neprilysin

Summary

Summary: Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

Top Publications

  1. pmc In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin
    Hui Huang
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Neurotoxicology 32:300-6. 2011
  2. pmc Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
    Gillian I Rice
    Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Biochem J 383:45-51. 2004
  3. ncbi Metabolic regulation of brain Abeta by neprilysin
    N Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako shi 351 0198 Japan
    Science 292:1550-2. 2001
  4. doi Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses
    Efrat Abramov
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nat Neurosci 12:1567-76. 2009
  5. ncbi Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
    Malcolm A Leissring
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Harvard Medical School, Boston, MA 02115, USA
    Neuron 40:1087-93. 2003
  6. ncbi Neutral endopeptidase protein expression and prognosis in localized prostate cancer
    Iman Osman
    Department of Urology, New York University Cancer Institute, Kaplan Comprehensive Cancer Center, New York, New York, USA
    Clin Cancer Res 10:4096-100. 2004
  7. doi Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer
    Veronique Maguer-Satta
    Universite de Lyon, Lyon, F 69007, France
    Stem Cells 29:389-96. 2011
  8. pmc Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease
    Nikolai D Belyaev
    Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK
    EMBO Rep 10:94-100. 2009
  9. doi Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients
    Manuel D Gahete
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, and Instituto Maimónides de Investigación Biomédica de Córdoba, Cordoba, Spain
    J Alzheimers Dis 20:465-75. 2010
  10. ncbi Identification, proteomic profiling, and origin of ram epididymal fluid exosome-like vesicles
    Jean Luc Gatti
    Equipe Gamètes Males et Fertilité, URM 6175 INRA CNRS Université de TOURS Haras Nationaux, Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique de Nouzilly, Monnaie 37380, France
    Biol Reprod 72:1452-65. 2005

Research Grants

  1. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010
  2. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010
  3. NEUROPEPTIDE DEGRADATION IN THE SMALL INTESTINE
    Nigel Bunnett; Fiscal Year: 1993
  4. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
  5. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2010
  6. Prevention of Diabetic Neuropathy with ACE Inhibitors
    Mark Yorek; Fiscal Year: 2009
  7. INTRARENAL REGULATION OF SODIUM EXCRETION
    John Burnett; Fiscal Year: 2004
  8. NEURAL REGULATION OF PANCREATIC FUNCTION
    Kimberly Kirkwood; Fiscal Year: 2002
  9. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 1999
  10. INTRARENAL REGULATION OF SODIUM EXCRETION
    John Burnett; Fiscal Year: 2000

Detail Information

Publications272 found, 100 shown here

  1. pmc In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin
    Hui Huang
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Neurotoxicology 32:300-6. 2011
    ..b>Neprilysin (NEP), a rate-limiting catabolic peptidase is involved in Aβ metabolism in vivo...
  2. pmc Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
    Gillian I Rice
    Proteolysis Research Group, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Biochem J 383:45-51. 2004
    ..cleavage by full-length human ACE, the separate N- and C-domains of ACE, the homologue of ACE, ACE2, and NEP (neprilysin)...
  3. ncbi Metabolic regulation of brain Abeta by neprilysin
    N Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako shi 351 0198 Japan
    Science 292:1550-2. 2001
    ..We examined the role of neprilysin, a candidate Abeta-degrading peptidase, in the metabolism using neprilysin gene-disrupted mice...
  4. doi Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses
    Efrat Abramov
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nat Neurosci 12:1567-76. 2009
    ....
  5. ncbi Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
    Malcolm A Leissring
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Harvard Medical School, Boston, MA 02115, USA
    Neuron 40:1087-93. 2003
    ..Here we show that transgenic overexpression of insulin-degrading enzyme (IDE) or neprilysin (NEP) in neurons significantly reduces brain Abeta levels, retards or completely prevents amyloid plaque ..
  6. ncbi Neutral endopeptidase protein expression and prognosis in localized prostate cancer
    Iman Osman
    Department of Urology, New York University Cancer Institute, Kaplan Comprehensive Cancer Center, New York, New York, USA
    Clin Cancer Res 10:4096-100. 2004
    ..We investigated whether decreased NEP expression in localized prostate cancers is associated with prostate-specific antigen (PSA) relapse after radical prostatectomy...
  7. doi Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer
    Veronique Maguer-Satta
    Universite de Lyon, Lyon, F 69007, France
    Stem Cells 29:389-96. 2011
    ..This highlights the importance of understanding the role of CD10 in cancer SC. We will review the characteristics, main functions, and mechanism of action of CD10. Finally, we will review its clinical use and involvement in cancer...
  8. pmc Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease
    Nikolai D Belyaev
    Faculty of Biological Sciences, Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK
    EMBO Rep 10:94-100. 2009
    ..domain of the amyloid precursor protein (AICD) regulates expression of the Abeta-degrading metalloprotease, neprilysin (NEP)...
  9. doi Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients
    Manuel D Gahete
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, and Instituto Maimónides de Investigación Biomédica de Córdoba, Cordoba, Spain
    J Alzheimers Dis 20:465-75. 2010
    ..real-time PCR the mRNA levels of SST/CST, their receptors (sst1-5 and DA receptors (drd1-5) in addition to neprilysin (a SST-regulated enzyme involved in Abeta degradation) in three regions of the temporal lobe, one of the ..
