biological markers


Summary: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Top Publications

  1. ncbi Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell 131:861-72. 2007
  2. doi Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
    Xi Chen
    Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China
    Cell Res 18:997-1006. 2008
  3. ncbi Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 145:247-54. 2006
  4. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
  5. pmc Serum microRNAs are promising novel biomarkers
    Shlomit Gilad
    Rosetta Genomics Ltd, Rehovot, Israel
    PLoS ONE 3:e3148. 2008
  6. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
  7. ncbi Inflammation and atherosclerosis
    Peter Libby
    Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 105:1135-43. 2002
  8. pmc Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 7:280-92. 2011
  9. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
  10. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008

Detail Information

Publications360 found, 100 shown here

  1. ncbi Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    Kazutoshi Takahashi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell 131:861-72. 2007
    ..Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts...
  2. doi Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
    Xi Chen
    Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China
    Cell Res 18:997-1006. 2008
    ..Through these analyses, we conclude that serum miRNAs can serve as potential biomarkers for the detection of various cancers and other diseases...
  3. ncbi Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 145:247-54. 2006
    ..The 4-variable equation from the Modification of Diet in Renal Disease (MDRD) Study has been reexpressed for use with a standardized assay...
  4. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
    ..The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers...
  5. pmc Serum microRNAs are promising novel biomarkers
    Shlomit Gilad
    Rosetta Genomics Ltd, Rehovot, Israel
    PLoS ONE 3:e3148. 2008
    ..Here we show that microRNAs, a family of small non-coding regulatory RNAs involved in human development and pathology, are present in bodily fluids and represent new effective biomarkers...
  6. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues...
  7. ncbi Inflammation and atherosclerosis
    Peter Libby
    Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 105:1135-43. 2002
  8. pmc Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 7:280-92. 2011
  9. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..The existence of these cells opens new opportunities for myocardial repair...
  10. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
    ..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown...
  11. pmc Circulating microRNAs, potential biomarkers for drug-induced liver injury
    Kai Wang
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 106:4402-7. 2009
    ..These findings suggest the potential of using specific circulating microRNAs as sensitive and informative biomarkers for drug-induced liver injury...
  12. doi In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    Qiao Zhou
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 455:627-32. 2008
    ..This study provides an example of cellular reprogramming using defined factors in an adult organ and suggests a general paradigm for directing cell reprogramming without reversion to a pluripotent stem cell state...
  13. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
    ..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
  14. pmc Identification and proteomic profiling of exosomes in human urine
    Trairak Pisitkun
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 101:13368-73. 2004
    ..The results indicate that exosome isolation may provide an efficient first step in biomarker discovery in urine...
  15. pmc Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
    Michael J Pencina
    Department of Biostatistics, Boston University, 801 Massachusetts Ave, Boston, MA 02118, USA
    Stat Med 30:11-21. 2011
    ..We recommend that researchers clearly define and justify the choices they make when choosing NRI for their application...
  16. pmc Plasma levels of soluble CD14 independently predict mortality in HIV infection
    Netanya G Sandler
    Human Immunology Section, Vaccine Research Center
    J Infect Dis 203:780-90. 2011
    ..The association of microbial translocation with clinical outcome remains unknown...
  17. doi α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study
    Brit Mollenhauer
    Paracelsus Elena Klinik, Kassel, Germany
    Lancet Neurol 10:230-40. 2011
    ..We aimed to assess whether reduction of α-synuclein concentrations in CSF was a marker for α-synuclein deposition in the brain, and therefore diagnostic of synucleinopathies...
  18. pmc Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)
    Evan M Kroh
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Methods 50:298-301. 2010
    ..We describe here our procedure for qRT-PCR analysis of circulating miRNAs as biomarkers, and discuss relevant issues of sample preparation, experimental design and data analysis...
  19. pmc ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    Christophe Ginestier
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 1:555-67. 2007
    ..These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts...
  20. ncbi Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78228 3900, USA
    Circulation 102:42-7. 2000
    ..Recently, some components of the insulin resistance syndrome (IRS) have been related to inflammatory markers. We hypothesized that insulin insensitivity, as directly measured, may be associated with inflammation in nondiabetic subjects...
  21. pmc Metabolite profiles and the risk of developing diabetes
    Thomas J Wang
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:448-53. 2011
    ..These findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment...
  22. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
    ..We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for ischaemic renal injury after cardiopulmonary bypass...
  23. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
    ..Negation of ras-induced senescence may be relevant during multistep tumorigenesis...
  24. ncbi The immune response in atherosclerosis: a double-edged sword
    Goran K Hansson
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, SE 17176, Sweden
    Nat Rev Immunol 6:508-19. 2006
    ..We also outline possible future targets for prevention, diagnosis and treatment of atherosclerosis...
  25. pmc The microRNA spectrum in 12 body fluids
    Jessica A Weber
    Institute for Systems Biology, 1441 North 34th St, Seattle, WA 98103, USA
    Clin Chem 56:1733-41. 2010
    ..Extracellular miRNAs in serum, plasma, saliva, and urine have recently been shown to be associated with various pathological conditions including cancer...
