carcinoembryonic antigen

Summary

Summary: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.

Top Publications

  1. ncbi ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer
    Gershon Y Locker
    American Society of Clinical Oncology Tumor Markers Expert Panel, Alexandria, VA 22314, USA
    J Clin Oncol 24:5313-27. 2006
  2. pmc Pretargeted immuno-positron emission tomography imaging of carcinoembryonic antigen-expressing tumors with a bispecific antibody and a 68Ga- and 18F-labeled hapten peptide in mice with human tumor xenografts
    Rafke Schoffelen
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Cancer Ther 9:1019-27. 2010
  3. pmc T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
    Maria R Parkhurst
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 19:620-6. 2011
  4. doi Carcinoembryonic antigen (CEA) as tumor marker in lung cancer
    M Grunnet
    Department of Oncology, National University Hospital, Copenhagen, Denmark
    Lung Cancer 76:138-43. 2012
  5. ncbi Decline in serum carcinoembryonic antigen and cytokeratin 19 fragment during chemotherapy predicts objective response and survival in patients with advanced nonsmall cell lung cancer
    Andrea Ardizzoni
    Division of Medical Oncology, University Hospital of Parma, Parma, Italy
    Cancer 107:2842-9. 2006
  6. doi Toward standardized high-throughput serum diagnostics: multiplex-protein array identifies IL-8 and VEGF as serum markers for colon cancer
    Stefanie Bünger
    Laboratory for Surgical Research, Department of Surgery, University of Lubeck, Germany
    J Biomol Screen 16:1018-26. 2011
  7. ncbi Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter
    Kosei Hasegawa
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 12:1868-75. 2006
  8. ncbi Prognostic value of carcinoembryonic antigen and CYFRA21-1 in patients with pathological stage I non-small cell lung cancer
    Katsunari Matsuoka
    Department of Thoracic Surgery, Japanese Red Cross Society Wakayama Medical Center, Japan
    Eur J Cardiothorac Surg 32:435-9. 2007
  9. pmc Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Cancer Res 65:622-31. 2005
  10. doi Progression of medullary thyroid carcinoma: assessment with calcitonin and carcinoembryonic antigen doubling times
    Anne Laure Giraudet
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy and University Paris Sud, 94805 Villejuif Cedex, France
    Eur J Endocrinol 158:239-46. 2008

Research Grants

  1. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2010
  2. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2009
  3. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2010
  4. Histopathologic and Immunohistochemical Features of Tissue Adherent to the Electr
    Constantinos Sofocleous; Fiscal Year: 2009
  5. Development of a gold nanoparticles based targeted delivery system
    Priyabrata Mukherjee; Fiscal Year: 2010
  6. Development of a gold nanoparticles based targeted delivery system
    Priyabrata Mukherjee; Fiscal Year: 2009
  7. Optimizing Measles Virotherapy in the Treatment of Recurrent Ovarian Cancer
    Evanthia Galanis; Fiscal Year: 2009
  8. Tumor-specific agents for cancer imaging
    MARIA DA GRACA HENRIQUES VICENTE; Fiscal Year: 2010
  9. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 2001
  10. Active Immunotherapy with Pox Vector Modified DC
    Michael Morse; Fiscal Year: 2004

Detail Information

Publications319 found, 100 shown here

  1. ncbi ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer
    Gershon Y Locker
    American Society of Clinical Oncology Tumor Markers Expert Panel, Alexandria, VA 22314, USA
    J Clin Oncol 24:5313-27. 2006
    ..To update the recommendations for the use of tumor marker tests in the prevention, screening, treatment, and surveillance of gastrointestinal cancers...
  2. pmc Pretargeted immuno-positron emission tomography imaging of carcinoembryonic antigen-expressing tumors with a bispecific antibody and a 68Ga- and 18F-labeled hapten peptide in mice with human tumor xenografts
    Rafke Schoffelen
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Cancer Ther 9:1019-27. 2010
    ..Mice were implanted with carcinoembryonic antigen (CEA; CEACAM5)-expressing LS174T human colonic tumors and a CEA-negative tumor, or an inflammation was ..
  3. pmc T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
    Maria R Parkhurst
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 19:620-6. 2011
    Autologous T lymphocytes genetically engineered to express a murine T cell receptor (TCR) against human carcinoembryonic antigen (CEA) were administered to three patients with metastatic colorectal cancer refractory to standard treatments...
  4. doi Carcinoembryonic antigen (CEA) as tumor marker in lung cancer
    M Grunnet
    Department of Oncology, National University Hospital, Copenhagen, Denmark
    Lung Cancer 76:138-43. 2012
    ..Future studies may benefit from evaluating more than one marker at a time, which may possibly create a more precise index for prognosis and recurrence in lung cancer, than is possible by the use of single biomarkers...
  5. ncbi Decline in serum carcinoembryonic antigen and cytokeratin 19 fragment during chemotherapy predicts objective response and survival in patients with advanced nonsmall cell lung cancer
    Andrea Ardizzoni
    Division of Medical Oncology, University Hospital of Parma, Parma, Italy
    Cancer 107:2842-9. 2006
    The authors assessed the predictive and prognostic role of decline in the serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA 21-1) during chemotherapy in patients with advanced nonsmall cell lung cancer (..
  6. doi Toward standardized high-throughput serum diagnostics: multiplex-protein array identifies IL-8 and VEGF as serum markers for colon cancer
    Stefanie Bünger
    Laboratory for Surgical Research, Department of Surgery, University of Lubeck, Germany
    J Biomol Screen 16:1018-26. 2011
    ..protein array, the authors explore a panel of cytokines simultaneously and compared its performance to carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9)...
  7. ncbi Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter
    Kosei Hasegawa
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 12:1868-75. 2006
    ..being tested in patients with ovarian cancer and whose propagation can be monitored by measuring blood carcinoembryonic antigen (CEA) levels...
  8. ncbi Prognostic value of carcinoembryonic antigen and CYFRA21-1 in patients with pathological stage I non-small cell lung cancer
    Katsunari Matsuoka
    Department of Thoracic Surgery, Japanese Red Cross Society Wakayama Medical Center, Japan
    Eur J Cardiothorac Surg 32:435-9. 2007
    The aim of this retrospective study was to assess the prognostic value of serum tumor markers (carcinoembryonic antigen (CEA) and CYFRA21-1) in patients with pathologic (p-) stage I non-small cell lung cancer (NSCLC) undergoing complete ..
  9. pmc Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Cancer Res 65:622-31. 2005
    ..the half-life of engineered antibodies, we have mutated the Fc-FcRn binding site of chimeric anti-carcinoembryonic antigen (CEA) antibodies produced in a single-chain Fv-Fc format. The anti-CEA T84...
  10. doi Progression of medullary thyroid carcinoma: assessment with calcitonin and carcinoembryonic antigen doubling times
    Anne Laure Giraudet
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy and University Paris Sud, 94805 Villejuif Cedex, France
    Eur J Endocrinol 158:239-46. 2008
    The progression of medullary thyroid cancer is difficult to assess with imaging modalities; we studied the interest of calcitonin and carcinoembryonic antigen (CEA) doubling times and of Ki-67 labeling and mitotic index (MI).
  11. ncbi Use of a vaccine strain of measles virus genetically engineered to produce carcinoembryonic antigen as a novel therapeutic agent against glioblastoma multiforme
    Loi K Phuong
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 63:2462-9. 2003
    ..of measles virus (MV), derived from the Edmonston vaccine lineage, genetically engineered to produce carcinoembryonic antigen (CEA). CEA production as the virus replicates can serve as a marker of viral gene expression...
  12. pmc Phase I trial of intraperitoneal administration of an oncolytic measles virus strain engineered to express carcinoembryonic antigen for recurrent ovarian cancer
    Evanthia Galanis
    Division of Medical Oncology, Department of Molecular Medicine, Mayo Clinic, Gonda 10 141, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Res 70:875-82. 2010
    ..We engineered MV to express the marker peptide carcinoembryonic antigen (MV-CEA virus) to also permit real-time monitoring of viral gene expression in tumors in the clinical ..
