carcinoembryonic antigen

Summary

Summary: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.

Top Publications

  1. ncbi ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer
    Gershon Y Locker
    American Society of Clinical Oncology Tumor Markers Expert Panel, Alexandria, VA 22314, USA
    J Clin Oncol 24:5313-27. 2006
  2. ncbi CEACAMs: their role in physiology and pathophysiology
    Katharina Kuespert
    Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universitat Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany
    Curr Opin Cell Biol 18:565-71. 2006
  3. ncbi The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues
    S Hammarstrom
    Department of Immunology, Umea University, Umea, SE 90185, Sweden
    Semin Cancer Biol 9:67-81. 1999
  4. ncbi Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts
    Sevdenur Cizginer
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02116, USA
    Pancreas 40:1024-8. 2011
  5. ncbi Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer
    Sharmeela Kaushal
    Department of Surgery, University of California San Diego, Moores Cancer Center, 3855 Health Sciences Drive 0987, La Jolla, CA 92093 0987, USA
    J Gastrointest Surg 12:1938-50. 2008
  6. ncbi Redefined nomenclature for members of the carcinoembryonic antigen family
    N Beauchemin
    McGill Cancer Centre, McGill University, Montreal, Qué Canada H3G 1Y6
    Exp Cell Res 252:243-9. 1999
  7. pmc Phase I trial of intraperitoneal administration of an oncolytic measles virus strain engineered to express carcinoembryonic antigen for recurrent ovarian cancer
    Evanthia Galanis
    Division of Medical Oncology, Department of Molecular Medicine, Mayo Clinic, Gonda 10 141, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Res 70:875-82. 2010
  8. pmc Carcinoembryonic antigen interacts with TGF-{beta} receptor and inhibits TGF-{beta} signaling in colorectal cancers
    Ying Li
    Department of Gastroenterology, Hepatology and Nutrition, M D Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    Cancer Res 70:8159-68. 2010
  9. pmc T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
    Maria R Parkhurst
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 19:620-6. 2011
  10. ncbi Toward standardized high-throughput serum diagnostics: multiplex-protein array identifies IL-8 and VEGF as serum markers for colon cancer
    Stefanie Bünger
    Laboratory for Surgical Research, Department of Surgery, University of Lubeck, Germany
    J Biomol Screen 16:1018-26. 2011

Detail Information

Publications360 found, 100 shown here

  1. ncbi ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer
    Gershon Y Locker
    American Society of Clinical Oncology Tumor Markers Expert Panel, Alexandria, VA 22314, USA
    J Clin Oncol 24:5313-27. 2006
    ..To update the recommendations for the use of tumor marker tests in the prevention, screening, treatment, and surveillance of gastrointestinal cancers...
  2. ncbi CEACAMs: their role in physiology and pathophysiology
    Katharina Kuespert
    Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universitat Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany
    Curr Opin Cell Biol 18:565-71. 2006
    b>Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins...
  3. ncbi The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues
    S Hammarstrom
    Department of Immunology, Umea University, Umea, SE 90185, Sweden
    Semin Cancer Biol 9:67-81. 1999
    ..A modified ITAM/ITIM motif is identified in the cytoplasmatic domain of BGP. A role of CEA in innate immunity is envisioned...
  4. ncbi Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts
    Sevdenur Cizginer
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02116, USA
    Pancreas 40:1024-8. 2011
    ..The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts...
  5. ncbi Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer
    Sharmeela Kaushal
    Department of Surgery, University of California San Diego, Moores Cancer Center, 3855 Health Sciences Drive 0987, La Jolla, CA 92093 0987, USA
    J Gastrointest Surg 12:1938-50. 2008
    ..In both of these cancers, complete detection of primary and metastatic lesions at the time of surgery is critical to optimal surgical resection and appropriate patient treatment...
  6. ncbi Redefined nomenclature for members of the carcinoembryonic antigen family
    N Beauchemin
    McGill Cancer Centre, McGill University, Montreal, Qué Canada H3G 1Y6
    Exp Cell Res 252:243-9. 1999
  7. pmc Phase I trial of intraperitoneal administration of an oncolytic measles virus strain engineered to express carcinoembryonic antigen for recurrent ovarian cancer
    Evanthia Galanis
    Division of Medical Oncology, Department of Molecular Medicine, Mayo Clinic, Gonda 10 141, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Res 70:875-82. 2010
    ..We engineered MV to express the marker peptide carcinoembryonic antigen (MV-CEA virus) to also permit real-time monitoring of viral gene expression in tumors in the clinical ..
  8. pmc Carcinoembryonic antigen interacts with TGF-{beta} receptor and inhibits TGF-{beta} signaling in colorectal cancers
    Ying Li
    Department of Gastroenterology, Hepatology and Nutrition, M D Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    Cancer Res 70:8159-68. 2010
    As a tumor marker for colorectal cancers, carcinoembryonic antigen (CEA) enhances the metastatic potential of cancer cells. CEA functions as an intercellular adhesion molecule and is upregulated in a wide variety of human cancers...
  9. pmc T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
    Maria R Parkhurst
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 19:620-6. 2011
    Autologous T lymphocytes genetically engineered to express a murine T cell receptor (TCR) against human carcinoembryonic antigen (CEA) were administered to three patients with metastatic colorectal cancer refractory to standard treatments...
  10. ncbi Toward standardized high-throughput serum diagnostics: multiplex-protein array identifies IL-8 and VEGF as serum markers for colon cancer
    Stefanie Bünger
    Laboratory for Surgical Research, Department of Surgery, University of Lubeck, Germany
    J Biomol Screen 16:1018-26. 2011
    ..protein array, the authors explore a panel of cytokines simultaneously and compared its performance to carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9)...
  11. ncbi Decline in serum carcinoembryonic antigen and cytokeratin 19 fragment during chemotherapy predicts objective response and survival in patients with advanced nonsmall cell lung cancer
    Andrea Ardizzoni
    Division of Medical Oncology, University Hospital of Parma, Parma, Italy
    Cancer 107:2842-9. 2006
    The authors assessed the predictive and prognostic role of decline in the serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA 21-1) during chemotherapy in patients with advanced nonsmall cell lung cancer (..
  12. ncbi Prognostic value of carcinoembryonic antigen and CYFRA21-1 in patients with pathological stage I non-small cell lung cancer
    Katsunari Matsuoka
    Department of Thoracic Surgery, Japanese Red Cross Society Wakayama Medical Center, Japan
    Eur J Cardiothorac Surg 32:435-9. 2007
    The aim of this retrospective study was to assess the prognostic value of serum tumor markers (carcinoembryonic antigen (CEA) and CYFRA21-1) in patients with pathologic (p-) stage I non-small cell lung cancer (NSCLC) undergoing complete ..
  13. pmc Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Cancer Res 65:622-31. 2005
    ..the half-life of engineered antibodies, we have mutated the Fc-FcRn binding site of chimeric anti-carcinoembryonic antigen (CEA) antibodies produced in a single-chain Fv-Fc format. The anti-CEA T84...
  14. ncbi Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful?
    M J Duffy
    Department of Nuclear Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Clin Chem 47:624-30. 2001
    b>Carcinoembryonic antigen (CEA) is one of the most widely used tumor markers worldwide. Its main application is mostly in gastrointestinal cancers, especially in colorectal malignancy...
  15. pmc Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas
    S Schölzel
    Institutes of Molecular Medicine, University of Freiburg, Department of Surgery, University Hospital, Freiburg, Germany
    Am J Pathol 156:595-605. 2000
    Four members of the carcinoembryonic antigen (CEA) family, CEA, CEACAM1 (BGP), CEACAM6 (NCA-50/90), and CEACAM7 (CGM2), are coexpressed in normal colorectal epithelia but are deregulated in colorectal cancers, where they could play a role ..
