deuteroporphyrins

Summary

Summary: Porphyrins with four methyl and two propionic acid side chains attached to the pyrrole rings.

Top Publications

  1. ncbi Magnesium-dependent ATPase activity and cooperativity of magnesium chelatase from Synechocystis sp. PCC6803
    James D Reid
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 279:26893-9. 2004
  2. ncbi Characterization of the binding of deuteroporphyrin IX to the magnesium chelatase H subunit and spectroscopic properties of the complex
    G A Karger
    Robert Hill Institute for Photosynthesis, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Biochemistry 40:9291-9. 2001
  3. ncbi Pharmacokinetics, tissue distribution and excretion of a new photodynamic drug deuxemether
    Rui Wang
    Key Laboratory of Drug Metabolism and Pharmacokinetics, 24 Tong Jia Xiang Street, Mail Box 210, China Pharmaceutical University, Nanjing, Jiangsu 210009, China
    J Photochem Photobiol B 90:179-86. 2008
  4. ncbi Role of the preoptic carbon monoxide pathway in endotoxin fever in rats
    Alexandre A Steiner
    Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirao Preto USP, 14040 904 Ribeirao Preto, SP, Brazil
    Brain Res 927:27-34. 2002
  5. ncbi Enhancing the stability of microsomal cytochrome b5: a rational approach informed by comparative studies with the outer mitochondrial membrane isoform
    Na Sun
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7582, USA
    Protein Eng Des Sel 18:571-9. 2005
  6. ncbi Boron neutron capture therapy for undifferentiated thyroid carcinoma: preliminary results with the combined use of BPA and BOPP
    M Viaggi
    Department of Radiobiology, Constituyentes Atomic Center, Av del Libertador 8250, 1429 Buenos Aires, Argentina
    Appl Radiat Isot 61:905-9. 2004
  7. pmc Equilibrium and kinetic studies of the interactions of a porphyrin with low-density lipoproteins
    Stephanie Bonneau
    Laboratoire de Photobiologie, Museum national d histoire naturelle, 43 rue Cuvier, 75231 Paris Cedex 05, France
    Biophys J 83:3470-81. 2002
  8. ncbi [Development of a new technology of photodynamic destruction of newly formed corneal vessels via local administration of photosensitizers]
    Iu V Andreev
    Vestn Oftalmol 121:21-5. 2005
  9. ncbi [Synthesis of triads based on deuteroporphyrin IX, naphthoquinone, and aromatic amino acids]
    E A Larkina
    Lomonosov State Academy of Fine Chemical Technology, pr Vernadskogo 86, Moscow, 117571 Russia
    Bioorg Khim 28:357-61. 2002
  10. pmc NO orientation and tilting in (nitrosyl)iron(II) deuteroporphyrin IX
    Graeme R A Wyllie
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Inorg Chem 42:4259-61. 2003

Research Grants

  1. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
  2. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003

Scientific Experts

Detail Information

Publications89

  1. ncbi Magnesium-dependent ATPase activity and cooperativity of magnesium chelatase from Synechocystis sp. PCC6803
    James D Reid
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 279:26893-9. 2004
    ....
  2. ncbi Characterization of the binding of deuteroporphyrin IX to the magnesium chelatase H subunit and spectroscopic properties of the complex
    G A Karger
    Robert Hill Institute for Photosynthesis, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Biochemistry 40:9291-9. 2001
    ..The implications of the H-Mg protoporphyrin interaction for the next enzyme in the chlorophyll biosynthetic pathway, Mg protoporphyrin methyltransferase, are discussed...
  3. ncbi Pharmacokinetics, tissue distribution and excretion of a new photodynamic drug deuxemether
    Rui Wang
    Key Laboratory of Drug Metabolism and Pharmacokinetics, 24 Tong Jia Xiang Street, Mail Box 210, China Pharmaceutical University, Nanjing, Jiangsu 210009, China
    J Photochem Photobiol B 90:179-86. 2008
    ..In conclusion, this study provided firstly the full pharmacokinetic characteristics and mechanisms of deuxemether, which would be helpful for its clinical regiment design...
  4. ncbi Role of the preoptic carbon monoxide pathway in endotoxin fever in rats
    Alexandre A Steiner
    Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirao Preto USP, 14040 904 Ribeirao Preto, SP, Brazil
    Brain Res 927:27-34. 2002
    ..In summary, the present results support the idea that the POA is not the brain site where the HO-CO pathway acts as a fever mediator...
  5. ncbi Enhancing the stability of microsomal cytochrome b5: a rational approach informed by comparative studies with the outer mitochondrial membrane isoform
    Na Sun
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7582, USA
    Protein Eng Des Sel 18:571-9. 2005
    ..The results suggest that maximizing heme binding pocket compactness in the apo state is a useful general strategy for increasing the stability of engineered or designed proteins...
