viral hemagglutinins

Summary

Top Publications

  1. ncbi The influenza C virus glycoprotein (HE) exhibits receptor-binding (hemagglutinin) and receptor-destroying (esterase) activities
    R Vlasak
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029
    Virology 160:419-25. 1987
  2. ncbi Mapping the antigenic and genetic evolution of influenza virus
    Derek J Smith
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Science 305:371-6. 2004
  3. ncbi Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins
    Stella Chun
    Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, Ontario, Canada
    Vaccine 26:6068-76. 2008
  4. pmc Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates
    Y P Lin
    Division of Virology, National Institute for Medical Research, Mill Hill, London, United Kingdom Dise
    Proc Natl Acad Sci U S A 97:9654-8. 2000
  5. ncbi Resistant influenza A viruses in children treated with oseltamivir: descriptive study
    Maki Kiso
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Lancet 364:759-65. 2004
  6. ncbi Type A influenza virus surveillance in free-flying, nonmigratory ducks residing on the eastern shore of Maryland
    R D Slemons
    Department of Veterinary Preventive Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA
    Avian Dis 47:1107-10. 2003
  7. pmc 9-O-acetylated sialic acids have widespread but selective expression: analysis using a chimeric dual-function probe derived from influenza C hemagglutinin-esterase
    A Klein
    Glycobiology Program, Cancer Center, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 91:7782-6. 1994
  8. pmc Bilayer conformation of fusion peptide of influenza virus hemagglutinin: a molecular dynamics simulation study
    Qiang Huang
    Department of Chemistry, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
    Biophys J 87:14-22. 2004
  9. ncbi Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection
    M Gocník
    Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic
    J Gen Virol 88:951-5. 2007
  10. ncbi Molecular dynamics simulations of the influenza hemagglutinin fusion peptide in micelles and bilayers: conformational analysis of peptide and lipids
    Patrick Lagüe
    Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    J Mol Biol 354:1129-41. 2005

Research Grants

  1. Enhancing Collectin Mediated Defense Against Influenza
    Kevan L Hartshorn; Fiscal Year: 2013
  2. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
  3. Retrocyclins: Cyclic mini-defensins that inactivate anthrax toxins
    ROBERT IRVING contact LEHRER; Fiscal Year: 2010
  4. M2 peptide based vaccines against influenza
    Andrew Pekosz; Fiscal Year: 2008
  5. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2007
  6. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2007
  7. Structure/biology of short-lived MHC II-ligand complexes
    Scheherazade Sadegh Nasseri; Fiscal Year: 2007
  8. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
  9. Macromolecular X-ray Structure Facility Instrumentation
    Andrew Mesecar; Fiscal Year: 2003
  10. A Molecular Basis for Phytoestrogen Chemoprevention
    Andrew Mesecar; Fiscal Year: 2002

Detail Information

Publications193 found, 100 shown here

  1. ncbi The influenza C virus glycoprotein (HE) exhibits receptor-binding (hemagglutinin) and receptor-destroying (esterase) activities
    R Vlasak
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029
    Virology 160:419-25. 1987
    ..In analogy to the parainfluenza virus HN protein, the influenza C virus glycoprotein was termed HE, because it possesses hemagglutinin and esterase (receptor-destroying) activity...
  2. ncbi Mapping the antigenic and genetic evolution of influenza virus
    Derek J Smith
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Science 305:371-6. 2004
    ..Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution...
  3. ncbi Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins
    Stella Chun
    Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, Ontario, Canada
    Vaccine 26:6068-76. 2008
    ..remarkable specificity against the viral sequences and robustness of quantitatively analyzing the viral hemagglutinins even under stringent conditions...
  4. pmc Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates
    Y P Lin
    Division of Virology, National Institute for Medical Research, Mill Hill, London, United Kingdom Dise
    Proc Natl Acad Sci U S A 97:9654-8. 2000
    ..This common feature emphasizes the apparent propensity of avian viruses with this genetic complement to infect humans and highlights the potential for the emergence of a novel human pathogen...
  5. ncbi Resistant influenza A viruses in children treated with oseltamivir: descriptive study
    Maki Kiso
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Lancet 364:759-65. 2004
    ..Our aim was to investigate oseltamivir resistance in a group of children treated for influenza...
  6. ncbi Type A influenza virus surveillance in free-flying, nonmigratory ducks residing on the eastern shore of Maryland
    R D Slemons
    Department of Veterinary Preventive Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA
    Avian Dis 47:1107-10. 2003
    ....
  7. pmc 9-O-acetylated sialic acids have widespread but selective expression: analysis using a chimeric dual-function probe derived from influenza C hemagglutinin-esterase
    A Klein
    Glycobiology Program, Cancer Center, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 91:7782-6. 1994
    ..Thus, 9-O-acetylation is more widespread than previously thought and occurs on specific molecules and cell types...
  8. pmc Bilayer conformation of fusion peptide of influenza virus hemagglutinin: a molecular dynamics simulation study
    Qiang Huang
    Department of Chemistry, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
    Biophys J 87:14-22. 2004
    ..The average hydrophobic thickness of the lipid phase close to the N-terminus is reduced in comparison with the average hydrophobic thickness of a pure dimyristoyl phosphatidylcholine bilayer...
  9. ncbi Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection
    M Gocník
    Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic
    J Gen Virol 88:951-5. 2007
    ..It is concluded that antibodies specific to the antigenically conserved HA2 glycopolypeptide that exhibit fusion-inhibition activity can contribute to the protection of infected mice and mediate more effective recovery from infection...
