hepatitis delta antigens

Summary

Summary: Antigens produced by various strains of HEPATITIS D VIRUS.

Top Publications

  1. pmc The conserved serine 177 in the delta antigen of hepatitis delta virus is one putative phosphorylation site and is required for efficient viral RNA replication
    J J Mu
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 75:9087-95. 2001
  2. ncbi Hepatitis delta virus
    John M Taylor
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Virology 344:71-6. 2006
  3. ncbi RNA editing in hepatitis delta virus
    J L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA
    Curr Top Microbiol Immunol 307:67-89. 2006
  4. pmc Genotype-specific complementation of hepatitis delta virus RNA replication by hepatitis delta antigen
    J L Casey
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20852, USA
    J Virol 72:2806-14. 1998
  5. pmc Hepatitis delta virus ribonucleoproteins shuttle between the nucleus and the cytoplasm
    João P Tavanez
    Institute of Histology and Embryology, Faculty of Medicine, University of Lisbon, Portugal
    RNA 8:637-46. 2002
  6. pmc Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex
    Y P Xia
    Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033 1054
    J Virol 66:914-21. 1992
  7. pmc Transcription of hepatitis delta virus RNA by RNA polymerase II
    Jinhong Chang
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:1118-27. 2008
  8. pmc Combined proteomic-RNAi screen for host factors involved in human hepatitis delta virus replication
    Dan Cao
    RNA 15:1971-9. 2009
  9. pmc Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus
    Yun Hsin Wang
    Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, No 1, Jen Ai Road, First Section, Taipei 100, Taiwan
    J Virol 79:8113-20. 2005
  10. ncbi HDV RNA replication: ancient relic or primer?
    T B Macnaughton
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Curr Top Microbiol Immunol 307:25-45. 2006

Research Grants

  1. DELTA HEPATITIS AND LIVER DISEASE IN HEMOPHILIACS
    F Hollinger; Fiscal Year: 1990
  2. HDV RNA Folding and PKR Protein Regulation
    PHILIP BEVILACQUA; Fiscal Year: 2005
  3. HDV RNA Folding and PKR Protein Regulation
    PHILIP BEVILACQUA; Fiscal Year: 2007
  4. HDV RNA Folding and PKR Protein Regulation
    PHILIP BEVILACQUA; Fiscal Year: 2006
  5. HDV RNA Folding and PKR Protein Regulation
    PHILIP BEVILACQUA; Fiscal Year: 2004
  6. Mechanism and Regulation of RNA Polymerase II Elongation
    Zachary Burton; Fiscal Year: 2006
  7. Mechanism and Regulation of RNA Polymerase II Elongation
    Zachary Burton; Fiscal Year: 2005
  8. Mechanism and Regulation of RNA Polymerase II Elongation
    Zachary Burton; Fiscal Year: 2007
  9. Mechanism and Regulation of RNA Polymerase II Elongation
    Zachary Burton; Fiscal Year: 2004
  10. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2000

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. pmc The conserved serine 177 in the delta antigen of hepatitis delta virus is one putative phosphorylation site and is required for efficient viral RNA replication
    J J Mu
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 75:9087-95. 2001
    ..These results suggested that phosphorylation of S-HDAg, with serine 177 as a presumable site, plays a critical role in viral RNA replication, especially in augmenting the replication of antigenomic RNA...
  2. ncbi Hepatitis delta virus
    John M Taylor
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Virology 344:71-6. 2006
    ..It starts with a brief overview of HDV and its replication, notes some of the major unresolved questions, and directs the interested reader to more detailed reviews...
  3. ncbi RNA editing in hepatitis delta virus
    J L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA
    Curr Top Microbiol Immunol 307:67-89. 2006
    ..This review covers the mechanisms of RNA editing in the HDV replication cycle and the regulatory mechanisms by which HDV controls editing...
  4. pmc Genotype-specific complementation of hepatitis delta virus RNA replication by hepatitis delta antigen
    J L Casey
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20852, USA
    J Virol 72:2806-14. 1998
    ..e., HDV-I and HDV-III) rather than genotypes...
  5. pmc Hepatitis delta virus ribonucleoproteins shuttle between the nucleus and the cytoplasm
    João P Tavanez
    Institute of Histology and Embryology, Faculty of Medicine, University of Lisbon, Portugal
    RNA 8:637-46. 2002
    ..This suggests that HDV RNA mediates export of viral particles to the cytoplasm whereas the delta antigen triggers their reimport into the nucleus...
  6. pmc Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex
    Y P Xia
    Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033 1054
    J Virol 66:914-21. 1992
    ..Thus, our results indicate that HDAg forms aggregates in the cytoplasm and that the HDAg oligomerization is probably mediated by the leucine zipper sequence. Therefore, HDAg is likely transported into the nucleus as a protein complex...
  7. pmc Transcription of hepatitis delta virus RNA by RNA polymerase II
    Jinhong Chang
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:1118-27. 2008
    ..Findings include evidence that HDV replication is somehow able to direct the available delta antigen to sites in the nucleoplasm, almost exclusively colocalized with Pol II in what others have described as transcription factories...
  8. pmc Combined proteomic-RNAi screen for host factors involved in human hepatitis delta virus replication
    Dan Cao
    RNA 15:1971-9. 2009
    ..its RNA genome using a host polymerase because its only virally encoded proteins, the small and large hepatitis delta antigens (HDAg-S and HDAg-L), lack polymerase activity...
