cd45 antigens

Summary

Summary: High-molecular weight glycoproteins uniquely expressed on the surface of all leukocytes and their hemopoietic progenitors. The CD45 family consists of multiple members that are all products of a single gene. CD45 expression is necessary for signaling through the T-cell receptor.

Top Publications

  1. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
  2. ncbi Control of intestinal inflammation by regulatory T cells
    B Singh
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 182:190-200. 2001
  3. pmc Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages
    Elena Chertova
    AIDS Vaccine Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    J Virol 80:9039-52. 2006
  4. pmc Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    J Clin Invest 114:438-46. 2004
  5. doi Increased circulating fibrocytes in asthma with chronic airflow obstruction
    Chun Hua Wang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, 199 Tun Hwa North Road, Taipei, Taiwan
    Am J Respir Crit Care Med 178:583-91. 2008
  6. pmc Muscle-derived hematopoietic stem cells are hematopoietic in origin
    Shannon L McKinney-Freeman
    Department of Pediatrics, Center for Cell and Gene Therapy, BCM 505, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:1341-6. 2002
  7. pmc A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
    Gesine Kogler
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Exp Med 200:123-35. 2004
  8. pmc Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10162-72. 2006
  9. ncbi Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro
    D H Ng
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    J Biol Chem 271:1295-300. 1996
  10. pmc Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood
    Sonja Kimmig
    Department of Clinical Immunology, Deutsches Rheuma ForschungsZentrum Berlin, Schumannstrasse 21 22, 10117 Berlin, Germany
    J Exp Med 195:789-94. 2002

Detail Information

Publications215 found, 100 shown here

  1. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  2. ncbi Control of intestinal inflammation by regulatory T cells
    B Singh
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 182:190-200. 2001
    ....
  3. pmc Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages
    Elena Chertova
    AIDS Vaccine Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    J Virol 80:9039-52. 2006
    ..MDM-derived HIV contained 26 of 37 proteins previously found in exosomes, consistent with the idea that HIV uses the late endosome/multivesicular body pathway during virion budding from macrophages...
  4. pmc Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
    J Clin Invest 114:438-46. 2004
    ..Thus, our results demonstrate, we believe for the first time, that circulating fibrocytes contribute to the pathogenesis of pulmonary fibrosis...
  5. doi Increased circulating fibrocytes in asthma with chronic airflow obstruction
    Chun Hua Wang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, 199 Tun Hwa North Road, Taipei, Taiwan
    Am J Respir Crit Care Med 178:583-91. 2008
    ..We hypothesized that this effect may result from increased activity of circulating fibroblast-like progenitor cells (fibrocytes) that could home to the airway mucosal wall...
  6. pmc Muscle-derived hematopoietic stem cells are hematopoietic in origin
    Shannon L McKinney-Freeman
    Department of Pediatrics, Center for Cell and Gene Therapy, BCM 505, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:1341-6. 2002
    ..Although CD45-negative cells were highly myogenic in vitro and in vivo, CD45-positive muscle-derived cells displayed only very limited myogenic activity and only in vivo...
  7. pmc A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
    Gesine Kogler
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Exp Med 200:123-35. 2004
    ..No tumor formation was observed in any of these animals...
  8. pmc Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10162-72. 2006
    ..Taken together, the loss of HIV-specific CD4+ T cells is associated with a combination of an infection of CCR5+ CD127+ memory CD4+ T cells, possibly in GALT, and a high expression of the inhibitory receptor CTLA-4...
  9. ncbi Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro
    D H Ng
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    J Biol Chem 271:1295-300. 1996
    ..In addition, this interaction occurred in the absence of any detectable tyrosine phosphorylation on CD45, suggesting a nonconventional SH2 domain interaction...
  10. pmc Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood
    Sonja Kimmig
    Department of Clinical Immunology, Deutsches Rheuma ForschungsZentrum Berlin, Schumannstrasse 21 22, 10117 Berlin, Germany
    J Exp Med 195:789-94. 2002
    ..We describe here the identification of peripherally expanded naive Th cells in human adult blood characterized by the loss of CD31 expression and a highly reduced TREC content...
  11. ncbi The role of CD45 and CD45-associated molecules in T cell activation
    J G Altin
    Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, Australian National University, Canberra, Australia
    Immunol Cell Biol 75:430-45. 1997
    ..This review aims to summarize recent findings on the role of CD45 and CD45-associated molecules in T cell activation, and to highlight issues that seem relevant to ongoing research in this area...
