Summary: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.

Top Publications

  1. ncbi Bacterial iron homeostasis
    Simon C Andrews
    School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    FEMS Microbiol Rev 27:215-37. 2003
  2. ncbi Pharmacological and clinical aspects of heme oxygenase
    Nader G Abraham
    New York Medical College, Basic Science Building, Valhalla, NY 10595, USA
    Pharmacol Rev 60:79-127. 2008
  3. ncbi Heme synthesis by plastid ferrochelatase I regulates nuclear gene expression in plants
    Jesse D Woodson
    Plant Biology Laboratory and Howard Hughes Medical Institute, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 21:897-903. 2011
  4. pmc Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization
    Aubrey J Cunnington
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Nat Med 18:120-7. 2012
  5. pmc Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
    Vitor R R Mendonça
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador, Bahia, Brazila
    Infect Immun 80:1445-54. 2012
  6. pmc Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
    Sen Lin
    Department of Neurology, Daping Hospital, Third Military Medical University, Yuzhong District, Chongqing, China
    J Neuroinflammation 9:46. 2012
  7. pmc Discovery and characterization of a unique mycobacterial heme acquisition system
    Michael V Tullius
    Departments of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:5051-6. 2011
  8. ncbi Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
    Ana Pamplona
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Nat Med 13:703-10. 2007
  9. ncbi Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential
    Ananta Paine
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Biochem Pharmacol 80:1895-903. 2010
  10. ncbi Adaptations against heme toxicity in blood-feeding arthropods
    Aurelio V Graca-Souza
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Av Brigadeiro Trompowsky, S N, Cidade Universitaria, Ilha do Fundao, 21941 690 Rio de Janeiro, RJ, Brazil
    Insect Biochem Mol Biol 36:322-35. 2006

Detail Information

Publications360 found, 100 shown here

  1. ncbi Bacterial iron homeostasis
    Simon C Andrews
    School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    FEMS Microbiol Rev 27:215-37. 2003
  2. ncbi Pharmacological and clinical aspects of heme oxygenase
    Nader G Abraham
    New York Medical College, Basic Science Building, Valhalla, NY 10595, USA
    Pharmacol Rev 60:79-127. 2008
    This review is intended to stimulate interest in the effect of increased expression of heme oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological states...
  3. ncbi Heme synthesis by plastid ferrochelatase I regulates nuclear gene expression in plants
    Jesse D Woodson
    Plant Biology Laboratory and Howard Hughes Medical Institute, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 21:897-903. 2011
    ..The gun6-1D mutant overexpresses the conserved plastid ferrochelatase 1 (FC1, heme synthase)...
  4. pmc Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization
    Aubrey J Cunnington
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Nat Med 18:120-7. 2012
    ..Induction of heme oxygenase-1 (HO-1) mediates tolerance to the cytotoxic effects of heme during malarial hemolysis but might impair ..
  5. pmc Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria
    Vitor R R Mendonça
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador, Bahia, Brazila
    Infect Immun 80:1445-54. 2012
    ..The oxidation of Hb by free radicals causes the release of heme, which amplifies inflammation...
  6. pmc Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
    Sen Lin
    Department of Neurology, Daping Hospital, Third Military Medical University, Yuzhong District, Chongqing, China
    J Neuroinflammation 9:46. 2012
    ..Toll-like receptor 4 (TLR4) plays a role in inflammatory damage caused by brain disorders...
  7. pmc Discovery and characterization of a unique mycobacterial heme acquisition system
    Michael V Tullius
    Departments of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:5051-6. 2011
    ..Here we demonstrate a newly characterized pathway, whereby M. tuberculosis can use free heme and heme from hemoglobin as an iron source...
  8. ncbi Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
    Ana Pamplona
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Nat Med 13:703-10. 2007
    Cerebral malaria claims more than 1 million lives per year. We report that heme oxygenase-1 (HO-1, encoded by Hmox1) prevents the development of experimental cerebral malaria (ECM)...
  9. ncbi Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential
    Ananta Paine
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Biochem Pharmacol 80:1895-903. 2010
    b>Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of heme degradation. Induction of HO-1 protects against the cytotoxicity of oxidative stress and apoptotic cell death...
  10. ncbi Adaptations against heme toxicity in blood-feeding arthropods
    Aurelio V Graca-Souza
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Av Brigadeiro Trompowsky, S N, Cidade Universitaria, Ilha do Fundao, 21941 690 Rio de Janeiro, RJ, Brazil
    Insect Biochem Mol Biol 36:322-35. 2006
    ..of vertebrate hemoglobin in the midgut of blood-feeding arthropods results in the production of large amounts of heme, a potentially cytotoxic molecule...
  11. pmc Prolonged neutrophil dysfunction after Plasmodium falciparum malaria is related to hemolysis and heme oxygenase-1 induction
    Aubrey J Cunnington
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    J Immunol 189:5336-46. 2012
    ..This acquired neutrophil dysfunction is a consequence of induction of the cytoprotective, heme-degrading enzyme heme oxygenase-1 (HO-1) in neutrophil progenitors in bone marrow...
  12. pmc Heme degradation and vascular injury
    John D Belcher
    Department of Medicine, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota 55455, USA
    Antioxid Redox Signal 12:233-48. 2010
    b>Heme is an essential molecule in aerobic organisms. Heme consists of protoporphyrin IX and a ferrous (Fe(2+)) iron atom, which has high affinity for oxygen (O(2))...
  13. ncbi Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 318:1786-9. 2007
    The circadian clock temporally coordinates metabolic homeostasis in mammals. Central to this is heme, an iron-containing porphyrin that serves as prosthetic group for enzymes involved in oxidative metabolism as well as transcription ..
  14. pmc Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway
    Sonya Cosgrove
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 286:7692-704. 2011
    ..of the protease-rich environment of the CF lung on human hemoglobin and to assess the proinflammatory effect of heme on CF bronchial epithelium...
  15. pmc Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
    Elsa Seixas
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Proc Natl Acad Sci U S A 106:15837-42. 2009
    ..Under inflammatory conditions, cell-free hemoglobin can be oxidized, releasing its heme prosthetic groups and producing deleterious free heme...
  16. pmc Molecular hijacking of siroheme for the synthesis of heme and d1 heme
    Shilpa Bali
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Proc Natl Acad Sci U S A 108:18260-5. 2011
    Modified tetrapyrroles such as chlorophyll, heme, siroheme, vitamin B(12), coenzyme F(430), and heme d(1) underpin a wide range of essential biological functions in all domains of life, and it is therefore surprising that the syntheses of ..
  17. ncbi Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection
    Martino L di Salvo
    Dipartimento di Scienze Biochimiche A Rossi Fanelli, Sapienza Universita di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy
    Med Hypotheses 80:633-6. 2013
    ..as the importance of glycine in cancer is concerned, a central role of this amino acid, namely its participation to heme biosynthesis, has been neglected...
