genetic markers


Summary: A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.

Top Publications

  1. ncbi Principal components analysis corrects for stratification in genome-wide association studies
    Alkes L Price
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:904-9. 2006
  2. pmc Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumann Strasse 21 22, 10117 Berlin, Germany
    Genetics 164:1567-87. 2003
  3. pmc Prediction of total genetic value using genome-wide dense marker maps
    T H Meuwissen
    Research Institute of Animal Science and Health, 8200 AB Lelystad, The Netherlands
    Genetics 157:1819-29. 2001
  4. pmc Rapid SNP discovery and genetic mapping using sequenced RAD markers
    Nathan A Baird
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, United States of America
    PLoS ONE 3:e3376. 2008
  5. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
  6. ncbi Genome-wide genetic marker discovery and genotyping using next-generation sequencing
    John W Davey
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    Nat Rev Genet 12:499-510. 2011
  7. pmc Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering
    Sharon R Browning
    Department of Statistics, The University of Auckland, Auckland, New Zealand
    Am J Hum Genet 81:1084-97. 2007
  8. pmc Population structure and eigenanalysis
    Nick Patterson
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
    PLoS Genet 2:e190. 2006
  9. ncbi PowerMarker: an integrated analysis environment for genetic marker analysis
    Kejun Liu
    Bioinformatics Research Center, North Carolina State University Raleigh, 27695 7566, USA
    Bioinformatics 21:2128-9. 2005
  10. ncbi adegenet: a R package for the multivariate analysis of genetic markers
    Thibaut Jombart
    Universite de Lyon, Universite Lyon 1, CNRS, UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, France
    Bioinformatics 24:1403-5. 2008

Detail Information

Publications354 found, 100 shown here

  1. ncbi Principal components analysis corrects for stratification in genome-wide association studies
    Alkes L Price
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:904-9. 2006
    ..Our simple, efficient approach can easily be applied to disease studies with hundreds of thousands of markers...
  2. pmc Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Schumann Strasse 21 22, 10117 Berlin, Germany
    Genetics 164:1567-87. 2003
    ..The methods are implemented in a program, structure, version 2.0, which is available at
  3. pmc Prediction of total genetic value using genome-wide dense marker maps
    T H Meuwissen
    Research Institute of Animal Science and Health, 8200 AB Lelystad, The Netherlands
    Genetics 157:1819-29. 2001
    ..It was concluded that selection on genetic values predicted from markers could substantially increase the rate of genetic gain in animals and plants, especially if combined with reproductive techniques to shorten the generation interval...
  4. pmc Rapid SNP discovery and genetic mapping using sequenced RAD markers
    Nathan A Baird
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, United States of America
    PLoS ONE 3:e3376. 2008
    ..Sequencing of RAD markers is an integrated platform for SNP discovery and genotyping. This approach should be widely applicable to genetic mapping in a variety of organisms...
  5. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
  6. ncbi Genome-wide genetic marker discovery and genotyping using next-generation sequencing
    John W Davey
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    Nat Rev Genet 12:499-510. 2011
    ..These new sequencing tools are also valuable for the discovery, validation and assessment of genetic markers in populations...
  7. pmc Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering
    Sharon R Browning
    Department of Statistics, The University of Auckland, Auckland, New Zealand
    Am J Hum Genet 81:1084-97. 2007 terms of both speed and accuracy for large data sets with thousands of individuals and densely spaced genetic markers, and we use our method to phase a real data set of 3,002 individuals genotyped for 490,032 markers in 3...
  8. pmc Population structure and eigenanalysis
    Nick Patterson
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
    PLoS Genet 2:e190. 2006
    ..This means that we can predict the dataset size needed to detect structure...
  9. ncbi PowerMarker: an integrated analysis environment for genetic marker analysis
    Kejun Liu
    Bioinformatics Research Center, North Carolina State University Raleigh, 27695 7566, USA
    Bioinformatics 21:2128-9. 2005
    ..It accelerates the analysis lifecycle and enables users to maintain data integrity throughout the process. An ever-growing list of more than 50 different statistical analyses for genetic markers has been implemented in PowerMarker.
  10. ncbi adegenet: a R package for the multivariate analysis of genetic markers
    Thibaut Jombart
    Universite de Lyon, Universite Lyon 1, CNRS, UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, France
    Bioinformatics 24:1403-5. 2008
    The package adegenet for the R software is dedicated to the multivariate analysis of genetic markers. It extends the ade4 package of multivariate methods by implementing formal classes and functions to manipulate and analyse genetic ..
  11. ncbi Exploiting EST databases for the development and characterization of gene-derived SSR-markers in barley (Hordeum vulgare L.)
    T Thiel
    Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, D 06466 Gatersleben, Germany
    Theor Appl Genet 106:411-22. 2003
  12. ncbi Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
    S Purcell
    Social, Genetics and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, De Crespigny Park, UK
    Bioinformatics 19:149-50. 2003
    ..A website for performing power calculations for the design of linkage and association genetic mapping studies of complex traits...
  13. pmc Transcriptome sequencing in an ecologically important tree species: assembly, annotation, and marker discovery
    Thomas L Parchman
    Department of Botany, University of Wyoming, Laramie, WY 82071, USA
    BMC Genomics 11:180. 2010
    ..Here we describe a sequencing study of expressed genes from P. contorta, including their assembly and annotation, and their potential for molecular marker development to support population and association genetic studies...
  14. ncbi A new multipoint method for genome-wide association studies by imputation of genotypes
    Jonathan Marchini
    Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK
    Nat Genet 39:906-13. 2007
    ..A notable future use of our method will be to boost power by combining data from genome-wide scans that use different SNP sets...
  15. ncbi Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice
    Weiya Xue
    National Key Laboratory of Crop Genetic Improvement, National Centre of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Nat Genet 40:761-7. 2008
    ..Natural mutants with reduced function enable rice to be cultivated in temperate and cooler regions. Thus, Ghd7 has played crucial roles for increasing productivity and adaptability of rice globally...
  16. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
    ..This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies...
  17. pmc New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree
    Tatiana M Karafet
    ARL Division of Biotechnology, University of Arizona, Tucson, Arizona 85721, USA
    Genome Res 18:830-8. 2008
    ..Several changes in the tree topology have important implications for studies of human ancestry. We also present demography-independent age estimates for 11 of the major clades in the new Y chromosome tree...