  16. ncbi Progression of medullary thyroid carcinoma: assessment with calcitonin and carcinoembryonic antigen doubling times
    Anne Laure Giraudet
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy and University Paris Sud, 94805 Villejuif Cedex, France
    Eur J Endocrinol 158:239-46. 2008
    The progression of medullary thyroid cancer is difficult to assess with imaging modalities; we studied the interest of calcitonin and carcinoembryonic antigen (CEA) doubling times and of Ki-67 labeling and mitotic index (MI).
  17. ncbi Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer
    Mitchell J Goldstein
    Division of Neoplastic Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Invest 23:338-51. 2005
    ..Immunotherapy based on CEA is a rapidly advancing area of clinical research demonstrating antibody and T-cell responses...
  18. pmc Pretargeted immuno-positron emission tomography imaging of carcinoembryonic antigen-expressing tumors with a bispecific antibody and a 68Ga- and 18F-labeled hapten peptide in mice with human tumor xenografts
    Rafke Schoffelen
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Cancer Ther 9:1019-27. 2010
    ..Mice were implanted with carcinoembryonic antigen (CEA; CEACAM5)-expressing LS174T human colonic tumors and a CEA-negative tumor, or an inflammation was ..
  19. ncbi CEA adhesion molecules: multifunctional proteins with signal-regulatory properties
    B Obrink
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Curr Opin Cell Biol 9:616-26. 1997
    The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities...
  20. ncbi Use of a vaccine strain of measles virus genetically engineered to produce carcinoembryonic antigen as a novel therapeutic agent against glioblastoma multiforme
    Loi K Phuong
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 63:2462-9. 2003
    ..of measles virus (MV), derived from the Edmonston vaccine lineage, genetically engineered to produce carcinoembryonic antigen (CEA). CEA production as the virus replicates can serve as a marker of viral gene expression...
  21. ncbi Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site
    S M Watt
    Stem Cell Laboratory, National Blood Service, Nuffield Department of Clinical and Laboratory Sciences, and the MRC Molecular Haematology Unit, Institute of Molecular Medicine, Oxford, United Kingdom
    Blood 98:1469-79. 2001
    ....
  22. pmc Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells
    J Guignot
    Institut National de la Sante et de la Recherche Medicale, Unité 510, Faculte de Pharmacie Paris XI, F 92296 Chatenay Malabry, France
    Infect Immun 68:3554-63. 2000
    ..We show that the brush border-associated glycosylphosphatidylinositol (GPI)-anchored protein CD66e (carcinoembryonic antigen) is recruited by the Afa/Dr DAEC strains C1845 and IH11128...
  23. ncbi Can preoperative CA19-9 and CEA levels predict the resectability of patients with pancreatic adenocarcinoma?
    Young Choon Kim
    Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, Korea
    J Gastroenterol Hepatol 24:1869-75. 2009
    We aimed to explore the predictive ability of preoperative carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) levels for assessing tumor resectability (R0 resection) in patients with pancreatic adenocarcinoma.
  24. ncbi Detection of cytokeratin 19, human mammaglobin, and carcinoembryonic antigen-positive circulating tumor cells by three-marker reverse transcription-PCR assay and its relation to clinical outcome in early breast cancer
    Yan Chen
    Yunnan Tumor Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Tumor Hospital, Kunming, China
    Int J Biol Markers 25:59-68. 2010
    ..To investigate the diagnostic, predictive, and prognostic value of the detection of circulating tumor cells (CTCs) using a three-marker (CK19, hMAM and CEA) RT-PCR assay in patients with early breast cancer...
  25. ncbi The prognostic significance of preoperative serum CA 19-9 in patients with resectable gastric carcinoma: comparison with CEA
    N Duraker
    Third Department of Surgery, SSK Okmeydani Training Hospital, Istanbul, Turkey
    J Surg Oncol 76:266-71. 2001
    In this study, the prognostic value of pre-operative serum levels of tumor markers CA 19-9 and carcinoembryonic antigen (CEA) in gastric carcinoma which has been a controversial matter was investigated.
  26. pmc Second-generation anti-carcinoembryonic antigen designer T cells resist activation-induced cell death, proliferate on tumor contact, secrete cytokines, and exhibit superior antitumor activity in vivo: a preclinical evaluation
    Peter C R Emtage
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institute of Human Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 14:8112-22. 2008
    ..This report describes the development and preclinical qualification tests of second-generation anti-carcinoembryonic (CEA) designer T cells for use in human trials...
  27. ncbi Novel mouse model for carcinoembryonic antigen-based therapy
    Carlos H F Chan
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Ther 9:775-85. 2004
    ..immunotherapy and gene therapy, are specifically targeted to tumor-associated molecules, among which carcinoembryonic antigen (CEA) represents a popular example...
  28. pmc Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae
    Helen Sarantis
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Infect Immun 80:345-58. 2012
    ..Neisseria interacts with neutrophils through ligation of human carcinoembryonic antigen related-cellular adhesion molecules (CEACAMs) by their surface-expressed Opa proteins, resulting in ..
  29. ncbi Radioimmunotherapy and colorectal cancer
    M J Koppe
    Department of Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Surg 92:264-76. 2005
    ..In the past decade, a dozen Mabs have been investigated clinically for their potential usefulness in RIT of colorectal cancer...
  30. ncbi Angiogenic properties of the carcinoembryonic antigen-related cell adhesion molecule 1
    C Wagener
    Department of Clinical Chemistry, Institute of Anatomy, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, D 20251, Germany
    Exp Cell Res 261:19-24. 2000
    The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a member of the immunoglobulin superfamily, is expressed in microvessels of proliferating tissues such as endometrium, in tissues after wounding, and in solid human ..
  31. pmc Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor
    Hao Pan
    City of Hope Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 1450 E Duarte Road, Duarte, CA 91010, USA
    Immunity 33:620-31. 2010
    Although carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) is an activation marker for neutrophils and delays neutrophil apoptosis, the role of CEACAM1 in granulopoiesis and neutrophil-dependent host immune responses has ..
  32. ncbi Preoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels for the evaluation of curability and resectability in patients with pancreatic adenocarcinoma
    Shuichi Fujioka
    Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    J Hepatobiliary Pancreat Surg 14:539-44. 2007
    Although carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) are the most studied serum tumor markers that have been evaluated for diagnosis and prognosis in patients with pancreatic cancer, little is known of the value ..
  33. pmc Investigations on the usefulness of CEACAMs as potential imaging targets for molecular imaging purposes
    Markus Heine
    Institute of Anatomy and Experimental Morphology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e28030. 2011
    Members of the carcinoembryonic antigen cell adhesion molecules (CEACAMs) family are the prototype of tumour markers. Classically they are used as serum markers, however, CEACAMs could serve as targets for molecular imaging as well...
  34. pmc Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers
    Rosalyn D Blumenthal
    Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ 07109, USA
    BMC Cancer 7:2. 2007
    ..breast, pancreatic, colonic and non-small-cell lung carcinoma lines express CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen, CEA), and antibodies to both can affect tumor cell growth in vitro and in vivo...
  35. pmc Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen
    Cinzia Remondo
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Vaccine 27:987-94. 2009
    Tumor-associated antigens are weakly immunogenic. Human carcinoembryonic antigen (CEA) is overexpressed on a wide range of human carcinomas and represents an attractive target for cancer immunotherapy...
