cd45 antigens

Summary

Summary: High-molecular weight glycoproteins uniquely expressed on the surface of all leukocytes and their hemopoietic progenitors. The CD45 family consists of multiple members that are all products of a single gene. CD45 expression is necessary for signaling through the T-cell receptor.

Top Publications

  1. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
  2. pmc Myogenic specification of side population cells in skeletal muscle
    Atsushi Asakura
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6 Canada
    J Cell Biol 159:123-34. 2002
  3. pmc Identification of myogenic-endothelial progenitor cells in the interstitial spaces of skeletal muscle
    Tetsuro Tamaki
    Department of Physiology, Division of Human Structure and Function, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Cell Biol 157:571-7. 2002
  4. pmc Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
    J D Sedgwick
    Institute for Virology and Immunobiology, University of Wurzburg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 88:7438-42. 1991
  5. ncbi CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
    J Irie-Sasaki
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 409:349-54. 2001
  6. pmc CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules
    Shoham Shivtiel
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 205:2381-95. 2008
  7. ncbi Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis
    Jennifer N Solomon
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Glia 53:744-53. 2006
  8. ncbi The role of CD45 and CD45-associated molecules in T cell activation
    J G Altin
    Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, Australian National University, Canberra, Australia
    Immunol Cell Biol 75:430-45. 1997
  9. ncbi CD45 isoforms in T cell signalling and development
    Louise McNeill
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Immunol Lett 92:125-34. 2004
  10. pmc Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages
    Elena Chertova
    AIDS Vaccine Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    J Virol 80:9039-52. 2006

Research Grants

  1. CD45 Pretargeted Radioimmunotherapy for AML
    Oliver W Press; Fiscal Year: 2013
  2. Alpha Radioimmunotherapy for Lymphoma Treatment
    BRENDA MARIE SANDMAIER; Fiscal Year: 2013
  3. Bispecific Antibody Engineering for AML RIT
    Oliver W Press; Fiscal Year: 2013
  4. THERAPY OF LYMPHOMA/LEUKEMIA WITH MONOCLONAL ANTIBODIES
    Oliver W Press; Fiscal Year: 2013
  5. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
  6. MESANGIAL CELL IN DEVELOPMENT OF GLOMERULOSCLEROSIS
    Sharon Adler; Fiscal Year: 1992
  7. GENETIC ANALYSIS OF REGULATION AND FUNCTION OF CD45
    William Raschke; Fiscal Year: 2002
  8. Radioimmunotherapy of CD20+ Lymphomas & CD45+Leukemias
    JOHN PAGEL; Fiscal Year: 2008
  9. Radioimmunotherapy of Acute Leukemia
    Eneida Nemecek; Fiscal Year: 2007
  10. B220+DN Tcells in Mucosal Tolerance and Inflammation
    ABDEL HAMAD; Fiscal Year: 2005

Detail Information

Publications241 found, 100 shown here

  1. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  2. pmc Myogenic specification of side population cells in skeletal muscle
    Atsushi Asakura
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6 Canada
    J Cell Biol 159:123-34. 2002
    ....
  3. pmc Identification of myogenic-endothelial progenitor cells in the interstitial spaces of skeletal muscle
    Tetsuro Tamaki
    Department of Physiology, Division of Human Structure and Function, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Cell Biol 157:571-7. 2002
    ..2001). These findings suggest that myo-endothelial progenitors reside in the interstitial spaces of mammalian skeletal muscles, and that they can potentially contribute to postnatal skeletal muscle growth...
  4. pmc Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
    J D Sedgwick
    Institute for Virology and Immunobiology, University of Wurzburg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 88:7438-42. 1991
    ..In normal CNS, a very small population of blood-derived CD45high-expressing cells are present; most MHC class II expression is associated with these few cells and not with the resident microglia...
  5. ncbi CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
    J Irie-Sasaki
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 409:349-54. 2001
    ..Our data identify an unexpected and novel function for CD45 as a haematopoietic JAK phosphatase that negatively regulates cytokine receptor signalling...
  6. pmc CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules
    Shoham Shivtiel
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 205:2381-95. 2008
    ..Uncoupling environmental and intrinsic defects in chimeric mice, we demonstrated that CD45 regulates progenitor movement and retention by influencing both the hematopoietic and nonhematopoietic compartments...
  7. ncbi Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis
    Jennifer N Solomon
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Glia 53:744-53. 2006
    ..Thus, we demonstrate that the microgliosis present in spinal cord tissue of mSOD mice is primarily due to an expansion of resident microglia and not to the recruitment of microglial precursors from the circulation...
  8. ncbi The role of CD45 and CD45-associated molecules in T cell activation
    J G Altin
    Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, Australian National University, Canberra, Australia
    Immunol Cell Biol 75:430-45. 1997
    ..This review aims to summarize recent findings on the role of CD45 and CD45-associated molecules in T cell activation, and to highlight issues that seem relevant to ongoing research in this area...
  9. ncbi CD45 isoforms in T cell signalling and development
    Louise McNeill
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Immunol Lett 92:125-34. 2004
    ..Achieving a thorough understanding of the biological reasons for the existence and tight regulation of CD45 isoform expression in immune cells remains one of the outstanding challenges in the CD45 research field...
  10. pmc Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages
    Elena Chertova
    AIDS Vaccine Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    J Virol 80:9039-52. 2006
    ..MDM-derived HIV contained 26 of 37 proteins previously found in exosomes, consistent with the idea that HIV uses the late endosome/multivesicular body pathway during virion budding from macrophages...