  18. pmc Choosing and using a plant DNA barcode
    Peter M Hollingsworth
    Genetics and Conservation Section, Royal Botanic Garden Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e19254. 2011
  19. pmc Computational and experimental analysis of microsatellites in rice (Oryza sativa L.): frequency, length variation, transposon associations, and genetic marker potential
    S Temnykh
    Department of Plant Breeding, USDA-ARS Center for Agricultural Bioinformatics, Cornell University, Ithaca, New York 14853-1901, USA
    Genome Res 11:1441-52. 2001
    ..This contribution brings the number of microsatellite markers that have been rigorously evaluated for amplification, map position, and allelic diversity in Oryza spp. to a total of 500...
  20. pmc The impact of genetic relationship information on genome-assisted breeding values
    D Habier
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    Genetics 177:2389-97. 2007
    ..The method of choice was Bayes-B; FR-LS should be investigated further, whereas RR-BLUP cannot be recommended...
  21. ncbi Microsatellites: genomic distribution, putative functions and mutational mechanisms: a review
    You Chun Li
    Institute of Evolution, University of Haifa, Haifa 31905, Israel
    Mol Ecol 11:2453-65. 2002
    ..This review also discusses the role of two putative mutational mechanisms, replication slippage and recombination, and their interaction in SSR variation...
  22. pmc Development and evaluation of a 9K SNP array for peach by internationally coordinated SNP detection and validation in breeding germplasm
    Ignazio Verde
    CRA Fruit Tree Research Center, Rome, Italy
    PLoS ONE 7:e35668. 2012
    ..Batsch] and related Prunus species, only a limited number of genetic markers, including simple sequence repeats (SSRs), have been available to date...
  23. pmc Linkage mapping and comparative genomics using next-generation RAD sequencing of a non-model organism
    Simon W Baxter
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e19315. 2011
    ..mori chromosomes shows for the first time, genetic synteny appears common beyond the Macrolepidoptera. RAD sequencing is a powerful system capable of rapidly generating chromosome specific data for non-model organisms...
  24. pmc Identification of several small main-effect QTLs and a large number of epistatic QTLs for drought tolerance related traits in groundnut (Arachis hypogaea L.)
    K Ravi
    International Crops Research Institute for the Semi Arid Tropics, Patancheru, India
    Theor Appl Genet 122:1119-32. 2011
    ..This study suggests deployment of modern approaches like marker-assisted recurrent selection or genomic selection instead of marker-assisted backcrossing approach for breeding for drought tolerance in groundnut...
  25. ncbi Identifying adaptive genetic divergence among populations from genome scans
    Mark A Beaumont
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK
    Mol Ecol 13:969-80. 2004 genomic surveys has become an area of intense research, stimulated by the increasing ease with which genetic markers can be typed...
  26. ncbi A high-density microsatellite consensus map for bread wheat (Triticum aestivum L.)
    Daryl J Somers
    Agriculture and Agri Food Canada, Cereal Research Centre, 195 Dafoe Rd, Winnipeg, MB, Canada, R3T 2 M9
    Theor Appl Genet 109:1105-14. 2004
    ..This enables users to predict allele sizes in new breeding populations and develop molecular breeding and genomics strategies...
  27. pmc Development and implementation of high-throughput SNP genotyping in barley
    Timothy J Close
    Department of Botany and Plant Sciences, University of California UCR, Riverside, CA, 92521, USA
    BMC Genomics 10:582. 2009
  28. pmc Association mapping of kernel size and milling quality in wheat (Triticum aestivum L.) cultivars
    Flavio Breseghello
    Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 172:1165-77. 2006
    ..Our results demonstrated that association mapping could complement and enhance previous QTL information for marker-assisted selection...
  29. ncbi A molecular marker for chloroquine-resistant falciparum malaria
    A Djimde
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    N Engl J Med 344:257-63. 2001
    ..Chloroquine resistance has been associated in vitro with point mutations in two genes, pfcrt and pfmdr 1, which encode the P. falciparum digestive-vacuole transmembrane proteins PfCRT and Pgh1, respectively...
  30. ncbi Mitochondrial DNA as a marker of molecular diversity: a reappraisal
    N Galtier
    Institut des Sciences de l Evolution, Universite Montpellier 2, C N R S UMR 5554, Place E Bataillon, CC 64, 34195 Montpellier, France
    Mol Ecol 18:4541-50. 2009
    ..We critically evaluate the usage of mitochondrial DNA for species delineation and identification. Finally, we note the great potential of accumulating mtDNA data for evolutionary and functional analysis of the mitochondrial genome...
  31. pmc Genetic design and statistical power of nested association mapping in maize
    Jianming Yu
    Institute for Genomic Diversity, Cornell University, Ithaca, New York 14853 2703, USA
    Genetics 178:539-51. 2008
    ..By integrating genetic design, natural diversity, and genomics technologies, this new complex trait dissection strategy should greatly facilitate endeavors to link molecular variation with phenotypic variation for various complex traits...
  32. pmc Rapid and cost-effective polymorphism identification and genotyping using restriction site associated DNA (RAD) markers
    Michael R Miller
    Institute for Molecular Biology, University of Oregon, Eugene, Oregon 97403, USA
    Genome Res 17:240-8. 2007
    ..large numbers of DNA sequence polymorphisms that disrupt restriction sites, which allows RAD tags to serve as genetic markers spread at a high density throughout the genome...
  33. ncbi Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers
    Rajeev K Varshney
    International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, India
    Nat Biotechnol 30:83-9. 2012
  34. ncbi Map Manager QTX, cross-platform software for genetic mapping
    K F Manly
    Cellular and Molecular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mamm Genome 12:930-2. 2001
    ..which allow it to be compiled for multiple computer platforms. It currently is distributed for Microsoft Windows and Mac OS and is available at
  35. pmc Prediction of genetic values of quantitative traits in plant breeding using pedigree and molecular markers
    Jose Crossa
    School of Land Crop and Food Sciences, University of Queensland, 4072, Sta Lucia, Queensland, Australia
    Genetics 186:713-24. 2010
    ..These results indicate that GS in plant breeding can be an effective strategy for selecting among lines whose phenotypes have yet to be observed...
  36. ncbi Genomic selection: prediction of accuracy and maximisation of long term response
    Mike Goddard
    Department of Primary Industries, University of Melbourne, Victoria, Australia
    Genetica 136:245-57. 2009
    ..This index varies the weight given to a marker according to its frequency such that markers where the favourable allele has low frequency receive more weight in the index...
  37. ncbi Efficiency and power in genetic association studies
    Paul I W de Bakker
    Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, Massachusetts 02114 2790, USA
    Nat Genet 37:1217-23. 2005
    ..Power is robust to the completeness of the reference panel from which tags are selected. These findings have implications for prioritizing tag SNPs and interpreting association studies...
