viral hemagglutinins

Summary

Top Publications

  1. ncbi The influenza C virus glycoprotein (HE) exhibits receptor-binding (hemagglutinin) and receptor-destroying (esterase) activities
    R Vlasak
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029
    Virology 160:419-25. 1987
  2. ncbi Resistant influenza A viruses in children treated with oseltamivir: descriptive study
    Maki Kiso
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Lancet 364:759-65. 2004
  3. pmc Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates
    Y P Lin
    Division of Virology, National Institute for Medical Research, Mill Hill, London, United Kingdom Dise
    Proc Natl Acad Sci U S A 97:9654-8. 2000
  4. doi Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins
    Stella Chun
    Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, Ontario, Canada
    Vaccine 26:6068-76. 2008
  5. pmc 9-O-acetylated sialic acids have widespread but selective expression: analysis using a chimeric dual-function probe derived from influenza C hemagglutinin-esterase
    A Klein
    Glycobiology Program, Cancer Center, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 91:7782-6. 1994
  6. ncbi Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection
    M Gocník
    Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic
    J Gen Virol 88:951-5. 2007
  7. ncbi Glycan analysis in cell culture-based influenza vaccine production: influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin
    Jana Schwarzer
    Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, 39106 Magdeburg, Germany
    Vaccine 27:4325-36. 2009
  8. ncbi Measles virus strains circulating in Central and West Africa: Geographical distribution of two B3 genotypes
    D Waku Kouomou
    INSERM U404, CERVI, Lyon Cedex, France
    J Med Virol 68:433-40. 2002
  9. ncbi Genetic characterization of wild-type measles viruses circulating in suburban Khartoum, 1997-2000
    H S El Mubarak
    Institute of Virology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Gen Virol 83:1437-43. 2002
  10. ncbi Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype
    G Winter
    Nature 292:72-5. 1981

Detail Information

Publications163 found, 100 shown here

  1. ncbi The influenza C virus glycoprotein (HE) exhibits receptor-binding (hemagglutinin) and receptor-destroying (esterase) activities
    R Vlasak
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029
    Virology 160:419-25. 1987
    ..In analogy to the parainfluenza virus HN protein, the influenza C virus glycoprotein was termed HE, because it possesses hemagglutinin and esterase (receptor-destroying) activity...
  2. ncbi Resistant influenza A viruses in children treated with oseltamivir: descriptive study
    Maki Kiso
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Lancet 364:759-65. 2004
    ..Our aim was to investigate oseltamivir resistance in a group of children treated for influenza...
  3. pmc Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates
    Y P Lin
    Division of Virology, National Institute for Medical Research, Mill Hill, London, United Kingdom Dise
    Proc Natl Acad Sci U S A 97:9654-8. 2000
    ..This common feature emphasizes the apparent propensity of avian viruses with this genetic complement to infect humans and highlights the potential for the emergence of a novel human pathogen...
  4. doi Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins
    Stella Chun
    Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, Ontario, Canada
    Vaccine 26:6068-76. 2008
    ..remarkable specificity against the viral sequences and robustness of quantitatively analyzing the viral hemagglutinins even under stringent conditions...
  5. pmc 9-O-acetylated sialic acids have widespread but selective expression: analysis using a chimeric dual-function probe derived from influenza C hemagglutinin-esterase
    A Klein
    Glycobiology Program, Cancer Center, University of California, San Diego, La Jolla 92093
    Proc Natl Acad Sci U S A 91:7782-6. 1994
    ..Thus, 9-O-acetylation is more widespread than previously thought and occurs on specific molecules and cell types...
  6. ncbi Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection
    M Gocník
    Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic
    J Gen Virol 88:951-5. 2007
    ..It is concluded that antibodies specific to the antigenically conserved HA2 glycopolypeptide that exhibit fusion-inhibition activity can contribute to the protection of infected mice and mediate more effective recovery from infection...
  7. ncbi Glycan analysis in cell culture-based influenza vaccine production: influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin
    Jana Schwarzer
    Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, 39106 Magdeburg, Germany
    Vaccine 27:4325-36. 2009
    ..In contrast to this, a principal switch of the N-glycan type attached to HA was observed when comparing different virus types (A and B) and subtypes (H1N1 and H3N2)...
  8. ncbi Measles virus strains circulating in Central and West Africa: Geographical distribution of two B3 genotypes
    D Waku Kouomou
    INSERM U404, CERVI, Lyon Cedex, France
    J Med Virol 68:433-40. 2002
    ..2 genotype is found in West Africa. In Nigeria and Ghana, the viruses co-circulate. The identification of these viruses will permit more meaningful epidemiological studies after the proposed increase in measles vaccination coverage...
  9. ncbi Genetic characterization of wild-type measles viruses circulating in suburban Khartoum, 1997-2000
    H S El Mubarak
    Institute of Virology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Gen Virol 83:1437-43. 2002
    ..Our study demonstrates a remarkable genetic stability of an endemically circulating MV strain...
  10. ncbi Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype
    G Winter
    Nature 292:72-5. 1981
  11. ncbi Type A influenza virus surveillance in free-flying, nonmigratory ducks residing on the eastern shore of Maryland
    R D Slemons
    Department of Veterinary Preventive Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA
    Avian Dis 47:1107-10. 2003
    ....
  12. ncbi Genetic characterization of contemporary wild-type measles viruses from Vietnam and the People's Republic of China: identification of two genotypes within clade H
    S L Liffick
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, 30333, Atlanta, GA, USA
    Virus Res 77:81-7. 2001
    ..Sequence analysis of measles viruses imported into the United States from either China or Vietnam demonstrated that this designation of genotypes will be helpful in future measles surveillance activities...
  13. ncbi Receptor-binding properties of swine influenza viruses isolated and propagated in MDCK cells
    Alexandra S Gambaryan
    Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, 142782 Moscow, Russia
    Virus Res 114:15-22. 2005
    ....
  14. ncbi Phylogenetic and restriction fragment length polymorphism analyses of hemagglutinin (H) protein of canine distemper virus isolates from domestic dogs in Japan
    Masashi Uema
    Laboratory of Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai Minato ku, Tokyo 108 8639, Japan
    Virus Res 109:59-63. 2005
    ..Thus, the RFLP method is useful for differentiating the infections with field CDV strains from the vaccine strains in clinical cases...
  15. pmc Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells
    Fumio Seki
    Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    J Virol 77:9943-50. 2003
    ..Our results indicate that Vero cells stably expressing canine SLAM are highly sensitive to CDV in clinical specimens and that only a single amino acid substitution in the hemagglutinin can allow the virus to adapt to marmoset SLAM...
