protoporphyrins

Summary

Summary: Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.

Top Publications

  1. ncbi Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma
    D Ickowicz Schwartz
    Faculty of Life Science, Bar Ilan University, Ramat Gan 52900, Israel
    Br J Cancer 90:1833-41. 2004
  2. ncbi Prolonged allogeneic islet graft survival by protoporphyrins
    Antonello Pileggi
    Cell Transplant Center, Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10th Avenue (R-134, Miami, FL 33136, USA
    Cell Transplant 14:85-96. 2005
  3. ncbi Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats
    Fei Wang
    Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
    World J Gastroenterol 15:3009-14. 2009
  4. ncbi The CHLI1 subunit of Arabidopsis thaliana magnesium chelatase is a target protein of the chloroplast thioredoxin
    Akinori Ikegami
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Yokohama 226 8501, Japan
    J Biol Chem 282:19282-91. 2007
  5. ncbi Pharmacological preconditioning with doxorubicin. Implications of heme oxygenase-1 induction in doxorubicin-induced hepatic injury in rats
    K Ito
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, 101-0062, Tokyo, Japan
    Biochem Pharmacol 62:1249-55. 2001
  6. ncbi Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy
    Jürgen Frank
    zet Life Science Laboratory Linz, 4020, Linz, Austria
    Int J Oncol 31:1539-45. 2007
  7. ncbi Kinetics and subcellular localization of 5-ALA-induced PpIX in DHL cells via two-photon excitation fluorescence microscopy
    Rong Chen
    Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou, Fujian 350007, PR China
    Int J Oncol 32:861-7. 2008
  8. ncbi Expression of haem oxygenase in cirrhotic rat liver
    Chang-Li Wei
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260
    J Pathol 199:324-34. 2003
  9. ncbi The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1
    Stefanie Grimm
    Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Strasse 24, Jena, Germany
    Biofactors 37:17-24. 2011
  10. ncbi A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin
    John W Smalley
    Unit of Basic Dental Science, Department of Clinical Dental Sciences, University of Liverpool, The Edwards Building, Daulby Street, Liverpool L69 3GN, UK
    Biochem J 379:833-40. 2004

Research Grants

  1. STRUCTURE/FUNCTION AND REACTION MECHANISM OF PGHS
    Ah Lim Tsai; Fiscal Year: 2002
  2. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2009
  3. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
  4. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
  5. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
  6. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra Juul; Fiscal Year: 2009
  7. NUTRITIONAL & METABOLIC REGULATION OF BODY WEIGHT
    RICHARD GALBRAITH; Fiscal Year: 2003
  8. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
  9. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2010
  10. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra E Juul; Fiscal Year: 2010

Detail Information

Publications189 found, 100 shown here

  1. ncbi Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma
    D Ickowicz Schwartz
    Faculty of Life Science, Bar Ilan University, Ramat Gan 52900, Israel
    Br J Cancer 90:1833-41. 2004
    ..We suggest that efficient photodynamic therapy of cancer facilitated by ALA administration can be enhanced using combined therapeutic modalities...
  2. ncbi Prolonged allogeneic islet graft survival by protoporphyrins
    Antonello Pileggi
    Cell Transplant Center, Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10th Avenue (R-134, Miami, FL 33136, USA
    Cell Transplant 14:85-96. 2005
    ..We tested the effect of the use of protoporphyrins (CoPP and FePP), powerful inducers of the cytoprotective protein heme-oxygenase 1 (HO-1), on allogeneic islet ..
  3. ncbi Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats
    Fei Wang
    Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
    World J Gastroenterol 15:3009-14. 2009
    ..To investigate the effect of heme oxygenase-1 (HO-1) expression on immune liver fibrosis induced by cobalt protoporphyrin (CoPP) in rats...
  4. ncbi The CHLI1 subunit of Arabidopsis thaliana magnesium chelatase is a target protein of the chloroplast thioredoxin
    Akinori Ikegami
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Yokohama 226 8501, Japan
    J Biol Chem 282:19282-91. 2007
    ..Our findings strongly suggest that chlorophyll biosynthesis is subject to chloroplast biogenesis regulation networks to coordinate them with the photosynthetic pathways in chloroplasts...
  5. ncbi Pharmacological preconditioning with doxorubicin. Implications of heme oxygenase-1 induction in doxorubicin-induced hepatic injury in rats
    K Ito
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, 101-0062, Tokyo, Japan
    Biochem Pharmacol 62:1249-55. 2001
    ..These results strongly suggest that pharmacological preconditioning with DOX may generally help to attenuate subsequent oxidant-induced hepatic injury...
  6. ncbi Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy
    Jürgen Frank
    zet Life Science Laboratory Linz, 4020, Linz, Austria
    Int J Oncol 31:1539-45. 2007
    ....
  7. ncbi Kinetics and subcellular localization of 5-ALA-induced PpIX in DHL cells via two-photon excitation fluorescence microscopy
    Rong Chen
    Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou, Fujian 350007, PR China
    Int J Oncol 32:861-7. 2008
    ..Two-photon excitation fluorescence microscope is a useful tool for studying 5-ALA-induced PpIX subcellular localization...
  8. ncbi Expression of haem oxygenase in cirrhotic rat liver
    Chang-Li Wei
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260
    J Pathol 199:324-34. 2003
    ..Induction of HO-1 may be mediated partially by iNOS. However, once it is induced, HO-1 may be important in modulating iNOS activity, thus playing a protective role in liver cirrhosis...
  9. ncbi The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1
    Stefanie Grimm
    Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Strasse 24, Jena, Germany
    Biofactors 37:17-24. 2011
    ..However, further studies are necessary to investigate more antioxidants and other substances, which might affect the outcome of photodynamic treatment in cancer therapy...