  38. ncbi Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition
    Bernard Grisart
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
    Genome Res 12:222-31. 2002
  39. ncbi SNP marker diversity in common bean (Phaseolus vulgaris L.)
    Andrés J Cortés
    Centro Internacional de Agricultura Tropical CIAT, Apartado Aereo 6713, Cali, Colombia
    Theor Appl Genet 123:827-45. 2011
    ..Finally, we discuss that the ideal genetic marker combination with which to carry out diversity, mapping and association studies in common bean should consider a mix of both SNP and SSR markers...
  40. pmc A high-density SNP-based linkage map of the chicken genome reveals sequence features correlated with recombination rate
    Martien A M Groenen
    Animal Breeding and Genomics Centre, Wageningen University, 6700 AH Wageningen, The Netherlands
    Genome Res 19:510-9. 2009
    ..4-fold higher density at recombination hot spots versus cold spots, suggesting a functional relationship between recombination frequency and cohesin binding...
  41. ncbi Mapping with RAD (restriction-site associated DNA) markers to rapidly identify QTL for stem rust resistance in Lolium perenne
    W F Pfender
    Department of Botany and Plant Pathology, USDA ARS Forage Seed and Cereal Research Unit, Oregon State University, 3450 SW Campus Way, Corvallis, OR 97331, USA
    Theor Appl Genet 122:1467-80. 2011
    ..RAD markers facilitated rapid construction of new genetic maps in this outcrossing species and will enable development of sequence-based markers linked to stem rust resistance in L. perenne...
  42. ncbi Array-based high-throughput DNA markers for crop improvement
    P K Gupta
    Molecular Biology Laboratory, Department of Genetics and Plant Breeding, Ch Charan Singh University, Meerut, Uttar Pradesh, India
    Heredity (Edinb) 101:5-18. 2008
  43. pmc A second-generation combined linkage physical map of the human genome
    Tara C Matise
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    Genome Res 17:1783-6. 2007
    ..With nearly twice as many markers as our first-generation map, the Rutgers Map continues to be a unique and comprehensive resource for obtaining genetic map information for large sets of polymorphic markers...
  44. pmc Estimation of pairwise relatedness with molecular markers
    M Lynch
    Department of Biology, University of Oregon, Eugene, Oregon 97403
    Genetics 152:1753-66. 1999
    ..Two examples are given in which the new estimators are applied to natural populations, one that reveals isolation-by-distance in an annual plant and the other that suggests a genetic basis for a coat color polymorphism in bears...
  45. pmc Predicting quantitative traits with regression models for dense molecular markers and pedigree
    Gustavo de Los Campos
    Department of Animal Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 182:375-85. 2009
    ..Results indicate that inclusion of markers in the regression further improved the predictive ability of models. An R program that implements the proposed model is freely available...
  46. pmc Construction of a 10,000-marker ultradense genetic recombination map of potato: providing a framework for accelerated gene isolation and a genomewide physical map
    Hans van Os
    Laboratory of Plant Breeding, Wageningen University, The Netherlands
    Genetics 173:1075-87. 2006
  47. pmc Diversity Arrays Technology (DArT) for whole-genome profiling of barley
    Peter Wenzl
    Center for the Application of Molecular Biology to International Agriculture, G P O Box 3200, Canberra, ACT 2601, Australia
    Proc Natl Acad Sci U S A 101:9915-20. 2004
    ..These results highlight the potential of DArT as a generic technique for genome profiling in the context of molecular breeding and genomics...
  48. pmc Multiplexed shotgun genotyping for rapid and efficient genetic mapping
    Peter Andolfatto
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Genome Res 21:610-7. 2011
    ..Our analysis suggests that higher levels of multiplexing and/or use of strains with lower levels of divergence are practicable...
  49. ncbi Rapidly developing functional genomics in ecological model systems via 454 transcriptome sequencing
    Christopher W Wheat
    Metapopulation Research Group, Department of Biological and Environmental Sciences, University of Helsinki, P O Box 65, Viikinkaari 1, Helsinki 00014, Finland
    Genetica 138:433-51. 2010
    ..How to use species with genomic resources to inform study of those without is also discussed. In closing, some of the drawbacks of 454 sequencing are presented along with future prospects of this technology...
  50. pmc Genome-wide distribution and organization of microsatellites in plants: an insight into marker development in Brachypodium
    Humira Sonah
    National Research Centre on Plant Biotechnology, Indian Agricultural Research Institute IARI, New Delhi, India
    PLoS ONE 6:e21298. 2011
    ..SSR markers developed in this study would be helpful for genomic studies in Brachypodium and related grass species, especially for the map based cloning of the candidate gene(s)...
  51. pmc Transcriptome sequencing of lentil based on second-generation technology permits large-scale unigene assembly and SSR marker discovery
    Sukhjiwan Kaur
    Department of Primary Industries, Biosciences Research Division, Victorian AgriBiosciences Centre, La Trobe University Research and Development Park, Bundoora, Australia
    BMC Genomics 12:265. 2011
    ..There is hence a significant need to enhance such resources in order to identify novel genes and alleles for molecular breeding to increase crop productivity and quality...
  52. pmc Development of genic-SSR markers by deep transcriptome sequencing in pigeonpea [Cajanus cajan (L.) Millspaugh]
    Sutapa Dutta
    National Research Centre on Plant Biotechnology, Indian Agricultural Research Institute, New Delhi 110 012, India
    BMC Plant Biol 11:17. 2011
    ..We report a comprehensive set of validated genic simple sequence repeat (SSR) markers using deep transcriptome sequencing, and its application in genetic diversity analysis and mapping...
  53. pmc Comparative mapping of Brassica juncea and Arabidopsis thaliana using Intron Polymorphism (IP) markers: homoeologous relationships, diversification and evolution of the A, B and C Brassica genomes
    Priya Panjabi
    Centre for Genetic Manipulation of Crop Plants, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India
    BMC Genomics 9:113. 2008
    ..thaliana and analyzed the arrangement of 24 (previously described) genomic block segments in the A, B and C Brassica genomes to study the evolutionary events contributing to karyotype variations in the three diploid Brassica genomes...
  54. ncbi Statistical analysis of amplified fragment length polymorphism data: a toolbox for molecular ecologists and evolutionists
    A Bonin
    Diversity Arrays Technology P L, Yarralumla, ACT 2600, Australia
    Mol Ecol 16:3737-58. 2007
  55. pmc Complete switchgrass genetic maps reveal subgenome collinearity, preferential pairing and multilocus interactions
    Miki Okada
    US Department of Agriculture Agricultural Research Service, Genomics and Gene Discovery Research Unit, Western Regional Research Center, Albany, California 94710, USA
    Genetics 185:745-60. 2010
    ..The proportion of transmission ratio distorted markers was relatively low, but the male map was more extensively affected by distorted transmission ratios and multilocus interactions, associated with spurious linkages...
