cd45 antigens

Summary

Summary: High-molecular weight glycoproteins uniquely expressed on the surface of all leukocytes and their hemopoietic progenitors. The CD45 family consists of multiple members that are all products of a single gene. CD45 expression is necessary for signaling through the T-cell receptor.

Top Publications

  1. ncbi Control of intestinal inflammation by regulatory T cells
    B Singh
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 182:190-200. 2001
  2. ncbi Increased circulating fibrocytes in asthma with chronic airflow obstruction
    Chun Hua Wang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, 199 Tun Hwa North Road, Taipei, Taiwan
    Am J Respir Crit Care Med 178:583-91. 2008
  3. ncbi The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase
    H Charbonneau
    Department of Biochemistry, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 85:7182-6. 1988
  4. ncbi IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    M Hara
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 166:3789-96. 2001
  5. ncbi CD4+CD25high regulatory cells in human peripheral blood
    C Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 167:1245-53. 2001
  6. ncbi Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
  7. ncbi A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
    Gesine Kogler
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Exp Med 200:123-35. 2004
  8. ncbi Muscle-derived hematopoietic stem cells are hematopoietic in origin
    Shannon L McKinney-Freeman
    Department of Pediatrics, Center for Cell and Gene Therapy, BCM 505, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:1341-6. 2002
  9. ncbi Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR
    M Streuli
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    EMBO J 9:2399-407. 1990
  10. ncbi Alterations in the level of CD45 surface expression affect the outcome of thymic selection
    V A Wallace
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    J Immunol 158:3205-14. 1997

Research Grants

  1. Bispecific Antibody Engineering for AML RIT
    OLIVER W contact PRESS; Fiscal Year: 2010
  2. CD45 Pretargeted Radioimmunotherapy for AML
    Oliver W Press; Fiscal Year: 2010
  3. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
  4. GENETIC ANALYSIS OF REGULATION AND FUNCTION OF CD45
    William Raschke; Fiscal Year: 2002
  5. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2010
  6. Radioimmunotherapy of CD20+ Lymphomas & CD45+Leukemias
    JOHN PAGEL; Fiscal Year: 2007
  7. OPTIMIZING RADIOIMMUNOTHERAPY FOR NON HODGKIN'S LYMPHOMA
    Ajay Gopal; Fiscal Year: 2005
  8. Proapoptotic Therapy for B-cell Non Hodgkin's Lymphoma
    Ajay Gopal; Fiscal Year: 2007
  9. Radioimmunotherapy of Acute Leukemia
    Eneida Nemecek; Fiscal Year: 2007
  10. B220+ DN alphabeta T cell as a novel immunoregulatory T*
    ABDEL HAMAD; Fiscal Year: 2005

Detail Information

Publications184 found, 100 shown here

  1. ncbi Control of intestinal inflammation by regulatory T cells
    B Singh
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 182:190-200. 2001
    ....
  2. ncbi Increased circulating fibrocytes in asthma with chronic airflow obstruction
    Chun Hua Wang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, 199 Tun Hwa North Road, Taipei, Taiwan
    Am J Respir Crit Care Med 178:583-91. 2008
    ..We hypothesized that this effect may result from increased activity of circulating fibroblast-like progenitor cells (fibrocytes) that could home to the airway mucosal wall...
  3. ncbi The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase
    H Charbonneau
    Department of Biochemistry, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 85:7182-6. 1988
    ....
  4. ncbi IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    M Hara
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 166:3789-96. 2001
    ....
  5. ncbi CD4+CD25high regulatory cells in human peripheral blood
    C Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 167:1245-53. 2001
    ....
  6. ncbi Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  7. ncbi A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
    Gesine Kogler
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Exp Med 200:123-35. 2004
    ..No tumor formation was observed in any of these animals...
  8. ncbi Muscle-derived hematopoietic stem cells are hematopoietic in origin
    Shannon L McKinney-Freeman
    Department of Pediatrics, Center for Cell and Gene Therapy, BCM 505, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:1341-6. 2002
    ..Although CD45-negative cells were highly myogenic in vitro and in vivo, CD45-positive muscle-derived cells displayed only very limited myogenic activity and only in vivo...
  9. ncbi Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR
    M Streuli
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    EMBO J 9:2399-407. 1990
    ..It is suggested that this stretch of amino acids may be part of the catalytic center of PTPases...
  10. ncbi Alterations in the level of CD45 surface expression affect the outcome of thymic selection
    V A Wallace
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    J Immunol 158:3205-14. 1997
    ..These data demonstrate that changes in the expression level of the receptor protein tyrosine phosphatase CD45 can alter thymic selection...