  12. ncbi Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs
    Pierre Brawand
    Amgen Inc, Seattle, WA 98101, USA
    J Immunol 169:6711-9. 2002
    ..Thus, the in vitro generation of murine pDCs may serve as a useful tool to further investigate pDC biology as well as the potential role of these cells in viral immunity and other settings...
  13. ncbi Flow cytometric analysis of inflammatory cells in ischemic rat brain
    Marilena Campanella
    Schering Plough Research Institute, Milan, Italy
    Stroke 33:586-92. 2002
    ..However, this technique has not been applied to the study of cerebral ischemia inflammation. The aim of this study was to establish a flow cytometric method to measure inflammatory cells in ischemic brain...
  14. ncbi Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    R E Mebius
    Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Immunity 7:493-504. 1997
    ..Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture...
  15. pmc The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase
    H Charbonneau
    Department of Biochemistry, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 85:7182-6. 1988
    ....
  16. ncbi Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease
    C Kung
    Howard Hughes Medical Institute, St Louis, Missouri 63110, USA
    Nat Med 6:343-5. 2000
    ..Despite normal B-lymphocyte numbers, serum immunoglobulin levels decreased with age. Thus, CD45 deficiency in humans results in T- and B-lymphocyte dysfunction...
  17. ncbi Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis
    Melissa A Cosenza
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Pathol 12:442-55. 2002
    ..Because productively infected tissue macrophages serve as the major viral reservoir, these findings have important implications for AIDS...
  18. ncbi Little evidence for developmental plasticity of adult hematopoietic stem cells
    Amy J Wagers
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 297:2256-9. 2002
    ..These data indicate that "transdifferentiation" of circulating HSCs and/or their progeny is an extremely rare event, if it occurs at all...
  19. pmc CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules
    Shoham Shivtiel
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 205:2381-95. 2008
    ..Uncoupling environmental and intrinsic defects in chimeric mice, we demonstrated that CD45 regulates progenitor movement and retention by influencing both the hematopoietic and nonhematopoietic compartments...
  20. ncbi IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    M Hara
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 166:3789-96. 2001
    ....
  21. ncbi CD4+CD25high regulatory cells in human peripheral blood
    C Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 167:1245-53. 2001
    ....
  22. ncbi Evidence that HIV budding in primary macrophages occurs through the exosome release pathway
    Deborah Greene Nguyen
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:52347-54. 2003
    ..These results strongly support the Trojan exosome hypothesis and its prediction that retroviral budding represents exploitation of a pre-existing cellular pathway of intercellular vesicle trafficking...
  23. ncbi Persistence of naive CD45RA+ regulatory T cells in adult life
    Nabila Seddiki
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW, Australia 2042
    Blood 107:2830-8. 2006
    ..Targeting naive TREGs in adults may offer new means of preventing and treating autoimmune disease...
  24. ncbi Measurement and modeling of human T cell kinetics
    Derek C Macallan
    Department of Infectious Diseases, St George s Hospital Medical School, London, GB
    Eur J Immunol 33:2316-26. 2003
    ..The new kinetic model fits the data closely and avoids the need to postulate a large external source of lymphocytes to maintain equilibrium...
  25. ncbi Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase
    N K Tonks
    Department of Biochemistry, University of Washington, Seattle 98195
    Biochemistry 27:8695-701. 1988
    ..No shift in CD45 or PTPase was observed following addition of a control IgG2a. On this basis, it is concluded that CD45 is a protein tyrosine phosphatase...
  26. ncbi Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration
    Anna Polesskaya
    Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6
    Cell 113:841-52. 2003
    ..Our data therefore suggest that mobilization of resident CD45(+) stem cells is an important factor in regeneration after injury and highlight the Wnt pathway as a potential therapeutic target for degenerative neuromuscular disease...
  27. pmc Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR
    M Streuli
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    EMBO J 9:2399-407. 1990
    ..It is suggested that this stretch of amino acids may be part of the catalytic center of PTPases...
  28. ncbi Lack of CD27-CD45RA-V gamma 9V delta 2+ T cell effectors in immunocompromised hosts and during active pulmonary tuberculosis
    Cristiana Gioia
    Laboratory of Clinical Pathology Immunopathology, Padiglione Del Vecchio, National Institute for Infectious Diseases, Lazzaro Spallanzani, Institute for Cancer Research and Treatment, Via Portuense 292, 00149 Rome, Italy
    J Immunol 168:1484-9. 2002
    ..These observations indicate that monitoring and boosting gammadelta T cell effectors could be clinically relevant both in immunocompromised hosts and during active tuberculosis disease...