  9. pmc Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus
    Yun Hsin Wang
    Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, No 1, Jen Ai Road, First Section, Taipei 100, Taiwan
    J Virol 79:8113-20. 2005
    ..These data indicate a critical role of NESI in the assembly of HDV through interaction with HDAg-L...
  10. ncbi HDV RNA replication: ancient relic or primer?
    T B Macnaughton
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Curr Top Microbiol Immunol 307:25-45. 2006
    ..The ability of mammalian cells to replicate HDV RNA implies that RNA-dependent RNA synthesis was preserved throughout evolution...
  11. ncbi Characterization of the nuclear localization signal of the hepatitis delta virus antigen
    Carolina Alves
    Unidade de Biologia Molecular, Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 96 1349 008 Lisboa, Portugal
    Virology 370:12-21. 2008
    ..Deletion and mutation analysis of this region showed that both the acidic glutamic acid residue at position 66 and the basic arginine residue at position 75 are essential for promoting nuclear import...
  12. pmc Hepatitis delta virus antigen is methylated at arginine residues, and methylation regulates subcellular localization and RNA replication
    YI JIA LI
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Ave, Los Angeles, CA 90033 1054, USA
    J Virol 78:13325-34. 2004
    ....
  13. pmc ERK1/2-mediated phosphorylation of small hepatitis delta antigen at serine 177 enhances hepatitis delta virus antigenomic RNA replication
    Yen Shun Chen
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 82:9345-58. 2008
    ..These results demonstrate the role of ERK1/2-mediated Ser-177 phosphorylation in modulating HDV antigenomic RNA replication, possibly through RNAPII regulation. The results may shed light on the mechanisms of HDV RNA replication...
  14. ncbi Large hepatitis delta antigen modulates transforming growth factor-beta signaling cascades: implication of hepatitis delta virus-induced liver fibrosis
    Soo Ho Choi
    Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang 431 060, Korea
    Gastroenterology 132:343-57. 2007
    ....
  15. pmc By inhibiting replication, the large hepatitis delta antigen can indirectly regulate amber/W editing and its own expression
    Shuji Sato
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111 1817, USA
    J Virol 78:8120-34. 2004
    ..In addition, the structure adjacent to the amber/W site is suboptimal for editing, and this creates a window of time in which replication can occur in the absence of HDAg-L...
  16. ncbi Induction of hepatitis D virus large antigen translocation to the cytoplasm by hepatitis B virus surface antigens correlates with endoplasmic reticulum stress and NF-kappaB activation
    I Cheng Huang
    Department of Microbiology and Immunology, Chang Gung University, Tao Yuan, Taiwan 333, Republic of China
    J Gen Virol 87:1715-23. 2006
    ..Nevertheless, TNF-alpha-induced GFP-LD translocation was independent of new protein synthesis, suggesting that a post-translational event occurs to GFP-LD to allow translocation...
  17. ncbi The double-stranded RNA-activated kinase, PKR, can phosphorylate hepatitis D virus small delta antigen at functional serine and threonine residues
    Chi Wu Chen
    Graduate Institute of Microbiology and Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biol Chem 277:33058-67. 2002
    ..Other than human immunodeficiency virus type 1 trans-activating protein (Tat), S-HDAg is another viral protein phosphorylated by PKR that may regulates HDV replication and viral response to interferon therapy...
  18. ncbi The small delta antigen of hepatitis delta virus is an acetylated protein and acetylation of lysine 72 may influence its cellular localization and viral RNA synthesis
    Jung Jung Mu
    Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Virology 319:60-70. 2004
    ..These results demonstrated that HDAg is an acetylated protein and mutation of HDAg at Lys-72 modulates HDAg subcellular localization and may participate in viral RNA nucleocytoplasmic shuttling and replication...
  19. pmc Transcription factor YY1 and its associated acetyltransferases CBP and p300 interact with hepatitis delta antigens and modulate hepatitis delta virus RNA replication
    Wen Hung Huang
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan 112, Republic of China
    J Virol 82:7313-24. 2008
    ..All together, our results reveal that HDAg interacts with cellular transcription factor YY1 and its associated acetyltransferases CBP and p300 in a large nuclear complex, which in turn modulates the replication of HDV RNA...
  20. pmc Large hepatitis delta antigen is a novel clathrin adaptor-like protein
    Cheng Huang
    Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, No 1, Jen Ai Road, First Section, Taipei, Taiwan
    J Virol 81:5985-94. 2007
    ..These results indicate that HDAg-L is a new clathrin adaptor-like protein, and it may be involved in the maturation and pathogenesis of HDV coinfection or superinfection with hepatitis B virus through interaction with clathrin...
  21. ncbi A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution
    R Brazas
    Department of Microbiology, University of California, San Francisco, CA 94143, USA
    Science 274:90-4. 1996
    ..These observations demonstrate that a host gene product can modulate HDV replication and suggest that HDV may have evolved from a primitive viroidlike RNA through capture of a cellular transcript...