  6. ncbi Boron neutron capture therapy for undifferentiated thyroid carcinoma: preliminary results with the combined use of BPA and BOPP
    M Viaggi
    Department of Radiobiology, Constituyentes Atomic Center, Av del Libertador 8250, 1429 Buenos Aires, Argentina
    Appl Radiat Isot 61:905-9. 2004
    ..Two groups of mice received different total absorbed doses: 3.00 and 6.01 Gy, but no further improvement in the outcome was found compared to the previous results using BPA alone (4.3 Gy)...
  7. pmc Equilibrium and kinetic studies of the interactions of a porphyrin with low-density lipoproteins
    Stephanie Bonneau
    Laboratoire de Photobiologie, Museum national d histoire naturelle, 43 rue Cuvier, 75231 Paris Cedex 05, France
    Biophys J 83:3470-81. 2002
    ..The kinetics of porphyrin-LDL interactions indicates that changes in the distribution of photosensitizers among various carriers could be very sensitive to the specific tumor microenvironment...
  8. ncbi [Development of a new technology of photodynamic destruction of newly formed corneal vessels via local administration of photosensitizers]
    Iu V Andreev
    Vestn Oftalmol 121:21-5. 2005
    ..The procedure is more adaptable to the problems of eye surgery due to the absence of systemic action on the patient's body...
  9. ncbi [Synthesis of triads based on deuteroporphyrin IX, naphthoquinone, and aromatic amino acids]
    E A Larkina
    Lomonosov State Academy of Fine Chemical Technology, pr Vernadskogo 86, Moscow, 117571 Russia
    Bioorg Khim 28:357-61. 2002
    ..The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 4; see also http://www.maik.ru...
  10. pmc NO orientation and tilting in (nitrosyl)iron(II) deuteroporphyrin IX
    Graeme R A Wyllie
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Inorg Chem 42:4259-61. 2003
    ..Off-axis tilting, a property associated with ordered (nitrosyl)iron(II) porphyrinates, is also investigated...
  11. ncbi Inactivation of gram-negative bacteria by photosensitized porphyrins
    Y Nitzan
    Department of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Photochem Photobiol 55:89-96. 1992
    ..aeruginosa was 5.2 x 10(-4). Electron microscopy depicted ultrastructural alterations in the Gram-negative cells treated by DP and PMNP. The completion of cell division was inhibited and the chromosomal domain was altered markedly...
  12. ncbi Inhibition of endogenous carbon monoxide production induces transient retention losses in the day-old chick when trained using a single trial passive avoidance learning task
    M C Cutajar
    Department of Psychology, School of Psychology, Psychiatry and Psychological Medicine, Monash University 3800, Vic, Australia
    Neurobiol Learn Mem 83:243-50. 2005
    ..In addition, the transient retention losses observed following administration of ZnBG suggest that CO may be necessary for memory retrieval and not formation as previously thought...
  13. ncbi Role of heme-oxygenase pathway on vasopressin deficiency during endotoxemic shock-like conditions
    Viviana Moreto
    Departamento de Enfermagem Geral e Especializada, Escola de Enfermagem de Ribeirão Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Shock 26:472-6. 2006
    ..These data suggest that central HO pathway may activate a control mechanism that attenuates AVP secretion during endotoxemia and may consequently regulate the MAP and diuretic output...
  14. ncbi Separation of peptides by open-tubular capillary electrochromatography using Fe(III)-deuteroporphyrin as a covalently attached stationary phase
    Angel Yone
    Department of Analytical Chemistry and Physicochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Ciudad de Buenos Aires, Argentina
    Electrophoresis 30:2293-9. 2009
    ..The iron (III)-deuteroporphyrin column proved to be highly stable over time and showed acceptable precision of migration times and corrected peak areas (RSD in the range 2-4%)...
  15. ncbi Redox and electrocatalytic properties of mimochrome VI, a synthetic heme peptide adsorbed on gold
    Antonio Ranieri
    Department of Chemistry, University of Modena and Reggio Emilia, Via Campi 183, 41125 Modena, Italy
    Langmuir 26:17831-5. 2010
    ..This work sets the premise for the exploitation of totally synthetic mimochrome-modified electrode surfaces for clinical and pharmaceutical biosensing...
  16. ncbi Study of peptide-ligand interactions in open-tubular capillary columns covalently modified with porphyrins
    Angel Yone
    Department of Analytical Chemistry and Physicochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Ciudad de Buenos Aires, Argentina
    Electrophoresis 32:2840-7. 2011
    ..The results showed that differences in metal core on the porphyrin and the spatial conformation of attached porphyrin result in changes in the analyte interaction with the stationary phase...