  16. ncbi Receptor-binding properties of modern human influenza viruses primarily isolated in Vero and MDCK cells and chicken embryonated eggs
    Larisa Mochalova
    Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho Maklaya 16 10, 117997 Moscow, Russia
    Virology 313:473-80. 2003
    ..These HA mutations disturb the observed strict 6'SLN specificity of recent human influenza viruses...
  17. pmc Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses
    Aleksandr S Lipatov
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, Georgia, United States of America
    PLoS Pathog 4:e1000102. 2008
    ....
  18. ncbi Pathobiology of H5N2 Mexican avian influenza virus infections of chickens
    D E Swayne
    US Department of Agriculture, Southeast Poultry Research Laboratory, Athens, GA, USA
    Vet Pathol 34:557-67. 1997
    ....
  19. ncbi Comparative analyses of canine distemper viral isolates from clinical cases of canine distemper in vaccinated dogs
    N T Lan
    Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889 2192, Japan
    Vet Microbiol 115:32-42. 2006
    ..These results surely indicate that wild strains of CDV from dogs with a vaccination history were not reversed vaccine virus, and that the dogs showed characteristics of recent CD in Japan...
  20. pmc Interspecies and intraspecies transmission of triple reassortant H3N2 influenza A viruses
    Hadi M Yassine
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA
    Virol J 4:129. 2007
    ..Identifying viruses with varying inter- and intra-species transmission potential should be useful for further studies on the molecular basis of interspecies transmission...
  21. ncbi Origin of the pandemic 1957 H2 influenza A virus and the persistence of its possible progenitors in the avian reservoir
    J R Schafer
    St Jude Children s Research Hospital, Department of Virology Molecular Biology, Memphis, Tennessee 38105
    Virology 194:781-8. 1993
    ..We conclude that antigenically conserved counterparts of the human Asian pandemic strain of 1957 continue to circulate in the avian reservoir and are coming into closer proximity to susceptible human populations...
  22. pmc Plasticity of influenza haemagglutinin fusion peptides and their interaction with lipid bilayers
    Loredana Vaccaro
    National Institute for Medical Research, London, United Kingdom
    Biophys J 88:25-36. 2005
    ..These results confirm that the sequence can adopt different folds in different environments. The plasticity and the conformational dependence on the local environment could be used to better understand the function of fusion peptides...
  23. ncbi Genetic analysis of measles viruses isolated in Morocco
    Amal Alla
    Institute of Health, Rabat, Morocco
    J Med Virol 68:441-4. 2002
    ..Knowledge of the indigenous strain of measles virus circulating in Morocco will help to describe viral transmission pathways and should contribute to efforts to evaluate the effectiveness of future vaccination campaigns...
  24. pmc Bilayer conformation of fusion peptide of influenza virus hemagglutinin: a molecular dynamics simulation study
    Qiang Huang
    Department of Chemistry, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
    Biophys J 87:14-22. 2004
    ..The average hydrophobic thickness of the lipid phase close to the N-terminus is reduced in comparison with the average hydrophobic thickness of a pure dimyristoyl phosphatidylcholine bilayer...
  25. ncbi Molecular dynamics simulations of the influenza hemagglutinin fusion peptide in micelles and bilayers: conformational analysis of peptide and lipids
    Patrick Lagüe
    Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852 1448, USA
    J Mol Biol 354:1129-41. 2005
    ..An extension of the classical surfactant theory of Israelachvili based on shapes is proposed to introduce the concept of a "dynamically induced shape" of the membrane lipids by the peptide...
  26. ncbi Sequence analysis of measles virus strains collected during the pre- and early-vaccination era in Denmark reveals a considerable diversity of ancient strains
    L Siig Christensen
    Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
    APMIS 110:113-22. 2002
    ....
  27. pmc Expression of hemagglutinin esterase protein from recombinant mouse hepatitis virus enhances neurovirulence
    Lubna Kazi
    Department of Microbiology, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 79:15064-73. 2005
    ....
  28. ncbi Neutralizing B cell response in measles
    Fabienne B Bouche
    Department of Immunology and WHO Collaborating Center for Measles, Laboratoire National de Santé, Luxembourg, Luxembourg
    Viral Immunol 15:451-71. 2002
    ..Major neutralizing epitopes have been mapped mainly on the hemagglutinin protein with monoclonal antibodies, producing an increasingly comprehensive map of functional domains...
  29. ncbi Measles virus exploits dendritic cells to suppress CD4+ T-cell proliferation via expression of surface viral glycoproteins independently of T-cell trans-infection
    B Dubois
    , IFR 74, CERVI, , Lyon, France
    Cell Immunol 214:173-83. 2001
    ....
  30. ncbi Large-scale preparation of biologically active measles virus haemagglutinin expressed by attenuated vaccinia virus vectors
    Minoru Kidokoro
    Department of Research and Development, Chiba Serum Institute, 2 6 1 Kohnodai, Ichikawa, Chiba 272 0827, Japan
    Microbes Infect 4:1035-44. 2002
    ..Such recombinant haemagglutinin preparations will be useful in diagnostic tests that measure functional anti-measles immunity and investigate the biological functions and structure of the haemagglutinin...
  31. pmc New measles genotype, Uganda
    Apollo Muwonge
    Uganda Virus Research Institute, Entebbe, Uganda
    Emerg Infect Dis 11:1522-6. 2005
    ..Therefore, Ugandan viruses should be considered a new, proposed genotype (d10). This new sequence information will expand the utility of molecular epidemiologic techniques for describing measles transmission patterns in eastern Africa...
  32. pmc Efficiency of measles virus entry and dissemination through different receptors
    Urs Schneider
    Molecular Medicine Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Virol 76:7460-7. 2002
    ..To verify the importance of these observations for human infections, we examined MV entry into peripheral blood mononuclear cells and observed that viruses with asparagine 481 H proteins infect these cells more efficiently...
  33. pmc Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine
    Diane E Webster
    Department of Medicine, Monash University Medical School, Alfred Hospital, Prahran, Victoria 3181, Australia
    J Virol 76:7910-2. 2002
    ..This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology...
  34. ncbi H1 genotype of measles virus was detected in outbreaks in Japan after 2000
    Jianhui Zhou
    Laboratory of Viral Infection, Kitasato Institute for Life Sciences, Tokyo, Japan
    J Med Virol 70:642-8. 2003
    ..However, some D3 and H1 strains were not completely neutralized with low levels of neutralizing antibody, and maintaining high levels of measles antibodies would be required for the control measles outbreaks...
  35. ncbi Genetic and antigenic characterization of measles viruses that circulated in Korea during the 2000-2001 epidemic
    Byoung Kuk Na
    Department of Virology, National Institute of Health, Seoul, Korea
    J Med Virol 70:649-54. 2003
    ....