  11. ncbi Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells
    Gersende Caron
    Unité Mixte Institut National de la Santé et de la Recherche Médicale 564, University Hospital, Angers, France
    J Immunol 175:1551-7. 2005
    ..They also suggest that some components from invading microorganisms may directly stimulate effector memory T cells located in tissues by up-regulating cytokine and chemokine production...
  12. ncbi Control of intestinal inflammation by regulatory T cells
    B Singh
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 182:190-200. 2001
    ....
  13. ncbi Peripheral macrophage recruitment in cuprizone-induced CNS demyelination despite an intact blood-brain barrier
    Eileen J McMahon
    Department of Microbiology and Immunology, University of North Carolina, 27599, Chapel Hill, NC, USA
    J Neuroimmunol 130:32-45. 2002
    ..While the peripheral macrophages were far outnumbered by the resident microglia, their recruitment across the blood-brain barrier alludes to a potentially important role...
  14. ncbi Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis
    Melissa A Cosenza
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Pathol 12:442-55. 2002
    ..Because productively infected tissue macrophages serve as the major viral reservoir, these findings have important implications for AIDS...
  15. ncbi Functional defect of circulating regulatory CD4+ T cells in patients with Wegener's granulomatosis in remission
    Wayel H Abdulahad
    University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 56:2080-91. 2007
    ..The objective of this study was to test whether the frequency and/or function of Treg cells from WG patients in remission are disturbed...
  16. ncbi Increased resistin gene and protein expression in human abdominal adipose tissue
    Philip G McTernan
    Division of Medical Sciences, Department of Medicine, University of Birmingham, Birmingham, B15 2TH, UK
    J Clin Endocrinol Metab 87:2407. 2002
    ..In conclusion, this study confirms the expression of resistin in human adipose tissue and increased expression in abdominal fat, this suggests a potential role in linking central obesity to type 2 diabetes and/or cardiovascular disease...
  17. ncbi Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties
    Lisheng Wang
    Robarts Research Institute, Krembil Centre for Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    Immunity 21:31-41. 2004
    ....
  18. pmc Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    J Clin Invest 114:438-46. 2004
    ..Thus, our results demonstrate, we believe for the first time, that circulating fibrocytes contribute to the pathogenesis of pulmonary fibrosis...
  19. ncbi Increased circulating fibrocytes in asthma with chronic airflow obstruction
    Chun Hua Wang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, 199 Tun Hwa North Road, Taipei, Taiwan
    Am J Respir Crit Care Med 178:583-91. 2008
    ..We hypothesized that this effect may result from increased activity of circulating fibroblast-like progenitor cells (fibrocytes) that could home to the airway mucosal wall...
  20. ncbi Physiological migration of hematopoietic stem and progenitor cells
    D E Wright
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 294:1933-6. 2001
    ..These data demonstrate that HSCs rapidly and constitutively migrate through the blood and play a physiological role in, at least, the functional reengraftment of unconditioned bone marrow...
  21. ncbi Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody
    Carine Asselin-Paturel
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    J Immunol 171:6466-77. 2003
    ..The higher ability of 129Sv mice to produce IFN-alpha in vivo is related to a higher number of pDC, but also to a higher ability of pDC from 129Sv mice to produce IFN-alpha in vitro in response to viral stimulation...
  22. pmc Muscle-derived hematopoietic stem cells are hematopoietic in origin
    Shannon L McKinney-Freeman
    Department of Pediatrics, Center for Cell and Gene Therapy, BCM 505, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:1341-6. 2002
    ..Although CD45-negative cells were highly myogenic in vitro and in vivo, CD45-positive muscle-derived cells displayed only very limited myogenic activity and only in vivo...
  23. pmc A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
    Gesine Kogler
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Exp Med 200:123-35. 2004
    ..No tumor formation was observed in any of these animals...
  24. ncbi Lack of CD27-CD45RA-V gamma 9V delta 2+ T cell effectors in immunocompromised hosts and during active pulmonary tuberculosis
    Cristiana Gioia
    Laboratory of Clinical Pathology Immunopathology, Padiglione Del Vecchio, National Institute for Infectious Diseases, Lazzaro Spallanzani, Institute for Cancer Research and Treatment, Via Portuense 292, 00149 Rome, Italy
    J Immunol 168:1484-9. 2002
    ..These observations indicate that monitoring and boosting gammadelta T cell effectors could be clinically relevant both in immunocompromised hosts and during active tuberculosis disease...
  25. pmc CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
    K F Byth
    Department of Pathology, Cambridge University, United Kingdom
    J Exp Med 183:1707-18. 1996
    ..We conclude that CD45 is not required at any stage during the generation of mature peripheral B cells, however its loss reveals a previously unrecognized role for CD45 in the regulation of certain subpopulations of B cells...
  26. ncbi CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway
    S Lesage
    Institut de Recherches Cliniques de Montreal, Quebec, Canada
    J Immunol 159:4762-71. 1997
    ..We propose that during T cell development, CD45 ligation could induce the death of those immature thymocytes that do not fulfill the requirements for positive selection...
  27. ncbi Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude
    M Mittelbronn
    Institute of Brain Research, University of Tuebingen, Medical School, Calwer Strasse 3, 72076 Tuebingen, Germany
    Acta Neuropathol 101:249-55. 2001
    ..The brains showed no or a negligible vascular expression of MRP8 and MRP14. Information about the local microglia density in the normal human brain can serve as a reference for the evaluation of pathological microglial responses...
  28. pmc Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10162-72. 2006
    ..Taken together, the loss of HIV-specific CD4+ T cells is associated with a combination of an infection of CCR5+ CD127+ memory CD4+ T cells, possibly in GALT, and a high expression of the inhibitory receptor CTLA-4...