  29. ncbi Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation
    J T Pingel
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 58:1055-65. 1989
    ..An L-CA+ revertant was obtained and the ability to proliferate in response to antigen and cross-linked CD3 was restored. These data indicate that L-CA is required for T cells to enter into cell cycle in response to antigen...
  30. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  31. ncbi MHC II+ CD45+ cells from synovium-rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitro
    Mahin Moghaddami
    Arthritis Research Laboratory, Hanson Institute for Medical Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Int Immunol 17:1103-15. 2005
    ..These results demonstrate that SRTs contain indeterminate cells that can differentiate into mature DCs in vitro in response to GM-CSF, plus mature synovial lining macrophages...
  32. ncbi Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms
    Zheng Xu
    Department of Medicine and The Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0795, USA
    Nat Immunol 3:764-71. 2002
    ..Our results not only demonstrate the biological significance of alternative splicing in the immune system, but also suggest a model for regulating RPTP dimerization and function...
  33. ncbi CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway
    S Lesage
    Institut de Recherches Cliniques de Montreal, Quebec, Canada
    J Immunol 159:4762-71. 1997
    ..We propose that during T cell development, CD45 ligation could induce the death of those immature thymocytes that do not fulfill the requirements for positive selection...
  34. pmc Antigen-capturing cells can masquerade as memory B cells
    Jennifer Bell
    Institute of Cell, Animal, and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Rd, Edinburgh EH9 3JT UK
    J Exp Med 197:1233-44. 2003
    ..We find no evidence of a B220- memory B cell population that is not explicable by antigen-capturing cells, and warn that care must be taken when using antigen-specificity or surface IgG as an indicator of B cell memory...
  35. ncbi Long-term allograft acceptance induced by single dose anti-leukocyte common antigen (RT7) antibody in the rat
    S Ko
    , Medizinische Hochschule Hannover, Germany
    Transplantation 71:1124-31. 2001
    ..Local immunoregulatory mechanisms seem to play a role for maintenance of long-term graft acceptance...
  36. ncbi Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties
    Lisheng Wang
    Robarts Research Institute, Krembil Centre for Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    Immunity 21:31-41. 2004
    ....
  37. ncbi CD45: direct and indirect government of immune regulation
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Immunol Lett 94:167-74. 2004
    ....
  38. ncbi TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis
    J J Bleesing
    Immunology Service, Warren G Magnuson Clinical Center, Bethesda, Maryland 20892, USA
    Clin Immunol 100:314-24. 2001
    ....
  39. ncbi The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct
    Veronique Baron
    Unité de Biologie Moléculaire du Gène, INSERM U277, Paris, France
    Immunity 18:193-204. 2003
    ..Altogether, these observations suggest that most effector memory T cells may not have derived from the central memory subset...
  40. ncbi Transient RNA interference in hematopoietic progenitors with functional consequences
    Daniela M Oliveira
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 36:203-8. 2003
    ..These results demonstrate that transient transfection of siRNA to primary cells can have substantial functional consequences. This technology may be applicable to a variety of primary cell types...
  41. pmc Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    Joachim Lehmann
    Experimentelle Rheumatologie, Universitatsklinikum Charite, Humboldt Universitat, c o Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 99:13031-6. 2002
    ..Thus, the integrin alpha(E)beta(7) can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments...
  42. ncbi Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice
    P J Mee
    National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Eur J Immunol 29:2923-33. 1999
    ..Our results conclusively demonstrate that in double-positive thymocytes CD45 is a positive regulator of the TCR signals that drive thymic selection events...
  43. ncbi CD4+ CD45RB low-density cells from untreated mice prevent acute allograft rejection
    J D Davies
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 163:5353-7. 1999
    ..Unexpectedly, the CD45RB low-density cells prevent the CD45RBhigh expressing cells from causing rejection. These data suggest that the response to foreign tissue can be controlled in the same way as the response to self-tissue...
  44. ncbi Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases
    Christophe Blanchetot
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands
    J Biol Chem 277:47263-9. 2002
    ..The RPTP-D2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs...
  45. ncbi A deletion in the gene encoding the CD45 antigen in a patient with SCID
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 166:1308-13. 2001
    ....
  46. pmc Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia
    Mee Ohk Kim
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Virol 80:62-72. 2006
    ..alphaCD45RO-mediated inhibition of HIV-1 replication in microglia identifies the CD45 protein tyrosine phosphatase as a potential therapeutic target for HIV-1 infection/AIDS dementia...