  36. ncbi Neuraminidase activity assays for monitoring MDCK cell culture derived influenza virus
    Deba Prasad Nayak
    Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstreet 1, D 39106 Magdeburg, Germany
    J Virol Methods 122:9-15. 2004
    ..Based on the hemagglutinin and neuraminidase activity of the clarified and inactivated virus harvest, the overall recovery after gel filtration was about 34.4% and 119.5%, respectively...
  37. pmc Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles
    Chien Hsiung Pan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:11581-8. 2005
    ..Viremia was cleared within 14 days, but MV RNA was detectable for 4-5 months. These studies suggest that complete clearance of MV after infection is a prolonged, phased, and complex process influenced by prior vaccination...
  38. ncbi [Influenza viruses which preconditioned the epidemic rise in Russia in 2002-2003. A resumed circulation of influenza viruses similar to V/Victoria/2/87]
    V T Ivanova
    Vopr Virusol 49:12-7. 2004
    ..A study of paired sera obtained from patients showed a growth of antibodies to the etalons of influenza A(H1N1), A(H3N2) and B viruses of the season in question, which confirmed the virology data...
  39. ncbi Effective primary isolation of wild-type canine distemper virus in MDCK, MV1 Lu and Vero cells without nucleotide sequence changes within the entire haemagglutinin protein gene and in subgenomic sections of the fusion and phospho protein genes
    John A Lednicky
    Department of Pathology, Loyola University Medical Center, 2160 South First Street, Maywood, IL 60153, USA
    J Virol Methods 118:147-57. 2004
    ..Different viral phenotypes and genotypes were detected. The conservation of H gene sequences in primary CDV isolates suggests that MDCK, MV1 Lu, and Vero cells express proper receptors for wild-type CDV...
  40. ncbi Polarized glycoprotein targeting affects the spread of measles virus in vitro and in vivo
    Markus Moll
    Institute of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
    J Gen Virol 85:1019-27. 2004
    ..These data strongly suggest that basolateral targeting of MV glycoproteins helps to overcome the epithelial barrier and thereby facilitates the systemic spread of MV infection in vivo...
  41. pmc Relative contributions of measles virus hemagglutinin- and fusion protein-specific serum antibodies to virus neutralization
    Rik L De Swart
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Virol 79:11547-51. 2005
    ..These results demonstrate that measles virus neutralizing antibodies are mainly directed to the H protein...
  42. pmc Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain
    Emmie de Wit
    Department of Virology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 79:12401-7. 2005
    ..The data presented suggest that vaccine candidates based on low-pathogenicity avian influenza A viruses, which can be prepared ahead of pandemic threats, can be efficacious if an effective adjuvant is used...
  43. ncbi Baculovirus display of fusion protein of Peste des petits ruminants virus and hemagglutination protein of Rinderpest virus and immunogenicity of the displayed proteins in mouse model
    Md Masmudur Rahman
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    Virology 317:36-49. 2003
    ..The antigenic epitopes of the recombinant proteins were properly displayed and the recombinant virus particles induced immune response in mice against PPRV or RPV...
  44. ncbi Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA and M2 proteins
    George P Leser
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
    Virology 342:215-27. 2005
    ..Quantification of the distribution of surface expressed HA by examining serial sections of virus-infected cells suggests that the HA-containing microdomains give rise to regions of influenza assembly and budding...
  45. ncbi Development of quantitative gene-specific real-time RT-PCR assays for the detection of measles virus in clinical specimens
    Kimberly B Hummel
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, 1600 Clifton Road, Mailstop C 22, Atlanta, GA 30333, USA
    J Virol Methods 132:166-73. 2006
    ....
  46. ncbi Multiple genotypes of nonpathogenic H6N2 influenza viruses isolated from chickens in California
    R J Webby
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Avian Dis 47:905-10. 2003
    ..Analysis of the remaining gene segments of the California viruses revealed that three distinct genotypes of H6N2 viruses were present...
  47. ncbi Interactions among measles virus hemagglutinin, fusion protein and cell receptor signaling lymphocyte activation molecule (SLAM) indicating a new fusion-trimer model
    Peng Zhang
    National Key Lab of Virology, College of Life Scince, Wuhan University, Hu Bei, Wuhan 430072, P R China
    J Biochem Mol Biol 38:373-80. 2005
    ..So fusion protein not only is involved in the fusion but also might directly interact with the SLAM to be a new fusion-trimer model, which might account for the infection mechanism of measles virus...
  48. ncbi Successful mucosal immunization of cotton rats in the presence of measles virus-specific antibodies depends on degree of attenuation of vaccine vector and virus dose
    Bernd Schlereth
    Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str 7, 97078 Wuerzburg, Germany
    J Gen Virol 84:2145-51. 2003
    ..This study demonstrates that a lower degree of attenuation is required to be able to immunize in the presence of MV-specific antibodies...
  49. ncbi Virus-like particle (VLP) vaccine conferred complete protection against a lethal influenza virus challenge
    Jose M Galarza
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Viral Immunol 18:244-51. 2005
    ....
  50. ncbi Evaluation of the replication and immunogenicity of recombinant human parainfluenza virus type 3 vectors expressing up to three foreign glycoproteins
    Mario H Skiadopoulos
    Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 297:136-52. 2002
    ..Thus, it is possible to use a single HPIV vector expressing two foreign gene inserts to protect infants and young children from the severe lower respiratory tract disease caused by the three major human PIV pathogens...
  51. ncbi Measles virus circulation in Argentina: 1991-1999
    P R Barrero
    , , Buenos Aires, Argentina
    Arch Virol 146:815-23. 2001
    ..The C1 genotype has not been detected since 1994 and the finding that a single D6 virus was found in November 1999 demonstrates that wild type viruses are still circulating among a partially covered population...
  52. ncbi Disruption of Akt kinase activation is important for immunosuppression induced by measles virus
    E Avota
    Institute for Virology and Immunobiology, , , Germany
    Nat Med 7:725-31. 2001
    ..Thus, we show here that MV exploits a novel strategy to interfere with T-cell activation during immunosuppression...
  53. ncbi A single amino acid change in the cytoplasmic domains of measles virus glycoproteins H and F alters targeting, endocytosis, and cell fusion in polarized Madin-Darby canine kidney cells
    M Moll
    , , D-35037 Marburg, Germany
    J Biol Chem 276:17887-94. 2001
    ..Mutation of the basolateral sorting signal in one of the MV glycoproteins prevented fusion of polarized cells. These results suggest that basolateral expression of the MV glycoproteins favors virus spread in epithelia...