  36. ncbi Elevated preoperative carcinoembryonic antigen (CEA) and Ki67 is predictor of decreased survival in IIA stage colon cancer
    Yifan Peng
    Department of Colorectal Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Cancer Hospital and Institute, Beijing Cancer Hospital, Beijing, People s Republic of China
    World J Surg 37:208-13. 2013
    ..The present study was designed to investigate the prognostic factors of stage IIA (pT3N0M0) colon cancer...
  37. pmc A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus
    D S Chen
    Howard Hughes Medical Institute, School of Medicine, University of Southern California, Los Angeles 90033 1054, USA
    Proc Natl Acad Sci U S A 92:12095-9. 1995
    ..cDNA library, we have identified a member of the pregnancy-specific glycoprotein (PSG) subgroup of the carcinoembryonic antigen gene family...
  38. ncbi Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imaging
    Katy M Venisnik
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 9:267-77. 2007
    The bioluminescent protein Gaussia luciferase (GLuc) was fused to an anti-carcinoembryonic antigen (CEA) antibody fragment, the diabody, for in vivo optical tumor imaging...
  39. pmc Serum CYFRA 21-1 (cytokeratin-19 fragments) is a useful tumour marker for detecting disease relapse and assessing treatment efficacy in breast cancer
    B Nakata
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Br J Cancer 91:873-8. 2004
    ..The sera from 173 patients with primary breast cancer or recurrent disease were measured for CYFRA 21-1, carcinoembryonic antigen (CEA), and carbohydrate antigen 15-3 (CA 15-3) levels...
  40. ncbi The role of carcinoembriogenic antigen in predicting response and survival to neoadjuvant chemoradiotherapy for distal rectal cancer
    Rodrigo O Perez
    Colorectal Surgery Division, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Dis Colon Rectum 52:1137-43. 2009
    ..Therefore, we hypothesized that a decrease in CEA after neoadjuvant chemoradiotherapy could reflect tumor response to chemoradiotherapy, affecting final disease stage and ultimately survival...
  41. pmc A pilot study of MUC-1/CEA/TRICOM poxviral-based vaccine in patients with metastatic breast and ovarian cancer
    Mahsa Mohebtash
    Medical Oncology Branch and Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 17:7164-73. 2011
    ..This study was conducted to obtain preliminary evidence of clinical response in metastatic breast and ovarian cancer patients...
  42. ncbi Comparative toxicity and efficacy of combined radioimmunotherapy and antiangiogenic therapy in carcinoembryonic antigen-expressing medullary thyroid cancer xenograft
    Françoise Kraeber-Bodéré
    INSERM UMR 892 Cancer Research Center, Universite de Nantes, Nantes, France
    J Nucl Med 51:624-31. 2010
    A significant antitumor effect was previously observed with radioimmunotherapy using anti-carcinoembryonic antigen (131)I-F6 monoclonal antibody in medullary thyroid cancer-bearing nude mice...
  43. ncbi Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgery
    Ji Won Park
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Republic of Korea
    Int J Radiat Oncol Biol Phys 74:810-7. 2009
    To evaluate the role of serum carcinoembryonic antigen (CEA) as a predictor of response to preoperative chemoradiotherapy (CRT) and prognostic factor for rectal cancer.
  44. ncbi Clinical significance of CEA and CA19-9 in postoperative follow-up of colorectal cancer
    Tomomi Yakabe
    Faculty of Medicine, Department of Surgery, Saga University, Saga, Japan
    Ann Surg Oncol 17:2349-56. 2010
    ..We evaluated the efficiency of CEA and CA19-9 as tools for diagnosing recurrence in the postoperative surveillance of colorectal cancer...
  45. ncbi Pretargeted 177Lu radioimmunotherapy of carcinoembryonic antigen-expressing human colonic tumors in mice
    Rafke Schoffelen
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 51:1780-7. 2010
    ..In this study, the optimization, therapeutic efficacy, and toxicity of PRIT of colon cancer with a (177)Lu-labeled peptide was determined in mice with carcinoembryonic antigen (CEA)-expressing human tumors.
  46. ncbi Prognostic value of combination of Cyfra 21-1, CEA and NSE in patients with advanced non-small cell lung cancer
    Fabrice Barlesi
    Faculty of Medicine, Universite de la Mediterranee, Assistance Publique Hopitaux de Marseille, Service d Oncologie Thoracique, Marseille, Cedex 09, France
    Respir Med 98:357-62. 2004
    ..To assess the value of Cyfra 21-1, carcino-embryonic antigen (CEA) and neuron-specific enolase (NSE) combined, all three together as prognostic factors in advanced stage non-small cell lung cancer (NSCLC) patients...
  47. pmc Diagnostic performance of cyst fluid carcinoembryonic antigen and amylase in histologically confirmed pancreatic cysts
    Walter Gwang Up Park
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Pancreas 40:42-5. 2011
    ....
  48. pmc Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    Michael A Morse
    Department ofMedicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 112:610-8. 2008
    ..We then attempted to enhance antitumor immune responses in patients with carcinoembryonic antigen (CEA)-expressing malignancies by Treg-cell depletion...
  49. ncbi CEACAM1 regulates insulin clearance in liver
    Matthew N Poy
    Department of Pharmacology, 3035 Arlington Avenue, HSci Building Room 270, Toledo, Ohio 43614, USA
    Nat Genet 30:270-6. 2002
    ..These findings suggest a mechanism through which insulin signaling regulates insulin sensitivity by modulating hepatic insulin clearance...
  50. ncbi Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family
    Roland Zebhauser
    Tumor Immunology Laboratory, Department of Urology, University Clinic Grosshadern, Ludwig Maximilians University Munchen, Marchioninistrasse 23, D 81377 Munich, Germany
    Genomics 86:566-80. 2005
    The carcinoembryonic antigen (CEA) family comprises a still actively evolving populous group of proteins that are involved in controlling tissue homeostasis, immune responses, and host/pathogen interactions...
  51. ncbi Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma
    Kimberly Blackwell
    Division of Medical Oncology, Duke University Comprehensive Cancer Center, Durham, NC 27710, USA
    Cancer 101:77-82. 2004
    ....
  52. ncbi Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria
    Manish Sadarangani
    Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford, UK
    FEMS Microbiol Rev 35:498-514. 2011
    ..Most immune interactions are mediated via binding to members of the carcinoembryonic antigen cell adhesion molecule (CEACAM) family...
  53. ncbi CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils
    K M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
    J Leukoc Biol 60:106-17. 1996
    Four members of the carcinoembryonic antigen family, CD66a, CD66b, CD66c, and CD66d, are expressed on human neutrophils...
  54. pmc Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens
    Tim Schmitter
    Zentrum für Infektionsforschung, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Exp Med 199:35-46. 2004
    b>Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are used by several human pathogens to anchor themselves to or invade host cells...
  55. ncbi Carcinoembryonic antigen (CEA) as tumor marker in lung cancer
    M Grunnet
    Department of Oncology, National University Hospital, Copenhagen, Denmark
    Lung Cancer 76:138-43. 2012
    ..Future studies may benefit from evaluating more than one marker at a time, which may possibly create a more precise index for prognosis and recurrence in lung cancer, than is possible by the use of single biomarkers...
  56. ncbi Plasma urokinase receptor levels in patients with colorectal cancer: relationship to prognosis
    R W Stephens
    The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    J Natl Cancer Inst 91:869-74. 1999
    ..This retrospective study was undertaken to test the relationship between preoperative plasma levels of soluble uPAR (suPAR) and survival in patients with colorectal cancer...