  11. ncbi CD4+ CD45RB low-density cells from untreated mice prevent acute allograft rejection
    J D Davies
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 163:5353-7. 1999
    ..Unexpectedly, the CD45RB low-density cells prevent the CD45RBhigh expressing cells from causing rejection. These data suggest that the response to foreign tissue can be controlled in the same way as the response to self-tissue...
  12. ncbi The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
    A Saoudi
    Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 184:2393-8. 1996
    ....
  13. ncbi CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
    K F Byth
    Department of Pathology, Cambridge University, United Kingdom
    J Exp Med 183:1707-18. 1996
    ..We conclude that CD45 is not required at any stage during the generation of mature peripheral B cells, however its loss reveals a previously unrecognized role for CD45 in the regulation of certain subpopulations of B cells...
  14. ncbi Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice
    P J Mee
    National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Eur J Immunol 29:2923-33. 1999
    ..Our results conclusively demonstrate that in double-positive thymocytes CD45 is a positive regulator of the TCR signals that drive thymic selection events...
  15. ncbi Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease
    C Kung
    Howard Hughes Medical Institute, St Louis, Missouri 63110, USA
    Nat Med 6:343-5. 2000
    ..Despite normal B-lymphocyte numbers, serum immunoglobulin levels decreased with age. Thus, CD45 deficiency in humans results in T- and B-lymphocyte dysfunction...
  16. ncbi A deletion in the gene encoding the CD45 antigen in a patient with SCID
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 166:1308-13. 2001
    ....
  17. ncbi Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    Joachim Lehmann
    Experimentelle Rheumatologie, Universitatsklinikum Charite, Humboldt Universitat, c o Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 99:13031-6. 2002
    ..Thus, the integrin alpha(E)beta(7) can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments...
  18. ncbi Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases
    Christophe Blanchetot
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands
    J Biol Chem 277:47263-9. 2002
    ..The RPTP-D2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs...
  19. ncbi The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct
    Veronique Baron
    Unité de Biologie Moléculaire du Gène, INSERM U277, Paris, France
    Immunity 18:193-204. 2003
    ..Altogether, these observations suggest that most effector memory T cells may not have derived from the central memory subset...
  20. ncbi Transient RNA interference in hematopoietic progenitors with functional consequences
    Daniela M Oliveira
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 36:203-8. 2003
    ..These results demonstrate that transient transfection of siRNA to primary cells can have substantial functional consequences. This technology may be applicable to a variety of primary cell types...
  21. ncbi Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase
    T Mustelin
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Eur J Immunol 25:942-6. 1995
    ..These findings suggest that CD45 plays an important role, direct or indirect, in the regulation of p70zap and its function in TcR/CD3 signaling...
  22. ncbi Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia
    Mee-Ohk Kim
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Virol 80:62-72. 2006
    ..alphaCD45RO-mediated inhibition of HIV-1 replication in microglia identifies the CD45 protein tyrosine phosphatase as a potential therapeutic target for HIV-1 infection/AIDS dementia...
  23. ncbi Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase
    N K Tonks
    Department of Biochemistry, University of Washington, Seattle 98195
    Biochemistry 27:8695-701. 1988
    ..No shift in CD45 or PTPase was observed following addition of a control IgG2a. On this basis, it is concluded that CD45 is a protein tyrosine phosphatase...
  24. ncbi Increased resistin gene and protein expression in human abdominal adipose tissue
    Philip G McTernan
    Division of Medical Sciences, Department of Medicine, University of Birmingham, Birmingham, B15 2TH, UK
    J Clin Endocrinol Metab 87:2407. 2002
    ..In conclusion, this study confirms the expression of resistin in human adipose tissue and increased expression in abdominal fat, this suggests a potential role in linking central obesity to type 2 diabetes and/or cardiovascular disease...
  25. ncbi Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  26. ncbi Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair
    Carrie Fathke
    Department of Surgery, Box 356410, University of Washington Medical Center, 1959 NE Pacific Street, Seattle 98195, USA
    Stem Cells 22:812-22. 2004
    ....
  27. ncbi B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    Jun Konishi
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Clin Cancer Res 10:5094-100. 2004
    ..Furthermore, we examined the correlation between B7-H1 expression on tumor cells and the number of tumor-infiltrating lymphocytes (TILs) or PD-1 expression on TILs...
  28. ncbi Apoptosis of T cells mediated by galectin-1
    N L Perillo
    UCLA Department of Pathology and Laboratory Medicine, Los Angeles, California 90095 1732, USA
    Nature 378:736-9. 1995
    ..Induction of apoptosis by an endogenous mammalian lectin represents a new mechanism for regulating the immune response...
  29. ncbi Persistent expansion of CD4+ effector memory T cells in Wegener's granulomatosis
    W H Abdulahad
    Department of Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 70:938-47. 2006
    ..Collectively, peripheral blood homeostasis of CD4+T cells is disturbed in R-WG with the persistent expansion of non-regulatory CD4+TEM cells. These cells might be involved in relapse and may constitute a target for therapy...