  10. ncbi Identification, proteomic profiling, and origin of ram epididymal fluid exosome-like vesicles
    Jean Luc Gatti
    Equipe Gamètes Males et Fertilité, URM 6175 INRA CNRS Université de TOURS Haras Nationaux, Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique de Nouzilly, Monnaie 37380, France
    Biol Reprod 72:1452-65. 2005
    ..proteins were identified and grouped into i) membrane-linked enzymes, such as dipeptidyl peptidase IV (DPP-IV), neprilysin (NEP), phosphodiesterase-I (E-NPP3), and protein G-beta; ii) vesicle-associated proteins, such as lactadherin (..
  11. ncbi Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases
    K Shirotani
    Laboratory for Proteolytic Neuroscience, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 276:21895-901. 2001
    ..1-42-degrading enzyme whose activity is inhibited by thiorphan and phosphoramidon in vivo, we searched for neprilysin (NEP) homologues and cloned neprilysin-like peptidase (NEPLP) alpha, NEPLP beta, and NEPLP gamma cDNAs...
  12. pmc Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice
    Lori Lebson
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 30:9651-8. 2010
    ..weekly infusions of the CD11b+ bone marrow cells transfected with a genetically engineered form of the protease neprilysin completely arrest amyloid deposition in an aggressively depositing transgenic model...
  13. ncbi Metabolism of amyloid-beta peptide and Alzheimer's disease
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Pharmacol Ther 108:129-48. 2005
    ..b>Neprilysin is a rate-limiting peptidase involved in the physiological degradation of Abeta in the brain...
  14. ncbi Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon
    C Oefner
    Pharma Preclinical Research, F Hoffmann La Roche Ltd, Basel, CH 4070, Switzerland
    J Mol Biol 296:341-9. 2000
    ..The inhibitor is bound to one side of this cavity and its binding mode provides a detailed understanding of the ligand-binding and specificity determinants...
  15. ncbi Prognostic impact of germinal center-associated proteins and chromosomal breakpoints in poor-risk diffuse large B-cell lymphoma
    Gustaaf W van Imhoff
    Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Clin Oncol 24:4135-42. 2006
    ....
  16. ncbi Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer
    Stephen J Freedland
    Department of Urology, UCLA School of Medicine, Los Angeles, CA 90095 1738, USA
    Prostate 55:71-80. 2003
    ....
  17. pmc Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice
    William J Meilandt
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
    J Neurosci 29:1977-86. 2009
    ..Overexpression of the Abeta-degrading enzyme neprilysin in brains of human amyloid precursor protein (hAPP) transgenic mice decreases overall Abeta levels and amyloid ..
  18. ncbi Chemosensitization of androgen-independent prostate cancer with neutral endopeptidase
    Makoto Sumitomo
    Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Clin Cancer Res 10:260-6. 2004
    ..We investigated whether neutral endopeptidase (NEP) could augment chemosensitivity to anticancer drugs by promoting protein kinase C (PKC)delta-mediated mitochondrial apoptosis in prostate cancer (PC) cells...
  19. ncbi Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth
    A Horiguchi
    Urologic Oncology Research Laboratory, Department of Urology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cancer Gene Ther 14:583-9. 2007
    b>Neprilysin (neutral endopeptidase, NEP) is a cell surface peptidase whose expression is lost in approximately 50% of prostate cancers (PC)...
  20. doi CD10 and CD34 in fetal and adult human hair follicles: dynamic changes in their immunohistochemical expression during embryogenesis and hair cycling
    E Poblet
    Department of Pathology and AECC Research Unit, Hospital General Universitario de Albacete, Albacete, Spain
    Br J Dermatol 159:646-52. 2008
    ..CD10 and CD34 have been detected in both epithelial and mesenchymal components of anagen human hair follicles...
  21. ncbi Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 24:991-8. 2004
    ..Here, we report on the catabolic mechanism of Abeta at the presynaptic sites. Neprilysin, an Abeta-degrading enzyme, expressed by recombinant adeno-associated viral vector-mediated gene transfer, was ..
  22. pmc Circulating neprilysin clears brain amyloid
    Yinxing Liu
    Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, Lexington, KY 40536 0509, USA
    Mol Cell Neurosci 45:101-7. 2010
    The use of the peptidase neprilysin (NEP) as a therapeutic for lowering brain amyloid burden is receiving increasing attention...
  23. doi Effect of sodium valproate administration on brain neprilysin expression and memory in rats
    Natalia N Nalivaeva
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
    J Mol Neurosci 46:569-77. 2012
    ..In the healthy brain, a group of amyloid-degrading enzymes including neprilysin (NEP) maintain Aβ levels at physiologically low concentrations but, with age and under some pathological ..
  24. ncbi Oxidized neprilysin in aging and Alzheimer's disease brains
    Deng Shun Wang
    Department of Neuroscience and Pathology Neuropathology, Mayo Clinic, Jacksonville, FL 32224, USA
    Biochem Biophys Res Commun 310:236-41. 2003
    ..b>Neprilysin (NEP) is a major enzyme for degradation of Abeta and changes in amount or activity of NEP may play a role in ..
