thy 1 antigens

Summary

Summary: A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally identified in the mouse, they are also found in other species including humans, and are expressed on brain neurons and other cells.

Top Publications

  1. ncbi Changes in Thy1 gene expression associated with damaged retinal ganglion cells
    C L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
    Mol Vis 7:192-201. 2001
  2. ncbi Neuronal membrane cholesterol loss enhances amyloid peptide generation
    Jose Abad-Rodriguez
    Cavalieri Ottolenghi Scientific Institute, Universita degli Studi di Torino, Orbassano, Italy
    J Cell Biol 167:953-60. 2004
  3. ncbi Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation
    A O Hueber
    Center d Immunologie INSERM CNRS de Marseille Luminy, Case 906, 13288 Marseille Cedex 9, France
    Curr Biol 7:705-8. 1997
  4. ncbi Downregulation of Thy1 in retinal ganglion cells in experimental glaucoma
    Wei Huang
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, 02114, USA
    Curr Eye Res 31:265-71. 2006
  5. ncbi Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses
    Tanya A Rege
    The Department of Cell Biology, The University of Alabama at Birmingham, VH 648A, 1670 University Boulevard, Birmingham, AL 35294-0019, USA
    Biochim Biophys Acta 1763:991-9. 2006
  6. ncbi Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
  7. ncbi Functionally different GPI proteins are organized in different domains on the neuronal surface
    N Madore
    Molecular Neurobiology Group, New Hunt s House, EM Unit, GKT Medical and Dental School, Guy s Campus, London Bridge, London SE1 9RT, UK
    EMBO J 18:6917-26. 1999
  8. ncbi Differential COX localization and PG release in Thy-1(+) and Thy-1(-) human female reproductive tract fibroblasts
    Laura Koumas
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Lung Biology and Disease Program, Rochester, New York 14642, USA
    Am J Physiol Cell Physiol 283:C599-608. 2002
  9. ncbi Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis
    Tanya A Rege
    The Department Cell Biology and Medical Scientist Training Program, The University of Alabama at Birmingham, VH 648A, 1670 University Blvd, Birmingham, Alabama 35294-0019, USA
    FASEB J 20:1045-54. 2006
  10. ncbi Neuron stress and loss following rodent anterior ischemic optic neuropathy in double-reporter transgenic mice
    Steven L Bernstein
    Departments of Ophthalmology, University of Maryland at Baltimore, School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 48:2304-10. 2007

Research Grants

  1. BIOLOGY OF THE THY-1 ANTIGEN BEARING EPIDERMAL CELLS
    Akira Takashima; Fiscal Year: 2002
  2. FIBROBLAST CD 90 EXPRESSION IN FIBROGENIC SKIN DISORDERS
    James Hagood; Fiscal Year: 2002
  3. Regulation of Fibroblast Phenotype in Lung Fibrosis
    James Hagood; Fiscal Year: 2007
  4. REGULATION OF MASTICATORY MUSCLE FIBER PHENOTYPE
    ARTHUR ENGLISH; Fiscal Year: 2002
  5. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2004
  6. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2006
  7. Mechanisms of optic nerve stroke neuroprotection
    Steven L Bernstein; Fiscal Year: 2010
  8. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2005
  9. Engineering fibrin polymers for enhanced angiogenesis
    THOMAS HARRISON BARKER; Fiscal Year: 2010
  10. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 1999

Detail Information

Publications158 found, 100 shown here

  1. ncbi Changes in Thy1 gene expression associated with damaged retinal ganglion cells
    C L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA
    Mol Vis 7:192-201. 2001
    ..CONCLUSIONS: Thy1 mRNA abundance and expressing cells, decreased in advance of detectable ganglion cell loss caused by three different modalities of damage. This change is independent of the committed step of cell death...
  2. ncbi Neuronal membrane cholesterol loss enhances amyloid peptide generation
    Jose Abad-Rodriguez
    Cavalieri Ottolenghi Scientific Institute, Universita degli Studi di Torino, Orbassano, Italy
    J Cell Biol 167:953-60. 2004
    ....
  3. ncbi Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation
    A O Hueber
    Center d Immunologie INSERM CNRS de Marseille Luminy, Case 906, 13288 Marseille Cedex 9, France
    Curr Biol 7:705-8. 1997
    ..These observations indicate that Thy-1 negatively regulates TCR-mediated signaling and controls activation thresholds during thymocyte differentiation...
  4. ncbi Downregulation of Thy1 in retinal ganglion cells in experimental glaucoma
    Wei Huang
    Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, 02114, USA
    Curr Eye Res 31:265-71. 2006
    ..Thy1 is a surface glycoprotein uniquely expressed in retinal ganglion cells (RGCs) in retina. The aim of this study was to investigate the expression change of Thy1 in a model of experimental glaucoma...
  5. ncbi Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses
    Tanya A Rege
    The Department of Cell Biology, The University of Alabama at Birmingham, VH 648A, 1670 University Boulevard, Birmingham, AL 35294-0019, USA
    Biochim Biophys Acta 1763:991-9. 2006
    ..Ongoing research on the mechanisms of Thy-1 signaling will add to our understanding of the diverse physiologic and pathologic processes in which Thy-1 plays a role...
  6. ncbi Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
    ..Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity...