  17. ncbi Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis
    Paula Giselle Czaikoski
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Shock 39:389-96. 2013
    ..These results show that heme oxygenase is involved in the pathophysiology of pneumonia-induced sepsis and suggest that HO inhibitors could be helpful for the management of this disease...
  18. ncbi Photodynamic effect of deuteroporphyrin IX and hematoporphyrin derivatives on single neuron
    A B Uzdensky
    Rostov State University, Rostov-on-Don, 344090, Russia
    Biochem Biophys Res Commun 281:1194-9. 2001
    ..The most effective sensitizers were 4-(1-methyl-3-hydroxybutyl)- and 4-(1-methyl-2-acetyl-3-oxobutyl)-deuteroporphyrins. Extinction and amphiphilicity were shown to be the most important properties determining photodynamic ..
  19. ncbi In vitro uptake of dicarboxylic porphyrins by human atheroma. Kinetic and analytical studies
    E Delettre
    Laboratoire de Biophysique, INSERM U 201, CNRS U A 481, Museum national d histoire naturelle, Paris, France
    Photochem Photobiol 54:239-46. 1991
    ..Taking into account previous data on animal models (Photochem. Photobiol. (1989), 731-737), it appears however that, in vivo, interactions with proteins and pharmacokinetics will primarily determine plaque labelling...
  20. pmc Binding of porphyrin to human serum albumin. Structure-activity relationships
    S Cohen
    Department of Biochemistry, George S Wise Life Science Center, Tel Aviv University, Israel
    Biochem J 270:325-30. 1990
    ..On the basis of this study an evaluation of human serum albumin as an endogenous carrier for porphyrins (at various aggregation states) in photodynamic therapy of tumours is presented...
  21. ncbi Carbon monoxide is the heme oxygenase product with a pyretic action: evidence for a cGMP signaling pathway
    A A Steiner
    Departamento de Morfologia, Estomatologia e Fisiologia, , , , , Brazil
    Am J Physiol Regul Integr Comp Physiol 280:R448-57. 2001
    ..Because biliverdine and iron had no thermoregulatory effects and CO produces most of its actions via sGC, these data strongly imply that CO is the only HO product with a pyretic action in the CNS...
  22. ncbi Glutathione-dependent oxidative modification of protoporphyrin and other dicarboxylic porphyrins by mammalian and plant peroxidases
    N J Jacobs
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire, 03755, USA
    Biochem Biophys Res Commun 259:195-200. 1999
    ..Two related nonnatural dicarboxylic porphyrins, with ethyl or hydroxyethyl instead of vinyl side chains, are not substrates or products for this enzymatic conversion...
  23. ncbi Functional comparison of the myoglobins reconstituted with symmetric deuterohemes
    S Neya
    Department of Physical Chemistry, Kyoto Pharmaceutical University, Japan
    Biochim Biophys Acta 1296:245-9. 1996
    ..The results therefore suggest that the two asymmetric deuteroheme IX isomers, which are inverted about the alpha, gamma-meso carbon axis of the heme, also exhibit very similar functions in myoglobin...
  24. ncbi Contribution of zinc deficiency to insulin resistance in patients with primary biliary cirrhosis
    Takashi Himoto
    Department of Integrated Medicine, Kagawa University School of Medicine, 1750 1, Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Biol Trace Elem Res 144:133-42. 2011
    ....
  25. pmc Effects of zinc deuteroporphyrin bis glycol on newborn mice after heme loading
    Cynthia X He
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    Pediatr Res 70:467-72. 2011
    ..We conclude that ZnBG may be an attractive compound for treating severe neonatal hyperbilirubinemia caused by hemolytic disease...
  26. pmc The allosteric role of the AAA+ domain of ChlD protein from the magnesium chelatase of synechocystis species PCC 6803
    Nathan B P Adams
    From the Department of Chemistry, The University of Sheffield, Sheffield S3 7HF, United Kingdom
    J Biol Chem 288:28727-32. 2013
    ..Using a series of mutants in the AAA(+) domain of ChlD, we show that this site is essential for magnesium chelation and allosterically regulates Mg(2+) and MgATP(2-) binding. ..
  27. ncbi Role of the peripheral heme oxygenase-carbon monoxide pathway on the nociceptive response of rats to the formalin test: evidence for a cGMP signaling pathway
    Carlos G O Nascimento
    Department of Physiology, Medical School of Ribeirao Preto, and Dental School of Ribeirão Preto, University of Sao Paulo, Brazil
    Eur J Pharmacol 556:55-61. 2007
    ..These findings strongly indicate that CO is the HO pathway product that plays an antinociceptive role during the formalin test, acting via cGMP...