  13. pmc Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens
    Tim Schmitter
    Zentrum für Infektionsforschung, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Exp Med 199:35-46. 2004
    b>Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are used by several human pathogens to anchor themselves to or invade host cells...
  14. doi The role of carcinoembriogenic antigen in predicting response and survival to neoadjuvant chemoradiotherapy for distal rectal cancer
    Rodrigo O Perez
    Colorectal Surgery Division, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Dis Colon Rectum 52:1137-43. 2009
    ..Therefore, we hypothesized that a decrease in CEA after neoadjuvant chemoradiotherapy could reflect tumor response to chemoradiotherapy, affecting final disease stage and ultimately survival...
  15. doi Carcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgery
    Ji Won Park
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Republic of Korea
    Int J Radiat Oncol Biol Phys 74:810-7. 2009
    To evaluate the role of serum carcinoembryonic antigen (CEA) as a predictor of response to preoperative chemoradiotherapy (CRT) and prognostic factor for rectal cancer.
  16. ncbi Comparative toxicity and efficacy of combined radioimmunotherapy and antiangiogenic therapy in carcinoembryonic antigen-expressing medullary thyroid cancer xenograft
    Françoise Kraeber-Bodéré
    INSERM UMR 892 Cancer Research Center, Universite de Nantes, Nantes, France
    J Nucl Med 51:624-31. 2010
    A significant antitumor effect was previously observed with radioimmunotherapy using anti-carcinoembryonic antigen (131)I-F6 monoclonal antibody in medullary thyroid cancer-bearing nude mice...
  17. ncbi Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imaging
    Katy M Venisnik
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 9:267-77. 2007
    The bioluminescent protein Gaussia luciferase (GLuc) was fused to an anti-carcinoembryonic antigen (CEA) antibody fragment, the diabody, for in vivo optical tumor imaging...
  18. ncbi A measles virus vaccine strain derivative as a novel oncolytic agent against breast cancer
    Cari J McDonald
    Molecular Medicine Program, Mayo Clinic, Rochester, MN, USA
    Breast Cancer Res Treat 99:177-84. 2006
    ..strain of measles virus deriving from the Edmonston vaccine lineage, genetically engineered to produce carcinoembryonic antigen (CEA) against breast cancer...
  19. pmc Serum CYFRA 21-1 (cytokeratin-19 fragments) is a useful tumour marker for detecting disease relapse and assessing treatment efficacy in breast cancer
    B Nakata
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Br J Cancer 91:873-8. 2004
    ..The sera from 173 patients with primary breast cancer or recurrent disease were measured for CYFRA 21-1, carcinoembryonic antigen (CEA), and carbohydrate antigen 15-3 (CA 15-3) levels...
  20. pmc A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus
    D S Chen
    Howard Hughes Medical Institute, School of Medicine, University of Southern California, Los Angeles 90033 1054, USA
    Proc Natl Acad Sci U S A 92:12095-9. 1995
    ..cDNA library, we have identified a member of the pregnancy-specific glycoprotein (PSG) subgroup of the carcinoembryonic antigen gene family...
  21. pmc A pilot study of MUC-1/CEA/TRICOM poxviral-based vaccine in patients with metastatic breast and ovarian cancer
    Mahsa Mohebtash
    Medical Oncology Branch and Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 17:7164-73. 2011
    ..This study was conducted to obtain preliminary evidence of clinical response in metastatic breast and ovarian cancer patients...
  22. ncbi Prognostic value of combination of Cyfra 21-1, CEA and NSE in patients with advanced non-small cell lung cancer
    Fabrice Barlesi
    Faculty of Medicine, Universite de la Mediterranee, Assistance Publique Hopitaux de Marseille, Service d Oncologie Thoracique, Marseille, Cedex 09, France
    Respir Med 98:357-62. 2004
    ..To assess the value of Cyfra 21-1, carcino-embryonic antigen (CEA) and neuron-specific enolase (NSE) combined, all three together as prognostic factors in advanced stage non-small cell lung cancer (NSCLC) patients...
  23. doi Pretargeted 177Lu radioimmunotherapy of carcinoembryonic antigen-expressing human colonic tumors in mice
    Rafke Schoffelen
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 51:1780-7. 2010
    ..In this study, the optimization, therapeutic efficacy, and toxicity of PRIT of colon cancer with a (177)Lu-labeled peptide was determined in mice with carcinoembryonic antigen (CEA)-expressing human tumors.
  24. doi Clinical significance of CEA and CA19-9 in postoperative follow-up of colorectal cancer
    Tomomi Yakabe
    Faculty of Medicine, Department of Surgery, Saga University, Saga, Japan
    Ann Surg Oncol 17:2349-56. 2010
    ..We evaluated the efficiency of CEA and CA19-9 as tools for diagnosing recurrence in the postoperative surveillance of colorectal cancer...
  25. doi Cyst fluid carcinoembryonic antigen is an accurate diagnostic marker of pancreatic mucinous cysts
    Sevdenur Cizginer
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02116, USA
    Pancreas 40:1024-8. 2011
    ..The purpose of this investigation was to determine the most accurate test for differentiating mucinous from nonmucinous cysts...
  26. pmc Diagnostic performance of cyst fluid carcinoembryonic antigen and amylase in histologically confirmed pancreatic cysts
    Walter Gwang Up Park
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Pancreas 40:42-5. 2011
    ....
  27. pmc Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    Michael A Morse
    Department ofMedicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 112:610-8. 2008
    ..We then attempted to enhance antitumor immune responses in patients with carcinoembryonic antigen (CEA)-expressing malignancies by Treg-cell depletion...
  28. ncbi Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma
    Boris Blechacz
    Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA
    Hepatology 44:1465-77. 2006
    ..We evaluated recombinant MV-Edm expressing carcinoembryonic antigen (CEA) or the human sodium iodide symporter (hNIS) for oncolytic potential in hepatocellular carcinoma (..
  29. pmc Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis
    Oscar Arrieta
    Department of Medical Oncology, Instituto Nacional de Cancerologia, Mexico City, Mexico
    BMC Cancer 9:119. 2009
    ....
  30. ncbi Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC)
    Cedric N Berger
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 510, Faculte de Pharmacie Paris XI, F 92296 Chatenay Malabry, France
    Mol Microbiol 52:963-83. 2004
    ..recognize as receptors the GPI-anchored proteins CD55 (decay-accelerating factor, DAF) and CD66e (carcinoembryonic antigen, CEA)...
  31. doi Serum tumor markers CEA, CYFRA21-1, and CA-125 are associated with worse prognosis in advanced non-small-cell lung cancer (NSCLC)
    Susana Cedres
    Medical Oncology Department, Vall d Hebron University Hospital, Barcelona, Spain
    Clin Lung Cancer 12:172-9. 2011
    ..Serum tumor markers are considered a negative prognostic factor in early-stages NSCLC but its role in advanced disease is controversial. The aim of this study is to analyze the prognostic value of tumor markers in advanced NSCLC...
  32. ncbi Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer
    Mitchell J Goldstein
    Division of Neoplastic Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Invest 23:338-51. 2005
    ..Immunotherapy based on CEA is a rapidly advancing area of clinical research demonstrating antibody and T-cell responses...
  33. ncbi Isolated paraaortic lymph node recurrence after definitive irradiation for cervical carcinoma
    H H Chou
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Int J Radiat Oncol Biol Phys 51:442-8. 2001
    ..To evaluate the clinical features of isolated paraaortic lymph node (PALN) recurrence after definitive radiotherapy, and analyze the prognostic factors and effect of salvage treatment...
  34. ncbi Regulation of insulin action by CEACAM1
    Sonia M Najjar
    Department Pharmacology and Therapeutics, Medical College of Ohio, 3035 Arlington Ave, HSci Building, Room 270, Toledo, OH 43614, USA
    Trends Endocrinol Metab 13:240-5. 2002
    ..Earlier studies in transfected cells suggested that the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a substrate of the insulin receptor in liver, upregulates ..