  22. ncbi A novel chromosome region maintenance 1-independent nuclear export signal of the large form of hepatitis delta antigen that is required for the viral assembly
    C H Lee
    Institute of Biochemistry, College of Medicine, National Taiwan University, No. 1, Jen-Ai Rd, First Section, Taipei, Taiwan
    J Biol Chem 276:8142-8. 2001
    ..Furthermore, assembly of HDV is insensitive to leptomycin B, indicating that the NES(HDAg-L) directs nuclear export of HDAg-L to the cytoplasm via a chromosome region maintenance 1-independent pathway...
  23. ncbi The HDV large-delta antigen fused with GFP remains functional and provides for studying its dynamic distribution
    K N Shih
    Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, 11221, ROC
    Virology 285:138-52. 2001
    ....
  24. ncbi Ser-123 of the large antigen of hepatitis delta virus modulates its cellular localization to the nucleolus, SC-35 speckles or the cytoplasm
    Keng Poo Tan
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan 112
    J Gen Virol 85:1685-94. 2004
    ..Thus, the current study demonstrated that both cis and trans elements modulate HDAg translocation to various subcellular sites...
  25. ncbi Stimulation of RNA polymerase II elongation by hepatitis delta antigen
    Y Yamaguchi
    Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226 8503, Japan
    Science 293:124-7. 2001
    ..These results suggest that HDAg may regulate RNAPII elongation during both cellular messenger RNA synthesis and HDV RNA replication...
  26. ncbi The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication
    W H Huang
    Institute of Biochemistry and Institute of Microbiology and Immunology, National Yang-Ming University, Taipei 112, Taiwan, Republic of China
    J Biol Chem 276:25166-75. 2001
    ..Therefore, this work demonstrates the important role of nucleolar protein in regulating the HDV RNA replication through the complex formation with the key positive regulator being small HDAg...
  27. ncbi Hepatitis delta virus genetic variability: from genotypes I, II, III to eight major clades?
    P Deny
    Service de Bacteriologie, Virologie, Hygiene, Laboratoire Associé au Centre National de Référence des Hépatites B et C, Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris 13, Bobigny, France
    Curr Top Microbiol Immunol 307:151-71. 2006
    ..These results bring the geographic distribution of HDV closer to the genetic variability of its helper HBV...
  28. pmc A hepatitis B surface antigen mutant that lacks the antigenic loop region can self-assemble and interact with the large hepatitis delta antigen
    Brendan O'Malley
    Department of Molecular Biology and Microbiology and The Raymond and Beverly Sackler Research Foundation Laboratory, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Virol 76:10060-3. 2002
    ..Although the mutant protein was competent for interaction with and incorporation of free large hepatitis delta antigen, it was partially defective in hepatitis delta virus RNP incorporation...
  29. pmc Transcription of subgenomic mRNA of hepatitis delta virus requires a modified hepatitis delta antigen that is distinct from antigenomic RNA synthesis
    Chung Hsin Tseng
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    J Virol 82:9409-16. 2008
    ..We propose that acetylation and deacetylation of HDAg may provide a molecular switch for the synthesis of the different HDV RNA species...
  30. ncbi Development and characterisation of recombinant hepatitis delta virus-like particles
    S M Ward
    Clinical Medical Virology Centre, The University of Queensland, St Lucia, Australia
    Virus Genes 23:97-104. 2001
    ..2 g/cm3 in caesium chloride and approximately 1.15 g/cm3 in sucrose. The VLPs were also immunoprecipitated using an anti-HBs but not an anti-HD antibody. Thus, these recombinant VLPs have similar biophysical properties to L-HDAg VLPs...
  31. ncbi Hepatitis D virus RNA editing is inhibited by a GFP fusion protein containing a C-terminally deleted delta antigen
    Ko Nien Shih
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan 112
    J Gen Virol 85:947-57. 2004
    ..In situ hybridization showing co-localization of HDV RNA with D(1-88)-GFP at nuclear speckles suggested that HDV RNA editing might occur in the nuclear speckles and require other nuclear factor(s), in addition to ADAR...
  32. pmc Resistance of human hepatitis delta virus RNAs to dicer activity
    Jinhong Chang
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
    J Virol 77:11910-7. 2003
    ..Apparently, for unit-length RNAs of HDV, PSTVd, and ASBVd, it is the extended structure with <100% base pairing that confers significant resistance to dicer action...
  33. ncbi [Detection of HDV antigen and antibody]
    Osami Inoue
    Digestive Organ Department, Nagasaki Labour Welfare Hospital
    Nihon Rinsho 62:412-5. 2004
  34. ncbi [Test for specific antibodies to virus hepatitis delta based on synthetic peptides]
    Iu A Semiletov
    Vopr Virusol 47:21-4. 2002
    ..Analysis of obtained data showed that these peptides can be used in new diagnostic anti-HDV tests...
  35. pmc Interaction and replication activation of genotype I and II hepatitis delta antigens
    Sheng Chieh Hsu
    Institutes of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Virol 78:2693-700. 2004
    ..In conclusion, genotype has no effect on HDAg interaction and genotype per se only partly predicts how much the HDAg-S of an HDV isolate affects the replication of a second HDV isolate...
  36. ncbi How did replicating and coding RNAs first get together?