  25. ncbi Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidase
    R Zheng
    Department of Urology, Urologic Oncology Research Laboratory, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10021, USA
    Oncogene 25:5942-52. 2006
    ..This work also identifies members of this signaling pathway as potential targets for rational pharmacologic manipulation of neuropeptide-stimulated migration of PC cells...
  26. pmc Neprilysin, obesity and the metabolic syndrome
    K F Standeven
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Int J Obes (Lond) 35:1031-40. 2011
    b>Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism...
  27. ncbi Availability of CD10 immunohistochemistry as a marker of breast myoepithelial cells on paraffin sections
    Suzuko Moritani
    Department of Pathology, Shiga University of Medical Science, Seta tsukinowa cho, Ohtsu, Japan
    Mod Pathol 15:397-405. 2002
    ..Combination of CD10 and SMA will provide more sophisticated information about presence or absence of myoepithelial cells in confusing breast lesions...
  28. pmc Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt
    Martin Siepmann
    Department of Neurology, Molecular Cell Biology, University of Bonn, Bonn, Germany
    PLoS ONE 5:. 2010
    b>Neprilysin (NEP) is a type II membrane metalloproteinase that cleaves physiologically active peptides at the cell surface thus regulating the local concentration of these peptides available for receptor binding and signal transduction...
  29. pmc Neprilysin-2 is an important β-amyloid degrading enzyme
    Daniel Hafez
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    Am J Pathol 178:306-12. 2011
    ..The Aβ-degrading enzyme neprilysin (NEP) is the best known target of these inhibitors...
  30. ncbi Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?
    Julie A Carson
    Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, UK
    J Neurochem 81:1-8. 2002
    ..Recent attention has focused on members of the neprilysin (NEP) family of zinc metalloproteinases in amyloid metabolism...
  31. doi Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-β42 levels in Lewy body disease
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 22:933-8. 2010
    ..b>Neprilysin (NEP) is an Aβ-degrading protein found at presynaptic terminals and in body fluids...
  32. pmc Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses
    Naoko Morisaki
    Kao Biological Science Laboratories, 2606 Akabane, Ichikaimachi, Haga, Tochigi 321 3497, Japan
    J Biol Chem 285:39819-27. 2010
    ..As there are similarities in the molecular weights and inhibitory profiles of HSF elastase and neprilysin (neutral endopeptidase 24...
  33. ncbi Declining expression of neprilysin in Alzheimer disease vasculature: possible involvement in cerebral amyloid angiopathy
    Mélanie Carpentier
    Departement de Biochimie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    J Neuropathol Exp Neurol 61:849-56. 2002
    Molecular, genetic, and pharmacological studies have shown that neprilysin (also called NEP) catabolizes amyloid beta peptides (A beta) in healthy conditions...
  34. doi Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity
    James Scott Miners
    Dementia Research Group, Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol, United Kingdom
    J Neuropathol Exp Neurol 68:902-14. 2009
    Experimental reduction of neprilysin (NEP) or insulin-degrading enzyme (IDE) in vivo exacerbates beta-amyloid accumulation in the brain...
  35. pmc Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease
    Yinxing Liu
    Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, Lexington, Kentucky, USA
    Mol Ther 17:1381-6. 2009
    b>Neprilysin (NEP) is a zinc metallopeptidase that efficiently degrades the amyloid beta (Abeta) peptides believed to be involved in the etiology of Alzheimer disease (AD)...
  36. pmc Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity
    Petra A B Klemmt
    Nuffield Department of Obstetrics and Gynaecology, The Women s Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Fertil Steril 85:564-72. 2006
    ..To evaluate the phenotype, proliferative, and differentiation capacities in vitro of stromal cells derived from peritoneal, ovarian, and deeply infiltrating endometriosis...
  37. ncbi Neprilysin gene transfer reduces human amyloid pathology in transgenic mice
    Robert A Marr
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:1992-6. 2003
    ..b>Neprilysin has recently been implicated as a major extracellular Abeta degrading enzyme in the brain...
  38. pmc A human postnatal lymphoid progenitor capable of circulating and seeding the thymus
    Emmanuelle M Six
    Institut National de la Sante et de la Recherche Medicale INSERM, U768, 75015 Paris, France
    J Exp Med 204:3085-93. 2007
    ..Moreover, they belong to the most immature thymocyte population. Collectively, these findings unravel the existence of a postnatal lymphoid-polarized population that is capable of migrating from the BM to the thymus...
  39. ncbi Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form
    Hyoe Kanemitsu
    Department of Neuroscience, Graduate School of Medicine Osaka City University, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Neurosci Lett 350:113-6. 2003
    ..Here we studied neprilysin, a putative proteolytic enzyme for Abeta, and found that it degraded not only monomeric but also oligomeric ..
  40. pmc Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain
    Suqing Wang
    Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurochem 115:47-57. 2010
    ..The major Aβ-degrading enzymes are neprilysin (NEP), insulin-degrading enzyme (IDE), and endothelin-converting enzyme (ECE-1)...