  35. doi Protein expression of carcinoembryonic antigen cell adhesion molecules in benign and malignant melanocytic skin lesions
    Thilo Gambichler
    Dept of Dermatology and Allergology, Ruhr University Bochum, Germany
    Am J Clin Pathol 131:782-7. 2009
    ..nevi (BN), dysplastic nevi (DN), and primary superficial spreading melanoma (SSM) was performed for carcinoembryonic antigen (CEA) and CEA cell adhesion molecule-1 (CEACAM1) using monoclonal antibodies...
  36. ncbi Update of carcinoembryonic antigen radioimmunotherapy with (131)I-labetuzumab after salvage resection of colorectal liver metastases: comparison of outcome to a contemporaneous control group
    Torsten Liersch
    Department of General Surgery, University of Gottingen, Gottingen, Germany
    Ann Surg Oncol 14:2577-90. 2007
    ..Resection of LM from colorectal cancer is the standard of care in this setting, yet two thirds will eventually relapse, and adjuvant systemic chemotherapy has failed to improve survival...
  37. ncbi Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma
    Jacques Barbet
    Département de Recherche en Cancérologie, Institut National de la Sante et de la Recherche Medicale, Unite 601, Institut de Biologie, 9 quai Moncousu, 44093 Nantes Cedex 1, France
    J Clin Endocrinol Metab 90:6077-84. 2005
    ..After unsuccessful surgery, medullary thyroid carcinoma (MTC) may be fatal or remain stable for decades, and precise survival predictors are needed...
  38. ncbi Clinical parameters predicting pathologic tumor response after preoperative chemoradiotherapy for rectal cancer
    Sang Min Yoon
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
    Int J Radiat Oncol Biol Phys 69:1167-72. 2007
    ..To identify pretreatment clinical parameters that could predict pathologic tumor response to preoperative chemoradiotherapy (CRT) for rectal cancer...
  39. pmc Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways
    Oliver Billker
    Max Planck Institut für Infektionsbiologie, Abteilung Molekulare Biologie, Schumannstrasse 21 22, D 10117 Berlin, Germany
    EMBO J 21:560-71. 2002
    Opa adhesins of pathogenic Neisseria species target four members of the human carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) family...
  40. ncbi Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Department of Radioimmunotherapy, Duarte, CA, USA
    Cancer Res 67:718-26. 2007
    ..We studied the behavior of three anti-carcinoembryonic antigen (CEA) single-chain Fv-Fc (scFv-Fc) variants (I253A, H310A, and H310A/H435Q; Kabat numbering system) that ..
  41. ncbi SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms
    Takashi Nagaishi
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunity 25:769-81. 2006
    ..Thus, CEACAM1 overexpression or deletion in T cells resulted in T cell inhibition or activation, respectively, revealing a role for CEACAM1 as a class of inhibitory receptors potentially amenable to therapeutic manipulation...
  42. pmc Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors
    Shannon E McCaw
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Infect Immun 72:2742-52. 2004
    ..Neisseria gonorrhoeae colony opacity-associated (Opa) protein variants can bind up to four different carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) receptors...
  43. pmc A pilot safety trial investigating a vector-based vaccine targeting carcinoembryonic antigen in combination with radiotherapy in patients with gastrointestinal malignancies metastatic to the liver
    James L Gulley
    National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Tumor Immunology and Biology, 10 Center Dr, 8B09 MSC 1750, Bethesda, MD 20892, USA
    Expert Opin Biol Ther 11:1409-18. 2011
    ..This pilot study evaluated the tolerability of a vector-based vaccine targeting carcinoembryonic antigen (CEA) in combination with radiation therapy in patients with gastrointestinal malignancies metastatic to ..
  44. ncbi CEA-based vaccines
    Emina H Huang
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Expert Rev Vaccines 1:49-63. 2002
    b>Carcinoembryonic antigen (CEA), the first tumor-associated antigen to be described, was cloned in 1987 and is expressed on nearly 50% of all human tumors...
  45. pmc Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas
    S Schölzel
    Institutes of Molecular Medicine, University of Freiburg, Department of Surgery, University Hospital, Freiburg, Germany
    Am J Pathol 156:595-605. 2000
    Four members of the carcinoembryonic antigen (CEA) family, CEA, CEACAM1 (BGP), CEACAM6 (NCA-50/90), and CEACAM7 (CGM2), are coexpressed in normal colorectal epithelia but are deregulated in colorectal cancers, where they could play a role ..
  46. pmc Clinical value of serum HMGB1 levels in early detection of recurrent squamous cell carcinoma of uterine cervix: comparison with serum SCCA, CYFRA21-1, and CEA levels
    Xiugui Sheng
    Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, People s Republic of China
    Croat Med J 50:455-64. 2009
    ..making the early diagnosis of recurrent cervical squamous cell carcinomas (CSCC) and compare it with the value of serum squamous cell carcinoma antigen (SCCA), cytokeratin fragment (CYFRA) 21-1, and carcinoembryonic antigen (CEA) levels.
  47. ncbi Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level
    In Ja Park
    Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Korea
    Ann Surg Oncol 16:3087-93. 2009
    We evaluated preoperative serum carcinoembryonic antigen (CEA) as a prognostic factor for colorectal cancer and determined when surveillance of this marker was useful.
  48. ncbi The prognostic significance of preoperative serum CA 19-9 in patients with resectable gastric carcinoma: comparison with CEA
    N Duraker
    Third Department of Surgery, SSK Okmeydani Training Hospital, Istanbul, Turkey
    J Surg Oncol 76:266-71. 2001
    In this study, the prognostic value of pre-operative serum levels of tumor markers CA 19-9 and carcinoembryonic antigen (CEA) in gastric carcinoma which has been a controversial matter was investigated.
  49. ncbi Protein epitopes in carcinoembryonic antigen. Report of the ISOBM TD8 workshop
    J Bjerner
    Central Laboratory, Norwegian Radium Hospital, Oslo, Norway
    Tumour Biol 23:249-62. 2002
    To characterize antigenic sites in carcinoembryonic antigen (CEA) further and to investigate whether there are differences between colon tumor CEA and meconium CEA (NCA-2) that can be detected by anti-CEA monoclonal antibodies (MAb), 19 ..
  50. ncbi Serum tumor markers as predictors for survival in advanced non-small cell lung cancer patients treated with gefitinib
    Chao Hua Chiu
    Section of Thoracic Oncology, Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Lung Cancer 57:213-21. 2007
    ..Though the imaging-based response (IBR) is the most frequently used index of the therapeutic effect in cancer patients, an index based on serum tumor markers might prove to be useful, especially in patients without measurable tumors...
  51. ncbi Diagnostic utility of serum and pleural fluid carcinoembryonic antigen, neuron-specific enolase, and cytokeratin 19 fragments in patients with effusions from primary lung cancer
    Jin Hwa Lee
    Department of Internal Medicine, Ewha Womans University, Ewha Medical Research Institute, 911 1 MokDong, Yangcheon Ku, Seoul, South Korea
    Chest 128:2298-303. 2005
    To assess the diagnostic values of carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and cytokeratin 19 fragments (CYFRA 21-1) as markers of pleurisy in primary lung cancer.
  52. ncbi Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1
    Noam Stern
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Immunol 174:6692-701. 2005
    ..Finally, we suggest that the involvement of additional domains beside the N domain in the heterophilic and homophilic interactions is important for regulating the balance between cis and trans interactions...
  53. ncbi Serum CEA as a predictor for the response to preoperative chemoradiation in rectal cancer
    Yoon Ah Park
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    J Surg Oncol 93:145-50. 2006
    ..The aim of this study was to investigate the predictive value of serum carcinoembryonic antigen (CEA) levels for the tumor response to preoperative CRT in rectal cancer patients.
