protoporphyrins

Summary

Summary: Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.

Top Publications

  1. pmc Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells
    Cy Hyun Kim
    National Research and Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Int J Nanomedicine 6:1357-63. 2011
  2. doi Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    Ming Li
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Diabetes 57:1526-35. 2008
  3. doi Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cell
    Chung Wook Chung
    Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Eur J Pharm Biopharm 80:453-8. 2012
  4. doi Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma
    Yanhong Lv
    Department of Anatomy, Harbin Medical University, Harbin, P R China
    Cell Physiol Biochem 30:321-33. 2012
  5. pmc Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact
    Sylvie Létoffé
    Unité des Membranes Bactériennes, Departement de Microbiologie, Institut Pasteur, CNRS URA 2172, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 106:11719-24. 2009
  6. ncbi Zinc protoporphyrin: A metabolite with a mission
    R F Labbe
    Department of Laboratory Medicine, Box 359743, University of Washington, Seattle, WA 98104, USA
    Clin Chem 45:2060-72. 1999
  7. ncbi Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    FASEB J 20:2651-3. 2006
  8. ncbi Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes
    Saadet Turkseven
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 289:H701-7. 2005
  9. ncbi Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX
    Alicja Jozkowicz
    Department of Vascular Surgery, University of Vienna, Austria
    Antioxid Redox Signal 5:155-62. 2003
  10. doi Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells
    Tetsuya Ogino
    Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata, Okayama 700 8558, Japan
    Mol Cell Biochem 358:297-307. 2011

Detail Information

Publications233 found, 100 shown here

  1. pmc Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells
    Cy Hyun Kim
    National Research and Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Int J Nanomedicine 6:1357-63. 2011
    ..Furthermore, an increased amount of PpIX in HuCC-T1 cells induced increased production of ROS by irradiation, resulting in increased phototoxicity...
  2. doi Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    Ming Li
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Diabetes 57:1526-35. 2008
    ....
  3. doi Effect of surfactant on 5-aminolevulinic acid uptake and PpIX generation in human cholangiocarcinoma cell
    Chung Wook Chung
    Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
    Eur J Pharm Biopharm 80:453-8. 2012
    ..Cotreatment with the surfactant resulted in an increased intracellular ALA level, PpIX formation, and phototoxicity...
  4. doi Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma
    Yanhong Lv
    Department of Anatomy, Harbin Medical University, Harbin, P R China
    Cell Physiol Biochem 30:321-33. 2012
    ..The process initially damaged mitochondria, activated pro-apoptotic factors Bax and cytochrome c and suppressed the anti-apoptotic factor Bcl-2, activated caspase-3 to executed apoptosis through mitochondrial signaling pathway...
  5. pmc Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact
    Sylvie Létoffé
    Unité des Membranes Bactériennes, Departement de Microbiologie, Institut Pasteur, CNRS URA 2172, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 106:11719-24. 2009
    ..YfeX and EfeB are widespread and highly conserved in bacteria. We propose that their physiological function is to retrieve iron from heme...
  6. ncbi Zinc protoporphyrin: A metabolite with a mission
    R F Labbe
    Department of Laboratory Medicine, Box 359743, University of Washington, Seattle, WA 98104, USA
    Clin Chem 45:2060-72. 1999
    ..Biochemical research techniques, both in vivo and in vitro, are described for further studies into the role of ZnPP in metabolism and physiology...
  7. ncbi Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    FASEB J 20:2651-3. 2006
    ..Because CoPP, unlike heme, is neither a prooxidant nor a substrate for HO-1, it might be considered as a potential therapeutic agent in situations where up-regulation of HO-1 is desired...
  8. ncbi Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes
    Saadet Turkseven
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 289:H701-7. 2005
    ..These observations in experimental diabetes suggest that the vascular cytoprotective mechanism of HO-1 against oxidative stress requires an increase in EC-SOD and catalase...
  9. ncbi Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX
    Alicja Jozkowicz
    Department of Vascular Surgery, University of Vienna, Austria
    Antioxid Redox Signal 5:155-62. 2003
    ..Thus, HO activity up-regulates VEGF production and augments the capability of endothelial cells to respond to exogenous stimulation...
  10. doi Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells
    Tetsuya Ogino
    Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata, Okayama 700 8558, Japan
    Mol Cell Biochem 358:297-307. 2011
    ..Inhibition of ABCG2 transporter system could be a new target for the improvement of photodynamic therapy...
  11. doi Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937
    Takashi Amo
    Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cell Biochem Funct 27:503-15. 2009
    ..These results indicated that ALA-based-PDA induced apoptotic cell death through a mitochondrial pathway and that ferrochelatase inhibitors might enhanced the effect of PDT for tumors even at low concentrations of ALA...
  12. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    ..Our findings have implications for the survival of stem cells and tumor cells in hypoxic environments...
  13. doi 5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institutuion
    M Hefti
    Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
    Swiss Med Wkly 138:180-5. 2008
    ..We report on the feasibility of the method in daily clinical practice, the benefits for patients and surgeons, the technical limitations and the methods we have devised of overcoming these limitations...
  14. doi Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture
    Masatoshi Ohnishi
    Department of Pharmacotherapeutics, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Gakuencho 1, Fukuyama, Hiroshima 729 0292, Japan
    Brain Res 1347:170-8. 2010
    ..Thrombin-induced cortical injury may be also regulated by the expression of HO-1 and the resultant production of heme degradation products such as carbon monoxide...
  15. ncbi 5-Aminolevulinic acid-induced protoporphyrin-IX accumulation and associated phototoxicity in macrophages and oral cancer cell lines
    Sulbha Sharma
    Laser Biomedical Applications and Instrumentation Division, Raja Ramanna Center for Advanced Technology, R and D BLOCK D, Indore 452 013, India
    J Photochem Photobiol B 88:156-62. 2007
    ..Since macrophages are responsible for production and secretion of various tumor growth mediators, the effect of selective macrophage killing on the outcome of PDT would be significant...