    H D Robertson
    Department of Biochemistry, New York Hospital Cornell Medical Center, New York, New York 10021, USA
    Science 274:66-7. 1996
  37. ncbi Anti-hepatitis delta virus seroprevalence and risk factors in patients with hepatitis B in Southeast Turkey
    Mustafa K Celen
    Dicle Universitesi Hastanesi, Klinik Mikrobiyoloji ve Enfeksiyon Hastaliklari Anabilim Dali, 21280, Diyarbakir, Turkey
    Saudi Med J 27:617-20. 2006
    ....
  38. ncbi [Replication of hepatitis delta virus]
    Tetsuro Suzuki
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 62:393-7. 2004
  39. ncbi Natural history of compensated viral B and D cirrhosis
    Liana Gheorghe
    Hepatology Unit, Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Str Fundeni no 258, 72437 Bucharest, Romania
    Rom J Gastroenterol 14:329-35. 2005
    ..The aim of this study was to define the natural long-term course of HDV compensated cirrhosis...
  40. doi Hepatitis D virus: an update
    Stéphanie Pascarella
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Liver Int 31:7-21. 2011
    ..Treatment involves the administration of pegylated interferon-α and is effective in only about 20% of patients. Liver transplantation is indicated in case of liver failure...
  41. ncbi Vaccination against hepatitis delta virus infection: studies in the woodchuck (Marmota monax) model
    M Fiedler
    Institute of Virology, Universitatsklinikum Essen, Germany
    Intervirology 44:154-61. 2001
    ..Thus, new strategies to develop a vaccine to prevent HDV superinfection are needed...
  42. pmc Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex
    Takashi Narita
    Graduate School of Bioscience and Biotechnolog, Tokyo Institute of Technology, 4259 Nagatsuka, Yokohama 226 8503, Japan
    Mol Cell Biol 23:1863-73. 2003
    ..This study defines several important protein-protein interactions and opens the way for understanding the mechanism of DSIF- and NELF-induced transcriptional pausing...
  43. doi Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma cells
    Fu Tien Liao
    Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    J Gen Virol 90:1124-34. 2009
    ..These data indicated that HDV-induced clusterin protein increases cell survival potential. Thus, it is possible that epigenetic regulation by HDV contributes to a pathological outcome of hepatitis D/hepatitis B viral hepatitis and HCC...
  44. pmc Genetic changes in hepatitis delta virus from acutely and chronically infected woodchucks
    John L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007, USA
    J Virol 80:6469-77. 2006
    ..Chronic HDV infection in woodchucks may result from a delayed and weak immune response that is limited to a small number of epitopes on HDAg...
  45. ncbi Hepatitis delta virus infection in chronically HBV-infected patients from northern Poland
    K P Bielawski
    Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland
    Arch Virol 151:1207-15. 2006
    ..Two RNA-positive/anti-HD-negative samples possessed a few uncommon nucleotide substitution sites within the L-HDAg sequence, which could suggest unique variants in the Polish population of HDV-infected patients...
  46. pmc Clinical and histological features of delta infection in chronic hepatitis B virus carriers
    A S Lok
    J Clin Pathol 38:530-3. 1985
    ..Delta infection in chronic HBV carriers is associated with a more active and progressive liver disease...
  47. ncbi Molecular cloning and sequencing of a human hepatitis delta (delta) virus RNA
    S Makino
    Nature 329:343-6. 1987
    ..Five open reading frames (ORFs) of more than 100 amino acids in both genomic and anti-genomic sense were found. The largest ORF in antigenomic sense, which can code for 214 amino acids, may correspond to the HDAg...
  48. ncbi [Hepatitis D]
    José Carlos Ferraz da Fonseca
    Fundação de Medicina Tropical, Manaus, AM, 69040 000, Brasil
    Rev Soc Bras Med Trop 35:181-90. 2002
    ..Orthotopic liver transplantation is indicated for terminal cases of cirrhosis. Prophylaxis for HDV infection is possible by vaccination against the hepatitis B virus...
  49. ncbi A case of quadruple viral infections and elevated aminotransferase activities
    Devina Bhasin
    Division of Liver Diseases and Recanati Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Semin Liver Dis 32:262-6. 2012
    ..HDV infection should be considered in patients with known chronic viral hepatitis B with low viral load, who present with worsening liver function or elevation in aminotransferase activities...
  50. pmc A tryptophan-rich motif in the carboxyl terminus of the small envelope protein of hepatitis B virus is central to the assembly of hepatitis delta virus particles
    Isabelle Komla-Soukha
    Laboratoire de Virologie, Institut National de la Transfusion Sanguine, 6 rue Alexandre Cabanel, 75739, Paris, France
    J Virol 80:4648-55. 2006
    ....
  51. doi Lysine-71 in the large delta antigen of hepatitis delta virus clade 3 modulates its localization and secretion
    Chi Ruei Huang
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei 112, Taiwan, ROC
    Virus Res 170:75-84. 2012
    ..Combined, our observations support the hypothesis that the acetylation status of LDAg-3 plays a role in regulating LDAg-3's localization inside the nucleus or cytoplasm, and its secretion...
  52. pmc Phylogenetic analysis of HDV isolates from HBsAg positive patients in Karachi, Pakistan
    Shadab Perveen
    The Karachi Institute of Biotechnology and Genetic Engineering KIBGE, University of Karachi, Karachi, Pakistan
    Virol J 9:162. 2012
    ..The aim of this study is to analyze the genetic proximity within local HDV strains, and relationship with other clades of HDV, using phylogenetic analysis...