  54. ncbi Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zeta-based chimeric immune receptors
    David E Gilham
    CRC Department of Medical Oncology, Paterson Institute for Cancer Research, University of Manchester, UK
    J Immunother 25:139-51. 2002
    ..Viability was improved by a costimulatory signal indicating that such signals may be vital in the maintenance of long-term functional activity of receptor modified T lymphocytes...
  55. ncbi Successful cancer vaccine therapy for carcinoembryonic antigen (CEA)-expressing colon cancer using genetically modified dendritic cells that express CEA and T helper-type 1 cytokines in CEA transgenic mice
    Toshiyasu Ojima
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    Int J Cancer 120:585-93. 2007
    ..determine whether the vaccination of genetically modified dendritic cells (DCs) simultaneously expressing carcinoembryonic antigen (CEA), granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 12 (IL-12) can overcome ..
  56. pmc Prognostic significance of CTCs and CSCs of tumor drainage vein blood in Dukes' stage B and C colorectal cancer patients
    Ryu Shimada
    Department of Surgery, Teikyo University School of Medicine, Tokyo 173 0003, Japan
    Oncol Rep 27:947-53. 2012
    ..In this study, we investigated the prognostic value of CTC/CSC that express carcinoembryonic antigen (CEA) cytokeratin 19 (CK19), CK20 and/or CD133 (CEA/CK/CD133) mRNA in the tumor drainage ..
  57. pmc Non-redundant role for IL-12 and IL-27 in modulating Th2 polarization of carcinoembryonic antigen specific CD4 T cells from pancreatic cancer patients
    Elena Tassi
    Tumor Immunology Unit, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 4:e7234. 2009
    ..We previously reported that pancreatic cancer patients have a selective Th2 skew in the anti-carcinoembryonic antigen (CEA) CD4(+) T cell immunity, which correlates with the presence of a predominant GATA-3(+) tumor ..
  58. doi Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen
    Rinke Bos
    Department of Immunohematology and Blood Transfusion, Tumor Immunology Group, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 68:8446-55. 2008
    b>Carcinoembryonic antigen (CEA) is intensively studied as a potential target for immunotherapy of colorectal cancers...
  59. pmc Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review
    G Peach
    Division of Surgery, Department of Surgery and Cancer, Faculty of Medicine, St Mary s Campus, Imperial College London, Praed Street, London W2 1NY, UK
    Br J Cancer 102:1327-34. 2010
    ..This systematic review examines evidence for the use of peripherally sampled, circulating tumour cells (CTCs) as such a prognostic marker...
  60. pmc Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer
    Hye Won Chung
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Transl Med 7:38. 2009
    ..We investigated the correlation between the serum HMGB1 levels and the clinical and pathologic features of gastric cancer and evaluated the validity of HMGB1 as a potential biomarker for the early diagnosis of gastric cancer...
  61. doi Early postoperative CEA level is a better prognostic indicator than is preoperative CEA level in predicting prognosis of patients with curable colorectal cancer
    Jen Kou Lin
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, No 201, Section 2, Shih Pai Road Taipei, 11217, Taipei, Taiwan
    Int J Colorectal Dis 26:1135-41. 2011
    b>Carcinoembryonic antigen (CEA) measurements performed preoperatively and during the early postoperative period were examined prospectively to assess their prognostic value for colorectal cancer (CRC) patients receiving curative surgery.
  62. pmc Prediction of survival and recurrence by serum and cytosolic levels of CEA, CA125 and SCC antigens in resectable non-small-cell lung cancer
    M Diez
    San Carlos University Hospital, Madrid, Spain
    Br J Cancer 73:1248-54. 1996
    ..non-small-cell lung cancer patients were analysed with respect of TNM stage, histological type and carcinoembryonic antigen (CEA), CA125 antigen and squamous cell carcinoma antigen (SCC) levels in serum and cytosol...
  63. pmc Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae
    Helen Sarantis
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Infect Immun 80:345-58. 2012
    ..Neisseria interacts with neutrophils through ligation of human carcinoembryonic antigen related-cellular adhesion molecules (CEACAMs) by their surface-expressed Opa proteins, resulting in ..
  64. doi Biomarkers in the lung cancer diagnosis: a clinical perspective
    X Li
    Department of Respiratory Medicine, The First Affiliated Hospital of Xian Jiaotong University, School of Medicine, Xian Jiaotong University, Xian 710061, China
    Neoplasma 59:500-7. 2012
    ..This study aimed to evaluate the efficiency of 7 tumor biomarkers, namely, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 (CYFRA-21-1), alpha-fetoprotein, carbohydrate ..
  65. pmc Multiplexed homogeneous proximity ligation assays for high-throughput protein biomarker research in serological material
    Martin Lundberg
    Olink Bioscience, Dag Hammarskjölds väg 54A, 75183 Uppsala Sweden
    Mol Cell Proteomics 10:M110.004978. 2011
    ..To illustrate the potential of this protein detection technology, a pilot biomarker research project was performed using biobanked plasma samples for the detection of colorectal cancer using a multivariate signature...
  66. pmc Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow
    Susan N Thomas
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 283:15647-55. 2008
    ..Using immunoaffinity chromatography and tandem mass spectrometry, we identify this glycoprotein as the carcinoembryonic antigen (CEA)...
  67. pmc Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells
    Che Ming Jack Hu
    Department of Nanoengineering and Moores Cancer Center, University of California San Diego, La Jolla, California 92093, USA
    Mol Pharm 7:914-20. 2010
    ..Herein, we synthesize anti-carcinoembryonic antigen (CEA) half-antibody conjugated lipid-polymer hybrid nanoparticles and characterize their ligand ..
  68. pmc Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene
    Jessica Nöckel
    Tumor Immunology Laboratory, LIFE Center, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 23, 81377 Munich, Germany
    BMC Cancer 6:57. 2006
    ....
  69. ncbi 124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice
    Gobalakrishnan Sundaresan
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Nucl Med 44:1962-9. 2003
    ..The present work evaluated the minibody or diabody labeled with (124)I, for imaging tumor-bearing mice using a high-resolution small-animal PET system...
  70. ncbi Diagnostic precision of carcinoembryonic antigen in the detection of recurrence of colorectal cancer
    Emile Tan
    Department of Biosurgery and Surgical Technology, Imperial College, 10th Floor, QEQM Wing, Faculty of Medicine, St Mary s Hospital, Praed Street, London W2 1NY, UK
    Surg Oncol 18:15-24. 2009
    The aim of the study was to evaluate the diagnostic precision of serum carcinoembryonic antigen (CEA) in the detection of local or distant recurrence following resectional surgery for colon and rectal cancer.
  71. pmc A recombinant anti-carcinoembryonic antigen immunoreceptor with combined CD3zeta-CD28 signalling targets T cells from colorectal cancer patients against their tumour cells
    A Hombach
    Tumorgenetik, Klinik I fur Innere Medizin, Klinikum der Universität zu Köln, Germany
    Gut 55:1156-64. 2006
    ..The aim of this study was to address whether T cells from colorectal cancer patients with advanced tumour stages can be specifically antigen activated against their autologous tumour cells...
  72. doi Pancreatic cyst aspiration analysis for cystic neoplasms: mucin or carcinoembryonic antigen--which is better?
    Gareth Morris-Stiff
    Department of Hepato pancreato biliary Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Surgery 148:638-44; discussion 644-5. 2010
    ..advocated the performance of endoscopic ultrasound (EUS) with aspiration and determination of mucin and carcinoembryonic antigen (CEA) content...
  73. pmc Persistent high postoperative carcinoembryonic antigen in colorectal cancer patients--is it important?
    Ali Ilker Filiz
    Department of General Surgery, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey
    Clinics (Sao Paulo) 64:287-94. 2009
    ..Evaluation of pre- and postoperative serum CEA levels together has seldom been assessed for the prognosis of colorectal cancer (CRC)...