  10. ncbi A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin
    John W Smalley
    Unit of Basic Dental Science, Department of Clinical Dental Sciences, University of Liverpool, The Edwards Building, Daulby Street, Liverpool L69 3GN, UK
    Biochem J 379:833-40. 2004
    ..These results show that one or both of RgpA and RgpB gingipains, in addition to the lysine-specific gingipain, is necessary for the production of mu-oxo bishaem from haemoglobin by whole cells of P. gingivalis...
  11. ncbi Chloroplast to nucleus communication triggered by accumulation of Mg-protoporphyrinIX
    Asa Strand
    Plant Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Nature 421:79-83. 2003
    ..Accumulation of Mg-ProtoIX is both necessary and sufficient to regulate the expression of many nuclear genes encoding chloroplastic proteins associated with photosynthesis...
  12. ncbi Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy
    Hiroto Inoue
    Department of Neurosurgery, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, Japan
    J Neurooncol 83:223-31. 2007
    ..This finding implies that ALA-PDT is a promising therapy for the treatment of apoptosis-reluctant tumors such as malignant gliomas...
  13. ncbi Anticancer effect of photodynamic therapy with hexenyl ester of 5-aminolevulinic acid in oral squamous cell carcinoma
    Yeon Hee Moon
    Department of Pathology, School of Dentistry, Chosun University, Gwangju 501 759, Korea
    Head Neck 32:1136-42. 2010
    ..In this study, the effect of photodynamic therapy (PDT) with hexenyl ester of ALA (ALA-hx) was examined in a human oral squamous cell carcinoma, YD10B cells...
  14. ncbi Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937
    Takashi Amo
    Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cell Biochem Funct 27:503-15. 2009
    ..These results indicated that ALA-based-PDA induced apoptotic cell death through a mitochondrial pathway and that ferrochelatase inhibitors might enhanced the effect of PDT for tumors even at low concentrations of ALA...
  15. ncbi The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes micro-oxo bishaem formation from monomeric iron(III) protoporphyrin IX
    J W Smalley
    The University of Liverpool, Oral Microbiology Group, Department of Clinical Dental Sciences, The Edwards Building, Daulby Street, Liverpool L69 3GN, UK
    Microbiology 152:1839-45. 2006
    ..It is concluded that the Arg- and Lys-gingipains with HA2 haemagglutinin domains may play a crucial role in haem-pigment formation by converting Fe(III)PPIX.OH monomers into [Fe(III)PPIX]2O and promoting their aggregation...
  16. ncbi Tetrapyrrole profiling in Arabidopsis seedlings reveals that retrograde plastid nuclear signaling is not due to Mg-protoporphyrin IX accumulation
    Michael Moulin
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 105:15178-83. 2008
    ..Instead, it is possible that a perturbation of tetrapyrrole synthesis may lead to localized ROS production or an altered redox state of the plastid, which could mediate retrograde signaling...
  17. ncbi Identification of a plastid response element that acts as an enhancer within the Chlamydomonas HSP70A promoter
    Erika D von Gromoff
    , Lehrstuhl Biochemie der Pflanzen, , Schaenzlestrasse 1 D-79104, Freiburg, Germany
    Nucleic Acids Res 34:4767-79. 2006
    ..This cis-acting sequence element is employed for induction of HSP70A by both MgProto and light, lending support to the model that light induction of this gene is mediated via MgProto...
  18. ncbi Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway
    Rafal Olszanecki
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 292:F148-57. 2007
    ..These findings underscore the prominent role of HO-1 in counteracting apoptosis in this 2K1C renovascular hypertension model...
  19. ncbi The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria
    Johan W Jonker
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 99:15649-54. 2002
    ....
  20. ncbi Cloning and expression of the tobacco CHLM sequence encoding Mg protoporphyrin IX methyltransferase and its interaction with Mg chelatase
    Ali Alawady
    , Pflanzenphysiologie, , Philippstr.13, Haus 12, 10115 Berlin, Deutschland
    Plant Mol Biol 57:679-91. 2005
    ..Implications for posttranslational regulation of MgPMT are discussed for the enzymatic steps at the beginning of the Mg branch...
  21. ncbi Accumulation of protoporphyrin-IX in rat Leydig cells following induction by 5-aminolevulinic acid and tramadol
    Maria Wołuń Cholewa
    Department of Biology and Cell Biology, University of Medical Sciences, Poznan, Poland doskon2amp edu pl
    Photomed Laser Surg 25:526-9. 2007
    ..This study aimed to monitor the accumulation of endogenous protoporphyrin-IX (PpIX) in rat Leydig cells (R(2)C) under the effect of 5-aminolevulinic acid (ALA) and various concentrations of tramadol, an analgesic drug...
  22. ncbi Mg-protoporphyrin IX and heme control HEMA, the gene encoding the first specific step of tetrapyrrole biosynthesis, in Chlamydomonas reinhardtii
    Zinaida Vasileuskaya
    University of Freiburg, Institute of Biology III, Schaenzlestrasse 1, D-79104 Freiburg, Germany
    Eukaryot Cell 4:1620-8. 2005
    ..Since MgProto is synthesized exclusively in plastids and heme is synthesized in plastids and mitochondria, the data suggest a role of these compounds as organellar signals that control expression of the nuclear HEMA gene...
  23. ncbi GUN4, a regulator of chlorophyll synthesis and intracellular signaling
    Robert M Larkin
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 299:902-6. 2003
    ..GUN4 binds the product and substrate of Mg- chelatase, an enzyme that produces Mg-Proto, and activates Mg-chelatase. Thus, GUN4 participates in plastid-to-nucleus signaling by regulating Mg-Proto synthesis or trafficking...