  18. ncbi Heme oxygenase-1: unleashing the protective properties of heme
    Leo E Otterbein
    Division of Pulmonary and Critical Care Medicine, Montifiore University Hospital, University of Pittsburgh School of Medicine, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    Trends Immunol 24:449-55. 2003
    b>Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the induction of ferritin, an iron-binding protein)...
  19. pmc Heme utilization in Campylobacter jejuni
    Kristian A Ridley
    Department of Genetics, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, United Kingdom
    J Bacteriol 188:7862-75. 2006
    A putative iron- and Fur-regulated hemin uptake gene cluster, composed of the transport genes chuABCD and a putative heme oxygenase gene (Cj1613c), has been identified in Campylobacter jejuni NCTC 11168...
  20. pmc Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota
    Jose Henrique M Oliveira
    Laboratório de Bioquímica de Artrópodes Hematófagos, Instituto de Bioquimica Medica, Programa de Biologia Molecular e Biotecnologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
    PLoS Pathog 7:e1001320. 2011
    ..in the midgut of sugar-fed (SF) mosquitoes and a blood-meal immediately decreased ROS through a mechanism involving heme-mediated activation of PKC. This event occurred in parallel with an expansion of gut bacteria...
  21. ncbi The IL-12p70/IL-10 interplay is differentially regulated by free heme and hemozoin in murine bone-marrow-derived macrophages
    Mathieu Cambos
    Department of Biological Sciences, Universite du Quebec a Montreal, Montreal, Que, Canada
    Int J Parasitol 40:1003-12. 2010
    ..Although free heme contributes to malarial anemia by inducing oxidative damage of red blood cells (RBCs) and enhancing their clearance ..
  22. pmc Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy
    Stefan W Ryter
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 41:251-60. 2009
    b>Heme oxygenase-1 (HO-1), a ubiquitous inducible stress-response protein, serves a major metabolic function in heme turnover. HO activity cleaves heme to form biliverdin-IXalpha, carbon monoxide (CO), and iron...
  23. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    ..However, blocking heme biosynthesis reverses the hypoxic susceptibility of Bcrp(-/-) progenitor cells, a finding that indicates that heme ..
  24. ncbi Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue
    Jesse M Gray
    Howard Hughes Medical Institute and Department of Anatomy, The University of California, San Francisco, California 94143 0452, USA
    Nature 430:317-22. 2004
    ..elegans' preferred level, and require gcy-35 activity. Our results suggest that GCY-35 is regulated by molecular oxygen, and that social feeding can be a behavioural strategy for responding to hyperoxic environments...
  25. pmc Identification and characterization of the hemophore-dependent heme acquisition system of Yersinia pestis
    M S Rossi
    , 75724 Paris Cedex 15, France
    Infect Immun 69:6707-17. 2001
    Yersinia pestis possesses a heme-protein acquisition system (Hmu) that allows it to utilize heme and heme-protein complexes as the sole sources of iron. Analysis of the Y...
  26. pmc Control of intracellular heme levels: heme transporters and heme oxygenases
    Anwar A Khan
    Department of Medicine, Section of Hematology Oncology, University of Illinois College of Medicine, 909 South Wolcott Avenue, Chicago, IL 0612, USA
    Biochim Biophys Acta 1813:668-82. 2011
    b>Heme serves as a co-factor in proteins involved in fundamental biological processes including oxidative metabolism, oxygen storage and transport, signal transduction and drug metabolism...
  27. ncbi Identification of an intestinal heme transporter
    Majid Shayeghi
    Department of Life Sciences, Nutritional Sciences Research Division, Franklin Wilkins Building, Kings College London, 150 Stamford Street, London SE1 9NN, UK
    Cell 122:789-801. 2005
    Dietary heme iron is an important nutritional source of iron in carnivores and omnivores that is more readily absorbed than non-heme iron derived from vegetables and grain...
  28. ncbi Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin
    Christian A Schaer
    Department of Medicine, University Hospital, Zurich, Switzerland
    Circ Res 99:943-50. 2006
    b>Heme toxicity contributes to the pathogenesis of chronic inflammatory diseases, atherosclerosis, and hemolysis associated vasculopathy...
  29. pmc A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cell Host Microbe 1:109-19. 2007
    ..We describe the heme sensor system (HssRS) that responds to heme exposure and activates expression of the heme-regulated transporter (..
  30. pmc Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
    Srilatha Raghuram
    Department of Pharmacology and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0733, USA
    Nat Struct Mol Biol 14:1207-13. 2007
    ..Here we show that heme is a physiological ligand of both receptors...
  31. ncbi Characterization of heme as activator of Toll-like receptor 4
    Rodrigo T Figueiredo
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, RJ, Brazil
    J Biol Chem 282:20221-9. 2007
    b>Heme is an ancient and ubiquitous molecule present in organisms of all kingdoms, composed of an atom of iron linked to four ligand groups of porphyrin...
  32. ncbi Carbon monoxide: endogenous production, physiological functions, and pharmacological applications
    Lingyun Wu
    Department of Biology, Lakehead University, 955 Oliver Rd, Thunder Bay, Ontario, Canada P7B 5E1
    Pharmacol Rev 57:585-630. 2005
    ..The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO)...
  33. ncbi Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress
    Qing Lin
    Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 282:20621-33. 2007
    b>Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is an integral membrane protein of the smooth endoplasmic reticulum...
  34. pmc The Mannoprotein Cig1 supports iron acquisition from heme and virulence in the pathogenic fungus Cryptococcus neoformans
    Brigitte Cadieux
    Michael Smith Laboratories and Department of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada
    J Infect Dis 207:1339-47. 2013
    ..Indeed, loss of Cig1 resulted in delayed growth on heme at physiological pH...
  35. pmc Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias
    Jane Jane Chen
    Harvard Massachusetts Institute of Technology MIT Division of Health Sciences and Technology HST, MIT, Cambridge, MA 02139, USA
    Blood 109:2693-9. 2007
    ..differentiation and maturation, it is critical that the 3 components of hemoglobin, alpha-globin, beta-globin, and heme, are made in proper stoichiometry to form stable hemoglobin...
  36. ncbi Structural biology of bacterial iron uptake
    Karla D Krewulak
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Biochim Biophys Acta 1778:1781-804. 2008
    ..for iron, bacteria utilize various iron sources which include the host proteins transferrin and lactoferrin, heme, and low molecular weight iron chelators termed siderophores...
  37. pmc Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme
    M Milani
    Department of Physics INFM and Advanced Biotechnology Center IST, University of Genova, Largo Rosanna Benzi 10 16132 Genova, Italy
    EMBO J 20:3902-9. 2001
    ..In the absence of a polar distal E7 residue, the O2 heme ligand is stabilized by two hydrogen bonds to TyrB10(33)...