  41. doi Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysin
    LingLing Yang
    Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan 250012, Shandong, China
    J Pharm Pharmacol 61:375-80. 2009
    ..Recent evidence has shown that neprilysin (NEP) is the rate-limiting enzyme in the Abeta degradation in the brain. Ginseng, the root of Panax ginseng C.A...
  42. ncbi Utility of CD10 in distinguishing between endometrial stromal sarcoma and uterine smooth muscle tumors: an immunohistochemical comparison of 34 cases
    P G Chu
    Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
    Mod Pathol 14:465-71. 2001
    ..We conclude that in combination with SMA, MSA, and desmin, CD10 is a useful immunohistochemical marker in the differential diagnosis of ESS versus UCL or ULS...
  43. pmc Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease
    Hanjun Guan
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurosci Res 87:1462-73. 2009
    ..a novel strategy for lowering amyloid burden in the brain by peripherally expressing the Abeta-degrading enzyme neprilysin on leukocytes in the 3xTg-AD mouse model of Alzheimer's disease...
  44. pmc CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung
    M A Shipp
    Department of Medicine, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 88:10662-6. 1991
    ..Since SCCa of the lung occurs almost exclusively in cigarette smokers and cigarette smoke inactivates CD10/NEP, decreased cell surface CD10/NEP enzymatic activity may be causally related to the development of SCCa of the lung...
  45. ncbi CD10 is a marker for normal and neoplastic endometrial stromal cells
    Toshihiko Toki
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Int J Gynecol Pathol 21:41-7. 2002
    ..These data suggest that diffuse CD10 staining is characteristic of normal and neoplastic endometrial stromal cells, unless they are decidualized...
  46. ncbi HIV-1 Tat inhibits neprilysin and elevates amyloid beta
    Hans C Rempel
    Department of Laboratory Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    AIDS 19:127-35. 2005
    ..lengthened the life expectancy of individuals infected with HIV-1, we investigated the affect of HIV-1 Tat, a viral transactivating transcription factor, on Abeta degradation in the brain by neprilysin (NEP), a neuronal endopeptidase.
  47. ncbi Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation
    Takashi Saito
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Nat Med 11:434-9. 2005
    ..pathogenic agent of Alzheimer disease, in the brain through modulating proteolytic degradation catalyzed by neprilysin. Among various effector candidates, only somatostatin upregulated neprilysin activity in primary cortical ..
  48. pmc Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling
    M Sumitomo
    Urologic Oncology Research Laboratory, Department of Urology, and Department of Pathology, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 106:1399-407. 2000
    ....
  49. ncbi Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis
    T Ouimet
    Unité de Neurobiologie et Pharmacologie Moléculaire U109 de L INSERM, Centre Paul Broca, 2ter rue d Alesia, Paris, 75014, France
    Biochem Biophys Res Commun 271:565-70. 2000
    ..In brain, NEPII is expressed heterogeneously among several neuronal populations and according to a pattern grossly complementary to that of NEP...
  50. ncbi CD10 expression in stromal cells of oral cavity squamous cell carcinoma: a clinic and pathologic correlation
    A Piattelli
    Dental School, University of Chieti Pescara, Chieti, Italy
    Oral Dis 12:301-4. 2006
    ..CD10 is expressed on the majority of follicle-center lymphomas and Burkitt lymphomas. CD10 has also been shown to be present in a variety of other neoplasms...
  51. ncbi Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons
    Emi Hama
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 279:30259-64. 2004
    b>Neprilysin (NEP) is a rate-limiting amyloid beta peptide (Abeta)-degrading enzyme in the brain...
  52. pmc A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injury
    Victoria E Johnson
    Penn Center for Brain Injury and Repair, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 26:1197-202. 2009
    ..association between amyloid deposition acutely after TBI and a genetic polymorphism of the AB-degrading enzyme, neprilysin (n = 81). We found that the length of the GT repeats in AB-accumulators was longer than in non-accumulators...
  53. doi Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study
    Luis Miguel Ruilope
    Division of Hypertension, Hospital 12 de Octubre, Madrid, Spain
    Lancet 375:1255-66. 2010
    LCZ696 is a first-in-class inhibitor of the angiotensin II receptor and neprilysin. We aimed to establish whether the dual actions of LCZ696 lead to further lowering of blood pressure, compared with the angiotensin-receptor blocker ..
  54. doi Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme
    J Scott Miners
    Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Bristol, UK
    Brain Pathol 20:794-802. 2010
    ..We measured BACE-1 activity and the levels and activities of neprilysin (NEP), insulin-degrading enzyme (IDE) and angiotensin-converting enzyme (ACE) in normal control brains (16 years-..
  55. pmc Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin
    Yvonne S Eisele
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    Mol Biol Cell 18:3591-600. 2007
    ..with the increase in AICD, Gleevec leads to elevated mRNA and protein levels of the Abeta-degrading enzyme neprilysin, a potential target gene of AICD-regulated transcription...
