cd2 antigens

Summary

Summary: Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex.

Top Publications

  1. ncbi Regulation of the interferon-inducible p53 target gene TRIM22 (Staf50) in human T lymphocyte activation
    Susanna Obad
    Department of Haematology and Transfusion Medicine, Lund University, S 221 84 Lund, Sweden
    J Interferon Cytokine Res 27:857-64. 2007
  2. ncbi DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing
    Alexander Saveliev
    CSC Gene Control Mechanisms and Disease Group, Experimental Genetics, Faculty of Medicine, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 422:909-13. 2003
  3. ncbi The CD2 family of natural killer cell receptors
    M E McNerney
    Department of Pathology, Committee on Immunology, University of Chicago, 5841 S Maryland Ave, S 315 MC3083, Chicago, IL 60637, USA
    Curr Top Microbiol Immunol 298:91-120. 2006
  4. pmc Analysis of the immune response to Mycobacterium avium subsp. paratuberculosis in experimentally infected calves
    Hye Cheong Koo
    Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Infect Immun 72:6870-83. 2004
  5. ncbi CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells
    S J Teh
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    Blood 89:1308-18. 1997
  6. pmc The mature activating natural killer cell immunologic synapse is formed in distinct stages
    Jordan S Orange
    Department of Molecular and Cellular Biology, 7 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:14151-6. 2003
  7. ncbi Human natural killer cell adhesion molecules. Differential expression after activation and participation in cytolysis
    M J Robertson
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 145:3194-201. 1990
  8. ncbi A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts
    M L Dustin
    Department of Pathology and Center for Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 94:667-77. 1998
  9. ncbi Association of CD2 and CD45 on human T lymphocytes
    B Schraven
    Abteilung Angewandte Immunologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Nature 345:71-4. 1990
  10. ncbi Protein recognition by cell surface receptors: physiological receptors versus virus interactions
    Jia huai Wang
    Dana Farber Cancer Institute, Dept Pediatrics, Harvard Medical School, Room SM 1036B, 44 Binney St, Boston, MA 02115, USA
    Trends Biochem Sci 27:122-6. 2002

Detail Information

Publications156 found, 100 shown here

  1. ncbi Regulation of the interferon-inducible p53 target gene TRIM22 (Staf50) in human T lymphocyte activation
    Susanna Obad
    Department of Haematology and Transfusion Medicine, Lund University, S 221 84 Lund, Sweden
    J Interferon Cytokine Res 27:857-64. 2007
    ..TRIM22 probably has an activation stage-specific role connected to the paracrine crosstalk during T lymphocyte activation...
  2. ncbi DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing
    Alexander Saveliev
    CSC Gene Control Mechanisms and Disease Group, Experimental Genetics, Faculty of Medicine, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 422:909-13. 2003
    ....
  3. ncbi The CD2 family of natural killer cell receptors
    M E McNerney
    Department of Pathology, Committee on Immunology, University of Chicago, 5841 S Maryland Ave, S 315 MC3083, Chicago, IL 60637, USA
    Curr Top Microbiol Immunol 298:91-120. 2006
    ..This review discusses these multiple roles for CD2 family members, focusing specifically on the regulation of NK cells...
  4. pmc Analysis of the immune response to Mycobacterium avium subsp. paratuberculosis in experimentally infected calves
    Hye Cheong Koo
    Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Infect Immun 72:6870-83. 2004
    ..The studies clearly show multicolor FC offers a consistent reliable way to monitor the evolution and changes in the immune response to M. avium subsp. paratuberculosis that occur during disease progression...
  5. ncbi CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells
    S J Teh
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    Blood 89:1308-18. 1997
    ..Furthermore, the results highlight the potential for a differential role for CD2 in thymocyte selection and T-cell immune responses...
  6. pmc The mature activating natural killer cell immunologic synapse is formed in distinct stages
    Jordan S Orange
    Department of Molecular and Cellular Biology, 7 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:14151-6. 2003
    ..Thus the process of CD2, CD11a, CD11b, and F-actin accumulation in the pSMAC and perforin accumulation in the central SMAC of the NKIS are sequential processes with distinct cytoskeletal requirements...
  7. ncbi Human natural killer cell adhesion molecules. Differential expression after activation and participation in cytolysis
    M J Robertson
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 145:3194-201. 1990
    ..These studies suggest that CAM play a central role in the regulation of NK cytolysis, and that changes in CAM expression may alter the target cell specificity of activated NK effectors...
  8. ncbi A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts
    M L Dustin
    Department of Pathology and Center for Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 94:667-77. 1998
    ..This novel protein, called CD2AP, is likely to facilitate receptor patterning in the contact area by linking specific adhesion receptors to the cytoskeleton...
  9. ncbi Association of CD2 and CD45 on human T lymphocytes
    B Schraven
    Abteilung Angewandte Immunologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Nature 345:71-4. 1990
    ..Using chemical crosslinking techniques, we now show that CD45 is linked to CD2 on the surface of human T lymphocytes...
  10. ncbi Protein recognition by cell surface receptors: physiological receptors versus virus interactions
    Jia huai Wang
    Dana Farber Cancer Institute, Dept Pediatrics, Harvard Medical School, Room SM 1036B, 44 Binney St, Boston, MA 02115, USA
    Trends Biochem Sci 27:122-6. 2002
    ..Viruses might take advantage of this low affinity to invade a host cell by evolving a stronger binding affinity to the surface receptors than that associated with physiological ligands. Structural data appear to support this notion...
  11. ncbi Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85
    Nicholas J Hutchings
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 278:22396-403. 2003
    ..These adaptor proteins are important in T cell signaling consistent with a role for CD2 in regulating pathways initiated by CMS/CIN85 and CAPZ...
  12. pmc A feline CD2 homologue interacts with human red blood cells
    Masayuki Shimojima
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Immunology 105:360-6. 2002
    ..These results are indicative of the similarity of feline and human CD2 structures. fCD2 was found to be expressed in feline peripheral blood T lymphocytes, monocytes and cultured lymphoid cells...