  7. ncbi Functionally different GPI proteins are organized in different domains on the neuronal surface
    N Madore
    Molecular Neurobiology Group, New Hunt s House, EM Unit, GKT Medical and Dental School, Guy s Campus, London Bridge, London SE1 9RT, UK
    EMBO J 18:6917-26. 1999
    ..Our results demonstrate a structural diversity of the domains occupied by functionally different GPI proteins...
  8. ncbi Differential COX localization and PG release in Thy-1(+) and Thy-1(-) human female reproductive tract fibroblasts
    Laura Koumas
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Lung Biology and Disease Program, Rochester, New York 14642, USA
    Am J Physiol Cell Physiol 283:C599-608. 2002
    ....
  9. ncbi Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis
    Tanya A Rege
    The Department Cell Biology and Medical Scientist Training Program, The University of Alabama at Birmingham, VH 648A, 1670 University Blvd, Birmingham, Alabama 35294-0019, USA
    FASEB J 20:1045-54. 2006
    ..Thy-1 is an important regulator of cell-cell and cell-matrix interactions, with important roles in nerve regeneration, metastasis, inflammation, and fibrosis...
  10. ncbi Neuron stress and loss following rodent anterior ischemic optic neuropathy in double-reporter transgenic mice
    Steven L Bernstein
    Departments of Ophthalmology, University of Maryland at Baltimore, School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 48:2304-10. 2007
    ..The impact of rAION on RGC stress patterns, RGC loss, and their axons after axonal infarct were evaluated...
  11. ncbi Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol
    Antonin Bukovsky
    Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Reprod Biol Endocrinol 1:13. 2003
    ..This mechanism, however, may not operate in abnormal placentae, which show a lack of ER-alpha expression...
  12. ncbi Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation
    A Graziano
    Dipartimento di Discipline Odontostomatologiche, Ortodontiche e Chirurgiche, Università Secondo Ateneo di Napoli, Napoli, Italy
    Cell Death Differ 14:1162-71. 2007
    ..This study provides direct evidence to suggest that osteogenesis and angiogenesis mediated by human SBP-DPSCs may be regulated by distinct mechanisms, leading to the organization of adult bone tissue after stem cell transplantation...
  13. ncbi Characterization of a transformed rat retinal ganglion cell line
    R R Krishnamoorthy
    Department of Pathology and Anatomy, UNT Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Brain Res Mol Brain Res 86:1-12. 2001
    ..These cells may be valuable in understanding of retinal ganglion cell biology and physiology including in vitro manipulations in experimental models of glaucoma...
  14. ncbi Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli
    Yong Zhou
    Department of Pathology, University of Alabama at Birmingham, Volker Hall 668, 1670 University Blvd, Birmingham, AL 35294-0019, USA
    Am J Pathol 165:659-69. 2004
    ..These studies provide a molecular basis for understanding the differential roles of fibroblast subpopulations in fibrotic lung disease through control of latent TGF-beta activation...
  15. ncbi Relationship of lipid rafts to transient confinement zones detected by single particle tracking
    Christian Dietrich
    Department Cell and Developmental Biology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Biophys J 82:274-84. 2002
    ..Overall, our data demonstrate that there are raft-related domains present in certain regions of the plasma membrane of C3H cells, which can persist for tens of seconds...
  16. ncbi Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I
    Tanya A Rege
    Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Cell Res 312:3752-67. 2006
    ..Thy-1 modulates SFK and FAK phosphorylation and subcellular localization, promoting focal adhesion disassembly and migration in fibroblasts, following exposure to TSP-1/hep I...
  17. ncbi Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity
    Thomas H Barker
    Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Cell Res 295:488-96. 2004
    ..We therefore conclude that Thy-1 surface expression regulates fibroblast focal adhesions, cytoskeletal organization and migration by modulating the activity of p190 RhoGAP and Rho GTPase...
  18. ncbi Epigallocatechin gallate, an active ingredient from green tea, attenuates damaging influences to the retina caused by ischemia/reperfusion
    Bo Zhang
    Nuffield Laboratory of Ophthalmology, Walton Street, Oxford OX2 6AW, UK
    Brain Res 1159:40-53. 2007
    ..The results of the study demonstrate that EGCG provides protection to retinal neurones from oxidative stress and ischemia/reperfusion...
  19. ncbi Changes in ocular aquaporin-4 (AQP4) expression following retinal injury
    Adnan Dibas
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, TX, USA
    Mol Vis 14:1770-83. 2008
    ..This study was designed to analyze changes in the expression of AQP4 following elevation of intraocular pressure (IOP) and after intravitreal endothelin-1 injection and the potential involvement of the ubiquitin-dependent proteasome...
  20. ncbi Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis
    James S Hagood
    Department of Pediatrics, University of Alabama, Birmingham, USA
    Am J Pathol 167:365-79. 2005
    ..These results suggest that fibrogenic injury promotes loss of lung fibroblast Thy-1 expression, resulting in enhanced fibrogenesis...
  21. ncbi A system for inducible gene expression in retinal ganglion cells
    John B Kerrison
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 46:2932-9. 2005
    ..To develop a system for inducible gene expression in retinal ganglion cells, Thy1 and ckit promoters were used to direct expression of a second-generation reverse tetracycline transactivator (rtTA2S-M2)...
  22. ncbi Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers
    C Dietrich
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 98:10642-7. 2001
    ..This result demonstrates that cross-linking, a process known to be important for certain cell-signaling processes, can selectively translocate molecules to liquid-ordered domains...