  29. ncbi Neural stem cells in the subventricular zone are a source of astrocytes and oligodendrocytes, but not microglia
    Steven W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Dev Neurosci 25:184-96. 2003
    ..Therefore, the microglia that reside in the SVZDL are immigrants from nonneural precursors...
  30. pmc The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells
    Lionel Franz Poulin
    Centre d immunologie de Marseille Luminy, Universite de la Mediterrannee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 204:3119-31. 2007
    ..Our results stress that the langerin(+) DC network is more complex than originally thought and have implications for the development of transcutaneous vaccines and the improvement of humanized mouse models...
  31. ncbi Measurement and modeling of human T cell kinetics
    Derek C Macallan
    Department of Infectious Diseases, St George s Hospital Medical School, London, GB
    Eur J Immunol 33:2316-26. 2003
    ..The new kinetic model fits the data closely and avoids the need to postulate a large external source of lymphocytes to maintain equilibrium...
  32. ncbi Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs
    Pierre Brawand
    Amgen Inc, Seattle, WA 98101, USA
    J Immunol 169:6711-9. 2002
    ..Thus, the in vitro generation of murine pDCs may serve as a useful tool to further investigate pDC biology as well as the potential role of these cells in viral immunity and other settings...
  33. ncbi Flow cytometric analysis of inflammatory cells in ischemic rat brain
    Marilena Campanella
    Schering Plough Research Institute, Milan, Italy
    Stroke 33:586-92. 2002
    ..However, this technique has not been applied to the study of cerebral ischemia inflammation. The aim of this study was to establish a flow cytometric method to measure inflammatory cells in ischemic brain...
  34. ncbi Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    R E Mebius
    Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Immunity 7:493-504. 1997
    ..Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture...
  35. pmc HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity
    Souheil Antoine Younes
    Departement de Microbiologie et Immunologie, Universite de Montreal, 2900 Edouard Montpetit Boulevard, Montreal H3T 1J4, Canada
    J Exp Med 198:1909-22. 2003
    ..Our data favor a model whereby competent HIV-specific Tcm continuously arise in small numbers but under persistent antigenemia are rapidly induced to differentiate into IFN-gamma only-producing cells that lack self-renewal capacity...
  36. ncbi CD45: new jobs for an old acquaintance
    J M Penninger
    Amgen Research Institute and Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, ON M5G 2C1, Canada
    Nat Immunol 2:389-96. 2001
    ..Thus, CD45 is moving rapidly back into the spotlight as a drug target and central regulator involved in differentiation of multiple hematopoietic cell lineages, autoimmunity and antiviral immunity...
  37. ncbi Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease
    C Kung
    Howard Hughes Medical Institute, St Louis, Missouri 63110, USA
    Nat Med 6:343-5. 2000
    ..Despite normal B-lymphocyte numbers, serum immunoglobulin levels decreased with age. Thus, CD45 deficiency in humans results in T- and B-lymphocyte dysfunction...
  38. ncbi Little evidence for developmental plasticity of adult hematopoietic stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 297:2256-9. 2002
    ..These data indicate that "transdifferentiation" of circulating HSCs and/or their progeny is an extremely rare event, if it occurs at all...
  39. ncbi CD4+CD25high regulatory cells in human peripheral blood
    C Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 167:1245-53. 2001
    ....
  40. ncbi IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    M Hara
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 166:3789-96. 2001
    ....
  41. ncbi Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes
    U D'Oro
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 162:1879-83. 1999
    ..These results support a model in which CD45 dephosphorylates both Tyr505 and Tyr394, the net effect in normal thymocytes being a decrease in enzymatic activity...
  42. pmc CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis
    Melissa A Cosenza-Nashat
    Department of Science, BMCC, City University of New York, New York, NY, USA
    Brain Pathol 16:256-65. 2006
    ..RO was low in control microglia, but increased in HIVE. RO was also localized to macrophages and CD8+ T cells. Targeting CD45 in vivo with isoform-specific antibodies remains a therapeutic option for neuroinflammatory diseases...
  43. ncbi CD45: a critical regulator of signaling thresholds in immune cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, 94143, USA
    Annu Rev Immunol 21:107-37. 2003
    ..Perturbation of this function may contribute to autoimmunity, immunodeficiency, and malignancy. Moreover, recent advances suggest that modulation of CD45 function can have therapeutic benefit in many disease states...
  44. ncbi CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory
    A Cossarizza
    Dipartimento di Scienze Biomediche, University of Modena, Italy
    Mech Ageing Dev 86:173-95. 1996
    ..Moreover, the data on centenarians suggest that they may represent a very selected population where a slowing of immunosenescence occurs...
  45. pmc B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    F Loder
    Department of Molecular Immunology, University of Freiburg, Germany
    J Exp Med 190:75-89. 1999
    ....
  46. pmc CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury
    Bethany B Moore
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Am J Pathol 166:675-84. 2005
    ..This is the first report describing expression of CCR2 on lung fibrocytes and demonstrating that CCR2 regulates both recruitment and activation of these cells after respiratory injury...
  47. ncbi Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    F Powrie
    DNAX Research Institute of Molecular and Cellular Biology Incorporated, Palo Alto, California 94040, USA
    Immunity 1:553-62. 1994
    ..Severe colitis was completely abrogated in mice treated systemically with rIL-10, but not with rIL-4...
  48. ncbi Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration
    Anna Polesskaya
    Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
    Cell 113:841-52. 2003
    ..Our data therefore suggest that mobilization of resident CD45(+) stem cells is an important factor in regeneration after injury and highlight the Wnt pathway as a potential therapeutic target for degenerative neuromuscular disease...