  53. pmc New enzyme-linked immunosorbent assay for detection of antibodies against hepatitis delta virus using a hepatitis delta antigen derived from a Taiwanese clone and comparison to the Abbott radioimmunoassay
    Yung Bin Kuo
    Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Clin Vaccine Immunol 19:817-9. 2012
    ..The detection efficiency of this assay was comparable to that of the commercially available Abbott anti-HD radioimmunoassay (RIA) and could be useful in routine laboratory diagnoses of HDV infection...
  54. doi An update on HDV: virology, pathogenesis and treatment
    Mónica V Alvarado-Mora
    Laboratory of Tropical Gastroenterology and Hepatology João Alves de Queiroz and Castorina Bittencourt Alves, Institute of Tropical Medicine, Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Antivir Ther 18:541-8. 2013
    ..Current treatments include pegylated interferon-α and liver transplantation; the latter of which can be curative. Further studies are needed to develop better treatment strategies for this challenging disease. ..
  55. ncbi [Gene optimization, protein expression, purification and characterization of the HDV antigen for diagnosis]
    Jun Ying Ding
    National Institute for Viral Disease Control and Prevention, Beijng 102206, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 26:87-9. 2012
    ..To prepare HDAg with biological activities as a candidate of diagnostic reagent...
  56. doi Large hepatitis delta antigen activates STAT-3 and NF-κB via oxidative stress
    V Williams
    Service de Bacteriologie, virologie hygiène, Hopital Avicenne, Assistance Publique des Hopitaux de Paris, Laboratoire Associé au Centre National de Référence des Hépatites B, C et delta, Universite Paris Nord, Paris
    J Viral Hepat 19:744-53. 2012
    ..These results provide insight into the mechanisms by which p27 can alter intracellular events relevant to HDV-related liver pathogenesis...
  57. ncbi Structural basis of the oligomerization of hepatitis delta antigen
    H J Zuccola
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Structure 6:821-30. 1998
    ..It is believed that HDAg forms dimers and higher ordered structures through this coiled-coil region...
  58. ncbi "Defective" mutations of hepatitis D viruses in chronic hepatitis D patients
    Jaw Ching Wu
    Institute of Clinical Medicine, National Yang Ming University, Taipei 112, Taiwan, China
    World J Gastroenterol 11:1658-62. 2005
    ..To verify whether "defective" mutations existed in hepatitis D virus (HDV)...
  59. ncbi Seroprevalence of antibody to HDV in Nigerians with hepatitis B virus-related liver diseases
    S C Nwokediuko
    Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria
    Niger J Clin Pract 12:439-42. 2009
    ..In order to ascertain the current status of HDV infection in Nigeria, a study of patients with hepatitis B virus (HBV)-related liver diseases was undertaken to determine the sero-prevalence ofanti-HDV...
  60. ncbi NTP-driven translocation by human RNA polymerase II
    Yuri A Nedialkov
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1319, Japan
    J Biol Chem 278:18303-12. 2003
    ....
  61. ncbi Delta-interacting protein A and the origin of hepatitis delta antigen
    M Long
    Science 276:824-5. 1997
  62. ncbi Baculovirus as a highly efficient gene delivery vector for the expression of hepatitis delta virus antigens in mammalian cells
    Kuei Chun Wang
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan
    Biotechnol Bioeng 89:464-73. 2005
    ..Baculovirus can also be envisaged as a useful tool for investigating protein-cell interactions and virus assembly...
  63. doi Seroprevalence of hepatitis delta virus infection among subjects with underlying hepatic diseases in Chennai, southern India
    Shanmugam Saravanan
    Indian Council of Medical Research Referral Centre for Chronic Hepatitis and Molecular Virology, Department of Microbiology, University of Madras, Chennai 600 113, India
    Trans R Soc Trop Med Hyg 102:793-6. 2008
    ..6%), compared with previous Indian reports varying from 10.7% to >30%. HDV infection was relatively low and seems to play a minor determining factor of liver diseases in the tropical south Indian population...
  64. ncbi Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity
    Yuki Yamaguchi
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226 8501, Japan
    Genes Cells 12:863-75. 2007
    ..By reducing transcriptional fidelity in terms of not only discrimination of incoming nucleotides but also recognition of templates, HDAg may facilitate the unusual RNA-dependent RNA synthesis by Pol II...
  65. doi Hepatitis Delta virus genotype 8 infection in Northeast Brazil: inheritance from African slaves?
    L M F Barros
    Hospital Universitário da Universidade Federal do Maranhão, Sao Luis, Maranhao, Brazil
    Virus Res 160:333-9. 2011
    ..Our results indicate that the need of clinical and epidemiological studies to investigate the presence of this infection in other areas in Brazil...
  66. pmc Multimerization of hepatitis delta antigen is a critical determinant of RNA binding specificity
    Brian C Lin
    Department of Microbiology and Immunology, Georgetown University Medical Center, 3900 Reservoir Rd, NW, Washington, DC 20007, USA
    J Virol 84:1406-13. 2010
    ..The results confirm the previous proposal that HDAg binds as a large multimer and demonstrate that the multimer is a critical determinant of the structure of the HDV RNP...