  10. ncbi Molecular dynamics simulations of the influenza hemagglutinin fusion peptide in micelles and bilayers: conformational analysis of peptide and lipids
    Patrick Lagüe
    Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    J Mol Biol 354:1129-41. 2005
    ..An extension of the classical surfactant theory of Israelachvili based on shapes is proposed to introduce the concept of a "dynamically induced shape" of the membrane lipids by the peptide...
  11. pmc Plasticity of influenza haemagglutinin fusion peptides and their interaction with lipid bilayers
    Loredana Vaccaro
    National Institute for Medical Research, London, United Kingdom
    Biophys J 88:25-36. 2005
    ..These results confirm that the sequence can adopt different folds in different environments. The plasticity and the conformational dependence on the local environment could be used to better understand the function of fusion peptides...
  12. ncbi Measles virus strains circulating in Central and West Africa: Geographical distribution of two B3 genotypes
    D Waku Kouomou
    INSERM U404, CERVI, Lyon Cedex, France
    J Med Virol 68:433-40. 2002
    ..2 genotype is found in West Africa. In Nigeria and Ghana, the viruses co-circulate. The identification of these viruses will permit more meaningful epidemiological studies after the proposed increase in measles vaccination coverage...
  13. ncbi Genetic characterization of wild-type measles viruses circulating in suburban Khartoum, 1997-2000
    H S El Mubarak
    Institute of Virology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Gen Virol 83:1437-43. 2002
    ..Our study demonstrates a remarkable genetic stability of an endemically circulating MV strain...
  14. ncbi Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype
    G Winter
    Nature 292:72-5. 1981
  15. ncbi Glycan analysis in cell culture-based influenza vaccine production: influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin
    Jana Schwarzer
    Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, 39106 Magdeburg, Germany
    Vaccine 27:4325-36. 2009
    ..In contrast to this, a principal switch of the N-glycan type attached to HA was observed when comparing different virus types (A and B) and subtypes (H1N1 and H3N2)...
  16. ncbi Receptor-binding properties of modern human influenza viruses primarily isolated in Vero and MDCK cells and chicken embryonated eggs
    Larisa Mochalova
    Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho Maklaya 16 10, 117997 Moscow, Russia
    Virology 313:473-80. 2003
    ..These HA mutations disturb the observed strict 6'SLN specificity of recent human influenza viruses...
  17. ncbi Phylogenetic and restriction fragment length polymorphism analyses of hemagglutinin (H) protein of canine distemper virus isolates from domestic dogs in Japan
    Masashi Uema
    Laboratory of Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai Minato ku, Tokyo 108 8639, Japan
    Virus Res 109:59-63. 2005
    ..Thus, the RFLP method is useful for differentiating the infections with field CDV strains from the vaccine strains in clinical cases...
  18. pmc Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses
    Aleksandr S Lipatov
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, Georgia, United States of America
    PLoS Pathog 4:e1000102. 2008
    ....
  19. ncbi Genetic characterization of contemporary wild-type measles viruses from Vietnam and the People's Republic of China: identification of two genotypes within clade H
    S L Liffick
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, 30333, Atlanta, GA, USA
    Virus Res 77:81-7. 2001
    ..Sequence analysis of measles viruses imported into the United States from either China or Vietnam demonstrated that this designation of genotypes will be helpful in future measles surveillance activities...
  20. ncbi Comparative analyses of canine distemper viral isolates from clinical cases of canine distemper in vaccinated dogs
    N T Lan
    Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889 2192, Japan
    Vet Microbiol 115:32-42. 2006
    ..These results surely indicate that wild strains of CDV from dogs with a vaccination history were not reversed vaccine virus, and that the dogs showed characteristics of recent CD in Japan...
  21. pmc Interspecies and intraspecies transmission of triple reassortant H3N2 influenza A viruses
    Hadi M Yassine
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA
    Virol J 4:129. 2007
    ..Identifying viruses with varying inter- and intra-species transmission potential should be useful for further studies on the molecular basis of interspecies transmission...
  22. ncbi Pathobiology of H5N2 Mexican avian influenza virus infections of chickens
    D E Swayne
    US Department of Agriculture, Southeast Poultry Research Laboratory, Athens, GA, USA
    Vet Pathol 34:557-67. 1997
    ....
  23. ncbi Origin of the pandemic 1957 H2 influenza A virus and the persistence of its possible progenitors in the avian reservoir
    J R Schafer
    St Jude Children s Research Hospital, Department of Virology Molecular Biology, Memphis, Tennessee 38105
    Virology 194:781-8. 1993
    ..We conclude that antigenically conserved counterparts of the human Asian pandemic strain of 1957 continue to circulate in the avian reservoir and are coming into closer proximity to susceptible human populations...
  24. pmc Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells
    Fumio Seki
    Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    J Virol 77:9943-50. 2003
    ..Our results indicate that Vero cells stably expressing canine SLAM are highly sensitive to CDV in clinical specimens and that only a single amino acid substitution in the hemagglutinin can allow the virus to adapt to marmoset SLAM...
  25. ncbi Receptor-binding properties of swine influenza viruses isolated and propagated in MDCK cells
    Alexandra S Gambaryan
    Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, 142782 Moscow, Russia
    Virus Res 114:15-22. 2005
    ....
  26. ncbi Genetic analysis of measles viruses isolated in Morocco
    Amal Alla
    Institute of Health, Rabat, Morocco
    J Med Virol 68:441-4. 2002
    ..Knowledge of the indigenous strain of measles virus circulating in Morocco will help to describe viral transmission pathways and should contribute to efforts to evaluate the effectiveness of future vaccination campaigns...