  16. doi Detection and photodynamic therapy of inflamed atherosclerotic plaques in the carotid artery of rabbits
    Chenghai Peng
    Department of Cardiology, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, PR China
    J Photochem Photobiol B 102:26-31. 2011
    ..ALA mediated PDT could reduce macrophage content and inhibit plaque progression, indicating a promising approach to treat inflamed atherosclerotic plaques...
  17. ncbi The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria
    Tamara Azarashvili
    Institut fur Neurobiochemie, Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Cell Calcium 42:27-39. 2007
    ..This study provides evidence for PBR involvement in PTP opening, controlling the Ca2+-induced Ca2+ efflux, and AIF release from mitochondria, important stages of initiation of programmed cell death...
  18. doi Apoptosis induced by sonodynamic treatment by protoporphyrin IX on MDA-MB-231 cells
    Yixiang Li
    Key Laboratory of Ministry of Education for Medicinal Plant Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, China
    Ultrasonics 52:490-6. 2012
    ..These findings primarily indicate a Caspase-depended apoptosis could be induced by PpIX-SDT in MDA-MB-231 cells, and the intracellular ROS was involved during the apoptotic process...
  19. doi The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1
    Stefanie Grimm
    Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Strasse 24, Jena, Germany
    Biofactors 37:17-24. 2011
    ..However, further studies are necessary to investigate more antioxidants and other substances, which might affect the outcome of photodynamic treatment in cancer therapy...
  20. pmc Zinc protoporphyrin IX binds heme crystals to inhibit the process of crystallization in Plasmodium falciparum
    Jayasree K Iyer
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Department of International Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Mol Med 9:175-82. 2003
    ..In endemic malaria areas, severe iron deficiency anemia should be treated with antimalarials along with iron replenishment...
  21. doi Heme oxygenase-1 prevents hyperthyroidism induced hepatic damage via an antioxidant and antiapoptotic pathway
    Murat Giris
    Department of Biochemistry, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
    J Surg Res 164:266-75. 2010
    ..We aimed to investigate the pathogenesis of liver dysfunction caused by hyperthyroidism through inducing heme oxygenase-1 (HO-1) expression, which has antioxidant and anti-apoptotic properties...
  22. doi Fisetin induces Nrf2-mediated HO-1 expression through PKC-δ and p38 in human umbilical vein endothelial cells
    Seung Eun Lee
    Department of Microbiology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
    J Cell Biochem 112:2352-60. 2011
    ..In summary, these findings suggest that induction of HO-1 expression via Nrf2 activation may contribute to the cytoprotection exerted by fisetin against H(2)O(2) -induced oxidative stress in HUVECs...
  23. pmc Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma
    D Ickowicz Schwartz
    Faculty of Life Science, Bar Ilan University, Ramat Gan 52900, Israel
    Br J Cancer 90:1833-41. 2004
    ..We suggest that efficient photodynamic therapy of cancer facilitated by ALA administration can be enhanced using combined therapeutic modalities...
  24. pmc Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats
    Fei Wang
    Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
    World J Gastroenterol 15:3009-14. 2009
    ..To investigate the effect of heme oxygenase-1 (HO-1) expression on immune liver fibrosis induced by cobalt protoporphyrin (CoPP) in rats...
  25. ncbi Prolonged allogeneic islet graft survival by protoporphyrins
    Antonello Pileggi
    Cell Transplant Center, Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10th Avenue R 134, Miami, FL 33136, USA
    Cell Transplant 14:85-96. 2005
    ..We tested the effect of the use of protoporphyrins (CoPP and FePP), powerful inducers of the cytoprotective protein heme-oxygenase 1 (HO-1), on allogeneic islet ..
  26. ncbi Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway
    Masamichi Katori
    Division of Liver and Pancreas Transplantation, Dumot UCLA Transplant Center, Los Angeles, California 90095, USA
    Transplantation 73:287-92. 2002
    ..We report on the cytoprotective effects of HO-1 in a rat cardiac I/R injury model, using cobalt protoporphyrin (CoPP) as HO-1 inducer and zinc protoporphyrin (ZnPP) as HO-1 inhibitor...
  27. ncbi Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
    Tzong Shyuan Lee
    Graduate Institute of Life Sciences, National Defense Medical Center, and Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    Nat Med 8:240-6. 2002
    ..The identification of HO-1 as a downstream effector of IL-10 provides new possibilities for improved therapeutic approaches for treating inflammatory diseases...
  28. pmc Identification of a plastid response element that acts as an enhancer within the Chlamydomonas HSP70A promoter
    Erika D von Gromoff
    Institut fur Biologie III, Lehrstuhl Biochemie der Pflanzen, Universitat Freiburg, Schaenzlestrasse 1 D 79104, Freiburg, Germany
    Nucleic Acids Res 34:4767-79. 2006
    ..This cis-acting sequence element is employed for induction of HSP70A by both MgProto and light, lending support to the model that light induction of this gene is mediated via MgProto...
  29. ncbi Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries
    D A Tulis
    Department of Medicine, Baylor College of Medicine, 6550 Fannin, SM MS 1423, Houston, TX 77030, USA
    Atherosclerosis 155:113-22. 2001
    ..These results directly implicate HO-1 and the products of heme catabolism in attenuating the arterial response to injury and ensuing vascular wall remodeling...
  30. ncbi Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface
    Andre Sollwedel
    Reproductive Immunology Group, Institute of Medical Immunology, Biomedizinisches Forschungszentrum BMFZ, Charité Medical University of Berlin, Germany
    J Immunol 175:4875-85. 2005
    ..e., Bag-1, and by activating T regulatory cells rather than by changing the local cytokine profile...