  24. ncbi A reporter system for the individual detection of hydrogen peroxide and singlet oxygen: its use for the assay of reactive oxygen species produced in vivo
    Ning Shao
    Faculty of Biology, Institute of Biology III, University of Freiburg, Schaenzlestrasse 1, D 79104 Freiburg, Germany
    Plant J 50:475-87. 2007
    ..This system thus makes it possible to test whether, under varying environmental conditions including the application of abiotic stress, hydrogen peroxide or singlet oxygen or both are produced...
  25. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    ..Our findings have implications for the survival of stem cells and tumor cells in hypoxic environments...
  26. ncbi Identification of a mammalian mitochondrial porphyrin transporter
    Partha C Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    Nature 443:586-9. 2006
    ..This process is blocked when the Abcb6 gene is silenced. Our results challenge previous assumptions about the intracellular movement of porphyrins and the factors controlling haem biosynthesis...
  27. ncbi Tobacco Mg protoporphyrin IX methyltransferase is involved in inverse activation of Mg porphyrin and protoheme synthesis
    Ali E Alawady
    , , Philippstr.13, Haus 12, 10115 Berlin, Germany
    Plant J 41:282-90. 2005
    ..It is proposed that reduced and increased MgPMT activity in chloroplasts is communicated to the cytoplasm for modulating transcriptional activities of regulatory enzymes of the pathway...
  28. ncbi Erythropoietic protoporphyria--report of a family and clinical review
    S Ozasa
    Department of Dermatology, Hiroshima University School of Medicine, Kasumi 1 2 3, Hiroshima, Japan
    J Dermatol 4:85-9. 1977
    ..The microscopic findings from skin biopsy specimens of the lesions resembled changes of the lipoid proteinosis...
  29. ncbi Knock-out of the magnesium protoporphyrin IX methyltransferase gene in Arabidopsis. Effects on chloroplast development and on chloroplast-to-nucleus signaling
    Dominique Pontier
    Laboratoire Génome et Développement des Plantes, CNRS Institut Recherche et Développement Universitéde Perpignan, F 66000 Perpignan, France
    J Biol Chem 282:2297-304. 2007
    ..This result suggests that the CHLH subunit might play an important regulatory role when the chlorophyll biosynthetic pathway is disrupted at this particular step...
  30. ncbi Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner
    Joanna Zawacka-Pankau
    Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk, Kladki 24, 80 822 Poland
    J Biol Chem 282:2466-72. 2007
    ..PDT treatment (2 J/cm2) of HCT116 cells induced p53-dependent activation of pro-apoptotic gene expression followed by growth suppression and induction of apoptosis...
  31. ncbi Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes
    Saadet Turkseven
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 289:H701-7. 2005
    ..These observations in experimental diabetes suggest that the vascular cytoprotective mechanism of HO-1 against oxidative stress requires an increase in EC-SOD and catalase...
  32. ncbi Lack of association of delta-aminolevulinic acid dehydratase genotype with cytogenetic damage in lead workers
    Fang Yang Wu
    Institute of Environmental Health, China Medical University, 91 Hsueh Shin Road, Taichung, Taiwan
    Int Arch Occup Environ Health 77:395-400. 2004
    ....
  33. ncbi Xantha-l encodes a membrane subunit of the aerobic Mg-protoporphyrin IX monomethyl ester cyclase involved in chlorophyll biosynthesis
    Kamila Rzeznicka
    Department of Biochemistry, Lund University, Box 124, SE-22100 Lund, Sweden
    Proc Natl Acad Sci U S A 102:5886-91. 2005
    ..The evidence suggests that the aerobic cyclase requires at least one soluble and two membrane-bound components...
  34. ncbi The use of digitized endoscopic imaging of 5-ALA-induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo
    Wei Zheng
    Division of Medical Sciences, National Cancer Centre, Singapore
    Int J Cancer 110:295-300. 2004
    ..0001, unpaired 2-sided Student's t-test), and thus has a potential to significantly improve the noninvasive diagnosis and evaluation of early oral neoplasia in vivo...
  35. ncbi The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters
    Hee Seon Kim
    Department of Food Science and Nutrition, Soonchunhyang University, Asan, Choongnam 336 745, Republic of Korea
    Environ Health Perspect 112:538-41. 2004
    ..In order to promote health and to minimize the toxicity of lead exposure more effectively, the nutritional management of iron in Korean workers should take both their ALAD genotypes and occupational lead exposures into account...
  36. ncbi Photodynamic effect of protoporphyrin diarginate (PPArg2) on methicillin-resistant Staphylococcus aureus and human dermal fibroblasts
    Mariusz Grinholc
    Department of Biotechnology, Division of Molecular Diagnostics, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
    Acta Biochim Pol 55:85-90. 2008
    ..aureus or fibroblasts when not irradiated. These results suggest that the protoporphyrin diarginate exerts a high bactericidal effect against methicillin-resistant S. aureus strain without harming eukaryotic cells...
  37. ncbi Heme, a plastid-derived regulator of nuclear gene expression in Chlamydomonas
    Erika D von Gromoff
    Fakultat fur Biologie, Institut fur Biologie III, Universitat Freiburg, D 79104 Freiburg, Germany
    Plant Cell 20:552-67. 2008
    ..We propose that Mg-protoporphyrin IX and heme may serve as plastid signals that regulate the expression of nuclear genes...
  38. ncbi Characterization of Chlamydomonas mutants defective in the H subunit of Mg-chelatase
    E Chekounova
    , , , 79104 Freiburg, Germany
    Mol Genet Genomics 266:363-73. 2001
    ....