  56. pmc Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase
    Thomas Walther
    Department of Cardiology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    PLoS ONE 4:e4590. 2009
    Neutral endopeptidase, also known as neprilysin and abbreviated NEP, is considered to be one of the key enzymes in initial human amyloid-beta (Abeta) degradation...
  57. ncbi B lymphopoiesis is active throughout human life, but there are developmental age-related changes
    Maria Isabel D Rossi
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Blood 101:576-84. 2003
    ..Dramatic changes in human B lymphopoiesis occur early in life, and more information is required to construct a probable sequence of differentiation events prior to the acquisition of CD10...
  58. ncbi Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain
    Y Takaki
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Biochem 128:897-902. 2000
    ..We analyzed the brain-derived enzyme by means of immuno-depletion and gene disruption, and demonstrate here that neprilysin accounts for the majority of the Abeta-degrading activity...
  59. ncbi Expression of neuropeptide-degrading enzymes in alopecia areata: an immunohistochemical study
    M Toyoda
    Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Br J Dermatol 144:46-54. 2001
    ..However, there has been little substantial evidence of specific participation of cutaneous neurogenic factors in the disease process...
  60. pmc Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia
    Edward C Dempsey
    Cardiovascular Pulmonary Research Laboratory B 133, University of Colorado Denver, 12700 E 19 Ave, Aurora, CO 80046, USA
    Am J Pathol 174:782-96. 2009
    b>Neprilysin is a transmembrane metalloendopeptidase that degrades neuropeptides that are important for both growth and contraction...
  61. ncbi Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels
    E Hellström-Lindahl
    Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Geriatric lab, Novum, Floor 4, S 141 86 Stockholm, Sweden
    Neurobiol Aging 29:210-21. 2008
    ..b>Neprilysin has been shown to be an important enzyme to degrade A beta in brain...
  62. ncbi Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesis
    A Horiguchi
    Urologic Oncology Research Laboratory, Department of Urology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Prostate Cancer Prostatic Dis 11:79-87. 2008
    ..05). Our data suggest that stable expression of NEP in DU145 cells inhibits prostate cancer tumorigenicity by inhibiting angiogenesis, with a probable mechanism being proteolytic inactivation of FGF-2...
  63. doi The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 380:1387-95. 2012
    ..We assessed the efficacy and safety of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), in patients with this disorder.
  64. ncbi Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1
    P Facchinetti
    Unité de Neurobiologie et Pharmacologie Moléculaire U573 de l INSERM, Centre Paul Broca, 2ter rue d Alesia, 75014 Paris, France
    Neuroscience 118:627-39. 2003
    The localisation of the gene transcripts of a recently discovered peptidase, neprilysin 2 (NEP2), was established by in situ hybridisation in rat tissues during development and adulthood...
  65. ncbi CD10-positive stromal cells in gastric carcinoma: correlation with invasion and metastasis
    Wen Bin Huang
    Department of Pathology, Clinical School of Medical College of Nanjing University Nanjing Jinling Hospital, 210002 Jiangsu Nanjing, People s Republic of China
    Jpn J Clin Oncol 35:245-50. 2005
    ..The aim of this study was to immunohistochemically investigate the rate of CD10 production in the stromal cells in our gastric carcinoma collection and clarify its correlation with invasion and metastasis...
  66. ncbi Tat peptides inhibit neprilysin
    Abigail Daily
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40538 0509, USA
    J Neurovirol 12:153-60. 2006
    ..However, Tat protein and Tat-derived peptides were recently also shown to inhibit neprilysin, the major amyloid beta peptide degrading enzyme in brain, in a cell aggregate system...
  67. ncbi Enkephalinase inhibitors: potential agents for the management of pain
    V Thanawala
    Department of Pharmacology, Bharati Vidyapeeth s College of Pharmacy, Sector 8, CBD Belapur, Navi Mumbai, Maharashtra, India
    Curr Drug Targets 9:887-94. 2008
    ..EIs possess the advantage that they lack the opioid side effects. This article reviews the mechanisms by which EIs act and elucidates the pathways involved...
  68. pmc The density of CD10 corresponds to commitment and progression in the human B lymphoid lineage
    Michiko Ichii
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 5:e12954. 2010
    ..The CD10 ectoenzyme is one such marker and has been used to define CLP, but we found substantial tissue specific variations in CD10 levels, and there was no information about how that corresponded to differentiation options...
  69. ncbi Histologic and immunohistologic findings and prognosis of 40 cases of gastric large B-cell lymphoma
    M Takeshita
    Department of Pathology, Clinical Laboratory, National Kyushu Medical Center Hospital, Fukuoka, Japan
    Am J Surg Pathol 24:1641-9. 2000
    ..Clinical staging and Bcl-6 expression were also good prognostic factors in patients with DLCL. Three groups of gastric DLCL each had unique histologic findings, immunohistologic characteristics, and prognosis...
  70. ncbi CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis
    K Ohshima
    First Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonan-ku, Fukuoka 814-01, Japan
    Histopathology 39:156-62. 2001
    ..Overall, our results suggest that CD10 expression may be useful, in combination with clinical parameters, for determining the prognosis of DLBCL...