  26. pmc The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Marilyn S Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 7:270-9. 2011
    ..Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings...
  27. doi Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
  28. pmc MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
    Kasey C Vickers
    National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr Building 10 8N222, Bethesda, Maryland 20892, USA
    Nat Cell Biol 13:423-33. 2011
    ..Collectively, these observations indicate that HDL participates in a mechanism of intercellular communication involving the transport and delivery of miRNAs...
  29. pmc Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
    Clifford R Jack
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA jack cliff
    Lancet Neurol 9:119-28. 2010
  30. ncbi Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005
    ..The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic value associated with circulating endothelial progenitor cells has not been defined...
  31. doi Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis
    Michael Haase
    Department of Nephrology and Intensive Care Medicine, Charite University Medicine, Berlin, Germany
    Am J Kidney Dis 54:1012-24. 2009
    ..Neutrophil gelatinase-associated lipocalin (NGAL) appears to be a promising biomarker for the early diagnosis of acute kidney injury (AKI); however, a wide range in its predictive value has been reported...
  32. doi Outcomes for COPD pharmacological trials: from lung function to biomarkers
    M Cazzola
    Unit of Respiratory Diseases, Dept of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur Respir J 31:416-69. 2008
    ..Based on their review of the published literature, the following document has been prepared with individual sections that address specific outcomes and markers, and a final section that summarises their recommendations...
  33. pmc Estimating glomerular filtration rate from serum creatinine and cystatin C
    Lesley A Inker
    Division of Nephrology, Tufts Medical Center, 800 Washington St, Box 391, Boston, MA 02111, USA
    N Engl J Med 367:20-9. 2012
    ..Cystatin C is an alternative filtration marker for estimating GFR...
  34. ncbi The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    S Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 7:1028-34. 2001
    ..These results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources...
  35. ncbi How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
    ..The updated strategies for the diagnosis and exclusion of HFNEF are useful not only for individual patient management but also for patient recruitment in future clinical trials exploring therapies for HFNEF...
  36. doi Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Prog Lipid Res 47:348-80. 2008
    ..The relationship between plasma lipoprotein concentrations and total plasma fatty acid composition, and the use of fatty acid ratios as indices of enzyme activity are also addressed...
  37. doi Circulating microRNAs: biomarkers or mediators of cardiovascular diseases?
    Stephan Fichtlscherer
    Division of Cardiology, Department of Medicine III, Goethe University, Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 31:2383-90. 2011
    ..In addition, the mechanisms by which miRs are released and their putative function as long-distance communicators are discussed...
  38. doi Detection and characterization of placental microRNAs in maternal plasma
    Stephen S C Chim
    Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Clin Chem 54:482-90. 2008
    ..Because nucleic acids of placental origin are released into maternal plasma, we hypothesized that miRNAs produced by the placenta would also be released into maternal plasma...
  39. ncbi Milestones of neuronal development in the adult hippocampus
    Gerd Kempermann
    VolkswagenStiftung Research Group, Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Trends Neurosci 27:447-52. 2004
    ..The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development...
  40. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  41. pmc Clinical and biomarker changes in dominantly inherited Alzheimer's disease
    Randall J Bateman
    Washington University School of Medicine, Department of Neurology, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    N Engl J Med 367:795-804. 2012
    ..Autosomal dominant Alzheimer's disease has a predictable age at onset and provides an opportunity to determine the sequence and magnitude of pathologic changes that culminate in symptomatic disease...
  42. ncbi The clinical implications of endothelial dysfunction
    Michael E Widlansky
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 42:1149-60. 2003
    ..This article will review this growing literature in an effort to evaluate the current clinical utility of endothelial dysfunction...
  43. ncbi Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
    ..Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), may have a pathogenic role...
  44. pmc Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
    Leslie M Shaw
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 65:403-13. 2009
    ..Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects...
  45. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  46. ncbi A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
    Vanda A Lennon
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Lancet 364:2106-12. 2004
    ..We assessed the capacity of a putative marker for neuromyelitis optica (NMO-IgG) to distinguish neuromyelitis optica and related disorders from multiple sclerosis...
  47. doi Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction
    Jing Ai
    The Department of Pharmacology, Harbin Medical University, Harbin 150081, PR China
    Biochem Biophys Res Commun 391:73-7. 2010
    ..8522 for separation AMI patients under hospitalization and discharge. Collectively, our results revealed that circulating miR-1 may be a novel, independent biomarker for diagnosis of AMI...
  48. ncbi Neuronal replacement from endogenous precursors in the adult brain after stroke
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Nat Med 8:963-70. 2002
    ..If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans...
  49. ncbi Treatment of periodontitis and endothelial function
    Maurizio S Tonetti
    Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, USA
    N Engl J Med 356:911-20. 2007
    ..Systemic inflammation may impair vascular function, and epidemiologic data suggest a possible link between periodontitis and cardiovascular disease...