  39. ncbi Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice
    Dominika Nowis
    Department of Immunology, Center of Biostructure Research, The Medical University of Warsaw, Banacha 1a, 02 097 Warsaw, Poland
    BMC Cancer 8:197. 2008
    ..In this study we decided to evaluate potential cytostatic/cytotoxic effects of zinc protoporphyrin IX (Zn(II)PPIX), a selective HO-1 inhibitor and to evaluate its antitumor activity in combination with chemotherapeutics...
  40. ncbi Toward understanding the high PDT efficacy of chlorin e6-polyvinylpyrrolidone formulations: photophysical and molecular aspects of photosensitizer-polymer interaction in vitro
    H A Isakau
    Scientific Pharmaceutical Center, RUE Belmedpreparaty, Fabritsius Street 30, 220007 Minsk, Belarus
    J Photochem Photobiol B 92:165-74. 2008
    ..Possible scenarios of how the presence of PVP can favorably affect the PDT efficacy of chlorin e6 in Ce6-PVP formulations are discussed...
  41. ncbi Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
    Tzong Shyuan Lee
    Graduate Institute of Life Sciences, National Defense Medical Center, and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    Nat Med 8:240-6. 2002
    ..The identification of HO-1 as a downstream effector of IL-10 provides new possibilities for improved therapeutic approaches for treating inflammatory diseases...
  42. ncbi Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy
    Patricia S P Thong
    Division of Medical Sciences, National Cancer Centre, Singapore
    J Environ Pathol Toxicol Oncol 27:35-42. 2008
    ..Specifically, lower fluence rate PDT appears to activate the body's immune response against untreated lesions...
  43. ncbi Characterization of three homologs of the large subunit of the magnesium chelatase from Chlorobaculum tepidum and interaction with the magnesium protoporphyrin IX methyltransferase
    Ethan T Johnson
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St Paul, Minnesota 55108, USA
    J Biol Chem 283:27776-84. 2008
    ..Our results conflict with expectations generated by previous gene inactivation studies and suggest a complex regulation of chlorophyll biosynthesis in green bacteria...
  44. ncbi Relationship between delta-aminolevulinic acid dehydratase genotypes and heme precursors in lead workers
    T Sakai
    Center of Occupational Medicine, Tokyo Rosai Hospital, Tokyo, Japan
    Am J Ind Med 38:355-60. 2000
    ..The objective of this study was to investigate the relationships between genotypes of delta-aminolevulinic acid (ALA) dehydratase (ALAD) and disturbances in the heme biosynthetic pathway by lead exposure...
  45. ncbi HO-1 induction attenuates renal damage and oxidative stress induced by K2Cr2O7
    Diana Barrera
    Department of Biology, School of Chemistry, , Ciudad Universitaria, 04510 Mexico City, Mexico
    Free Radic Biol Med 34:1390-8. 2003
    ..Our data suggest that HO-1 overexpression induced by SnCl(2) is responsible for the attenuation of renal damage and oxidative stress induced by K(2)Cr(2)O(7)...
  46. ncbi The steady-state level of Mg-protoporphyrin IX is not a determinant of plastid-to-nucleus signaling in Arabidopsis
    Nobuyoshi Mochizuki
    Department of Botany, Graduate School of Science, Kyoto University, Kitashirakawa, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 105:15184-9. 2008
    ..Taking these results together, we propose that the current model on plastid signaling must be revised...
  47. ncbi Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    Ming Li
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Diabetes 57:1526-35. 2008
    ....
  48. ncbi Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX
    B B Noodt
    Department of Pathology, Institute for Cancer Research, Montebello, Oslo, Norway
    Br J Cancer 74:22-9. 1996
    ....
  49. ncbi In situ conversion of coproporphyrinogen to heme by murine mitochondria: terminal steps of the heme biosynthetic pathway
    K L Proulx
    Department of Microbiology, University of Georgia, Athens 30602 2605
    Protein Sci 2:1092-8. 1993
    ..abstract truncated at 250 words)..
  50. ncbi Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    Dong Hyun Kim
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 325:833-40. 2008
    ..These findings highlight the pivotal role and symbiotic relationship of HO-1 and adiponectin in the modulation of the metabolic syndrome phenotype...
  51. ncbi Kinetics of 5-aminolevulinic acid-induced fluorescence in organ cultures of bronchial epithelium and tumor
    Fernando Gamarra
    Department of Pneumology, Medizinische Klinik Innenstadt, Ludwig Maximilians University of Munich, Germany
    Respiration 69:445-50. 2002
    ..CONCLUSION: Data obtained in this coculture system of bronchial epithelium and tumor is valuable to optimize modalities of fluorescence bronchoscopy for the diagnosis of early bronchial carcinoma...
  52. ncbi Heme oxygenase-1-dependent and -independent regulation of angiogenic genes expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human microvascular endothelial cells
    A Loboda
    Department of Medical Biotechnology, Faculty of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland
    Cell Mol Biol (Noisy-le-grand) 51:347-55. 2005
    ..Our data show that although both CoCl2 and CoPPIX induce HO-1, the influence of CoCl2 on VEGF does not involve HO-1 and is HIF-1-dependent, while the effect of CoPPIX does not involve HIF-1 but relies on HO-1...
  53. ncbi Amitrole treatment of etiolated barley seedlings leads to deregulation of tetrapyrrole synthesis and to reduced expression of Lhc and RbcS genes
    N La Rocca
    Dipartimento di Biologia, , Italy
    Planta 213:101-8. 2001
    ....
  54. ncbi Unique effects of zinc protoporphyrin on HO-1 induction and apoptosis
    G Yang
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 USA
    Blood 97:1306-13. 2001
    ..Lastly, increased apoptosis and nuclear localization were only seen with ZnPP, suggesting that increased ZnPP in disease states may serve as a cellular signaling mechanism...