  57. ncbi Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma
    Boris Blechacz
    Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA
    Hepatology 44:1465-77. 2006
    ..We evaluated recombinant MV-Edm expressing carcinoembryonic antigen (CEA) or the human sodium iodide symporter (hNIS) for oncolytic potential in hepatocellular carcinoma (..
  58. pmc Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis
    Oscar Arrieta
    Department of Medical Oncology, Instituto Nacional de Cancerologia, Mexico City, Mexico
    BMC Cancer 9:119. 2009
    ....
  59. ncbi Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC)
    Cedric N Berger
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 510, Faculte de Pharmacie Paris XI, F 92296 Chatenay Malabry, France
    Mol Microbiol 52:963-83. 2004
    ..recognize as receptors the GPI-anchored proteins CD55 (decay-accelerating factor, DAF) and CD66e (carcinoembryonic antigen, CEA)...
  60. ncbi Regulation of insulin action by CEACAM1
    Sonia M Najjar
    Department Pharmacology and Therapeutics, Medical College of Ohio, 3035 Arlington Ave, HSci Building, Room 270, Toledo, OH 43614, USA
    Trends Endocrinol Metab 13:240-5. 2002
    ..Earlier studies in transfected cells suggested that the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a substrate of the insulin receptor in liver, upregulates ..
  61. ncbi Isolated paraaortic lymph node recurrence after definitive irradiation for cervical carcinoma
    H H Chou
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Int J Radiat Oncol Biol Phys 51:442-8. 2001
    ..To evaluate the clinical features of isolated paraaortic lymph node (PALN) recurrence after definitive radiotherapy, and analyze the prognostic factors and effect of salvage treatment...
  62. ncbi Serum tumor markers CEA, CYFRA21-1, and CA-125 are associated with worse prognosis in advanced non-small-cell lung cancer (NSCLC)
    Susana Cedres
    Medical Oncology Department, Vall d Hebron University Hospital, Barcelona, Spain
    Clin Lung Cancer 12:172-9. 2011
    ..Serum tumor markers are considered a negative prognostic factor in early-stages NSCLC but its role in advanced disease is controversial. The aim of this study is to analyze the prognostic value of tumor markers in advanced NSCLC...
  63. ncbi Protein expression of carcinoembryonic antigen cell adhesion molecules in benign and malignant melanocytic skin lesions
    Thilo Gambichler
    Dept of Dermatology and Allergology, Ruhr University Bochum, Germany
    Am J Clin Pathol 131:782-7. 2009
    ..nevi (BN), dysplastic nevi (DN), and primary superficial spreading melanoma (SSM) was performed for carcinoembryonic antigen (CEA) and CEA cell adhesion molecule-1 (CEACAM1) using monoclonal antibodies...
  64. pmc Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation
    Christian Ilantzis
    McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Neoplasia 4:151-63. 2002
    Human carcinoembryonic antigen (CEA) and the CEA family member CEACAM6 (formerly nonspecific cross-reacting antigen [NCA]) function in vitro, at least, as homotypic intercellular adhesion molecules and, in model systems, can block the ..
  65. ncbi Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter
    Kosei Hasegawa
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 12:1868-75. 2006
    ..being tested in patients with ovarian cancer and whose propagation can be monitored by measuring blood carcinoembryonic antigen (CEA) levels...
  66. ncbi CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor
    S Ergun
    Department of Anatomy, University Hospital Eppendorf, Hamburg, Germany
    Mol Cell 5:311-20. 2000
    ..Since CEACAM1 is expressed in tumor microvessels but not in large blood vessels, CEACAM1 may be a target for the inhibition of tumor angiogenesis...
  67. pmc Species-specific evolution of immune receptor tyrosine based activation motif-containing CEACAM1-related immune receptors in the dog
    Robert Kammerer
    Tumor Immunology Laboratory, LIFE Center, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr, 23, 81377 Munich, Germany
    BMC Evol Biol 7:196. 2007
    ..The CEA (carcinoembryonic antigen) gene family codes for such proteins and indeed shows tremendous species-specific variation between human ..
  68. ncbi Update of carcinoembryonic antigen radioimmunotherapy with (131)I-labetuzumab after salvage resection of colorectal liver metastases: comparison of outcome to a contemporaneous control group
    Torsten Liersch
    Department of General Surgery, University of Gottingen, Gottingen, Germany
    Ann Surg Oncol 14:2577-90. 2007
    ..Resection of LM from colorectal cancer is the standard of care in this setting, yet two thirds will eventually relapse, and adjuvant systemic chemotherapy has failed to improve survival...
  69. ncbi Clinical parameters predicting pathologic tumor response after preoperative chemoradiotherapy for rectal cancer
    Sang Min Yoon
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    Int J Radiat Oncol Biol Phys 69:1167-72. 2007
    ..To identify pretreatment clinical parameters that could predict pathologic tumor response to preoperative chemoradiotherapy (CRT) for rectal cancer...
  70. ncbi Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Department of Radioimmunotherapy, Duarte, CA, USA
    Cancer Res 67:718-26. 2007
    ..We studied the behavior of three anti-carcinoembryonic antigen (CEA) single-chain Fv-Fc (scFv-Fc) variants (I253A, H310A, and H310A/H435Q; Kabat numbering system) that ..
  71. ncbi Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma
    Jacques Barbet
    Département de Recherche en Cancérologie, Institut National de la Sante et de la Recherche Medicale, Unite 601, Institut de Biologie, 9 quai Moncousu, 44093 Nantes Cedex 1, France
    J Clin Endocrinol Metab 90:6077-84. 2005
    ..After unsuccessful surgery, medullary thyroid carcinoma (MTC) may be fatal or remain stable for decades, and precise survival predictors are needed...
  72. pmc Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways
    Oliver Billker
    Max Planck Institut für Infektionsbiologie, Abteilung Molekulare Biologie, Schumannstrasse 21 22, D 10117 Berlin, Germany
    EMBO J 21:560-71. 2002
    Opa adhesins of pathogenic Neisseria species target four members of the human carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) family...
  73. pmc Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors
    Shannon E McCaw
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Infect Immun 72:2742-52. 2004
    ..Neisseria gonorrhoeae colony opacity-associated (Opa) protein variants can bind up to four different carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) receptors...
  74. ncbi SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms
    Takashi Nagaishi
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunity 25:769-81. 2006
    ..Thus, CEACAM1 overexpression or deletion in T cells resulted in T cell inhibition or activation, respectively, revealing a role for CEACAM1 as a class of inhibitory receptors potentially amenable to therapeutic manipulation...
  75. ncbi Prognostic significance of response to preoperative radiotherapy, lymph node metastasis, and CEA level in patients undergoing total mesorectal excision of rectal cancer
    Soichiro Ishihara
    Department of Surgery, Teikyo University, 2 11 1, Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Int J Colorectal Dis 25:1417-25. 2010
    ..of the response of primary rectal lesions to preoperative radiotherapy, pathological nodal status, and carcinoembryonic antigen (CEA) levels before and after radiotherapy in rectal cancer patients treated with a total mesorectal ..
  76. ncbi External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing
    Mala Chakraborty
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 64:4328-37. 2004
    ..The model used consisted of mice transgenic for human carcinoembryonic antigen (CEA) and a murine carcinoma cell line transfected with CEA...
  77. pmc Prospective validation of quantitative CEA mRNA detection in peritoneal washes in gastric carcinoma patients
    S Ito
    1Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Br J Cancer 93:986-92. 2005
    ..The present study prospectively validates the prognostic ability of quantifying carcinoembryonic antigen (CEA) mRNA in peritoneal washes by real-time reverse transcriptase-polymerase chain reaction...