  13. ncbi A novel, rapid and sensitive heterotypic cell adhesion assay for CD2-CD58 interaction, and its application for testing inhibitory peptides
    Jining Liu
    Department of Pharmacy, 18 Science Drive 4, National University of Singapore, Singapore 117543, Singapore
    J Immunol Methods 291:39-49. 2004
    ..This method was successfully applied for testing inhibitory peptides to CD2-CD58 interaction...
  14. ncbi Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation
    M P Martelli
    Laboratory of Lymphocyte Biology, National Heart, Lung, and Blood Institute, Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Blood 96:2181-90. 2000
    ..These data suggest that LAT is an adapter protein important for the regulation of CD2-mediated T-cell activation...
  15. pmc The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2
    G M Bell
    Department of Medicine, Veterans Affairs Medical Center, San Francisco, California, USA
    J Exp Med 183:169-78. 1996
    ..Thus, proline-rich sequences in the cytoplasmic domain of CD2 allow this transmembrane receptor to bind to the SH3 domain of p56lck...
  16. ncbi Comparative microarray analysis of gene expression during activation of human peripheral blood T cells and leukemic Jurkat T cells
    Zhaosheng Lin
    Department of Pathology, ARUP Institute for Clinical and Experimental Pathology, University of Utah, Salt Lake City, Utah 84132, USA
    Lab Invest 83:765-76. 2003
    ....
  17. pmc CD2 sets quantitative thresholds in T cell activation
    M F Bachmann
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 190:1383-92. 1999
    ..Thus, CD2 sets quantitative thresholds and fine-tunes T cell activation both in vitro and in vivo...
  18. ncbi Molecular interactions mediating T cell antigen recognition
    P Anton van der Merwe
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Annu Rev Immunol 21:659-84. 2003
    ..These studies provide the necessary framework for exploring how these molecular interactions initiate T cell activation...
  19. ncbi Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors
    J H Wang
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 97:791-803. 1999
    ..These features explain CD2-CD58 dynamic binding, offering insights into interactions of related immunoglobulin superfamily receptors...
  20. pmc Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation
    K Nishizawa
    Laboratory of Immunobiology, Dana Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:14897-902. 1998
    ..Hence, a proline-binding module distinct from SH3 and WW domains regulates protein-protein interactions...
  21. pmc A genomics approach to the detection of positive selection in cattle: adaptive evolution of the T-cell and natural killer cell-surface protein CD2
    David J Lynn
    Department of Genetics, Smurfit Institute, Trinity College, Dublin 2, Ireland
    Genetics 170:1189-96. 2005
    ..Moreover, we show that selection has operated primarily on the extracellular domain of CD2 and discuss the implications of this for an important regulator of the adaptive immune response...
  22. pmc Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells
    Adam D Douglass
    The Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94107, USA
    Cell 121:937-50. 2005
    ..Our data suggest that diffusional trapping through protein-protein interactions creates microdomains that concentrate or exclude cell surface proteins to facilitate T cell signaling...
  23. ncbi CD2 and the nature of protein interactions mediating cell-cell recognition
    S J Davis
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK
    Immunol Rev 163:217-36. 1998
    ..The crystallographic analysis of the CD2-binding domain of CD58 strongly supports this concept...
  24. pmc The structure of the human CD2 gene and its expression in transgenic mice
    G Lang
    Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK
    EMBO J 7:1675-82. 1988
    ....
  25. pmc Bovine CD2-/NKp46+ cells are fully functional natural killer cells with a high activation status
    Preben Boysen
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P, O, Box 8146 Dep, N 0033 Oslo, Norway
    BMC Immunol 7:10. 2006
    ..NK cells are known as a heterogeneous cell group, and we here report the first functional study of bovine NK cell subsets, based on the expression of CD2...
  26. ncbi Porcine CD58: cDNA cloning and molecular dissection of the porcine CD58-human CD2 interface
    Angélique Brossay
    EA 3249 Cellules Hématopoïétiques, Hémostase et Greffe, Universite Francois Rabelais, Tours, France
    Biochem Biophys Res Commun 309:992-8. 2003
    ..These structural data will help us to develop poCD58 blocking agents for xenotransplantation...
  27. ncbi Inhibition of Rho at different stages of thymocyte development gives different perspectives on Rho function
    S Cleverley
    Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Curr Biol 9:657-60. 1999
    ....
  28. pmc CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation
    K Kato
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Exp Med 176:1241-9. 1992
    ..These results indicate that CD48 is a ligand for mouse CD2 and is involved in regulating T cell activation...
  29. ncbi Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59
    W C Hahn
    Division of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA
    Science 256:1805-7. 1992
    ..These observations suggest that direct interactions between CD2 and both CD58 and CD59 contribute to T cell activation and adhesion...
  30. ncbi Coordinate regulation of T cell activation by CD2 and CD28
    J M Green
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 164:3591-5. 2000
    ..This suggests that CD2 and CD28 may function together to facilitate interactions of the T cell and APC, allowing for efficient signal transduction through the TCR...
  31. pmc Development and function of T cells in mice with a disrupted CD2 gene
    N Killeen
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0414
    EMBO J 11:4329-36. 1992
    ..Within the context of other targetted mutations, these mice should be useful in defining the precise roles of various cell surface molecules involved in T cell responses...
  32. ncbi Immunological synapses are versatile structures enabling selective T cell polarization
    David Depoil
    INSERM U563, Lymphocyte Interaction Group, Institut Claude de Preval, 31059 Toulouse
    Immunity 22:185-94. 2005
    ..The combination of sustained signaling with preferential and rapid polarization provides a mechanism for the high sensitivity and selectivity of T cell responses...
  33. ncbi Adhesive bond dynamics in contacts between T lymphocytes and glass-supported planar bilayers reconstituted with the immunoglobulin-related adhesion molecule CD58
    M L Dustin
    Center for Immunology and the Department of Pathology, Washington University School of Medicine, Box 8118, St Louis, Missouri 63110, USA
    J Biol Chem 272:15782-8. 1997
    ..These findings have implications for the mechanism of signaling by CD2 and the mechanism of cell detachment from large numbers of transient interactions...