  54. pmc A seven-segmented influenza A virus expressing the influenza C virus glycoprotein HEF
    Qinshan Gao
    Department of Microbiology, Mount Sinai School of Medicine, Box 1124, One Gustave L Levy Place, New York, NY 10029, USA
    J Virol 82:6419-26. 2008
    ..These results support a selective mechanism of viral RNA recruitment to the budding site...
  55. doi Genetic characterization of H1N1, H1N2 and H3N2 swine influenza virus in Thailand
    Salin Chutinimitkul
    Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Arch Virol 153:1049-56. 2008
    ..Furthermore, amino acid substitutions were detected either at the receptor binding site or the antigenic sites of the hemagglutinin gene...
  56. ncbi Mechanism of measles virus-induced suppression of inflammatory immune responses
    J C Marie
    INSERM U503, CERVI, Immunobiologie Fondamentale et Clinique, 69365, Lyon, France
    Immunity 14:69-79. 2001
    ..These results introduce a novel model for testing the immunosuppressive potential of anti-measles vaccines and reveal a specific mechanism of MV-induced modulation of inflammatory reactions...
  57. ncbi Identification of trypsin I as a candidate for influenza A virus and Sendai virus envelope glycoprotein processing protease in rat brain
    Trong Quang Le
    Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima 770 8503, Japan
    Biol Chem 387:467-75. 2006
    ..Our results suggest that trypsin I in the brain potentiates virus multiplication in the pathogenesis and progression of influenza-associated encephalopathy or encephalitis...
  58. pmc Use of Vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virus
    Chien Hsiung Pan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Clin Vaccine Immunol 15:1214-21. 2008
    ..The use of Vaxfectin-formulated DNA is a promising approach to the development of a measles vaccine for young infants...
  59. pmc Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution
    Qinghong Zeng
    Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Sciences, Utrecht University, 3584 CL, Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 105:9065-9. 2008
    ..Our findings offer unique insights into the structural and functional consequences of independent protein evolution after interviral gene exchange and open potential avenues to broad-spectrum antiviral drug design...
  60. pmc Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles
    M J Schnell
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 93:11359-65. 1996
    ..Recombinant VSVs carrying foreign antigens on the surface of the virus particle may be useful for viral targeting, membrane protein purification, and for generation of immune responses...
  61. ncbi Surveillance of avian and swine influenza in the swine population in Taiwan, 2004
    Happy K Shieh
    Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    J Microbiol Immunol Infect 41:231-42. 2008
    ....
  62. ncbi CDw150(SLAM) is a receptor for a lymphotropic strain of measles virus and may account for the immunosuppressive properties of this virus
    E C Hsu
    Amgen Research Institute, 620 University Avenue, Suite 706, Toronto, Ontario, M5G 2C1, Canada
    Virology 279:9-21. 2001
    ..These infections were independent of the presence of CD46 on the host cell surface. Interaction of measles virus with CDw150(SLAM) could explain the immunosuppressive properties of this virus...
  63. pmc The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity
    V von Messling
    Molecular Medicine Program, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Virol 75:6418-27. 2001
    ..All these characteristics were found to be predominantly mediated by the H protein regardless of the viral backbone used...
  64. ncbi The haemagglutinin protein is an important determinant of measles virus tropism for dendritic cells in vitro
    S Ohgimoto
    Institute for Virology and Immunobiology, , Versbacher Str. 7, , Germany
    J Gen Virol 82:1835-44. 2001
    ..This study suggests that the MV H protein plays an important role in determining cell tropism to immune cells and this may play an important role in the induction of immunosuppression in vivo...
  65. pmc Infectivity studies of influenza virus hemagglutinin receptor binding site mutants in mice
    Jeffrey Meisner
    Emory University School of Medicine, Atlanta, GA 30322, USA
    J Virol 82:5079-83. 2008
    ..The capacity of the Y98F mutant to induce antibody responses and the structural locations of HA reversion mutations are examined...
  66. pmc Importance of the cytoplasmic tails of the measles virus glycoproteins for fusogenic activity and the generation of recombinant measles viruses
    Markus Moll
    Institute of Virology, Philipps University of Marburg, Marburg, Germany
    J Virol 76:7174-86. 2002
    ..Thus, glycoprotein truncation does not interfere with the successful generation of recombinant MV if fusion competence is maintained...
  67. ncbi The cowpox virus fusion regulator proteins SPI-3 and hemagglutinin interact in infected and uninfected cells
    Peter C Turner
    Department of Molecular Genetics and Microbiology, Box 100266 1600 SW Archer Road, ARB R2 231, University of Florida, Gainesville, FL 32610 0266, USA
    Virology 347:88-99. 2006
    ..The HA-binding domain in SPI-3 resided in the C-terminal 229 residues, and did not include helix D, which mediates cofactor interaction in many other serpins...
  68. pmc Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion
    Markus U Ehrengruber
    Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
    J Virol 76:5720-8. 2002
    ..The detected localization of MV proteins suggests that local microfusion events may be mediated by the F protein at sites of synaptic contacts and is consistent with a mechanism of retrograde transmission of MV infection...
  69. pmc Immunoglobulin g antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response
    Ianko D Iankov
    Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA
    J Virol 80:8530-40. 2006
    ..The findings point to a new model for the pathogenesis of atypical MV infection observed after immunization with formalin-inactivated MV vaccine and underscore the importance of the anti-F response after vaccination...
  70. ncbi Autocatalytic activation of influenza hemagglutinin
    Jeong H Lee
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 220 South 33rd Street, Philadelphia, PA 19104, USA
    J Mol Biol 364:275-82. 2006
    ..These observations imply a feedback mechanism involving self-catalyzed refolding of HA and thus suggest a mechanism similar to the autocatalytic refolding and aggregation of prions...
  71. ncbi The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD150)
    K Tanaka
    Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Arch Virol 147:195-203. 2002
    ..Thus, the measles virus hemagglutinin can induce downregulation of SLAM in cells either expressing or coming in contact with it...
  72. ncbi Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination
    Martin O Ota
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Infect Dis 195:1799-807. 2007
    ..No single peptide dominated the response. We conclude that H is an important stimulus for CD8+ T cell as well as for antibody responses in HLA-A2-positive individuals...
  73. pmc Adaptation of wild-type measles virus to tissue culture
    Diane Waku Kouomou
    INSERM U 404, CERVI, 69365 Lyon Cedex 07, France
    J Virol 76:1505-9. 2002
    ..The presence of human SLAM expressed in the Vero cells rapidly gave rise to fusion and lower yields of infectious virus...
  74. doi Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes
    Nicole Runkler
    Institute of Virology, Philipps University Marburg, Hans Meerwein Str 2, D 35043 Marburg, Germany
    J Gen Virol 89:687-96. 2008
    ....