  50. ncbi Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Kidney Dis 40:221-6. 2002
    ..However, there are conflicting reports regarding the superiority of Cys C over serum creatinine (Cr), with a few studies suggesting no significant difference...
  51. pmc Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, 1120 NW 14th St, Miami, FL 33136, USA
    JAMA 305:2432-9. 2011
  52. ncbi AC133, a novel marker for human hematopoietic stem and progenitor cells
    A H Yin
    AmCell Corp, Sunnyvale, CA 94089, USA
    Blood 90:5002-12. 1997
  53. ncbi Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, C H U Bordeaux, Pessac, France
    Gastroenterology 128:343-50. 2005
  54. doi Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, SE 431 80 Molndal, Sweden
    Nat Rev Neurol 6:131-44. 2010
    ..Furthermore, we outline the roles of CSF biomarkers in drug discovery and clinical trials, and provide perspectives on AD biomarker discovery and the validation of such markers for use in the clinic...
  55. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Aarhus C, Denmark
    Eur Heart J 28:2525-38. 2007
  56. pmc Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, 98104, USA
    Ann Neurol 69:570-80. 2011
    ..We and others have demonstrated that a decrease in DJ-1 and/or α-synuclein in the cerebrospinal fluid (CSF) is a potential index for Parkinson disease diagnosis, but not for PD severity...
  57. pmc Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Kidney Int 79:1370-8. 2011
    ..Hence, FGF23 measurements may be a sensitive early biomarker of disordered phosphorus metabolism in patients with CKD and normal serum phosphate levels...
  58. doi Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases
    Yi Zhang
    Department of Medical Genetics, Second Military Medical University, Shanghai, China
    Clin Chem 56:1830-8. 2010
    ..Recently, circulating microRNAs (miRNAs) have been reported as potential biomarkers for the noninvasive diagnosis of cancer. In this study, we investigated whether plasma miRNAs have diagnostic utility in identifying liver disease...
  59. ncbi Clinical application of C-reactive protein for cardiovascular disease detection and prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 107:363-9. 2003
  60. ncbi Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    Karl Ludwig Laugwitz
    Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 433:647-53. 2005
    ..The discovery of native cardioblasts represents a genetically based system to identify steps in cardiac cell lineage formation and maturation in development and disease...
  61. ncbi In vitro hepatic differentiation of human mesenchymal stem cells
    Kuan Der Lee
    Division of Cancer Research, National Health Research Institutes, Taiwan
    Hepatology 40:1275-84. 2004
    ..Furthermore, the broad differentiation potential of MSCs indicates that a revision of the definition may be required...
  62. pmc Ink4a/Arf expression is a biomarker of aging
    Janakiraman Krishnamurthy
    Department of Medicine, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599 7295, USA
    J Clin Invest 114:1299-307. 2004
    ..These data suggest that expression of the Ink4a/Arf tumor suppressor locus is a robust biomarker, and possible effector, of mammalian aging...
  63. pmc Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    Zeneng Wang
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Nature 472:57-63. 2011
  64. doi Current status of cadmium as an environmental health problem
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Toxicol Appl Pharmacol 238:201-8. 2009
    ..Therefore, measures should be put in place to reduce exposure to a minimum, and the tolerably daily intake should be set in accordance with recent findings...
  65. doi Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis
    Suetonia C Palmer
    Department of Medicine, University of Otago, Christchurch, New Zealand
    JAMA 305:1119-27. 2011
    ..Clinical practice guidelines on the management of mineral and bone disorders due to chronic kidney disease recommend specific treatment target levels for serum phosphorus, parathyroid hormone, and calcium...
  66. doi Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort
    N S M Schoonenboom
    Departments of Neurology, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Neurology 78:47-54. 2012
    ..To determine how amyloid β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) levels in CSF behave in a large cohort of patients with different types of dementia...
  67. ncbi Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association
    Thomas A Pearson
    Circulation 107:499-511. 2003
  68. doi CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    JAMA 302:385-93. 2009
  69. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabak
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
    ..We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individuals who develop type 2 diabetes...
  70. pmc Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
    Lewis H Kuller
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS Med 5:e203. 2008
    ..We hypothesized that increased HIV-RNA levels following ART interruption induced activation of tissue factor pathways, thrombosis, and fibrinolysis...
  71. pmc DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    Zhen Hong
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
    Brain 133:713-26. 2010
    ..We have demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration...
  72. pmc Circulating microRNAs are new and sensitive biomarkers of myocardial infarction
    Yuri D'Alessandra
    Laboratorio di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milan, Italy
    Eur Heart J 31:2765-73. 2010
    ..Circulating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice...
  73. doi Biomarkers in chronic kidney disease: a review
    Robert G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Kidney Int 80:806-21. 2011
    ..Although none are ready for use in clinical practice, it is timely to review the role of such biomarkers in predicting CKD progression and/or CVD risk in CKD...
  74. pmc Impact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus
    Wen Sheng Yue
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 10:113. 2011
    ..Levels of circulating endothelial progenitor cells (EPCs) are also reduced in hyperglycemic states. However, the relationships between glycemic control, levels of EPCs and arterial stiffness are unknown...