  38. ncbi Mosaic origin of the heme biosynthesis pathway in photosynthetic eukaryotes
    Miroslav Obornik
    Department of Botany, University of British Columbia, Vancouver, BC, Canada
    Mol Biol Evol 22:2343-53. 2005
    b>Heme biosynthesis represents one of the most essential metabolic pathways in living organisms, providing the precursors for cytochrome prosthetic groups, photosynthetic pigments, and vitamin B(12)...
  39. pmc Shigella dysenteriae ShuS promotes utilization of heme as an iron source and protects against heme toxicity
    Elizabeth E Wyckoff
    The University of Texas, Section of Molecular Genetics and Microbiology, 1 University Station A5000, Austin, TX 78712 0162, USA
    J Bacteriol 187:5658-64. 2005
    Shigella dysenteriae serotype 1, a major cause of bacillary dysentery in humans, can use heme as a source of iron...
  40. ncbi Mechanisms of cell protection by heme oxygenase-1
    Raffaella Gozzelino
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Annu Rev Pharmacol Toxicol 50:323-54. 2010
    b>Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe(2+), carbon monoxide (CO), and biliverdin...
  41. ncbi Pro-oxidant and cytotoxic effects of circulating heme
    Viktoria Jeney
    Department of Medicine, University of Debrecen, Hungary
    Blood 100:879-87. 2002
    Numerous pathologies may involve toxic side effects of free heme and heme-derived iron...
  42. pmc Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts
    João M P Alves
    Department of Microbiology and Immunology and the Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e23518. 2011
    It has been known for decades that some insect-infecting trypanosomatids can survive in culture without heme supplementation while others cannot, and that this capability is associated with the presence of a betaproteobacterial ..
  43. pmc Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis
    Alex D Sheftel
    Institut fur Zytobiologie, Philipps Universitat Marburg, Robert Koch Strasse 6, 35033 Marburg, Germany
    Proc Natl Acad Sci U S A 107:11775-80. 2010
    ..and its yeast adrenodoxin homologue (Yah1) suggested that Fdx1, like Yah1, may be involved in the biosynthesis of heme A and Fe/S clusters, two versatile and essential protein cofactors...
  44. ncbi Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite
    A V Pandey
    Malaria Research Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, P O Box 10504, New Delhi 110 067, India
    J Biol Chem 274:19383-8. 1999
    ..least in part, exert their effect by interfering with the plasmodial hemoglobin catabolic pathway and inhibition of heme polymerization...
  45. pmc Body iron stores and heme-iron intake in relation to risk of type 2 diabetes: a systematic review and meta-analysis
    Zhuoxian Zhao
    Department of Endocrinology and Metabolism, Sichuan University, West China Hospital, Chengdu, China
    PLoS ONE 7:e41641. 2012
    Emerging evidence from biological and epidemiological studies has suggested that body iron stores and heme-iron intake may be related to the risk of type 2 diabetes (T2D)...
  46. pmc Dietary intakes of zinc and heme iron from red meat, but not from other sources, are associated with greater risk of metabolic syndrome and cardiovascular disease
    Marcia C de Oliveira Otto
    Division of Epidemiology, Human Genetics and EnvFemental Sciences, The University of Texas Health Sciences Center Houston, USA
    J Nutr 142:526-33. 2012
    ..78 (95% CI = 0.62, 0.97), P-trend = 0.01; CVD: HR = 0.69 (95% CI = 0.46, 1.03), P-trend = 0.04]. Intakes of heme iron and Zn from red meat, but not from other sources, were positively associated with risk of MetS [heme iron from ..
  47. pmc Absorption of iron from ferritin is independent of heme iron and ferrous salts in women and rat intestinal segments
    Elizabeth C Theil
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    J Nutr 142:478-83. 2012
    ..Ferritin iron is absorbed by a different mechanism than iron salts/chelates or heme iron...
  48. pmc Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing
    Ian Barr
    Department of Biological Chemistry, David Geffen School of Medicine, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:1919-24. 2012
    ..Previous work showed that DGCR8 forms a highly stable and active complex with ferric [Fe(III)] heme using two endogenous cysteines as axial ligands...
  49. ncbi Heme is involved in microRNA processing
    Michael Faller
    Department of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles UCLA, Los Angeles, California 90095, USA
    Nat Struct Mol Biol 14:23-9. 2007
    ..the RNA-binding protein DiGeorge critical region-8 (DGCR8), which is essential for the first processing step, is a heme-binding protein. The association with heme promotes dimerization of DGCR8...
  50. pmc A robust and extracellular heme-containing peroxidase from Thermobifida fusca as prototype of a bacterial peroxidase superfamily
    Edwin van Bloois
    Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747, AG, Groningen, The Netherlands
    Appl Microbiol Biotechnol 86:1419-30. 2010
    DyP-type peroxidases comprise a novel superfamily of heme-containing peroxidases which is unrelated to the superfamilies of known peroxidases and of which only a few members have been characterized in some detail...
  51. ncbi Identification of the receptor scavenging hemopexin-heme complexes
    Vibeke Hvidberg
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Blood 106:2572-9. 2005
    b>Heme released from heme-binding proteins on internal hemorrhage, hemolysis, myolysis, or other cell damage is highly toxic due to oxidative and proinflammatory effects...
  52. ncbi Heme oxygenase and heme degradation
    Goro Kikuchi
    Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 338:558-67. 2005
    The microsomal heme oxygenase system consists of heme oxygenase (HO) and NADPH-cytochrome P450 reductase, and plays a key role in the physiological catabolism of heme which yields biliverdin, carbon monoxide, and iron as the final ..
  53. pmc Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1
    K Ogawa
    Laboratory of Environmental Biology, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    EMBO J 20:2835-43. 2001
    b>Heme controls expression of genes involved in the synthesis of globins and heme...
  54. ncbi Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues
    K A Nath
    Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 70:432-43. 2006
    b>Heme oxygenase (HO) is the rate-limiting enzyme in the degradation of heme, converting heme to biliverdin, during which iron is released and carbon monoxide (CO) is emitted; biliverdin is subsequently converted to bilirubin by biliverdin ..
  55. ncbi The biochemistry of heme biosynthesis
    Ilka U Heinemann
    Institute of Microbiology, Technical University of Braunschweig, Spielmannstr 7, D 38106 Braunschweig, Germany
    Arch Biochem Biophys 474:238-51. 2008
    b>Heme is an integral part of proteins involved in multiple electron transport chains for energy recovery found in almost all forms of life...
  56. ncbi Free heme toxicity and its detoxification systems in human
    Sanjay Kumar
    Division of Drug Target Discovery and Development, Central Drug Research Institute, Chatter Manzil Palace, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India
    Toxicol Lett 157:175-88. 2005
    ..pathological states, such as sickle cell disease, ischemia reperfusion, and malaria results in high levels of free heme, causing undesirable toxicity leading to organ, tissue, and cellular injury...