  47. pmc The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
    A Saoudi
    Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 184:2393-8. 1996
    ....
  48. ncbi Alterations in the level of CD45 surface expression affect the outcome of thymic selection
    V A Wallace
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    J Immunol 158:3205-14. 1997
    ..These data demonstrate that changes in the expression level of the receptor protein tyrosine phosphatase CD45 can alter thymic selection...
  49. ncbi Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase
    T Mustelin
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Eur J Immunol 25:942-6. 1995
    ..These findings suggest that CD45 plays an important role, direct or indirect, in the regulation of p70zap and its function in TcR/CD3 signaling...
  50. ncbi Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis
    Jennifer N Solomon
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Glia 53:744-53. 2006
    ..Thus, we demonstrate that the microgliosis present in spinal cord tissue of mSOD mice is primarily due to an expansion of resident microglia and not to the recruitment of microglial precursors from the circulation...
  51. ncbi B220+ double-negative T cells suppress polyclonal T cell activation by a Fas-independent mechanism that involves inhibition of IL-2 production
    Abdel Rahim A Hamad
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Ross 659, Baltimore, MD 21205, USA
    J Immunol 171:2421-6. 2003
    ..These findings suggest that B220+ DN T cells may be involved in controlling autoreactive T cells in the absence of Fas-mediated peripheral tolerance...
  52. pmc Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
    J D Sedgwick
    Institute for Virology and Immunobiology, University of Wurzburg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 88:7438-42. 1991
    ..In normal CNS, a very small population of blood-derived CD45high-expressing cells are present; most MHC class II expression is associated with these few cells and not with the resident microglia...
  53. pmc CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, 75015 Paris, France
    J Exp Med 204:2569-78. 2007
    ..1(+) cells upon activation in vitro or in vivo in a proliferation-dependent fashion. Our data suggest that the majority of CD11c(lo)B220(+) "IKDC-like" cells represent activated NK cells...
  54. ncbi Differentiation of human CD8(+) T cells from a memory to memory/effector phenotype
    Hiroko Tomiyama
    Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan
    J Immunol 168:5538-50. 2002
    ..The presence of a CD27(-)CD28(+) subset with a CCR5(+)CCR7(-) phenotype implies a specialized role for this subset in the differentiation of CD8(+) T cells...
  55. ncbi Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes
    U D'Oro
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 162:1879-83. 1999
    ..These results support a model in which CD45 dephosphorylates both Tyr505 and Tyr394, the net effect in normal thymocytes being a decrease in enzymatic activity...
  56. pmc CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
    K F Byth
    Department of Pathology, Cambridge University, United Kingdom
    J Exp Med 183:1707-18. 1996
    ..We conclude that CD45 is not required at any stage during the generation of mature peripheral B cells, however its loss reveals a previously unrecognized role for CD45 in the regulation of certain subpopulations of B cells...
  57. ncbi A novel dendritic cell subset involved in tumor immunosurveillance
    Julien Taieb
    ERM0208 INSERM, Faculté de Médecine Kremlin Bicêtre, Institut Gustave Roussy, Villejuif, France
    Nat Med 12:214-9. 2006
    ..In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response...
  58. pmc Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners
    Fernando D Camargo
    Center for Cell and Gene Therapy, Baylor College of Medicinem Houston, Texas 77098, USA
    J Clin Invest 113:1266-70. 2004
    ..Our findings raise the possibility that differentiated myeloid cells may be useful for future therapeutic applications of in vivo cellular fusion...
  59. ncbi Peripheral macrophage recruitment in cuprizone-induced CNS demyelination despite an intact blood-brain barrier
    Eileen J McMahon
    Department of Microbiology and Immunology, University of North Carolina, 27599, Chapel Hill, NC, USA
    J Neuroimmunol 130:32-45. 2002
    ..While the peripheral macrophages were far outnumbered by the resident microglia, their recruitment across the blood-brain barrier alludes to a potentially important role...
  60. pmc Quantitation of HLA class II protein incorporated into human immunodeficiency type 1 virions purified by anti-CD45 immunoaffinity depletion of microvesicles
    Charles M Trubey
    Basic Research Program Research Technology Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    J Virol 77:12699-709. 2003
    ..Our observations demonstrate the utility of CD45 immunoaffinity-based approaches for producing highly purified retrovirus preparations for applications that would benefit from the use of virus that is essentially free of microvesicles...