  56. ncbi Combining population genomics and quantitative genetics: finding the genes underlying ecologically important traits
    J R Stinchcombe
    Department of Ecology and Evolutionary Biology, Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario, Canada
    Heredity (Edinb) 100:158-70. 2008
    ..Such approaches are appealing because of (1) the increasing ease of generating large numbers of genetic markers, (2) the ability to scan the genome without measuring phenotypes and (3) the simplicity of sampling ..
  57. pmc Genomic selection using low-density marker panels
    D Habier
    Institute of Animal Breeding and Husbandry, Christian Albrechts University of Kiel, Kiel, Germany
    Genetics 182:343-53. 2009
  58. ncbi Development and mapping of 2240 new SSR markers for rice (Oryza sativa L.)
    Susan R McCouch
    Plant Breeding Dept, Cornell University, Ithaca, NY 14853 1901, USA
    DNA Res 9:199-207. 2002
    ..In combination with the pool of 500 previously mapped SSR markers, this release makes available a total of 2740 experimentally confirmed SSR markers for rice, or approximately one SSR every 157 kb...
  59. pmc A genetic map in the Mimulus guttatus species complex reveals transmission ratio distortion due to heterospecific interactions
    L Fishman
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Genetics 159:1701-16. 2001
    ..We discuss possible causes of the unequal representation of parental genomes in the F(2) generation...
  60. ncbi Ultraconserved elements anchor thousands of genetic markers spanning multiple evolutionary timescales
    Brant C Faircloth
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA
    Syst Biol 61:717-26. 2012
    ..Because many organismal lineages have UCEs, this type of genetic marker and the analytical framework we outline can be applied across the tree of life, potentially reshaping our understanding of phylogeny at many taxonomic levels...
  61. ncbi Genomic selection
    M E Goddard
    University of Melbourne, Attwood, Australia
    J Anim Breed Genet 124:323-30. 2007
    Genomic selection is a form of marker-assisted selection in which genetic markers covering the whole genome are used so that all quantitative trait loci (QTL) are in linkage disequilibrium with at least one marker...
  62. ncbi Comparison of a high-density genetic linkage map to genome features in the model grass Brachypodium distachyon
    Naxin Huo
    USDA ARS Western Regional Research Center, Albany, CA, 94710, USA
    Theor Appl Genet 123:455-64. 2011
    ..A comparison of adjacent genome regions with high versus low recombination rates revealed a positive correlation between interspecific synteny and recombination rate...
  63. ncbi Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    Desmond Padhi
    Amgen Inc, Thousand Oaks, CA, USA
    J Bone Miner Res 26:19-26. 2011
  64. ncbi A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    J N Feder
    Mercator Genetics, Inc, Menlo Park, California 94025, USA
    Nat Genet 13:399-408. 1996
    ..A role of this gene in haemochromatosis is supported by the frequency and nature of the major mutation and prior studies implicating MHC class I-like proteins in iron metabolism...
  65. pmc Genetic characterization and linkage disequilibrium estimation of a global maize collection using SNP markers
    Jianbing Yan
    Genetic Resources Program, International Maize and Wheat Improvement Center, Mexico City, Mexico
    PLoS ONE 4:e8451. 2009
    ..A core set of inbreds was defined based on haplotypes, and 60 lines capture 90% of the haplotype diversity of the entire panel. The defined core sets and the entire collection can be used widely for different research targets...
  66. pmc A genome-wide microsatellite polymorphism database for the indica and japonica rice
    Zhonghua Zhang
    James D Watson Institute of Genome Science, Zhejiang University, Hangzhou 310008, China
    DNA Res 14:37-45. 2007
    ..indica and japonica, composed of ample Class II MS markers, and integrated 18 828 MS loci from IRGSP and genetic markers from RGP. Based on genetic marker positions on the rice genome (
  67. ncbi Estimating population structure in diploids with multilocus dominant DNA markers
    L A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Mol Ecol 8:907-13. 1999
    ..The influence of a prior distribution and departure from Hardy-Weinberg proportions on the estimates is also considered...
  68. pmc High-resolution mapping of meiotic crossovers and non-crossovers in yeast
    Eugenio Mancera
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 454:479-85. 2008
    ..In addition, because non-crossover hotspots create holes of reduced linkage within haplotype blocks, our results stress the need to incorporate non-crossovers into genetic linkage analysis...
  69. ncbi OneMap: software for genetic mapping in outcrossing species
    G R A Margarido
    Department of Genetics, Escola Superior de Agricultura Luiz de Queiroz, Universidade de Sao Paulo, Piracicaba, Sao Paulo, Brazil
    Hereditas 144:78-9. 2007
    ..The software is freely available at approximately aafgarci/OneMap/...
  70. pmc Additive genetic variability and the Bayesian alphabet
    Daniel Gianola
    Department of Animal Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 183:347-63. 2009
    ..Methods that can solve potential shortcomings of some of these Bayesian regression procedures are discussed briefly...
  71. pmc Deregressing estimated breeding values and weighting information for genomic regression analyses
    Dorian J Garrick
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 41:55. 2009
    ..The literature indicates that researchers are inconsistent in their approach to using EBV or deregressed data, and as to using the appropriate methods for weighting some data sources to account for heterogeneous variance...
  72. pmc Performance of genomic selection in mice
    Andrés Legarra
    INRA, UR 631, F 31326 Auzeville, France
    Genetics 180:611-8. 2008
    ..Use of genomewide genetic markers increased predictive ability up to 0.22 across families and up to 0.03 within families...
  73. pmc Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome
    James Cockram
    Brewing Research International, Surrey, United Kingdom
    Proc Natl Acad Sci U S A 107:21611-6. 2010
    ..The methodology described here is transferable to species with limited genomic resources, providing a paradigm for reducing the threshold of map-based cloning in unsequenced crops...
  74. ncbi A comprehensive evaluation of SNP genotype imputation
    Michael Nothnagel
    Institute of Medical Informatics and Statistics, Christian Albrechts University, Kiel, Germany
    Hum Genet 125:163-71. 2009
    ..We nevertheless recommend either MACH or BEAGLE for practical use because these two programs are more user-friendly and generally require less memory than IMPUTE...