  30. ncbi Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood
    Sonja Kimmig
    Department of Clinical Immunology, Deutsches Rheuma-Forschungszentrum Berlin, Schumannstrasse 21/22, 10117 Berlin, Germany
    J Exp Med 195:789-94. 2002
    ..We describe here the identification of peripherally expanded naive Th cells in human adult blood characterized by the loss of CD31 expression and a highly reduced TREC content...
  31. ncbi Functional defect of circulating regulatory CD4+ T cells in patients with Wegener's granulomatosis in remission
    Wayel H Abdulahad
    University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 56:2080-91. 2007
    ..The objective of this study was to test whether the frequency and/or function of Treg cells from WG patients in remission are disturbed...
  32. ncbi Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells
    Kristin Chadwick
    Robarts Research Institute, Stem Cell Biology and Regenerative Medicine, 100 Perth Dr, London, ON N6A 5K8, Canada
    Blood 102:906-15. 2003
    ....
  33. ncbi Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy
    Shujuan Liu
    Surgery Branch, National Cancer Institute (NCI, Bethesda, Maryland 20892-1502, USA
    J Immunother (1997) 29:284-93. 2006
    ....
  34. ncbi CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis
    Melissa A Cosenza-Nashat
    Department of Science, BMCC, City University of New York, New York, NY, USA
    Brain Pathol 16:256-65. 2006
    ..RO was low in control microglia, but increased in HIVE. RO was also localized to macrophages and CD8+ T cells. Targeting CD45 in vivo with isoform-specific antibodies remains a therapeutic option for neuroinflammatory diseases...
  35. ncbi Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development
    A Kumanogoh
    Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Japan
    J Immunol 166:353-60. 2001
    ..Collectively, our results indicate that CD40-CD40L interactions contribute to negative regulation of T cell autoreactivity and that defective interactions can lead to autoimmunity...
  36. ncbi Functional maturation of CD4+CD25+CTLA4+CD45RA+ T regulatory cells in human neonatal T cell responses to environmental antigens/allergens
    Catherine A Thornton
    School of Medicine, University of Wales, Swansea, United Kingdom
    J Immunol 173:3084-92. 2004
    ....
  37. ncbi Chemotactically-induced redistribution of CD43 as related to polarity and locomotion of human polymorphonuclear leucocytes
    A Dehghani Zadeh
    Institute of Pathology, University of Bern, 3010 Bern, Switzerland
    Biol Cell 95:265-73. 2003
    ..Our data show that anterior pseudopod formation, rather than capping of CD43 at the uropod or the position of the uropod determines the direction of locomotion...
  38. ncbi Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates
    Fernando D Camargo
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, BCM505, Houston, Texas 77030, USA
    Nat Med 9:1520-7. 2003
    ..Our results indicate that circulating myeloid cells, in response to inflammatory cues, migrate to regenerating skeletal muscle and stochastically incorporate into mature myofibers...
  39. ncbi Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms
    Zheng Xu
    Department of Medicine and The Howard Hughes Medical Institute, University of California, San Francisco, CA 94143-0795, USA
    Nat Immunol 3:764-71. 2002
    ..Our results not only demonstrate the biological significance of alternative splicing in the immune system, but also suggest a model for regulating RPTP dimerization and function...
  40. ncbi Quantitation of HLA class II protein incorporated into human immunodeficiency type 1 virions purified by anti-CD45 immunoaffinity depletion of microvesicles
    Charles M Trubey
    Basic Research Program. Research Technology Program, SAIC-Frederick, Inc, National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, USA
    J Virol 77:12699-709. 2003
    ..Our observations demonstrate the utility of CD45 immunoaffinity-based approaches for producing highly purified retrovirus preparations for applications that would benefit from the use of virus that is essentially free of microvesicles...
  41. ncbi HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity
    Souheil-Antoine Younes
    , , 2900 Edouard-Montpetit Boulevard, , Canada
    J Exp Med 198:1909-22. 2003
    ..Our data favor a model whereby competent HIV-specific Tcm continuously arise in small numbers but under persistent antigenemia are rapidly induced to differentiate into IFN-gamma only-producing cells that lack self-renewal capacity...
  42. ncbi Mature CD8(+) T lymphocyte response to viral infection during fetal life
    Arnaud Marchant
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Invest 111:1747-55. 2003
    ..The finding of a mature and functional CD8(+) T cell response to HCMV suggests that the machinery required to prime such responses is in place during fetal life and could be used to immunize newborns against viral pathogens...
  43. ncbi Measurement and modeling of human T cell kinetics
    Derek C Macallan
    Department of Infectious Diseases, St George s Hospital Medical School, London, GB
    Eur J Immunol 33:2316-26. 2003
    ..The new kinetic model fits the data closely and avoids the need to postulate a large external source of lymphocytes to maintain equilibrium...