  71. ncbi Neprilysin and amyloid beta peptide degradation
    Louis B Hersh
    Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY 40536, USA
    Curr Alzheimer Res 5:225-31. 2008
    b>Neprilysin is a zinc metalloendopeptidase with relatively broad substrate specificity. The enzyme is localized to the plasma membrane of cells where it can function to degrade extracellular peptides...
  72. pmc Neutral endopeptidase modulation of septic shock
    B Lu
    Ina Sue Perlmutter Laboratory, Children s Hospital, Boston, Massachusetts, USA
    J Exp Med 181:2271-5. 1995
    ..This unexpected finding indicates an important protective role for NEP in septic shock...
  73. pmc UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit
    C P Wayman
    Genitourinary Research Unit, Pfizer Global Research and Development, Sandwich, UK
    Br J Pharmacol 160:51-9. 2010
    ....
  74. pmc Neprilysin protects neurons against Abeta peptide toxicity
    Salim S El-Amouri
    Department of Molecular and Cellular Biochemistry, Medical University of South Carolina, Charleston, SC 29425, USA
    Brain Res 1152:191-200. 2007
    ..b>Neprilysin (NEP) appears to be the most potent Abeta peptide-degrading enzyme in the brain...
  75. pmc Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin
    Kaiwei Liang
    State Key Lab of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
    J Biol Chem 285:935-42. 2010
    ..we provide evidence that estrogen promotes Abeta degradation mainly through a principal Abeta degrading enzyme, neprilysin, in neuroblastoma SH-SY5Y cells...
  76. ncbi NEP-like endopeptidases and Alzheimer's disease [corrected]
    R A Marr
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Curr Alzheimer Res 7:223-9. 2010
    ..Of particular interest are endopeptidases that are sensitive to the neprilysin inhibitors thiorphan and phosphoramidon (i.e...
  77. ncbi Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes
    Lilia Fisk
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Mount Preston Street, Leeds, LS2 9JT, UK
    Neurochem Res 32:1741-8. 2007
    ..brain has an endogenous mechanism of Abeta removal via proteolytic degradation and the zinc metalloproteinase neprilysin (NEP) is a critical regulator of Abeta concentration. Down-regulation of NEP could predispose to AD...
  78. ncbi CD10 expression in stromal cells of ameloblastoma variants
    Giovanna Iezzi
    Research Fellow, Dental School, University of Chieti Pescara, Chieti Pescara, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:206-9. 2008
    ....
  79. doi Neprilysin 4, a novel endopeptidase from Drosophila melanogaster, displays distinct substrate specificities and exceptional solubility states
    Heiko Meyer
    Department of Zoology Developmental Biology, University of Osnabruck, Germany
    J Exp Biol 212:3673-83. 2009
    ..Here we report on the identification and first characterization of neprilysin 4 (NEP4) from Drosophila melanogaster...
  80. pmc Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice
    Brian Spencer
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    BMC Neurosci 9:109. 2008
    ..The endopeptidase, neprilysin, has been implicated as a major Abeta degrading enzyme in mice and humans...
  81. pmc Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease
    John B Rose
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurosci 29:1115-25. 2009
    The endopeptidase neprilysin (NEP) is a major amyloid-beta (Abeta) degrading enzyme and has been implicated in the pathogenesis of Alzheimer's disease...
  82. ncbi Lack of hepatocellular CD10 along bile canaliculi is physiologic in early childhood and persistent in Alagille syndrome
    Jane A Byrne
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, UK
    Lab Invest 87:1138-48. 2007
    ..Liver CD10 in childhood appears to undergo reduced synthesis or rapid degradation, which persists in AGS. Absence of CD10 expression thus may limit NEA as a marker of cholestasis in young patients and in AGS...
  83. ncbi Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide
    E Hama
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Med Hypotheses 65:498-500. 2005
    We recently demonstrated that amyloid beta peptide (Abeta) is catabolized primarily by a neutral endopeptidase, neprilysin, in the brain and that a neuropeptide, somatostatin (SST), regulates brain Abeta level via modulation of neprilysin ..
  84. doi Accumulation of insoluble amyloid-β in down's syndrome is associated with increased BACE-1 and neprilysin activities
    James Scott Miners
    Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Bristol, UK
    J Alzheimers Dis 23:101-8. 2011
    ..disease (AD)-related increases in the activities of β-secretase (BACE-1) and Aβ-degrading enzymes including neprilysin (NEP) and angiotensin-converting enzyme (ACE) in the frontal cortex...
  85. ncbi Comparison of multiparameter flow cytometry with cluster analysis and immunohistochemistry for the detection of CD10 in diffuse large B-Cell lymphomas
    Yin Xu
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    Mod Pathol 15:413-9. 2002
    ..Our results indicate 75% sensitivity and 100% specificity of CD10 expression by IHC compared with multiparameter FC with cluster analysis and a 6% technical failure rate...
  86. ncbi Clearance of Alzheimer's Abeta peptide: the many roads to perdition
    R E Tanzi
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
    Neuron 43:605-8. 2004
    ..This minireview will summarize pathways involved in the removal of cerebral Abeta, including enzymatic degradation and receptor-mediated efflux out of the brain...