  27. ncbi Sequence analysis of measles virus strains collected during the pre- and early-vaccination era in Denmark reveals a considerable diversity of ancient strains
    L Siig Christensen
    Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
    APMIS 110:113-22. 2002
    ....
  28. ncbi Neutralizing B cell response in measles
    Fabienne B Bouche
    Department of Immunology and WHO Collaborating Center for Measles, Laboratoire National de Santé, Luxembourg, Luxembourg
    Viral Immunol 15:451-71. 2002
    ..Major neutralizing epitopes have been mapped mainly on the hemagglutinin protein with monoclonal antibodies, producing an increasingly comprehensive map of functional domains...
  29. pmc Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine
    Diane E Webster
    Department of Medicine, Monash University Medical School, Alfred Hospital, Prahran, Victoria 3181, Australia
    J Virol 76:7910-2. 2002
    ..This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology...
  30. ncbi H1 genotype of measles virus was detected in outbreaks in Japan after 2000
    Jianhui Zhou
    Laboratory of Viral Infection, Kitasato Institute for Life Sciences, Tokyo, Japan
    J Med Virol 70:642-8. 2003
    ..However, some D3 and H1 strains were not completely neutralized with low levels of neutralizing antibody, and maintaining high levels of measles antibodies would be required for the control measles outbreaks...
  31. ncbi Polarized glycoprotein targeting affects the spread of measles virus in vitro and in vivo
    Markus Moll
    Institute of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
    J Gen Virol 85:1019-27. 2004
    ..These data strongly suggest that basolateral targeting of MV glycoproteins helps to overcome the epithelial barrier and thereby facilitates the systemic spread of MV infection in vivo...
  32. ncbi Large-scale preparation of biologically active measles virus haemagglutinin expressed by attenuated vaccinia virus vectors
    Minoru Kidokoro
    Department of Research and Development, Chiba Serum Institute, 2 6 1 Kohnodai, Ichikawa, Chiba 272 0827, Japan
    Microbes Infect 4:1035-44. 2002
    ..Such recombinant haemagglutinin preparations will be useful in diagnostic tests that measure functional anti-measles immunity and investigate the biological functions and structure of the haemagglutinin...
  33. ncbi The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD150)
    K Tanaka
    Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Arch Virol 147:195-203. 2002
    ..Thus, the measles virus hemagglutinin can induce downregulation of SLAM in cells either expressing or coming in contact with it...
  34. pmc Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution
    Qinghong Zeng
    Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Sciences, Utrecht University, 3584 CL, Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 105:9065-9. 2008
    ..Our findings offer unique insights into the structural and functional consequences of independent protein evolution after interviral gene exchange and open potential avenues to broad-spectrum antiviral drug design...
  35. ncbi Surveillance of avian and swine influenza in the swine population in Taiwan, 2004
    Happy K Shieh
    Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    J Microbiol Immunol Infect 41:231-42. 2008
    ....
  36. ncbi Multiple genotypes of nonpathogenic H6N2 influenza viruses isolated from chickens in California
    R J Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Avian Dis 47:905-10. 2003
    ..Analysis of the remaining gene segments of the California viruses revealed that three distinct genotypes of H6N2 viruses were present...
  37. ncbi Baculovirus display of fusion protein of Peste des petits ruminants virus and hemagglutination protein of Rinderpest virus and immunogenicity of the displayed proteins in mouse model
    Md Masmudur Rahman
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    Virology 317:36-49. 2003
    ..The antigenic epitopes of the recombinant proteins were properly displayed and the recombinant virus particles induced immune response in mice against PPRV or RPV...
  38. ncbi Successful mucosal immunization of cotton rats in the presence of measles virus-specific antibodies depends on degree of attenuation of vaccine vector and virus dose
    Bernd Schlereth
    Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str 7, 97078 Wuerzburg, Germany
    J Gen Virol 84:2145-51. 2003
    ..This study demonstrates that a lower degree of attenuation is required to be able to immunize in the presence of MV-specific antibodies...
  39. ncbi Effective primary isolation of wild-type canine distemper virus in MDCK, MV1 Lu and Vero cells without nucleotide sequence changes within the entire haemagglutinin protein gene and in subgenomic sections of the fusion and phospho protein genes
    John A Lednicky
    Department of Pathology, Loyola University Medical Center, 2160 South First Street, Maywood, IL 60153, USA
    J Virol Methods 118:147-57. 2004
    ..Different viral phenotypes and genotypes were detected. The conservation of H gene sequences in primary CDV isolates suggests that MDCK, MV1 Lu, and Vero cells express proper receptors for wild-type CDV...
  40. ncbi [Influenza viruses which preconditioned the epidemic rise in Russia in 2002-2003. A resumed circulation of influenza viruses similar to V/Victoria/2/87]
    V T Ivanova
    Vopr Virusol 49:12-7. 2004
    ..A study of paired sera obtained from patients showed a growth of antibodies to the etalons of influenza A(H1N1), A(H3N2) and B viruses of the season in question, which confirmed the virology data...
  41. ncbi Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA and M2 proteins
    George P Leser
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
    Virology 342:215-27. 2005
    ..Quantification of the distribution of surface expressed HA by examining serial sections of virus-infected cells suggests that the HA-containing microdomains give rise to regions of influenza assembly and budding...