  78. ncbi beta 1,3-Galactosyltransferase beta 3Gal-T5 acts on the GlcNAcbeta 1-->3Galbeta 1-->4GlcNAcbeta 1-->R sugar chains of carcinoembryonic antigen and other N-linked glycoproteins and is down-regulated in colon adenocarcinomas
    R Salvini
    Department of Biochemistry, University of Pavia, via Taramelli 3b, 27100 Pavia, Italy
    J Biol Chem 276:3564-73. 2001
    ..Moreover, recombinant carcinoembryonic antigen purified from a CHO clone expressing Fuc-TIII and beta3Gal-T5 reacts with anti-sialyl-Lewis a and carries ..
  79. ncbi A measles virus vaccine strain derivative as a novel oncolytic agent against breast cancer
    Cari J McDonald
    Molecular Medicine Program, Mayo Clinic, Rochester, MN, USA
    Breast Cancer Res Treat 99:177-84. 2006
    ..strain of measles virus deriving from the Edmonston vaccine lineage, genetically engineered to produce carcinoembryonic antigen (CEA) against breast cancer...
  80. ncbi Expression of the carcinoembryonic antigen gene is inhibited by SOX9 in human colon carcinoma cells
    Philippe Jay
    Institut de Genetique Humaine, Centre National de la Recherche Scientifique UPR1142, Montpellier, France
    Cancer Res 65:2193-8. 2005
    The human carcinoembryonic antigen (CEA) is overexpressed in many types of human cancers and is commonly used as a clinical marker. In colon cancer, this overexpression protects cells against apoptosis and contributes to carcinogenesis...
  81. ncbi Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer
    A Arabzadeh
    Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada
    Oncogene 32:849-60. 2013
    ..b>Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a cell adhesion molecule with reduced expression in early ..
  82. ncbi A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk
    Meian He
    MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Gut 63:143-51. 2014
    ..We aimed to identify genetic loci that influence concentrations of cancer antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) and α fetoprotein (AFP), and investigated the associations between the significant single ..
  83. ncbi The usefulness of CEA and/or CA19-9 in monitoring for recurrence in gastric cancer patients: a prospective clinical study
    Yutaka Takahashi
    Japanese Foundation for Multidisciplinary Treatment of Cancer, Ichigaya MS Bldg, 1 9, 4 chome, Kudankita, Chiyoda ku, Tokyo 102 0073, Japan
    Gastric Cancer 6:142-5. 2003
    Many studies on postoperative carcinoembryonic antigen (CEA) and/or carbohydrate antigen (CA)19-9 monitoring after operation for gastric cancer have been reported, but most have been retrospective.
  84. ncbi Diagnostic utility of pleural fluid carcinoembryonic antigen and CYFRA 21-1 in patients with pleural effusion: a systematic review and meta-analysis
    Ping Gu
    Nuclear Department, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    J Clin Lab Anal 21:398-405. 2007
    ..A large number of studies exploring the role of carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21-1) marker in differential diagnosis of PE have been published,..
  85. ncbi Cystic pancreatic neuroendocrine tumors: endoscopic ultrasound and fine-needle aspiration characteristics
    W J Yoon
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endoscopy 45:189-94. 2013
    ..The aims of this study were to describe the EUS and FNA characteristics of pathologically confirmed CPanNets and to compare these characteristics with mucinous cysts from matched patients...
  86. ncbi Antitumor activity of chimeric immunoreceptor gene-modified Tc1 and Th1 cells against autologous carcinoembryonic antigen-expressing colon cancer cells
    Takeshi Sasaki
    Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Cancer Sci 97:920-7. 2006
    ..Tc1 and Th1 cells applicable for many cancer patients, we previously developed a protocol for generating carcinoembryonic antigen (CEA)-specific Tc1 and Th1 cells from healthy human T cells by transduction with a lentivirus containing ..
  87. ncbi Prospective evaluation of carcinoembryonic antigen (CEA) and carbohydrate antigen 15.3 (CA 15.3) in patients with primary locoregional breast cancer
    Rafael Molina
    Laboratory of Clinical Biochemistry Unit for Cancer Research, Hospital Clinic, Medical School, Barcelona, Spain
    Clin Chem 56:1148-57. 2010
    The utility of carcinoembryonic antigen (CEA) and carbohydrate antigen 15.3 (CA 15.3) as prognostic factors in primary breast cancer is unclear.
  88. ncbi Signal amplification in molecular imaging by pretargeting a multivalent, bispecific antibody
    Robert M Sharkey
    Garden State Cancer Center, Center for Molecular Medicine and Immunology, 520 Belleville Avenue, Belleville, New Jersey 07109, USA
    Nat Med 11:1250-5. 2005
    ..using signal amplification of a radiotracer in situ by pretargeting a multivalent, bispecific antibody to carcinoembryonic antigen (CEA), which subsequently also captures a radioactive hapten-peptide...
  89. pmc A pilot safety trial investigating a vector-based vaccine targeting carcinoembryonic antigen in combination with radiotherapy in patients with gastrointestinal malignancies metastatic to the liver
    James L Gulley
    National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Tumor Immunology and Biology, 10 Center Dr, 8B09 MSC 1750, Bethesda, MD 20892, USA
    Expert Opin Biol Ther 11:1409-18. 2011
    ..This pilot study evaluated the tolerability of a vector-based vaccine targeting carcinoembryonic antigen (CEA) in combination with radiation therapy in patients with gastrointestinal malignancies metastatic to ..
  90. ncbi CEA-based vaccines
    Emina H Huang
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Expert Rev Vaccines 1:49-63. 2002
    b>Carcinoembryonic antigen (CEA), the first tumor-associated antigen to be described, was cloned in 1987 and is expressed on nearly 50% of all human tumors...
  91. ncbi Protein epitopes in carcinoembryonic antigen. Report of the ISOBM TD8 workshop
    J Bjerner
    Central Laboratory, Norwegian Radium Hospital, Oslo, Norway
    Tumour Biol 23:249-62. 2002
    To characterize antigenic sites in carcinoembryonic antigen (CEA) further and to investigate whether there are differences between colon tumor CEA and meconium CEA (NCA-2) that can be detected by anti-CEA monoclonal antibodies (MAb), 19 ..
  92. pmc Clinical value of serum HMGB1 levels in early detection of recurrent squamous cell carcinoma of uterine cervix: comparison with serum SCCA, CYFRA21-1, and CEA levels
    Xiugui Sheng
    Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, People s Republic of China
    Croat Med J 50:455-64. 2009
    ..making the early diagnosis of recurrent cervical squamous cell carcinomas (CSCC) and compare it with the value of serum squamous cell carcinoma antigen (SCCA), cytokeratin fragment (CYFRA) 21-1, and carcinoembryonic antigen (CEA) levels.
  93. ncbi Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level
    In Ja Park
    Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Korea
    Ann Surg Oncol 16:3087-93. 2009
    We evaluated preoperative serum carcinoembryonic antigen (CEA) as a prognostic factor for colorectal cancer and determined when surveillance of this marker was useful.
  94. pmc Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer
    Hye Won Chung
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Transl Med 7:38. 2009
    ..We investigated the correlation between the serum HMGB1 levels and the clinical and pathologic features of gastric cancer and evaluated the validity of HMGB1 as a potential biomarker for the early diagnosis of gastric cancer...
  95. ncbi Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zeta-based chimeric immune receptors
    David E Gilham
    CRC Department of Medical Oncology, Paterson Institute for Cancer Research, University of Manchester, UK
    J Immunother 25:139-51. 2002
    ..Viability was improved by a costimulatory signal indicating that such signals may be vital in the maintenance of long-term functional activity of receptor modified T lymphocytes...