  34. ncbi Activation marker expression on bovine peripheral blood gammadelta T cells during post-natal development and following vaccination with a commercial polyvalent viral vaccine
    B Vesosky
    Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Dev Comp Immunol 27:439-47. 2003
    ....
  35. pmc Genomewide trapping of genes that encode secreted and transmembrane proteins repressed by oncogenic signaling
    M Gebauer
    ASTA Medica AG, Department of Cancer Research, University of Frankfurt Medical School, Frankfurt am Main, Germany
    Genome Res 11:1871-7. 2001
    ..Molecular analysis of six randomly chosen integrations revealed that, in each case, U3Ceo captured a signal sequence from proteins involved in oncogenic transformation and metastatic spread...
  36. ncbi A critical role for CD2 in both thymic selection events and mature T cell function
    T Sasada
    Laboratory of Immunobiology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:2394-403. 2001
    ..Collectively, these findings show that CD2 plays a role in pre-TCR function in double-negative thymocytes, TCR selection events during thymocyte development, and TCR-stimulated cytokine production in mature T cells...
  37. ncbi Human peripheral CD2-/lo T cells: an extrathymic population of early differentiated, developing T cells
    Matthew J Loza
    Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, BLSB 750, 233 South, 10th Street, Philadelphia, PA 19107, USA
    Int Immunol 17:1213-25. 2005
    ....
  38. ncbi Analysis of human and primate CD2 molecules by protein sequence and epitope mapping with anti-human CD2 antibodies
    Melissa M Damschroder
    Protein Engineering Department, MedImmune Inc, One MedImmune Way, Gaithersburg, MD 20878, USA
    Mol Immunol 41:985-1000. 2004
    ....
  39. ncbi CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus
    C F Evans
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037
    J Immunol 151:6259-64. 1993
    ..Our results indicate that CD2 is not required for the generation of an LCMV-specific CTL response in vivo, nor is CD2 required for the maintenance or activation of memory CTL...
  40. ncbi Study of the physical meaning of the binding parameters involved in effector-target conjugation using monoclonal antibodies against adhesion molecules and cholera toxin
    Pilar García-Peñarrubia
    Department of Biochemistry and Molecular Biology B and Immunology, School of Medicine, 30100 Espinardo, Murcia, Spain
    Cell Immunol 215:141-50. 2002
    ....
  41. ncbi Sheep form of leucocyte function antigen-3 (T11TS) exerts immunostimulatory and anti-tumor activity against experimental brain tumor. A new approach to biological response modifier therapy
    S Sarkar
    Dept of Physiology, University College of Medicine, Kolkata, India
    J Exp Clin Cancer Res 21:95-106. 2002
    ....
  42. pmc CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance
    Elena V Tibaldi
    Laboratory of Immunobiology, Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:7582-7. 2002
    ..This "presynapse" formation on primed T cells will likely facilitate the antigen-dependent recognition capability required for efficient immune surveillance...
  43. ncbi Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion
    De Min Zhu
    Departments of Biological Chemistry and Molecular Pharmacology, Surgery, and Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    ACS Chem Biol 1:649-58. 2006
    ..Subsequently, T cell activation causes the CD58-bound CD2 to be recognized and immobilized at sites of cell-cell contact, thereby strengthening T cell-APC adhesion...
  44. ncbi Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells
    Antonio J da Silva
    Biogen, Inc, Cambridge, MA 02142, USA
    J Immunol 168:4462-71. 2002
    ..Thus alefacept acts as an effector molecule, mediating cognate interactions to activate Fc gamma R(+) cells (e.g., NK cells) to induce apoptosis of sensitive CD2(+) target cells...
  45. doi Impaired interleukin-2 synthesis and T cell proliferation following antibody-mediated CD3 and CD2 or CD28 cross-linking in trans: evidence that T cell activation requires the engagement of costimulatory molecules within the immunological synapse
    Carrie L Watson
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Immunol Invest 37:63-78. 2008
    ....
  46. ncbi High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells
    Holger Karsunky
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Virchowstrasse 173, D 45122 Essen, Germany
    Oncogene 21:1571-9. 2002
    ..These findings suggest that Gfi-1 contributes to T-cell lymphomagenesis by overriding a late G1 cell cycle checkpoint which controls activation induced death and S phase entry of T-cells...
  47. ncbi Increased incidence of EBV-associated lymphoproliferative disorders after allogeneic stem cell transplantation from matched unrelated donors due to a change of T cell depletion technique
    E Meijer
    Department of Hematology, University Medical Centre, Utrecht, The Netherlands
    Bone Marrow Transplant 29:335-9. 2002
    ..Without B cell depletion (CD2/3) this occurred in five out of seven patients (71%) (P < 0.05). A T/B cell ratio in the graft of > or = 0.25 seems sufficient to significantly reduce the incidence of EBV-LPD after BMT from MUDs...
  48. doi Blockade of CD11a by efalizumab in psoriasis patients induces a unique state of T-cell hyporesponsiveness
    Emma Guttman-Yassky
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10065, USA
    J Invest Dermatol 128:1182-91. 2008
    ..The nature of this T-cell hyporesponsiveness suggests that T-cell responses may be reduced during efalizumab therapy, but are reversible after ceasing efalizumab treatment...
  49. ncbi Superantigen presentation by human retinal pigment epithelial cells to T cells is dependent on CD2-CD58 and CD18-CD54 molecule interactions
    A Jørgensen
    Institute of Medical Anatomy, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Exp Eye Res 73:723-33. 2001
    ..The findings thus suggest that also presentation of peptides to resting T cells by RPE cells may be dependent upon these interactions...
  50. ncbi In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern
    Nicolas Blanchard
    INSERM U520, Institut Curie, 12 rue Lhomond, 75005 Paris, France
    Immunity 17:389-99. 2002
    ..In contrast, ZAP-70 is not required for clustering of zeta-GFP and CD2 or exclusion of CD45 and CD43 from the synapse. These data show that ZAP-70-dependent signaling is required for formation of a functional immune synapse...
  51. ncbi The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse
    Karen Badour
    Department of Medical Genetics and Microbiology, University of Toronto, 600 University Avenue, Toronto, M5G 1X5 Ontario, Canada
    Immunity 18:141-54. 2003
    ....