  67. pmc Roles of carboxyl-terminal and farnesylated residues in the functions of the large hepatitis delta antigen
    Brendan O'Malley
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Ave, Boston, MA 02111, USA
    J Virol 79:1142-53. 2005
    ....
  68. pmc Positive selection of hepatitis delta antigen in chronic hepatitis D patients
    Shen Yung Wang
    Department of Medical Research and Education, Taipei Veterans General Hospital, 201 Shih Pai Road, Sec 2, Taipei 11217, Taiwan
    J Virol 81:4438-44. 2007
    ..The discovery of immunogenic epitopes, especially cytotoxic-T-lymphocyte ligands, associated with chronic HDV infection may be crucial for further development of novel treatments or designs in vaccine for HDV superinfection...
  69. doi Complete genome sequences and phylogenetic analysis of hepatitis delta viruses isolated from nine Turkish patients
    Inci Celik
    Department of Gastroenterology, Institute of Hepatology, School of Medicine, Ankara University, Cebeci, Turkey
    Arch Virol 156:2215-20. 2011
    ..8% (between the Turkish isolates and HDV-1). The lowest sequence similarity is 56.4% (between the Turkish isolates and HDV-3). In conclusion, phylogenetic analysis shows that the Turkish HDV isolates belong to HDV-1...
  70. pmc Intracellular localization of hepatitis delta virus proteins in the presence and absence of viral RNA accumulation
    Ziying Han
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 83:6457-63. 2009
    ..These studies provide evidence that deltaAg does not interact directly with either Pol II or nucleolin and that forms of deltaAg which support replication are also capable of prior nucleolar transit...
  71. ncbi Virological and histological re-evaluation of Labrea hepatitis
    Raymundo Parana
    Gastro Hepatology Unit, Federal University of Bahia, Brazil
    Acta Gastroenterol Latinoam 38:284-90. 2008
    ..a peculiar form of fulminant hepatitis known as Labrea hepatitis, probably related to hepatitis B and D, has been reported in Brazilian Amazon as early as the 1930s...
  72. pmc Efficient expression of histidine-tagged large hepatitis delta antigen in baculovirus-transduced baby hamster kidney cells
    Ying Wei Chiang
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan, China
    World J Gastroenterol 12:1551-7. 2006
    ..To study the baculovirus/mammalian cell system for efficient expression of functional large hepatitis delta antigen (L-HDAg)...
  73. pmc In Vivo Interaction of the Hepatitis Delta Virus Small Antigen with the ELAV-Like Protein HuR
    Ana Casaca
    Unidade de Biologia Molecular, Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa Rua da Junqueira 100, 1349 008 Lisboa, Portugal
    Open Virol J 5:12-21. 2011
    ..HuR was found to be overexpressed and colocalize with HDAg in human hepatoma cells. siRNA knockdown of HuR mRNA resulted in inhibition of S-HDAg and L-HDAg expression...
  74. doi Pro-205 of large hepatitis delta antigen and Pro-62 of major hepatitis B surface antigen influence the assembly of different genotypes of hepatitis D virus
    Hsuan Hui Shih
    Department of Medical Research and Education, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Gen Virol 91:1004-12. 2010
    ..The presence of Pro-205 in genotype 1 HDV may account for its higher assembly efficiencies and wider distribution...
  75. ncbi Hepatitis D antigens cause growth retardation and brood-size reduction in C. elegans
    Li Wei Lee
    Department of Life Science, Chang Gung University, Tao Yuan, Taiwan
    Front Biosci (Elite Ed) 3:380-90. 2011
    ..Heat-shock induction of HDAg expression revealed that L4 larvae were the most sensitive to brood size reduction. These studies demonstrate that C. elegans can provide an additional model for studying HDAg interactions with host targets...
  76. pmc Properties of subviral particles of hepatitis B virus
    Ning Chai
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    J Virol 82:7812-7. 2008
    ..However, unlike soluble forms of HBV envelope protein that were potent inhibitors, the SVP did not inhibit the ability of HBV and HDV to infect primary human hepatocytes...
  77. ncbi Prenylation of HDAg and antiviral drug development
    J S Glenn
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, CA 94305 5187, USA
    Curr Top Microbiol Immunol 307:133-49. 2006
    ..These agents represent a new class of antiviral agents, with HDV as a first target. Here, a brief review of the HDV life cycle emphasizing the role of prenylation is presented along with implications for drug development and therapy...
  78. pmc Varied immunity generated in mice by DNA vaccines with large and small hepatitis delta antigens
    Yi Hsiang Huang
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Virol 77:12980-5. 2003
    ..The role of the isoprenylated motif of hepatitis delta antigens (HDAg) in the generation of immune responses following DNA-based immunization has never been studied...
  79. ncbi Changes in the proteome of Huh7 cells induced by transient expression of hepatitis D virus RNA and antigens
    Sérgio Mota
    Unidade de Biologia Molecular, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
    J Proteomics 71:71-9. 2008
    ..Moreover, the down regulation of hnRNP D, HSP105, and triosephosphate isomerase was further confirmed by Real time PCR...
  80. pmc Crystallization and X-ray diffraction analysis of the Trp/amber editing site of hepatitis delta virus (+)RNA: a case of rational design
    Celeste MacElrevey
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:1049-53. 2005
    ..5, c = 63.5 A. The crystallization and X-ray analysis of multiple forms of the HDV RNA-editing substrate, encounters with common RNA crystal-growth defects and a strategy to overcome these problems are reported...