  75. pmc High-density integrated linkage map based on SSR markers in soybean
    Tae Young Hwang
    National Agricultural Research Center for Hokkaido Region, Sapporo, Hokkaido 062 8555, Japan
    DNA Res 16:213-25. 2009
    ..8. Our high-density linkage map should facilitate ongoing and future genomic research such as analysis of quantitative trait loci and positional cloning in addition to marker-assisted selection in soybean breeding...
  76. pmc An integrated genetic and cytogenetic map of the cucumber genome
    Yi Ren
    Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Sino Dutch Joint Lab of Horticultural Genomics, Opening Lab of Genetic Improvement of Agricultural Crops of Ministry of Agriculture, Beijing, China
    PLoS ONE 4:e5795. 2009
    ..This map will facilitate whole genome sequencing, positional cloning, and molecular breeding in cucumber, and enable the integration of knowledge of gene and trait in cucurbits...
  77. ncbi Distribution and location of genetic effects for dairy traits
    J B Cole
    Animal Improvement Programs Laboratory, ARS, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 92:2931-46. 2009
    ..Results validate quantitative genetic assumptions that most traits are due to the contributions of a large number of genes of small additive effect, rather than support the finite locus model...
  78. ncbi The molecular ecologist's guide to expressed sequence tags
    Amy Bouck
    Department of Biology, Box 90338, Duke University, Durham, NC 27708, USA
    Mol Ecol 16:907-24. 2007
    ..With this in mind, we close our review by discussing aspects of EST resource development of particular relevance for molecular ecologists...
  79. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  80. ncbi Genetic diversity and multiple infections of Plasmodium vivax malaria in Western Thailand
    Liwang Cui
    Department of Entomology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Trop Med Hyg 68:613-9. 2003
    Using two polymorphic genetic markers, the merozoite surface protein-3alpha (MSP-3alpha) and the circumsporozoite protein (CSP), we investigated the population diversity of Plasmodium vivax in Mae Sod, Thailand from April 2000 through ..
  81. pmc Association analysis of historical bread wheat germplasm using additive genetic covariance of relatives and population structure
    Jose Crossa
    International Maize and Wheat Improvement Center CIMMYT, 06600 Mexico, DF, Mexico
    Genetics 177:1889-913. 2007
    Linkage disequilibrium can be used for identifying associations between traits of interest and genetic markers. This study used mapped diversity array technology (DArT) markers to find associations with resistance to stem rust, leaf rust,..
  82. pmc Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D
    Diane J Berry
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, United Kingdom
    PLoS ONE 7:e37465. 2012
  83. ncbi The genetic mosaic suggests a new role for hitchhiking in ecological speciation
    Sara Via
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Mol Ecol 17:4334-45. 2008
    ..However, in hybridizing species, the genomic regions that affect ecologically based reproductive isolation are difficult to distinguish from regions that have diverged for other reasons...
  84. ncbi Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    Xiaofeng Li
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, 06030, USA
    J Biol Chem 280:19883-7. 2005
  85. ncbi Web-based primer design for single nucleotide polymorphism analysis
    Michael M Neff
    Dept of Biology, Washington University, Campus Box 1137, St Louis, MO 63130 4899, USA
    Trends Genet 18:613-5. 2002
    ..Here we describe a web-based program, dCAPS Finder 2.0, that facilitates the design of mismatched PCR primers to create or remove a restriction endonuclease recognition site relative to the polymorphism being analyzed...
  86. ncbi Functional markers in plants
    Jeppe R Andersen
    Department of Plant Biology, Danish Institute of Agricultural Sciences, Research Center Flakkebjerg, 4200, Slagelse, Denmark
    Trends Plant Sci 8:554-60. 2003
    ..Functional markers are superior to random DNA markers such as RFLPs, SSRs and AFLPs owing to complete linkage with trait locus alleles. We outline the definition, development, application and prospects of functional markers...
  87. ncbi Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
  88. pmc The first set of EST resource for gene discovery and marker development in pigeonpea (Cajanus cajan L.)
    Nikku L Raju
    International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, Greater Hyderabad, Andhra Pradesh, India
    BMC Plant Biol 10:45. 2010
    ..With an objective of enhancing genomic resources in pigeonpea, this study reports generation and analysis of comprehensive resource of FW- and SMD- responsive expressed sequence tags (ESTs)...
  89. ncbi Encoded evidence: DNA in forensic analysis
    Mark A Jobling
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
    Nat Rev Genet 5:739-51. 2004
  90. pmc A high-resolution linkage map for comparative genome analysis and QTL fine mapping in Asian seabass, Lates calcarifer
    Chun Ming Wang
    Molecular Population Genetics Group, Temasek Life Sciences Laboratory, National University of Singapore, Singapore
    BMC Genomics 12:174. 2011
    ..Here, we report a high-resolution linkage map with 790 microsatellites and SNPs, comparative analysis of synteny, fine-mapping of QTL and the identification of potential candidate genes for growth traits...
  91. ncbi On multiple-testing correction in genome-wide association studies
    Valentina Moskvina
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff, UK f ac uk
    Genet Epidemiol 32:567-73. 2008
    ..As the calculation is based on pairwise correlations between markers, it can be performed at the stage of study design using public databases...
  92. pmc Scanning the genome for gene single nucleotide polymorphisms involved in adaptive population differentiation in white spruce
    Marie Claire Namroud
    Canada Research Chair in Forest and Environmental Genomics and Arborea, Forest Research Centre, Pavillon Charles Eugène Marchand, Universite Laval, Quebec, Quebec, CanadaP4
    Mol Ecol 17:3599-613. 2008
    ..270 and F(ST) = 0.006) were comparable to those obtained with other genetic markers. Of all genes, 5...
  93. pmc Multiple multilocus DNA barcodes from the plastid genome discriminate plant species equally well
    Aron J Fazekas
    Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
    PLoS ONE 3:e2802. 2008
  94. pmc BatchPrimer3: a high throughput web application for PCR and sequencing primer design
    Frank M You
    Department of Plant Sciences, University of California, CA 95616, USA
    BMC Bioinformatics 9:253. 2008
    ..simple sequence repeat - SSR) and single nucleotide polymorphism (SNP) markers are two types of important genetic markers useful in genetic mapping and genotyping...
  95. ncbi A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    Richard H Duerr
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Science 314:1461-3. 2006
    ..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease...
  96. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  97. pmc Integration of novel SSR and gene-based SNP marker loci in the chickpea genetic map and establishment of new anchor points with Medicago truncatula genome
    Spurthi N Nayak
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, 502324, Andhra Pradesh, India
    Theor Appl Genet 120:1415-41. 2010
    ..This same population has been the focus of previous studies, permitting integration of new and legacy genetic markers into a single genetic map...