  52. pmc Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal
    David L Tamang
    Department of Microbiology and Immunology 320, University of Nevada, Reno, 1664 N Virginia St Reno, NV 89557, USA
    Cytokine 36:148-59. 2006
    ..Our results suggest that high concentrations of either IL-2 or IL-15 will activate the lytic capacity and granzyme B expression of many T cells and that antigen recognition is not required...
  53. ncbi Intrinsic defects explain altered proliferative responses of T lymphocytes and HVS-derived T-cell lines in gastric adenocarcinoma
    A P Valeri
    Inmunologia, Facultad de Medicina, Universidad Complutense de Madrid, Pabellon 5, 4 feminine planta, 28040 Madrid, Spain
    Cancer Immunol Immunother 52:708-14. 2003
    ....
  54. ncbi CD2-CD48 interactions promote cytotoxic T lymphocyte induction and function: anti-CD2 and anti-CD48 antibodies impair cytokine synthesis, proliferation, target recognition/adhesion, and cytotoxicity
    Bruce L Musgrave
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    J Interferon Cytokine Res 23:67-81. 2003
    ..We conclude that CD2-CD48 interactions during T cell activation are critical for the synthesis of sufficient IL-2 and IFN-gamma to drive CD8(+) T cells to differentiate into functional cytotoxic effector cells...
  55. ncbi CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse
    Nicolas Espagnolle
    INSERM U563, Lymphocyte Interaction Group, Institut Claude de Preval, CHU Purpan, 31059 Toulouse, France
    Int Immunol 19:239-48. 2007
    ..Our results indicate that TCR- and CD2-derived signals converge for the recruitment and activation of PLCgamma1 at the IS and shed new light on the accessory function of CD2 in T cell activation by specific antigen...
  56. pmc The contribution of conformational adjustments and long-range electrostatic forces to the CD2/CD58 interaction
    Alice Kearney
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Biol Chem 282:13160-6. 2007
    ....
  57. ncbi Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways
    Jared J Butler
    Department of Microbiology and Immunology, Faculty of Medicine, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Cell Biochem 89:975-91. 2003
    ..We conclude that adenosine interferes with IL-2-dependent T cell expression of co-stimulatory molecules via a mechanism that does not involve the accumulation of intracellular cAMP...
  58. ncbi NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family
    Erhu Cao
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Immunity 25:559-70. 2006
    ....
  59. ncbi [Lymphocyte populations and subpopulations in peripheral blood of pregnant women with pre-eclampsia]
    E Dimitrakova-Dzhambazova
    Akush Ginekol (Sofiia) 44:40-4. 2005
    ..To investigate the changes of lymphocyte populations and subpopulations in peripheral blood of pregnant women suffering preeclampsia...
  60. ncbi IL-2-activated CD8+CD44high cells express both adaptive and innate immune system receptors and demonstrate specificity for syngeneic tumor cells
    Salim Dhanji
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 171:3442-50. 2003
    ....
  61. pmc A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse
    Kentner Singleton
    Center for Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Immunol 177:4402-13. 2006
    ..Based on this characterization, we speculate that the T cell invagination, aided by CD2 enrichment, internalizes parts of the TCR signaling machinery to reset T cell signaling upon agonist-mediated, stable APC contact...
  62. ncbi NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions
    Erika Assarsson
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    J Immunol 173:174-80. 2004
    ....
  63. ncbi Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion
    Michael L Dustin
    Department of Pathology, New York University School of Medicine and Helen L and Martin S Kimmel Center for Biology and Medicine of Skirball Institute of Biomolecular Medicine, New York, New York 10016, USA
    J Biol Chem 282:34748-57. 2007
    ..These results suggest that additional information is needed to correctly predict Alefacept-mediated bridge formation...
  64. ncbi The nature of molecular recognition by T cells
    Simon J Davis
    Nuffield Department of Clinical Medicine, Weatherall Institute of Molecular Medicine, The University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Nat Immunol 4:217-24. 2003
    ..Here we review these developments and highlight the major challenges remaining as the field moves toward formulating quantitative models of T cell recognition...
  65. ncbi Immunophenotypic analysis of peripheral T-cell neoplasms. A multiparameter flow cytometric approach
    S Jamal
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9073, USA
    Am J Clin Pathol 116:512-26. 2001
    ..These data indicate that most PTCNs are aberrant by multiparameter flow analysis. However, results must be interpreted within the context of thorough knowledge of the immunophenotypic spectrum of nonneoplastic T cells...
  66. ncbi Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness
    M Subramanyam
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111
    J Immunol 150:2544-53. 1993
    ..These results suggest that DP IV is necessary for amplification of signals generated by the engagement of the TCR-CD3 complex by nominal Ag...
  67. ncbi The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation
    H Lin
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int Immunol 13:13-22. 2001
    ..Nevertheless, ZAP-70 kinase was required for CD2-mediated NF-AT transcriptional activity. Thus, CD2-mediated NF-AT transcriptional activity appears to depend upon ZAP-70/Syk kinases and to be negatively regulated by c-Cbl...
  68. ncbi HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism
    B Hofmann
    Center for Interdisciplinary Research in Immunology and Disease CIRID, UCLA School of Medicine
    J Immunol 145:3699-705. 1990
    ..Reduced availability of DAG presumably interferes with pkC activation and leads to decreased expression of receptors for IL-2 and transferrin and impaired proliferation...
  69. ncbi Signalling in human tumour infiltrating lymphocytes: the CD28 molecule is functional and is physically associated with the CD45R0 molecule
    M R Zocchi
    Lab Immunoterapia Adottiva, Istituto Scientifico San Raffaele, Milano, Italy
    Eur J Cancer 28:749-54. 1992
    ..Thus CD28 can substitute for CD3 in TIL leading to the expansion of functional lymphocytes and to the amplification of antitumour immune response...
  70. ncbi Regulation of CD2-mediated heterotypic interactions of murine T lymphocytes
    D Abraham
    Cell Enzymology Unit, Kennedy Institute of Rheumatology, Bute Gardens, London, United Kingdom
    Cell Immunol 156:342-56. 1994
    ....