  57. ncbi New and classic families of secreted fungal heme peroxidases
    Martin Hofrichter
    Department of Environmental Biotechnology, International Graduate School of Zittau, Markt 23, 02763, Zittau, Germany
    Appl Microbiol Biotechnol 87:871-97. 2010
    b>Heme-containing peroxidases secreted by fungi are a fascinating group of biocatalysts with various ecological and biotechnological implications...
  58. pmc TonB-dependent systems of uropathogenic Escherichia coli: aerobactin and heme transport and TonB are required for virulence in the mouse
    A G Torres
    Department of Microbiology and the Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Infect Immun 69:6179-85. 2001
    The uropathogenic Escherichia coli strain CFT073 has multiple iron acquisition systems, including heme and siderophore transporters...
  59. ncbi Heme oxygenase-1: from biology to therapeutic potential
    Miguel P Soares
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 60, 2780 156, Oeiras, Portugal
    Trends Mol Med 15:50-8. 2009
    b>Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into carbon monoxide, iron (which induces the expression of heavy-chain ferritin, an iron-sequestering protein) and biliverdin (which is converted to ..
  60. ncbi Heme scavenging and the other facets of hemopexin
    Emanuela Tolosano
    Molecular Biotechnology Center, University of Torino, Torino, Italy
    Antioxid Redox Signal 12:305-20. 2010
    ..is an acute-phase plasma glycoprotein, produced mainly by the liver and released into plasma, where it binds heme with high affinity. Other sites of hemopexin synthesis are the nervous system, skeletal muscle, retina, and kidney...
  61. ncbi Products of heme oxygenase and their potential therapeutic applications
    Kristin A Kirkby
    The Comparative Nephrology and Transplantation Laboratory, Dept of Small Animal Clinical Sciences, Veterinary Medical Teaching Hospital, PO Box 100126, Univ of Florida, Gainesville, FL 32610 0126, USA
    Am J Physiol Renal Physiol 290:F563-71. 2006
    b>Heme oxygenase 1 (HO-1) is induced in response to cellular stress and is responsible for converting the prooxidant heme molecule into equimolar quantities of biliverdin (BV), carbon monoxide (CO), and iron...
  62. ncbi Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts
    Kenichiro Yamashita
    Department of Surgery, Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215, USA
    FASEB J 18:765-7. 2004
    Biliverdin, a product of heme oxygenase-1 (HO-1) enzymatic action, is converted into bilirubin, which has been considered a waste product in the past...
  63. pmc Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    Johannes Peter Stasch
    Institute of Cardiovascular Research, Bayer HealthCare, Wuppertal, Germany
    J Clin Invest 116:2552-61. 2006
    ..Increased oxidative stress affects the heme-containing NO receptor sGC by both decreasing its expression levels and impairing NO-induced activation, making ..
  64. pmc Gestational diabetes mellitus in relation to maternal dietary heme iron and nonheme iron intake
    Chunfang Qiu
    Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington, USA
    Diabetes Care 34:1564-9. 2011
    Higher heme iron intake is associated with increased type 2 diabetes risk. However, no previous study has evaluated gestational diabetes mellitus (GDM) risk in relation to heme iron intake during pregnancy...
  65. ncbi Identification and characterization of a novel vitamin B12 (cobalamin) biosynthetic enzyme (CobZ) from Rhodobacter capsulatus, containing flavin, heme, and Fe-S cofactors
    Helen M McGoldrick
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 280:1086-94. 2005
    ..CobZ, allowed the characterization of a novel cofactor-rich protein, housing two Fe-S centers, a flavin, and a heme group, which like B12 itself is a modified tetrapyrrole...
  66. pmc Roles of iron acquisition systems in virulence of extraintestinal pathogenic Escherichia coli: salmochelin and aerobactin contribute more to virulence than heme in a chicken infection model
    Qingqing Gao
    Animal Infectious Disease Laboratory, Ministry of Education Key Lab for Avian Preventive Medicine, College of Veterinary Medicine, Yangzhou University, Jiangsu, People s Republic of China
    BMC Microbiol 12:143. 2012
    ..coli (ExPEC). Both types have multiple iron acquisition systems, including heme and siderophores...
  67. pmc PpsR, a regulator of heme and bacteriochlorophyll biosynthesis, is a heme-sensing protein
    Liang Yin
    Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405, USA
    J Biol Chem 287:13850-8. 2012
    b>Heme-mediated regulation, presented in many biological processes, is achieved in part with proteins containing heme regulatory motif...
  68. pmc Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration
    Sumanta Dey
    Division of Infectious Diseases and Immunology, Council of Scientific and Industrial Research Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, West Bengal, India
    J Biol Chem 287:26630-46. 2012
    ..hemolysis showed a positive correlation with liver damage along with the increased accumulation of free heme and reactive oxidants in liver...
  69. pmc Identification and characterization of a Streptococcus pyogenes operon involved in binding of hemoproteins and acquisition of iron
    Christopher S Bates
    Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303, USA
    Infect Immun 71:1042-55. 2003
    The hemolytic Streptococcus pyogenes can use a variety of heme compounds as an iron source. In this study, we investigate hemoprotein utilization by S. pyogenes...
  70. pmc The Escherichia coli protein YfeX functions as a porphyrinogen oxidase, not a heme dechelatase
    Harry A Dailey
    Biomedical and Health Sciences Institute, University of Georgia, Athens, Georgia, USA
    MBio 2:e00248-11. 2011
    The protein YfeX from Escherichia coli has been proposed to be essential for the process of iron removal from heme by carrying out a dechelation of heme without cleavage of the porphyrin macrocycle...
  71. ncbi Haem iron-transport system in enterohaemorrhagic Escherichia coli O157:H7
    A G Torres
    Department of Microbiology, University of Texas at Austin 78712, USA
    Mol Microbiol 23:825-33. 1997
    ..A conserved Fur box was identified upstream of the chuA gene, and regulation by Fur was confirmed...
  72. pmc Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition
    Weiguo Chen
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 49:3129-37. 2010
    ..Additionally, ONOO(-) triggered changes in the UV/visible spectrum and heme content of the enzyme. Preincubation of eNOS with BH(4) decreased dimer destabilization and heme alteration...
  73. ncbi The cytoplasmic heme-binding protein (PhuS) from the heme uptake system of Pseudomonas aeruginosa is an intracellular heme-trafficking protein to the delta-regioselective heme oxygenase
    Ila B Lansky
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 281:13652-62. 2006
    The uptake and utilization of heme as an iron source is a receptor-mediated process in bacterial pathogens and involves a number of proteins required for internalization and degradation of heme...
  74. ncbi Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging
    Marianne Jensby Nielsen
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Blood 114:764-71. 2009
    Haptoglobin, the haptoglobin-hemoglobin receptor CD163, and the heme oxygenase-1 are proteins with a well-established function in the clearance and metabolism of "free" hemoglobin released during intravascular hemolysis...