  75. pmc FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis
    Jessica Kendrick
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA
    J Am Soc Nephrol 22:1913-22. 2011
    ..In conclusion, in advanced CKD, FGF-23 strongly and independently associates with all-cause mortality, cardiovascular events, and initiation of chronic dialysis...
  76. doi Immunological biomarkers of tuberculosis
    Gerhard Walzl
    Immunology Research Group, NRF DST Centre of Excellence for TB Biomedical Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, South Africa
    Nat Rev Immunol 11:343-54. 2011
    ..Here, we review immunological markers, their relation to M. tuberculosis infection stages and their potential use in the fight against tuberculosis...
  77. doi Changes in forced expiratory volume in 1 second over time in COPD
    Jørgen Vestbo
    Respiratory Section, Hvidovre Hospital, Hvidovre, Denmark
    N Engl J Med 365:1184-92. 2011
  78. pmc Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    Nita G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 57:2619-25. 2008
    ..However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study...
  79. pmc Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management
    Raj Vuppalanchi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hepatology 49:306-17. 2009
    ..Several recent studies have highlighted that cardiovascular disease is the single most important cause of morbidity and mortality in this patient population...
  80. pmc Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:192-200. 2005
    ..This approach allows the urinary analyte concentration to be appropriately adjusted for urinary creatinine and the statistical significance of other variables in the model to be independent of effects of creatinine concentration...
  81. ncbi Endothelial function and dysfunction: testing and clinical relevance
    John E Deanfield
    Vascular Physiology Unit, UCL Institute of Child Health, London, UK
    Circulation 115:1285-95. 2007
  82. ncbi Germline stem cells and follicular renewal in the postnatal mammalian ovary
    Joshua Johnson
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:145-50. 2004
    ..Collectively, these data establish the existence of proliferative germ cells that sustain oocyte and follicle production in the postnatal mammalian ovary...
  83. doi Exosomes: proteomic insights and diagnostic potential
    Richard J Simpson
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Expert Rev Proteomics 6:267-83. 2009
    ..New advances in proteomic methods, and both mass spectrometry hardware and informatics tools will be covered briefly...
  84. ncbi Biomarkers of oxidative damage in human disease
    Isabella Dalle-Donne
    Department of Biology, University of Milan, Milan, Italy
    Clin Chem 52:601-23. 2006
    ..Here we discuss some of the more commonly used biomarkers of oxidative/nitrosative damage and include selected examples of human studies...
  85. pmc Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection
    Jacqueline Neuhaus
    University of Minnesota, Minneapolis, Minnesota 55414, USA
    J Infect Dis 201:1788-95. 2010
    ..Human immunodeficiency virus (HIV) replication and immune activation may increase inflammation and coagulation biomarkers. Limited data exist comparing such biomarkers in persons with and without HIV infection...
  86. pmc Arterial stiffness and cardiovascular events: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    Circulation 121:505-11. 2010
    ..Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffness measures to prognosis in the community...
  87. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
  88. ncbi Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
    Olaf Beckonert
    Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, UK
    Nat Protoc 2:2692-703. 2007
  89. ncbi Cellular senescence in aging primates
    Utz Herbig
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA
    Science 311:1257. 2006
    ..In addition, the same cells contain activated ataxia-telangiectasia mutated kinase and heterochromatinized nuclei, confirming their senescent status...
  90. pmc Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
    Alvar Agusti
    Thorax Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona and Centro de investigación en red de enfermedades respiratorias CIBERES, Barcelona, Spain
    PLoS ONE 7:e37483. 2012
    ..To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552)...
  91. ncbi Plasma adiponectin levels and risk of myocardial infarction in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Channing Laboratory, Boston, Mass 02115, USA
    JAMA 291:1730-7. 2004
    ..Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in the development of atherosclerosis and coronary heart disease in humans...
  92. doi Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma
    Li Min Li
    Institute for Virology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
    Cancer Res 70:9798-807. 2010
    ..96 (specificity: 96%; sensitivity: 100%) in HCC prediction. In conclusion, our study demonstrates for the first time that serum miRNA profiles can serve as novel and noninvasive biomarkers for HBV infection and HBV-positive HCC diagnosis...
  93. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Gade 2, DK 8000 Aarhus C, Denmark
    J Am Coll Cardiol 50:2173-95. 2007
  94. doi Prospective study on circulating MicroRNAs and risk of myocardial infarction
    Anna Zampetaki
    King s British Heart Foundation Centre, King s College London, United Kingdom
    J Am Coll Cardiol 60:290-9. 2012
    ..This study sought to explore the association between baseline levels of microRNAs (miRNAs) (1995) and incident myocardial infarction (1995 to 2005) in the Bruneck cohort and determine their cellular origin...
  95. doi Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage
    Yasuhide Kuwabara
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circ Cardiovasc Genet 4:446-54. 2011
    ..The purpose of this study was to identify the source of elevated levels of circulating miRNAs and their function in cardiovascular diseases...