  31. pmc Laparoscopic fluorescence diagnosis for intraabdominal fluorescence targeting of peritoneal carcinosis experimental studies
    Johannes Gahlen
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 235:252-60. 2002
    ..To assess 5-aminolevulinic acid (ALA)-induced protoporphyrin IX accumulation and fluorescence in peritoneal colon carcinoma metastases and its benefits for laparoscopic fluorescence diagnosis...
  32. doi Anticancer effect of photodynamic therapy with hexenyl ester of 5-aminolevulinic acid in oral squamous cell carcinoma
    Yeon Hee Moon
    Department of Pathology, School of Dentistry, Chosun University, Gwangju 501 759, Korea
    Head Neck 32:1136-42. 2010
    ..In this study, the effect of photodynamic therapy (PDT) with hexenyl ester of ALA (ALA-hx) was examined in a human oral squamous cell carcinoma, YD10B cells...
  33. doi ALA and its clinical impact, from bench to bedside
    Barbara Krammer
    University of Salzburg, Department of Molecular Biology, Austria
    Photochem Photobiol Sci 7:283-9. 2008
    ..Pharmacokinetical studies have demonstrated a low systemic photosensitivity and excretion of PpIX via natural routes...
  34. ncbi Kinetics and subcellular localization of 5-ALA-induced PpIX in DHL cells via two-photon excitation fluorescence microscopy
    Rong Chen
    Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou, Fujian 350007, PR China
    Int J Oncol 32:861-7. 2008
    ..Two-photon excitation fluorescence microscope is a useful tool for studying 5-ALA-induced PpIX subcellular localization...
  35. ncbi Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer
    Wolfgang Kemmner
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Str 10, 13125 Berlin, Germany
    FASEB J 22:500-9. 2008
    ..Furthermore, accumulation of intracellular PpIX because of FECH siRNA silencing provides a small-molecule-based approach to molecular imaging and molecular therapy...
  36. ncbi Subcellular localization pattern of protoporphyrin IX is an important determinant for its photodynamic efficiency of human carcinoma and normal cell lines
    Zhenyu Ji
    Department of Pathology, The National Hospital Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 84:213-20. 2006
    ..Our finding suggests that future new photosensitizers with mitochondrially localizing properties may be designed for effective PDT...
  37. doi Fluorescence detection and depletion of T47D breast cancer cells from human mononuclear cell-enriched blood preparations by photodynamic treatment: Basic in vitro experiments towards the removal of circulating tumor cells
    Verena G Ziegler
    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
    Lasers Surg Med 43:548-56. 2011
    ..This study aims at providing basic evidence towards fluorescence detection and photodynamic depletion of scattered cancer cells from blood preparations...
  38. doi Intraclutch variation in avian eggshell pigmentation: the anaemia hypothesis
    Greet De Coster
    Department of Biology, Terrestrial Ecology Unit, Ghent University, Ghent, Belgium
    Oecologia 170:297-304. 2012
    ..However, the overall increase in pigment darkness along the laying sequence suggests that pigments also accumulate by enhanced red blood cell production caused by anaemia due to egg production itself...
  39. ncbi Study of cell killing effect on S180 by ultrasound activating protoporphyrin IX
    Xiao Bing Wang
    College of Life Sciences, Shaanxi Normal University, Xi an 710062, China
    Ultrasonics 48:135-40. 2008
    ..This biological mechanism might be involved in mediating the effects on S180 cells and resulting in the cell damage seen with SDT...
  40. doi In vivo uptake of a haem analogue Zn protoporphyrin IX by the human malaria parasite P. falciparum-infected red blood cells
    Robson Sartorello
    Departamento de Fisiologia, Instituto de Biocincias, Universidade de So Paulo, 05508900 São Paulo, SP, Brazil
    Cell Biol Int 34:859-65. 2010
    ....
  41. pmc A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase
    Carrie Hiser
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, United States
    Biochemistry 52:1385-96. 2013
    ..The high affinity and specificity of a number of compounds for this region, and its conservation and impact on CcO activity, support its physiological significance...
  42. doi Improved peptide prodrugs of 5-ALA for PDT: rationalization of cellular accumulation and protoporphyrin IX production by direct determination of cellular prodrug uptake and prodrug metabolization
    Francesca Giuntini
    Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U K
    J Med Chem 52:4026-37. 2009
    ..In agreement with PpIX fluorescence studies, at a concentration of 0.1 mM, l-Phe derivatives 4m and 4o, and l-Leu, l-Met, and l-Glu derivatives 4f, 4k, and 4u, exhibit significantly enhanced photoxicity in PAM212 cells compared to ALA...
  43. ncbi Endoscopic fluorescence detection of intraepithelial neoplasia in Barrett's esophagus after oral administration of aminolevulinic acid
    T Stepinac
    Institute of Environmental Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland
    Endoscopy 35:663-8. 2003
    ..This study evaluates endoscopic fluorescence detection in patients having Barrett's esophagus and compares the results to those of standard endoscopy with random four-quadrant biopsies...
  44. doi The centrality of PBGD expression levels on ALA-PDT efficacy
    Avital Schauder
    Microscopy Unit, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, 52900, Israel
    Photochem Photobiol Sci 10:1310-7. 2011
    ..This enables efficient ALA-PDT, even when PBGD is not fully active. Conversely, ALAD loss resulted in reduced PpIX synthesis and consequently failure in ALA-PDT, due to the absence of compensation mechanism for ALAD...
  45. pmc A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery
    P A Valdes
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 37:1817-9. 2012
    ..The simplicity of the method lends itself to the enticing prospect that the method could be applicable to wide-field applications in quantitative fluorescence imaging and dosimetry in photodynamic therapy...