  98. ncbi Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
    Kenneth E S Poole
    MRC Bone Research Group, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    FASEB J 19:1842-4. 2005
    ..In doing so, sclerostin may act as a key inhibitory signal governing skeletal microarchitecture...
  99. ncbi Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    Xiaodong Li
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California 91320 1799, USA
    J Bone Miner Res 23:860-9. 2008
    ..Based on these data, sclerostin has emerged as a key negative regulator of bone mass. We generated SOST knockout (KO) mice to gain a more detailed understanding of the effects of sclerostin deficiency on bone...
  100. pmc A Brassica rapa linkage map of EST-based SNP markers for identification of candidate genes controlling flowering time and leaf morphological traits
    Feng Li
    Laboratory of Plant Breeding and Genetics, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba, Sendai, Miyagi 981 8555, Japan
    DNA Res 16:311-23. 2009
    ..Analysis of nucleotide sequences and expression of these genes suggested possible involvement of these genes in leaf morphological traits...
  101. pmc A first generation BAC-based physical map of the rainbow trout genome
    Yniv Palti
    National Center for Cool and Cold Water Aquaculture, ARS USDA, Kearneysville, WV 25430, USA
    BMC Genomics 10:462. 2009
    ..This resource will also facilitate efforts to obtain and assemble a whole-genome reference sequence for this species...

Research Grants75

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..of cancer endpoints in order to evaluate important questions related to lifestyle, biochemical markers, genetic markers, and gene-environment interactions on cancer risk...
  3. Predictors of sleep-dependent Memory Consolidation in Obstructive Sleep Apnea
    Ina E Djonlagic; Fiscal Year: 2013
    ..Ultimately, this research has the opportunity to provide critical information that may in due course alter how sleep apnea is defined and thus provide a major impact on the care of sleep apnea patients. ..
  4. Familial and Birth Cohort Effects on the Aging Senses
    Karen J Cruickshanks; Fiscal Year: 2013
    ..factors with these sensory impairments and ocular disorders, generational differences in risk and identify genetic markers for hearing impairment...
    Kinga Szigeti; Fiscal Year: 2013
    ..We propose to identify genetic markers that modify disease onset of AD...
  6. Rapid, Highly Multiplexed and Sensitive Blood Test for Drug-resistant Bacteria
    ARMIN H REITMAIR; Fiscal Year: 2010
    ..Specific aims are: 1. Separate detection and quantification of eight genetic markers (species-specific for Staphylococcus aureus, S. epidermidis, Enterococcus faecalis, E...
    JOANN ELISABETH MANSON; Fiscal Year: 2012
    ..These promising biochemical and genetic markers may have implications for improving prevention strategies, enhancing treatment options, and generating ..
  8. Innate immunity in dermal fibrosis and systemic sclerosis
    ROBERT A LAFYATIS; Fiscal Year: 2013
    ..Finally, experiments in aim 3 will examine how genetic markers associated with SSc, IRF5 and stat4, influence dermal inflammation and fibrosis using the poly(I:C) pump ..
  9. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2013
    ..Collect and store white blood cells from every subject to test for genetic markers should the intervention be found effective;4...
  10. Genome Sequencer FLX Instrument
    ANNE VIRGINIA KANE; Fiscal Year: 2010
    ..Research on genetic markers of cardiac disease susceptibility, the association of G protein-coupled receptor variants with obesity, ..
  11. Genome Wide Admixture Scan for Multiple Myeloma in African Americans
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2013
    ..More specifically, we will examine 1,000,000 genetic markers in 2,072 African American multiple myeloma cases and 4,645 African American controls...
  12. Molecular epidemiology of drug resistance and population genetic structure of Pla
    Fangli Lu; Fiscal Year: 2013
    ..parasites, and have done some preliminary studies on malaria field isolates from Yunnan and Hainan using genetic markers, thus enabling us to study the molecular epidemiology of these important malaria parasites in this proposal...
  13. Zebrafish Genetics to Identify Genes Involved in Hematopoiesis
    DHVANIT INDRAVADAN SHAH; Fiscal Year: 2013
    ..We have identified closely linked (~0 cM) genetic markers flanking the unique sav locus...
  14. Genetics of risk of chemotherapy-induced cardiotoxicity in cancer survivors
    Peter Demant; Fiscal Year: 2013
    ..We will use a specialized mouse model to develop a large set of new genetic markers of ACT risk and investigate individual heterogeneity of ACT pathogenesis...
  15. Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial
    Anil Sapru; Fiscal Year: 2013
    ..We will also genotype for tag SNPs in the corresponding genes and test for association of the plasma and genetic markers with clinical outcomes...
    Jerome F Strauss; Fiscal Year: 2010
    ..will disclose genetic and epigenetic factors that contribute to PPROM including racial/ethnic disparity in preterm birth, allow the identification of women at risk of PPROM, and identify genetic markers predicting PPROM.
  17. Genome-wide and Linkage Study of Quantitative Emphysema Phenotypes
    Stephen S Rich; Fiscal Year: 2010
    ..The specific topic is #8, "Analysis of genetic markers related to risk factors and disease in relation to their genetic and environmental context and how these may ..
  18. Risk Factors for Ischemic Stroke in Women
    Kathryn M Rexrode; Fiscal Year: 2012
    ..These promising biochemical and genetic markers may have implications for improving prevention strategies, enhancing treatment options and generating ..
  19. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    EMELIA J contact BENJAMIN; Fiscal Year: 2010 create a model to predict the development of atrial fibrillation and to determine whether biological or genetic markers help to classify further the risk of atrial fibrillation beyond standard clinical factors...
  20. Genomewide Determinants Of Prognosis And Treatment Of Early-Onset Breast Cancer
    Habibul Ahsan; Fiscal Year: 2010
    ..e., survival, cancer recurrence). We plan to comprehensively test over 600,000 genetic markers for associations with prognosis using data on ~4,000 breast cancer patients who have been under observation ..
  21. Genetic analysis fo metabolic syndrome by admixture mapping in African Americans
    Ludmila Pawlikowska; Fiscal Year: 2012
    ..with ancestry-informative markers across large genomic segments and can be mapped using relatively few genetic markers, compared to genome-wide association studies...
  22. Control of Cardiac Lineage Commitment and Differentiation in Murine Development
    Ibrahim J Domian; Fiscal Year: 2013
    ..To investigate the role of miRNAs in controlling the development of these lineages, we have used distinct genetic markers to develop a two-color transgenic murine system...