  96. doi Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet
    Iris Shai
    S Daniel Abraham Center for Health and Nutrition, Ben Gurion University of the Negev, Beer Sheva, Israel
    N Engl J Med 359:229-41. 2008
    ..Trials comparing the effectiveness and safety of weight-loss diets are frequently limited by short follow-up times and high dropout rates...
  97. ncbi Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial
    Ramon Estruch
    Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
    Ann Intern Med 145:1-11. 2006
    ..The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors...
  98. ncbi Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    Circulation 107:1514-9. 2003
    ..Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular disease 2- to 3-fold. The factors responsible for this association remain largely unknown...
  99. doi Revising the definition of Alzheimer's disease: a new lexicon
    Bruno Dubois
    Pierre and Marie Curie University, Research Centre of the Institute of the Brain and Spinal Cord, UMR, AP HP, Pitié Salpêtrière Hospital Group, Paris, France
    Lancet Neurol 9:1118-27. 2010
    ..The cornerstone of this lexicon is to consider AD solely as a clinical and symptomatic entity that encompasses both predementia and dementia phases...
  100. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
    ..As a general mechanism, this change in fate highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions...
  101. pmc Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction
    Guangwen Long
    Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Biol Sci 8:811-8. 2012
    ..A remarkable finding in this study is that miR-1, miR-126 and cTnI expression levels exhibited the same trend. Our results suggest that the plasma concentrations of miR-1 and miR-126 may be useful indicators for AMI...

Research Grants80

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..Before we can properly design prevention trials with the right intervention, the right target population and the right endpoints, we need preliminary studies for guidance, such as we have proposed. ..
  3. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..Understanding more precisely the characteristics of and the mechanism(s) behind desensitization will enable physicians to better utilize this approach to reduce mast cell/basophil-mediated contributions to asthma and allergic diseases. ..
  4. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: It would be desirable to develop a test that will identify the biological markers of Alzheimer's disease, much like cholesterol now serving as a biomarker of heart disease...
  5. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    ..many factors have been implicated in the initiation and continued usage of menthol cigarettes, studies of biological markers of smoking demonstrate that menthol itself inhibits nicotine metabolism, and that menthol cigarette smoking ..
  6. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..This proposal meets the goals of the US Public Health Service in treating chronic liver diseases. ..
  7. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..The proposed in vivo studies are expected to provide insights into the adverse and beneficial effects of HIF-1[unreadable] and NO in SCD, which may lead to new therapeutic strategies. ..
  8. Role of the insulin/IGF-axis in incident CIN-2+
    Howard D Strickler; Fiscal Year: 2010
  9. Hypoplastic Left Heart Syndrome: Expression of RHD in the Fetus?
    Pirooz Eghtesady; Fiscal Year: 2013
    ..Tremendous resources are devoted to its medical management. Therefore, understanding why HLHS happens, the goal of the proposed research would have great significance and relevance to public health. ..
  10. Daily Experience in Adolescence and Biomarkers of Early Risk for Adult Health
    Andrew J Fuligni; Fiscal Year: 2013
    ..The project will include both intensive behavioral assessments and detailed biological markers of health risk from both adolescents and their parents in order to address the following specific aims: (1) ..
  11. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic 03-DK-101: "Discovery of biomarkers for disease risk, progression or response to therapy in diseases of interest to NINDK" ..
  12. Inhibiting EGFR and ER pathways in NSCLC
    Edward B Garon; Fiscal Year: 2013
    ..At the conclusion of this research training, I will be well positioned to function as an independent physician scientist in patient-oriented lung cancer research, and I anticipate competing for independent research funding. ..
  13. Validation and Quantification of FFPE Antigen Retrieval by Proteome Analysis
    XUPEING FANG; Fiscal Year: 2010
    ..cells from high quality specimens reside in the identification of diagnostic, prognostic, and predictive biological markers in the clinical setting and during preclinical testing and clinical trials, as well as the discovery and ..
  14. Molecular Determinants Affecting FLT-PET in Colorectal Cancer
    HENRY C MANNING; Fiscal Year: 2010
  15. A Cohort Study of Preterm Delivery in Relation to Partner Abuse, Mood and Anxiety
    Michelle A Williams; Fiscal Year: 2013
    ..We will evaluate the extent to which risk of PTD is influenced by alternations in multiple biological markers of maternal neuroendocrine, vascular, and immune status...
  16. Plasma iNOS IVD Prognosticates Sepsis Prior to Organ Damage and Dysfunction
    Robert J Webber; Fiscal Year: 2010
  17. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Sherry Chow; Fiscal Year: 2010
    ..This study will help evaluate the potentials of developing limonene as a breast cancer preventive agent. ..
  18. CYP19A1 gene and Pharmacogenetics of Response
    REINA C VILLAREAL; Fiscal Year: 2013
    ..abstract_text> ..
  19. Identification of an Epigenetic Risk Marker for PTSD
    Rachel Yehuda; Fiscal Year: 2010
    ..e., pretraumatic) biologic marker that can ultimately be used in screening persons at increased risk for PTSD either before or immediately after they are exposed to trauma. ..