  23. ncbi Expression of Thy-1/lacZ fusion genes in the CNS of transgenic mice
    K A Kelley
    Mount Sinai School of Medicine, Arthur M Fishberg Research Center for Neurobiology, New York, NY 10029
    Brain Res Mol Brain Res 24:261-74. 1994
    ..2 sequences with the lacZ coding region may disrupt normal Thy-1 regulatory signals (or result in the creation of new regulatory elements)...
  24. ncbi Differential expression of platelet-derived growth factor-alpha receptor by Thy-1(-) and Thy-1(+) lung fibroblasts
    J S Hagood
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol 277:L218-24. 1999
    ..Differential expression of the PDGF-alpha receptor supports distinct roles for Thy-1(-) and Thy-1(+) fibroblast populations in developmental and fibrotic processes in the lung...
  25. ncbi Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation
    Thomas H Barker
    Department of Biomedical Engineering, School of Engineering, University of Alabama at Birmingham, 35294, USA
    J Biol Chem 279:23510-6. 2004
    ..This represents a novel role for Thy-1 in the regulation of fibroblast-matrix interactions critical to tissue homeostasis and remodeling...
  26. ncbi Transient confinement zones: a type of lipid raft?
    Yun Chen
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
    Lipids 39:1115-9. 2004
    ..Here we review transient confinement zones and some of their implications for membrane structure and function...
  27. ncbi Thy-1 associated pp85--90 is a potential docking site for SH2 domain-containing signal transduction molecules
    G A Durrheim
    Department of Medical Physiology and Biochemistry, University of Stellenbosch Medical School, Tygerberg, South Africa
    Cell Biol Int 25:33-42. 2001
    ....
  28. ncbi Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes
    Laura Koumas
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 163:1291-300. 2003
    ....
  29. ncbi Fibroblast subsets in the human orbit: Thy-1+ and Thy-1- subpopulations exhibit distinct phenotypes
    Laura Koumas
    Departments of Microbiology and Immunology, James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Eur J Immunol 32:477-85. 2002
    ..These observations suggest that fibroblast subsets in the human orbit play distinct roles in the regulation of immune and inflammatory responses crucial in the initiation and development of thyroid-associated ophthalmopathy...
  30. ncbi Most IL-4-producing gamma delta thymocytes of adult mice originate from fetal precursors
    Kalliopi Grigoriadou
    , , Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France
    J Immunol 171:2413-20. 2003
    ....
  31. ncbi Differentiation of marrow stromal cells into photoreceptors in the rat eye
    Anthony Kicic
    Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute, affiliated with the Center of Ophthalmology and Visual Science, University of Western Australia, Nedlands, 6009, Western Australia, Australia
    J Neurosci 23:7742-9. 2003
    ..Our results establish a proof of concept for CD90+ MSC differentiation with autologous transplantation, which may provide a promising therapeutic strategy for the treatment of some forms of genetically inherited retinal degenerations...
  32. ncbi Preparation and functional analysis of tumor-infiltrating stroma cells using bone marrow chimera mice
    Hirohito Ishigaki
    Department of Gastroenterology and Hematology, Shiga University of Medical Science, Ohtsu, Shiga, Japan
    Microbiol Immunol 50:655-62. 2006
    ..In our system, tumors did not inhibit T cell responses directly, but unknown factors from tumors affected immunosuppression by TISC...
  33. ncbi Culture conditions and single growth factors affect fate determination of mouse spermatogonial stem cells
    Hiroshi Kubota
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 71:722-31. 2004
    ..The stem cell enrichment strategies and the culture methods described provide a reproducible and powerful assay system to establish the effect of various environmental factors on SSC survival and replication in vitro...
  34. ncbi Neuronal differentiation of murine bone marrow Thy-1- and Sca-1-positive cells
    F Locatelli
    Centro Dino Ferrari, Dipartimento di Scienze Neurologiche, , I.R.C.C.S. Ospedale Maggiore Policlinico, Milan, Italy
    J Hematother Stem Cell Res 12:727-34. 2003
    ..Although cell fusion phenomena with the host cells could not be ruled out, bone marrow-derived neurosphere transplantation could be a strategy for cellular mediated gene therapy...
  35. ncbi Muller glia induce retinal progenitor cells to differentiate into retinal ganglion cells
    Jing Yao
    China-Australia Link Laboratory, Department of Ophthalmology, Eye and ENT Hospital, and Department of Anatomy and Embryo, Shanghai Medical College, Fudan University, Shanghai, PR China
    Neuroreport 17:1263-7. 2006
    ..Identification of Muller glia-derived factors will be made to elucidate the molecular mechanisms of neurogenesis...
  36. ncbi Platelet-derived growth factor plays a critical role to convert bone marrow cells into glomerular mesangial-like cells
    Akira Suzuki
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan
    Kidney Int 65:15-24. 2004
    ..CONCLUSION: These results indicate that PDGF-B plays a critical role to direct bone marrow-derived cells toward mesangial-like cells both in vitro and in vivo...
  37. ncbi Angiogenic potential of CD44+ CD90+ multipotent CNS stem cells in vitro
    Kazuhiko Oishi
    Department of Pharmacology, Meiji Pharmaceutical University, Tokyo 204 8588, Japan
    Biochem Biophys Res Commun 349:1065-72. 2006
    ..These results indicate that CD44(+) CD90(+) cells have the ability to generate neurospheres and to form vascular tubes...
  38. ncbi Thy1-positive mesenchymal cells promote the maturation of CD49f-positive hepatic progenitor cells in the mouse fetal liver
    Toshitaka Hoppo
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hepatology 39:1362-70. 2004
    ....