  55. ncbi Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice
    Kaeko Hirai
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Japan
    Int J Cancer 120:500-5. 2007
    ..0003). In contrast, CoPPIX treatment increased HO-1 expression, enhanced tumorigenicity and MVD and reduced apoptosis. From these findings, inhibition of HO-1 by ZnPPIX provides relevant antitumoral effects...
  56. ncbi Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats
    B H Pannen
    Department of Anesthesiology and Critical Care Medicine, University of Freiburg, D 79106 Freiburg, Germany
    J Clin Invest 102:1220-8. 1998
    ..in contrast to CO, inducible NO synthase-derived NO is of only minor importance for the intrinsic control of hepatic perfusion and function under these conditions...
  57. ncbi Apoptosis induced in vivo by photodynamic therapy in normal brain and intracranial tumour tissue
    L Lilge
    Photonics Research Ontario, Department of Medical Biophysics and, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9
    Br J Cancer 83:1110-7. 2000
    ..These results suggest that at this time point, a minimal and fairly localized apoptotic effect is produced in brain tissues, the extent of which depends largely on the particular photosensitizer...
  58. ncbi Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX
    Johan W Jonker
    Div of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Am J Physiol Cell Physiol 292:C2204-12. 2007
    ..This mechanism may allow cells to prevent or reduce cytotoxicity of PPIX under excess conditions, without spillage under physiological conditions where PPIX is needed...
  59. ncbi Structural and biochemical characterization of Gun4 suggests a mechanism for its role in chlorophyll biosynthesis
    Paul A Davison
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Biochemistry 44:7603-12. 2005
    ..This mechanism could allow Gun4 to mediate magnesium protoporphyrin levels both for chlorophyll biosynthesis and for signaling to the nucleus...
  60. ncbi Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth
    K Doi
    Department of Microbiology, Kumamoto University School of Medicine, Japan
    Br J Cancer 80:1945-54. 1999
    ..In conclusion, HO-1 expression in the solid tumour may confer resistance of tumour cells to hypoxic stress as well as to NO-mediated cytotoxicity...
  61. ncbi Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway
    Masamichi Katori
    Division of Liver and Pancreas Transplantation, Dumot-UCLA Transplant Center, Los Angeles, California 90095, USA
    Transplantation 73:287-92. 2002
    ..This effect depends, at least in part, on HO-1-mediated up-regulation of a host antiapoptotic mechanism, especially in the early postreperfusion period...
  62. ncbi Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation
    Arun K Iyer
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    J Drug Target 15:496-506. 2007
    ....
  63. ncbi Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation
    Christopher J Mingone
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Lung Cell Mol Physiol 291:L337-44. 2006
    ..Thus control of endogenous formation of protoporphyrin IX from ALA by the availability of iron is potentially a novel physiological mechanism of controlling vascular function through regulating the activity of sGC...
  64. ncbi A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acid-photodynamic therapy in patients with psoriasis
    T Smits
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Rene Descartesdreef 1, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 155:429-36. 2006
    ..In these studies different treatment parameters were used, there was a variable clinical response, and a nonhomogeneous fluorescence was seen after irradiation with Wood's light...
  65. ncbi Glycoside esters of 5-aminolevulinic acid for photodynamic therapy of cancer
    Ramakrishnan Vallinayagam
    Institute of Chemistry, Neuchâtel University, avenue de Bellevaux, P O Box 2, CH 2007 Neuchatel, Switzerland
    Bioconjug Chem 19:821-39. 2008
    ..These results suggest the involvement of active non-glycoside-specific membrane transporter(s) for uptake and of esterases rather than glycosidases in the release of ALA from the glycoside esters of ALA...
  66. ncbi Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy
    Yi Ping Fang
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int J Pharm 356:144-52. 2008
    ....
  67. ncbi Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells
    A K Sinha
    Department of Dermatology, Wellman Center for Photomedicine, Harvard Medical School, Boston, MA 02114, USA
    Br J Cancer 95:485-95. 2006
    ..Our data suggest that MTX, when used to modulate intracellular production of endogenous PpIX, may provide a new combination PDT approach for certain cancers...
  68. ncbi Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma
    Andrew Pye
    Cornwall Dermatology Research, Peninsula Medical School, Knowledge Spa, Royal Cornwall Hospital, Treliske, Truro, Cornwall, TR1 3HD, UK
    J Cancer Res Clin Oncol 134:841-9. 2008
    ..This paper investigates this method of enhancement both in vitro and for the first time clinically for the treatment of nodular basal cell carcinoma (BCC)...
  69. ncbi Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single-blinded study
    S R Wiegell
    Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, Copenhagen NV, Denmark
    Br J Dermatol 158:740-6. 2008
    ..Daylight-PDT would make the treatment independent of the clinic and less painful due to the continuous activation of small amounts of porphyrins during its formation...
  70. ncbi Influence of administration methods on the accumulation of ALA-induced Pp-IX in mouse tongue tumors
    T Ogasawara
    Division of Dentistry and Oral Surgery, Department of Sensory and Locomotor Medicine, School of Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka, Fukui, Japan
    Oral Dis 12:415-9. 2006
    ..This study investigates the optimal method of administrating ALA by analyzing PpIX fluorescence in tongue tumor tissue...
  71. ncbi Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: A randomized controlled trial
    Merete Haedersdal
    Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    J Am Acad Dermatol 58:387-94. 2008
    ..Long-pulsed dye laser (LPDL)-assisted photodynamic therapy has been suggested to be superior to laser alone for acne vulgaris but no evidence is available...
  72. ncbi Subcellular localization pattern of protoporphyrin IX is an important determinant for its photodynamic efficiency of human carcinoma and normal cell lines
    Zhenyu Ji
    Department of Pathology, The National Hospital-Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 84:213-20. 2006
    ..Our finding suggests that future new photosensitizers with mitochondrially localizing properties may be designed for effective PDT...