  74. doi Assessment of tumor recurrence in patients with colorectal cancer and elevated carcinoembryonic antigen level: FDG PET/CT versus contrast-enhanced 64-MDCT of the chest and abdomen
    Ur Metser
    Department of Medical Imaging, Princess Margaret Hospital, University Health Network, 610 University Ave, Ste 3 960, Toronto, ON, M5G 2M9 Canada
    AJR Am J Roentgenol 194:766-71. 2010
    ..of this study was to compare FDG PET/CT and contrast-enhanced 64-MDCT of the chest, abdomen, and pelvis in the detection of tumor recurrence in patients with colorectal cancer and an elevated level of carcinoembryonic antigen (CEA).
  75. ncbi Carcinoembryonic antigen, squamous cell carcinoma antigen, CYFRA 21-1, and neuron-specific enolase in squamous cell lung cancer patients
    Jan Kulpa
    Department of Clinical Biochemistry, Center of Oncology, Cracow Division, 31 115 Cracow, Poland
    Clin Chem 48:1931-7. 2002
    b>Carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC-Ag), and CYFRA 21-1 are the most useful markers for non-small cell lung cancer (NSCLC), but neuron-specific enolase (NSE) is a tumor maker of choice for SCLC...
  76. ncbi The granulocyte receptor carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) directly associates with Vav to promote phagocytosis of human pathogens
    Tim Schmitter
    Zentrum für Infektionsforschung, Universitat Wurzburg, Wurzburg, Germany
    J Immunol 178:3797-805. 2007
    The human granulocyte-specific receptor carcinoembryonic antigen-related cell adhesion molecule (CEACAM)3 is critically involved in the opsonin-independent recognition of several bacterial pathogens...
  77. ncbi Free DNA and carcinoembryonic antigen serum levels: an important combination for diagnosis of colorectal cancer
    Emanuela Flamini
    Department of Medical Oncology, Morgagni Pierantoni Hospital, Forli, Italy
    Clin Cancer Res 12:6985-8. 2006
    ..We compared the sensitivity and specificity of free circulating DNA with that of the more conventional carcinoembryonic antigen (CEA) and evaluated the two markers in combination.
  78. doi Induction of type 1 cytokines during neem leaf glycoprotein assisted carcinoembryonic antigen vaccination is associated with nitric oxide production
    Koustav Sarkar
    Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute CNCI, 37, S P Mukherjee Road, Kolkata 700026, India
    Int Immunopharmacol 9:753-60. 2009
    Involvement of the nitric oxide (NO) release in CEAM phi NLGP (carcinoembryonic antigen pulsed macrophages with neem leaf glycoprotein) vaccination and its relationship with vaccine induced type 1 immune response were aimed to study in ..
  79. pmc Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging
    Vania Kenanova
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, 700 Westwood Plaza, Los Angeles, CA 90095, USA
    Eur J Nucl Med Mol Imaging 36:104-14. 2009
    ..We have developed a reporter gene based on carcinoembryonic antigen (CEA), a human protein with limited normal tissue expression.
  80. ncbi Image-guided radioiodide therapy of medullary thyroid cancer after carcinoembryonic antigen promoter-targeted sodium iodide symporter gene expression
    Christine Spitzweg
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University, 81377 Munich, Germany
    Hum Gene Ther 18:916-24. 2007
    ..therapy of MTC after human sodium iodide symporter (hNIS) gene transfer, using the tumor-specific carcinoembryonic antigen (CEA) promoter for transcriptional targeting...
  81. ncbi The expression of CD66a and possible roles in colorectal adenoma and adenocarcinoma
    Wan Yi Kang
    Department of Pathology, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, Taiwan
    Int J Colorectal Dis 22:869-74. 2007
    ..and possible role of CD66a in colorectal adenoma and adenocarcinoma and the relationship between its expression and pre-operation serum carcinoembryonic antigen (CEA) level and tumor stage in patients with colorectal adenocarcinomas.
  82. pmc Increased serum levels of tumour-associated trypsin inhibitor independently predict a poor prognosis in colorectal cancer patients
    Alexander Gaber
    Department of Laboratory Medicine, Lund University, Skane University Hospital, Center for Molecular Pathology, Malmo, Sweden
    BMC Cancer 10:498. 2010
    ..We further assessed the prognostic value of carcino-embryonic antigen in serum (s-CEA) and the interrelationship between s-TATI and TATI in tissue (t-TATI)...
  83. pmc Quantitative serial imaging of an 124I anti-CEA monoclonal antibody in tumor-bearing mice
    James R Bading
    Department of Radioimmunotherapy, City of Hope, Duarte, CA 91010 3000, USA
    Cancer Biother Radiopharm 23:399-409. 2008
    ..However, high positron energy and beta(+) -associated cascade gamma rays pose image resolution and background noise problems for (124)I. This study evaluated quantitative PET of an (124)I mAb in tumor-bearing mice...
  84. ncbi Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas
    T Kinugasa
    Department of Surgery, School of Medicine, Fukuoka University, Japan
    Int J Cancer 76:148-53. 1998
    Four human carcinoembryonic antigen (CEA) family members, CEA (CD66e), non-specific cross-reacting antigen (NCA, CD66c), biliary glycoprotein (BGP, CD66a) and CEA gene-family member 2 (CGM2), are expressed in normal mucosal epithelia of ..
  85. ncbi Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells
    H Goto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 94:414-9. 2001
    ..antitumor effects together with minimal adverse reactions in specific gene therapy against disseminated carcinoembryonic antigen (CEA)-producing cancer cells in the peritoneal cavity of mice...
  86. ncbi Serum interleukin-6 and -10 levels in patients with gastric cancer
    Masahide Ikeguchi
    Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, 36 1 Nishi cho, Yonago, 683 8504, Japan
    Gastric Cancer 12:95-100. 2009
    ..In the present study, we evaluated the clinical significance of preoperative serum IL-6 and IL-10 levels as new tumor markers in patients with gastric cancer (GC)...
  87. pmc Colorectal hyperplasia and dysplasia due to human carcinoembryonic antigen (CEA) family member expression in transgenic mice
    Carlos H F Chan
    McGill Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 2:e1353. 2007
    ..These results suggest that up-regulated non-mutated adhesion molecules could have a significant instrumental role in human cancer...
  88. ncbi A disposable electrochemical immunosensor for flow injection immunoassay of carcinoembryonic antigen
    Jie Wu
    Key Laboratory of Analytical Chemistry for Life Science Education Ministry of China, Department of Chemistry, Nanjing University, Nanjing 210093, PR China
    Biosens Bioelectron 22:102-8. 2006
    A new simple immunoassay method for carcinoembryonic antigen (CEA) detection using a disposable immunosensor coupled with a flow injection system was developed...
  89. ncbi Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging
    Tove Olafsen
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California at Los Angeles, 90095, USA
    Cancer Res 65:5907-16. 2005
    ..1 +/- 1.5% ID/g). Thus, by manipulating the size and format of anti-p185(HER2) antibody fragments, the kidney activity was reduced and high or low expression of p185HER2 in xenografts could be distinguished by microPET imaging...
  90. pmc In vivo selection for Neisseria gonorrhoeae opacity protein expression in the absence of human carcinoembryonic antigen cell adhesion molecules
    Amy N Simms
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Infect Immun 74:2965-74. 2006
    ..Based on the absence in mice of human carcinoembryonic antigen cell adhesion molecules, the major class of Opa protein adherence receptors, we conclude the observed ..
  91. pmc Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae
    M P Bos
    Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840 2999, USA
    Infect Immun 65:2353-61. 1997
    ..Together these data show that CEA family members are differentially recognized by gonococcal Opa variants, suggesting that this phenomenon may contribute to cell tropism displayed by gonococci...
  92. ncbi The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancer
    X G Ni
    Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Eur J Surg Oncol 31:164-9. 2005
    Serum tumour markers carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and CA242 were investigated to evaluate the values of single and combined test in the diagnosis and prognosis of pancreatic cancer.
  93. ncbi Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae
    James W Booth
    Division of Cell Biology, Hospital for Sick Children, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 278:14037-45. 2003
    ..cells through interactions between bacterial opacity-associated (Opa) adhesins and members of the human carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) family...