  61. ncbi Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates
    Fernando D Camargo
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, BCM505, Houston, Texas 77030, USA
    Nat Med 9:1520-7. 2003
    ..Our results indicate that circulating myeloid cells, in response to inflammatory cues, migrate to regenerating skeletal muscle and stochastically incorporate into mature myofibers...
  62. pmc CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis
    Melissa A Cosenza-Nashat
    Department of Science, BMCC, City University of New York, New York, NY, USA
    Brain Pathol 16:256-65. 2006
    ..RO was low in control microglia, but increased in HIVE. RO was also localized to macrophages and CD8+ T cells. Targeting CD45 in vivo with isoform-specific antibodies remains a therapeutic option for neuroinflammatory diseases...
  63. ncbi Increased resistin gene and protein expression in human abdominal adipose tissue
    Philip G McTernan
    Division of Medical Sciences, Department of Medicine, University of Birmingham, Birmingham, B15 2TH, UK
    J Clin Endocrinol Metab 87:2407. 2002
    ..In conclusion, this study confirms the expression of resistin in human adipose tissue and increased expression in abdominal fat, this suggests a potential role in linking central obesity to type 2 diabetes and/or cardiovascular disease...
  64. pmc Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair
    Carrie Fathke
    Department of Surgery, Box 356410, University of Washington Medical Center, 1959 NE Pacific Street, Seattle 98195, USA
    Stem Cells 22:812-22. 2004
    ....
  65. ncbi Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells
    Kristin Chadwick
    Robarts Research Institute, Stem Cell Biology and Regenerative Medicine, 100 Perth Dr, London, ON N6A 5K8, Canada
    Blood 102:906-15. 2003
    ....
  66. ncbi Persistent expansion of CD4+ effector memory T cells in Wegener's granulomatosis
    W H Abdulahad
    Department of Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 70:938-47. 2006
    ..Collectively, peripheral blood homeostasis of CD4+T cells is disturbed in R-WG with the persistent expansion of non-regulatory CD4+TEM cells. These cells might be involved in relapse and may constitute a target for therapy...
  67. ncbi B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    Jun Konishi
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Clin Cancer Res 10:5094-100. 2004
    ..Furthermore, we examined the correlation between B7-H1 expression on tumor cells and the number of tumor-infiltrating lymphocytes (TILs) or PD-1 expression on TILs...
  68. ncbi Apoptosis of T cells mediated by galectin-1
    N L Perillo
    UCLA Department of Pathology and Laboratory Medicine, Los Angeles, California 90095 1732, USA
    Nature 378:736-9. 1995
    ..Induction of apoptosis by an endogenous mammalian lectin represents a new mechanism for regulating the immune response...
  69. ncbi Expression of the chemokine RANTES in pulmonary Wegener's granulomatosis
    F Capron
    INSERM U131, Institut Paris Sud sur les Cytokines, Clamart, France
    Hum Pathol 32:320-6. 2001
    ..hum pathol 32:320-326...
  70. ncbi CD45 regulated signaling pathways
    Junko Irie-Sasaki
    Departments of Pharmacology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    Curr Top Med Chem 3:783-96. 2003
    ..Modulation of CD45 splice variants and CD45 activity might provide a unique opportunity to design drugs that turn off or turn-on antigen and cytokine receptor signaling in cancer, allergy, transplantation, or autoimmunity...
  71. ncbi Liver-derived DEC205+B220+CD19- dendritic cells regulate T cell responses
    L Lu
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Immunol 166:7042-52. 2001
    ..In vivo administration of liver DEC205+B220+CD19- cells significantly prolonged the survival of vascularized cardiac allografts in an alloantigen-specific manner...
  72. ncbi Functional defect of circulating regulatory CD4+ T cells in patients with Wegener's granulomatosis in remission
    Wayel H Abdulahad
    University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 56:2080-91. 2007
    ..The objective of this study was to test whether the frequency and/or function of Treg cells from WG patients in remission are disturbed...
  73. ncbi Physiological migration of hematopoietic stem and progenitor cells
    D E Wright
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 294:1933-6. 2001
    ..These data demonstrate that HSCs rapidly and constitutively migrate through the blood and play a physiological role in, at least, the functional reengraftment of unconditioned bone marrow...
  74. pmc Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells
    Iiro Rajantie
    Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Blood 104:2084-6. 2004
    ..Thus, the major contribution of the BM to angiogenic processes is not endothelial, but may come from progenitors for periendothelial vascular mural and hematopoietic effector cells...