  73. ncbi Fluorescence staining of human ovarian cancer tissue following application of 5-aminolevulinic acid: fluorescence microscopy studies
    Martin C Löning
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Lasers Surg Med 38:549-54. 2006
    ..Additionally, the selectivity of PP IX uptake is essential for a potential photodynamic therapy (PDT) of ovarian cancer metastases...
  74. ncbi 5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy
    Ludovic Bourre
    National Medical Laser Centre, Division of Surgical and Interventional Sciences, Royal Free and University College Medical School, University College London, United Kingdom
    Mol Cancer Ther 7:1720-9. 2008
    ..The derivatives are comparable in efficacy with 5-aminolaevulinic hexyl ester but less toxic and more stable at physiologic pH...
  75. ncbi Biochemical manipulation via iron chelation to enhance porphyrin production from porphyrin precursors
    Alison Curnow
    Cornwall Dermatology Research, Peninsula Medical School, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall, UK
    J Environ Pathol Toxicol Oncol 26:89-103. 2007
    ..Clinical investigation of this is currently underway...
  76. ncbi Protoporphyrin IX fluorescence photobleaching is a useful tool to predict the response of rat ovarian cancer following hexaminolevulinate photodynamic therapy
    Manuel Ascencio
    Department of Gynecology and Obstetrics, Lille University Hospital, Lille, France
    Lasers Surg Med 40:332-41. 2008
    ..This study aimed to assess the reliability of in vivo protoporphyrin IX (PpIX) fluorescence photobleaching as a predictive tool of the hexaminolevulinate PDT (HAL-PDT) response in a rat model of advanced ovarian cancer...
  77. ncbi Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas
    William J Cottrell
    Department of Imaging Sciences, University of Rochester, Rochester, New York, USA
    Clin Cancer Res 14:4475-83. 2008
    ..High irradiance and/or photosensitizer levels cause inefficient treatment from oxygen depletion in preclinical models...
  78. ncbi 5-Aminolevulinic acid-induced protoporphyrin-IX accumulation and associated phototoxicity in macrophages and oral cancer cell lines
    Sulbha Sharma
    Laser Biomedical Applications and Instrumentation Division, Raja Ramanna Center for Advanced Technology, R and D BLOCK D, Indore 452 013, India
    J Photochem Photobiol B 88:156-62. 2007
    ..Since macrophages are responsible for production and secretion of various tumor growth mediators, the effect of selective macrophage killing on the outcome of PDT would be significant...
  79. ncbi Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach
    Laurent Vaucher
    Institute of Physiology, University of Lausanne, Lausanne, Switzerland
    Lasers Surg Med 39:67-75. 2007
    ..The aim was to determine the threshold conditions for the cell survival...
  80. ncbi Aminolevulinic acid and photodynamic combination therapy in the treatment of actinic keratoses: caring for the patient
    Sharon E Harvie
    Faculty of Nursing Science, University of Montreal, Montreal, Canada
    Dermatol Nurs 19:31-4, 39. 2007
    ..The biologic mechanism involved with 5-aminolevulinic acid and photodynamic therapy, as well as the patient care recommended prior to and throughout the therapy, are outlined...
  81. ncbi Macromolecular delivery of 5-aminolaevulinic acid for photodynamic therapy using dendrimer conjugates
    Sinan Battah
    National Medical Laser Centre, University College London, Charles Bell House, 67 73 Riding House Street, London W1W 7EJ, United Kingdom
    Mol Cancer Ther 6:876-85. 2007
    ..In conclusion, macromolecular dendritic derivatives are capable of delivering 5-ALA efficiently to cells for sustained porphyrin synthesis...
  82. ncbi Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX
    Tobias J Beck
    Laser Research Laboratory, Ludwig Maximilians University, Marchioninistr 23, 81377 Munich, Germany
    Lasers Surg Med 39:386-93. 2007
    ....
  83. ncbi Parasiticidal effect of delta-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis is indirect and mediated through the killing of the host cells
    Oleg E Akilov
    Department of Dermatology, Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Exp Dermatol 16:651-60. 2007
    ..The clinical outcome observed with ALA-PDT is likely the result of unspecific tissue destruction accompanied by depopulation of macrophages rather than direct killing of parasites...
  84. ncbi 5-aminolevulinic acid-mediated photodynamic therapy on Hep-2 and MCF-7c3 cells
    Maria Gabriela Alvarez
    Departamento de Biologia Molecular, Facultad de Ciencias Exactas Físico Químicas y Naturales, UNRC, Universidad de Buenos Aires, Argentina
    J Environ Pathol Toxicol Oncol 26:75-82. 2007
    ..Different mechanisms of cell death were observed in both cell lines, depending on the different intracellular localization of PPIX...
  85. ncbi Analysis of differential PDT effect in rat bladder tumor models according to concentrations of intravesical hexyl-aminolevulinate
    Saoussen Berrahmoune
    Photobiology in Cancerology, Centre Alexis Vautrin, CRAN Nancy University, CNRS, Avenue de Bourgogne 54511, and Department of Pathology and Cytology, University Hospital Nancy, Vandoeuvre les Nancy Cedex, France
    Photochem Photobiol Sci 7:1018-24. 2008
    ..Mitochondria were shown to be the critical photodamaged sites of HAL/PpIX PDT and as such tissue sensitivity to treatment can be estimated through investigation of intracellular PpIX distribution...