  87. pmc Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease
    Matthew L Hemming
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Dis 26:273-81. 2007
    ..Furthermore, we find no change in plaque deposition or in peripheral Abeta levels. Data from these Alzheimer models suggest that captopril and similar ACE inhibitors do not cause Abeta accumulation in vivo...
  88. pmc Mechanisms of toxic smoke inhalation and burn injury: role of neutral endopeptidase and vascular leakage in mice
    Sam Jacob
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA
    Toxicol Mech Methods 19:191-6. 2009
    ..026) as compared to mice with SB injury alone. In conclusion the current study indicates that specific NEP inhibitor CGS 24592 exacerbates the SB-induced lung injury and inflammation in mice...
  89. ncbi Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cells
    F Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya 466 8550, Japan
    Placenta 25:176-83. 2004
    ..In conclusion, GnRH induces NEP expression by PKC delta and p38MAPK, and increased NEP expression may be involved in antiproliferative effect in BeWo cells...
  90. pmc Effects of combined neutral endopeptidase 24-11 and angiotensin-converting enzyme inhibition on femoral vascular conductance in streptozotocin-induced diabetic rats
    V Arbin
    Laboratoire de Pharmacologie, U266 INSERM, UMR 8600 CNRS, U F R des Sciences Pharmaceutiques et Biologiques, Paris, France
    Br J Pharmacol 130:1297-304. 2000
    ..These effects are linked to an increased activation of the kinin-NO pathway. BK could lead to NO production by BK B2 receptor activation and another pathway in which kininase I may be involved...
  91. ncbi Substance P and neutral endopeptidase in development of acute respiratory distress syndrome following fire smoke inhalation
    Simon S Wong
    Department of Pediatrics Critical Care Medicine, The University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Am J Physiol Lung Cell Mol Physiol 287:L859-66. 2004
    ....
  92. ncbi Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit
    Raphael Poirier
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, Zurich 8008, Switzerland
    Neurobiol Dis 24:475-83. 2006
    ..Lowering brain Abeta levels, therefore, is a therapeutic strategy for the treatment of AD. Neuronal neprilysin upregulation led to increased degradation of Abeta, reduced the formation of Abeta-plaques and the associated ..
  93. ncbi Treatment of streptozotocin-induced diabetic rats with AVE7688, a vasopeptidase inhibitor: effect on vascular and neural disease
    Eric P Davidson
    Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA 52246, USA
    Diabetes 56:355-62. 2007
    ..These studies suggest that vasopeptidase inhibitors may be an effective approach for the treatment of diabetic vascular and neural dysfunction...
  94. ncbi Roles of neutral endopeptidase in airways
    D B Borson
    Department of Physiology, University of California, San Francisco 94143 0911
    Am J Physiol 260:L212-25. 1991
    ....
  95. ncbi Bradykinin and matrix metalloproteinases are involved the structural alterations of rat small resistance arteries with inhibition of ACE and NEP
    Damiano Rizzoni
    Department of Medical and Surgical Sciences, University of Brescia, DMCS Clinica Medica 4, University of Padua, Italy
    J Hypertens 22:759-66. 2004
    ....
  96. ncbi Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies
    Randal A Skidgel
    Department of Pharmacology, University of Illinois College of Medicine, Pharmacology MC 868, 835 S Wolcott Avenue, Chicago, IL 60612 7344, USA
    Peptides 25:521-5. 2004
    ..extended to the hydrolysis of the neuropeptide, neurotensin and to compare hydrolysis of the same peptides by neprilysin (neutral endopeptidase 24.11, CD10, NEP)...
  97. pmc Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways
    Eva Sanz
    Departamento de Medicina, Universidad de Alcala, Alcalá de Henares 28805, Spain
    Proc Natl Acad Sci U S A 107:5925-30. 2010
    ..Here, we show a similar divergence in human B-cell development pathways between the Pax5(+)TdT(-) pre/pro-B differentiation pathway that gives rise to infant B-lineage leukemias and the early-B pathway...
  98. ncbi CD10 expression in diffuse large B-cell lymphomas does not influence survival
    Bettina Fabiani
    Departement de Pathologie, Hopital Saint Antoine, AP HP, Paris, France
    Virchows Arch 445:545-51. 2004
    ..44 and P=0.34 respectively). Therefore, it appears that CD10 expression does not influence survival or event-free survival in DLBCL...
  99. ncbi Induction of neutral endopeptidase (NEP) activity of SK-N-SH cells by natural compounds from green tea
    Shereen Ayoub
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Str 2 4, 14195 Berlin, Germany
    J Pharm Pharmacol 58:495-501. 2006
    ..It is suggested that the enhancement of cellular neutral endopeptidase activity by green tea extract and its natural products might be correlated with an elevated level of intracellular cyclic adenosine monophosphate...
  100. doi Hyposialylation of neprilysin possibly affects its expression and enzymatic activity in hereditary inclusion-body myopathy muscle
    Aldobrando Broccolini
    Department of Neuroscience, Catholic University, School of Medicine, Rome, Italy
    J Neurochem 105:971-81. 2008
    ..h-IBM muscle shows the abnormal accumulation of proteins including amyloid-beta (Abeta). Neprilysin (NEP), a metallopeptidase that cleaves Abeta, is characterized by the presence of several N-glycosylation sites, ..