  42. ncbi Development of quantitative gene-specific real-time RT-PCR assays for the detection of measles virus in clinical specimens
    Kimberly B Hummel
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, 1600 Clifton Road, Mailstop C 22, Atlanta, GA 30333, USA
    J Virol Methods 132:166-73. 2006
    ....
  43. pmc Expression of hemagglutinin esterase protein from recombinant mouse hepatitis virus enhances neurovirulence
    Lubna Kazi
    Department of Microbiology, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 79:15064-73. 2005
    ....
  44. pmc New measles genotype, Uganda
    Apollo Muwonge
    Uganda Virus Research Institute, Entebbe, Uganda
    Emerg Infect Dis 11:1522-6. 2005
    ..Therefore, Ugandan viruses should be considered a new, proposed genotype (d10). This new sequence information will expand the utility of molecular epidemiologic techniques for describing measles transmission patterns in eastern Africa...
  45. ncbi Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes
    Nicole Runkler
    Institute of Virology, Philipps University Marburg, Hans Meerwein Str 2, D 35043 Marburg, Germany
    J Gen Virol 89:687-96. 2008
    ....
  46. ncbi The cowpox virus fusion regulator proteins SPI-3 and hemagglutinin interact in infected and uninfected cells
    Peter C Turner
    Department of Molecular Genetics and Microbiology, Box 100266 1600 SW Archer Road, ARB R2 231, University of Florida, Gainesville, FL 32610 0266, USA
    Virology 347:88-99. 2006
    ..The HA-binding domain in SPI-3 resided in the C-terminal 229 residues, and did not include helix D, which mediates cofactor interaction in many other serpins...
  47. ncbi Identification of trypsin I as a candidate for influenza A virus and Sendai virus envelope glycoprotein processing protease in rat brain
    Trong Quang Le
    Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima 770 8503, Japan
    Biol Chem 387:467-75. 2006
    ..Our results suggest that trypsin I in the brain potentiates virus multiplication in the pathogenesis and progression of influenza-associated encephalopathy or encephalitis...
  48. pmc Immunoglobulin g antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response
    Ianko D Iankov
    Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA
    J Virol 80:8530-40. 2006
    ..The findings point to a new model for the pathogenesis of atypical MV infection observed after immunization with formalin-inactivated MV vaccine and underscore the importance of the anti-F response after vaccination...
  49. ncbi Autocatalytic activation of influenza hemagglutinin
    Jeong H Lee
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 220 South 33rd Street, Philadelphia, PA 19104, USA
    J Mol Biol 364:275-82. 2006
    ..These observations imply a feedback mechanism involving self-catalyzed refolding of HA and thus suggest a mechanism similar to the autocatalytic refolding and aggregation of prions...
  50. pmc Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain
    Emmie de Wit
    Department of Virology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 79:12401-7. 2005
    ..The data presented suggest that vaccine candidates based on low-pathogenicity avian influenza A viruses, which can be prepared ahead of pandemic threats, can be efficacious if an effective adjuvant is used...
  51. pmc Paramyxoviruses: different receptors - different mechanisms of fusion
    Ronald M Iorio
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Trends Microbiol 16:135-7. 2008
    ....
  52. pmc Use of Vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virus
    Chien Hsiung Pan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Clin Vaccine Immunol 15:1214-21. 2008
    ..The use of Vaxfectin-formulated DNA is a promising approach to the development of a measles vaccine for young infants...
  53. ncbi Neuraminidase activity assays for monitoring MDCK cell culture derived influenza virus
    Deba Prasad Nayak
    Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstreet 1, D 39106 Magdeburg, Germany
    J Virol Methods 122:9-15. 2004
    ..Based on the hemagglutinin and neuraminidase activity of the clarified and inactivated virus harvest, the overall recovery after gel filtration was about 34.4% and 119.5%, respectively...
  54. ncbi Genetic characterization of H1N1, H1N2 and H3N2 swine influenza virus in Thailand
    Salin Chutinimitkul
    Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Arch Virol 153:1049-56. 2008
    ..Furthermore, amino acid substitutions were detected either at the receptor binding site or the antigenic sites of the hemagglutinin gene...
  55. ncbi Virus-like particle (VLP) vaccine conferred complete protection against a lethal influenza virus challenge
    Jose M Galarza
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Viral Immunol 18:244-51. 2005
    ....
  56. pmc A seven-segmented influenza A virus expressing the influenza C virus glycoprotein HEF
    Qinshan Gao
    Department of Microbiology, Mount Sinai School of Medicine, Box 1124, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 82:6419-26. 2008
    ..These results support a selective mechanism of viral RNA recruitment to the budding site...
  57. pmc Infectivity studies of influenza virus hemagglutinin receptor binding site mutants in mice
    Jeffrey Meisner
    Emory University School of Medicine, Atlanta, GA 30322, USA
    J Virol 82:5079-83. 2008
    ..The capacity of the Y98F mutant to induce antibody responses and the structural locations of HA reversion mutations are examined...
  58. pmc Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles
    Chien Hsiung Pan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:11581-8. 2005
    ..Viremia was cleared within 14 days, but MV RNA was detectable for 4-5 months. These studies suggest that complete clearance of MV after infection is a prolonged, phased, and complex process influenced by prior vaccination...
  59. ncbi Interactions among measles virus hemagglutinin, fusion protein and cell receptor signaling lymphocyte activation molecule (SLAM) indicating a new fusion-trimer model
    Peng Zhang
    National Key Lab of Virology, College of Life Scince, Wuhan University, Hu Bei, Wuhan 430072, P R China
    J Biochem Mol Biol 38:373-80. 2005
    ..So fusion protein not only is involved in the fusion but also might directly interact with the SLAM to be a new fusion-trimer model, which might account for the infection mechanism of measles virus...