  23. Biomarkers for Esophageal Cancer Progression and Prognosis
    Tony E Godfrey; Fiscal Year: 2012
    ..Thus, at the end of this study we will have identified, verified and validated novel genetic markers that could be used for diagnosis, staging and treatment of esophageal adenocarcinoma...
    William E Whitehead; Fiscal Year: 2012
    ..Identifying these different phenotypes of IBS and the genetic markers associated with them may help to identify new targets for drug development and may help us to individualize ..
  25. Genetic by Context Influence on Trajectories of Adolescent Health Risk Behaviors
    Vangie A Foshee; Fiscal Year: 2010
    ..This study proposes to test interactions between genetic markers from five carefully selected regions - the serotonin transporter gene (SLC6A4), the monoamine oxidase A gene (..
  26. Astroglial Cells in Perinatal Brain Injury
    Flora M Vaccarino; Fiscal Year: 2012
    ..Importantly, the regenerative processes investigated in this proposal could be mimicked in adult and aged individuals, in which unfortunately cortical neuron loss is not recovered. ..
  27. Impact of hepatocyte lineage life history dynamics on liver homeostasis in the ag
    Edward E Schmidt; Fiscal Year: 2013
    ..abstract_text> ..
  28. Patient-Oriented Research on Hepatitis in Special Populations
    Raymond T Chung; Fiscal Year: 2013
    ..clinical prediction models and disease management algorithms that incorporate fundamental discoveries such as genetic markers, will be an important focus for young clinical investigators in the next grant cycle, as will creation of ..
  29. Genetic Analysis of Airflow Obstruction After Stem Cell Transplantation
    Joan G Clark; Fiscal Year: 2013
    ..Finally, we will use the genetic data from Aim 1 to identify a highly informative panel of genetic markers that will be predictive of this well-characterized phenotype...
  30. System for DNA-Guided Optimization and Personalization of Statin Therapy
    GUALBERTO RUANO; Fiscal Year: 2013
    ..balance safety with efficacy when prescribing statins, our research group and others have established genetic markers that are valid candidates for a panel of safety and efficacy markers...
  31. The Role of Amygdala GABAergic Transmission in Fear and Anxiety
    Scott A Heldt; Fiscal Year: 2011
    ..Our findings showed that the acquisition of fear induced a down regulation of genetic markers related to decreased amygdala GABAergic function;whereas the acquisition of fear extinction produced an up ..
  32. CD24 Polymorphism and Acetaminophen Toxicity
    Pan Zheng; Fiscal Year: 2010
    ..This proposal responds to 04-GM-101*, personalized drug response and toxicity. ..
  33. Women's Health Study: Continued Follow-Up
    Julie E Buring; Fiscal Year: 2010
    ..and specific CVD outcomes that are based not only on traditional risk factors but also on novel plasma and genetic markers. Secondary aims are to develop similar prediction scores for health conditions that are major CVD risk ..
    KENNETH TERCYAK; Fiscal Year: 2011
    ..of patient and professional conversational styles and exchanges about genetic test results from a panel of 15 genetic markers for 8 health conditions (diabetes, osteoporosis, heart disease, hypercholesterolemia, high blood pressure, ..
  35. Genetic, Genomic, and Imaging Biomarkers in Degenerative Dementia
    Giovanni Coppola; Fiscal Year: 2010
    ..This would be a valuable tool for biomarker identification, improved patients classification, therapy evaluation, and to further our understanding of disease pathophysiology. ..
  36. Understanding the genetic risk underlying racial disparities in uterine fibroids
    Digna R Velez Edwards; Fiscal Year: 2013
    ..We propose to identify genetic markers for risk of fibroids through a genome-wide association study (GWAS) of African American and Caucasian ..
  37. The Meningioma Consortium: Genome-Wide Association Study
    Elizabeth B Claus; Fiscal Year: 2013
    ..ongoing case/control project, b) 1699 controls from Illumina iControlDB and c) 1121 controls from the Cancer Genetic Markers of Susceptibility (CGEMs) study, 2) Using 700 additional Caucasian meningioma subjects drawn from our ..
    Jan C Buckner; Fiscal Year: 2013
    ..We have identified the prognostic and predictive value of pharmacogenetic and tumor tissue genetic markers in patients with specific cancers, and have evaluated the validity of surrogate endpoints for carefully ..
  39. Admixture Mapping of Preterm Birth Genes
    Jerome F Strauss; Fiscal Year: 2013
    ..b>Genetic markers could be used to identify subjects prospectively who might benefit from early interventions...
  40. Targeting the Pial Collateral Circulation for Mitigation of Cerebral Ischemia
    James E Faber; Fiscal Year: 2013
    ..Identifying this major allele that when polymorphic impairs collateral formation may also provide a genetic marker for use in these same patient groups. ..
  41. Cellular and Genetic Origins of Astrocytes
    David H Rowitch; Fiscal Year: 2012
    ..The goal of the proposed research is to identify a set of genetic markers for development of astrocytes and to map their cellular origins in the central nervous system...
  42. Bisphenol A and Phthalate Exposure in Relation to Fetal Growth and Preterm Birth
    John D Meeker; Fiscal Year: 2013
    ..Finally, the study will provide data on the interaction of phthalates and BPA with genetic markers of interest in relation to fetal development and risk of preterm birth.
  43. Genetic Markers Associated with Epithelial Ovarian Cancer and Hypodontia
    Lorri A Morford; Fiscal Year: 2012
    Eric B Rimm; Fiscal Year: 2013
    ..We propose to assess blood and genetic markers of oxidation and identify participants at highest risk of incident coronary disease in an ongoing 22-year ..
  45. Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE Trial
    Inga Peter; Fiscal Year: 2012
    ..End of Abstract) ..
  46. MicroRNA Related Genetic Variation in Bladder Cancer Recurrence and Survival
    ..We propose to identify a new class of genetic markers of bladder cancer recurrence and survival that will contribute to the development of clinical decision-making ..
  47. A multiethnic comparative effectiveness study for diagnosis of cardiogenic stroke
    Jeffrey R Gulcher; Fiscal Year: 2011
    ..have supported the notion that there are many stroke patients with undiagnosed AF: these widely replicated genetic markers show significant correlation to both cryptogenic and large vessel strokes in several cohorts - suggesting ..
  48. Admixture Mapping of Glaucoma Genes in African Americans
    Michael A Hauser; Fiscal Year: 2012
    ..These methods typically utilize hundreds of thousands of genetic markers to conduct case-control association tests on genes across the entire human genome...
  49. The Molecular Basis of Alcohol's Actions
    DAVID NIGEL JONES; Fiscal Year: 2010
    ..This may allow future development of novel approaches to prevent alcohols actions, and the identification of genetic markers associated with a predisposition to alcoholism.