  101. ncbi Involvement of neutral endopeptidase in neoplastic progression
    Makoto Sumitomo
    Department of Urology, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    Biochim Biophys Acta 1751:52-9. 2005
    ..We review the mechanisms of NEP's tumor suppressive action and how NEP loss contributes to tumor progression...

Research Grants76

  1. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010
    ....
  2. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS contact KIRKWOOD; Fiscal Year: 2010
    ....
  3. NEUROPEPTIDE DEGRADATION IN THE SMALL INTESTINE
    Nigel Bunnett; Fiscal Year: 1993
    ..Knowledge of interaction between NEP, SPR and SP will provide basic information about the nature of peptidergic neurotransmission in the normal and inflamed intestine...
  4. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
    ..Together, the results of these experiments will provide new insights into peptide signaling, generate novel information about mechanisms of intestinal inflammation, and suggest new strategies for therapy. ..
  5. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2010
    ..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of angiotensin converting enzyme and/or vasopeptidase inhibitor treatment in human diabetic neuropathy. ..
  6. Prevention of Diabetic Neuropathy with ACE Inhibitors
    Mark Yorek; Fiscal Year: 2009
    ..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of angiotensin converting enzyme and/or vasopeptidase inhibitor treatment in human diabetic neuropathy. ..
  7. INTRARENAL REGULATION OF SODIUM EXCRETION
    John Burnett; Fiscal Year: 2004
    ..Aim 4: Establish that dietary sodium excess accelerates the development of cardiac remodeling and overt CHF in part via up-regulation of NEP. ..
  8. NEURAL REGULATION OF PANCREATIC FUNCTION
    Kimberly Kirkwood; Fiscal Year: 2002
    ..Using neurokinin receptor antagonists, peptidase inhibitors, and knockout mice, we will delineate the neurogenic mechanisms that regulate inflammation in acute pancreatitis. ..
  9. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 1999
    ....
  10. INTRARENAL REGULATION OF SODIUM EXCRETION
    John Burnett; Fiscal Year: 2000
    ....
  11. TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPE
    Marcia N Gordon; Fiscal Year: 2010
    ..b>Neprilysin is a major amyloid degrading protease, and a prime candidate for use in anti-amyloid gene therapy...
  12. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2010
    ..of some of these proteases in vivo have resulted in increased steady-state levels of brain A? in mice, including neprilysin (NEP), insulin-degrading enzyme (IDE), endothelin-converting enzyme (ECE)...
  13. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2009
    ..of some of these proteases in vivo have resulted in increased steady-state levels of brain A? in mice, including neprilysin (NEP), insulin-degrading enzyme (IDE), endothelin-converting enzyme (ECE)...
  14. Prevention of Diabetic Neuropathy with ACE Inhibitors
    Mark Yorek; Fiscal Year: 2007
    ..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of ACE inhibitor treatment in human DN. ..
  15. A screen for small molecule inhibitors of soluble Abeta oligomer assembly
    Harry LeVine; Fiscal Year: 2007
    ..with compound, will be screened with trypsin, and if positive, digested with insulin-degrading enzyme and neprilysin, proteases believed to degrade Abeta peptides in vivo...
  16. DIABETIC NEUROPATHY: IMPLICATIONS FOR WOUND REPAIR
    Nicole Gibran; Fiscal Year: 2002
    ..Using an excisional would model in hyperglycemia db/db mice, we will replace substance P, replace NGF or inhibit neutral endopeptidase activity to evaluate the roles of neuropeptides and NGF in wound repair. ..
  17. The Role of Cathepsin B and Cystatin C in Alzheimer's Disease
    Li Gan; Fiscal Year: 2010
    ..However, unlike some other Abeta degradation enzymes, such as neprilysin (NEP, an endopeptidase with optimal activity at a neutral pH), CatB truncates Abeta at the C-terminus with ..
  18. GENES AND FIBRINOLYTIC CAPACITY OF HUMAN ENDOTHELIUM
    Nancy Brown; Fiscal Year: 2006
    ..It is expected that these pharmacogenetic studies will yield critical new information and strategies for enhancing the favorable effect of the kallikrein-kinin system on fibrinolysis and the risk of thrombotic cardiovascular events. ..
  19. LXR and PPARgamma mediated Abeta clearance mechanisms
    Gary Landreth; Fiscal Year: 2007
    ..that lipidated forms of ApoE facilitate the intracellular degradation of A¿ peptides by microglia through neprilysin- dependent proteolysis...
  20. LXR and PPARgamma mediated Abeta clearance mechanisms
    Gary Landreth; Fiscal Year: 2009
    ..We show that lipidated forms of ApoE facilitate the intracellular degradation of A peptides by microglia through neprilysin- dependent proteolysis...
  21. LXR and PPARgamma mediated Abeta clearance mechanisms
    Gary Landreth; Fiscal Year: 2009
    ..We show that lipidated forms of ApoE facilitate the intracellular degradation of A peptides by microglia through neprilysin- dependent proteolysis...