  96. ncbi Early postoperative CEA level is a better prognostic indicator than is preoperative CEA level in predicting prognosis of patients with curable colorectal cancer
    Jen Kou Lin
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, No 201, Section 2, Shih Pai Road Taipei, 11217, Taipei, Taiwan
    Int J Colorectal Dis 26:1135-41. 2011
    b>Carcinoembryonic antigen (CEA) measurements performed preoperatively and during the early postoperative period were examined prospectively to assess their prognostic value for colorectal cancer (CRC) patients receiving curative surgery.
  97. ncbi Serum tumor markers as predictors for survival in advanced non-small cell lung cancer patients treated with gefitinib
    Chao Hua Chiu
    Section of Thoracic Oncology, Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Lung Cancer 57:213-21. 2007
    ..Though the imaging-based response (IBR) is the most frequently used index of the therapeutic effect in cancer patients, an index based on serum tumor markers might prove to be useful, especially in patients without measurable tumors...
  98. pmc Prediction of survival and recurrence by serum and cytosolic levels of CEA, CA125 and SCC antigens in resectable non-small-cell lung cancer
    M Diez
    San Carlos University Hospital, Madrid, Spain
    Br J Cancer 73:1248-54. 1996
    ..non-small-cell lung cancer patients were analysed with respect of TNM stage, histological type and carcinoembryonic antigen (CEA), CA125 antigen and squamous cell carcinoma antigen (SCC) levels in serum and cytosol...
  99. pmc Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow
    Susan N Thomas
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 283:15647-55. 2008
    ..Using immunoaffinity chromatography and tandem mass spectrometry, we identify this glycoprotein as the carcinoembryonic antigen (CEA)...
  100. pmc Prognostic significance of CTCs and CSCs of tumor drainage vein blood in Dukes' stage B and C colorectal cancer patients
    Ryu Shimada
    Department of Surgery, Teikyo University School of Medicine, Tokyo 173 0003, Japan
    Oncol Rep 27:947-53. 2012
    ..In this study, we investigated the prognostic value of CTC/CSC that express carcinoembryonic antigen (CEA) cytokeratin 19 (CK19), CK20 and/or CD133 (CEA/CK/CD133) mRNA in the tumor drainage ..
  101. ncbi Diagnostic utility of serum and pleural fluid carcinoembryonic antigen, neuron-specific enolase, and cytokeratin 19 fragments in patients with effusions from primary lung cancer
    Jin Hwa Lee
    Department of Internal Medicine, Ewha Womans University, Ewha Medical Research Institute, 911 1 MokDong, Yangcheon Ku, Seoul, South Korea
    Chest 128:2298-303. 2005
    To assess the diagnostic values of carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and cytokeratin 19 fragments (CYFRA 21-1) as markers of pleurisy in primary lung cancer.

Research Grants65

  1. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..Tumor cells expressing model tumor antigens, such as, ovalbumin (OVA) and carcinoembryonic antigen (CEA) will be used in these studies...
  2. Gene-Targeted Pro-Drug Therapy for Colorectal Cancer
    Hiremagalur N Jayaram; Fiscal Year: 2013
    ..To further increase the specificity, we will take advantage of the expression of carcinoembryonic antigen (CEA) by colorectal cancer cells and have designed an AAV2 vector where hNMNAT2 is driven by CEA...
  3. CEACAM1: A link between metabolic and cardiovascular diseases
    Sonia M Najjar; Fiscal Year: 2013
    ..The CarcinoEmbryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) regulates insulin sensitivity by promoting insulin clearance ..
  4. Measles Virotherapy and radiovirotherapy in the Treatment of recurrent gliomas
    Evanthia Galanis; Fiscal Year: 2013
    ..this approach into the first human clinical trial of a measles virus derivative producing human carcinoembryonic antigen, MV-CEA (CEA added to facilitate viral monitoring) in recurrent GBM patients...
  5. The role of CEACAM1 in CMV pathogenesis in the human placenta
    Takako Tabata; Fiscal Year: 2012
    ..CTBs express one of these regulators during invasion-carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-a member of the immunoglobulin superfamily...
  6. Alcohol-altered CEA processing: Role in liver metastases in colorectal cancer
    Peter Thomas; Fiscal Year: 2013
    ..application is to examine how ethanol exposure can lead to altered processing and degradation of carcinoembryonic antigen (CEA), a glycoprotein secreted by tumor cells, and whose increase in the circulation has been linked to ..
  7. Structure and dynamics of bacterial membrane protein - receptor interactions
    LINDA M COLUMBUS; Fiscal Year: 2013
    ..The larger class, OpaCEA, bind to carcinoembryonic antigen-like cellular adhesion molecules (CEACAMs), and the smaller class, OpaHS, bind to two different receptors;..
  8. Optimizing Measles Virotherapy in the Treatment of Ovarian Cancer
    Kah Whye Peng; Fiscal Year: 2012
    ..to translate this approach into a phase I clinical trial of a measles virus derivative producing human carcinoembryonic antigen, MV-CEA (CEA added to facilitate monitoring of viral gene expression) in recurrent ovarian cancer ..
  9. Regulation of Mucosal Lymphocytes
    Richard S Blumberg; Fiscal Year: 2013
    ..This research proposal addresses the unanswered question of how carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is regulated and in turn regulates intestinal immune responses...
  10. Development of a gold nanoparticles based targeted delivery system
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..all the pancreatic tumor cells or patients that do not express EGFR, we may use other targets such as carcinoembryonic antigen (CEM) or carbohydrate antigen 19-9 (CA-19-9) or need to further identify other targeting molecules and ..
  11. Histopathologic and Immunohistochemical Features of Tissue Adherent to the Electr
    CONSTANTINOS THASOS SOFOCLEOUS; Fiscal Year: 2011
    ..ablated tumor (adherent to the electrode and obtained with needle biopsy) with peripheral blood levels of carcinoembryonic antigen (CEA)...
  12. CEACAM-1a regulates graft-versus-host-disease after allogeneic HSCT
    Marcel R m van den Brink; Fiscal Year: 2010
    b>Carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM-1) is a transmembrane protein found on leukocytes, endothelium, and epithelium. Its activation can attenuate colitis in murine models...
  13. PTD-Mediated Protein or Drug Delivery for Cancer Therapy
    Victor C Yang; Fiscal Year: 2013
    ..Recent advancement in colorectal cancer research seems to offer a solution to these two issues. First, carcinoembryonic antigen (CEA), a surface antigen known to associate with tumor growth/metastasis, was shown to be overly ..
  14. Defining Secreted Glycan Alterations in Pancreatic Cancer
    Brian B Haab; Fiscal Year: 2010
    ..This research could lead to significantly improved blood tests for the detection of cancer, as well as a powerful, generally- applicable platform for studying carbohydrate alterations on multiple proteins. ..
  15. Therapeutic Vaccine for HIV/HPV-associated Oropharyngeal and Tonsillar Malignanci
    FRANK R JONES; Fiscal Year: 2011
    ..In a murine cancer model employing the carcinoembryonic antigen (CEA) gene insert, tl...
  16. Development of a Novel CEA Expressing Ad5 [E1-, E2b-] Vector for Treatment
    FRANK R JONES; Fiscal Year: 2010
    ..information and lead to clinical trials of a new drug (Ads [E1-, E2b-]-CEA) to treat cancers which have carcinoembryonic antigen on their surface. The drug is needed to induce a greater immune response against certain cancers.