  71. pmc A subtle role for CD2 in T cell antigen recognition
    P A van der Merwe
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Exp Med 190:1371-4. 1999
  72. ncbi CD2 and CD3 associate independently with CD5 and differentially regulate signaling through CD5 in Jurkat T cells
    A M Carmo
    Laboratório de Imunologia Molecular, Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal
    J Immunol 163:4238-45. 1999
    ..The modulation of CD5 phosphorylation may thus represent a level of regulation controlled by CD2 in signal transduction mechanisms in human T lymphocytes...
  73. ncbi An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex
    A L Luzzati
    Department of Immunology, Istituto Superiore di Sanita, Rome, Italy
    Cell Immunol 156:286-95. 1994
    ....
  74. ncbi Expression and function of lymphocyte function associated antigen-3 (LFA-3) at the blood-brain barrier
    K I Omari
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital, British Columbia, Canada
    Cell Mol Biol (Noisy-le-grand) 45:25-35. 1999
    ..The ability of the cerebral endothelium to express LFA-3 and provide secondary signals for T-cell proliferation suggests that cerebral EC may be important in the initiation of inflammatory responses in the human central nervous system...
  75. pmc Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors
    S Wee
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
    J Exp Med 177:219-23. 1993
    ....
  76. ncbi The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer
    D Wotton
    Imperial Cancer Research Fund, London, United Kingdom
    J Biol Chem 270:7515-22. 1995
    ..Consistent with this result, we show that the observed increase in expression of CD2 protein on the cell surface following T cell activation is a post-transcriptional event...
  77. ncbi Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase
    L E Samelson
    Cell Biology and Metabolism Branch, National Institutes of Child Health and Human Development, Bethesda, MD 20892
    J Immunol 145:2448-54. 1990
    ....
  78. ncbi Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity
    A Poggi
    Istituto Nazionale per la Ricerca sul Cancro e Centro Biotecnologie Avanzate, Genova, Italy
    Eur J Immunol 26:1266-72. 1996
    ..Thus, we propose that NKRP1A molecules, which are expressed in highly immature thymocytes, may play a regulatory role in their growth and function...
  79. ncbi Regulation of the association between PSTPIP and CD2 in murine T cells
    Y Bai
    Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
    Exp Mol Pathol 71:115-24. 2001
    ..PSTPIP likely has additional broader effects through interactions with CD4, CD8, CD54, and CD62L, and this may influence T cell responses to antigen...
  80. ncbi CD59 and CD48 expressed by rat retinal pigment epithelial cells are major ligands for the CD2-mediated alternative pathway of T cell activation
    J Liversidge
    Department of Ophthalmology, University of Aberdeen Medical School, Scotland, United Kingdom
    J Immunol 156:3696-703. 1996
    ....
  81. ncbi The distribution of the CDW52 molecule on blood cells and characterization of its involvement in T cell activation
    H Valentin
    INSERM U343, Hopital de l Archet, Nice, France
    Transplantation 54:97-104. 1992
    ..This is similar to the effects obtained with the CD45R (2H4) mAb, 2H4 and CAMPATH-1M mAb having additive effects on T cell activation via CD2...
  82. ncbi Association of CD2 with tubulin. Evidence for a role of the cytoskeleton in T cell activation
    R Offringa
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts
    J Biol Chem 268:4979-88. 1993
    ....
  83. ncbi Ethanol-induced CD3 and CD2 hyporesponsiveness of peripheral blood T lymphocytes
    F Spinozzi
    Department of Internal Medicine, University of Perugia, Italy
    Immunopharmacol Immunotoxicol 14:939-53. 1992
    ..These data clearly indicate that a membrane-specific ethanol interaction both modifies surface glycoproteic and/or glycolipidic structures and alters transmembrane transduction of the activation signals...
  84. ncbi Dynamic recruitment of human CD2 into lipid rafts. Linkage to T cell signal transduction
    H Yang
    Laboratory of Immunobiology, Dana Farber Cancer Institute and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:18775-85. 2001
    ....
  85. ncbi Multiple co-stimulatory signals are required for triggering proliferation of T cells from human secondary lymphoid tissue
    S G Agrawal
    Department of Immunology, Henri Mondor Hospital, , France
    Int Immunol 13:441-50. 2001
    ..Clearly, LT-T do not behave in a comparable way to PB-T and in vitro experiments assessing novel cancer vaccines should therefore use LT-T as the most appropriate population of responder T cells...
  86. ncbi Aberrant expression of T-cell-associated antigens on B-cell non-Hodgkin lymphomas
    Z Kaleem
    Lauren V. Ackerman Laboratory of Surgical Pathology, Barnes-Jewish Hospital/Washington University Medical Center, St Louis, MO, USA
    Am J Clin Pathol 115:396-403. 2001
    ..Unless aggressive behavior is noted consistently, no aggressive treatment is justified...
  87. ncbi 1F7 (CD26): a marker of thymic maturation involved in the differential regulation of the CD3 and CD2 pathways of human thymocyte activation
    N H Dang
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 147:2825-32. 1991
    ....
  88. pmc Multiple binding sites for melatonin on Kv1.3
    Z Varga
    Department of Biophysics and Cell Biology, University Medical School of Debrecen, Debrecen H-4012, Hungary
    Biophys J 80:1280-97. 2001
    ..However, binding of tetraethylammonium to its receptor decreases the melatonin affinity, and vice versa. Thus, the occupancy of the two separate receptor sites allosterically modulates each other...
  89. pmc The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line
    G M Bell
    Arthritis Immunology Section, Veterans Affairs Medical Center, San Francisco, California
    J Exp Med 175:527-36. 1992
    ..Peptide mapping and reprecipitation studies indicate that the coprecipitating molecule is CD2. Thus, the OX-44 molecule can couple to multiple signaling pathways and associates with CD2 on both RNK-16 and rat T cells...
  90. ncbi T cell hypofunctions and glomerular sclerotic and angiogenic changes found both in rats received unilateral nephrectomy plus transplantation of syngeneic mesenteric lymph nodes and in rats received unilateral nephrectomy plus splenectomy
    T Nakatsuji
    Department of Transfusion, Hamamatsu University School of Medicine, Japan
    Tohoku J Exp Med 186:1-11. 1998
    ..Glomerular angiogenesis and accompanying endothelial cell apoptosis were demonstrated without mesangial cell proliferation in the males with unilateral nephrectomy plus splenectomy...