  75. pmc Haemophilus influenzae OxyR: characterization of its regulation, regulon and role in fitness
    Paul W Whitby
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 7:e50588. 2012
    ..These findings clearly establish a crucial role for OxyR in bacterial fitness...
  76. pmc Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation
    Patricia L Fernandez
    Laboratório de Inflamação e Imunidade, Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21941 902 Rio de Janeiro, Brazil
    J Biol Chem 285:32844-51. 2010
    ..In these conditions, hemeproteins and heme are released, but whether heme affects the inflammatory response to microorganism molecules remains to be ..
  77. pmc Heme, a plastid-derived regulator of nuclear gene expression in Chlamydomonas
    Erika D von Gromoff
    Fakultat fur Biologie, Institut fur Biologie III, Universitat Freiburg, D 79104 Freiburg, Germany
    Plant Cell 20:552-67. 2008
    ..The four mutants lack chlorophyll and show reduced levels of Mg-tetrapyrroles but increased levels of soluble heme. In the mutants, light induction of HSP70A was preserved, although Mg-protoporphyrin IX has been implicated in this ..
  78. ncbi Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved
    Nadia M Bastide
    INRA TOXALIM Research Centre in Food Toxicology, Université de Toulouse INP ENVT, Toulouse, France
    Cancer Prev Res (Phila) 4:177-84. 2011
    ..Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer...
  79. pmc IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge
    Hwan Keun Kim
    Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL, USA
    Vaccine 28:6382-92. 2010
    ..Antibodies directed against IsdA interfered with heme-binding and IsdB antibodies perturbed the ability of this surface protein to bind hemoglobin...
  80. ncbi The heme oxygenase system: update 2005
    Mahin D Maines
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14624, USA
    Antioxid Redox Signal 7:1761-6. 2005
  81. ncbi Heme impairs prostaglandin E2 and TGF-beta production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria
    Bruno B Andrade
    Centro de Pesquisas Gonçalo Moniz Fundação Oswaldo Cruz, Salvador, Bahia, Brazil
    J Immunol 185:1196-204. 2010
    In many hemolytic disorders, such as malaria, the release of free heme has been involved in the triggering of oxidative stress and tissue damage. Patients presenting with severe forms of malaria commonly have impaired regulatory responses...
  82. pmc Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis
    Roland Nilsson
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 10:119-30. 2009
    b>Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria...
  83. ncbi The structure of cbb3 cytochrome oxidase provides insights into proton pumping
    Sabine Buschmann
    Max Planck Institut fur Biophysik, Max von Laue Strasse 3, D 60438 Frankfurt Main, Germany
    Science 329:327-30. 2010
    The heme-copper oxidases (HCOs) accomplish the key event of aerobic respiration; they couple O2 reduction and transmembrane proton pumping...
  84. ncbi Heme proteins--diversity in structural characteristics, function, and folding
    Lorna J Smith
    Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, Oxford OX1 3QR, United Kingdom
    Proteins 78:2349-68. 2010
    The characteristics of heme prosthetic groups and their binding sites have been analyzed in detail in a data set of nonhomologous heme proteins...
  85. ncbi Neutrophil activation by heme: implications for inflammatory processes
    Aurelio V Graca-Souza
    Departamento de Farmacologia, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Brazil
    Blood 99:4160-5. 2002
    b>Heme, a ubiquitous iron-containing compound, is present in large amounts in many cells and is inherently dangerous, particularly when it escapes from intracellular sites...
  86. ncbi Identification of the Aedes aegypti peritrophic matrix protein AeIMUCI as a heme-binding protein
    Martin Devenport
    Department of Molecular Microbiology and Immunology and Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA
    Biochemistry 45:9540-9. 2006
    ..Previous experiments suggested that the Ae. aegypti PM can bind toxic heme molecules generated during blood digestion. However, the identity of the binding molecule(s) was unknown...
  87. ncbi Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3
    W K McCoubrey
    University of Rochester School of Medicine and Dentistry, Department of Biochemistry Biophysics, NY 14642, USA
    Eur J Biochem 247:725-32. 1997
    Two isozymes of heme oxygenase (HO), HO-1 or HSP32 and the constitutive form HO-2, have been characterized to date. We report the discovery of a third protein species and refer to it as HO-3...
  88. ncbi Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors
    Bárbara N Porto
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, RJ, 21 941 590 Brasil
    J Biol Chem 282:24430-6. 2007
    Hemolysis or extensive cell damage can lead to high concentrations of free heme, causing oxidative stress and inflammation...
  89. pmc Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
    Wen Xie
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 100:4150-5. 2003
    ..regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs...
  90. ncbi Dietary iron intake and Type 2 diabetes incidence in postmenopausal women: the Iowa Women's Health Study
    D H Lee
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Diabetologia 47:185-94. 2004
    ..Recently, a clear biological link between iron metabolism and diabetes has emerged from epidemiological and experimental studies. We carried out a prospective study of dietary iron intake and incidence of Type 2 diabetes...
  91. ncbi Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress
    Zulfiqar Ahmad
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 277:9226-32. 2002
    Human biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin...
  92. ncbi Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1
    K A Nath
    Nephrology Research Unit, Departments of Pathology and Immunology, Mayo Clinic/Foundation, Rochester, MN 55905, USA
    Kidney Int 59:106-17. 2001
    BACKGROUND: Heme oxygenase (HO) is the rate-limiting enzyme in the degradation of heme; its inducible isozyme, HO-1, protects against acute heme protein-induced nephrotoxicity and other forms of acute tissue injury...
  93. ncbi Cerebral malaria and the hemolysis/methemoglobin/heme hypothesis: shedding new light on an old disease
    Ana Pamplona
    Unidade de Malaria, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisboa, Portugal
    Int J Biochem Cell Biol 41:711-6. 2009
    ..In this review, we discuss the role of hemolysis, methemoglobin and free heme in CM, brought to light by our recent studies in mice as well as by other studies in humans.
  94. pmc The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target
    Bo Wu
    Division of Molecular Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
    PLoS Negl Trop Dis 3:e475. 2009
    ..Human trials have confirmed this approach, although the length of treatments, high doses required and medical counter-indications for young children and pregnant women warrant the identification of additional anti-Wolbachia drugs...
  95. ncbi A central role for free heme in the pathogenesis of severe malaria: the missing link?
    Ana Ferreira
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    J Mol Med (Berl) 86:1097-111. 2008
    ..survival of a Plasmodium-infected host is strictly dependent on the host's ability to up-regulate the expression of heme oxygenase-1 (HO-1 encoded by the gene Hmox1)...
  96. ncbi Hemoglobin and heme scavenger receptors
    Marianne Jensby Nielsen
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Antioxid Redox Signal 12:261-73. 2010
    b>Heme, the functional group of hemoglobin, myoglobin, and other hemoproteins, is a highly toxic substance when it appears in the extracellular milieu...