  60. pmc Relative contributions of measles virus hemagglutinin- and fusion protein-specific serum antibodies to virus neutralization
    Rik L De Swart
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Virol 79:11547-51. 2005
    ..These results demonstrate that measles virus neutralizing antibodies are mainly directed to the H protein...
  61. ncbi Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination
    Martin O Ota
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Infect Dis 195:1799-807. 2007
    ..No single peptide dominated the response. We conclude that H is an important stimulus for CD8+ T cell as well as for antibody responses in HLA-A2-positive individuals...
  62. pmc Efficiency of measles virus entry and dissemination through different receptors
    Urs Schneider
    Molecular Medicine Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Virol 76:7460-7. 2002
    ..To verify the importance of these observations for human infections, we examined MV entry into peripheral blood mononuclear cells and observed that viruses with asparagine 481 H proteins infect these cells more efficiently...
  63. ncbi Measles virus exploits dendritic cells to suppress CD4+ T-cell proliferation via expression of surface viral glycoproteins independently of T-cell trans-infection
    B Dubois
    , IFR 74, CERVI, , Lyon, France
    Cell Immunol 214:173-83. 2001
    ....
  64. ncbi Sequence analysis of hemagglutinin and nucleoprotein genes of measles viruses isolated in Korea during the 2000 epidemic
    B K Na
    Department of Virology, National Institute of Health, 122-701, Seoul, South Korea
    Virus Res 81:143-9. 2001
    ..4% for the H protein and up to 6.5% for the N protein. Phylogenetic analyses of nucleotide sequences and deduced amino acid sequences of the H and N genes revealed that all Korean viruses were grouped into the clade H1...
  65. pmc Adaptation of wild-type measles virus to tissue culture
    Diane Waku Kouomou
    INSERM U 404, CERVI, 69365 Lyon Cedex 07, France
    J Virol 76:1505-9. 2002
    ..The presence of human SLAM expressed in the Vero cells rapidly gave rise to fusion and lower yields of infectious virus...
  66. ncbi C3d enhancement of neutralizing antibodies to measles hemagglutinin
    T D Green
    Department of Microbiology and Immunology, School of Medicine, East Carolina University, Brody Health Sciences Building, 600 Moye Boulevard, Greenville, NC 27858-4354, USA
    Vaccine 20:242-8. 2001
    ..In addition, sH-3C3d elicited higher neutralizing antibody titers that inhibited MV induced plaque formation...
  67. pmc Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles
    M J Schnell
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 93:11359-65. 1996
    ..Recombinant VSVs carrying foreign antigens on the surface of the virus particle may be useful for viral targeting, membrane protein purification, and for generation of immune responses...
  68. pmc The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity
    V von Messling
    Molecular Medicine Program, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Virol 75:6418-27. 2001
    ..All these characteristics were found to be predominantly mediated by the H protein regardless of the viral backbone used...
  69. ncbi Measles virus circulation in Argentina: 1991-1999
    P R Barrero
    , , Buenos Aires, Argentina
    Arch Virol 146:815-23. 2001
    ..The C1 genotype has not been detected since 1994 and the finding that a single D6 virus was found in November 1999 demonstrates that wild type viruses are still circulating among a partially covered population...
  70. ncbi Disruption of Akt kinase activation is important for immunosuppression induced by measles virus
    E Avota
    Institute for Virology and Immunobiology, , , Germany
    Nat Med 7:725-31. 2001
    ..Thus, we show here that MV exploits a novel strategy to interfere with T-cell activation during immunosuppression...
  71. ncbi Mechanism of measles virus-induced suppression of inflammatory immune responses
    J C Marie
    INSERM U503, CERVI, Immunobiologie Fondamentale et Clinique, 69365, Lyon, France
    Immunity 14:69-79. 2001
    ..These results introduce a novel model for testing the immunosuppressive potential of anti-measles vaccines and reveal a specific mechanism of MV-induced modulation of inflammatory reactions...
  72. pmc Importance of the cytoplasmic tails of the measles virus glycoproteins for fusogenic activity and the generation of recombinant measles viruses
    Markus Moll
    Institute of Virology, Philipps University of Marburg, Marburg, Germany
    J Virol 76:7174-86. 2002
    ..Thus, glycoprotein truncation does not interfere with the successful generation of recombinant MV if fusion competence is maintained...
  73. pmc Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion
    Markus U Ehrengruber
    Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
    J Virol 76:5720-8. 2002
    ..The detected localization of MV proteins suggests that local microfusion events may be mediated by the F protein at sites of synaptic contacts and is consistent with a mechanism of retrograde transmission of MV infection...
  74. ncbi The haemagglutinin protein is an important determinant of measles virus tropism for dendritic cells in vitro
    S Ohgimoto
    Institute for Virology and Immunobiology, , Versbacher Str. 7, , Germany
    J Gen Virol 82:1835-44. 2001
    ..This study suggests that the MV H protein plays an important role in determining cell tropism to immune cells and this may play an important role in the induction of immunosuppression in vivo...
  75. ncbi Evaluation of the replication and immunogenicity of recombinant human parainfluenza virus type 3 vectors expressing up to three foreign glycoproteins
    Mario H Skiadopoulos
    Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 297:136-52. 2002
    ..Thus, it is possible to use a single HPIV vector expressing two foreign gene inserts to protect infants and young children from the severe lower respiratory tract disease caused by the three major human PIV pathogens...