  75. pmc Paramyxoviruses: different receptors - different mechanisms of fusion
    Ronald M Iorio
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Trends Microbiol 16:135-7. 2008
    ....
  76. ncbi Sequence analysis of hemagglutinin and nucleoprotein genes of measles viruses isolated in Korea during the 2000 epidemic
    B K Na
    Department of Virology, National Institute of Health, 122-701, Seoul, South Korea
    Virus Res 81:143-9. 2001
    ..4% for the H protein and up to 6.5% for the N protein. Phylogenetic analyses of nucleotide sequences and deduced amino acid sequences of the H and N genes revealed that all Korean viruses were grouped into the clade H1...
  77. ncbi C3d enhancement of neutralizing antibodies to measles hemagglutinin
    T D Green
    Department of Microbiology and Immunology, School of Medicine, East Carolina University, Brody Health Sciences Building, 600 Moye Boulevard, Greenville, NC 27858-4354, USA
    Vaccine 20:242-8. 2001
    ..In addition, sH-3C3d elicited higher neutralizing antibody titers that inhibited MV induced plaque formation...
  78. ncbi Application of deglycosylation and electrophoresis to the quantification of influenza viral hemagglutinins facilitating the production of 2009 pandemic influenza (H1N1) vaccines at multiple manufacturing sites in China
    Changgui Li
    National Institute for the Control of Pharmaceutical and Biological Products, No 2, Tiantan Xili, Beijing, 100050, PR China
    Biologicals 38:284-9. 2010
    ..The alternative method for vaccine quantification enabled the Chinese health authority to approve H1N1 vaccine 1 month earlier than otherwise possible...
  79. pmc NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus
    Michal Mendelson
    Department of Microbiology and Immunology and the National Institute for Biotechnology in the Negev, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Virol 84:3789-97. 2010
    ..This study shed light on the O-glycan sequences involved in the interaction of glycoprotein and viral hemagglutinins and may help in the design of agents inhibitory to hemagglutinin for influenza treatment.
  80. ncbi Role of the key mutation in the selective binding of avian and human influenza hemagglutinin to sialosides revealed by quantum-mechanical calculations
    Toshihiko Sawada
    Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Am Chem Soc 132:16862-72. 2010
    The selective binding between avian and human influenza A viral hemagglutinins (HA) subtype H3 and Neu5Acα2-3 and α2-6Gal (avian α2-3, human α2-6) is qualitatively rationalized by the fragment molecular orbital (FMO) method...
  81. doi A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide
    Changgui Li
    National Institute for the Control of Pharmaceutical and Biological Products, The State Food and Drug Administration, Beijing, P R China
    Nat Protoc 5:14-9. 2010
    ..The entire procedure takes only 5 h and can be applied to the quantitative determination of virtually all influenza viral HAs using a single antibody targeting the fusion peptide...
  82. pmc Functional and structural analysis of the sialic acid-binding domain of rotaviruses
    P Isa
    Departamento de Genetica y Fisiologia Molecular, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    J Virol 71:6749-56. 1997
    ..Tyrosines were primarily targeted since tyrosine has been involved in the interaction of other viral hemagglutinins with SA...
  83. doi Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus
    Anwar M Hashem
    Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada
    Biochem Biophys Res Commun 403:247-51. 2010
    ..Here we demonstrate that these universal antibodies bind to the viral hemagglutinins in native conformation presented in infected mammalian cell cultures and neutralize multiple subtypes of ..
  84. ncbi The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46
    Tal I Arnon
    Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
    Blood 103:664-72. 2004
    ..This residue plays a critical dual role in NKp46 interactions with both viral hemagglutinins and the unknown tumor ligands via different mechanisms...
  85. pmc Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses
    I Margine
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    J Virol 87:10435-46. 2013
    ..by predominantly eliciting antibodies against the membrane distal globular head domain of their respective viral hemagglutinins. This domain, however, undergoes rapid antigenic drift, allowing the virus to escape neutralizing antibody ..
  86. ncbi High level transient expression of the murine coronavirus haemagglutinin-esterase
    M Pfleiderer
    Institute of Virology, University of Wurzburg, Germany
    J Gen Virol 72:1309-15. 1991
    ..The expressed protein has both receptor-destroying (esterase) and receptor-binding (haemadsorption) activities. The use of this system will greatly facilitate analysis of the structure-function relationships of this protein...
  87. ncbi The catalytic triad of the influenza C virus glycoprotein HEF esterase: characterization by site-directed mutagenesis and functional analysis
    S Pleschka
    Institut fur Virologie, Philipps Universitat Marburg, Germany
    J Gen Virol 76:2529-37. 1995
    ..In addition, N280 is proposed to stabilize the oxyanion of the presumptive transition state intermediate formed by the enzyme-substrate complex...
  88. ncbi Structure, sequence, and function correlations among parvoviruses
    M S Chapman
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907
    Virology 194:491-508. 1993
    ....
  89. ncbi Measles virus fusion protein- and hemagglutinin-transfected cell lines are a sensitive tool for the detection of specific antibodies by a FACS-measured immunofluorescence assay
    R L de Swart
    Institute of Virology, Erasmus University, Rotterdam, The Netherlands
    J Virol Methods 71:35-44. 1998
    ....
  90. ncbi Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus
    P B Rosenthal
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 396:92-6. 1998
    ....
  91. ncbi The cytoplasmic tail of the influenza C virus glycoprotein HEF negatively affects transport to the cell surface
    F Oeffner
    Institut fur Virologie, Philipps Universitat Marburg, Germany
    J Gen Virol 80:363-9. 1999
    ..The results show that the short cytoplasmic tail of HEF has a negative effect on the folding and surface transport of this protein. How this effect may be prevented during a virus infection is discussed...
  92. ncbi A bivalent influenza VLP vaccine confers complete inhibition of virus replication in lungs
    Fu Shi Quan
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Vaccine 26:3352-61. 2008
    ..These results indicate that multivalent influenza VLP vaccines can be an effective antigen for developing safe and alternative vaccine to control the spread of influenza viruses...
  93. ncbi Plant-derived measles virus hemagglutinin protein induces neutralizing antibodies in mice
    Z Huang
    Infectious Diseases Unit, Alfred Hospital, Monash University, Commercial Road, Vic. 3181, Prahran, Australia
    Vaccine 19:2163-71. 2001
    ....
  94. ncbi Hemagglutinin genotype profiles of canine distemper virus from domestic dogs in Japan
    M Hashimoto
    Laboratory of Clinical Microbiology, Kyoritsu Shoji Corporation, Tokyo, Japan
    Arch Virol 146:149-55. 2001
    ..One is the native and numerically predominant KDK-1 genotype, while the other is the 98-002 genotype that may have evolved in the Far East beyond the border between Japan and the Republic of Korea...