  49. ncbi Evidence that HIV budding in primary macrophages occurs through the exosome release pathway
    Deborah Greene Nguyen
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:52347-54. 2003
    ..These results strongly support the Trojan exosome hypothesis and its prediction that retroviral budding represents exploitation of a pre-existing cellular pathway of intercellular vesicle trafficking...
  50. ncbi Persistence of naive CD45RA+ regulatory T cells in adult life
    Nabila Seddiki
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW, Australia 2042
    Blood 107:2830-8. 2006
    ..Targeting naive TREGs in adults may offer new means of preventing and treating autoimmune disease...
  51. ncbi Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase
    N K Tonks
    Department of Biochemistry, University of Washington, Seattle 98195
    Biochemistry 27:8695-701. 1988
    ..No shift in CD45 or PTPase was observed following addition of a control IgG2a. On this basis, it is concluded that CD45 is a protein tyrosine phosphatase...
  52. pmc Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR
    M Streuli
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    EMBO J 9:2399-407. 1990
    ..It is suggested that this stretch of amino acids may be part of the catalytic center of PTPases...
  53. ncbi Productive HIV-2 infection in the brain is restricted to macrophages/microglia
    Andreas Mörner
    Department of Immunology and Molecular Pathology, University College London, UK
    AIDS 17:1451-5. 2003
    ..The aim of this study was to detect productive HIV-2 infection in the brain and investigate whether HIV-2 has an expanded tropism for brain cells in vivo, in comparison with HIV-1, which productively infects macrophages/microglia...
  54. ncbi Apoptosis of T cells mediated by galectin-1
    N L Perillo
    UCLA Department of Pathology and Laboratory Medicine, Los Angeles, California 90095 1732, USA
    Nature 378:736-9. 1995
    ..Induction of apoptosis by an endogenous mammalian lectin represents a new mechanism for regulating the immune response...
  55. ncbi CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta
    E L Deszo
    Departments of Animal Sciences and Pathology, University of Illinois at Urbana-Champaign, 61801, USA
    J Biol Chem 276:10212-7. 2001
    ..These findings suggest that CD45 is a critical regulator of monocytic cell development...
  56. pmc Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood
    Sonja Kimmig
    Department of Clinical Immunology, Deutsches Rheuma ForschungsZentrum Berlin, Schumannstrasse 21 22, 10117 Berlin, Germany
    J Exp Med 195:789-94. 2002
    ..We describe here the identification of peripherally expanded naive Th cells in human adult blood characterized by the loss of CD31 expression and a highly reduced TREC content...
  57. ncbi CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease
    Jun Tan
    Department of Psychiatry, Roskamp Institute, University of South Florida, 3515 E Fletcher Ave, Tampa, FL 33613, USA
    J Neuroimmunol 132:164-72. 2002
    ....
  58. pmc Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice
    T Benatar
    Wellesley Hospital Research Institute, University of Toronto, Canada
    J Exp Med 183:329-34. 1996
    ..While anti-Ig-induced mobilization of intracellular Ca2+ stores was normal, influx from extracellular sources was abrogated. This finding reveals a novel pathway of regulating B cell responses mediated by CD45...
  59. ncbi Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro
    D H Ng
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    J Biol Chem 271:1295-300. 1996
    ..In addition, this interaction occurred in the absence of any detectable tyrosine phosphorylation on CD45, suggesting a nonconventional SH2 domain interaction...
  60. ncbi Expansion of CD57 and CD62L-CD45RA+ CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection
    J Lieberman
    The Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    AIDS 13:891-9. 1999
    ..We examined whether other immunological parameters might influence the viral setpoint...
  61. ncbi PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45
    K L Anderson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:7637-42. 2001
    ..We conclude that CD45 is regulated differentially in myeloid and lymphoid cells and that sequences critical to direct myeloid expression include a PU.1 binding site upstream of the P1b transcriptional initiation site...
  62. ncbi Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt
    Hyeon Sook Suh
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:2712-9. 2005
    ..Ab-mediated activation of macrophage and microglial CD45 tyrosine phosphatase may have therapeutic implications for CNS inflammatory diseases...
  63. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  64. ncbi Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation
    J T Pingel
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 58:1055-65. 1989
    ..An L-CA+ revertant was obtained and the ability to proliferate in response to antigen and cross-linked CD3 was restored. These data indicate that L-CA is required for T cells to enter into cell cycle in response to antigen...
  65. ncbi MHC II+ CD45+ cells from synovium-rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitro
    Mahin Moghaddami
    Arthritis Research Laboratory, Hanson Institute for Medical Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Int Immunol 17:1103-15. 2005
    ..These results demonstrate that SRTs contain indeterminate cells that can differentiate into mature DCs in vitro in response to GM-CSF, plus mature synovial lining macrophages...
  66. ncbi Long-term allograft acceptance induced by single dose anti-leukocyte common antigen (RT7) antibody in the rat
    S Ko
    , Medizinische Hochschule Hannover, Germany
    Transplantation 71:1124-31. 2001
    ..Local immunoregulatory mechanisms seem to play a role for maintenance of long-term graft acceptance...
  67. ncbi CD45: direct and indirect government of immune regulation
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Immunol Lett 94:167-74. 2004
    ....
  68. ncbi TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis
    J J Bleesing
    Immunology Service, Warren G Magnuson Clinical Center, Bethesda, Maryland 20892, USA
    Clin Immunol 100:314-24. 2001
    ....