  75. pmc HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity
    Souheil Antoine Younes
    Departement de Microbiologie et Immunologie, Universite de Montreal, 2900 Edouard Montpetit Boulevard, Montreal H3T 1J4, Canada
    J Exp Med 198:1909-22. 2003
    ..Our data favor a model whereby competent HIV-specific Tcm continuously arise in small numbers but under persistent antigenemia are rapidly induced to differentiate into IFN-gamma only-producing cells that lack self-renewal capacity...
  76. ncbi Identification and analysis of in vitro cultured CD45-positive cells capable of multi-lineage differentiation
    Ian Rogers
    Department of Obstetrics and Gynaecology, Rm 876 Samuel Lunenfeld Research Institute, Mount Sinai Hospital and the University of Toronto, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
    Exp Cell Res 313:1839-52. 2007
    ..Clonal cell analysis determined that the culture period caused a broadening in the differentiation potential of the starting population...
  77. ncbi Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma
    J P Lamb
    Dept of Pulmonary Physiology, Sir Charles Gairdner Hospital, Hospital Avenue, 6009 Nedlands, WA, Australia
    Eur Respir J 26:265-70. 2005
    ..It is possible that survival signals may be received before cells migrate into the interstitium of the inner airway wall...
  78. ncbi Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors
    Meredith O'Keeffe
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 101:1453-9. 2003
    ..These findings indicate the close relationship between human and mouse DCs, provided cells are obtained directly from equivalent source materials...
  79. ncbi Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    Victor Appay
    MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Med 8:379-85. 2002
    ..These findings challenge the current definitions of memory and effector subsets in humans, and suggest that ascribing effector and memory functions to subsets with different differentiation phenotypes is no longer appropriate...
  80. ncbi New insights into the transmembrane protein tyrosine phosphatase CD45
    T Sasaki
    Department of Pharmacology, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, 113 8613, Tokyo, Japan
    Int J Biochem Cell Biol 33:1041-6. 2001
    ..Modulation of CD45 splice variants provides a unique opportunity to design drugs that turn off or turn on antigen and cytokine receptor signaling in cancer, transplantation or autoimmunity..
  81. ncbi Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation
    Jackie Felberg
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 279:3455-62. 2004
    ..This demonstrates a role for CD45-D2 in binding substrate and identifies the SD10 region in Lck as a novel site involved in substrate recognition...
  82. ncbi A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential
    Gina Balciunaite
    Developmental and Molecular Immunology, Center for Biomedicine Department of Clinical and Biological Sciences DKBW, University of Basel, Basel, Switzerland
    Eur J Immunol 35:2019-30. 2005
    ..The relationship between B220+ CD117+ CD19- NK1.1- cells of wild-type mice and other multi-lineage BM progenitors is discussed...
  83. ncbi Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development
    A Kumanogoh
    Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Japan
    J Immunol 166:353-60. 2001
    ..Collectively, our results indicate that CD40-CD40L interactions contribute to negative regulation of T cell autoreactivity and that defective interactions can lead to autoimmunity...
  84. ncbi Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt
    Hyeon Sook Suh
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 174:2712-9. 2005
    ..Ab-mediated activation of macrophage and microglial CD45 tyrosine phosphatase may have therapeutic implications for CNS inflammatory diseases...
  85. ncbi Neural stem cells in the subventricular zone are a source of astrocytes and oligodendrocytes, but not microglia
    Steven W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Dev Neurosci 25:184-96. 2003
    ..Therefore, the microglia that reside in the SVZDL are immigrants from nonneural precursors...
  86. pmc Generation and characterization of novel stromal specific antibodies
    Sapna Halder
    Prostate Cancer Research Centre, Institute of Urology 3rd floor, University College London, UK
    Cell Res 15:739-44. 2005
    ..A fibroblast-specific antibody that did not also identify vessels was not generated. Examples of each reactivity pattern are discussed...
  87. ncbi Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
    J G Cyster
    Department of Microbiology and Immunology, Program in Immunology, Stanford University School of Medicine, California 94305, USA
    Nature 381:325-8. 1996
    ....
  88. pmc Mature CD8(+) T lymphocyte response to viral infection during fetal life
    Arnaud Marchant
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Invest 111:1747-55. 2003
    ..The finding of a mature and functional CD8(+) T cell response to HCMV suggests that the machinery required to prime such responses is in place during fetal life and could be used to immunize newborns against viral pathogens...