  95. ncbi Antimeasles immunoglobulin G in sera of patients with otosclerosis is lower than that in healthy people
    S R Lolov
    Department of Molecular Immunology, Institute of Biology and Immunology, Bulgarian Academy of Sciences, 73 Tzatigradskoshousse, 1113 Sofia, Bulgaria
    Otol Neurotol 22:766-70. 2001
    ..In light of the present data, we can discuss autoantibodies in otosclerosis as a sign of autoimmunity triggered by measles virus...
  96. ncbi The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains
    Antonella Pasquato
    Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    J Mol Neurosci 35:339-43. 2008
    ..We hypothesize that the double hemagglutinin mutations in vFJ may result in viruses with less processed hemagglutinin, thereby providing a mechanism for evading immune neutralization...
  97. pmc Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus
    Michelle Roti
    Benaroya Research Institute at Virginia Mason, University of Washington, Seattle, WA 98195, USA
    J Immunol 180:1758-68. 2008
    ....
  98. doi Influenza C virus and bovine coronavirus esterase reveal a similar catalytic mechanism: new insights for drug discovery
    Juliane Mayr
    Applied Biotechnology, Department of Cell Biology, University of Salzburg, Salzburg, Austria
    Glycoconj J 25:393-9. 2008
    ..This study provides valuable insights towards the design of drugs to combat INF-C virus and coronavirus infections causing outbreaks of upper respiratory infections and severe diarrhea in calves, respectively...
  99. doi Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza
    Yoko Shoji
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Vaccine 27:1087-92. 2009
    ..Plants could therefore be suitable as a platform for the rapid, large-scale production of influenza vaccines in the face of a pandemic...
  100. doi Neutralizing monoclonal antibodies to different clades of Influenza A H5N1 viruses
    Sawyin Oh
    Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    J Virol Methods 157:161-7. 2009
    ..These results suggest that the mAbs recognize distinct or overlapping epitopes and will be useful reagents for construction of specific rapid point-of-care assays or for therapeutic use...
  101. ncbi Dynamics of functional maturation and inactivation of HN glycoprotein in NDV-infected chick embryo fibroblasts
    M Lipkind
    Department of Biochemistry, Kimron Veterinary Institute, Beit Dagan, Israel
    Zentralbl Bakteriol Mikrobiol Hyg A 267:432-49. 1988
    ....

Research Grants83

  1. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  2. Immune Responses to Biodefense Vaccines Early in Life
    MARCELA PASETTI; Fiscal Year: 2009
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  3. Immune Responses to Biodefense Vaccines Early in Life
    MARCELA PASETTI; Fiscal Year: 2006
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effective vaccines to prevent diseases early in life. [unreadable] [unreadable] [unreadable]..
  4. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  5. Immune Responses to Biodefense Vaccines Early in Life
    MARCELA PASETTI; Fiscal Year: 2008
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  6. Immune Responses to Biodefense Vaccines Early in Life
    MARCELA PASETTI; Fiscal Year: 2007
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effective vaccines to prevent diseases early in life. [unreadable] [unreadable] [unreadable]..
  7. A. L. lactis-based vaccine for children with broad spectrum for enteric pathogens
    Wendy L Picking; Fiscal Year: 2010
    ..Advantages of this vaccine technology include: an outstanding safety profile, broad protection against multiple pathogens, ease of delivery (mucosal vaccination) and simple and inexpensive production. ..
  8. Multivalent display of anthrax toxin inhibitors
    Marianne Manchester; Fiscal Year: 2007
    ..abstract_text> ..
  9. Influenza virus assembly and virulence
    Andrew Pekosz; Fiscal Year: 2007
    ..abstract_text> ..
  10. Identification and Pre-Clinical Evaluation of Measles Virus Inhibitors
    RICHARD PLEMPER; Fiscal Year: 2006
    ..Characteristic viral escape patterns will be identified for efficacious compounds that warrant future clinical development, and cross-resistance between structurally distinct therapeutic leads will be assessed. ..
  11. A Novel Genetic Therapy for Herpes Keratitis
    JOHN KRIESEL; Fiscal Year: 2006
    ..An ex vivo model of HSV-1 reactivation in explanted mouse trigeminal ganglia is proposed as an efficient means for determining effective strategies for the delay or inhibition of reactivation. ..
  12. Rotavirus VP4: Structure and function
    Stephen Harrison; Fiscal Year: 2007
    ..abstract_text> ..
  13. Retargeted Oncolytic Measles Viruses Displaying Single-Chain Antibodies
    Kah Whye Peng; Fiscal Year: 2009
    ..3) To determine the relationship between affinity of displayed scFv and virus entry or cell fusion of retargeted MVs. ..
  14. Theta-defensins Novel HIV-1 Uptake Inhibitors
    Robert Lehrer; Fiscal Year: 2006
    ..Specific Aim 2 will be realized by a combination of microchemical techniques, including surface plasmon resonance, tandem mass spectrometry, and state-of-the-art lectinomic and peptidomic chemistry. ..
  15. Structure-Based Design of Nipah Virus Entry Inhibitors
    RICHARD PLEMPER; Fiscal Year: 2006
    ..These will be characterized for their activity against live Nipah (aim 3). ..
  16. Retargeted Oncolytic Measles Viruses Displaying Single-Chain Antibodies
    Kah Whye Peng; Fiscal Year: 2006
    ..3) To determine the relationship between affinity of displayed scFv and virus entry or cell fusion of retargeted MVs. ..
  17. Influenza virus assembly and virulence
    Andrew Pekosz; Fiscal Year: 2006
    ..abstract_text> ..
  18. Theta-defensins Novel HIV-1 Uptake Inhibitors
    Robert Lehrer; Fiscal Year: 2005
    ..Specific Aim 2 will be realized by a combination of microchemical techniques, including surface plasmon resonance, tandem mass spectrometry, and state-of-the-art lectinomic and peptidomic chemistry. ..
  19. Modeling of Multivalent Vaccination for Variable Viruses
    MICHAEL DEEM; Fiscal Year: 2005
    ..The proposed work allows investigation and determination of the qualitative and quantitative features that govern the interaction between an effective multivalent vaccine and the variability of the virus. ..
  20. Identification and Pre-Clinical Evaluation of Measles Virus Inhibitors
    RICHARD PLEMPER; Fiscal Year: 2007
    ..Characteristic viral escape patterns will be identified for efficacious compounds that warrant future clinical development, and cross-resistance between structurally distinct therapeutic leads will be assessed. ..
  21. Identification and Pre-Clinical Evaluation of Measles Virus Inhibitors
    Richard K Plemper; Fiscal Year: 2010
    ..Characteristic viral escape patterns will be identified for efficacious compounds that warrant future clinical development, and cross-resistance between structurally distinct therapeutic leads will be assessed. ..