  97. ncbi Iron regulatory proteins secure mitochondrial iron sufficiency and function
    Bruno Galy
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell Metab 12:194-201. 2010
    Mitochondria supply cells with ATP, heme, and iron sulfur clusters (ISC), and mitochondrial energy metabolism involves both heme- and ISC-dependent enzymes...
  98. pmc Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
    Abbhirami Rajagopal
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    Nature 453:1127-31. 2008
    ..Thus, uncovering the mechanisms of haem transport in C. elegans may provide insights into human disorders of haem metabolism and reveal new drug targets for developing anthelminthics to combat worm infestations...
  99. ncbi Heme oxygenase system in ischemia and reperfusion injury
    Sei Ichiro Tsuchihashi
    Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Ann Transplant 9:84-7. 2004
    ..The heme oxygenase-1 (HO-1) system is among the most critical of cytoprotective mechanisms activated during the cellular ..
  100. pmc Iron and porphyrin trafficking in heme biogenesis
    Iman J Schultz
    Department of Medicine, Hematology Division, Brigham and Women s Hospital, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:26753-9. 2010
    ..In mammals, the majority of iron is enclosed within a single prosthetic group: heme. In metazoans, heme is synthesized via a highly conserved and coordinated pathway within the mitochondria...
  101. pmc Leishmania pifanoi amastigotes avoid macrophage production of superoxide by inducing heme degradation
    Nam Kha Pham
    Department of Microbiology and Cell Science, Building 981, Box 110700, University of Florida, Gainesville, FL 32611, USA
    Infect Immun 73:8322-33. 2005
    ..Given that gp91phox maturation is dependent on the availability of heme, we found that infections by Leishmania parasites induce an increase in heme oxygenase 1 (HO-1), the rate-limiting ..

Research Grants72

  1. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..A/I + T3) Several molecules and enzymes were overexpressed in the untreated A/I kidney including NADPH oxidase, heme-oxygenase-1 (HO-1),, and ERK 1/2 phosphorylation and functional nitric oxide activity was decreased...
  2. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..Initial exploration of mechanisms will include altered heme and NAD levels, the latter resulting in altered AMPK signaling.
  3. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..We will perform experiments to determine the role of a metazoan siderophore in heme biogenesis and in blood cell lineage specification in developing zebrafish embryos (Aim 3)...
  4. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Evidence implicates a role for heme-containing peroxidase in atherogenesis due in part to oxidation of low density lipoprotein (LDL)...
  5. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ..provided by applicant): The long-term objective of the proposed studies is to define the mechanisms of mammalian heme transport and utilization at the cellular level, and the impact of heme cellular pathways on nutritional iron ..
  6. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    ..On the other hand, plasma free heme has been incriminated in the genesis of CM...
    John J Lemasters; Fiscal Year: 2012
    ..MPT inhibition, decreased oxidative stress, decreased nonparenchymal cell injury and increased expression of heme oxygenase-1 (HO-1)...
  8. Mechanistic Characterization and Genetic Analysis of Systemic Iron Homeostasis
    Xin Du; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): As a component of heme and a constituent of many iron-dependent enzymes, iron is essential for oxidative phosphorylation, erythropoiesis, and many other chemical reactions that are vital for survival ..
  9. Vaccine Assembly from Surface Proteins of Staphylococcus Aureus
    Olaf Schneewind; Fiscal Year: 2013
    ..Research conducted under NIAID AI52747 studied the molecular biology of heme-iron scavenging in staphylococci and identified the molecular properties of iron-regulated surface determinants (..
  10. Regulation of insulator function and globin gene expression by USF and associated
    Suming Huang; Fiscal Year: 2013
    ..depends on hemoglobin, a heterotetramer composed of two a and two -globin chains and associated iron-binding heme groups...
  11. Iron, NO, and Lipid Peroxide in Photodynamic Therapy
    ALBERT GIROTTI; Fiscal Year: 2013
    ..protect tumor cells against necrotic photokilling by either scavenging lipid-derived radicals or by signaling for heme oxygenase-1 and ferritin induction, leading to depletion of prooxidant iron...
  12. Nitric Oxide Signaling with Heme Proteins
    William R Montfort; Fiscal Year: 2012
    This proposal is for the second competitive renewal of grant HL62969, focusing on the biophysics of nitrosyl heme chemistry and its role in nitric oxide (NO) signaling...
  13. Electron Transfer in Iron and Copper Proteins
    Jay R Winkler; Fiscal Year: 2013
    ..Important members of this class of enzymes are the heme-thiolate mono- oxygenases such as cytochrome P450 and nitric oxide synthases (NOS)...
  14. Human Heme Oxygenase-1 Gene Regulation in Renal Injury
    Anupam Agarwal; Fiscal Year: 2012
    ..objectives of this proposal are to understand the molecular mechanisms that regulate expression of the human heme oxygenase-1 (HO-1) gene in acute kidney injury...
  15. Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium as a Model for A
    Alfred S Lewin; Fiscal Year: 2013
    ..We will attempt to counteract mitochondrial oxidative stress by elevating a set of antioxidant enzymes, including heme oxygenase-1, glutathione transferases, and NAD(P)H:quinone oxidoreductase 1...
  16. Biosynthetic Protein Models of Heme-copper Oxidases and Nitric Oxide Reductases
    Yi Lu; Fiscal Year: 2013
    ..e., why a protein is proficient at O-O bond cleavage when using a heme-copper center as in heme-copper oxidases (HCO), and is effective at N-N bond formation when using a heme-non-heme ..
  17. Understand and Improve Iron Distribution and Erythropoiesis in Beta-Thalassemia
    Yelena Ginzburg; Fiscal Year: 2013
    ..that supplemental transferrin results in more iron deficient erythropoiesis, reducing the imbalance between heme, alpha-globin, and beta-globin synthesis in beta-thalassemia...
  18. Influence of Heme on Hepatic Cytochrome P450 Turnover
    Maria Almira Correia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute hepatic heme deficiency is a biochemical hallmark of acute clinical attacks of hepatic porphyrias, genetic disorders stemming from inherited defects in heme synthesis...
  19. Mechanisms of endothelial barrier phenotypes in sickle cell disease
    ..Currently, the vascular disease process involving hypoxia, free heme and ischemia reperfusion in SCD are not well understood...
  20. Effect of Maspin on Corneal Heme-and lymph- angiogenesis
    Sally S Twining; Fiscal Year: 2013
    ..The Specific Objectives are: 1) To test the hypothesis that maspin alters heme and lymph-angiogenesis by multiple mechanisms involving both direct effects on vascular and lymph endothelial cells ..