  28. ncbi A novel ex vivo skin model to study the susceptibility of the dermatophyte Trichophyton rubrum to photodynamic treatment in different growth phases
    Threes G M Smijs
    Leiden University Medical Centre, Skin Research Laboratory, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Antimicrob Chemother 59:433-40. 2007
    ..rubrum when using red light...
  29. ncbi Heme orientational disorder in human adult hemoglobin reconstituted with a ring fluorinated heme and its functional consequences
    Satoshi Nagao
    Department of Chemistry, University of Tsukuba, Tsukuba 305 8571, Japan
    Biochem Biophys Res Commun 354:681-5. 2007
    ..These results indicated that the heme orientational disorder could exert little effect, if any, on the O(2) affinity properties of Hb A. This finding provides new insights into structure-function relationship of Hb A...
  30. ncbi Autocatalytic formation of a covalent link between tryptophan 41 and the heme in ascorbate peroxidase
    Zoi Pipirou
    Department of Chemistry, University of Leicester, University Road, Leicester LE1 7RH, England
    Biochemistry 46:2174-80. 2007
    ..Collectively, the data suggest that radical formation at the distal tryptophan position is not an exclusive feature of the KatG enzymes and may be used more widely across other members of the class I heme peroxidase family...
  31. ncbi Autonomic cardiovascular responses to heme oxygenase inhibition in conscious rats
    Haruhisa Hirakawa
    Department of Physiology, National Defense Medical College, Saitama, Japan
    Hypertension 48:1124-9. 2006
    ..We conclude that the CO/HO system plays an important role in cardiovascular regulation by modulating sympathetic tone...
  32. pmc Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation
    A Freitas
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Br J Pharmacol 149:345-54. 2006
    ..Here, we address the role of HO and its metabolites, carbon monoxide (CO) and biliverdin (BVD), in leukocyte rolling, adhesion and neutrophil migration during inflammatory processes...
  33. ncbi Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury
    Mark R Duranski
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 291:H2980-6. 2006
    ..These results suggest that hepatic protection in eNOS-TG mice may be mediated in part by NO signaling via the sGC-cGMP pathway and is independent of HO-1 signal transduction pathways...
  34. ncbi Beyond gastric acid reduction: proton pump inhibitors induce heme oxygenase-1 in gastric and endothelial cells
    Jan C Becker
    Department of Medicine B, University of Muenster, 48149 Muenster, Germany
    Biochem Biophys Res Commun 345:1014-21. 2006
    ..Moreover, our findings provide additional perspectives for a possible but yet unexplored use of PPIs in vasoprotection...
  35. ncbi Systemic effects of orally-administered zinc and tin (IV) metalloporphyrins on heme oxygenase expression in mice
    Ichiro Morioka
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Pediatr Res 59:667-72. 2006
    ..We conclude that the three Mps are absorbed at different rates in the mouse and affect bilirubin production and HO-1 expression in a tissue- and time-dependent manner...
  36. ncbi Aggregation of two carboxylic derivatives of porphyrin and their affinity to bovine serum albumin
    Yao Bing Yin
    Key Laboratory of Functional Polymer Materials Ministry of Education, Nankai University, Tianjin 300071, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 64:1032-8. 2006
    ..The whole procedure of titration could be divided into three successive stages. The three-banded profiles of TA4C might be explained according to a loose dimer model...
  37. ncbi Fever induced by platelet-derived growth factor, in contrast to fever induced by lipopolysaccharide, depends only on nitric oxide, but not on carbon monoxide pathway
    Maria Camila Almeida
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    Eur J Pharmacol 467:133-40. 2003
    ..Our data indicate that the NO but not the CO pathway participates in PDGF-BB fever. Furthermore, our data show that nNOS is the NOS isoform responsible for NO synthesis in this response...
  38. ncbi Influence of the heme-oxygenase pathway on cerebrocortical blood flow
    Miriam Leszl-Ishiguro
    Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary
    Neuroreport 18:1193-7. 2007
    ..Our results indicate that endogenous CO reduces the resting CBF via inhibition of NOS but fails to influence the CBF response to hypoxia and hypercapnia in adult rats...
  39. ncbi Tetrapyrrole-photosensitizers vectorization and plasma LDL: a physico-chemical approach
    Stephanie Bonneau
    Universite Pierre et Marie Curie, Paris 6, UMR 7033, BioMoCeTi, Paris, F 75005, France
    Int J Pharm 344:78-87. 2007
    ..PCI has been shown to potentiate the biological activity of a large variety of macromolecules. The comprehension of the mechanisms governing this particular sub-cellular localization could allow the design of better candidates for PCI...
  40. ncbi Investigation of conditions involved in the susceptibility of the dermatophyte Trichophyton rubrum to photodynamic treatment
    Threes G M Smijs
    Leiden University Medical Centre, Leiden, The Netherlands
    J Antimicrob Chemother 60:750-9. 2007
    ....