  22. Retargeted Oncolytic Measles Viruses Displaying Single-Chain Antibodies
    Kah Whye Peng; Fiscal Year: 2010
    ..3) To determine the relationship between affinity of displayed scFv and virus entry or cell fusion of retargeted MVs. ..
  23. Structural and Functional Study of Influenza Virus Hemagglutinin
    Qinghua Wang; Fiscal Year: 2010
    ....
  24. Glycoprotein interactions in paramyxovirus fusion
    Ronald M Iorio; Fiscal Year: 2010
    ..abstract_text> ..
  25. Identification and Pre-Clinical Evaluation of Measles Virus Inhibitors
    RICHARD PLEMPER; Fiscal Year: 2009
    ..Characteristic viral escape patterns will be identified for efficacious compounds that warrant future clinical development, and cross-resistance between structurally distinct therapeutic leads will be assessed. ..
  26. STRUCTURE/FUNCTIONS OF HUMAN TEAR LIPOPHILIN
    Robert Lehrer; Fiscal Year: 2001
    ..The long-term objectives for this research are to learn how lipophilin contributes to corneal and conjuctival health, and to explore its potential for creating new diagnostic and therapeutic modalities. ..
  27. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2009
    ..abstract_text> ..
  28. M2 peptide based vaccines against influenza
    Andrew Pekosz; Fiscal Year: 2007
    ..Finally, we will investigate the mechanism by which M2 antibodies confer protection in vivo and characterize the replication and virulence of M2 antibody escape mutants. [unreadable] [unreadable]..
  29. Retrocyclins: Cyclic mini-defensins that inactivate anthrax toxins
    Robert Lehrer; Fiscal Year: 2009
    ..anthracis spores in mouse models as per the revised Specific Aims. All remaining Aims can be addressed in a two-year time period. PHS ..
  30. Identification and Pre-Clinical Evaluation of Measles Virus Inhibitors
    RICHARD PLEMPER; Fiscal Year: 2008
    ..Characteristic viral escape patterns will be identified for efficacious compounds that warrant future clinical development, and cross-resistance between structurally distinct therapeutic leads will be assessed. ..
  31. Retargeted Oncolytic Measles Viruses Displaying Single-Chain Antibodies
    Kah Whye Peng; Fiscal Year: 2008
    ..3) To determine the relationship between affinity of displayed scFv and virus entry or cell fusion of retargeted MVs. ..
  32. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2008
    ..abstract_text> ..
  33. Retargeted Oncolytic Measles Viruses Displaying Single-Chain Antibodies
    Kah Whye Peng; Fiscal Year: 2007
    ..3) To determine the relationship between affinity of displayed scFv and virus entry or cell fusion of retargeted MVs. ..
  34. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2005
    ..This information will help elucidate how these important pathogens gain entry into, and spread between, cells, possibly identifying new anti-viral strategies for their control. ..
  35. ALPHA HELICAL CATHELICIDINS AND HOST DEFENSE
    Robert Lehrer; Fiscal Year: 2000
    ..The experiments will expand our knowledge about these important peptides, and should provide the information needed to develop them as antibiotics for topical bronchopulmonary use in cystic fibrosis. ..
  36. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2000
    ..These experiments should yield important insights into basic collection biology and demonstrate that enhancement of collectin-mediated pulmonary host defense can be achieved in vivo through rational alteration of wild type collectins. ..
  37. DEFENSINS--ANTIMICROBIAL PEPTIDES OF HUMAN NEUTROPHILS
    Robert Lehrer; Fiscal Year: 2002
    ..The work with murine neutrophils, whose content of endogenous antimicrobial polypeptides differs greatly from those of humans, will provide essential information relevant to the interpretation of murine models of human infection. ..
  38. Enhancing Collectin-Mediated Defense Against Influenza
    Kevan Hartshorn; Fiscal Year: 2003
    ..abstract_text> ..
  39. TRANSCRIPTOME OF METASTATIC PROSTATE CANCER
    Gennadi Glinsky; Fiscal Year: 2001
    ..Subsequently the expression profile of these protein products will be studied in human prostate tumor samples by immunofluorescence analysis and immunohistochemistry to better correlate gene expression changes with phenotype. ..
  40. STRUCTURE/FUNCTIONS OF HUMAN TEAR LIPOPHILIN
    Robert Lehrer; Fiscal Year: 1999
    ..The long-term objectives for this research are to learn how lipophilin contributes to corneal and conjuctival health, and to explore its potential for creating new diagnostic and therapeutic modalities. ..
  41. Macromolecular X-ray Structure Facility Instrumentation
    Andrew Mesecar; Fiscal Year: 2003
    ....
  42. IL-6 IN HERPES SIMPLEX VIRUS TYPE 1 OCULAR REACTIVATION
    JOHN KRIESEL; Fiscal Year: 2002
    ..Novel and specific viral mutants will be constructed based on the results of HSV-DNA binding and transient expression assays. ..
  43. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2001
    ..This information will help elucidate how these important pathogens gain entry into, and spread between, cells, possibly identifying new anti-viral strategies for their control. ..
  44. A Molecular Basis for Phytoestrogen Chemoprevention
    Andrew Mesecar; Fiscal Year: 2002
    ..aid in the design of new compounds that can serve as selective estrogen modulators (SERMs). ..
  45. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2002
    ..This information will help elucidate how these important pathogens gain entry into, and spread between, cells, possibly identifying new anti-viral strategies for their control. ..
  46. Enhancing Collectin-Mediated Defense Against Influenza
    Kevan Hartshorn; Fiscal Year: 2002
    ..abstract_text> ..
  47. ALPHA HELICAL CATHELICIDINS AND HOST DEFENSE
    Robert Lehrer; Fiscal Year: 2002
    ..The experiments will expand our knowledge about these important peptides, and should provide the information needed to develop them as antibiotics for topical bronchopulmonary use in cystic fibrosis. ..
  48. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2003
    ..This information will help elucidate how these important pathogens gain entry into, and spread between, cells, possibly identifying new anti-viral strategies for their control. ..
  49. TRANSCRIPTOME OF METASTATIC PROSTATE CANCER
    Gennadi Glinsky; Fiscal Year: 2003
    ..Subsequently the expression profile of these protein products will be studied in human prostate tumor samples by immunofluorescence analysis and immunohistochemistry to better correlate gene expression changes with phenotype. ..
  50. ALPHA HELICAL CATHELICIDINS AND HOST DEFENSE
    Robert Lehrer; Fiscal Year: 1999
    ..The experiments will expand our knowledge about these important peptides, and should provide the information needed to develop them as antibiotics for topical bronchopulmonary use in cystic fibrosis. ..