  21. Role of surface proteins in sand fly colonization by Bartonella bacilliformis
    Michael F Minnick; Fiscal Year: 2013
    ..We also propose to examine the role of three putative virulence determinants [i.e., flagellin (FlaA), heme-binding protein C (HbpC) and the invasion-associated locus B (IalB) protein] in Bb's colonization of L...
  22. Pathogenesis of cognitive/neurologic deficits in central nervous system malaria
    Chandy C John; Fiscal Year: 2012
    ..reactive oxygen (ROS) and nitrogen (RNS) species, and pro- and anti- inflammatory cytokines, and leukocyte heme oxygenase-1 (HO-1) expression;b) markers of central nervous system inflammation (e.g...
  23. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    ..pneumoniae which represses the synthesis of the Piu heme transporter, and (3) Ser/Thr kinase and phosphatase are required for Piu heme transporter expression...
  24. Role of Mitochondria Targeted CYP2E1 and HO-1 in Alcohol Mediated Tissue Injury
    Narayan G Avadhani; Fiscal Year: 2012
    Cytochrome P4502E1 (CYP2E1) and inducible heme oxygenase 1 (HO-1) and a number of other proteins are bimodally targeted to mitochondria in addition to their well-established ER or cytoplasmic destination...
  25. Molecular &Cellular Effects of Human Mutations in Cytochrome P450 Reductase
    Satya Prakash Panda; Fiscal Year: 2013
    ..P450 oxidoreductase (POR) is the sole provider of electrons to the microsomal cytochromes P450 and to heme oxygenase, which catabolizes heme degradation...
  26. Haemophilus influenzae iron/heme regulon
    Terrence L Stull; Fiscal Year: 2012
    ..H. influenzae has an absolute growth requirement for heme and the human body is its sole niche. We have characterized several of the heme and iron acquisition systems of H...
  27. Heme Oxygenase Enzymes/Carbon Monoxide in Hepatic Dysfunction from hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..CO is produces endogenously in the breakdown of heme by heme oxygenase enzymes and has been shown to possess significant anti-inflammatory properties...
    Marcos Intaglietta; Fiscal Year: 2011
    ..In this present application we will test the hypothesis that MP4 is an effective carrier of the heme ligands O2, carbon monoxide (CO)and nitric oxide (NO), and will carry out the related physiological studies in ..
  29. Novel Catalases and their Products
    Alan R Brash; Fiscal Year: 2013
    ..AOS and the P450 type of AOS to monooxygenases will be examined using surrogate oxygen donors to activate the heme, with stopped flow spectral recording to detect short-lived intermediates as well as detailed product analysis to ..
  30. Tyrosinase Model Complexes using Imidazole Ligands
    JOHN BRANNON GARY; Fiscal Year: 2013
    ..Such findings of the biological relevance of Cu(III) would provide a complete paradigm shift in copper biochemistry (e.g. Fe(IV)-oxo intermediates for non-heme iron sites).
  31. H. pylori induced DNA Damage and Immune Dysregulation
    Keith T Wilson; Fiscal Year: 2013
    ..We have also discovered another target of H. pylori, heme oxygenase (HO)-1, known for its anti-inflammatory and anti-oxidant properties. We show that H...
  32. Redox Regulation of Lung Mitochondrial Biogenesis in Sepsis/Pneumonia
    Claude A Piantadosi; Fiscal Year: 2013
    ..genomic transcriptional network of mitochondrial biogenesis, which is strongly activated by the induction of the heme oxygenase-1/carbon monoxide system (HO-1/CO) to protect energy metabolism and mitochondrial mass, but which we ..
  33. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    ..Therefore, identifying protective mechanisms will be critical to the development of effective interventions. Heme oxygenase-1 (HO-1) is an important protective molecule but the underlying molecular mechanisms and responsible cell ..
  34. Nonheme Diiron Centers and the Biological Oxidation of Hydrocarbons
    Stephen J Lippard; Fiscal Year: 2013
    ..is to understand the activation of oxygen and subsequent selective oxidation of hydrocarbons that occurs at non-heme diiron centers in the hydroxylase enzymes of bacterial multicomponent monooxygenases (BMMs)...
    L Jackson Roberts; Fiscal Year: 2010
    ..Project 3 builds on findings that acetaminophen inhibits heme protein-catalyzed lipid peroxidation and will determine the molecular basis for this effect...
  36. Problems in Membrane Protein Crystallography: Hetero-Oligomeric Cytochrome b6f
    William A Cramer; Fiscal Year: 2012
    ..Structure-function analysis would focus on the properties of a unique redox group, heme cn, and on the mechanism of transfer across the membrane of quinone (ol) that carries the electrons and protons and ..
  37. Mechanisms that Regulate Neonatal Lung Heme Oxygenase in Hyperoxia
    Phyllis A Dennery; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The newborn is more tolerant to hyperoxia than adults. Heme oxygenase, in particular the inducible form, is highly expressed in the neonatal lung...
  38. Rev-ERBa Regulates Mitochondrial Biogenesis, Adiposity, and Insulin Action
    Thomas H Reynolds; Fiscal Year: 2010
    ..By treating obese mice with the manganese tetrakis benzoic acid (MnTBA) porphyrin, we have identified heme's nuclear receptor, Rev-ERBa, as a novel anti- obesity target that also improves insulin action...
  39. Heme trafficking and its impact on systemic iron homeostasis
    Janis L Abkowitz; Fiscal Year: 2010
    The goal of this project is to study how heme trafficking might impact systemic iron homeostasis...
  40. Heme Oxygenase Polymorphisms and Hepatopulmonary Syndrome
    KARI EVAN ROBERTS; Fiscal Year: 2012
    ..Recent evidence from animal and human HPS implicates abnormal heme oxygenase and carbon monoxide signaling in the disease process...
  41. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley E Britigan; Fiscal Year: 2013
    ..tb Fe uptake. Whether other factors that regulate macrophage Fe metabolism (e.g. ferroportin, heme oxygenase 1 (HO-1), hepcidin) impact M.tb Fe acquisition is unknown...
  42. Heme trafficking and its impact on systemic iron homeostasis
    Janis L Abkowitz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this project is to study how heme trafficking might impact systemic iron homeostasis...
  43. A Comparative Approach to Globin Regulation/Thalassemia
    LEONARD IRA ZON; Fiscal Year: 2012
    ..These factors fall into four categories: the production of heme, iron utilization, globin expression, and iron sulfur cluster production...
  44. Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosis
    Paul R Ortiz de Montellano; Fiscal Year: 2013
    ..tuberculosis. We have demonstrated that the sensors are heme proteins, defined the differential response to the various gases, and determined the crystal structure of DosT...
  45. The Transport of Nutritional Heme in Animal Development
    Iqbal Hamza; Fiscal Year: 2013
    ..by applicant): The long-term objective of our studies is to define the cellular and molecular determinants of heme homeostasis in human nutrition. Iron deficiency is the most common nutritional disorder...