  91. ncbi Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma
    Andreas Chott
    Department of Pathology, University of Vienna, Vienna, Austria
    Am J Surg Pathol 27:1013-9. 2003
    ..Together, neoplastic mast cells in a case of mast cell sarcoma were found to exhibit unique morphologic, phenotypical, and molecular features when compared with mast cells in indolent mastocytosis or normal tissue mast cells...
  92. pmc Regulatory effect of interleukin-4 (IL-4) on the expression and function of lymphocyte adhesion receptors involved in IL-2-induced cell aggregation
    F A Vyth Dreese
    Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam
    Immunology 78:244-51. 1993
    ..Therefore, rIL-4 appears to inhibit the early phase of rIL-2-induced aggregation by preventing the up-regulation of CD54 and CD2 antigens and by inhibiting the generation of the activated state of the CD11a/CD18 receptor.
  93. ncbi Etiologic and immunologic characteristics of thoroughbred horses with bacterial infectious upper respiratory disease at the Seoul Race Park
    Seung Ho Ryu
    Korea Racing Authority, Gwacheon, Gyeonggi 427 711, Korea
    J Microbiol Biotechnol 19:1041-50. 2009
    ..equi subsp. equi) by preventing the access of infected horses with a respiratory pathogen-free certification system prior to Park entry...
  94. ncbi Immunophenotypic analysis of mast cells in mastocytosis: When and how to do it. Proposals of the Spanish Network on Mastocytosis (REMA)
    Luis Escribano
    Unidad de Mastocitosis, Servicio de Hematología and Laboratorio K Frank Austen, Hospital Ramon y Cajal, Madrid, Spain
    Cytometry B Clin Cytom 58:1-8. 2004
    ....
  95. pmc Blood and milk cellular immune responses of mastitic non-periparturient cows inoculated with Staphylococcus aureus
    A L Rivas
    Department of Population Medicine and Diagnostic Science, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Can J Vet Res 66:125-31. 2002
    ....
  96. ncbi Identification of novel proteins induced by estradiol, 4-hydroxytamoxifen and acolbifene in T47D breast cancer cells
    Mariam H Al-Dhaheri
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, OH, USA
    Steroids 71:966-78. 2006
    ..These novel SERM-regulated proteins may participate in new or existing pathways for sensitivity or resistance to SERMs...
  97. ncbi Lymphocyte development in fetal piglets: facts and surprises
    Marek Sinkora
    Department of Immunology and Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, Doly 183, 549 22 Novy Hradek, Czech Republic
    Vet Immunol Immunopathol 108:177-84. 2005
    ..Therefore, swine present an example of two highly related receptor systems that have diverged in the same species...
  98. ncbi Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)
    A Peterson
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Nature 329:842-6. 1987
    ..CD2 sequences that participate in LFA-3 binding correspond to immunoglobulin variable region hypervariable sequences when the homologous domains are aligned...
  99. pmc Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48
    J G Cabrero
    Department of Pathology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 90:3418-22. 1993
    ..The results of the present report, together with our previous functional studies, may have implications for the role of CD2 and CD48 in murine T-cell activation...
  100. ncbi The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2
    W A Sewell
    Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, UK
    Immunogenetics 28:278-82. 1988
    ..These genes therefore represent a further instance in which related members of the immunoglobulin superfamily are located in adjacent regions of the genome...
  101. pmc Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells
    H Yagita
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Proc Natl Acad Sci U S A 86:645-9. 1989
    ..An unexpected expression of CD2 on murine B cells was revealed by immunofluorescence and immunoprecipitation studies with these monoclonal antibodies and by RNA blot analysis for the murine CD2 transcript...

Research Grants77

  1. Gamma Delta T Cells--Immunotherapy for Melanoma
    Richard Lopez; Fiscal Year: 2003
    ..These findings may provide the basis for the rational design of future immunotherapy trials for the treatment of melanoma or other malignancies. ..
  2. Gamma Delta T Cells--Immunotherapy for Melanoma
    Richard Lopez; Fiscal Year: 2004
    ..These findings may provide the basis for the rational design of future immunotherapy trials for the treatment of melanoma or other malignancies. ..
  3. Design of Ca2+ Sensors to Monitor Ca2+ Signaling in ER
    Jenny Yang; Fiscal Year: 2005
    ....
  4. Gamma Delta T Cells--Immunotherapy for Melanoma
    Richard Lopez; Fiscal Year: 2003
    ..These findings may provide the basis for the rational design of future immunotherapy trials for the treatment of melanoma or other malignancies. ..
  5. Gamma Delta T Cells--Immunotherapy for Melanoma
    Richard Lopez; Fiscal Year: 2002
    ..These findings may provide the basis for the rational design of future immunotherapy trials for the treatment of melanoma or other malignancies. ..
  6. Structural Biology of receptor-mediated extracellular calcium signaling
    Jenny Yang; Fiscal Year: 2007
    ..Our success in designing and engineering metal-binding sites into arbitrary proteins could also lead to new ways of developing valuable reagents for diagnostic tests and chemotherapy. ..
  7. Designing Magnetic Resonance Protein-based Contrast Agents with High Relaxivity
    Jenny Yang; Fiscal Year: 2007
    ..Our proposed work explores a new mechanism to overcome a major limitation of low sensitivity and selectivity of contrast agents facilitating diagnosis and monitoring treatment of various diseases by MRI. ..
  8. Designing Magnetic Resonance Protein-based Contrast Agents with High Relaxivity
    Jenny Yang; Fiscal Year: 2007
    ..Our proposed work explores a new mechanism to overcome a major limitation of low sensitivity and selectivity of contrast agents facilitating diagnosis and monitoring treatment of various diseases byMRI. ..
  9. MHCL RESTRICTED TCR RECOGNITION--STRUCTURAL BASIS
    Jia huai Wang; Fiscal Year: 2002
    ..This should establish whether the docking mode is fixed or variable and whether there are restricted interactions between specific CDRs and MHC versus peptide residues. ..