  94. pmc Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment
    Li Chu Sun
    Nutrition Service Team, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    BMC Cancer 9:288. 2009
    ..The aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment...
  95. ncbi Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function
    Atsushi Nakajima
    Gastroenterology Division, Departments of Medicine and Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:1028-35. 2002
    ..These studies support a role for CEACAM1 as a novel class of immunoreceptor tyrosine-based inhibition motif-bearing regulatory molecules on T cells that are active during early phases of the immune response in mice...
  96. pmc Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus A59
    Erin Hemmila
    Department of Microbiology, University of Colorado Health Sciences Center, Denver, USA
    J Virol 78:10156-65. 2004
    CEACAM1a glycoproteins are members of the immunoglobulin (Ig) superfamily and the carcinoembryonic antigen family...
  97. ncbi The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma
    Robert Kammerer
    Tumour Immunology Laboratory, Department of Urology, University Clinic Grosshadern, Ludwig Maximilians University Munchen, Munich, Germany
    J Pathol 204:258-67. 2004
    ..Thus, transient expression of the tumour suppressor CEACAM1 by tumour cells and subsequent homophilic interaction with CEACAM1 on tumour-infiltrating lymphocytes could represent a novel immune escape mechanism in RCC...
  98. ncbi CEACAMs: their role in physiology and pathophysiology
    Katharina Kuespert
    Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universitat Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany
    Curr Opin Cell Biol 18:565-71. 2006
    b>Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins...
  99. ncbi A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen
    M A Morse
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 5:1331-8. 1999
    ..with in vitro-generated DCs, loaded with an HLA-A2-restricted peptide fragment of the tumor antigen carcinoembryonic antigen (CEA), for the treatment of patients with advanced CEA-expressing malignancies...
  100. ncbi Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells
    Jana Babatz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Cancer Immunol Immunother 55:268-76. 2006
    ..the capability of DCs differentiated from immunomagnetically isolated CD14+ monocytes and pulsed with a carcinoembryonic antigen-derived altered peptide (CEAalt) to induce specific CD8+ T cells in cancer patients...
  101. ncbi More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells
    Shengming Dai
    Institute of Immunology, Zhejiang University, Hangzhou, People s Republic of China
    Clin Cancer Res 11:7554-63. 2005
    ..To improve the immunogenicity of exosomes as cancer vaccine, we prepared exosomes from heat-stressed carcinoembryonic antigen (CEA)-positive tumor cells (CEA+/HS-Exo) and tested the efficacy of these exosomes in the induction of ..

Research Grants78

  1. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2010
    ..Tumor cells expressing model tumor antigens, such as, ovalbumin (OVA) and carcinoembryonic antigen (CEA) will be used in these studies...
  2. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2009
    ..Tumor cells expressing model tumor antigens, such as, ovalbumin (OVA) and carcinoembryonic antigen (CEA) will be used in these studies...
  3. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2010
    ..Tumor cells expressing model tumor antigens, such as, ovalbumin (OVA) and carcinoembryonic antigen (CEA) will be used in these studies...
  4. Histopathologic and Immunohistochemical Features of Tissue Adherent to the Electr
    Constantinos Sofocleous; Fiscal Year: 2009
    ..ablated tumor (adherent to the electrode and obtained with needle biopsy) with peripheral blood levels of carcinoembryonic antigen (CEA)...
  5. Development of a gold nanoparticles based targeted delivery system
    Priyabrata Mukherjee; Fiscal Year: 2010
    ..all the pancreatic tumor cells or patients that do not express EGFR, we may use other targets such as carcinoembryonic antigen (CEM) or carbohydrate antigen 19-9 (CA-19-9) or need to further identify other targeting molecules and ..
  6. Development of a gold nanoparticles based targeted delivery system
    Priyabrata Mukherjee; Fiscal Year: 2009
    ..all the pancreatic tumor cells or patients that do not express EGFR, we may use other targets such as carcinoembryonic antigen (CEM) or carbohydrate antigen 19-9 (CA-19-9) or need to further identify other targeting molecules and ..
  7. Optimizing Measles Virotherapy in the Treatment of Recurrent Ovarian Cancer
    Evanthia Galanis; Fiscal Year: 2009
    ..to translate this approach into a phase I clinical trial of a measles virus derivative producing human carcinoembryonic antigen, MV-CEA (CEA added to facilitate viral monitoring) in recurrent ovarian cancer patients...
  8. Tumor-specific agents for cancer imaging
    MARIA DA GRACA HENRIQUES VICENTE; Fiscal Year: 2010
    ..Specifically our strategy involves the targeting of epidermal growth factor receptors (EGF-R) and human carcinoembryonic antigen (CEA), both over-expressed in colon cancer cells...
  9. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 2001
    We have generated a murine monoclonal anti-idiotype ( antibody, 3Hl, that is the internal image of the carcinoembryonic antigen (CEA)...
  10. Active Immunotherapy with Pox Vector Modified DC
    Michael Morse; Fiscal Year: 2004
    ..project will test whether dendritic cells (DC) modified with pox vectors encoding the tumor antigen carcinoembryonic antigen (CEA) will induce a clinically-effective frequency of tumor antigen-specific T cells in patients with ..
  11. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 2000
    We have generated a murine monoclonal anti-idiotype ( antibody, 3Hl, that is the internal image of the carcinoembryonic antigen (CEA)...
  12. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 1999
    We have generated a murine monoclonal anti-idiotype ( antibody, 3Hl, that is the internal image of the carcinoembryonic antigen (CEA)...
  13. Optimizing Measles Virotherapy in the Treatment of Ovarian Cancer
    Evanthia Galanis; Fiscal Year: 2009
    ..to translate this approach into a phase I clinical trial of a measles virus derivative producing human carcinoembryonic antigen, MV-CEA (CEA added to facilitate monitoring of viral gene expression) in recurrent ovarian cancer ..
  14. Optimizing Measles Virotherapy in the Treatment of Ovarian Cancer
    Kah Whye Peng; Fiscal Year: 2010
    ..to translate this approach into a phase I clinical trial of a measles virus derivative producing human carcinoembryonic antigen, MV-CEA (CEA added to facilitate monitoring of viral gene expression) in recurrent ovarian cancer ..
  15. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 2002
    We have generated a murine monoclonal anti-idiotype ( antibody, 3Hl, that is the internal image of the carcinoembryonic antigen (CEA)...
  16. COLON CANCER AND ENGINEERED ANTIBODIES
    John Shively; Fiscal Year: 1990
    ..Antibodies to carcinoembryonic antigen will be used throughout this Program because of their specificity for colon cancer...
  17. CARCINOEMBRYONIC ANTIGEN--STRUCTURE-FUNCTION-REGULATION
    John Shively; Fiscal Year: 1992
    b>Carcinoembryonic antigen (CEA) is a highly-glycosylated, colonic epithelial cell surface glycoprotein which is routinely used as a tumor marker for colon cancer...
  18. Mechanisms of Host Responses in Gonorrhea
    Tie Chen; Fiscal Year: 2005
    ..and phagocytosis in epithelial cells and neutrophils in part through interaction with members of the carcinoembryonic antigen family (CEA, CEACAM, or CD66), CEACAM3 (CD66d) and CEACAM1 (CD66a)...
  19. Use of Quantitative RT PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2001
    ..In Specific Aim 1 we will measure mRNA expression levels of molecular markers carcinoembryonic antigen (CEA) and cytokeratin 19(CK19) in LN's from EC and benign disease patients...
  20. Use of Quantitative RT PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2004
    ..In Specific Aim 1 we will measure mRNA expression levels of molecular markers carcinoembryonic antigen (CEA) and cytokeratin 19(CK19) in LN's from EC and benign disease patients...
  21. Use of Quantitative RT PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2003
    ..In Specific Aim 1 we will measure mRNA expression levels of molecular markers carcinoembryonic antigen (CEA) and cytokeratin 19(CK19) in LN's from EC and benign disease patients...