  20. Role of phosphatidylethanolamine in regulating virulence in Candida albicans
    SARAH ELIZABETH DAVIS; Fiscal Year: 2013
    ..Rim101 pathway), 2) Determine if PS and PE play a role in evading the immune response 3) Discover if auxotrophy for ethanolamine, a known substrate of PE, affects virulence of the mutants in the host. ..
  21. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..Conclusions: This R21 is the essential step to advance the study of EMP as the novel marker of rejection in renal transplant patients. ..
  22. Biological Pathways of Acute and Chronic Stress in Aged Hip Fracture Caregivers
    Lisa Fredman; Fiscal Year: 2012
    ..At each interview, blood pressure, anthropomorphic measures, and biological markers will be obtained (24-hour urine for catecholamines and cortisol, serum for DHEAS, pro- and anti-inflammatory ..
    JUDITH SMITH MERCER; Fiscal Year: 2012
    ..If delaying cord clamping at the births of preterm infants lowers rates of intraventricular hemorrhage and late onset sepsis it may have a dramatic effect on the health and well being of these infants. ..
  24. Regulation of Bone Mineralization in Renal Osteodystrophy
    ISIDRO BENJAMIN SALUSKY; Fiscal Year: 2012
    ..Current evidence indicates that severe bone disease and growth retardation are the main long-term consequences of chronic kidney disease since childhood. ..
  25. Socioeconomic status and smoking exposure in Appalachia
    Joshua E Muscat; Fiscal Year: 2013 determine the relationship between SES and the dose of inhaled mainstream smoke and the dose of biological markers of tobacco smoke exposure. Specific aims are: Specific Aim 1...
  26. Phenotypic Spectrum of LRRK2 Mutations
    Rachel Saunders-Pullman; Fiscal Year: 2013
    ..This study capitalizes on an existing precious cohort of LRRK2 PD, other PD and family members in order to better learn about these features. ..
  27. Cognitive Complaints and Decline and B-Amyloid Deposition in Non-Demented Elderly
    BETH ELLEN SNITZ; Fiscal Year: 2013
    ..Furthermore, complaints have been associated with biological markers of AD, such as brain atrophy, reduced brain metabolism, and AD neuropathology on autopsy...
  28. 1st Tier Drugs+Theophylline in Pediatric Severe Asthma
    JERRY JOHN ZIMMERMAN; Fiscal Year: 2010
    Lisa M Shin; Fiscal Year: 2012
    ..Abnormalities that are found to be acquired could become the target of PTSD treatments, whereas abnormalities that serve as risk factors for PTSD could be used in screening for persons at risk and possible preventive interventions. ..
  30. Biological Markers of Aflatoxin Exposure and Methylation
    Regina M Santella; Fiscal Year: 2013
    ..The development of screening methods for the early detection of disease in high risk populations will lead to better treatment and survival. ..
  31. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..with altered motility, secretion, and visceral sensation within the intestine for which there is no specific biological markers. We will investigate the role of the serotonin signaling system to determine how it functions within the ..
  32. Identification of Mammalian Genes Promoting Life Extension
    SIU HUNG CHICK; Fiscal Year: 2013
    ..We anticipate that the insights gained from these studies will foster a variety of new directions for aging research. ..
  33. Using Genetics For Early Phenotyping &Prevention of Hypertrophic Cardiomyopathy
    Christine E Seidman; Fiscal Year: 2013
    ..Early treatment can be targeted to at-risk, genetically susceptible individuals to offset the consequences of pathogenic mutations and prevent disease progression. ..
  34. Surrogate endpoints for correlating protective immunity in response to influenza
    Gary Fujii; Fiscal Year: 2010
  35. A Genetic Model for Understanding the Metabolic Syndrome/Obesity Relationship
    ..These findings will help evaluate the viability of pharmacological MC3-R manipulation as a treatment to decrease obesity associated complications. ..
  36. A Prospective Cohort Study of Migraines, Platelet Activation, and Preeclampsia
    Michelle A Williams; Fiscal Year: 2012
    ..and medications used to treat migraines are independently associated with preeclampsia risk;and (3) whether biological markers of platelet aggregation and activation in early pregnancy, are associated with maternal migraine status and ..
  37. Novel High Affinity VEGF Analogs For Targeted Imaging of Thyroid Cancer
    BRUCE DALE WEINTRAUB; Fiscal Year: 2013
  38. Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis
    Jayant A Talwalkar; Fiscal Year: 2010
    ..The proposed research has relevance to public health, because the fundamental mechanisms being investigated appear common for maintaining health and creating disease in human beings. ..
  39. Pharmaconutrients as Therapies for Critical Illness: Zinc in Severe Sepsis
    Renee D Stapleton; Fiscal Year: 2013
    ..Stapleton to gain outstanding experience in pharmacokinetics, dose-finding studies, and translational research in critically ill patients with sepsis. ..