  50. Development of a Field Applicable Screening Tool (FAST) kit for detecting resista
    MARTIN JAMES DONNELLY; Fiscal Year: 2013
    ..The FAST diagnostics will include the most important genetic markers for resistance to the IRS insecticides, in addition to any critical pre-identified markers (e.g...
  51. Cortical Excitability: Biomarker and Endophenotype in Combat Related PTSD
    Zhewu Wang; Fiscal Year: 2013
    ..The quantitative trait loci (QTL) approach will be applied to determine genetic markers that are strongly associated with the PTSD endophenotype...
  52. Antiretroviral pharmacogenomics, pharmacokinetics and toxicity in neuroAIDS
    Qing Ma; Fiscal Year: 2013
    ..The identification of genetic markers correlated with antiretroviral pharmacokinetics and neurocognitive function will shed lights on HAND etiology ..
  53. Susceptibility to methylmercury toxicity: A role for cytochrome p450 enzymes
    Matthew D Rand; Fiscal Year: 2013
    ..Identification of CYPs as genetic markers of susceptibility to MeHg would greatly advance risk assessment by bringing new technical abilities to health ..
  54. Resources for Teleost Gene Duplicates and Human Disease
    ..Aim 4 is to develop bioinformatic tools to integrate genetic markers, ESTs, and tiled clones into conserved synteny maps for comparative genomics of humans and teleosts...
  55. Genetic Architecture of Rheumatoid Arthritis in African-Americans
    MARIA IOANA DANILA; Fiscal Year: 2013
    ..The scientific aims of the study are: 1) to determine whether genetic markers of autoimmunity validated in European and Asian populations influence the risk of developing RA in African ..
  56. Resources for Teleost Gene Duplicates and Human Disease
    ..Aim 4 is to develop bioinformatic tools to integrate genetic markers, ESTs, and tiled clones into conserved synteny maps for comparative genomics of humans and teleosts...
  57. Pharmacogenetics of the Antidepressant Response in Geriatric Major Depression
    Greer M Murphy; Fiscal Year: 2010
    ..We now propose to use this unique DNA and clinical resource to identify additional novel genetic markers for antidepressant efficacy and side effects...
    Elyse J Singer; Fiscal Year: 2012
    ..have developed studies to better diagnose neurocognitive disorders in our diverse cohort, to search for host-genetic markers of AIDS-related neurological and psychiatric disorders, and we have increased our collaborations with ..
  59. Comprehensive identification of fusion transcripts in leukemia
    Michael Q Zhang; Fiscal Year: 2010
    ..structural aberrations have been demonstrated to play important roles in tumorogenesis, and used widely as genetic markers in clinical applications including diagnosis, treatment and prognosis...
  60. Acute Kidney Failure in a Cancer ICU
    Joshua A Samuels; Fiscal Year: 2010
    ..This study aims to refine predisposing clinical exposures and evaluate genetic markers that predict the onset and prognosis of AKF in critically ill cancer patients...
    Marla C Dubinsky; Fiscal Year: 2010
    ..markers that are associated with anti-TNF( responsiveness and evaluate their interaction with identified genetic markers. Obtain blood specimens from children with CD and UC for serological immune response testing, mRNA expression ..
  62. Genome Wide Association of Coronary Artery Disease and Related Risk Factors
    Ulrich Broeckel; Fiscal Year: 2012
    ..This approach should enable us to identify genetic markers, which contribute significantly to the risk of CAD, MI and associated risk factors...
  63. Novel Informatics for Highly Reliable Multi-Locus Allele Calling for Embryo Scree
    Matthew Rabinowitz; Fiscal Year: 2009
    ..diseases such as Cystic Fibrosis, and susceptibility to complex disease phenotypes for which the multiple genetic markers are known through whole-genome association (WGA) studies...
    David Harpole; Fiscal Year: 2000
    ..Markers are categorized by hypothetical method of action: molecular genetic markers (Kras, erbB-1, erbB-2, rb, p53, bcl-2), markers of metastatic propensity (angiogenesis factor viii), ..
  65. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009
    ..This proposal is designed to introduce a new tool set of genetic markers for lineage studies in the chondrocytes that form the articular and growth plate cartilage...
    Steven Nadler; Fiscal Year: 1993
    The goal of this research is to use a well-characterized set of polymorphic genetic markers (allozymes) in midwestern populations of Ascaris suum (Nematoda) as a benchmark for developing and characterizing the utility of a new ..
  67. Calcium Absorption and Bone Formation During Puberty
    Steven Abrams; Fiscal Year: 2005
    ..In contrast, serum leptin will be negatively correlated with V0+; 2) Putative genetic markers of osteoporosis, including vitamin D receptor polymorphisms, will be significantly correlated to Ca-abs and ..
  68. Cost-effectiveness of genetic screening for colon cancer
    Sandeep Vijan; Fiscal Year: 2006
    ..Among the most promising of these is the use of genetic markers. Two major types of genetic screening have been proposed and evaluated in early studies...
    Sven Ebbesson; Fiscal Year: 1991
    ..project to determine prevalence of diabetes, hyperinsulinemia, cardiovascular risk factors, and certain genetic markers among Siberian Yupik Eskimos living on St. Lawrence Island in Alaska...
  70. Genetic Determinants of Ankylosing Spondylitis Severity
    Michael Weisman; Fiscal Year: 2005
    ..We will test this model in two stages. First, we will identify genetic markers associated with worse radiological outcomes, greater functional disability, work disability and need for ..
    Richard Duerr; Fiscal Year: 1999
    ..Identification of UC susceptibility genes or linked genetic markers will also permit more accurate genetic counseling for affected individuals and their families...
  72. Genetic markers of white matter integrity in schizophrenia: Relationship to clini
    Vince D Calhoun; Fiscal Year: 2010
    ..The identification of such biomarkers will not only increase our knowledge of the pathophysiology of schizophrenia but also, and most importantly, may help predict an increased risk for this illness even before the onset of symptoms. ..
    Yaron Tomer; Fiscal Year: 2001
    ..The identification of a genetic marker for AITD will allow a better understanding and classification of the diseases. Thus rational treatments could be offered based on the mechanisms initiating the diseases. ..
    HUNTINGTON WILLARD; Fiscal Year: 1992
    ..Abstract) High-resolution physical maps of human chromosomes depend on knowing the order of a series of genetic markers and the distance between adjacent markers...
    Jing Ma; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): We propose to extend our on-going studies of nutritional and biochemical/genetic markers of colorectal and prostate cancer in the Physicians' Health Study (PHS)...