  44. ncbi Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    Victor Appay
    MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Med 8:379-85. 2002
    ..These findings challenge the current definitions of memory and effector subsets in humans, and suggest that ascribing effector and memory functions to subsets with different differentiation phenotypes is no longer appropriate...
  45. ncbi Neural stem cells in the subventricular zone are a source of astrocytes and oligodendrocytes, but not microglia
    Steven W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Dev Neurosci 25:184-96. 2003
    ..Therefore, the microglia that reside in the SVZDL are immigrants from nonneural precursors...
  46. ncbi Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10162-72. 2006
    ..Taken together, the loss of HIV-specific CD4+ T cells is associated with a combination of an infection of CCR5+ CD127+ memory CD4+ T cells, possibly in GALT, and a high expression of the inhibitory receptor CTLA-4...
  47. ncbi Physiological migration of hematopoietic stem and progenitor cells
    D E Wright
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 294:1933-6. 2001
    ..These data demonstrate that HSCs rapidly and constitutively migrate through the blood and play a physiological role in, at least, the functional reengraftment of unconditioned bone marrow...
  48. ncbi Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors
    Meredith O'Keeffe
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 101:1453-9. 2003
    ..These findings indicate the close relationship between human and mouse DCs, provided cells are obtained directly from equivalent source materials...
  49. ncbi New insights into the transmembrane protein tyrosine phosphatase CD45
    T Sasaki
    Department of Pharmacology, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, 113 8613, Tokyo, Japan
    Int J Biochem Cell Biol 33:1041-6. 2001
    ..Modulation of CD45 splice variants provides a unique opportunity to design drugs that turn off or turn on antigen and cytokine receptor signaling in cancer, transplantation or autoimmunity..
  50. ncbi Evidence that HIV budding in primary macrophages occurs through the exosome release pathway
    Deborah Greene Nguyen
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:52347-54. 2003
    ..These results strongly support the Trojan exosome hypothesis and its prediction that retroviral budding represents exploitation of a pre-existing cellular pathway of intercellular vesicle trafficking...
  51. ncbi A quasi-monoclonal mouse
    M Cascalho
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0670, USA
    Science 272:1649-52. 1996
    ..Thus, neither network interactions nor random activation of a small fraction of the B cell population can account for serum Ig concentrations...
  52. ncbi Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    R E Mebius
    Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Immunity 7:493-504. 1997
    ..Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture...
  53. ncbi Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties
    Lisheng Wang
    Robarts Research Institute, Krembil Centre for Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    Immunity 21:31-41. 2004
    ....
  54. ncbi Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma
    J P Lamb
    Dept of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, 6009 Nedlands, WA, Australia
    Eur Respir J 26:265-70. 2005
    ..It is possible that survival signals may be received before cells migrate into the interstitium of the inner airway wall...
  55. ncbi Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells
    Iiro Rajantie
    Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Blood 104:2084-6. 2004
    ..Thus, the major contribution of the BM to angiogenic processes is not endothelial, but may come from progenitors for periendothelial vascular mural and hematopoietic effector cells...
  56. ncbi Identification and analysis of in vitro cultured CD45-positive cells capable of multi-lineage differentiation
    Ian Rogers
    Department of Obstetrics and Gynaecology, Rm 876 Samuel Lunenfeld Research Institute, Mount Sinai Hospital and the University of Toronto, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
    Exp Cell Res 313:1839-52. 2007
    ..Clonal cell analysis determined that the culture period caused a broadening in the differentiation potential of the starting population...
  57. ncbi Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt
    Hyeon-Sook Suh
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:2712-9. 2005
    ..Ab-mediated activation of macrophage and microglial CD45 tyrosine phosphatase may have therapeutic implications for CNS inflammatory diseases...
  58. ncbi Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation
    Jackie Felberg
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 279:3455-62. 2004
    ..This demonstrates a role for CD45-D2 in binding substrate and identifies the SD10 region in Lck as a novel site involved in substrate recognition...
  59. ncbi Generation and characterization of novel stromal specific antibodies
    Sapna Halder
    Prostate Cancer Research Centre, Institute of Urology 3rd floor, University College London, UK
    Cell Res 15:739-44. 2005
    ..A fibroblast-specific antibody that did not also identify vessels was not generated. Examples of each reactivity pattern are discussed...
  60. ncbi The accumulation of B220+ CD4- CD8- (DN) T cells in C3H-lpr/lpr mice is not accelerated by the stimulation of CD8+ T cells or B220+ DN T cells with staphylococcal enterotoxin B and occurs independently of V beta 8+ T cells
    T Giese
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int Immunol 7:1213-23. 1995
    ..In contrast to previous reports, chronic elimination of V beta 8+ T cells had no effect on the accumulation of B220+ DN T cells.(ABSTRACT TRUNCATED AT 400 WORDS)..