  76. ncbi CDw150(SLAM) is a receptor for a lymphotropic strain of measles virus and may account for the immunosuppressive properties of this virus
    E C Hsu
    Amgen Research Institute, 620 University Avenue, Suite 706, Toronto, Ontario, M5G 2C1, Canada
    Virology 279:9-21. 2001
    ..These infections were independent of the presence of CD46 on the host cell surface. Interaction of measles virus with CDw150(SLAM) could explain the immunosuppressive properties of this virus...
  77. ncbi Application of deglycosylation and electrophoresis to the quantification of influenza viral hemagglutinins facilitating the production of 2009 pandemic influenza (H1N1) vaccines at multiple manufacturing sites in China
    Changgui Li
    National Institute for the Control of Pharmaceutical and Biological Products, No 2, Tiantan Xili, Beijing, 100050, PR China
    Biologicals 38:284-9. 2010
    ..The alternative method for vaccine quantification enabled the Chinese health authority to approve H1N1 vaccine 1 month earlier than otherwise possible...
  78. pmc NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus
    Michal Mendelson
    Department of Microbiology and Immunology and the National Institute for Biotechnology in the Negev, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Virol 84:3789-97. 2010
    ..This study shed light on the O-glycan sequences involved in the interaction of glycoprotein and viral hemagglutinins and may help in the design of agents inhibitory to hemagglutinin for influenza treatment.
  79. pmc Functional and structural analysis of the sialic acid-binding domain of rotaviruses
    P Isa
    Departamento de Genetica y Fisiologia Molecular, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    J Virol 71:6749-56. 1997
    ..Tyrosines were primarily targeted since tyrosine has been involved in the interaction of other viral hemagglutinins with SA...
  80. ncbi A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide
    Changgui Li
    National Institute for the Control of Pharmaceutical and Biological Products, The State Food and Drug Administration, Beijing, P R China
    Nat Protoc 5:14-9. 2010
    ..The entire procedure takes only 5 h and can be applied to the quantitative determination of virtually all influenza viral HAs using a single antibody targeting the fusion peptide...
  81. ncbi Role of the key mutation in the selective binding of avian and human influenza hemagglutinin to sialosides revealed by quantum-mechanical calculations
    Toshihiko Sawada
    Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Am Chem Soc 132:16862-72. 2010
    The selective binding between avian and human influenza A viral hemagglutinins (HA) subtype H3 and Neu5Acα2-3 and α2-6Gal (avian α2-3, human α2-6) is qualitatively rationalized by the fragment molecular orbital (FMO) method...
  82. ncbi Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus
    Anwar M Hashem
    Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada
    Biochem Biophys Res Commun 403:247-51. 2010
    ..Here we demonstrate that these universal antibodies bind to the viral hemagglutinins in native conformation presented in infected mammalian cell cultures and neutralize multiple subtypes of ..
  83. ncbi The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46
    Tal I Arnon
    Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
    Blood 103:664-72. 2004
    ..This residue plays a critical dual role in NKp46 interactions with both viral hemagglutinins and the unknown tumor ligands via different mechanisms...
  84. ncbi Humoral response to influenza hemagglutinin: oligoclonal spectrotype and failure of thymopentin as immunoadjuvant
    R Biselli
    Istituto di Medicina Interna, Universita di Padova, Italia
    Gerontology 41:3-10. 1995
    ..These results further emphasize the limited immunogenicity of influenza vaccination and the inefficacy of TP-5 as immunoadjuvant, in this model of vaccination...
  85. ncbi Hemadsorption expressed by cloned H genes from subacute sclerosing panencephalitis (SSPE) viruses and their possible progenitor measles viruses isolated in Osaka, Japan
    K Furukawa
    Department of Virology, Osaka City University Medical School, Osaka, Japan
    Microbiol Immunol 45:59-68. 2001
    ....
  86. ncbi Sequence divergence of measles virus haemagglutinin during natural evolution and adaptation to cell culture
    B K Rima
    School of Biology and Biochemistry, The Queen s University of Belfast, UK
    J Gen Virol 78:97-106. 1997
    ..In contrast, rodent brain-adapted viruses displayed a lot of amino acid sequence variation from normal MV strains. There was no convincing evidence for recombination between MV genotypes...
  87. ncbi Inhibition of influenza virus fusion by polyanionic proteins
    P Schoen
    Groningen Utrecht Institute for Drug Exploration GUIDE, University of Groningen, Department of Physiological Chemistry, Faculty of Medical Sciences, The Netherlands
    Biochem Pharmacol 53:995-1003. 1997
    ....
  88. ncbi Preparation of influenza virosome vaccine with muramyldipeptide derivative B30-MDP
    S Ando
    Tokyo R and D Center, Daiichi Pharmaceutical Co, Ltd, Japan
    J Microencapsul 14:79-90. 1997
    ....
  89. ncbi [Anti-measles DNA-immunization in experiment: immunogenicity and safety]
    N L Maksimov
    Vopr Virusol 50:4-9. 2005
    ..And it was present on days 7 and 14 in the red bone marrow, spleen, muscular tissue, lungs and fatty tissue. On day 21 the plasmid DNA was not detected in any of the investigated organs...
  90. pmc In vitro assessment of attachment pattern and replication efficiency of H5N1 influenza A viruses with altered receptor specificity
    Salin Chutinimitkul
    Department of Virology and National Influenza Center, Erasmus MC, P O Box 2040, 3000CA Rotterdam, Netherlands
    J Virol 84:6825-33. 2010
    ....