  46. ncbi Protoporphyrin IX binding and transport by recombinant mouse PBR
    Gregor Wendler
    Division of Hormone Research, Departments of Cell Biology, Pharmacology and Neurosciences, Georgetown University School of Medicine, 3900 Reservoir Road, NW, Washington, DC, USA
    Biochem Biophys Res Commun 311:847-52. 2003
    ..These results suggest that PBR, in addition to its role in cholesterol and coproporphyrinogen III transport, is also directing the mitochondrial PPIX import, a function that can be ascribed to the 18kDa PBR protein alone...
  47. ncbi The weight loss elicited by cobalt protoporphyrin is related to decreased activity of nitric oxide synthase in the hypothalamus
    Muyao Li
    Department of Medicine, University of Vermont, C209 Given Bldg, 89 Beaumont Ave, Burlington, Vermont 05405, USA
    J Appl Physiol (1985) 100:1983-91. 2006
    ..We also demonstrate that CoPP decreases NOS activity but that it paradoxically increases neuronal NOS transcript expression and increases neuronal NOS protein content on Western blotting...
  48. doi Targeting of p53 and its homolog p73 by protoporphyrin IX
    Alicja Sznarkowska
    Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
    FEBS Lett 585:255-60. 2011
    ..We propose that PpIX disrupts the p53/MDM2 or MDMX and p73/MDM2 complexes and thereby activates the p53- or p73-dependent cancer cell death...
  49. doi Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity
    Markus Biburger
    Nikolaus Fiebiger Center for Molecular Medicine, Medical Department III, University Hospital of Erlangen, Germany
    J Leukoc Biol 87:193-202. 2010
    ..In summary, these data suggest that HO-1 expression by T(regs) might contribute to their typical reluctance to proliferate but does not account independently for their suppressive functions...
  50. doi Quinolone compounds enhance delta-aminolevulinic acid-induced accumulation of protoporphyrin IX and photosensitivity of tumour cells
    Yoshiko Ohgari
    Department of Biotechnology, Kyoto Institute of Technology, Kyoto, Japan
    J Biochem 149:153-60. 2011
    ..Hence, we now propose that the use of quinolones in combination with ALA may be an extremely effective approach for the treatment modalities for PDT of various tumour tissues in clinical practice...
  51. ncbi Relation between intracellular location and photodynamic efficacy of 5-aminolevulinic acid-induced protoporphyrin IX in vitro. Comparison between human glioblastoma cells and other cancer cell lines
    Reinhard Sailer
    Institut fur Lasertechnologien in der Medizin und Messtechnik an der Universitat Ulm, Helmholtzstr 12, 89081, Ulm, Germany
    Photochem Photobiol Sci 6:145-51. 2007
    ....
  52. doi Comparison of pharmacokinetics, intracellular localizations and sonodynamic efficacy of endogenous and exogenous protoporphyrin IX in sarcoma 180 cells
    Xiaobing Wang
    Key Laboratory of Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Shaanxi, Xi an, China
    Ultrasonics 50:803-10. 2010
    ....
  53. doi Induction of sonodynamic effect with protoporphyrin IX on isolate hepatoma-22 cells
    Na Mi
    College of Life Sciences, Shaanxi Normal University, 199 Chang An South Road, Xi an, Shaanxi, China
    Ultrasound Med Biol 35:680-6. 2009
    ..16% in SDT-treated group). These results indicated that the ultrasonically-induced cell killing effect could be enhanced by PpIX, and that the mitochondrial pathway might be involved in the cell damage process...
  54. doi The anti-inflammatory role of heme oxygenase-1 in lipopolysaccharide and cytokine-stimulated inducible nitric oxide synthase and nitric oxide production in human periodontal ligament cells
    Young Suk Kim
    Department of Oral and Maxillofacial Pathology, College of Dentistry, Wonkwang University, Iksan, South Korea
    J Periodontol 80:2045-55. 2009
    ....
  55. pmc Zinc protoporphyrin regulates cyclin D1 expression independent of heme oxygenase inhibition
    Ping La
    Division of Neonatology, Children s Hospital of Philadelphia, PA 19104, USA
    J Biol Chem 284:36302-11. 2009
    ..These observations show HO independent effects of ZnPP on cyclin D1 expression and tumorigenesis...
  56. pmc Fluorescence distribution and photodynamic effect of ALA-induced PP IX in the DMH rat colonic tumour model
    J Bedwell
    Department of Surgery, University College London, UK
    Br J Cancer 65:818-24. 1992
    ..There is also a greater concentration difference between the PP IX levels in tumours and in normal mucosa and normal muscle than with the other photosensitisers raising the possibility of more selective necrosis in tumours...
  57. ncbi Amitrole treatment of etiolated barley seedlings leads to deregulation of tetrapyrrole synthesis and to reduced expression of Lhc and RbcS genes
    N La Rocca
    Dipartimento di Biologia, , Italy
    Planta 213:101-8. 2001
    ....
  58. pmc Comparison of delta-aminolaevulinic acid and its methyl ester as an inducer of porphyrin synthesis in cultured cells
    R Washbrook
    Department of Molecular Pathology, UCL Medical School, London, UK
    Br J Cancer 75:1417-20. 1997
    ..6% in ALA-treated cells with a corresponding reduction in cell-associated PPIX (P < 0.05). A variable initial elevation in haem levels in ALA-ME-treated cells was observed, but did not reach statistically significant levels...