  22. Use of Quantitative RT PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2001
    ..In Specific Aim 1 we will measure mRNA expression levels of molecular markers carcinoembryonic antigen (CEA) and cytokeratin 19(CK19) in LN's from EC and benign disease patients...
  23. Use of Quantitative RT PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2002
    ..In Specific Aim 1 we will measure mRNA expression levels of molecular markers carcinoembryonic antigen (CEA) and cytokeratin 19(CK19) in LN's from EC and benign disease patients...
  24. Use of Quantitative RT PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2003
    ..In Specific Aim 1 we will measure mRNA expression levels of molecular markers carcinoembryonic antigen (CEA) and cytokeratin 19(CK19) in LN's from EC and benign disease patients...
  25. Structure and dynamics of bacterial membrane protein - receptor interactions
    Linda Columbus; Fiscal Year: 2009
    ..The larger class, OpaCEA, bind to carcinoembryonic antigen-like cellular adhesion molecules (CEACAMs), and the smaller class, OpaHS, bind to two different receptors;..
  26. Structure and dynamics of bacterial membrane protein - receptor interactions
    LINDA M COLUMBUS; Fiscal Year: 2010
    ..The larger class, OpaCEA, bind to carcinoembryonic antigen-like cellular adhesion molecules (CEACAMs), and the smaller class, OpaHS, bind to two different receptors;..
  27. Use of Quantitative RT PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2004
    ..In Specific Aim 1 we will measure mRNA expression levels of molecular markers carcinoembryonic antigen (CEA) and cytokeratin 19(CK19) in LN's from EC and benign disease patients...
  28. BIOENGINEERED ANTIBODIES IN CANCER IMAGING AND THERAPY
    Andrew Raubitschek; Fiscal Year: 2000
    ..is to define the clinical role of radiolabeled, genetically engineered antibodies directed against anti-carcinoembryonic antigen (CEA)...
  29. Mechanisms of Host Responses in Gonorrhea
    Tie Chen; Fiscal Year: 2006
    ..and phagocytosis in epithelial cells and neutrophils in part through interaction with members of the carcinoembryonic antigen family (CEA, CEACAM, or CD66), CEACAM3 (CD66d) and CEACAM1 (CD66a)...
  30. Mechanisms of Host Responses in Gonorrhea
    Tie Chen; Fiscal Year: 2004
    ..and phagocytosis in epithelial cells and neutrophils in part through interaction with members of the carcinoembryonic antigen family (CEA, CEACAM, or CD66), CEACAM3 (CD66d) and CEACAM1 (CD66a)...
  31. Cell-type specific targeting of curcumin
    BIDDANDA PONNAPPA; Fiscal Year: 2004
    ..Recent studies show that curcumin has both anti-inflammatory and anti-cancer properties. Carcinoembryonic antigen (CEA), a glycosylated protein secreted by tumor cells, has been implicated in the development of hepatic ..
  32. METABOLISM OF CARCINOEMBRYONAL ANTIGEN
    Peter Thomas; Fiscal Year: 1993
    b>Carcinoembryonic antigen (CEA) can function as both a homotypic and heterotypic cell adhesion molecule...
  33. Cell-type specific targting of curcumin
    BIDDANDA PONNAPPA; Fiscal Year: 2005
    ..Recent studies show that curcumin has both anti-inflammatory and anti-cancer properties. Carcinoembryonic antigen (CEA), a glycosylated protein secreted by tumor cells, has been implicated in the development of hepatic ..
  34. PRE-TARGETED GALLIUM-68 POSITRON EMISSION TOMOGRAPHY
    Gary Griffiths; Fiscal Year: 1999
    ..We will iodine-l25 label an anti-carcinoembryonic antigen complementarity determining region-grafted x murine antidiethylenetriaminepentaacatec acid bispecific F(..
  35. TFF3 GENE EXPRESSION IN METASTATIC COLON CANCER
    Steven Itzkowitz; Fiscal Year: 2001
    ..We have also demonstrated that placing the suicide gene under the control of the carcinoembryonic antigen (CEA) promoter affords greater tissue specificity...
  36. TUMOR VACCINE CATBRM
    Albert LoBuglio; Fiscal Year: 1993
    ..Schlom). The initial protocol involves the use of a recombinant vaccinia-carcinoembryonic antigen (rV-CEA) vaccine to be tested in low tumor burden colon cancer patients...
  37. TFF3 GENE EXPRESSION IN METASTATIC COLON CANCER
    Steven Itzkowitz; Fiscal Year: 1999
    ..We have also demonstrated that placing the suicide gene under the control of the carcinoembryonic antigen (CEA) promoter affords greater tissue specificity...
  38. TFF3 GENE EXPRESSION IN METASTATIC COLON CANCER
    Steven Itzkowitz; Fiscal Year: 2000
    ..We have also demonstrated that placing the suicide gene under the control of the carcinoembryonic antigen (CEA) promoter affords greater tissue specificity...
  39. ENGINEERED ANTIBODIES IN CANCER THERAPY
    John Shively; Fiscal Year: 1993
    ..engineered antibodies in the treatment of human colonic cancer and other solid tumors which produce carcinoembryonic antigen (CEA)...
  40. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
    b>Carcinoembryonic antigen (CEA) is an intercellular adhesion molecule that plays a major role in colon tumorigenesis. We have identified a novel protein on human monocytes that binds to CEA...
  41. RECOMBINANT TUMOR VACCINE--CATBRM
    Albert LoBuglio; Fiscal Year: 1999
    ..The program is currently carrying out a phase Ib trial of recombinant vaccinia-carcinoembryonic antigen (CEA) immunization in resected Dukes' C colorectal cancer patients and a phase I trial of baculovirus ..
  42. TUMOR-SPECIFIC AND TUMOR-ASSOCIATED ANTIGENS
    Felix Milgrom; Fiscal Year: 1980
    Investigation on carcinoembryonic antigen (CEA) will be mostly devoted to immunization of rats with CEA of murine origin...
  43. Rational Design of Therapeutic Vaccines for CEA+ Tumors
    MALAYA CHATTERJEE; Fiscal Year: 2006
    ..suggest that vaccination with an anti-idiotype (Id) antibody (3H1) that mimics an epitope of human carcinoembryonic antigen (CEA) has the potential to augment survival benefits...
  44. Rational Design of Therapeutic Vaccines for CEA+ Tumors
    MALAYA CHATTERJEE; Fiscal Year: 2004
    ..suggest that vaccination with an anti-idiotype (Id) antibody (3H1) that mimics an epitope of human carcinoembryonic antigen (CEA) has the potential to augment survival benefits...
  45. Rational Design of Therapeutic Vaccines for CEA+ Tumors
    MALAYA CHATTERJEE; Fiscal Year: 2005
    ..suggest that vaccination with an anti-idiotype (Id) antibody (3H1) that mimics an epitope of human carcinoembryonic antigen (CEA) has the potential to augment survival benefits...
  46. Rational Design of Therapeutic Vaccines for CEA+ Tumors
    MALAYA CHATTERJEE; Fiscal Year: 2003
    ..suggest that vaccination with an anti-idiotype (Id) antibody (3H1) that mimics an epitope of human carcinoembryonic antigen (CEA) has the potential to augment survival benefits...
  47. Immunotherapy with TRICOM Modified Dendritic Cells
    Herbert Lyerly; Fiscal Year: 2002
    ..we have demonstrated that fowlpox engineered to express B7- 1, ICAM-1 and LFA-3 and the tumor antigen carcinoembryonic antigen (CEA) can infect human DC, express these molecules and stimulate CEA specific T cells in vitro...
  48. SELECTED MARKERS IN NONINVASIVE BLADDER TUMORS
    FRITZ HERZ; Fiscal Year: 1992
    ..The value of additional markers, carcinoembryonic antigen, nuclear proliferation antigen and placental alkaline phosphatase will be explored...