  89. ncbi A quasi-monoclonal mouse
    M Cascalho
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0670, USA
    Science 272:1649-52. 1996
    ..Thus, neither network interactions nor random activation of a small fraction of the B cell population can account for serum Ig concentrations...
  90. ncbi Functional maturation of CD4+CD25+CTLA4+CD45RA+ T regulatory cells in human neonatal T cell responses to environmental antigens/allergens
    Catherine A Thornton
    School of Medicine, University of Wales, Swansea, United Kingdom
    J Immunol 173:3084-92. 2004
    ....
  91. ncbi The accumulation of B220+ CD4- CD8- (DN) T cells in C3H-lpr/lpr mice is not accelerated by the stimulation of CD8+ T cells or B220+ DN T cells with staphylococcal enterotoxin B and occurs independently of V beta 8+ T cells
    T Giese
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int Immunol 7:1213-23. 1995
    ..In contrast to previous reports, chronic elimination of V beta 8+ T cells had no effect on the accumulation of B220+ DN T cells.(ABSTRACT TRUNCATED AT 400 WORDS)..
  92. ncbi Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy
    Shujuan Liu
    Surgery Branch, National Cancer Institute NCI, Bethesda, Maryland 20892 1502, USA
    J Immunother 29:284-93. 2006
    ....
  93. ncbi Chemotactically-induced redistribution of CD43 as related to polarity and locomotion of human polymorphonuclear leucocytes
    A Dehghani Zadeh
    Institute of Pathology, University of Bern, 3010 Bern, Switzerland
    Biol Cell 95:265-73. 2003
    ..Our data show that anterior pseudopod formation, rather than capping of CD43 at the uropod or the position of the uropod determines the direction of locomotion...
  94. doi Heterogeneity of circulating CD4+ memory T-cell subsets in erythrodermic patients: CD27 analysis can help to distinguish cutaneous T-cell lymphomas from inflammatory erythroderma
    M T Fierro
    Section of Dermatology, Department of Medical Sciences and Human Oncology, University of Turin, Turin, Italy
    Dermatology 216:213-21. 2008
    ..Recent findings suggest that different memory T-cell subsets can be recognized based on CD27 and CD45RO/RA expression. No data are reported as to CD27 expression in SS...
  95. pmc Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models
    P Maerten
    Laboratory of Experimental Immunology, University Hospital of Leuven, Belgium
    Clin Exp Immunol 135:310-7. 2004
    ..In view of the divergent effects of IL-18 neutralization in the two different murine colitis models, it is unlikely that IL-18 is at the top of this cascade...
  96. ncbi Regulation of chronic colitis in athymic nu/nu (nude) mice
    F Stephen Laroux
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, 1501 Kings Highway, LA 71130, USA
    Int Immunol 16:77-89. 2004
    ..In addition, our data demonstrate that suppression of disease may be due to polarization of naive CD4(+) cells toward a non-pathogenic and/or regulatory phenotype...
  97. doi Association of Graves' disease and prevalence of circulating IFN-gamma-producing CD28(-) T cells
    Zhiping Sun
    Medical Biotechnology Institute, Soochow University, 48 Renmin Road, Suzhou 215007, China
    J Clin Immunol 28:464-72. 2008
    ..Peripheral blood CD4(+) and CD8(+) T-cell subsets lacking surface CD28 have been suggested to predispose patients to immune-mediated disorders...
  98. pmc Intracellular calcium signalling patterns reflect the differentiation status of human T cells
    H P Arrol
    Department of Rheumatology, Division of Immunity and Infection, School of Medicine, University of Birmingham, UK
    Clin Exp Immunol 153:86-95. 2008
    ....
  99. ncbi IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine
    Karen G Hogg
    Department of Biology Area 5, PO Box 373, University of York, York YO10 5YW, UK
    Int Immunol 15:1451-9. 2003
    ....
  100. ncbi Characterization of HLA DR2 and DQ8 transgenic mouse with a new engineered mouse class II deletion, which lacks all endogenous class II genes
    S Cheng
    Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Autoimmun 21:195-9. 2003
    ..Therefore, this new class of HLA transgenic mice is the first to be completely "humanized" in their MHC class II genes and will be an invaluable mouse model for human MHC class II associated autoimmune diseases...
  101. doi Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis
    Teruji Totsuka
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 38:1275-86. 2008
    ..Thus, colitogenic LP CD4(+) cells may be exhausted over time, become non-functional, convert to regulatory cells, and finally suppress colitis in the process of immunosenescence...