  59. pmc Tetrapyrrole profiling in Arabidopsis seedlings reveals that retrograde plastid nuclear signaling is not due to Mg-protoporphyrin IX accumulation
    Michael Moulin
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 105:15178-83. 2008
    ..Instead, it is possible that a perturbation of tetrapyrrole synthesis may lead to localized ROS production or an altered redox state of the plastid, which could mediate retrograde signaling...
  60. ncbi Chloroplast to nucleus communication triggered by accumulation of Mg-protoporphyrinIX
    Asa Strand
    Plant Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Nature 421:79-83. 2003
    ..Accumulation of Mg-ProtoIX is both necessary and sufficient to regulate the expression of many nuclear genes encoding chloroplastic proteins associated with photosynthesis...
  61. ncbi Expression of haem oxygenase in cirrhotic rat liver
    Chang Li Wei
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore, 119260
    J Pathol 199:324-34. 2003
    ..Induction of HO-1 may be mediated partially by iNOS. However, once it is induced, HO-1 may be important in modulating iNOS activity, thus playing a protective role in liver cirrhosis...
  62. ncbi Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy
    Hiroto Inoue
    Department of Neurosurgery, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, Japan
    J Neurooncol 83:223-31. 2007
    ..This finding implies that ALA-PDT is a promising therapy for the treatment of apoptosis-reluctant tumors such as malignant gliomas...
  63. ncbi Pharmacological preconditioning with doxorubicin. Implications of heme oxygenase-1 induction in doxorubicin-induced hepatic injury in rats
    K Ito
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, 101-0062, Tokyo, Japan
    Biochem Pharmacol 62:1249-55. 2001
    ..These results strongly suggest that pharmacological preconditioning with DOX may generally help to attenuate subsequent oxidant-induced hepatic injury...
  64. pmc A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin
    John W Smalley
    Unit of Basic Dental Science, Department of Clinical Dental Sciences, University of Liverpool, The Edwards Building, Daulby Street, Liverpool L69 3GN, UK
    Biochem J 379:833-40. 2004
    ..These results show that one or both of RgpA and RgpB gingipains, in addition to the lysine-specific gingipain, is necessary for the production of mu-oxo bishaem from haemoglobin by whole cells of P. gingivalis...
  65. ncbi The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes micro-oxo bishaem formation from monomeric iron(III) protoporphyrin IX
    J W Smalley
    The University of Liverpool, Oral Microbiology Group, Department of Clinical Dental Sciences, The Edwards Building, Daulby Street, Liverpool L69 3GN, UK
    Microbiology 152:1839-45. 2006
    ..It is concluded that the Arg- and Lys-gingipains with HA2 haemagglutinin domains may play a crucial role in haem-pigment formation by converting Fe(III)PPIX.OH monomers into [Fe(III)PPIX]2O and promoting their aggregation...
  66. pmc The heme oxygenase/carbon monoxide system is involved in the auxin-induced cucumber adventitious rooting process
    Wei Xuan
    College of Life Sciences, Cooperative Demonstration Laboratory of Centrifuge Technique, Nanjing Agricultural University, Nanjing, China
    Plant Physiol 148:881-93. 2008
    ....
  67. pmc Knock-out of the magnesium protoporphyrin IX methyltransferase gene in Arabidopsis. Effects on chloroplast development and on chloroplast-to-nucleus signaling
    Dominique Pontier
    Laboratoire Génome et Développement des Plantes, CNRS Institut Recherche et Développement Universitéde Perpignan, F 66000 Perpignan, France
    J Biol Chem 282:2297-304. 2007
    ..This result suggests that the CHLH subunit might play an important regulatory role when the chlorophyll biosynthetic pathway is disrupted at this particular step...
  68. doi Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    Dong Hyun Kim
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 325:833-40. 2008
    ..These findings highlight the pivotal role and symbiotic relationship of HO-1 and adiponectin in the modulation of the metabolic syndrome phenotype...
  69. ncbi Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1
    Stefan G Tullius
    Department of General and Transplantation Surgery, Charite Campus Virchow Clinic, D 13353 Berlin, Germany
    Transplantation 74:591-8. 2002
    ....
  70. pmc Porphyrin homeostasis maintained by ABCG2 regulates self-renewal of embryonic stem cells
    Jimmy Susanto
    Genomics Research Center, Academia Sinica, Taipei, Taiwan, Republic of China
    PLoS ONE 3:e4023. 2008
    ..The ATP binding cassette transporter ABCG2 is expressed in a wide variety of somatic and embryonic stem cells. However, whether it plays an important role in stem cell maintenance remains to be defined...
  71. ncbi The CHLI1 subunit of Arabidopsis thaliana magnesium chelatase is a target protein of the chloroplast thioredoxin
    Akinori Ikegami
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Yokohama 226 8501, Japan
    J Biol Chem 282:19282-91. 2007
    ..Our findings strongly suggest that chlorophyll biosynthesis is subject to chloroplast biogenesis regulation networks to coordinate them with the photosynthetic pathways in chloroplasts...
  72. ncbi Inhibition of heme oxygenase-1 increases responsiveness of melanoma cells to ALA-based photodynamic therapy
    Jürgen Frank
    zet Life Science Laboratory Linz, 4020, Linz, Austria
    Int J Oncol 31:1539-45. 2007
    ....
  73. ncbi Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX
    Johan W Jonker
    Div of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Am J Physiol Cell Physiol 292:C2204-12. 2007
    ..This mechanism may allow cells to prevent or reduce cytotoxicity of PPIX under excess conditions, without spillage under physiological conditions where PPIX is needed...
  74. ncbi Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway
    Rafal Olszanecki
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 292:F148-57. 2007
    ..These findings underscore the prominent role of HO-1 in counteracting apoptosis in this 2K1C renovascular hypertension model...