  41. ncbi Iron(III) mesoporphyrin IX and iron(III) deuteroporphyrin IX bind to the Porphyromonas gingivalis HmuY hemophore
    Jacek Wojaczyński
    University of Wrocław, Department of Chemistry, F Joliot Curie 14 Street, 50 383 Wrocław, Poland
    Biochem Biophys Res Commun 411:299-304. 2011
    ..Since the use of porphyrins either as active photosensitizers or in combination with antibiotics may have therapeutic value for controlling bacterial growth in vivo, it is important to compare the binding of heme derivatives to HmuY...
  42. ncbi NMR study on the major components in hematoporphyrin derivative YHPD
    Y X Fu
    Institute of Biophysics, Academia Sinica, Beijing
    Sci China B 32:442-57. 1989
    ....
  43. ncbi First evaluation of the biologic effectiveness factors of boron neutron capture therapy (BNCT) in a human colon carcinoma cell line
    Maria Alejandra Dagrosa
    Department of Radiobiology, National Atomic Energy Commission, Buenos, Argentina
    Int J Radiat Oncol Biol Phys 79:262-8. 2011
    ....
  44. ncbi A facile synthesis of deuteroporphyrins derivatives under ultrasound irradiation
    Bingcheng Hu
    School of Chemical Engineering, Nanjing University of Science and Technology, Jiangsu Province, China
    Ultrason Sonochem 17:288-91. 2010
    ..The characterization of these compounds confirms the synthetic methodology. Compared with conventional methods, the main advantages of the present procedure are shorter reaction time and higher yields...
  45. pmc Bystander effects induced by diffusing mediators after photodynamic stress
    Asima Chakraborty
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Radiat Res 172:74-81. 2009
    ..Hence, when considering outcomes of photodynamic action in cells and tissue, bystander effects may be significant, especially at sublethal fluences...
  46. ncbi Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice
    Gabor Czibik
    Department of Physiology, IMB, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103, Blindern, NO 0317 Oslo, Norway
    Cardiovasc Res 82:107-14. 2009
    ..The present study investigates whether the cardioprotection achieved by gene delivery of hypoxia-inducible factor-1 alpha (HIF-1 alpha) depends on the downstream factor haem oxygenase (HMOX)-1...
  47. ncbi Carbon monoxide-prostaglandin E2 interaction in the hypothalamic circulation
    Bėla Horváth
    Institute of Human Physiology and Clinical Experimental Research, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Neuroreport 19:1601-4. 2008
    ..Therefore, constitutive carbon monoxide release seems to have two indirect effects on the hypothalamic circulation: vasodilation mediated by PGE2 and vasoconstriction as a result of NOS inhibition...
  48. ncbi Role of locus coeruleus heme oxygenase-carbon monoxide-cGMP pathway during hypothermic response to restraint
    Maria Ida Bonini Ravanelli
    Department of Physiology, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Brain Res Bull 75:526-32. 2008
    ..3 nmol). Taken together, these data suggest that CO in the LC produced by the HO pathway and acting via cGMP is implicated in thermal responses to restraint...
  49. ncbi Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells
    S T Magness
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7080, USA
    Hum Gene Ther 6:1285-90. 1995
    ..Therefore, the presence of the mutant ferrochelatase protein did not inhibit the ferrochelatase activity expressed by the transgene...
  50. ncbi Role of the spinal cord heme oxygenase-carbon monoxide-cGMP pathway in the nociceptive response of rats
    Carlos G O Nascimento
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Eur J Pharmacol 581:71-6. 2008
    ..These findings strongly indicate that the HO pathway plays a spinal antinociceptive role during the formalin test, acting via cGMP...
  51. ncbi Optimization of boron neutron capture therapy for the treatment of undifferentiated thyroid cancer
    Maria Alejandra Dagrosa
    Department of Radiobiology Constituyentes Atomic Center, National Atomic Energy Commission of Argentina, Buenos Aires, Argentina
    Int J Radiat Oncol Biol Phys 69:1059-66. 2007
    ....
  52. ncbi Boron neutron capture therapy in cancer: past, present and future
    Mario A Pisarev
    Division of Nuclear Biochemistry, Department of Radiobiology, National Atomic Energy Commission, Buenos Aires, Argentina
    Arq Bras Endocrinol Metabol 51:852-6. 2007
    ..Moreover dogs with spontaneous UTC also have a selective uptake of BPA. At the present we are studying the biodistribution of BPA in patients with UTC before its application in humans...