  61. ncbi Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
    J G Cyster
    Department of Microbiology and Immunology, Program in Immunology, Stanford University School of Medicine, California 94305, USA
    Nature 381:325-8. 1996
    ....
  62. ncbi A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential
    Gina Balciunaite
    Developmental and Molecular Immunology, Center for Biomedicine Department of Clinical and Biological Sciences (DKBW, University of Basel, Basel, Switzerland
    Eur J Immunol 35:2019-30. 2005
    ..The relationship between B220+ CD117+ CD19- NK1.1- cells of wild-type mice and other multi-lineage BM progenitors is discussed...
  63. ncbi A peripheral circulating compartment of natural naive CD4 Tregs
    Danila Valmori
    Ludwig Institute Clinical Trial Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Clin Invest 115:1953-62. 2005
    ..The definition of this subset has important implications for the analysis of human naturally occurring Tregs and for their targeting in therapeutic immune interventions...
  64. ncbi Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr
    T Giese
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    J Immunol 149:3097-106. 1992
    ..By comparison, C3H-lpr DN cells displayed some potentially significant differences in V beta 6 and V beta 9 expression from CD4+B220- and CD8+ T cells.(ABSTRACT TRUNCATED AT 400 WORDS)..
  65. ncbi Evaluation of a simplified dual-platform flow cytometric method for measurement of lymphocyte subsets and T-cell maturation phenotypes in the population of Nouna, Burkina Faso
    T Bohler
    Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Clin Vaccine Immunol 14:775-81. 2007
    ..Among CD8(bright) lymphocytes, 3% +/- 2% had a central memory phenotype, 27% +/- 13% were naïve, 37% +/- 13% had an effector memory phenotype, and 34% +/- 12% were terminally differentiated effector memory cells expressing CD45RA...
  66. ncbi Development of gammadelta thymocyte subsets during prenatal and postnatal ontogeny
    Marek Sinkora
    Department of Immunology and Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, , Czech Republic
    Immunology 115:544-55. 2005
    ..We propose that one subset acquires CD8alphaalpha in the thymus while the second acquires CD8alphaalpha as a result of stimulation in the periphery...
  67. ncbi Phenotypic and molecular characterization of CD103+ CD4+ T cells in bronchoalveolar lavage from patients with interstitial lung diseases
    Ruedi K Braun
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Cytometry B Clin Cytom 54:19-27. 2003
    ..The integrin CD103 is preferentially expressed on intraepithelial T lymphocytes, and cells expressing this integrin may play a regulatory role in the microenvironment of the epithelial cell layer...
  68. ncbi Characterization of HLA DR2 and DQ8 transgenic mouse with a new engineered mouse class II deletion, which lacks all endogenous class II genes
    S Cheng
    Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Autoimmun 21:195-9. 2003
    ..Therefore, this new class of HLA transgenic mice is the first to be completely "humanized" in their MHC class II genes and will be an invaluable mouse model for human MHC class II associated autoimmune diseases...
  69. ncbi CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism
    Takatoku Oida
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:2516-22. 2003
    ..The regulatory function of CD25(-)LAP(+) cells was abrogated in vivo by anti-TGF-beta mAb. These results identify a new TGF-beta-dependent regulatory CD4(+) T cell phenotype that is CD25(-) and LAP(+)...
  70. ncbi Association of Graves' disease and prevalence of circulating IFN-gamma-producing CD28(-) T cells
    Zhiping Sun
    Medical Biotechnology Institute, Soochow University, 48 Renmin Road, Suzhou 215007, China
    J Clin Immunol 28:464-72. 2008
    ..Peripheral blood CD4(+) and CD8(+) T-cell subsets lacking surface CD28 have been suggested to predispose patients to immune-mediated disorders...
  71. ncbi A pool of central memory-like CD4 T cells contains effector memory precursors
    J Magarian Blander
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520, USA
    J Immunol 170:2940-8. 2003
    ..Having these properties, the L51S TCR transgenic memory CD4 T cells cannot be classified as either strict central memory or effector memory, but, rather, as a pool of memory T cells containing effector memory precursors...
  72. ncbi Circulating CD4+CD25+ T regulatory and natural killer T cells in patients with myasthenia gravis: a flow cytometry study
    A Battaglia
    Department of Oncological Gynecology, Catholic University, Roma, Italy
    J Biol Regul Homeost Agents 19:54-62. 2005
    ..Immunomagnetically purified CD4+CD25+ cells from MG, healthy subjects and cancer patients were anergic and suppressed the proliferative response of other T cells...