  39. ncbi In vitro differentiation and maturation of mouse embryonic stem cells into hepatocytes
    Takamichi Ishii
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan
    Exp Cell Res 309:68-77. 2005
    ..In conclusion, coculture with Thy1-positive cells in vitro induced the maturation of AFP-producing cells isolated from ES cell cultures into hepatocytes...
  40. ncbi Enhanced myofibroblastic differentiation and survival in Thy-1(-) lung fibroblasts
    Yan Y Sanders
    Department of Pediatrics, Pulmonary Division, University of Alabama Birmingham, AL 35294 0019, USA
    Am J Respir Cell Mol Biol 36:226-35. 2007
    ..Transfection of Thy-1 into Thy-1(-) cells inhibits collagen matrix contraction and reduces cell survival. Our data indicate that Thy-1 regulates myogenic gene expression, myofibroblastic differentiation, and survival in lung fibroblasts...
  41. ncbi Abortive activation precedes functional deletion of CD8+ T cells following encounter with self-antigens expressed by resting B cells in vivo
    Joanne M Fraser
    University of Minnesota, Department of Gastroenterology Medicine, Minneapolis, MN, USA
    Immunology 119:126-33. 2006
    ....
  42. ncbi Characterization of two distinct liver progenitor cell subpopulations of hematopoietic and hepatic origins
    V Corcelle
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    Exp Cell Res 312:2826-36. 2006
    ..Oval cells require the hepatic niche to proliferate, while cells mobilized from the circulation proliferate and transdifferentiate into hepatocytes without evidence of cell fusion...
  43. ncbi Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal
    J C Young
    Cytotherapy 6:328-36. 2004
    ..DISCUSSION: Our studies suggest that HDAC inhibitors can induce ex vivo expansion of human HSC, and may improve engraftment in hematopoietic transplant patients when cell dose is limiting...
  44. ncbi [Differentiation of mesenchymal stem cells into cardiomyocytes induced by cardiomyocytes]
    Ting-Zhong Wang
    Department of Cardiovascular Medicine, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:270-5. 2005
    ..CONCLUSION: Direct cell-to-cell contact between MSCs and adult cardiomyocytes may induce differentiation of MSCs into cardiomyocytes...
  45. ncbi Stem cell reconstitution of autoimmune T cell repertoires
    Andrea E Edling
    Department of Immunology, NB30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Neuroimmunol 169:126-36. 2005
    ..Our study indicates that sustained autoimmune memory may not simply be due to the persistence of long-lived memory T cells, but may also involve bone marrow regeneration and replacement of the autoreactive T cell repertoire...
  46. ncbi Axon regeneration in peripheral nerves is enhanced by proteoglycan degradation
    Mari L Groves
    Department of Cell Biology, 405P Whitehead Building, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Exp Neurol 195:278-92. 2005
    ....
  47. ncbi Hematopoietic stem cells do not engraft with absolute efficiencies
    Fernando D Camargo
    Program in Cell and Molecular Biology and the Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77098, USA
    Blood 107:501-7. 2006
    ..Altogether, our results indicate that even an extremely homogeneous HSC population, based on phenotype and dye efflux, cannot reconstitute mice at absolute efficiencies...
  48. ncbi Neuro-glial differentiation of human bone marrow stem cells in vitro
    P Bossolasco
    Fondazione Matarelli, Milan, Italy
    Exp Neurol 193:312-25. 2005
    ..Moreover, unidentified soluble factors provided by the conditioned media and cellular contacts in co-culture systems were effective in inducing the neuro-glial phenotype, further supporting the adult BM neural differentiative capability...
  49. ncbi [A study on stem cell mobilization after partial liver transplantation in rats]
    Feng Liu
    Institute of Hepatology, People's Hospital, Peking University, Beijing 100044, China
    Zhonghua Gan Zang Bing Za Zhi 13:839-43. 2005
    ..Sry+ cells could be detected in portal tract areas and few Sry+/CD34+ and Sry+/Thy-1.1+cells were detected. CONCLUSION: In the PLTx group, the stem cells in the bone marrow were mobilized and stem cells in the liver were activated...
  50. ncbi Human skin-derived stem cells migrate throughout forebrain and differentiate into astrocytes after injection into adult mouse brain
    Marzia Belicchi
    Department of Neurological Sciences, Stem Cell Laboratory, Centro Dino Ferrari, IRCCS Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    J Neurosci Res 77:475-86. 2004
    ....
  51. ncbi Cell growth and differentiation of different hepatic cells isolated from fetal rat liver in vitro
    Henning C Fiegel
    Department of Pediatric Surgery, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Tissue Eng 12:123-30. 2006
    ..Thus, these cells might be useful for concepts of cell-based therapies. However, further efforts must be undertaken to define the biological, ethical, and legal aspects of using fetal cells...
  52. ncbi Transcriptomic fingerprinting of bone marrow-derived hepatic beta2m-/Thy-1+ stem cells
    Charles Wang
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Biochem Biophys Res Commun 327:252-60. 2005
    ....
  53. ncbi Bone marrow progenitors are not the source of expanding oval cells in injured liver
    Anuradha Menthena
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Stem Cells 22:1049-61. 2004
    ..These data demonstrate that the sources of oval cells and small hepatocytes in the injured liver are endogenous liver progenitors and that they do not arise through transdifferentiation from BM cells...