  75. pmc Mg-protoporphyrin IX and heme control HEMA, the gene encoding the first specific step of tetrapyrrole biosynthesis, in Chlamydomonas reinhardtii
    Zinaida Vasileuskaya
    University of Freiburg, Institute of Biology III, Schaenzlestrasse 1, D 79104 Freiburg, Germany
    Eukaryot Cell 4:1620-8. 2005
    ..Since MgProto is synthesized exclusively in plastids and heme is synthesized in plastids and mitochondria, the data suggest a role of these compounds as organellar signals that control expression of the nuclear HEMA gene...
  76. ncbi A reporter system for the individual detection of hydrogen peroxide and singlet oxygen: its use for the assay of reactive oxygen species produced in vivo
    Ning Shao
    Faculty of Biology, Institute of Biology III, University of Freiburg, Schaenzlestrasse 1, D 79104 Freiburg, Germany
    Plant J 50:475-87. 2007
    ..This system thus makes it possible to test whether, under varying environmental conditions including the application of abiotic stress, hydrogen peroxide or singlet oxygen or both are produced...
  77. pmc Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice
    Dominika Nowis
    Department of Immunology, Center of Biostructure Research, The Medical University of Warsaw, Banacha 1a, 02 097 Warsaw, Poland
    BMC Cancer 8:197. 2008
    ..In this study we decided to evaluate potential cytostatic/cytotoxic effects of zinc protoporphyrin IX (Zn(II)PPIX), a selective HO-1 inhibitor and to evaluate its antitumor activity in combination with chemotherapeutics...
  78. ncbi GUN4, a regulator of chlorophyll synthesis and intracellular signaling
    Robert M Larkin
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 299:902-6. 2003
    ..GUN4 binds the product and substrate of Mg- chelatase, an enzyme that produces Mg-Proto, and activates Mg-chelatase. Thus, GUN4 participates in plastid-to-nucleus signaling by regulating Mg-Proto synthesis or trafficking...
  79. ncbi Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy
    Patricia S P Thong
    Division of Medical Sciences, National Cancer Centre, Singapore
    J Environ Pathol Toxicol Oncol 27:35-42. 2008
    ..Specifically, lower fluence rate PDT appears to activate the body's immune response against untreated lesions...
  80. pmc Heme, a plastid-derived regulator of nuclear gene expression in Chlamydomonas
    Erika D von Gromoff
    Fakultat fur Biologie, Institut fur Biologie III, Universitat Freiburg, D 79104 Freiburg, Germany
    Plant Cell 20:552-67. 2008
    ..We propose that Mg-protoporphyrin IX and heme may serve as plastid signals that regulate the expression of nuclear genes...
  81. ncbi Kinetics of 5-aminolevulinic acid-induced fluorescence in organ cultures of bronchial epithelium and tumor
    Fernando Gamarra
    Department of Pneumology, Medizinische Klinik Innenstadt, Ludwig Maximilians University of Munich, Germany
    Respiration 69:445-50. 2002
    ..5-Aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PPIX) fluorescence improves the differentiation of tumor and normal tissue in the bladder, skin and brain...
  82. pmc The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria
    Johan W Jonker
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 99:15649-54. 2002
    ....
  83. ncbi Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner
    Joanna Zawacka-Pankau
    Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk, Kladki 24, 80 822 Poland
    J Biol Chem 282:2466-72. 2007
    ..PDT treatment (2 J/cm2) of HCT116 cells induced p53-dependent activation of pro-apoptotic gene expression followed by growth suppression and induction of apoptosis...
  84. ncbi Identification of a mammalian mitochondrial porphyrin transporter
    Partha C Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105 2794, USA
    Nature 443:586-9. 2006
    ..This process is blocked when the Abcb6 gene is silenced. Our results challenge previous assumptions about the intracellular movement of porphyrins and the factors controlling haem biosynthesis...
  85. ncbi Accumulation of protoporphyrin-IX in rat Leydig cells following induction by 5-aminolevulinic acid and tramadol
    Maria Wołuń-Cholewa
    Department of Biology and Cell Biology, University of Medical Sciences, Poznan, Poland doskon2amp edu pl
    Photomed Laser Surg 25:526-9. 2007
    ..This study aimed to monitor the accumulation of endogenous protoporphyrin-IX (PpIX) in rat Leydig cells (R(2)C) under the effect of 5-aminolevulinic acid (ALA) and various concentrations of tramadol, an analgesic drug...
  86. ncbi Photodynamic effect of protoporphyrin diarginate (PPArg2) on methicillin-resistant Staphylococcus aureus and human dermal fibroblasts
    Mariusz Grinholc
    Department of Biotechnology, Division of Molecular Diagnostics, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
    Acta Biochim Pol 55:85-90. 2008
    ..aureus or fibroblasts when not irradiated. These results suggest that the protoporphyrin diarginate exerts a high bactericidal effect against methicillin-resistant S. aureus strain without harming eukaryotic cells...
  87. pmc Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX
    B B Noodt
    Department of Pathology, Institute for Cancer Research, Montebello, Oslo, Norway
    Br J Cancer 74:22-9. 1996
    ....
  88. ncbi Characterization of Chlamydomonas mutants defective in the H subunit of Mg-chelatase
    E Chekounova
    , , , 79104 Freiburg, Germany
    Mol Genet Genomics 266:363-73. 2001
    ....
  89. pmc The protective effect of delta-aminolevulinic acid dehydratase 1-2 and 2-2 isozymes against blood lead with higher hematologic parameters
    Hee Seon Kim
    Department of Food Science and Nutrition, Soonchunhyang University, Asan, Choongnam 336 745, Republic of Korea
    Environ Health Perspect 112:538-41. 2004
    ..In order to promote health and to minimize the toxicity of lead exposure more effectively, the nutritional management of iron in Korean workers should take both their ALAD genotypes and occupational lead exposures into account...