  81. ncbi [Hepatitis delta virus (HDV) virions, HDV-RNA and HDV related proteins]
    Tadashi Goto
    Department of Gastroenterology, JR Tokyo General Hospital
    Nihon Rinsho 62:389-92. 2004
  82. pmc Hepatitis delta virus minimal substrates competent for editing by ADAR1 and ADAR2
    S Sato
    Department of Molecular Biology and Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Virol 75:8547-55. 2001
    ..Hence, the HDV amber/W site represents the smallest ADAR substrate yet identified. In contrast, the minimal substrate competent for hADAR2-mediated editing contained 66 nucleotides...
  83. ncbi In vitro replication of hepatitis D virus using a new construct containing a cDNA dimer of HDV genome
    Farida Behzadian
    Department of Virology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Intervirology 50:387-93. 2007
    ..There is no cell line susceptible to hepatitis D virus (HDV) infection and capable of stable replication of its genome. Different genetic-based approaches have been introduced to initiate HDV replication events so far...
  84. pmc RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies
    YI JIA LI
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Ave, Los Angeles, CA 90033 1054, USA
    J Virol 80:6478-86. 2006
    ..These findings provide additional evidence that HDV RNA synthesis occurs in the Pol I and Pol II transcription machineries, thus extending the capability of the cellular DNA-dependent RNA polymerases to utilizing RNA as templates...
  85. pmc Control of ADAR1 editing of hepatitis delta virus RNAs
    John L Casey
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA
    Curr Top Microbiol Immunol 353:123-43. 2012
    ..This review will cover the mechanisms of editing at the amber/W site and the means by which the virus controls it in these two genotypes...
  86. ncbi [Short communication: evaluation of the correlation between hepatitis D virus (HDV) RNA positivity and HDV antibodies]
    Tuncer Ozekinci
    Dicle Universitesi Tip Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Diyarbakir
    Mikrobiyol Bul 39:345-9. 2005
    ....
  87. ncbi Initiation of hepatitis delta virus (HDV) replication: HDV RNA encoding the large delta antigen cannot replicate
    Gwo Tarng Sheu
    Institute of Toxicology, Chung Shan Medical University, 110 Sec 1, Chien Kuo N Road, Taichung 40203, Taiwan, Republic of China
    J Gen Virol 83:2507-13. 2002
    ..These results suggest that the genomic RNA species encoding S-HDAg is the only functional genome for HDV infection and explain why the presence of the edited HDV RNA encoding L-HDAg does not interfere with HDV infection...
  88. ncbi High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia
    Jun Inoue
    Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi ken, Japan
    J Med Virol 76:333-40. 2005
    ..The anti-HDV assay may be useful for further epidemiological studies on HDV infection in larger cohorts in urban and rural areas of Mongolia, where elucidation of the transmission route of HDV is required urgently...
  89. pmc RNA editing in hepatitis delta virus genotype III requires a branched double-hairpin RNA structure
    John L Casey
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
    J Virol 76:7385-97. 2002
    ..The different mechanisms of editing in genotypes I and III underscore their functional differences and may be related to pathogenic differences as well...
  90. pmc Determination of the multimerization state of the hepatitis delta virus antigens in vivo
    Cromwell T Cornillez-Ty
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Virol 77:10314-26. 2003
    ..Therefore, in vivo, the C terminus likely provides an additional site of protein-protein interaction for the large delta antigen...
  91. ncbi [Molecular switch for mRNA synthesis rate]
    Tadashi Wada
    Tanpakushitsu Kakusan Koso 48:9-17. 2003
  92. pmc Polyadenylation of the mRNA of hepatitis delta virus is dependent on the structure of the nascent RNA and regulated by the small or large delta antigen
    S Y Hsieh
    Department of Microbiology and Immunology, Chang Gung College of Medicine and Technology, Taipei, Taiwan
    Nucleic Acids Res 22:391-6. 1994
    ..We concluded that the HDV polyadenylation could be regulated by the structure of the nascent antigenomic RNA and by either the small or large HDAg...
  93. pmc Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2
    Geetha C Jayan
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20850, USA
    J Virol 76:3819-27. 2002
    ..Our results indicate that HDV requires highly regulated and selective editing and that the level of ADAR expression can play an important role: overexpression of ADARs inhibits HDV RNA replication and compromises virus viability...
  94. pmc Hepatitis delta antigen requires a minimum length of the hepatitis delta virus unbranched rod RNA structure for binding
    Dawn A Defenbaugh
    Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Virol 83:4548-56. 2009
    ..The results are consistent with a model in which HDAg binds HDV unbranched rod RNA as multimers of fixed size rather than as individual subunits...
  95. ncbi Cell cycle arrest mediated by hepatitis delta antigen
    S B Hwang
    Institute of Environment and Life Science, The Hallym Academy of Sciences, Hallym University, Chuncheon, South Korea
    FEBS Lett 449:41-4. 1999
    ..This phenomenon may be partly responsible for the persistent infection of chronic HDV patients...