  54. ncbi Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells
    Nancy M Joseph
    Department of Internal Medicine, 1500 East Medical Center Drive, University of Michigan, Ann Arbor, MI 48109-0934, USA
    Development 131:5599-612. 2004
    ..Nerve development is thus more complex than was previously thought, involving NCSC self-renewal, lineage commitment and multilineage differentiation...
  55. ncbi Induction of glial glutamate transporters in adult mesenchymal stem cells
    Isabelle de Hemptinne
    , , Brussels, Belgium
    J Neurochem 91:155-66. 2004
    ..Although the astrocytic nature of these cells remains to be confirmed, this observation gives support to the study of mesenchymal stem cells as a promising tool for the treatment of neurological diseases involving glutamate excitoxicity...
  56. ncbi Tissue resident cells play a dominant role in arteriogenesis and concomitant macrophage accumulation
    Eugen Khmelewski
    Department of Cardiology, University Hospital Hamburg, Hamburg, Germany
    Circ Res 95:E56-64. 2004
    ..The full text of this article is available online at http://circres.ahajournals.org...
  57. ncbi Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
    Martin C Herzig
    Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, , , Germany
    Nat Neurosci 7:954-60. 2004
    ....
  58. ncbi Marrow stromal cells (MSC): a species comparison
    Anthony Kicic
    Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute, Centre of Ophthalmology and Visual Science, University of Western Australia, Nedlands, 6009, Western Australia, Australia
    Adv Exp Med Biol 533:407-14. 2003
  59. ncbi Evidence of marginal-zone B cell-positive selection in spleen
    Lijun Wen
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Immunity 23:297-308. 2005
    ..These data indicate that positive selection can occur in developing B cells and that BCR signal strength is a key factor in deciding between two functionally distinct mature B cell compartments in the microenvironment of the spleen...
  60. ncbi Expression of the neuronal surface glycoprotein Thy-1 is under post-transcriptional control, and is spatially regulated, in the developing olfactory system
    G P Xue
    Norman and Sadie Lee Research Centre, Laboratory of Neurobiology, National Institute for Medical Research, Mill Hill, London, UK
    Development 109:851-64. 1990
    ..abstract truncated at 400 words)..
  61. ncbi Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement
    P C Sandel
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 166:5935-44. 2001
    ....
  62. ncbi Phenotypic distinction and functional characterization of pro-B cells in adult mouse bone marrow
    M P Mojica
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84132, USA
    J Immunol 166:3042-51. 2001
    ..These studies have therefore defined and isolated a B lymphoid-committed progenitor population at a developmental stage corresponding to the initial expression of CD45R...
  63. ncbi Characteristics of progenitor cells derived from adult ciliary body in mouse, rat, and human eyes
    Hangxiu Xu
    Glaucoma Research Laboratory, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 48:1674-82. 2007
    ..To isolate and characterize progenitor cells derived from adult mammalian ciliary body...
  64. ncbi CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Pathol 170:1229-40. 2007
    ..These observations define an essential role for CCR6 expression by B lymphocytes in localizing to intestinal lymphoid structures and in ILF development...
  65. ncbi Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells
    T Oida
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 164:3616-26. 2000
    ..These findings underscore the role of gut CP in the early extrathymic maturation of CD8alphaalpha+ IEL, including cell-surface expression of alphaEbeta7 integrin, CD3epsilon gene transcription, and TCR gene rearrangements...
  66. ncbi CD90-positive cells, an additional cell population, produce laminin alpha2 upon transplantation to dy(3k)/dy(3k) mice
    So ichiro Fukada
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Exp Cell Res 314:193-203. 2008
    ..Thus, CD90(+) cells are a newly identified additional cell fraction that increased during skeletal muscle regeneration in vivo and could be another cell source for therapy for lama2-deficient muscular dystrophy...
  67. ncbi [Immunomagnetic beads sorting and functional identification of human spermatogonial stem cells]
    Yanfeng Li
    Department of Urology, Daping Hospital, Institute of Field Surgery, The Third Military Medical University, Chongqing 400042, China
    Zhonghua Nan Ke Xue 10:567-71. 2004
    ..The very nature of spermatogonial stem cells (SSC) is still poorly understood. The objective of this study is to explore the specific markers of human SSC and search for the suitable method for their isolation and functional identification...
  68. ncbi Enhanced visualization of axonopathy in EAE using thy1-YFP transgenic mice
    P G Bannerman
    Neurology Research, Shriners Hospital for Children, Sacramento, CA 95817, United States
    J Neurol Sci 260:23-32. 2007
    ..Finally, we show the accumulation of hyperphosphorylated neurofilament-H (hyperP-NF-H) expression in YFP+, lesioned WM areas and in a subpopulation of neuronal perikarya in the lumbar spinal cords of EAE mice...
  69. ncbi Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats
    Anna C Piscaglia
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Gastroenterology 133:619-31. 2007
    ..In the present study, we assessed the involvement of G-CSF during oval cell activation...
  70. ncbi Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet
    Janina E E Tirnitz-Parker
    School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Australia
    Int J Biochem Cell Biol 39:2226-39. 2007
    ..These novel murine oval cell lines, together with a reliable method for isolation and culture of primary oval cells, will provide a useful tool for investigating the contribution of oval cells to liver regeneration...