  91. ncbi Recent structural solutions for antibody neutralization of viruses
    P L Stewart
    Dept of Molecular and Medical Pharmacology, UCLA School of Medicine 90095 1770, USA
    Trends Microbiol 5:229-33. 1997
    ..Crystallography and cryoelectron microscopy can reveal the structural relationship between receptor-binding sites and neutralization epitopes, as well as whether molecular rearrangements occur upon antibody binding...
  92. ncbi Genetic and antigenic characterization of measles viruses that circulated in Korea during the 2000-2001 epidemic
    Byoung Kuk Na
    Department of Virology, National Institute of Health, Seoul, Korea
    J Med Virol 70:649-54. 2003
    ....
  93. ncbi An investigation of incorporation of cellular antigens into vaccinia virus particles
    Oliver Krauss
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    J Gen Virol 83:2347-59. 2002
    ..Lastly, the VV haemagglutinin was absent from one-third of IEV and CEV/EEV particles, whereas other EEV antigens were present in all these virions...
  94. pmc Atomic-resolution simulations predict a transition state for vesicle fusion defined by contact of a few lipid tails
    Peter M Kasson
    Department of Chemistry, Stanford University, Stanford, California, United States of America
    PLoS Comput Biol 6:e1000829. 2010
    ..Our results thus suggest that the specific molecular properties of individual lipids are highly important to vesicle fusion and yield an explicit structural model that could help explain the mechanism of catalysis by fusion proteins...
  95. ncbi [The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice]
    Iu A Desheva
    Vopr Virusol 52:27-30. 2007
    ....
  96. pmc Selectively receptor-blind measles viruses: Identification of residues necessary for SLAM- or CD46-induced fusion and their localization on a new hemagglutinin structural model
    Sompong Vongpunsawad
    Molecular Medicine Program, Mayo Clinic, and Virology and Gene Therapy, Mayo Graduate School, Rochester, Minnesota 55095, USA
    J Virol 78:302-13. 2004
    ..Selectively receptor-blind viruses will be used to study MV pathogenesis and may have applications for the production of novel vaccines and therapeutics...
  97. ncbi Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis virus. III. Nucleotide sequence of the hemagglutinin gene
    K Komase
    Laboratory Animal Research Center, University of Tokyo, Japan
    Virus Genes 4:163-72. 1990
    ..These results suggested that the H protein of the Yamagata-1 strain of defective SSPE virus is structurally and functionally similar to that of the Edmonston strain of MV...
  98. ncbi Recombinant wild-type measles virus containing a single N481Y substitution in its haemagglutinin cannot use receptor CD46 as efficiently as that having the haemagglutinin of the Edmonston laboratory strain
    Fumio Seki
    Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    J Gen Virol 87:1643-8. 2006
    ..This may be a reason why few CD46-using MVs are detected in vivo...
  99. pmc Modeling of the endosomolytic activity of HA2-TAT peptides with red blood cells and ghosts
    Ya Jung Lee
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    Biochemistry 49:7854-66. 2010
    ..Taken together, these results suggest a model for the endosomolytic activity of the peptide and provide the basis for the molecular design of future delivery agents...
  100. pmc Genetic basis for T cell recognition of a major histocompatibility complex class II-restricted neo-self peptide
    D M Cerasoli
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Exp Med 182:1327-36. 1995
    ..Thus, tolerance to PR8 S1 as a self peptide does not limit the diversity of the T cell response to S1(K113)...
  101. ncbi Molecular mimicry by major histocompatibility complex molecules and peptides accounts for some alloresponses
    R I Lechler
    Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Immunol Lett 34:63-9. 1992
    ..These data support the concept that allorecognition in some responder/stimulator combinations can be explained by cross-reactivity at the level of the MHC molecule and the peptide...

Research Grants34

  1. Enhancing Collectin Mediated Defense Against Influenza
    Kevan L Hartshorn; Fiscal Year: 2013
    ..We will use purified viral hemagglutinins, novel recombinant viral strains, viral binding assays, and in vitro and in vivo assays of viral inhibition...
  2. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  3. Retrocyclins: Cyclic mini-defensins that inactivate anthrax toxins
    ROBERT IRVING contact LEHRER; Fiscal Year: 2010
    ..anthracis spores in mouse models as per the revised Specific Aims. All remaining Aims can be addressed in a two-year time period. PHS ..
  4. M2 peptide based vaccines against influenza
    Andrew Pekosz; Fiscal Year: 2008
    ..Finally, we will investigate the mechanism by which M2 antibodies confer protection in vivo and characterize the replication and virulence of M2 antibody escape mutants. [unreadable] [unreadable]..
  5. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2007
    ..abstract_text> ..
  6. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2007
    ..The study should provide new and useful information -- both for our understanding of RSV pathogenesis and for the development of an effective RSV vaccine. ..
  7. Structure/biology of short-lived MHC II-ligand complexes
    Scheherazade Sadegh Nasseri; Fiscal Year: 2007
    ..Compare peptide repertoires of DO-/-, DM-/- and WT thymic stromal cells 3b. Generate mice expressing a DR1 mutant (DRbG86Y) that participates in short-lived complexes and study thymocyte selection. ..
  8. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
    ..These experiments should yield important insights into basic collection biology and demonstrate that enhancement of collectin-mediated pulmonary host defense can be achieved in vivo through rational alteration of wild type collectins. ..
  9. Macromolecular X-ray Structure Facility Instrumentation
    Andrew Mesecar; Fiscal Year: 2003
    ....