  40. Biomarkers of Exposure to and Health Effects from SHS in Outdoor Smoking Areas
    Luke P Naeher; Fiscal Year: 2011
    ..5 and CO monitors, time-integrated passive area nicotine monitors, as well as biological markers, salivary cotinine and urinary NNAL...
  41. Vaginal microbiota, immune responses and vulvovaginal symptoms during menopause
    Rebecca M Brotman; Fiscal Year: 2013
    ..These data will be used to evaluate the potential for non-hormonal, anti-inflammatory, or probiotic interventions for the treatment of common vulvovaginal complaints in peri- and postmenopausal women. ..
  42. MR Spectroscopy to Evaluate Liver Repopulation by Transplanted Hepatocytes
    Chandan Guha; Fiscal Year: 2009
    ..In this proposal we propose to develop a non -invasive MR Spectroscopic Imaging (MRSI) for the detection of transplanted hepatocytes expressing brain isozyme of cratine kinase (CK-B) as a transgene reporter. ..
  43. The Charge Study: Childhood Autism Risks from Genetics and the Environment
    Irva Hertz-Picciotto; Fiscal Year: 2013
    ..Results of this detailed inquir into early exposures, maternal pathophysiology and prognostic markers in the newborn will set the stage for developing prevention strategies. ..
  44. Chicago Prevention and Intervention Epicenter (Chicago PIE)
    ROBERT ALAN WEINSTEIN; Fiscal Year: 2013
    ..The impact on ICU infection and prescribing characteristics of doctors will be assessed. To further assess the interventions, costs of averted outcomes and of the interventions will be compared. OPRIONAL OBEJCTIVE SCORE: 2 ..
  45. Meditation and Exercise for Prevention of Acute Respiratory Infection
    Bruce P Barrett; Fiscal Year: 2010
    ..Finally, we want to investigate the influence of stress, optimism, anxiety and positive and negative emotion on immunity and resistance to respiratory infection. ..
  46. Glucose Regulation and Memory in Alzheimer's Disease
    Suzanne Craft; Fiscal Year: 2013
    ..Identification of a clear metabolic risk profile in middle age may offer an opportunity for preventative strategies. The proposed study will address one such strategy;consumption of a low saturated fat/low glycemic index diet...
  47. SPORE in Pancreatic Cancer
    James Abbruzzese; Fiscal Year: 2009
    ..To address this issue in patients, a clinical trial entitled "Assessment of Biological Markers of Response to Treatment with Celecoxib and OSl 774 in Patients with Advanced Pancreatic Cancer" is proposed...
  48. Role of Genes in Exceptional Longevity in Humans
    NIR J BARZILAI; Fiscal Year: 2012
    ..families with exceptional longevity (survival in good health to at least age 95) and have identified several biological markers that may be causative in their longevity...
  49. Alum-absorbed subunit vaccine to prevent intestinal amebiasis
    David M Lyerly; Fiscal Year: 2012
  50. Early effects of PTH on the proximal femur
    Felicia Cosman; Fiscal Year: 2013
    ..We will evaluate hip bone samples from patients treated with teriparatide before undergoing hip replacement. The information will help us understand how teriparatide might help reduce hip fracture risk. ..
  51. Suicide Endophenotypes and Molecular Mechanisms of Lithium Action
    Todd D Gould; Fiscal Year: 2013
    ..may modify impulsive and aggressive behavior as well identify points of interaction between lithium and biological markers known to be associated with suicide...
  52. Agonistic Stress and CVD Risk in Young Adults
    Craig K Ewart; Fiscal Year: 2010
    ..g., due to impaired parasympathetic control), and thus will guide practical public health efforts to reduce CVD risk in minority youth and young adults. ..
  53. Inhibition of platelet-leukocyte interactions to treat TRALI
    Paul S Frenette; Fiscal Year: 2010
    ..In this proposal, we will perform translational studies and develop new tools in preparation of a clinical trial to treat and/or prevent TRALI. ..
  54. Role of Paxillin in Lung Cancer
    Ravi Salgia; Fiscal Year: 2012
    ..and mutations of paxillin in NSCLC and correlate with demographic and clinical factors, pertinent biological markers (such as c-Met) and patient survival;2...
  55. Efficacy of Resistance Training as an Aid To Smoking Cessation Treatment
    Joseph T Ciccolo; Fiscal Year: 2013
    ..abstinence self-efficacy, sleep) assessed during the 12-week intervention;(b) treatment differences on biological markers of disease risk (e.g...
  56. Stress, Cellular Aging and Susceptibility to Infectious Disease
    Sheldon A Cohen; Fiscal Year: 2010
    ..or not telomerase activity and oxidative stress constitute pathways through which psychological, social and biological markers of stress might influence telomere length...
  57. Primary Immune Deficiency Treatment Consortium Annual Scientific Meeting
    Luigi Daniele Notarangelo; Fiscal Year: 2013
    ..and analysis in other forms of severe PIDs that can be treated by HCT 3) To analyze the relevance of biological markers that can predict successful immune reconstitution following HCT 4) To discuss the results of novel ..