  73. ncbi Superantigen-induced regulatory T cells display different suppressive functions in the presence or absence of natural CD4+CD25+ regulatory T cells in vivo
    Susanna Grundström
    Active Biotech Research AB, Lund, Sweden
    J Immunol 170:5008-17. 2003
    ....
  74. ncbi Cytometric analysis of BAL T cells labeled with a standardized antibody cocktail correlates with immunohistochemical staining
    Patricia A Smith
    Pulmonary Division, Indiana University School of Medicine, Indianapolis, 46202, USA
    Cytometry B Clin Cytom 70:170-8. 2006
    ....
  75. ncbi Two-signal blockade with anti-CD45RB and anti-CD154 monoclonal antibodies inhibits graft rejection via CD4-dependent mechanisms in allogeneic skin transplantation
    Eun Young Kim
    Transplantation Research Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
    Exp Mol Med 38:284-94. 2006
    ..In addition, results of IL-4 and IL-10 production were also showed CD4-dependence. Therefore, the two- signal blockade is accompanied by CD4-dependent mechanisms in allogeneic skin transplantation...
  76. ncbi High levels of Fas ligand and MHC class II in the absence of CD80 or CD86 expression and a decreased CD4+ T cell Infiltration, enables murine skin tumours to progress
    Scott N Byrne
    Department of Medicine Dermatology, Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital at the University of Sydney, 2006 Sydney, NSW, Australia
    Cancer Immunol Immunother 52:396-402. 2003
    ..This implies that tumours may induce anergy in CD4(+) T cells via MHC II antigen presentation in the absence of costimulation. To ensure escape from the immune system, tumours may then kill these T cells via a FasL-dependent mechanism...
  77. ncbi Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells
    Clare Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, NRB 641, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Clin Immunol 115:10-8. 2005
    ..With this system in place, we are poised to dissect the potential heterogeneity of mechanisms employed by highly specific subpopulations of CD4+ CD25+ cells...
  78. ncbi Identification and characterization of intestinal Peyer's patch interferon-alpha producing (plasmacytoid) dendritic cells
    Antonino Castellaneta
    Department of Surgery, the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hum Immunol 65:104-13. 2004
    ..This novel DC subset may play important roles in innate and adaptive immune responses of the gut and in the regulation of mucosal immune reactions...
  79. ncbi In vitro study of the long-term effects of post-traumatic splenectomy on cellular immunity
    M Karakantza
    Laboratory Haematology and Transfusion Medicine, Medical School, University of Patras, Patras, Greece
    Scand J Immunol 59:209-19. 2004
    ..In addition, changes in the profile of primed CD4+ T cells with time may be clinically relevant to relapses in autoimmune thrombocytopenia after splenectomy...
  80. ncbi Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models
    P Maerten
    Laboratory of Experimental Immunology, University Hospital of Leuven, Belgium
    Clin Exp Immunol 135:310-7. 2004
    ..In view of the divergent effects of IL-18 neutralization in the two different murine colitis models, it is unlikely that IL-18 is at the top of this cascade...
  81. ncbi Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo
    Lou Ann Yi
    Division of Hematology and Medical Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Int Immunol 16:539-47. 2004
    ..Elucidating the biochemical pathways downstream of Y201 will be important for a full understanding of the molecular basis for CTLA-4 function...
  82. ncbi Regulation of chronic colitis in athymic nu/nu (nude) mice
    F Stephen Laroux
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, 1501 Kings Highway, LA 71130, USA
    Int Immunol 16:77-89. 2004
    ..In addition, our data demonstrate that suppression of disease may be due to polarization of naive CD4(+) cells toward a non-pathogenic and/or regulatory phenotype...
  83. ncbi Limited long-term naive CD4+ T cell reconstitution in patients experiencing viral load rebounds during HAART
    H Choremi-Papadopoulou
    Department of Immunology, Laiko General Hospital, Athens, Greece
    J Med Virol 73:235-43. 2004
    ..In conclusion, full responders have a stronger long-term naive CD4(+) T cell subset reconstitution than partial responders...
  84. ncbi IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine
    Karen G Hogg
    Department of Biology (Area 5, PO Box 373, University of York, York YO10 5YW, UK
    Int Immunol 15:1451-9. 2003
    ....
  85. ncbi Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    D C Thomis
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 270:794-7. 1995
    ..These data demonstrate that Jak3 is critical for the progression of B cell development in the bone marrow and for the functional competence of mature T cells...
  86. ncbi Abnormalities in the T and NK lymphocyte phenotype in patients with Nijmegen breakage syndrome
    J Michałkiewicz
    Department of Microbiology and Immunology, Children s Memorial Hospital, Warsaw, Poland
    Clin Exp Immunol 134:482-90. 2003
    ....
  87. ncbi Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells
    Lori Broderick
    Department of Microbiology and Immunology, State University of New York, Buffalo, NY 14214, USA
    J Immunol 174:898-906. 2005
    ....