  90. ncbi HO-1 induction attenuates renal damage and oxidative stress induced by K2Cr2O7
    Diana Barrera
    Department of Biology, School of Chemistry, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico City, Mexico
    Free Radic Biol Med 34:1390-8. 2003
    ..Our data suggest that HO-1 overexpression induced by SnCl(2) is responsible for the attenuation of renal damage and oxidative stress induced by K(2)Cr(2)O(7)...
  91. ncbi Cloning and expression of the tobacco CHLM sequence encoding Mg protoporphyrin IX methyltransferase and its interaction with Mg chelatase
    Ali Alawady
    Institut fur Biologie, Pflanzenphysiologie, Humboldt Universitat, Philippstr 13, Haus 12, 10115 Berlin, Deutschland
    Plant Mol Biol 57:679-91. 2005
    ..Implications for posttranslational regulation of MgPMT are discussed for the enzymatic steps at the beginning of the Mg branch...
  92. ncbi Lack of association of delta-aminolevulinic acid dehydratase genotype with cytogenetic damage in lead workers
    Fang Yang Wu
    Institute of Environmental Health, China Medical University, 91 Hsueh Shin Road, Taichung, Taiwan
    Int Arch Occup Environ Health 77:395-400. 2004
    ....
  93. ncbi The use of digitized endoscopic imaging of 5-ALA-induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo
    Wei Zheng
    Division of Medical Sciences, National Cancer Centre, Singapore
    Int J Cancer 110:295-300. 2004
    ..0001, unpaired 2-sided Student's t-test), and thus has a potential to significantly improve the noninvasive diagnosis and evaluation of early oral neoplasia in vivo...
  94. ncbi Erythropoietic protoporphyria--report of a family and clinical review
    S Ozasa
    Department of Dermatology, Hiroshima University School of Medicine, Kasumi 1 2 3, Hiroshima, Japan
    J Dermatol 4:85-9. 1977
    ..The microscopic findings from skin biopsy specimens of the lesions resembled changes of the lipoid proteinosis...
  95. pmc In situ conversion of coproporphyrinogen to heme by murine mitochondria: terminal steps of the heme biosynthetic pathway
    K L Proulx
    Department of Microbiology, University of Georgia, Athens 30602 2605
    Protein Sci 2:1092-8. 1993
    ..abstract truncated at 250 words)..
  96. ncbi Relationship between delta-aminolevulinic acid dehydratase genotypes and heme precursors in lead workers
    T Sakai
    Center of Occupational Medicine, Tokyo Rosai Hospital, Tokyo, Japan
    Am J Ind Med 38:355-60. 2000
    ..The objective of this study was to investigate the relationships between genotypes of delta-aminolevulinic acid (ALA) dehydratase (ALAD) and disturbances in the heme biosynthetic pathway by lead exposure...
  97. ncbi Tobacco Mg protoporphyrin IX methyltransferase is involved in inverse activation of Mg porphyrin and protoheme synthesis
    Ali E Alawady
    Institut für Biologie Pflanzenphysiologie, Humboldt Universitat zu Berlin, Philippstr 13, Haus 12, 10115 Berlin, Germany
    Plant J 41:282-90. 2005
    ..It is proposed that reduced and increased MgPMT activity in chloroplasts is communicated to the cytoplasm for modulating transcriptional activities of regulatory enzymes of the pathway...
  98. pmc The steady-state level of Mg-protoporphyrin IX is not a determinant of plastid-to-nucleus signaling in Arabidopsis
    Nobuyoshi Mochizuki
    Department of Botany, Graduate School of Science, Kyoto University, Kitashirakawa, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 105:15184-9. 2008
    ..Taking these results together, we propose that the current model on plastid signaling must be revised...
  99. doi Characterization of three homologs of the large subunit of the magnesium chelatase from Chlorobaculum tepidum and interaction with the magnesium protoporphyrin IX methyltransferase
    Ethan T Johnson
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St Paul, Minnesota 55108, USA
    J Biol Chem 283:27776-84. 2008
    ..Our results conflict with expectations generated by previous gene inactivation studies and suggest a complex regulation of chlorophyll biosynthesis in green bacteria...
  100. pmc Xantha-l encodes a membrane subunit of the aerobic Mg-protoporphyrin IX monomethyl ester cyclase involved in chlorophyll biosynthesis
    Kamila Rzeznicka
    Department of Biochemistry, Lund University, Box 124, SE 22100 Lund, Sweden
    Proc Natl Acad Sci U S A 102:5886-91. 2005
    ..The evidence suggests that the aerobic cyclase requires at least one soluble and two membrane-bound components...
  101. doi Toward understanding the high PDT efficacy of chlorin e6-polyvinylpyrrolidone formulations: photophysical and molecular aspects of photosensitizer-polymer interaction in vitro
    H A Isakau
    Scientific Pharmaceutical Center, RUE Belmedpreparaty, Fabritsius Street 30, 220007 Minsk, Belarus
    J Photochem Photobiol B 92:165-74. 2008
    ..Possible scenarios of how the presence of PVP can favorably affect the PDT efficacy of chlorin e6 in Ce6-PVP formulations are discussed...

Research Grants123 found, 100 shown here

  1. STRUCTURE/FUNCTION AND REACTION MECHANISM OF PGHS
    Ah Lim Tsai; Fiscal Year: 2002
    ..Characterize the mechanistic differences between the Fe-PGHS and PGHS reconstituted with Mn(II) or Mn(III) protoporphyrins. 2) Elucidate the mechanism of self-inactivation occurring in both the peroxidase and cyclooxygenase ..
  2. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2009
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  3. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  4. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..Defining intestinal heme uptake pathways will have a great impact in understanding disorders associated with iron overload (hereditary hemochromatosis, iron overload secondary to blood transfusions) and nutritional iron deficiency ..