  10. MHCL RESTRICTED TCR RECOGNITION--STRUCTURAL BASIS
    Jia huai Wang; Fiscal Year: 1999
    ..This should establish whether the docking mode is fixed or variable and whether there are restricted interactions between specific CDRs and MHC versus peptide residues. ..
  11. MHCL RESTRICTED TCR RECOGNITION--STRUCTURAL BASIS
    Jia huai Wang; Fiscal Year: 2001
    ..This should establish whether the docking mode is fixed or variable and whether there are restricted interactions between specific CDRs and MHC versus peptide residues. ..
  12. MHCL RESTRICTED TCR RECOGNITION--STRUCTURAL BASIS
    Jia huai Wang; Fiscal Year: 2000
    ..This should establish whether the docking mode is fixed or variable and whether there are restricted interactions between specific CDRs and MHC versus peptide residues. ..
  13. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2006
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. [unreadable] [unreadable]..
  14. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2007
    ..However, the differential resistance is lost in p53"'" mice and in Bcl-2 transgenic mice. We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..
  15. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2007
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. [unreadable] [unreadable]..
  16. Structural Biology of receptor-mediated extracellular calcium signaling
    Jenny Yang; Fiscal Year: 2009
    ..Our success in designing and engineering metal-binding sites into arbitrary proteins could also lead to new ways of developing valuable reagents for diagnostic tests and chemotherapy. ..
  17. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2006
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  18. Biomechanics on Neutrophil Rolling on the Endothelium
    Jin Yu Shao; Fiscal Year: 2006
    ..The microvillus mechanics will be studied with the optical tweezers, combined with the micropipette manipulation system. ..
  19. Mechanisms of Integrin-Mediated Costimulation in T Cells
    Stephen C Bunnell; Fiscal Year: 2010
    ..In this manner, we expect to gain useful insights into the underlying causes of common medical conditions, including asthma, multiple sclerosis, diabetes, inflammatory bowel disease, and atherosclerosis. ..
  20. Rational Design and Analysis of Calcium Binding Protein
    Jenny Yang; Fiscal Year: 2005
    ..A comparison of the calcium binding sites in proteins determined by high-resolution methods with those of the originally designed target will be carried out to optimize our methods for design of calcium ..
  21. Biomechanics on Neutrophil Rolling on the Endothelium
    Jin Yu Shao; Fiscal Year: 2005
    ..The microvillus mechanics will be studied with the optical tweezers, combined with the micropipette manipulation system. ..
  22. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2005
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  23. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2005
    ..abstract_text> ..
  24. Chemokine Receptor Chimeras by Synthetic Gene Library
    Michael Dustin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. MDR Gene Polymorphisms in AML
    Maria Baer; Fiscal Year: 2007
    ..The project is expected to provide important information for use in improving AML treatment stratification and outcomes. [unreadable] [unreadable] [unreadable]..
  26. Mechanisms of Integrin-Mediated Costimulation in T Cells
    STEPHEN BUNNELL; Fiscal Year: 2009
    ..In this manner, we expect to gain useful insights into the underlying causes of common medical conditions, including asthma, multiple sclerosis, diabetes, inflammatory bowel disease, and atherosclerosis. ..
  27. Structural Biology of receptor-mediated extracellular calcium signaling
    Jenny Yang; Fiscal Year: 2008
    ..Our success in designing and engineering metal-binding sites into arbitrary proteins could also lead to new ways of developing valuable reagents for diagnostic tests and chemotherapy. ..
  28. Designing Magnetic Resonance Protein-based Contrast Agents with High Relaxivity
    Jenny Yang; Fiscal Year: 2008
    ..Our proposed work explores a new mechanism to overcome a major limitation of low sensitivity and selectivity of contrast agents facilitating diagnosis and monitoring treatment of various diseases by MRI. ..
  29. Blood Stem Cell Transplantation as Immunotherapy
    Samuel Strober; Fiscal Year: 2008
    ..The administrative and biostatistical core will serve the needs of all projects, and the immune assay and flow cytometry core will service all projects as well. ..
  30. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2007
    ..We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..
  31. Inverted two photon laser scanning microscope for host defense
    Michael Dustin; Fiscal Year: 2008
    ..The impact on public health will be to develop better strategies to fight infections and reduce the incidence of pathogen triggered autoimmunity. [unreadable] [unreadable] [unreadable]..
  32. REQUIREMENT FOR SENSITIVE T CELL RESPONSE TO ANTIGEN
    Michael Dustin; Fiscal Year: 2008
    ..Then we will use RNA interference and overexpression studies to manipulate the balance between the lamellipodium and lemella to determine which of these structures are most important for sensitive antigen recognition. ..
  33. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2008
    ..However, the differential resistance is lost in p53"'" mice and in Bcl-2 transgenic mice. We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..
  34. Designing Magnetic Resonance Protein-based Contrast Agents with High Relaxivity
    Jenny Yang; Fiscal Year: 2009
    ..Our proposed work explores a new mechanism to overcome a major limitation of low sensitivity and selectivity of contrast agents facilitating diagnosis and monitoring treatment of various diseases by MRI. ..
  35. REQUIREMENT FOR SENSITIVE T CELL RESPONSE TO ANTIGEN
    Michael Dustin; Fiscal Year: 2007
    ..Then we will use RNA interference and overexpression studies to manipulate the balance between the lamellipodium and lemella to determine which of these structures are most important for sensitive antigen recognition. ..
  36. Structural Biology of receptor-mediated extracellular calcium signaling
    Jenny Yang; Fiscal Year: 2008
    ..Our success in designing and engineering metal-binding sites into arbitrary proteins could also lead to new ways of developing valuable reagents for diagnostic tests and chemotherapy. ..
  37. Exploring the consequences of the TNFRSF1A susceptibility allele for MS
    Philip L De Jager; Fiscal Year: 2010
    ....
  38. Designing Magnetic Resonance Protein-based Contrast Agents with High Relaxivity
    Jenny J Yang; Fiscal Year: 2010
    ..Our proposed work explores a new mechanism to overcome a major limitation of low sensitivity and selectivity of contrast agents facilitating diagnosis and monitoring treatment of various diseases by MRI. ..