  53. pmc L-methionine reduces oxidant stress in endothelial cells: role of heme oxygenase-1, ferritin, and nitric oxide
    Kati Erdmann
    Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, 06099 Halle, Saale, Germany
    AAPS J 7:E195-200. 2005
    ..This novel, indirect antioxidant action might be relevant for the preventive potential of methionine and methionine rich diets under conditions of inflammation and oxidative stress...
  54. ncbi Toxicity, biodistribution, and convection-enhanced delivery of the boronated porphyrin BOPP in the 9L intracerebral rat glioma model
    Tomoko Ozawa
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 0446, USA
    Int J Radiat Oncol Biol Phys 63:247-52. 2005
    ..To investigate the toxicity, biodistribution, and convection-enhanced delivery (CED) of a boronated porphyrin (BOPP) that was designed for boron neutron capture therapy and photodynamic therapy...
  55. ncbi Comparison of protease-resistant prion protein inhibitors in cell cultures infected with two strains of mouse and sheep scrapie
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Neurosci Lett 388:106-11. 2005
    ..These results identify new inhibitors of murine and ovine PrP-res formation and reinforce the idea that compounds effective against PrP-res from one species or strain cannot be assumed to be active against others...
  56. ncbi Tumor versus vascular photodamage in a rat tumor model
    D Kessel
    Wayne State University, School of Medicine, Detroit, MI 48021, USA
    J Photochem Photobiol B 45:25-7. 1998
    ..FANFT cells are protected from direct cell kill mediated by this drug, suggesting that the substantial delay in tumor regrowth from this tumor/sensitizer combination can be attributed to vascular effects...
  57. ncbi [Photohemolysis sensitized by deuteroporphyrin-IX derivatives: determination of binding strength of dyes to erythrocytes]
    G V Mansurova
    Russian State Medical University, Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia
    Biofizika 48:251-5. 2003
    ..It was shown that the beta values for dyes I and II are 86 and 61% and correlate with the coefficients of distribution of the dyes in the octanol/water system (20.7 and 17.0, respectively)...
  58. pmc Porphyrin-mediated cell surface heme capture from hemoglobin by Porphyromonas gingivalis
    Mayuri Paramaesvaran
    Institute of Dental Research, Centre for Oral Health, Westmead Hospital, Wentworthville, Sydney NSW 2145, Australia
    J Bacteriol 185:2528-37. 2003
    ..While some proteins involved with heme capture bind directly to the iron center, the HA2 domain of P. gingivalis recognizes heme by a mechanism that is solely porphyrin mediated...
  59. ncbi GUN4, a regulator of chlorophyll synthesis and intracellular signaling
    Robert M Larkin
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 299:902-6. 2003
    ..GUN4 binds the product and substrate of Mg- chelatase, an enzyme that produces Mg-Proto, and activates Mg-chelatase. Thus, GUN4 participates in plastid-to-nucleus signaling by regulating Mg-Proto synthesis or trafficking...
  60. ncbi Porphyrin and phthalocyanine antiscrapie compounds
    S A Priola
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Science 287:1503-6. 2000
    ..The significant inhibition of TSE disease by structurally dissimilar tetrapyrroles identifies these compounds as anti-TSE drugs...
  61. ncbi Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect
    Wan Chen Lo
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan, ROC
    Eur J Pharmacol 454:39-45. 2002
    ..They also suggested that CO and excitatory amino acids may interact in the nucleus tractus solitarii of rats...
  62. ncbi Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1
    Weisheng Zhang
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University Medical Center, Stanford University, Stanford, CA 94305 5208, USA
    J Mol Med (Berl) 80:655-64. 2002
    ..Among the known inhibitors of HO enzyme activity that were evaluated in this study, ZnBG did not significantly affect HO-1 transcription and therefore may be well suited for the prevention of neonatal jaundice...
  63. ncbi Central heme oxygenase-carbon monoxide pathway in the control of breathing under normoxia and hypoxia
    Flavia M Paro
    Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirao Preto, Ribeirao Preto SP, Brazil
    Respir Physiol Neurobiol 130:151-60. 2002
    ..Conformably, i.c.v. heme-lysinate did not affect VE as well. These results do not support the hypothesis that the HO-CO pathway in the central nervous system is involved in hypoxia-induced hyperventilation...
  64. ncbi Influence of heme oxygenase inhibitors on the basal tissue enzymatic activity and smooth muscle relaxation of internal anal sphincter
    S Rattan
    Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Pharmacol Exp Ther 294:1009-16. 2000
    ..Suppression of basal HO activity and the IAS smooth muscle relaxation induced by NANC nerve stimulation or VIP but not NO suggest that some of the stimuli that cause IAS smooth muscle relaxation may involve HO activity...
  65. ncbi Heme oxygenase-1 modulates fetal growth in the rat
    Doron Kreiser
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94304, USA
    Lab Invest 82:687-92. 2002
    ..These observations demonstrate that HO-1 modulates fetal growth by its effects on placental growth factors...