  49. Immunotherapy with TRICOM Modified Dendritic Cells
    Herbert Lyerly; Fiscal Year: 2001
    ..we have demonstrated that fowlpox engineered to express B7- 1, ICAM-1 and LFA-3 and the tumor antigen carcinoembryonic antigen (CEA) can infect human DC, express these molecules and stimulate CEA specific T cells in vitro...
  50. Rational Design of Therapeutic Vaccines for CEA+ Tumors
    SUNIL CHATTERJEE; Fiscal Year: 2007
    ..suggest that vaccination with an anti-idiotype (Id) antibody (3H1) that mimics an epitope of human carcinoembryonic antigen (CEA) has the potential to augment survival benefits...
  51. SECRETORY DIARRHEA: CELLULAR MECHANISMS
    Jonathan Cohn; Fiscal Year: 1990
    ..6/ Develop a brush border membrane preparation procedure for T84 cells using carcinoembryonic antigen as a marker...
  52. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    JOHN JESSUP; Fiscal Year: 2000
    ..b>Carcinoembryonic antigen (CEA), a 180 kDa glycoprotein tumor marker, is associated with liver metastasis because serum levels of ..
  53. ANTIGEN PRESENTATION BY CEA DIRECTED TUMOR VACCINES
    Howard Kaufman; Fiscal Year: 2003
    b>Carcinoembryonic antigen (CEA) is a common tumor-associated antigen. Several T-cell specific epitopes have been identified within the terminal repeat domains of CEA, suggesting that CEA may be a target for vaccine development...
  54. ANTIGEN PRESENTATION BY CEA DIRECTED TUMOR VACCINES
    Howard Kaufman; Fiscal Year: 2001
    b>Carcinoembryonic antigen (CEA) is a common tumor-associated antigen. Several T-cell specific epitopes have been identified within the terminal repeat domains of CEA, suggesting that CEA may be a target for vaccine development...
  55. ANTIGEN PRESENTATION BY CEA DIRECTED TUMOR VACCINES
    Howard Kaufman; Fiscal Year: 2000
    b>Carcinoembryonic antigen (CEA) is a common tumor-associated antigen. Several T-cell specific epitopes have been identified within the terminal repeat domains of CEA, suggesting that CEA may be a target for vaccine development...
  56. SELECTIVE RADIOIMMUNOTHERAPY OF COLON CANCER
    David Goldenberg; Fiscal Year: 1980
    ..design and synthesis of boron-containing compounds capable of labeling immunoglobulins prepared against carcinoembryonic antigen (CEA) with the retention of immunoreactivity...
  57. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    JOHN JESSUP; Fiscal Year: 2001
    ..b>Carcinoembryonic antigen (CEA), a 180 kDa glycoprotein tumor marker, is associated with liver metastasis because serum levels of ..
  58. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    JOHN JESSUP; Fiscal Year: 2004
    ..b>Carcinoembryonic antigen (CEA), a 180 kDa glycoprotein tumor marker, is associated with liver metastasis because serum levels of ..
  59. ANTIGEN PRESENTATION BY CEA DIRECTED TUMOR VACCINES
    Howard Kaufman; Fiscal Year: 2002
    b>Carcinoembryonic antigen (CEA) is a common tumor-associated antigen. Several T-cell specific epitopes have been identified within the terminal repeat domains of CEA, suggesting that CEA may be a target for vaccine development...
  60. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    JOHN JESSUP; Fiscal Year: 2003
    ..b>Carcinoembryonic antigen (CEA), a 180 kDa glycoprotein tumor marker, is associated with liver metastasis because serum levels of ..
  61. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    JOHN JESSUP; Fiscal Year: 2002
    ..b>Carcinoembryonic antigen (CEA), a 180 kDa glycoprotein tumor marker, is associated with liver metastasis because serum levels of ..
  62. CLINICAL RADIOIMMUNODETECTION AND RADIOIMMUNOTHERAPY IN THE MANAGEMENT OF CANCER
    ROBERT SHARKEY; Fiscal Year: 2000
    ..In this new funding period, 3 humanized antibodies (hMAbs) will be used: MN-14 (anti-carcinoembryonic antigen) and Mu-9 (anti-colon-specific antigen- p), both reactive with colorectal and pancreatic cancers, and ..
  63. CLINICAL RADIOIMMUNODETECTION AND RADIOIMMUNOTHERAPY IN THE MANAGEMENT OF CANCER
    ROBERT SHARKEY; Fiscal Year: 1999
    ..In this new funding period, 3 humanized antibodies (hMAbs) will be used: MN-14 (anti-carcinoembryonic antigen) and Mu-9 (anti-colon-specific antigen- p), both reactive with colorectal and pancreatic cancers, and ..
  64. Y 90 CHIMERIC T84 66 ANTI CEA ANTIBODY G CSF, STEM CELL SUPPORT IN BREAST CANCER
    Jeffrey Wong; Fiscal Year: 2000
    ..evaluate the biodistribution, tumor targeting properties and pharmacokinetics of a radiolabeled anti-CEA (Carcinoembryonic Antigen) antibody for therapy; To begin to evaluate its anti-tumor effects and to determine the highest, safest ..
  65. Molecular Detection of Occult Metastases in Lung Cancer
    Tony Godfrey; Fiscal Year: 2002
    ..Thus, in Specific Aims 1 and 2 of this proposal, we will use QRT-PCR for carcinoembryonic antigen (CEA) and cytokeratin 19 (CK 19) to detect micrometastases in the lymph nodes, blood and bone marrow of ..
  66. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    Lopa Mishra; Fiscal Year: 2007
    ..produced by the host liver as arresting tumor cells create an ischemia/reperfusion injury, 2) CRC release Carcinoembryonic Antigen (CEA), a 180 kDa glycoprotein, that binds to heterogeneous RNA-binding protein M4 on Kupffer cells (the ..
  67. BIOENGINEERED ANTIBODIES IN CANCER IMAGING AND THERAPY
    Andrew Raubitschek; Fiscal Year: 1999
    ..is to define the clinical role of radiolabeled, genetically engineered antibodies directed against anti-carcinoembryonic antigen (CEA)...
  68. RADIOIMMUNOTHERAPY OF ADVANCED REFRACTORY OVARIAN CANCER
    Malik Juweid; Fiscal Year: 1999
    ..EOC is known to produce carcinoembryonic antigen (CEA)...
  69. BIOENGINEERED ANTIBODIES IN CANCER IMAGING AND THERAPY
    Andrew Raubitschek; Fiscal Year: 2001
    ..is to define the clinical role of radiolabeled, genetically engineered antibodies directed against anti-carcinoembryonic antigen (CEA)...
  70. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    Lopa Mishra; Fiscal Year: 2010
    ..produced by the host liver as arresting tumor cells create an ischemia/reperfusioninjury, 2) CRC release Carcinoembryonic Antigen (CEA), a 180 kDa glycoprotein, that binds to heterogeneous RNA-binding protein M4 on Kupffer cells (the ..
  71. Y 90 CHIMERIC T84 66 ANTI CEA ANTIBODY IN ADVANCE CEA PRODUCING MALIG
    Jeffrey Wong; Fiscal Year: 2000
    ..Physician Eligibility Summary: Histological diagnosis of cancer with CEA (Carcinoembryonic Antigen) producing tumors; Cancer of which the majority is confined to the peritoneal cavity and unresponsive to ..
  72. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    Lopa Mishra; Fiscal Year: 2009
    ..produced by the host liver as arresting tumor cells create an ischemia/reperfusioninjury, 2) CRC release Carcinoembryonic Antigen (CEA), a 180 kDa glycoprotein, that binds to heterogeneous RNA-binding protein M4 on Kupffer cells (the ..
  73. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    Lopa Mishra; Fiscal Year: 2006
    ..produced by the host liver as arresting tumor cells create an ischemia/reperfusion injury, 2) CRC release Carcinoembryonic Antigen (CEA), a 180 kDa glycoprotein, that binds to heterogeneous RNA-binding protein M4 on Kupffer cells (the ..