  39. Rational Design and Analysis of Calcium Binding Protein
    Jenny Yang; Fiscal Year: 2004
    ..A comparison of the calcium binding sites in proteins determined by high-resolution methods with those of the originally designed target will be carried out to optimize our methods for design of calcium ..
  40. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2001
    ..GVHD will be monitored by clinical signs, survival, and histopathology. ..
  41. Rational Design and Analysis of Calcium Binding Protein
    Jenny Yang; Fiscal Year: 2001
    ..A comparison of the calcium binding sites in proteins determined by high-resolution methods with those of the originally designed target will be carried out to optimize our methods for design of calcium ..
  42. CD4/CD8/ALPHA BETA T CELLS IN AUTOIMMUNE MICE
    Samuel Strober; Fiscal Year: 2000
    ..The possible role of CD1 molecules as an autoantigen in heredity mouse models of lipus (NZB/NZW) will be explored also by attempting to block spontaneous autoantibody secretion in vitro and in vivo with anti-CD1 antibodies. ..
  43. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2000
    ..Results of this study should help the design of clinical protocols of allogeneic marrow or mobilized blood cell transplantation in attempts to reduce the risks of graft-versus-host disease and recurrent malignancy. ..
  44. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2000
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  45. INTRAEPITHELIAL LYMPHOCYTES RELATION TO EPITHELIAL CELLS
    Ellen Ebert; Fiscal Year: 1992
    ..Human IEL are a little-understood compartment of lymphocytes whose interactions with EC have never been studied. Yet, these interactions may be critical to the mucosal immune network...
  46. CD4/CD8/ALPHA BETA T CELLS IN AUTOIMMUNE MICE
    Samuel Strober; Fiscal Year: 1999
    ..The possible role of CD1 molecules as an autoantigen in heredity mouse models of lipus (NZB/NZW) will be explored also by attempting to block spontaneous autoantibody secretion in vitro and in vivo with anti-CD1 antibodies. ..
  47. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 1999
    ..Finally, the subsets of donor cells which induce tolerance, and subsets of recipient cells which maintain tolerance will be identified in adoptive transfer studies. ..
  48. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2002
    ..GVHD will be monitored by clinical signs, survival, and histopathology. ..
  49. Rational Design and Analysis of Calcium Binding Protein
    Jenny Yang; Fiscal Year: 2002
    ..A comparison of the calcium binding sites in proteins determined by high-resolution methods with those of the originally designed target will be carried out to optimize our methods for design of calcium ..
  50. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2003
    ..GVHD will be monitored by clinical signs, survival, and histopathology. ..
  51. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2004
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  52. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2004
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  53. Biomechanics on Neutrophil Rolling on the Endothelium
    Jin Yu Shao; Fiscal Year: 2003
    ..The microvillus mechanics will be studied with the optical tweezers, combined with the micropipette manipulation system. ..
  54. CD4(-) and CD8(-) T Cells in Autoimmune & Normal Mice
    Samuel Strober; Fiscal Year: 2003
    ..The latter cells will be transferred to non-transgenic NZB/NZW hosts to determine their contribution to IgG autoantibody secretion. ..
  55. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2004
    ..abstract_text> ..
  56. Rational Design and Analysis of Calcium Binding Protein
    Jenny Yang; Fiscal Year: 2002
    ..A comparison of the calcium binding sites in proteins determined by high-resolution methods with those of the originally designed target will be carried out to optimize our methods for design of calcium ..
  57. Rational Design and Analysis of Calcium Binding Protein
    Jenny Yang; Fiscal Year: 2004
    ..A comparison of the calcium binding sites in proteins determined by high-resolution methods with those of the originally designed target will be carried out to optimize our methods for design of calcium ..
  58. Broad Spectrum MDR Modulation in AML
    Maria Baer; Fiscal Year: 2004
    ..The study is expected to provide essential information for the design of future clinical trials of broad-spectrum MDR modulation in AML and other malignancies. ..
  59. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2001
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  60. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2005
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. ..
  61. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2001
    ..Results of this study should help the design of clinical protocols of allogeneic marrow or mobilized blood cell transplantation in attempts to reduce the risks of graft-versus-host disease and recurrent malignancy. ..
  62. Structural Biology of receptor-mediated extracellular calcium signaling
    Jenny Yang; Fiscal Year: 2009
    ..Our success in designing and engineering metal-binding sites into arbitrary proteins could also lead to new ways of developing valuable reagents for diagnostic tests and chemotherapy. ..
  63. Lymphoma Therapy Using Mixed Progenitor Transplants
    Samuel Strober; Fiscal Year: 2004
    ..GVHD will be monitored by clinical signs, survival, and histopathology. ..
  64. Lupus Glomenulonephritis and NK T cells
    Samuel Strober; Fiscal Year: 2009
    ..proposed research studies the interactions between the NK T cells and B cells in the immune tissues and inflamed kidneys that cause autoantibody formation, and studies ways to inhibit the interactions and ameliorate the kidney disease ..
  65. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 1999
    ..Results of this study should help the design of clinical protocols of allogeneic marrow or mobilized blood cell transplantation in attempts to reduce the risks of graft-versus-host disease and recurrent malignancy. ..
  66. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2002
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  67. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2006
    ..abstract_text> ..
  68. MOBILIZED BLOOD STEM CELL TRANSPLANTATION WITHOUT GVHD
    Samuel Strober; Fiscal Year: 2007
    ..abstract_text> ..
  69. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2001
    ..They will also study GVHD using similar hypotheses and models. Mice tolerant of their allografts will be observed for evidence of immune deviation, clonal anergy or deletion, chimerism, and allograft expression of cytokine mRNA. ..
  70. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  71. DONOR CELL FACILITATION OF TOLERANCE
    Samuel Strober; Fiscal Year: 2009
    ..However, the differential resistance is lost in p53"'" mice and in Bcl-2 transgenic mice. We will determine whether the ability to induce tolerance and prevent GVHD is also lost in the latter genetically altered mice. ..