  66. ncbi Role of the haem oxygenase-carbon monoxide pathway in insulin-induced hypothermia: evidence for carbon monoxide involvement
    Camila Almeida
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, 14049 900, Brasil
    Pflugers Arch 444:244-50. 2002
    ....
  67. ncbi Self-association of disulfonated deuteroporphyrin and its esters in aqueous solution and photosensitized production of singlet oxygen by the dimers
    Julien Dairou
    Laboratoires de Photobiologie et de Biophysique, CNRS UMR8646, INSERM U 201 Muséum National d Histoire Naturelle, Paris, France
    Photochem Photobiol 75:229-36. 2002
    ..and careful examination of the fluorescence excitation spectra show that the dimers of disulfonated deuteroporphyrins do not fluoresce at all...
  68. ncbi In vivo and in vitro photodynamic studies with benzochlorin iminium salts delivered by a lipid emulsion
    G M Garbo
    Division of Surgical Oncology, University of Louisville, KY 40202, USA
    Photochem Photobiol 68:561-8. 1998
    ..7 (mumole/kg and 200 J/cm2. These results indicate that iminium salts have characteristics that may make them promising third-generation photosensitizers...
  69. ncbi Chlorin-type photosensitizers photochemically derived from vinyl porphyrins
    D Brault
    Laboratoires de Photobiologie et de Biophysique, Museum national d histoire naturelle, 43 rue Cuvier, 75231 Paris Cedex 05, France
    Photochem Photobiol 73:331-8. 2001
    ..As exemplified with VD and EVD, they also point out the reaction of singlet oxygen as an efficient route to chlorin-type photosensitizers...
  70. ncbi Determination of the hemoglobin surface domains that react with cytochrome b5
    N R Naito
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Biochemistry 40:2060-5. 2001
    ..The charge-neutralization results further suggest that b(5) binds over a broad area of the subunit face, but reacts only in a minority population of binding geometries...
  71. ncbi Promising survival in patients with high-grade gliomas following therapy with a novel boronated porphyrin
    Mark A Rosenthal
    Centre for Developmental Cancer Therapeutics, Parkville, Victoria, Australia
    J Clin Neurosci 10:425-7. 2003
    ..Of 9 pts with recurrent GBM, the median OS was 11 months (3-38+), with 56% surviving at least 12 months. In conclusion, BOPP photodynamic therapy was associated with encouraging survival particularly in the recurrent GBM setting...
  72. ncbi Interaction of carbon monoxide and adenosine in the nucleus tractus solitarii of rats
    Chia Hui Lin
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Rd, Kaohsiung, Taiwan, ROC
    Hypertension 42:380-5. 2003
    ..These results indicate that the interaction between carbon monoxide and adenosine may contribute to the activation of heme oxygenase in central cardiovascular regulation...
  73. ncbi Role of endogenous carbon monoxide in central regulation of arterial pressure
    R A Johnson
    Department of Pharmacology, New York Medical College, Valhalla 10595, USA
    Hypertension 30:962-7. 1997
    ..Accordingly, the pressor effect of ZnDPBG may rely on inhibition of carbon monoxide production in the NTS. This implies that carbon monoxide formed by brain heme oxygenase plays a role in the central regulation of arterial pressure...
  74. ncbi Biodistribution of boron compounds in an animal model of human undifferentiated thyroid cancer for boron neutron capture therapy
    M Alejandra Dagrosa
    Departments of Radiobiology and Chemistry, National Atomic Energy Commission, Av del Libertador 8250, Buenos Aires 1429, Argentina
    Mol Pharm 2:151-6. 2005
    ..8. Other important ratios were tumor/thyroid approximately 6.6 and tumor/lung approximately 2.9. These results open the possibility of improving the efficacy of BNCT for the treatment of this so far "orphan" tumor...
  75. ncbi [Formylation of porphyrin platinum complexes]
    V D Rumiantseva
    Bioorg Khim 31:103-7. 2005
    ..The resulting formyl derivatives of the porphyrins are of interest for fluorescent immunoassay...
  76. ncbi The effect of pH on the topography of porphyrins in lipid membranes
    Irena Bronshtein
    Department of Physics, Bar Ilan University, Ramat Gan, Israel
    Photochem Photobiol 81:446-51. 2005
    ..This increases the dwell time of singlet oxygen within the bilayer, which results in greater photodamage to a membrane-residing singlet oxygen target...
  77. ncbi Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV
    Luigi Di Costanzo
    Centre of Excellence in Biocrystallography, Department of Chemical Science, University of Trieste, Via L Giorgieri 1, 34127, Trieste, Italy
    J Biol Inorg Chem 9:1017-27. 2004
    ..However, in the crystal structure, intrachain Glu1-Arg9 ion pairs are preferred over the designed, and experimentally found in solution, interchain interactions. This ion pairing switch may be related to strong packing interactions...