  10. A Molecular Basis for Phytoestrogen Chemoprevention
    Andrew Mesecar; Fiscal Year: 2002
    ..aid in the design of new compounds that can serve as selective estrogen modulators (SERMs). ..
  11. Rotavirus VP4: Structure and function
    Stephen Harrison; Fiscal Year: 2007
    ..abstract_text> ..
  12. STRUCTURE/FUNCTIONS OF HUMAN TEAR LIPOPHILIN
    Robert Lehrer; Fiscal Year: 2001
    ..The long-term objectives for this research are to learn how lipophilin contributes to corneal and conjuctival health, and to explore its potential for creating new diagnostic and therapeutic modalities. ..
  13. Multivalent display of anthrax toxin inhibitors
    Marianne Manchester; Fiscal Year: 2007
    ..abstract_text> ..
  14. DEFENSINS--ANTIMICROBIAL PEPTIDES OF HUMAN NEUTROPHILS
    Robert Lehrer; Fiscal Year: 2002
    ..The work with murine neutrophils, whose content of endogenous antimicrobial polypeptides differs greatly from those of humans, will provide essential information relevant to the interpretation of murine models of human infection. ..
  15. Retargeted Oncolytic Measles Viruses Displaying Single-Chain Antibodies
    Kah Whye Peng; Fiscal Year: 2010
    ..3) To determine the relationship between affinity of displayed scFv and virus entry or cell fusion of retargeted MVs. ..
  16. IL-6 IN HERPES SIMPLEX VIRUS TYPE 1 OCULAR REACTIVATION
    JOHN KRIESEL; Fiscal Year: 2002
    ..Novel and specific viral mutants will be constructed based on the results of HSV-DNA binding and transient expression assays. ..
  17. A Novel Genetic Therapy for Herpes Keratitis
    JOHN KRIESEL; Fiscal Year: 2006
    ..An ex vivo model of HSV-1 reactivation in explanted mouse trigeminal ganglia is proposed as an efficient means for determining effective strategies for the delay or inhibition of reactivation. ..
  18. Hantavirus genetics and respiratory cell interactions
    Andrew Pekosz; Fiscal Year: 2003
    ..The proposed studies will serve to advance our knowledge of HPS pathogenesis as well as lay the groundwork for the rational design of HPS vaccines and therapies. ..
  19. Isolation of Autoantibodies to Apoptotic Cells
    Marko Radic; Fiscal Year: 2004
    ..The results of these studies will allow a fuller assessment of the role of apoptotic cells in the induction of B cell tolerance or autoimmunity. ..
  20. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Bruno Sainz; Fiscal Year: 2004
    ..The goal of the studies proposed herein is to elucidate the mechanism(s) by which IFN-beta and IFN-gamma inhibit HSV-1 replication and to identify the cellular factors that are involved in this process. ..
  21. Modeling of Multivalent Vaccination for Variable Viruses
    MICHAEL DEEM; Fiscal Year: 2005
    ..The proposed work allows investigation and determination of the qualitative and quantitative features that govern the interaction between an effective multivalent vaccine and the variability of the virus. ..
  22. Structure-Based Design of Nipah Virus Entry Inhibitors
    RICHARD PLEMPER; Fiscal Year: 2006
    ..These will be characterized for their activity against live Nipah (aim 3). ..
  23. Influenza virus assembly and virulence
    Andrew Pekosz; Fiscal Year: 2007
    ..abstract_text> ..
  24. 4th International Conference on Oncolytic Viruses as Cancer Therapeutics
    Kah Whye Peng; Fiscal Year: 2007
    ..This provides an important training ground for tomorrow's scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
  25. ALTRUINS, NATURAL ANTIBIOTICS OF THE MALE GENITAL TRACT
    Robert Lehrer; Fiscal Year: 2001
    ..S. are sexually transmitted. According to CDC estimates, STDs other than AIDS add 10 billion dollars to the nation's annual health care I costs. The proposed studies could lead to novel approaches for STD prophylaxis. ..
  26. Biacore 3000 SPR Instrument
    Robert Lehrer; Fiscal Year: 2004
    ..These include the development of new agents and approaches to prevent and treat infections caused by HIV-1 and other viral pathogens, and fundamental issues related to cell targeting and survival. ..
  27. Theta-defensins Novel HIV-1 Uptake Inhibitors
    Robert Lehrer; Fiscal Year: 2007
    ..Specific Aim 2 will be realized by a combination of microchemical techniques, including surface plasmon resonance, tandem mass spectrometry, and state-of-the-art lectinomic and peptidomic chemistry. ..
  28. High Throughput Screening-Based Identification of Measles Virus Probes
    RICHARD PLEMPER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. Small Molecule X-Ray Diffraction Instrumentation
    Andrew Mesecar; Fiscal Year: 2002
    ..abstract_text> ..
  30. ALPHA HELICAL CATHELICIDINS AND HOST DEFENSE
    Robert Lehrer; Fiscal Year: 2003
    ..The experiments will expand our knowledge about these important peptides, and should provide the information needed to develop them as antibiotics for topical bronchopulmonary use in cystic fibrosis. ..
  31. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Cell culture animal models for SARS-CoV
    Andrew Pekosz; Fiscal Year: 2005
    ..Successful completion of the aims outlined in this application will establish systems for investigating the cell biology and pathogenesis of SARS-CoV. ..
  33. Novel Organophosphorous Hydrolases for Decontamination
    Andrew Mesecar; Fiscal Year: 2007
    ..unreadable] [unreadable]..