  71. ncbi Selection using the alpha-1 integrin (CD49a) enhances the multipotentiality of the mesenchymal stem cell population from heterogeneous bone marrow stromal cells
    David A Rider
    Laboratory of Stem Cells and Tissue Repair, Institute of Molecular and Cell Biology, Singapore, Singapore
    J Mol Histol 38:449-58. 2007
    ..These results thus support the use of CD49a selection for the enrichment of mesenchymal stem cells, and describes a strategy for selecting the most multipotential cells from a heterogeneous pool of bone marrow mononuclear stem cells...
  72. ncbi 3D-reconstruction and functional properties of GFP-positive and GFP-negative granule cells in the fascia dentata of the Thy1-GFP mouse
    Mario Vuksic
    Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Hippocampus 18:364-75. 2008
    ..Taken together, this study provides morphometric data on granule cells of mice bred on a C57BL/6 background and establishes the Thy1-GFP mouse as a tool to study granule cell neurobiology...
  73. ncbi Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis
    M Nangaku
    Molecular and Cellular Nephrology, Institute of Medical Sciences Tokai University School of Medicine, Kanagawa, Japan
    Kidney Int 60:641-52. 2001
    ..Megsin is a novel member of the serine protease inhibitor (serpin) superfamily. To elucidate functional roles of this gene, we cloned megsin in rodents and investigated its role in a rat nephritis model...
  74. ncbi Lung cells from neonates show a mesenchymal stem cell phenotype
    Kenneth T Hennrick
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Respir Crit Care Med 175:1158-64. 2007
    ..Mesenchymal stem cells have been isolated from adult bone marrow, peripheral blood, adipose tissue, trabecular bone, articular synovium, and bronchial submucosa...
  75. ncbi Active form of Notch members can enforce T lymphopoiesis on lymphoid progenitors in the monolayer culture specific for B cell development
    Katsuto Hozumi
    Department of Immunology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Immunol 170:4973-9. 2003
    ..These results indicate that in vitro T lymphopoiesis is inducible by signaling via Notch family members in a lineage-specific manner but shares other stroma-derived factors including IL-7 with B lymphopoiesis...
  76. ncbi Regional brain cytochrome oxidase activity in beta-amyloid precursor protein transgenic mice with the Swedish mutation
    C Strazielle
    Laboratoire de Pathologie Moléculaire et Cellulaire en Nutrition and the Service de Microscopie Electronique, Faculte de Medecine, Universite Henri Poincare, 7 Allée de la Forêt de Haye, 54500 Vandoeuvre les Nancy, France
    Neuroscience 118:1151-63. 2003
    ....
  77. ncbi Hepatic lineages isolated from developing rat liver show different ways of maturation
    Henning C Fiegel
    Department of Pediatric Surgery, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Biochem Biophys Res Commun 305:46-53. 2003
    ..Thy1-positive cells from fetal livers express liver specific genes. The data suggest that Thy1-positive hepatic cells develop towards hepatic stem cells, and hepatoblasts develop towards mature hepatocytes of the adult liver...
  78. ncbi Adenovirus-mediated gene transfer of Bcl-xL impedes neurite regeneration in vitro
    Toshiyuki Oshitari
    Department of Ophthalmology, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba City 260 8670, Japan
    Neuroreport 14:1159-62. 2003
    ..However, neurite regeneration in adeno-treated retinas was less than that of vector-free retina. These results suggest that the usefulness of adenovirus vectors for gene therapy for retinal ganglion cells may be limited...
  79. ncbi Early defect prethymic in bone marrow T cell progenitors in athymic nu/nu mice
    Devavani Chatterjea-Matthes
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 171:1207-15. 2003
    ..We show that defects in bone marrow prethymic T cell development can also contribute to T cell deficiency in nu/nu mice...
  80. ncbi Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers
    Bryon E Petersen
    Department of Pathology, Immunology and Laboratory Medicine, College of Medical, University of Florida, Gainesville, FL 32610, USA
    Hepatology 37:632-40. 2003
    ..Our system works with most strains of mouse, which will facilitate both in vivo and in vitro studies of mouse hepatic oval cells...
  81. ncbi Lymphoid precursors in intestinal cryptopatches express CCR6 and undergo dysregulated development in the absence of CCR6
    Andreas Lugering
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 171:2208-15. 2003
    ..CCR6 was absent from the vast majority of mature IEL. CCR6 is present on lymphocyte precursors in cryptopatches, expressed transiently during extrathymic IEL development, and is required for homeostatic regulation of intestinal IEL...
  82. ncbi Characterization of thymic progenitors in adult mouse bone marrow
    S Scott Perry
    Department of Pathology, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA
    J Immunol 170:1877-86. 2003
    ..Furthermore, they note disparity in B and T cell expansion from this lymphoid progenitor population and suggest that it contains the progenitor primarily responsible for seeding the thymus throughout life...
  83. ncbi Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development
    Kyoko Hayakawa
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 197:87-99. 2003
    ..These findings demonstrate that B-1 positive selection, resulting in the production of natural serum ATA, arises independently from the major pathway of BM B cell development and selection...
  84. ncbi Sca-1 and Thy-1 accelerate neuron-like differentiation in bone marrow stromal cells
    Takashi Mizobe
    Department of Neurosurgery, Kobe University Graduate School of Medicine
    Kobe J Med Sci 52:119-25. 2006
    ..Neuron-like differentiation of bone marrow cells can be enhanced by selection using cell surface proteins...
  85. ncbi Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy
    Terry J Smith
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Clin Endocrinol Metab 87:385-92. 2002
    ..These observations enhance our understanding of orbital adipogenesis and define previously unrecognized differences between fibroblasts from the extraocular muscle and connective tissue...
