OF BODY WEIGHT
    RICHARD GALBRAITH; Fiscal Year: 2003
    ..abstract_text> ..
  7. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  8. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  9. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  10. Heme oxygenase and cerebral vascular injury
    Helena Parfenova; Fiscal Year: 2008
    ..Better understanding of the mechanisms of postictal cerebral vascular dysfunction is needed to improve the long-term neurological outcome in human newborns. ..
  11. Development of neuromuscular junctions in children with cerebral palsy
    Robert Akins; Fiscal Year: 2008
    ..The PIs study these interactions in order to develop therapies and treatments that will improve and sustain the physical ability and health of patients with CP. [unreadable] [unreadable] [unreadable]..
  12. FUNCTIONAL SIGNIFICANCE OF EARLY IRON DEFICIENCY
    Betsy Lozoff; Fiscal Year: 2008
    ..abstract_text> ..
  13. Anemia in the Elderly: Pathogenesis
    Jeffrey S Friedman; Fiscal Year: 2010
    ..If such differences also occur among controls they could account for the broad normal variation in hemoglobin levels. ..
  14. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  15. Hemolytic Anemia: Biochemical, Molecular and Proteomic Diagnostics
    Jeffrey S Friedman; Fiscal Year: 2010
    ..We are pursuing these studies to try to find the cause of this disorder for the large group of patients for whom we can currently provide no specific diagnosis. ..
  16. Pharmacology of Nonsteroidal Androgen Receptor Ligands
    James Dalton; Fiscal Year: 2007
    ..e., the ability to maintain prostate and muscle size) are a result of differences in pharmacologic potency, tissue amplification (e.g., 5a-reductase), or drug exposure. ..
  17. C/EDB BETA AND CHOP IN EPIDERMAL DIFFERENTIATION
    Edward Maytin; Fiscal Year: 2002
    ....
  18. ENZYME DEFECTS IN DISORDERS OF PROTOPORPHYRIN METABOLISM
    Joseph Bloomer; Fiscal Year: 2005
    ..The proposal thus is designed to define a critical relationship between FECH gene expression and phenotype in EPP which will lead to better genetic counseling and therapy. ..
  19. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  20. Ultraviolet-C Therapy for Onychomycosis
    MICHAEL HAMBLIN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  21. Pathogenesis and Therapy of Sideroblastic Anemia
    Jeffrey Friedman; Fiscal Year: 2007
    ....
  22. HYALURONAN AND EPIDERMAL DIFFERENTIATION
    Edward Maytin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  24. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2004
    ....
  25. DIGE Package: Variable Mode Imager and Spot Picker
    Jeffrey Friedman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ....
  27. Improving Survival For Small-For-Size Liver Grafts
    Zhi Zhong; Fiscal Year: 2004
    ..This work will develop mechanism-based strategies to increase the use and improve the outcome of partial livers for transplantation in the clinic. ..
  28. Mechanisms of In Vivo Ethanol-Induced Mitochondrial Depolarization
    Zhi Zhong; Fiscal Year: 2010
    ....
  29. MYOCARDIAL PRESERVATION DURING ISCHEMIC ARREST
    DIPAK DAS; Fiscal Year: 2009
    ..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
  30. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2008
    ..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. [unreadable] [unreadable]..
  31. PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURY
    DIPAK DAS; Fiscal Year: 2009
    ....