Research Grants93

  1. Bispecific Antibody Engineering for AML RIT
    OLIVER W contact PRESS; Fiscal Year: 2010
    ..We anticipate that this approach will cure more patients and cause fewer toxicities than currently available therapies. ..
  2. CD45 Pretargeted Radioimmunotherapy for AML
    Oliver W Press; Fiscal Year: 2010
    ....
  3. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..These studies will provide fundamental insights into KC pathogensis and may provide a basis for therapy. ..
  4. GENETIC ANALYSIS OF REGULATION AND FUNCTION OF CD45
    William Raschke; Fiscal Year: 2002
    ..The roles of the extracellular domain, the cytoplasmic domain and critical functional sites will be evaluated in this manner. ..
  5. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2010
    ..We anticipate that these approaches will cure more patients and cause fewer toxicities than currently available therapies. ..
  6. Radioimmunotherapy of CD20+ Lymphomas & CD45+Leukemias
    JOHN PAGEL; Fiscal Year: 2007
    ..of RIT using a two-step streptavidin(SA)-biotin pretargeting strategy to target the anti-CD20 and anti-CD45 antigens on the surface of NHL and AML tumor cells, respectively...
  7. OPTIMIZING RADIOIMMUNOTHERAPY FOR NON HODGKIN'S LYMPHOMA
    Ajay Gopal; Fiscal Year: 2005
    ..We anticipate that these interventions will ultimately enhance the prognosis for patients with relapsed lymphoma by increasing the response and survival rates, while simultaneously minimizing toxicities. ..
  8. Proapoptotic Therapy for B-cell Non Hodgkin's Lymphoma
    Ajay Gopal; Fiscal Year: 2007
    ..The results of this project will be critical to the future development of this therapy and potentially lead to a novel, practical, inexpensive, well-tolerated, oral method to optimize the efficacy of anti-CD20 therapy for B-NHL. ..
  9. Radioimmunotherapy of Acute Leukemia
    Eneida Nemecek; Fiscal Year: 2007
    ....
  10. B220+ DN alphabeta T cell as a novel immunoregulatory T*
    ABDEL HAMAD; Fiscal Year: 2005
    ..The findings generated by these studies will aid in characterizing a novel naturally occurring regulatory T cells and define their role in peripheral and mucosal tolerance. ..
  11. B220+DN Tcells in Mucosal Tolerance and Inflammation
    ABDEL HAMAD; Fiscal Year: 2005
    ..In addition, they lay the groundwork for the analysis of B220+ DN T cell in healthy individuals and IBD patients. ..
  12. Role of CD45 in Hematopoiesis and Lymphomagenesis
    Michelle Hermiston; Fiscal Year: 2005
    ..These studies should provide important insights into the links between immune regulation, autoimmunity, and lymphoid malignancies as well as improve our understanding of the mechanisms governing immune surveillance. ..
  13. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2007
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. ..
  14. Novel hematopoietic effects of C3 cleavage fragments
    Mariusz Z Ratajczak; Fiscal Year: 2010
    ..We will test the hypothesis that this defect is related to the lack of naturally occurring C cascade-activating IgM antibodies. ..
  15. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2007
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. ..
  16. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  17. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2007
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  18. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
    ..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
  19. Int'l Society for Trace Elements Research in Humans
    Harold Sandstead; Fiscal Year: 2005
    ....
  20. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  21. TCR GENE USAGE AND QUANTITATION OF HIV SPECIFIC CTL
    Spyros Kalams; Fiscal Year: 2001
    ..Understanding the contribution of the HIV-1- specific CTL response to long-term non progressing infection may lead to practical strategies to augment this arm of the immune response. ..
  22. Effects of BMPRII Mutations in Pulmonary Hypertension
    James West; Fiscal Year: 2005
    ..We will have also tested the role of four pulmonary cell types, smooth muscle, endothelium, airway epithelium and macrophages in the link between BMPR2 and pulmonary hypertension. ..
  23. Novel hematopoietic effects of C3 cleavage fragments
    Mariusz Ratajczak; Fiscal Year: 2007
    ..We will test the hypothesis that this defect is related to the lack of naturally occurring C cascade-activating IgM antibodies. ..
  24. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  25. TCR Genes and HIV-Specific Cytotoxic T-lymphocytes
    Spyros Kalams; Fiscal Year: 2006
    ..4) Determine whether the generation of a diverse TCR repertoire contains populations of high-avidity CTL that come to dominate the population of CTL during chronic infection and mediate control of HIV- 1 replication. ..