  69. pmc Antigen-capturing cells can masquerade as memory B cells
    Jennifer Bell
    Institute of Cell, Animal, and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Rd, Edinburgh EH9 3JT UK
    J Exp Med 197:1233-44. 2003
    ..We find no evidence of a B220- memory B cell population that is not explicable by antigen-capturing cells, and warn that care must be taken when using antigen-specificity or surface IgG as an indicator of B cell memory...
  70. ncbi Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms
    Zheng Xu
    Department of Medicine and The Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0795, USA
    Nat Immunol 3:764-71. 2002
    ..Our results not only demonstrate the biological significance of alternative splicing in the immune system, but also suggest a model for regulating RPTP dimerization and function...
  71. pmc Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia
    Mee Ohk Kim
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Virol 80:62-72. 2006
    ..alphaCD45RO-mediated inhibition of HIV-1 replication in microglia identifies the CD45 protein tyrosine phosphatase as a potential therapeutic target for HIV-1 infection/AIDS dementia...
  72. ncbi Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice
    P J Mee
    National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Eur J Immunol 29:2923-33. 1999
    ..Our results conclusively demonstrate that in double-positive thymocytes CD45 is a positive regulator of the TCR signals that drive thymic selection events...
  73. ncbi CD4+ CD45RB low-density cells from untreated mice prevent acute allograft rejection
    J D Davies
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 163:5353-7. 1999
    ..Unexpectedly, the CD45RB low-density cells prevent the CD45RBhigh expressing cells from causing rejection. These data suggest that the response to foreign tissue can be controlled in the same way as the response to self-tissue...
  74. ncbi Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase
    T Mustelin
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Eur J Immunol 25:942-6. 1995
    ..These findings suggest that CD45 plays an important role, direct or indirect, in the regulation of p70zap and its function in TcR/CD3 signaling...
  75. ncbi Transient RNA interference in hematopoietic progenitors with functional consequences
    Daniela M Oliveira
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 36:203-8. 2003
    ..These results demonstrate that transient transfection of siRNA to primary cells can have substantial functional consequences. This technology may be applicable to a variety of primary cell types...
  76. pmc The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
    A Saoudi
    Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 184:2393-8. 1996
    ....
  77. pmc Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    Joachim Lehmann
    Experimentelle Rheumatologie, Universitatsklinikum Charite, Humboldt Universitat, c o Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 99:13031-6. 2002
    ..Thus, the integrin alpha(E)beta(7) can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments...
  78. ncbi Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases
    Christophe Blanchetot
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands
    J Biol Chem 277:47263-9. 2002
    ..The RPTP-D2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs...
  79. ncbi A deletion in the gene encoding the CD45 antigen in a patient with SCID
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 166:1308-13. 2001
    ....
  80. ncbi The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct
    Veronique Baron
    Unité de Biologie Moléculaire du Gène, INSERM U277, Paris, France
    Immunity 18:193-204. 2003
    ..Altogether, these observations suggest that most effector memory T cells may not have derived from the central memory subset...
  81. ncbi Alterations in the level of CD45 surface expression affect the outcome of thymic selection
    V A Wallace
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    J Immunol 158:3205-14. 1997
    ..These data demonstrate that changes in the expression level of the receptor protein tyrosine phosphatase CD45 can alter thymic selection...
  82. pmc Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling
    Jing W Zhu
    Departments of Medicine and of Microbiology and Immunology, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, CA 94143, USA
    Immunity 28:183-96. 2008
    ....
  83. ncbi B220+ double-negative T cells suppress polyclonal T cell activation by a Fas-independent mechanism that involves inhibition of IL-2 production
    Abdel Rahim A Hamad
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Ross 659, Baltimore, MD 21205, USA
    J Immunol 171:2421-6. 2003
    ..These findings suggest that B220+ DN T cells may be involved in controlling autoreactive T cells in the absence of Fas-mediated peripheral tolerance...
  84. ncbi A novel dendritic cell subset involved in tumor immunosurveillance
    Julien Taieb
    ERM0208 INSERM, Faculté de Médecine Kremlin Bicêtre, Institut Gustave Roussy, Villejuif, France
    Nat Med 12:214-9. 2006
    ..In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response...
  85. pmc CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, 75015 Paris, France
    J Exp Med 204:2569-78. 2007
    ..1(+) cells upon activation in vitro or in vivo in a proliferation-dependent fashion. Our data suggest that the majority of CD11c(lo)B220(+) "IKDC-like" cells represent activated NK cells...
  86. ncbi Differentiation of human CD8(+) T cells from a memory to memory/effector phenotype
    Hiroko Tomiyama
    Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan
    J Immunol 168:5538-50. 2002
    ..The presence of a CD27(-)CD28(+) subset with a CCR5(+)CCR7(-) phenotype implies a specialized role for this subset in the differentiation of CD8(+) T cells...
  87. pmc Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners
    Fernando D Camargo
    Center for Cell and Gene Therapy, Baylor College of Medicinem Houston, Texas 77098, USA
    J Clin Invest 113:1266-70. 2004
    ..Our findings raise the possibility that differentiated myeloid cells may be useful for future therapeutic applications of in vivo cellular fusion...
  88. ncbi Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates
    Fernando D Camargo
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, BCM505, Houston, Texas 77030, USA
    Nat Med 9:1520-7. 2003
    ..Our results indicate that circulating myeloid cells, in response to inflammatory cues, migrate to regenerating skeletal muscle and stochastically incorporate into mature myofibers...
  89. pmc Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair
    Carrie Fathke
    Department of Surgery, Box 356410, University of Washington Medical Center, 1959 NE Pacific Street, Seattle 98195, USA
    Stem Cells 22:812-22. 2004
    ....