  86. ncbi Heterogeneity of fluorescence in psoriasis after application of 5-aminolaevulinic acid: an immunohistochemical study
    M M Kleinpenning
    Department of Dermatology, Radboud University Nijmegen Medical Center, Rene Descartesdreef 1, 6525 GL Nijmegen, The Netherlands
    Br J Dermatol 155:539-45. 2006
    ..Variations in fluorescence might explain the variable and the mostly partial clinical response of psoriasis seen after photodynamic therapy (PDT)...
  87. ncbi Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line 320DM
    Susan Shahzidi
    Department of Pathology, Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, 0310 Oslo, Norway
    J Environ Pathol Toxicol Oncol 25:159-71. 2006
    ....
  88. ncbi Regulation of porphyrin synthesis and photodynamic therapy in heavy metal intoxication
    Borislava Grinblat
    Faculty of Life Science, Bar Ilan University, Ramat Gan 52900 Israel
    J Environ Pathol Toxicol Oncol 25:145-58. 2006
    ..The efficacy of ALA-PDT was reduced in correlation with decreased activities of the enzymes during lead intoxication. We may conclude that lead poisoning adversely affects the outcome of ALA photodynamic therapy of cancer...
  89. ncbi Evaluation of dipeptide-derivatives of 5-aminolevulinic acid as precursors for photosensitizers in photodynamic therapy
    Yann Berger
    Institute of Chemistry, , avenue de Bellevaux, PO Box 2, CH-2007, , Switzerland
    Bioorg Med Chem 11:1343-51. 2003
    ..Thus drugs coupled to Gly-Gly-/Gly-Pro-derivatives may selectively target defined cells in human cancer, depending on specific cellular activating pathways expressed by the cells...
  90. ncbi The effect of photodynamic therapy on rat urinary bladder with orthotopic urothelial carcinoma
    S Gronlund-Pakkanen
    Department of Surgery, Kuopio University Hospital, Kuopio, Finland
    BJU Int 92:125-30. 2003
    ....
  91. ncbi PDT effects of m-THPC and ALA, phototoxicity and apoptosis
    L Bourre
    Département Laser, Hopital Laennec, 44093 Nantes, France
    Apoptosis 7:221-30. 2002
    ..01) for both the PROb and B16 cells. These results indicate that the apoptosis rate in PDT cell killing varies considerably according to cell type and sensitizer...
  92. ncbi Potential efficacy of a delta 5-aminolevulinic acid thermosetting gel formulation for use in photodynamic therapy of lesions of the gastrointestinal tract
    Ludovic Bourre
    , Neurochirurgie, CHU Nantes, 44480 Nantes, France
    Pharmacol Res 45:159-65. 2002
    ....
  93. ncbi Comparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer
    A Marti
    Department of Urology, University Hospital, Lausanne, Switzerland
    J Urol 170:428-32. 2003
    ..This approach allows us to optimize PpIX tissue distribution for photodynamic therapy in superficial bladder cancer...
  94. ncbi Photodynamic effects induced by aminolevulinic acid esters on human cervical carcinoma cells in culture
    W Xiang
    Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany
    Photochem Photobiol 74:617-23. 2001
    ..The results indicate that improved or at least comparable photodynamic effects can be achieved by using remarkably lower doses of ALA esters...
  95. ncbi Photodynamic inhibition of enzymatic detachment of human cancer cells from a substratum
    Anatoly Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochim Biophys Acta 1670:1-11. 2004
    ..Photodynamic inhibition of enzymatic cell detachment may be related to PDT-induced inhibition of tumour metastasis...
  96. ncbi 5-aminolevulinic acid-based photodynamic therapy in leukemia cell HL60
    Su Juan Zhang
    Institute of Biomedical Engineering, School of Life Science and Technology, Xi an Jiaotong University, Xi an, China
    Photochem Photobiol 79:545-50. 2004
    ..Therefore a hypothetical idea can be brought forward that ALA-based PDT can be used for inactivation of leukemia cell HL60 and these optimal parameters may be useful for clinical application...
  97. ncbi [5-Aminolevulinic acid (ALA) and its applications in neurosurgery]
    Paweł Grieb
    Zakład Farmakologii Doświadczalnej, Instytut Medycyny Doświadczalnej i Klinicznej PAN im M Mossakowskiego, ul Pawinskiego 5, 02 106 Warszawa
    Neurol Neurochir Pol 38:201-7. 2004
    ..Ongoing research concentrates also on the use of ALA for a selective elimination of glioma cells in situ, and on lipophilic ALA derivatives with more favorable pharmacokinetic properties...
  98. ncbi In vitro/in vivo correlations between transdermal delivery of 5-aminolaevulinic acid and cutaneous protoporphyrin IX accumulation and effect of formulation
    J C Tsai
    Institute of Clinical Pharmacy and Department of Dermatology, College of Medicine, National Cheng Kung University, 1 University Rd, Tainan 70101, Taiwan
    Br J Dermatol 146:853-62. 2002
    ..Although different formulations containing variable amounts of ALA have been applied in PDT, the dose-response relationships between transdermal ALA delivery and cutaneous protoporphyrin IX (PpIX) accumulation have not been studied...
  99. ncbi Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo
    R G Tunstall
    Centre for Photobiology and Photodynamic Therapy, University of Leeds, Leeds LS2 9JT, UK
    Br J Cancer 87:246-50. 2002
    ....
  100. ncbi Transfer of protoporphyrin IX between cells
    Johan Moan
    Department of Biophysics, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol 76:526-9. 2002
    ..Light exposure slightly increased the rate of loss of PpIX from WiDr cells...
  101. ncbi Metabolic characterization of tumor cell-specific protoporphyrin IX accumulation after exposure to 5-aminolevulinic acid in human colonic cells
    Rene C Krieg
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Photochem Photobiol 76:518-25. 2002
    ....