  78. ncbi Detecting bioactive amyloid beta peptide species in Alzheimer's disease
    Yuanbin Liu
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Neurochem 91:648-56. 2004
    ..A promising deuteroporphyrin that can inactivate bioactive A beta species was also identified using this assay. These novel insights and findings should have important implications for the treatment of AD...
  79. ncbi Dynamics of interactions of photosensitizers with lipoproteins and membrane-models: correlation with cellular incorporation and subcellular distribution
    Stephanie Bonneau
    Laboratoire de Physicochimie Biomoleculaire et Cellulaire, Universite Pierre et Marie Curie, CNRS UMR 7033, 75005 Paris, France
    Biochem Pharmacol 68:1443-52. 2004
    ..The dynamics of the interactions of photosensitizers with membranes appears as an important determinant of their subcellular localization...
  80. ncbi Horseradish peroxidase-dependent oxidation of deuteroporphyrin IX into chlorins
    F E Dayan
    USDA ARS NPURU, National Center for the Development of Natural Products, School of Pharmacy, University of Mississippi, 38677, USA
    Arch Biochem Biophys 351:27-34. 1998
    ..The ensuing steps, probably involving an oxygen free radical and porphyrin radical intermediates, consume a large amount of O2 to oxidize Deutero into chlorin...
  81. ncbi Photodynamic treatment of the dermatophyte Trichophyton rubrum and its microconidia with porphyrin photosensitizers
    Threes G M Smijs
    Department of Ophthamology, Leiden University Medical Centre, 2333 AL Leiden, The Netherlands
    Photochem Photobiol 80:197-202. 2004
    ..These results offer the ingredients for a future treatment of fungal infections, including those of the nail...
  82. ncbi Eradication of Acinetobacter baumannii by photosensitized agents in vitro
    Y Nitzan
    Department of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Photochem Photobiol B 42:211-8. 1998
    ..When the protein concentration is high photoinactivation efficiency depends on the type of protein present in the medium...
  83. pmc Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol
    L Atzori
    Centre for Respiratory Research, Royal Free and University College London Medical School, London, UK
    Thorax 59:217-23. 2004
    ..A study was undertaken to examine the effects of the HO inhibitor Zn-deuteroporphyrin-IX-2,4-bisethylene glycol (Zndtp) on the development of pulmonary fibrosis in the bleomycin model of lung injury and repair...
  84. ncbi Dynamics of pH-dependent self-association and membrane binding of a dicarboxylic porphyrin: a study with small unilamellar vesicles
    Stephanie Bonneau
    Laboratoire de Physicochimie Biomoleculaire et Cellulaire, CNRS UMR 7033, Universite Pierre et Marie Curie, 75005 Paris, France
    Biochim Biophys Acta 1661:87-96. 2004
    ..They also indicate that the propensity of these molecules to self-associate at low pH could yield to some retention in acidic intracellular vesicles of the endosome/lysosome compartment...
  85. ncbi Cardiovascular and respiratory responses to heme oxygenase inhibition in conscious rats
    Haruhisa Hirakawa
    Department of Systems Physiology, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka, Japan
    Adv Exp Med Biol 536:455-60. 2003
  86. ncbi Different effects of constitutive nitric oxide synthase and heme oxygenase on pulmonary or liver metastasis of colon cancer in mice
    Takeshi Ishikawa
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Clin Exp Metastasis 20:445-50. 2003
    ..These results suggest that the activities of NOS and HO could influence experimental metastasis in an organ-specific manner...
  87. ncbi A photobiological and photophysical-based study of phototoxicity of two chlorins
    B W Pogue
    Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston 02114, USA
    Cancer Res 61:717-24. 2001
    ..The study points to the importance of combining photosensitizer uptake and localization with photophysical measurements in the relevant biological milieu to reasonably interpret and/or predict photosensitization efficacies...
  88. pmc Selective tumor kill of cerebral glioma by photodynamic therapy using a boronated porphyrin photosensitizer
    J S Hill
    Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia
    Proc Natl Acad Sci U S A 92:12126-30. 1995
    ..The data show that BOPP is more dose effective in vivo by a factor of 10 than the current clinically used photosensitizer hematoporphyrin derivative and suggest that BOPP may have potential as a dual PDT/BNCT sensitizer...
  89. ncbi Effect of porphyrins on the hematopoietic recovery of mice treated with gamma-radiation
    D W Hunt
    Department of Microbiology, University of British Columbia, Vancouver, Canada
    Immunopharmacol Immunotoxicol 16:55-70. 1994
    ....

Research Grants2

  1. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  2. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..