  17. F-18 Labeled Peptides for Pretargeted PET Imaging of Pancreatic Cancer
    WILLIAM JOHN MCBRIDE; Fiscal Year: 2010
    ..Most of the preclinical work has been done with a bsMab that binds to the colo-rectal tumor marker carcinoembryonic antigen and HSG...
  18. TAS::75 0849 - TOPIC 255 PHASE II, CGMP MANUFACTURE OF A NOVEL CEA EXPRESSING A
    FRANK R JONES; Fiscal Year: 2011
    Etubics Corporation is clinically testing a new vaccine targeting carcinoembryonic antigen (CEA) expressing cancers in a Phase I/II clinical trials under FDA IND14325...
  19. DEVELOPMENT AND CONTROL OF PULMONARY ALVEOLAR STABILITY
    Samuel Hawgood; Fiscal Year: 2013
    ..Project 2: Expression and role of CEACAM6 in the alveolus. To investigate the role of carcinoembryonic antigen-6 in alveolar innate immune defense, surfactant function, and epithelial response to acute lung injury...
  20. Nanofluidic Flow Proteometry for the Determination of Cancer Biomarker Concentrat
    Jun Kameoka; Fiscal Year: 2010
    ..Currently, multiple serum-based breast cancer biomarkers such as CA15-3, BR27.29 (CA27.29), carcinoembryonic antigen, tissue polypeptide antigen, and HER2 (extra cellular domain) are being investigated as indicators of ..
  21. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 2002
    We have generated a murine monoclonal anti-idiotype ( antibody, 3Hl, that is the internal image of the carcinoembryonic antigen (CEA)...
  22. Mechanisms of Host Responses in Gonorrhea
    Tie Chen; Fiscal Year: 2006
    ..and phagocytosis in epithelial cells and neutrophils in part through interaction with members of the carcinoembryonic antigen family (CEA, CEACAM, or CD66), CEACAM3 (CD66d) and CEACAM1 (CD66a)...
  23. PRE-TARGETED GALLIUM-68 POSITRON EMISSION TOMOGRAPHY
    Gary Griffiths; Fiscal Year: 1999
    ..We will iodine-l25 label an anti-carcinoembryonic antigen complementarity determining region-grafted x murine antidiethylenetriaminepentaacatec acid bispecific F(..
  24. Cell-type specific targting of curcumin
    BIDDANDA PONNAPPA; Fiscal Year: 2005
    ..Recent studies show that curcumin has both anti-inflammatory and anti-cancer properties. Carcinoembryonic antigen (CEA), a glycosylated protein secreted by tumor cells, has been implicated in the development of hepatic ..
  25. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
    b>Carcinoembryonic antigen (CEA) is an intercellular adhesion molecule that plays a major role in colon tumorigenesis. We have identified a novel protein on human monocytes that binds to CEA...
  26. Rational Design of Therapeutic Vaccines for CEA+ Tumors
    SUNIL CHATTERJEE; Fiscal Year: 2007
    ..suggest that vaccination with an anti-idiotype (Id) antibody (3H1) that mimics an epitope of human carcinoembryonic antigen (CEA) has the potential to augment survival benefits...
  27. ANTIGEN PRESENTATION BY CEA DIRECTED TUMOR VACCINES
    Howard Kaufman; Fiscal Year: 2003
    b>Carcinoembryonic antigen (CEA) is a common tumor-associated antigen. Several T-cell specific epitopes have been identified within the terminal repeat domains of CEA, suggesting that CEA may be a target for vaccine development...
  28. SELECTIVE RADIOIMMUNOTHERAPY OF COLON CANCER
    David Goldenberg; Fiscal Year: 1980
    ..design and synthesis of boron-containing compounds capable of labeling immunoglobulins prepared against carcinoembryonic antigen (CEA) with the retention of immunoreactivity...
  29. RADIOIMMUNOTHERAPY OF ADVANCED REFRACTORY OVARIAN CANCER
    Malik Juweid; Fiscal Year: 1999
    ..EOC is known to produce carcinoembryonic antigen (CEA)...
  30. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    Lopa Mishra; Fiscal Year: 2010
    ..produced by the host liver as arresting tumor cells create an ischemia/reperfusioninjury, 2) CRC release Carcinoembryonic Antigen (CEA), a 180 kDa glycoprotein, that binds to heterogeneous RNA-binding protein M4 on Kupffer cells (the ..
  31. TFF3 GENE EXPRESSION IN METASTATIC COLON CANCER
    Steven Itzkowitz; Fiscal Year: 2001
    ..We have also demonstrated that placing the suicide gene under the control of the carcinoembryonic antigen (CEA) promoter affords greater tissue specificity...
  32. STRUCTURE/FUNCTION OF A HEPATIC CEA BINDING PROTEIN
    Peter Thomas; Fiscal Year: 2000
    b>Carcinoembryonic antigen (CEA) is involved in the development of hepatic metastases from colorectal cancers. The major hepatic CEA binding protein is 80kD Kupffer cell surface molecule...
  33. RECOMBINANT TUMOR VACCINE--CATBRM
    Albert LoBuglio; Fiscal Year: 1999
    ..The program is currently carrying out a phase Ib trial of recombinant vaccinia-carcinoembryonic antigen (CEA) immunization in resected Dukes' C colorectal cancer patients and a phase I trial of baculovirus ..
  34. SELECTED MARKERS IN NONINVASIVE BLADDER TUMORS
    FRITZ HERZ; Fiscal Year: 1992
    ..The value of additional markers, carcinoembryonic antigen, nuclear proliferation antigen and placental alkaline phosphatase will be explored...
  35. Immunotherapy with TRICOM Modified Dendritic Cells
    Herbert Lyerly; Fiscal Year: 2002
    ..we have demonstrated that fowlpox engineered to express B7- 1, ICAM-1 and LFA-3 and the tumor antigen carcinoembryonic antigen (CEA) can infect human DC, express these molecules and stimulate CEA specific T cells in vitro...
  36. OPTICAL BIOSENSOR FOR THE EARLY DETECTION OF CANCER
    BASIL SWANSON; Fiscal Year: 2002
    ..is based on the ultrasensitive and specific detection of the tumor specific antigens, including CEA (carcinoembryonic antigen), MUC-l (CA15...
  37. SECRETORY DIARRHEA--CELLULAR MECHANISMS
    Jonathan Cohn; Fiscal Year: 1992
    ..6/ Develop a brush border membrane preparation procedure for T84 cells using carcinoembryonic antigen as a marker...
  38. Novel dendritic cell therapy for human cancers
    Selvarangan Ponnazhagan; Fiscal Year: 2005
    ..The goals of this project are to optimize DC transduction by rAAV encoding a tumor antigen, carcinoembryonic antigen (CEA), to achieve potent T cell responses and to evaluate the efficacy of rAAV-CEA transduced DCs in ..
  39. F-18 FDG Peptides for Pretargeted PET Imaging of Pancrea
    William McBride; Fiscal Year: 2005
    ..Most of the preclinical work has been done with a bsMab that binds to the colo-rectal tumor marker carcinoembryonic antigen and HSG...
  40. IMMUNODIAGNOSTIC APPROACHES TO HUMAN BREAST CANCER
    Donald Kufe; Fiscal Year: 1990
    ..which detects the CA15-3 antigen, has recently been shown to be more sensitive than the currently used carcinoembryonic antigen assay for the evaluation and monitoring of patients with breast cancer...