  46. Isoform specific effects of the autoinhibitory element and the C-terminus of nitr
    JOHN SALERNO; Fiscal Year: 2009
    ..NOS is a large modular enzyme with a heme containing oxygenase domain and a three domain reductase component...
  47. Blood Pressure Regulation: Novel Roles for the Kidney
    Pablo A Ortiz; Fiscal Year: 2013
    ..Project 3 will test whether heme oxygenases in the macula densa produce carbon monoxide (CO) and biliverdin, which act synergistically and in an ..
  48. Genome-wide epigenetic control of circadian metabolism by heme receptor Rev-erb
    Mitchell A Lazar; Fiscal Year: 2010
    ..The heme receptor Rev-erb was identified by the PI in 1989, and has since emerged as an important repressor of key genes ..
  49. Neurotoxicity of Magnetic Nanoparticles
    Veronica Shubayev; Fiscal Year: 2010
    ..stable, water soluble and resistant to agglomeration, we observed a robust influx of macrophages, activation of heme oxygenase-1, interleukin-12, matrix metalloproteinase (MMP)-9 and caspase 3, all consistent with the oxidative ..
  50. Nitrite Mediated Cardioprotection
    DAVID JOSEPH LEFER; Fiscal Year: 2012
    ..nitrite intake significantly alter steady-state concentrations of nitrite, nitroso modified proteins, and nitrosyl-heme products and that these biochemical changes have a profound outcome on the severity of acute myocardial infarction...
  51. Zebrafish Genetics to Identify Genes Involved in Hematopoiesis
    DHVANIT INDRAVADAN SHAH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this project is to offer novel insights into heme synthesis and hematopoietic pathways that can improve treatment of congenital and acquired anemia...
  52. Mitochondrial Modulation of Endothelia Function
    John F Keaney; Fiscal Year: 2013
    ..provided by applicant): Mitochondria are known to participate in a host of cellular processes such as apoptosis, heme metabolism, and the regulation of energy balance...
    Paul R Ortiz de Montellano; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heme oxygenases (HOs) oxidize heme to biliverdin, iron, and carbon monoxide (CO) via a complex, three-stage process that requires seven electrons and three molecules of O2...
  54. New mechanism and regulation of intracellular heme delivery in mammals
    Dennis J Stuehr; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heme proteins play vital roles in physiology and medicine...
    FRANCES ANN WALKER; Fiscal Year: 2012
    ..river basin, which carries the parasite Trypanasoma cruzi, the vector of Chagas'disease, contains a suite of heme proteins that we have named Nitrophorins (NPs)...
    Curtis J Omiecinski; Fiscal Year: 2013
    ..with exposures to drugs, other xenobiotics, and endogenous substances such as bile acids, thyroid hormone, heme, and steroids...
  57. Acute Renal Failure: Mechanisms and Adaptive Responses
    Richard A Zager; Fiscal Year: 2013
    ..we have identified "activating" histone changes at specific genes that participate in both acquired cytoresistance (heme oxygenase 1, HMG CoA reductase), and the hyper-inflammatory state (TNF-a;MCP-1)...
  58. Mechanisms of Neurotransmitter Biosynthesis
    Paul F Fitzpatrick; Fiscal Year: 2011
    Phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase make up the family of non-heme iron pterin-dependent aromatic amino acid hydroxylases...
  59. Novel strategy to mitigate and treat radiation combined infection injury by targe
    Shyam Biswal; Fiscal Year: 2012
    ..of NRF2 and transcriptional induction of antioxidant genes - glutathione pathway, thioredoxin pathway, heme oxygenase-1, several protective pathways that collectively protect against oxidative stress and macromolecular ..
  60. Heme, Iron and Oxidative Stress: Regulation of Iron Homeostasis in H. Influenzae
    Robert S Munson; Fiscal Year: 2013
    ..Although iron and heme uptake systems have been identified in NTHi, little is known about how iron and heme uptake is regulated...
  61. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
    ..SNPs) of interest exist in NF-E2, related factor 2 (NRF2), GSTP1, GSTT1, glutathione peroxdiase (GPX1), Heme oxygenase-1 (HO-1), and Superoxidase dismutase 2 (SOD2), theCD14 gene promoter, TLR2, TLR4;IL-1 , IL-1R, and the ..
  62. Mechanism of heme regulation of a P. aeruginosa non-coding RNA
    ..aeruginosa requires iron and employs several strategies for its acquisition, including the uptake of heme. Although required for survival, surplus iron or heme can lead to oxidative stress;thus, the ferric uptake ..
    Mario Rivera; Fiscal Year: 1999
    ..The PI intends to accomplish the following; 1. Develop the methodology for the bacterial expression of 13C-heme enriched b5 by combining the now elucidated biosynthetic pathway of heme and the special properties built in our ..
  64. Bacterial heme transport and hemoglobin expression
    Douglas Henderson; Fiscal Year: 2009
    ..When hemoglobin is expressed in E. coli, sufficient heme must be available to be added to globin chains, or bacterial proteases degrade them before hemoglobin assembly ..
    GEOFFREY TOMPKINS; Fiscal Year: 1993
    b>Heme- and iron-scavenging systems are important virulence factors among a diversity of pathogenic bacteria...
  66. Nitrogen Oxides and Heme
    GEORGE RICHTER ADDO; Fiscal Year: 2007
    ..The simplest nitrogen oxide, NO (nitric oxide), is a small paramagnetic molecule that binds to heme iron to result in various biological events ranging from vasodilation to the enabling of light flashes in fireflies...
    HERBERT BONKOVSKY; Fiscal Year: 2009
    ..The long-term goal of this research program is to understand the pathways and regulation of hepatic porphyrin and heme metabolism. Heme is a primordial molecule that is of critical importance to life on earth...
  68. Heme Oxygenase and Spinal Cord Injury
    Linda Noble; Fiscal Year: 2004
    ..The proposed studies examine the role of heme oxygenase-1 (HO-1) in both early and delayed injury in the traumatized spinal cord...
    CHARLES LEFFLER; Fiscal Year: 2009
    The gas, carbon monoxide (CO), is produced physiologically by catabolism of heme via heme oxygenase...
    KENNETH SUSLICK; Fiscal Year: 2004
    The objectives of this research involve the characterization and application of heme proteins, heme protein microspheres, and synthetic analogs of heme proteins...
  71. Electronic/Molecular Structure of Enzyme Heme Pockets
    GERD LA MAR; Fiscal Year: 2009
    ..the detailed study of functionally relevant molecular/electronic structural and dynamic properties of a series of heme oxygenase, HO, enzymes and their complexes with substrate/reaction intermediates in variable oxidation/spin/..
    Benjamin Frydman; Fiscal Year: 1990
    b>Heme catabolism in mammals will be studied by using solubilized heme oxygenase and synthetic hemins and will be compared with the results obtained with the membrane bound oxygenase...