  5. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  6. NUTRITIONAL & METABOLIC REGULATION OF BODY WEIGHT
    RICHARD GALBRAITH; Fiscal Year: 2003
    ..abstract_text> ..
  7. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2001
    ..The proposed studies should provide important information leading to a better understanding of the pathophysiology and the treatment of anorectal disorders. ..
  8. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra Juul; Fiscal Year: 2009
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  9. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  10. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2010
    ..This information will have significant implications in the pathophysiology and therapeutic potentials of the IAS dysfunction. ..
  11. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra E Juul; Fiscal Year: 2010
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  12. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra Juul; Fiscal Year: 2009
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  13. Optimizing Neuroprotection Following Perinatal Asphyxia
    Sandra Juul; Fiscal Year: 2007
    ..This work will produce important data with direct clinical application to perinatal asphyxia, and possibly to other mechanisms of brain injury in infants and children. ..
  14. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2007
    ..abstract_text> ..
  15. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2007
    ..This information will have significant implications in the pathophysiology and therapeutic potentials of the IAS dysfunction. ..
  16. Micro CT/NIR Molecular Imaging of Cancer
    Brian Pogue; Fiscal Year: 2007
    ....
  17. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2005
    ..Information produced by these studies will permit an understanding of the pathophysiology that underlies disorders of the LAS, and provide a rationale for development of therapies to treat disorders of the IAS. ..
  18. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  19. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPINCHTER
    Satish Rattan; Fiscal Year: 1992
    ..The proposed studies should provide important information on the physiology and pharmacology of the IAS which may be useful in the understanding of pathophysiology, the effects of various drugs and the treatment of anorectal disorders...
  20. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 1993
    ..It is envisaged that the proposed studies provide important information on the physiology and pharmacology of the IAS leading to a better understanding of the pathophysiology and in turn the treatment, of anorectal disorders...
  21. MODE OF ACTION OF THE PHOTO-ACTIVATED PORPHYRINS
    David Kessel; Fiscal Year: 1980
    ..g., study of transport phenomena, membrane protein cross-linking, cell-surface charge & hydrophobicity, and fluorescence signals form porphyrins in cell-free systems and within tumor cells...
  22. DIGE Package: Variable Mode Imager and Spot Picker
    Jeffrey Friedman; Fiscal Year: 2007
    ....
  23. Brain and Behavior in Early Iron Deficiency
    Betsy Lozoff; Fiscal Year: 2007
    ..Collectively, the program will make a major contribution in understanding, treating, and preventing brain and behavior effects of iron deficiency, the world's most common single nutrient disorder. ..
  24. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2007
    ..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. ..
  25. Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts
    Betsy Lozoff; Fiscal Year: 2009
    ....
  26. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2004
    ....
  27. The Renal Medulla and Hypertension
    David Stec; Fiscal Year: 2009
    ..A better understanding of the how the kidney controls blood pressure may provide an opportunity to develop new drugs to treat people with hypertension who are resistant to current therapies. ..
  28. The Renal Medulla and Hypertension
    David E Stec; Fiscal Year: 2010
    ..A better understanding of the how the kidney controls blood pressure may provide an opportunity to develop new drugs to treat people with hypertension who are resistant to current therapies. ..
  29. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2010
    ..The SHIP study will provide insight into the pathophysiology of glucose intolerance, and the findings will have implications not only for diabetes prevention but also for other diseases that focus on sex hormones as mediators. ..
  30. Mechanisms of In Vivo Ethanol-Induced Mitochondrial Depolarization
    Zhi Zhong; Fiscal Year: 2010
    ....
  31. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ....
  32. Type 2 Diabetes Risk in Women With Gestational Diabetes
    Catherine Kim; Fiscal Year: 2007
    ..These projects address the growing incidence of GDM, which is increasing due to advancing maternal age and obesity, as well as the increasing rates of DM, a major public health problem. ..
  33. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ....
  34. Improving Survival For Small-For-Size Liver Grafts
    Zhi Zhong; Fiscal Year: 2004
    ..This work will develop mechanism-based strategies to increase the use and improve the outcome of partial livers for transplantation in the clinic. ..
  35. PHOSPHOLIPID DEGRADATION IN REPERFUSION INJURY
    DIPAK DAS; Fiscal Year: 1993
    ..This will eventually be applicable to patient care for reduction of myocardial injury during ischemia and reperfusion...
  36. MYOCARDIAL PRESERVATION DURING ISCHEMIC ARREST
    DIPAK DAS; Fiscal Year: 2009
    ..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
  37. Neuromaturational Delays in Iron Deficient Anemic Infants
    Betsy Lozoff; Fiscal Year: 2009
    ..Long-term ill effects continuing into adolescence, despite iron therapy in infancy, could therefore have major public health implications. ..
  38. PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURY
    DIPAK DAS; Fiscal Year: 2009
    ....
  39. NEUROMATURATION DELAYS IN IRON DEFICIENT ANEMIC INFANTS
    Betsy Lozoff; Fiscal Year: 2000
    ..s. ..
  40. Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts
    Betsy Lozoff; Fiscal Year: 2009
    ....
  41. PHOSPHOLIPIDS IN MYOCARDIAL REPERFUSION INJURY
    DIPAK DAS; Fiscal Year: 2000
    ..The ultimate goal of this investigation is to develop modalities to block apoptosis during reperfusion of the ischemic heart, which will hopefully ameliorate reperfusion injury. ..
  42. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2002
    ..The results of these studies will demonstrate the molecular mechanisms of constitutive cellular protection against myocardial ischemia/ reperfusion injury by examining the redox signaling process. ..