  90. ncbi B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    Jun Konishi
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Clin Cancer Res 10:5094-100. 2004
    ..Furthermore, we examined the correlation between B7-H1 expression on tumor cells and the number of tumor-infiltrating lymphocytes (TILs) or PD-1 expression on TILs...
  91. ncbi Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells
    Kristin Chadwick
    Robarts Research Institute, Stem Cell Biology and Regenerative Medicine, 100 Perth Dr, London, ON N6A 5K8, Canada
    Blood 102:906-15. 2003
    ....
  92. pmc Quantitation of HLA class II protein incorporated into human immunodeficiency type 1 virions purified by anti-CD45 immunoaffinity depletion of microvesicles
    Charles M Trubey
    Basic Research Program Research Technology Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    J Virol 77:12699-709. 2003
    ..Our observations demonstrate the utility of CD45 immunoaffinity-based approaches for producing highly purified retrovirus preparations for applications that would benefit from the use of virus that is essentially free of microvesicles...
  93. pmc The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 180:1886-94. 2008
    ..Absence of MyD88 in CD4(+)CD45Rb(high) cells results in defective T cell function, especially Th17 differentiation. These results suggest a role for TLR signaling by T cells in the development of inflammatory bowel disease...
  94. pmc Pax7 is necessary and sufficient for the myogenic specification of CD45+:Sca1+ stem cells from injured muscle
    Patrick Seale
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    PLoS Biol 2:E130. 2004
    ..Moreover, these experiments suggest that viral transduction of Pax7 is a potential therapeutic approach for the treatment of neuromuscular degenerative diseases...
  95. ncbi Differential expression of CD45 on canine microglial cells
    V M Stein
    Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany
    J Vet Med A Physiol Pathol Clin Med 54:314-20. 2007
    ..It appeared that dogs with high percentages of CD45+ suffered from long-lasting CNS disease with seizures. In future studies, the reason and consequences for upregulated CD45 in long-lasting CNS diseases has to be further evaluated...
  96. pmc The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase
    H Charbonneau
    Department of Biochemistry, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 85:7182-6. 1988
    ....
  97. ncbi Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein
    Marylène Fortin
    Division of Research and Development, PROCREA BioSciences, Inc, Montreal, Quebec, Canada
    J Immunol 168:6084-9. 2002
    ..Taken together, these results strongly suggest a role for the extracellular and/or the transmembrane portion of CD45 in apoptosis signaling, which contrasts with the previously reported functions for CD45 in T lymphocytes...
  98. ncbi A point mutation in PTPRC is associated with the development of multiple sclerosis
    M Jacobsen
    Department of Neurology, Philipps University, Marburg, Germany
    Nat Genet 26:495-9. 2000
    ..Our findings suggest an association of the mutation in PTPRC with the development of MS in some families...
  99. ncbi Persistent expansion of CD4+ effector memory T cells in Wegener's granulomatosis
    W H Abdulahad
    Department of Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 70:938-47. 2006
    ..Collectively, peripheral blood homeostasis of CD4+T cells is disturbed in R-WG with the persistent expansion of non-regulatory CD4+TEM cells. These cells might be involved in relapse and may constitute a target for therapy...
  100. ncbi Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment
    O Annacker
    Unité du Développement des Lymphocytes, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Institut Pasteur, Paris, France
    J Immunol 164:3573-80. 2000
    ....
  101. ncbi Liver-derived DEC205+B220+CD19- dendritic cells regulate T cell responses
    L Lu
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Immunol 166:7042-52. 2001
    ..In vivo administration of liver DEC205+B220+CD19- cells significantly prolonged the survival of vascularized cardiac allografts in an alloantigen-specific manner...

Research Grants68

  1. CD45 Pretargeted Radioimmunotherapy for AML
    Oliver W Press; Fiscal Year: 2013
    ....
  2. Alpha Radioimmunotherapy for Lymphoma Treatment
    BRENDA MARIE SANDMAIER; Fiscal Year: 2013
    ..We anticipate that the information from these studies will allow rapid translation of the optimized promising RIT strategy using 211At-anti-CD45 MAb into our clinical RIT HCT program for NHL. ..
  3. Bispecific Antibody Engineering for AML RIT
    Oliver W Press; Fiscal Year: 2013
    ..We anticipate rapid translation of the results of these preclinical experiments into our clinical RIT program for AML. ..
  4. THERAPY OF LYMPHOMA/LEUKEMIA WITH MONOCLONAL ANTIBODIES
    Oliver W Press; Fiscal Year: 2013
    ..We anticipate that the investigations described in this application will allow us to maximize the therapeutic efficacy and minimize the toxicity of myeloablative RIT for hematologic malignancies. ..
  5. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..These studies will provide fundamental insights into KC pathogensis and may provide a basis for therapy. ..
  6. MESANGIAL CELL IN DEVELOPMENT OF GLOMERULOSCLEROSIS
    Sharon Adler; Fiscal Year: 1992
    ..The experiments outlined utilize state of the art technologies in molecular biology and extracellular matrix biochemistry to probe the pathogenesis of glomerulosclerosis, a critical issue at the forefront of nephrology...
  7. GENETIC ANALYSIS OF REGULATION AND FUNCTION OF CD45
    William Raschke; Fiscal Year: 2002
    ..The roles of the extracellular domain, the cytoplasmic domain and critical functional sites will be evaluated in this manner. ..