  88. ncbi B7+ T cells in myeloma: an acquired marker of prior chronic antigen presentation
    Ross Brown
    Institute of Haematology, Royal Prince Alfred Hospital, Sydney, NSW Australia
    Leuk Lymphoma 45:363-71. 2004
    ..B7+ CD45RO+ T cells constitute a population of memory T cells chronically exposed to antigen and warrant further study...
  89. ncbi Characterization of a B220+ lymphoid cell subpopulation with immune modulatory functions in nasal-associated lymphoid tissues
    Faiza Rharbaoui
    Division of Microbiology, GBF-German Research Center for Biotechnology, Braunschweig, Germany
    J Immunol 174:1317-24. 2005
    ....
  90. ncbi Early events in peripheral regulatory T cell induction via the nasal mucosa
    Wendy W J Unger
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Immunol 171:4592-603. 2003
    ..We are the first to demonstrate that functional T(R) cells, which reside within both CD25(+) and CD25(-) subsets, can be isolated from CLN as early as 3 days after nasal OVA application...
  91. ncbi Generation of potent antitumor CTL from patients with multiple myeloma directed against HM1.24
    Steven B Rew
    Department of Haematology, Royal Free and University College Medical School, London, United Kingdom
    Clin Cancer Res 11:3377-84. 2005
    ..Unmanipulated, or control plasmid-transfected dendritic cells had no effect on lysis of autologous MPC. CONCLUSION: Our results indicate that HM1.24 is a promising target for immunotherapy of multiple myeloma...
  92. ncbi Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function
    Gilberto Filaci
    Department of Internal Medicine, and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    Hum Immunol 65:142-56. 2004
    ..These findings can be helpful for the better understanding of immune regulatory circuits and for the definition of new pathogenic aspects in autoimmunity and tumor immunology...
  93. ncbi Cellular and molecular requirements for the recall of IL-4-producing memory CD4(+)CD45RO(+)CD27(-) T cells during protection induced by attenuated Plasmodium falciparum sporozoites
    Dupeh R Palmer
    Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Eur J Immunol 32:652-61. 2002
    ....
  94. ncbi In situ activation of helper T cells in the lung
    B Raju
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Infect Immun 69:4790-8. 2001
    ..Our data suggest that ex vivo experiments on helper T-cell subsets that display distinctive phenotypes may be pivotal to studies on the human immune response to potential TB vaccines...
  95. ncbi CD4(+) memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple sclerosis
    M Krakauer
    Danish Multiple Sclerosis Research Center, Department of Neurology, Section 2082, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Neuroimmunol 181:157-64. 2006
    ..These changes were only partially normalised by treatment with interferon-beta. We point to this subset as a putative target for immunological monitoring of MS disease activity and of treatment efficacy...
  96. ncbi SC35 plays a role in T cell development and alternative splicing of CD45
    H Y Wang
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 7:331-42. 2001
    ..This study establishes a model to address the function of SR proteins in physiological settings and reveals a critical role of SC35 in a T cell-specific regulated splicing pathway...
  97. ncbi In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity
    Julia Tsang
    Department of Nephrology and Transplantation, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom
    Int Immunopharmacol 6:1883-8. 2006
    ..The K(d)-specific CD4(+)CD25(+) T cell lines will be invaluable in devising a strategy for the induction of cardiac transplantation tolerance in wild-type B6 mice carrying a full mismatch BALB/c heart...
  98. ncbi Heterogeneity of circulating CD4+ memory T-cell subsets in erythrodermic patients: CD27 analysis can help to distinguish cutaneous T-cell lymphomas from inflammatory erythroderma
    M T Fierro
    Section of Dermatology, Department of Medical Sciences and Human Oncology, University of Turin, Turin, Italy
    Dermatology 216:213-21. 2008
    ..Recent findings suggest that different memory T-cell subsets can be recognized based on CD27 and CD45RO/RA expression. No data are reported as to CD27 expression in SS...
  99. ncbi Fetal calf serum-primed dendritic cells induce a strong anti-fetal calf serum immune response and diabetes protection in the non-obese diabetic mouse
    N Kadri
    Immuno endocrinology Unit, INRA U707, F 44307 Nantes, France
    Immunol Lett 108:129-36. 2007
    ..All together, our data show that DC transfer induced cellular and humoral anti-FCS immune responses in recipient NOD mice suggesting that the protective effect of DC relies on their unspecific immunostimulatory effects...
  100. ncbi Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis
    Marina Zafranskaya
    Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Germany
    Immunology 121:29-39. 2007
    ..Assessment of T-cell subsets and their reactivity to MOG may represent an important diagnostic tool for monitoring successful immunotherapy in MS...