  86. ncbi A genetic determinant that specifically regulates the frequency of hematopoietic stem cells
    Sean J Morrison
    Howard Hughes Medical Institute and Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 168:635-42. 2002
    ..This suggests that to affect HSC frequencies, the product(s) of this locus likely depend on interactions with unlinked modifying loci...
  87. ncbi Two populations of Thy1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells
    Naoko Kamo
    Dept of Surgery, Graduate School of Medicine, Kyoto Univ, Shogoin, Kyoto, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G526-34. 2007
    ..In conclusion, these results suggest that in vitro maturation of HPCs promoted by gp38-positive cells may be opposed by an inhibitory effect of gp38-negative cells, which likely maintain the immature, proliferative state of HPCs...
  88. ncbi CD34(+) cell subsets and long-term culture colony-forming cells evaluated on both autologous and normal bone marrow stroma predict long-term hematopoietic engraftment in patients undergoing autologous peripheral blood stem cell transplantation
    F Lanza
    Section of Hematology and BMT Unit, Department of Biomedical Sciences and Advanced Therapies, University Hospital, Ferrara, Italy
    Exp Hematol 29:1484-93. 2001
    ....
  89. ncbi Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats
    Liya Pi
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, College of Medicine, Gainesville 32610 0275, USA
    Gastroenterology 128:2077-88. 2005
    ..To understand the molecular mechanism underlying this process, we investigated the role of connective tissue growth factor (CTGF), one of the candidate genes differentially expressed in Thy-1+ oval cells, in this liver injury model...
  90. ncbi X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
    V L Godfrey
    Biology Division, Oak Ridge National Laboratory, TN 37831 8077
    Am J Pathol 138:1379-87. 1991
    ..Raising scurfy mice in a specific-pathogen-free environment does not alter disease expression. Thus, while our findings indicate that scurfy disease may be the result of immune dysfunction, it is not a classic immunodeficiency...
  91. ncbi Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors
    S Okada
    Department of Medicine, Jichi Medical School, Tochigi ken, Japan
    Exp Hematol 20:546-51. 1992
    ..Therefore, it is concluded that IL-6 acts directly on hemopoietic stem cells to enhance their proliferation...
  92. ncbi Novel method for in vitro depletion of T cells by monoclonal antibody-targeted photosensitization
    T Berki
    Department of Immunology and Biotechnology, University Medical School of Pecs, Hungary
    J Immunol Methods 211:139-46. 1998
    ..This method can be useful for selective destruction of one population (target cell) in an in vitro heterogeneous cell mixture, e.g., in bone marrow transplants for T cell depletion to avoid graft vs. host reaction...
  93. ncbi Thymic hormones and prostaglandins. I. Lack of stimulation of prostaglandin production by thymic hormones
    F Homo-Delarche
    INSERM U 25, Hopital Necker, Paris, France
    Prostaglandins 38:183-96. 1989
    ..These results do not support the hypothesis that prostaglandins could act as mediators of thymic hormones...
  94. ncbi Inhibition of natural killer activity by calcitonin gene-related peptide
    Y Umeda
    Department of Chemotherapy and Biochemistry, Nippon Roche Research Center, Kamakura, Japan
    Immunopharmacol Immunotoxicol 11:309-20. 1989
    ..Our present study suggests that CGRP inhibits NK cell activity by increasing the intracellular cyclic AMP concentration. CGRP may be implicated in the regulation of NK function...
  95. ncbi T-cell-activating monoclonal antibodies, reacting with both leukocytes and erythrocytes, recognize the guinea pig Thy-1 differentiation antigen: characterization and cloning of guinea pig CD90
    H Schafer
    Department of Immunology, Robert Koch Institute, Berlin, Germany
    Cell Immunol 197:116-28. 1999
    ..While treatment of erythrocytes and lymphocytes with GPI-specific phospholipase C largely decreased reactivity with mAb H154, T cells retained the proliferative response to antibody and phorbol esters...
  96. ncbi The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase
    I N Day
    University Department of Clinical Biochemistry, Southampton General Hospital, U K
    Biochem J 268:521-4. 1990
    ..The human PGP9.5 gene, described here, spans 10 kb, contains nine exons and displays 5' features some common to many genes and some common with neurofilament neuron-specific enolase and Thy-1-antigen gene 5' regions...
  97. ncbi Flow cytometric analysis of Thy-1 expression in myelodysplastic syndrome
    T Inaba
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan
    Int J Hematol 68:403-10. 1998
    ..In contrast, expression of Thy-1 did not seem essential to the leukemic transformation in MDS though the patients with high Thy-1 expression might have poorer prognosis compared with those with low Thy-1 expression...
  98. ncbi Interleukin-6 is required for pristane-induced plasma cell hyperplasia in mice
    D A Dedera
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Haematol 94:53-61. 1996
    ..These data demonstrate that IL-6 is required for pristane-induced hyperplasia of polyclonal plasma cells in mice...
  99. ncbi Leucocyte membrane antigens on mouse granulated metrial gland cells
    D D Mukhtar
    Human Morphology, Faculty of Medicine, University of Southampton, U K
    J Reprod Immunol 15:269-79. 1989
    ..GMG cells were found to express both the asialo-GM1 antigen and the Thy-1 antigen. GMG cells did not express the Lyt-1, Lyt-2, Mac-1, L3T4 or IgM antigens. These results provide new evidence that GMG cells are a type of NK cell...