  8. Radioimmunotherapy of CD20+ Lymphomas & CD45+Leukemias
    JOHN PAGEL; Fiscal Year: 2008
    ..of RIT using a two-step streptavidin(SA)-biotin pretargeting strategy to target the anti-CD20 and anti-CD45 antigens on the surface of NHL and AML tumor cells, respectively...
  9. Radioimmunotherapy of Acute Leukemia
    Eneida Nemecek; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. B220+DN Tcells in Mucosal Tolerance and Inflammation
    ABDEL HAMAD; Fiscal Year: 2005
    ..In addition, they lay the groundwork for the analysis of B220+ DN T cell in healthy individuals and IBD patients. ..
  11. Proapoptotic Therapy for B-cell Non Hodgkin's Lymphoma
    Ajay Gopal; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  12. OPTIMIZING RADIOIMMUNOTHERAPY FOR NON HODGKIN'S LYMPHOMA
    Ajay Gopal; Fiscal Year: 2005
    ..We anticipate that these interventions will ultimately enhance the prognosis for patients with relapsed lymphoma by increasing the response and survival rates, while simultaneously minimizing toxicities. ..
  13. B220+ DN alphabeta T cell as a novel immunoregulatory T*
    ABDEL HAMAD; Fiscal Year: 2005
    ..The findings generated by these studies will aid in characterizing a novel naturally occurring regulatory T cells and define their role in peripheral and mucosal tolerance. ..
  14. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..
  15. Lineage decision in blood stem and progenitor cells
    Koichi Akashi; Fiscal Year: 2007
    ..Thus, we hope these studies will help understand mechanistic effects of these transcription factors on lineage decision in normal and malignant hematopoietic development. ..
  16. Chronic Prostatitis Collaborative Research Network CPCRN
    J Nickel; Fiscal Year: 2007
    ..Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with CPPS in clinical studies and will be a valuable partner in the proposed CPCRN and UCPPSCG. ..
  17. Negative regulation of TCR-associated PTKs
    ROBERT RICKERT; Fiscal Year: 2007
    ..These issues are important for our understanding of the molecular machinery of T cell activation and the immune response. ..
  18. Synaptic change in cingulate cortex after amputation
    Min Zhuo; Fiscal Year: 2006
    ..This information will provide a potential neuronal basis for understanding phantom limb sensation and phantom pain. ..
  19. Joint degeneration: Somatic mosaic analysis in a transgenic mouse
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. PGE2 Regulation of Epithelial/Fibroblast Interactions
    Bethany Moore; Fiscal Year: 2006
    ..abstract_text> ..
  21. Biocontained ImageStream 100 Multispectral Imaging Cytometer
    Judy Lieberman; Fiscal Year: 2007
    ..It will guide efforts for developing effective vaccines and immunotherapies and drug therapies for infection and cancer. [unreadable] [unreadable] [unreadable]..
  22. CD40 Modulation of Abeta-Vaccine Immune Response
    Jun Tan; Fiscal Year: 2007
    ..abstract_text> ..
  23. Astatine-211 Conditioning for Nonmyeloablative Hematopoietic Stem Cell Allografts
    BRENDA MARIE SANDMAIER; Fiscal Year: 2010
    ..The final, and most important, studies will involve determining the quantity of 211At-labeled MAb required to obtain stable engraftment in HCT involvingDLA- haploidentical littermates. ..
  24. Cognitive Behavioral Stress Management for Chronic Fatigue Syndrome
    Michael Antoni; Fiscal Year: 2009
    ....
  25. Role of Eotaxin-3/CCL26 in Allergic Asthma
    Lisa Miller; Fiscal Year: 2008
    ..The identification of chemokines that promote allergic asthma is an important step in the future development of therapeutics to target specific molecules within the airways. [unreadable] [unreadable] [unreadable]..
  26. HIV-1 Transgenic Rat Develops Abnormal T Cells Subsets
    William Reid; Fiscal Year: 2007
    ..Our goals are to understand how expression of HIV gene products causes defects in the development or maintenance of T cell effector function in Tg rats and to identify the relevant viral gene. ..
  27. Early Immune Events in Childhood Asthma
    Lisa Miller; Fiscal Year: 2009
    ..abstract_text> ..
  28. Origin of HSC from Embryonic Stem Cells
    Elias Zambidis; Fiscal Year: 2008
    ..The success of these goals will lay the groundwork for characterizing human stem cells not available by any other means. ..
  29. Role of gp-340 in HIV Infection and Transmission
    Drew Weissman; Fiscal Year: 2008
    ....
  30. Cell survival and cell death in the auditory nerve
    Hainan Lang; Fiscal Year: 2008
    ..abstract_text> ..
  31. FACILITATING POSITIVE ADAPTATION TO BREAST CANCER
    MICHAEL HOWARD ANTONI; Fiscal Year: 2010
    ..abstract_text> ..
  32. Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial Cells
    Charles Wira; Fiscal Year: 2007
    ..These studies should provide the basis of knowledge essential for the development of more effective microbicides, therapeutic interventions, ..
  33. Targeting Vasculogenesis and Interstitial Hypertension in Neurofibromatosis Type1
    Ugur Ozerdem; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. Effect of Viral Escape on Memory T Cell Maturation
    RAFICK PIERRE SEKALY; Fiscal Year: 2006
    ..Overall, we will be able to assess the importance of Ag specific CD4+ memory T cells and of viral escape in the maintenance of persistence CTL response. [unreadable] [unreadable]..
  35. TH-1 BIAS IN RHEUMATOID ARTHRITIS
    Laurie Davis; Fiscal Year: 2003
    ..It is anticipated that the information obtained should provide important new insights into the regulatory influences on the differentiation of CD4+ memory effector cells in man. ..