  58. Neuroendocrine and Neuroimaging Endophenotypes in Postpartum Depression
    ..translate findings to develop methods to identify pregnant women at highest risk of developing PPD based on biological markers and develop gender-specific treatments targeted to underlying pathophysiology in women at high-risk of ..
  59. Correlative Studies for NCI Study#7916: Phase I Clinical Trial of Intravenous FAU
    Patricia Mucci LoRusso; Fiscal Year: 2010
    ..If successful, the proposed experiments may point the way to assays that identify patients who are more or less likely to respond to this therapy, thereby permitting individualized therapy of patients in the future. ..
  60. Impact of Vaccination against GM2, GD2 and GD3 on Disease Free Survival in Resect
    Wolfgang W Scholz; Fiscal Year: 2012
    ..The primary endpoint for this pivotal multicenter randomized trial is improvement in progression-free survival at one year. ..
  61. Signaling Sphingolipids in COPD
    Irina Petrache; Fiscal Year: 2009
    ..This work may contribute to the discovery of targets for therapy in emphysema and to the development of biological markers for this disease.
  62. Immunological Factors and Risk of Vulvodynia
    Bernard L Harlow; Fiscal Year: 2013
    ..sample of women at risk ofVVD (who mayor may not have sought care for their condition), while also measuring biological markers and related psychological processes that inform the plausibility of potential etiological pathways...
  63. Risk of Leukemia after Protracted Exposures to Low Doses of Ionizing Radiation
    ..effects of radiation exposure at low doses as well as to compare the quality and durability of various biological markers of radiation exposure...
  64. Predicting toxicity and success of anti-GD2 immunotherapy of neuroblastoma
    Alice L Yu; Fiscal Year: 2013
    ..18 therapy. Thus, there is a pressing need for the identification of new biological markers that can refine outcome prediction and decrease toxicities without loss of efficacy, which is the focus of ..
  65. Selection and Characterization of PSMA Ligands from Phage-Displayed Libraries
    Gary Fujii; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  66. Using fMRI to Measure Negative Symptoms in Schizophrenia
    EDWARD E contact SMITH; Fiscal Year: 2010 less fMRI activity during the anticipatory-interval but not during the reactive-interval, we will have biological markers for another negative symptom, affective flattening, or reduced reactivity to emotional states be they ..
  67. Phase 2 Pharmacodynamic Study of High-dose Levofloxacin in MDR-TB Treatment
    C Robert Horsburgh; Fiscal Year: 2010
    ..The patients will receive their usual treatment, plus the normal dose of levofloxacin or a higher dose. The study will be performed in the Philippines, where multi-drug-resistant TB is common. ..
  68. Longitudinal Studies of Primary Biliary Cirrhosis
    MARLYN MAYO; Fiscal Year: 2006
    ..In addition, the correlation between each of the putative surrogate markers will be analyzed. The results of this analysis will then be used to design future clinical trials in the field of PBC. [unreadable] [unreadable]..
    Steven Telian; Fiscal Year: 1993
    ..Once isolated we will characterize the effects of our novel mutations and in the long term, clone the genes responsible to study their molecular functions...
  70. Tools for Measuring and Analyzing Cortisol Levels in Population Studies of Health
    Ana V Diez Roux; Fiscal Year: 2010
    ..challenges in studying the role of psychosocial stress include the (1) measurement and characterization of biological markers of the stress response (2) examining how this complex biological response varies as a function of higher-..
    Kiminobu Sugaya; Fiscal Year: 1999
    ..process and to seek the relationship of mitochondrial DNA (mtDNA) damage to cognitive impairment and other biological markers in aged rodent models...
    Laurence Greenhill; Fiscal Year: 2000
    Susan Iannaccone; Fiscal Year: 2005
    ..The second goal is to correlate biological markers with clinical phenotype, clinical outcome measures and response to therapy...
  74. Measurement of CCR5 and CCL3L1 on Single Cell by Fluorescent Metal Nanoparticle
    Richard Yuqi Zhao; Fiscal Year: 2010
    Emil Paganini; Fiscal Year: 2001
    ..It is expected that this project, along with the other IRPG generated data, will provide the building blocks for the design and implementation of future multi-centered interventional trials in Acute Renal Failure.] ..
  76. Potential Surrogate Marker of Epileptogenic Cortex
    Joyce Wu; Fiscal Year: 2009
    K Ang; Fiscal Year: 2002
    ..Further, improvement in therapy outcome would result from identification of biological markers that can predict the probabilities would respond to different therapy modalities...
  78. Multi-Antigen Vaccines for Breast Cancer
    MARY DISIS; Fiscal Year: 2007
    ..abstract_text> ..
    Andrew Olshan; Fiscal Year: 2002
    ..This study will provide important new advances in our understanding of Wilms tumor given the study size, quality of exposure assessment, and incorporation of clinical and biological markers of etiologic heterogeneity.
  80. CSF Indicators for Diagnosis and Disease Progression of ALS
    Carol Milligan; Fiscal Year: 2009
    ..This would help direct future research to identify effective therapeutic approaches. ..