  100. ncbi Thy-1 antigen-mediated adhesion of mouse lymphoid cells to stromal cells of haemopoietic origin
    Y Irlin
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Immunol Lett 33:233-7. 1992
    ..1 and MBA-15 contain on their surface a specific ligand for the Thy-1 molecule. Cell-cell interaction via this ligand and the molecule on the cell surface may be an important step for development of certain lineages of cells...
  101. ncbi Identification of CD34+ subsets after glycoprotease selection: engraftment of CD34+Thy-1+Lin- stem cells in fetal sheep
    D R Sutherland
    Oncology Research, The Toronto Hospital, Toronto, Ontario, Canada
    Exp Hematol 24:795-806. 1996
    ....

Research Grants115 found, 100 shown here

  1. BIOLOGY OF THE THY-1 ANTIGEN BEARING EPIDERMAL CELLS
    Akira Takashima; Fiscal Year: 2002
    ..Through these five specific aims they intend to uncover unique activities of IL-13 in the skin. ..
  2. FIBROBLAST CD 90 EXPRESSION IN FIBROGENIC SKIN DISORDERS
    James Hagood; Fiscal Year: 2002
    ..Establishing the role of fibroblast Thy-1/CD90 expression in human fibrogenic skin diseases is likely to unlock mechanisms of fibroblast activation and lead to more effective treatments for fibrotic disorders in skin and other tissues. ..
  3. Regulation of Fibroblast Phenotype in Lung Fibrosis
    James Hagood; Fiscal Year: 2007
    ..Each of these aims will be addressed in a vertically-integrated approach using in vitro studies, relevant animal models and well-characterized human samples. ..
  4. REGULATION OF MASTICATORY MUSCLE FIBER PHENOTYPE
    ARTHUR ENGLISH; Fiscal Year: 2002
    ..The new knowledge generated will impact significantly several areas of clinical dentistry. ..
  5. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2004
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  6. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2006
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  7. Mechanisms of optic nerve stroke neuroprotection
    Steven L Bernstein; Fiscal Year: 2010
    ....
  8. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2005
    ..abstract_text> ..
  9. Engineering fibrin polymers for enhanced angiogenesis
    THOMAS HARRISON BARKER; Fiscal Year: 2010
    ..This project will have direct relevance to wound healing and regenerative medicine by establishing new methods to manipulate fibrin for specific clinical outcomes. ..
  10. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 1999
    ..Finally, the subsets of donor cells which induce tolerance, and subsets of recipient cells which maintain tolerance will be identified in adoptive transfer studies. ..
  11. LY-1 B CELLS--DEVELOPMENTAL ORIGINS AND V GENE
    Richard Hardy; Fiscal Year: 2000
    ..Cumulatively, these studies will provide a clearer picture of fetal and adult B lymphopoiesis and distinguish whether the modes of selection affecting developing B cells are similar or different during these two ontogenic timi s. ..
  12. Mechanisms of optic nerve stroke neuroprotection
    Steven Bernstein; Fiscal Year: 2009
    ....
  13. Mapping for Specialized Domains for FCeRI Signaling & Internalization
    Bridget S Wilson; Fiscal Year: 2010
    ..Results of these analyses will contribute important new insight into the nature and assembly of membrane microdomains controlling immune cell signaling. ..
  14. BONE MARROW DERIVED OVAL CELLS FOR LIVER REGENERATION
    Bryon Petersen; Fiscal Year: 2004
    ..These data will be critical for developing novel therapeutic strategies for the treatment of liver disease. ..
  15. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2007
    ..However, the differential resistance is lost in p53"'" mice and in Bcl-2 transgenic mice. We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..
  16. Translocation and Function of Nuclear Ferritin
    James Connor; Fiscal Year: 2004
    ..abstract_text> ..
  17. Identifying Gene Interactions in SLE by Mixed Chimeras
    Eric Sobel; Fiscal Year: 2006
    ..To use a gene array approach to identify differences in gene expression. Successful completion of these experiments would identify a novel method of systematically identifying epistatic interactions in an important murine model of SLE. ..
  18. Exercise, neurotrophins and axon regeneration in the PNS
    ARTHUR ENGLISH; Fiscal Year: 2007
    ..Its potential for clinical use with low cost and very high benefit is great. This project provides a unique opportunity to provide answers important to questions that will strengthen the basis for such clinical use. ..
  19. Domains for FcERI Signaling & Internalization
    Bridget Wilson; Fiscal Year: 2003
    ..This work will define roles for microdomains in the processes of signal initiation, signal propagation and receptor internalization. ..
  20. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2004
    ..GVHD will be monitored by clinical signs, survival, and histopathology. ..
  21. Inducible Gene Expression in Retinal Ganglion Cells
    John Kerrison; Fiscal Year: 2004
    ..abstract_text> ..
  22. Isolation and Characterization of a Ferritin Receptor
    James Connor; Fiscal Year: 2005
    ..This project will significantly alter our thinking on brain iron transport and open novel directions for research in oligodendrocyte biology and diagnositic and therapeutic strategies in demyelinating disorders ..
  23. Stem cells in liver regeneration: fusion or plasticity
    Bryon Petersen; Fiscal Year: 2009
    ..abstract_text> ..
  24. BONE MARROW AS A SOURCE FOR PANCREATIC STEM CELLS
    Bryon Petersen; Fiscal Year: 2002
    ..The same data could potentially provide a valuable resource for future tissue engineering and cell therapy technique interventions in pancreatic regeneration. ..