  51. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 1999
    ..These experiments should yield important insights into basic collection biology and demonstrate that enhancement of collectin-mediated pulmonary host defense can be achieved in vivo through rational alteration of wild type collectins. ..
  52. TRANSCRIPTOME OF METASTATIC PROSTATE CANCER
    Gennadi Glinsky; Fiscal Year: 2004
    ..Subsequently the expression profile of these protein products will be studied in human prostate tumor samples by immunofluorescence analysis and immunohistochemistry to better correlate gene expression changes with phenotype. ..
  53. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Bruno Sainz; Fiscal Year: 2004
    ..The goal of the studies proposed herein is to elucidate the mechanism(s) by which IFN-beta and IFN-gamma inhibit HSV-1 replication and to identify the cellular factors that are involved in this process. ..
  54. Hantavirus genetics and respiratory cell interactions
    Andrew Pekosz; Fiscal Year: 2003
    ..The proposed studies will serve to advance our knowledge of HPS pathogenesis as well as lay the groundwork for the rational design of HPS vaccines and therapies. ..
  55. Isolation of Autoantibodies to Apoptotic Cells
    Marko Radic; Fiscal Year: 2004
    ..The results of these studies will allow a fuller assessment of the role of apoptotic cells in the induction of B cell tolerance or autoimmunity. ..
  56. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2004
    ..This information will help elucidate how these important pathogens gain entry into, and spread between, cells, possibly identifying new anti-viral strategies for their control. ..
  57. Enhancing Collectin-Mediated Defense Against Influenza
    Kevan Hartshorn; Fiscal Year: 2004
    ..abstract_text> ..
  58. Influenza virus assembly and virulence
    Andrew Pekosz; Fiscal Year: 2003
    ..abstract_text> ..
  59. STRUCTURE/FUNCTIONS OF HUMAN TEAR LIPOPHILIN
    Robert Lehrer; Fiscal Year: 2000
    ..The long-term objectives for this research are to learn how lipophilin contributes to corneal and conjuctival health, and to explore its potential for creating new diagnostic and therapeutic modalities. ..
  60. Collectin-Mediated Defense Against Influenza
    Kevan L Hartshorn; Fiscal Year: 2010
    ..These studies should elucidate important aspectsof defense against IAV and be relevant to treatment and prevention strategies. ..
  61. ALTRUINS, NATURAL ANTIBIOTICS OF THE MALE GENITAL TRACT
    Robert Lehrer; Fiscal Year: 2001
    ..S. are sexually transmitted. According to CDC estimates, STDs other than AIDS add 10 billion dollars to the nation's annual health care I costs. The proposed studies could lead to novel approaches for STD prophylaxis. ..
  62. Influenza virus assembly and virulence
    Andrew Pekosz; Fiscal Year: 2007
    ..abstract_text> ..
  63. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  64. Collectin-Mediated Defense Against Influenza
    Kevan Hartshorn; Fiscal Year: 2008
    ..These studies should elucidate important aspectsof defense against IAV and be relevant to treatment and prevention strategies. ..
  65. 4th International Conference on Oncolytic Viruses as Cancer Therapeutics
    Kah Whye Peng; Fiscal Year: 2007
    ..This provides an important training ground for tomorrow's scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
  66. Enhancing Collectin-Mediated Defense Against Influenza
    Kevan Hartshorn; Fiscal Year: 2005
    ..abstract_text> ..
  67. Theta-defensins Novel HIV-1 Uptake Inhibitors
    Robert Lehrer; Fiscal Year: 2007
    ..Specific Aim 2 will be realized by a combination of microchemical techniques, including surface plasmon resonance, tandem mass spectrometry, and state-of-the-art lectinomic and peptidomic chemistry. ..
  68. Collectin-Mediated Defense Against Influenza
    Kevan Hartshorn; Fiscal Year: 2007
    ..These studies should elucidate important aspects of defense against IAV and be relevant to treatment and prevention strategies. [unreadable] [unreadable] [unreadable]..
  69. Biacore 3000 SPR Instrument
    Robert Lehrer; Fiscal Year: 2004
    ..These include the development of new agents and approaches to prevent and treat infections caused by HIV-1 and other viral pathogens, and fundamental issues related to cell targeting and survival. ..
  70. Small Molecule X-Ray Diffraction Instrumentation
    Andrew Mesecar; Fiscal Year: 2002
    ..abstract_text> ..
  71. ALTRUINS, NATURAL ANTIBIOTICS OF THE MALE GENITAL TRACT
    Robert Lehrer; Fiscal Year: 1999
    ..S. are sexually transmitted. According to CDC estimates, STDs other than AIDS add 10 billion dollars to the nation's annual health care I costs. The proposed studies could lead to novel approaches for STD prophylaxis. ..
  72. Collectin-Mediated Defense Against Influenza
    Kevan Hartshorn; Fiscal Year: 2006
    ..These studies should elucidate important aspects of defense against IAV and be relevant to treatment and prevention strategies. [unreadable] [unreadable] [unreadable]..
  73. ALTRUINS, NATURAL ANTIBIOTICS OF THE MALE GENITAL TRACT
    Robert Lehrer; Fiscal Year: 2000
    ..S. are sexually transmitted. According to CDC estimates, STDs other than AIDS add 10 billion dollars to the nation's annual health care I costs. The proposed studies could lead to novel approaches for STD prophylaxis. ..
  74. High Throughput Screening-Based Identification of Measles Virus Probes
    RICHARD PLEMPER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  75. ALPHA HELICAL CATHELICIDINS AND HOST DEFENSE
    Robert Lehrer; Fiscal Year: 2003
    ..The experiments will expand our knowledge about these important peptides, and should provide the information needed to develop them as antibiotics for topical bronchopulmonary use in cystic fibrosis. ..
  76. Novel Organophosphorous Hydrolases for Decontamination
    Andrew Mesecar; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  77. Structural and Functional Study of Influenza Virus Hemagglutinin
    Qinghua Wang; Fiscal Year: 2009
    ....
  78. Cell culture animal models for SARS-CoV
    Andrew Pekosz; Fiscal Year: 2005
    ..Successful completion of the aims outlined in this application will establish systems for investigating the cell biology and pathogenesis of SARS-CoV. ..
  79. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  80. Enhancing localization of therapeutic viruses and cells to tumor sites
    Kah Whye Peng; Fiscal Year: 2009
    ..This grant seeks to improve the tumor localization of measles viruses and virus infected cell carriers by adding vascular binding motifs on their surfaces to enhance their attachment/arrest at tumor neovessels and tumor sites. ..