  36. CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITIS
    J Nickel; Fiscal Year: 2003
    ..Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially. ..
  37. Genetic Risk Factors for Airflow Obstruction after HSCT
    Joan Clark; Fiscal Year: 2003
    ..Ultimately, this insight can be applied to understand inflammation and how it causes more common lung diseases. ..
  38. THE ROLE OF MEN IN FAMILY FORMATION AND PARENTING
    Renata Forste; Fiscal Year: 2001
    ..Overall, the primary aim of the study is to heighten understanding of the mechanisms underlying the role of men in nonmarital childbearing, as well as the early involvement of men with their children. ..
  39. Molecular mechanism of immune evasion by Yersinia pestis
    Tomas Mustelin; Fiscal Year: 2003
    ..This information, together with a specific YopH inhibitor that works in the same T cell activation model, will represent valuable progress towards the goal of designing a drug to combat plague mortality. ..
  40. Apoptosis and Immunity
    Judy Lieberman; Fiscal Year: 2002
    ..abstract_text> ..
  41. ENDOTHELIAL-DEPENDENT VASODILATATION IN PREECLAMPSIA
    Scott Kauma; Fiscal Year: 2003
    ..The K24 award will protect this candidates time and help him to mature into a senior investigator in OB/GYN. ..
  42. PATIENT ORIENTED RESEARCH IN CUTANEOUS ONCOLOGY
    Stuart Lessin; Fiscal Year: 2003
    ..Lessin to continue to participate in the ongoing departmental and institutional POR programs and serve as a role model and mentor for young investigators in POR at the University of Pennsylvania. ..
  43. ANTILEUKEMIA ACTIVITY OF PERILLYL ALCOHOL
    Steven Clark; Fiscal Year: 2003
    ..abstract_text> ..
  44. SEROTONERGIC REGULATION OF SENSORY TRANSMISSION
    Min Zhuo; Fiscal Year: 2002
    ..The proposed studies will generate synaptic mechanisms for fast glutamatergic transmission as well as 5-HT regulation in the spinal cord. This information will be important for understanding central pain transmission and modulation. ..
  45. FASL IN PREECLAMPSIA AND IMMUNOTOLERANCE TO THE FETUS
    Scott Kauma; Fiscal Year: 2002
    ..These studies will significantly advance our understanding of the mechanisms involved in the pathogenesis of preeclampsia and provide new rationales for the treatment of this disease. ..
  46. Gene therapy for treatment of craniofacial dysplasia
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..Completion of this study will aid in the development of novel therapies for the management of genetic disorders. ..
  47. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2004
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. ..
  48. Cell immune responses in SIV-infected sooty mangabeys
    Amitinder Kaur; Fiscal Year: 2004
    ..abstract_text> ..
  49. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  50. Regulation of the tumor suppressor PTEN
    Tomas Mustelin; Fiscal Year: 2006
    ..The possible crosstalk between two pathways of programmed cell death (PTEN and Egr-1) may be highly relevant for the understanding and eventual treatment of a large number of human cancers. ..
  51. INTRACELLULAR PTPASES AND T CELL ACTIVATION
    Tomas Mustelin; Fiscal Year: 2001
    ..This information, in turn, is crucial for the study of deregulated and malignant proliferation of cells, e.g., in T cell lymphomas and other malignant diseases. ..
  52. ACTIVITY OF LYMPHOTACTIN IN CHILDHOOD MALIGNANCY
    Malcolm Brenner; Fiscal Year: 2001
    ..The results obtained with neuroblastoma cells should be generally applicable with other human cancers. ..
  53. BONE MARROW AS A SOURCE FOR PANCREATIC STEM CELLS
    Bryon Petersen; Fiscal Year: 2002
    ..The same data could potentially provide a valuable resource for future tissue engineering and cell therapy technique interventions in pancreatic regeneration. ..
  54. Characterization of human hematopoietic precursor cells
    Christopher Hogan; Fiscal Year: 2005
    ..This would be an enormous gain for patients enrolled in future clinical trials that will rely on stem cell therapies. ..
  55. PRE-CLINICAL COMBINATION CHEMO- AND RADIOANTIBODY THERAP
    Rhona Stein; Fiscal Year: 2005
    ..2) Therapy-induced changes in marker expression post therapy can be identified clinically in small samples of circulating tumor cells. ..
  56. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2005
    ....
  57. Stem cell homing/engraftment in lung injury and repair
    Zea Borok; Fiscal Year: 2004
    ..Identification of an adult human stem cell population with the ability to generate differentiated cell types would offers extraordinary therapeutic potential for repair of the lungs (and other organs) following injury. ..
  58. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2007
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. [unreadable] [unreadable]..
  59. Role of CD45 in Hematopoiesis and Lymphomagenesis
    Michelle Hermiston; Fiscal Year: 2005
    ..These studies should provide important insights into the links between immune regulation, autoimmunity, and lymphoid malignancies as well as improve our understanding of the mechanisms governing immune surveillance. ..
  60. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2008
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. [unreadable] [unreadable] [unreadable] [unreadable]..
  61. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  62. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
    ..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
  63. Int'l Society for Trace Elements Research in Humans
    Harold Sandstead; Fiscal Year: 2005
    ....
  64. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  65. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  66. TCR Genes and HIV-Specific Cytotoxic T-lymphocytes
    Spyros Kalams; Fiscal Year: 2006
    ..4) Determine whether the generation of a diverse TCR repertoire contains populations of high-avidity CTL that come to dominate the population of CTL during chronic infection and mediate control of HIV- 1 replication. ..