  101. ncbi Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice
    T Benatar
    Wellesley Hospital Research Institute, University of Toronto, Canada
    J Exp Med 183:329-34. 1996
    ..While anti-Ig-induced mobilization of intracellular Ca2+ stores was normal, influx from extracellular sources was abrogated. This finding reveals a novel pathway of regulating B cell responses mediated by CD45...

Research Grants93

  1. Bispecific Antibody Engineering for AML RIT
    OLIVER W contact PRESS; Fiscal Year: 2010
    ..We anticipate that this approach will cure more patients and cause fewer toxicities than currently available therapies. ..
  2. CD45 Pretargeted Radioimmunotherapy for AML
    Oliver W Press; Fiscal Year: 2010
    ....
  3. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..These studies will provide fundamental insights into KC pathogensis and may provide a basis for therapy. ..
  4. GENETIC ANALYSIS OF REGULATION AND FUNCTION OF CD45
    William Raschke; Fiscal Year: 2002
    ..The roles of the extracellular domain, the cytoplasmic domain and critical functional sites will be evaluated in this manner. ..
  5. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2010
    ..We anticipate that these approaches will cure more patients and cause fewer toxicities than currently available therapies. ..
  6. Radioimmunotherapy of CD20+ Lymphomas & CD45+Leukemias
    JOHN PAGEL; Fiscal Year: 2007
    ..of RIT using a two-step streptavidin(SA)-biotin pretargeting strategy to target the anti-CD20 and anti-CD45 antigens on the surface of NHL and AML tumor cells, respectively...
  7. OPTIMIZING RADIOIMMUNOTHERAPY FOR NON HODGKIN'S LYMPHOMA
    Ajay Gopal; Fiscal Year: 2005
    ..We anticipate that these interventions will ultimately enhance the prognosis for patients with relapsed lymphoma by increasing the response and survival rates, while simultaneously minimizing toxicities. ..
  8. Proapoptotic Therapy for B-cell Non Hodgkin's Lymphoma
    Ajay Gopal; Fiscal Year: 2007
    ..The results of this project will be critical to the future development of this therapy and potentially lead to a novel, practical, inexpensive, well-tolerated, oral method to optimize the efficacy of anti-CD20 therapy for B-NHL. ..
  9. Radioimmunotherapy of Acute Leukemia
    Eneida Nemecek; Fiscal Year: 2007
    ....
  10. B220+ DN alphabeta T cell as a novel immunoregulatory T*
    ABDEL HAMAD; Fiscal Year: 2005
    ..The findings generated by these studies will aid in characterizing a novel naturally occurring regulatory T cells and define their role in peripheral and mucosal tolerance. ..
  11. B220+DN Tcells in Mucosal Tolerance and Inflammation
    ABDEL HAMAD; Fiscal Year: 2005
    ..In addition, they lay the groundwork for the analysis of B220+ DN T cell in healthy individuals and IBD patients. ..
  12. Role of CD45 in Hematopoiesis and Lymphomagenesis
    Michelle Hermiston; Fiscal Year: 2005
    ..These studies should provide important insights into the links between immune regulation, autoimmunity, and lymphoid malignancies as well as improve our understanding of the mechanisms governing immune surveillance. ..
  13. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2007
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. ..
  14. Novel hematopoietic effects of C3 cleavage fragments
    Mariusz Z Ratajczak; Fiscal Year: 2010
    ..We will test the hypothesis that this defect is related to the lack of naturally occurring C cascade-activating IgM antibodies. ..
  15. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2007
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. ..
  16. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  17. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2007
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  18. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
    ..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
  19. Int'l Society for Trace Elements Research in Humans
    Harold Sandstead; Fiscal Year: 2005
    ....
  20. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  21. TCR GENE USAGE AND QUANTITATION OF HIV SPECIFIC CTL
    Spyros Kalams; Fiscal Year: 2001
    ..Understanding the contribution of the HIV-1- specific CTL response to long-term non progressing infection may lead to practical strategies to augment this arm of the immune response. ..
  22. Effects of BMPRII Mutations in Pulmonary Hypertension
    James West; Fiscal Year: 2005
    ..We will have also tested the role of four pulmonary cell types, smooth muscle, endothelium, airway epithelium and macrophages in the link between BMPR2 and pulmonary hypertension. ..
  23. Novel hematopoietic effects of C3 cleavage fragments
    Mariusz Ratajczak; Fiscal Year: 2007
    ..We will test the hypothesis that this defect is related to the lack of naturally occurring C cascade-activating IgM antibodies. ..
  24. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  25. TCR Genes and HIV-Specific Cytotoxic T-lymphocytes
    Spyros Kalams; Fiscal Year: 2006
    ..4) Determine whether the generation of a diverse TCR repertoire contains populations of high-avidity CTL that come to dominate the population of CTL during chronic infection and mediate control of HIV- 1 replication. ..