  41. Molecular Detection of Occult Metastases in Lung Cancer
    Tony Godfrey; Fiscal Year: 2006
    ..Thus, in Specific Aims 1 and 2 of this proposal, we will use QRT-PCR for carcinoembryonic antigen (CEA) and cytokeratin 19 (CK 19) to detect micrometastases in the lymph nodes, blood and bone marrow of ..
  42. CANARYPOX VACCINE EXPRESSIONG CEA AND B7
    Howard Kaufman; Fiscal Year: 1999
    ..Applicant's Description) Nearly 500,000 patients are diagnosed annually with solid tumors that express carcinoembryonic antigen (CEA)...
  43. MOLECULAR DISSECTION OF THE CORONAVIRUS SPIKE
    Thomas Gallagher; Fiscal Year: 2007
    ..S proteins bind to carcinoembryonic antigen-related cell adhesion molecule (CEACAM) receptors, which cause conformational changes culminating in ..
  44. CEA directed cancer treatment with gene-modified T cells
    Mark McKee; Fiscal Year: 2007
    ..In his proposed research, he will study the biology and genetics of T cells that recognize carcinoembryonic antigen (CEA)...
  45. Evaluation of the Vaccine rF-CEA(6D)/TRICOM +/-GM-CSF
    Margaret von Mehren; Fiscal Year: 2002
    ..Specifically, a vaccine model vaccinating against the tumor associated antigen carcinoembryonic antigen (CEA) demonstrated an increase in the CEA-specific T-cell response using a vaccine with the three ..
  46. 12th International CEA/PSG Symposium
    Douglas Hixson; Fiscal Year: 2001
    ..together clinical and basic scientists from all parts of the world to discuss the latest research on the carcinoembryonic antigen (CEA) family of immunoglobulin-like cell adhesion molecules...
  47. TISSUE ENGINEERING TO CREATE LIVING EPIDERMAL BIOSENSORS
    PAULINE SCHWARTZ; Fiscal Year: 2000
    ..A single chain Fv (scFv) antibody with high affinity to carcinoembryonic antigen (CEA) will serve as the ligand binding domain of the chimeric receptor...
  48. CEA DENTRITIC CELL VACCINE FOR COLORECTAL CANCER
    Frank Scappaticci; Fiscal Year: 2002
    ..a dendritic cell-based vaccine in order to elicit a humoral and cell-mediated cytotoxic response against carcinoembryonic antigen (CEA) expressing tumor cells...
  49. SOCIAL BEHAVIOR OF CULTURED COLON ADENOCARCINOMA CELLS
    LYNNE RUTZKY; Fiscal Year: 1980
    ..The criteria upon which the clones are evaluated include: 1) morphology, 2) carcinoembryonic antigen and mucin production, 3) tumor induction in nude mice, 4) colony formation in soft agar, 5) population ..
  50. Molecular Imaging by Affinity Enhancement PET
    Gary Griffiths; Fiscal Year: 2003
    ..I application will explore the feasibility of using a bispecific antibody construct, targeted against the carcinoembryonic antigen, and up-regulated in many cancers, as an agent to selectively place a secondary binding arm specifically ..
  51. IMMUNOTHERAPY OF CANCER WITH ANTIID BASED DNA VACCINE
    SUNIL CHATTERJEE; Fiscal Year: 1999
    ..Our anti-Id, 3H1, which resembles an epitope of the carcinoembryonic antigen (CEA), acts as a surrogate for CEA, and we have completed a phase Ib trial of colon cancer patients with ..
  52. High-avidity multimeric cancer imaging agent
    Anna Wu; Fiscal Year: 2005
    ..As a model system, single chain antibodies specific for carcinoembryonic antigen (CEA) will be reformatted to generate dimers and tetramers...
  53. Dendritic Cell Subset for Enhanced Cancer Vaccine
    Douglas Smith; Fiscal Year: 2004
    ..Well-defined and clinically applicable cytomegaloviral (CMV)and tumor-associated carcinoembryonic antigen (CEA) peptide epitopes will be used to characterize theCD4+ and CD8+ T-cell responses to these DC ..
  54. ANTICEA IGTCR MODIFIED T CELLS FOR CANCER THERAPY
    Richard Junghans; Fiscal Year: 2000
    b>Carcinoembryonic antigen (CEA) is expressed as a tumor-associated antigen in a large number of human malignancies...
  55. ANTIBODY MICROARRAY FOR DETECTION OF TUMOR MARKERS
    Michael Wilson; Fiscal Year: 2002
    ..the simultaneous detection and quantification of two tumor markers, prostate-specific antigen (PSA) and carcinoembryonic antigen (CEA) using SMAI in order to provide proof-of-concept validation of our antibody microarray system...
  56. IMMUNOCHEMICAL STUDIES OF GASTROINTESTINAL CANCER
    Elliot Alpert; Fiscal Year: 1980
    ..tumor associated carcinofetal antigens, alpha-1-fetoprotein (AFP), beta-fetoprotein or ferritin, and carcinoembryonic antigen (CEA), have demonstrated these markers to be of definite, although limited, diagnostic or prognostic ..
  57. Colonic Cells:Non-Invasive Isolation Technology
    Padmanabhan Nair; Fiscal Year: 2003
    ..C. The outcome measures are PCR amplicons of CD 44 splice variants and tumor specific variants of carcinoembryonic antigen (CEA)...
  58. FUSION PROTEINS AGAINST CARCINOEMBRYONIC ANTIGEN
    F Primus; Fiscal Year: 2003
    ..fusion proteins for the targeting of cytokines and/or co-stimulatory molecules to tumors expressing carcinoembryonic antigen (CEA) for immunotherapy. These studies will use a high affinity anti-CEA Mab, T84...
  59. HERPESVIRUS-ASSOCIATED MALIGNANCIES IN HIV PATIENTS
    Richard Ambinder; Fiscal Year: 2003
    ..The overall objective of this program project grant is to define the clinical role of radiolabeled, genetically engineered antibodies directed against anti- carcinoembryonic antigen (CEA).
  60. Suppression of EAE by placentally derived glycoprotein
    Larry Sherman; Fiscal Year: 2005
    ..PSGs are members of the carcinoembryonic antigen (CEA) family, which in turn belong to the immunoglobulin superfamily of proteins...
  61. Defining Secreted Glycan Alterations in Pancreatic Cancer
    Brian Haab; Fiscal Year: 2006
    ..This research could lead to significantly improved blood tests for the detection of cancer, as well as a powerful, generally- applicable platform for studying carbohydrate alterations on multiple proteins. ..
  62. MANAGEMENT OF CANCER WITH MONOCLONAL ANTIBODIES
    David Gold; Fiscal Year: 2000
    ..In the previous year, a humanized antibody to carcinoembryonic antigen was developed and tested...
  63. ROLE OF MAPK'S AND TGFBETA MEDIATED CELLULAR RESPONSES
    KATHLEEN MULDER; Fiscal Year: 1999
    ..protein fibronectin and its receptors (integrins), induction of the colon cell differentiation marker carcinoembryonic antigen, and modulation of gene expression...
  64. DENDRITIC CELL IMMUNOTHERAPY FOR LUNG AND COLON CANCER
    Lawrence Fong; Fiscal Year: 2003
    ..issues in DC immunotherapy in patients with lung and colorectal tumors with a peptide derived from carcinoembryonic antigen (CEA) as the immunologic target...
  65. DEXASOME BASED IMMUNOTHERAPY OF LUNG CANCER
    Michael Morse; Fiscal Year: 2002
    ..This clinical trial will form the background for further trials designed to demonstrate both immunology and clinical benefits of dexosome-based immunotherapy. ..