Research Grants121 found, 100 shown here

  1. STRUCTURE/FUNCTION AND REACTION MECHANISM OF PGHS
    Ah Lim Tsai; Fiscal Year: 2002
    ..Characterize the mechanistic differences between the Fe-PGHS and PGHS reconstituted with Mn(II) or Mn(III) protoporphyrins. 2) Elucidate the mechanism of self-inactivation occurring in both the peroxidase and cyclooxygenase ..
  2. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2009
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  3. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  4. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..Defining intestinal heme uptake pathways will have a great impact in understanding disorders associated with iron overload (hereditary hemochromatosis, iron overload secondary to blood transfusions) and nutritional iron deficiency ..
  5. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  6. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra Juul; Fiscal Year: 2009
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  7. NUTRITIONAL & METABOLIC REGULATION OF BODY WEIGHT
    RICHARD GALBRAITH; Fiscal Year: 2003
    ..abstract_text> ..
  8. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  9. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2010
    ..This information will have significant implications in the pathophysiology and therapeutic potentials of the IAS dysfunction. ..
  10. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra E Juul; Fiscal Year: 2010
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  11. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra Juul; Fiscal Year: 2009
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  12. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra Juul; Fiscal Year: 2007
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  13. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2007
    ..abstract_text> ..
  14. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2007
    ..This information will have significant implications in the pathophysiology and therapeutic potentials of the IAS dysfunction. ..
  15. Micro CT/NIR Molecular Imaging of Cancer
    Brian Pogue; Fiscal Year: 2007
    ....
  16. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2005
    ..Information produced by these studies will permit an understanding of the pathophysiology that underlies disorders of the LAS, and provide a rationale for development of therapies to treat disorders of the IAS. ..
  17. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  18. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2001
    ..The proposed studies should provide important information leading to a better understanding of the pathophysiology and the treatment of anorectal disorders. ..
  19. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPINCHTER
    Satish Rattan; Fiscal Year: 1992
    ..The proposed studies should provide important information on the physiology and pharmacology of the IAS which may be useful in the understanding of pathophysiology, the effects of various drugs and the treatment of anorectal disorders...
  20. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 1993
    ..It is envisaged that the proposed studies provide important information on the physiology and pharmacology of the IAS leading to a better understanding of the pathophysiology and in turn the treatment, of anorectal disorders...
  21. Brain and Behavior in Early Iron Deficiency
    Betsy Lozoff; Fiscal Year: 2007
    ..Collectively, the program will make a major contribution in understanding, treating, and preventing brain and behavior effects of iron deficiency, the world's most common single nutrient disorder. ..
  22. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2007
    ..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. ..
  23. Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts
    Betsy Lozoff; Fiscal Year: 2009
    ....
  24. DIGE Package: Variable Mode Imager and Spot Picker
    Jeffrey Friedman; Fiscal Year: 2007
    ....
  25. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2004
    ....
  26. The Renal Medulla and Hypertension
    David Stec; Fiscal Year: 2009
    ..A better understanding of the how the kidney controls blood pressure may provide an opportunity to develop new drugs to treat people with hypertension who are resistant to current therapies. ..
  27. Mechanisms of In Vivo Ethanol-Induced Mitochondrial Depolarization
    Zhi Zhong; Fiscal Year: 2010
    ....
  28. Type 2 Diabetes Risk in Women With Gestational Diabetes
    Catherine Kim; Fiscal Year: 2007
    ..These projects address the growing incidence of GDM, which is increasing due to advancing maternal age and obesity, as well as the increasing rates of DM, a major public health problem. ..
  29. The Renal Medulla and Hypertension
    David E Stec; Fiscal Year: 2010
    ..A better understanding of the how the kidney controls blood pressure may provide an opportunity to develop new drugs to treat people with hypertension who are resistant to current therapies. ..
  30. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ....
  31. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2010
    ..The SHIP study will provide insight into the pathophysiology of glucose intolerance, and the findings will have implications not only for diabetes prevention but also for other diseases that focus on sex hormones as mediators. ..
  32. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ....
  33. Improving Survival For Small-For-Size Liver Grafts
    Zhi Zhong; Fiscal Year: 2004
    ..This work will develop mechanism-based strategies to increase the use and improve the outcome of partial livers for transplantation in the clinic. ..
  34. PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURY
    DIPAK DAS; Fiscal Year: 2009
    ....
  35. PHOSPHOLIPID DEGRADATION IN REPERFUSION INJURY
    DIPAK DAS; Fiscal Year: 1993
    ..This will eventually be applicable to patient care for reduction of myocardial injury during ischemia and reperfusion...
  36. MYOCARDIAL PRESERVATION DURING ISCHEMIC ARREST
    DIPAK DAS; Fiscal Year: 2009
    ..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
  37. Neuromaturational Delays in Iron Deficient Anemic Infants
    Betsy Lozoff; Fiscal Year: 2009
    ..Long-term ill effects continuing into adolescence, despite iron therapy in infancy, could therefore have major public health implications. ..
  38. NEUROMATURATION DELAYS IN IRON DEFICIENT ANEMIC INFANTS
    Betsy Lozoff; Fiscal Year: 2000
    ..s. ..
  39. Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts
    Betsy Lozoff; Fiscal Year: 2009
    ....
  40. PHOSPHOLIPIDS IN MYOCARDIAL REPERFUSION INJURY
    DIPAK DAS; Fiscal Year: 2000
    ..The ultimate goal of this investigation is to develop modalities to block apoptosis during reperfusion of the ischemic heart, which will hopefully ameliorate reperfusion injury. ..
  41. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2002
    ..The results of these studies will demonstrate the molecular mechanisms of constitutive cellular protection against myocardial ischemia/ reperfusion injury by examining the redox signaling process. ..