  96. ncbi Functional and clinical significance of hepatitis D virus genotype II infection
    J C Wu
    Department of Medical Research and Education, Institute of Clinical Medicine, Taipei Veterans General Hospital, National Yang Ming University, Taiwan
    Curr Top Microbiol Immunol 307:173-86. 2006
    ..There is no genotypic or size restriction on the interactions of either the small or the large hepatitis delta antigens (HDAgs) between genotypes I and II, and there is also no genotypic incompatibility during co-package of ..
  97. ncbi Hepatitis delta virus large antigen sensitizes to TNF-alpha-induced NF-kappaB signaling
    Chul Yong Park
    Ilsong Institute of Life Science, Hallym University, Anyang 431 060, Korea
    Mol Cells 28:49-55. 2009
    ..Finally, we demonstrated that LHDAg augmented the COX-2 expression level in Huh7 cells. These data suggest that LHDAg modulates NF-kappaB signaling pathway and may contribute to HDV pathogenesis...
  98. ncbi HIV and hepatitis delta virus: evolution takes different paths to relieve blocks in transcriptional elongation
    Yuki Yamaguchi
    Graduate School of Bioscience and Biotechnology, 4259 Nagatsuta, Yokohama 226 8503, Japan
    Microbes Infect 4:1169-75. 2002
    ....
  99. pmc Intrinsic disorder and oligomerization of the hepatitis delta virus antigen
    Carolina Alves
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Virology 407:333-40. 2010
    ..Oligomers of purified δAg were resistant to elevated NaCl and urea concentrations, and bound without specificity to RNA and single- and double-stranded DNAs...
  100. pmc Clathrin-mediated post-Golgi membrane trafficking in the morphogenesis of hepatitis delta virus
    Cheng Huang
    Institute of Biochemistry and Molecular Biology, Institute of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Virol 83:12314-24. 2009
    ..Thus, the clathrin box and the nuclear export signal at the C terminus of HDAg-L are potential new molecular targets for HDV therapy...
  101. ncbi Induction of cytotoxic T lymphocyte responses against hepatitis delta virus antigens which protect against tumor formation in mice
    C Mauch
    Department of Medicine II, University Hospital Freiburg, Hugstetter Strasse 55, D-79106, Freiburg, Germany
    Vaccine 20:170-80. 2001
    ....

Research Grants51

  1. DELTA HEPATITIS AND LIVER DISEASE IN HEMOPHILIACS
    F Hollinger; Fiscal Year: 1990
    ..Finally, household members of hemophiliacs will be examined for evidence of HBV, HDV and NANB hepatitis infection in order to determine the risk of transmission of these agents in the home environment...
  2. HDV RNA Folding and PKR Protein Regulation
    PHILIP BEVILACQUA; Fiscal Year: 2005
    ..Results are expected to be of fundamental interest to the RNA folding community and may impact the understanding of RNA folding in other biologically relevant RNA and RNA-protein systems including catalytic RNAs and the ribosome. ..
  3. HDV RNA Folding and PKR Protein Regulation
    PHILIP BEVILACQUA; Fiscal Year: 2007
    ..Results are expected to be of fundamental interest to the RNA folding community and may impact the understanding of RNA folding in other biologically relevant RNA and RNA-protein systems including catalytic RNAs and the ribosome. ..
  4. HDV RNA Folding and PKR Protein Regulation
    PHILIP BEVILACQUA; Fiscal Year: 2006
    ..Results are expected to be of fundamental interest to the RNA folding community and may impact the understanding of RNA folding in other biologically relevant RNA and RNA-protein systems including catalytic RNAs and the ribosome. ..
  5. HDV RNA Folding and PKR Protein Regulation
    PHILIP BEVILACQUA; Fiscal Year: 2004
    ..Results are expected to be of fundamental interest to the RNA folding community and may impact the understanding of RNA folding in other biologically relevant RNA and RNA-protein systems including catalytic RNAs and the ribosome. ..
  6. Mechanism and Regulation of RNA Polymerase II Elongation
    Zachary Burton; Fiscal Year: 2006
    ..Kinetic analysis of human RNAP II gives novel insight into the mechanism and regulation of translocation, NTP loading, pyrophosphate release and the efficiency and fidelity of NMP incorporation. ..
  7. Mechanism and Regulation of RNA Polymerase II Elongation
    Zachary Burton; Fiscal Year: 2005
    ..Kinetic analysis of human RNAP II gives novel insight into the mechanism and regulation of translocation, NTP loading, pyrophosphate release and the efficiency and fidelity of NMP incorporation. ..
  8. Mechanism and Regulation of RNA Polymerase II Elongation
    Zachary Burton; Fiscal Year: 2007
    ..Kinetic analysis of human RNAP II gives novel insight into the mechanism and regulation of translocation, NTP loading, pyrophosphate release and the efficiency and fidelity of NMP incorporation. ..
  9. Mechanism and Regulation of RNA Polymerase II Elongation
    Zachary Burton; Fiscal Year: 2004
    ..Kinetic analysis of human RNAP II gives novel insight into the mechanism and regulation of translocation, NTP loading, pyrophosphate release and the efficiency and fidelity of NMP incorporation. ..
  10. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2000
    ..These aims will be addressed by a combination of approaches, including site- directed mutagenesis, analysis in vitro of editing and RNA-protein interactions, and evaluation of editing and its consequences in transfected cells. ..
  11. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2002
    ..These aims will be addressed by a combination of approaches, including site- directed mutagenesis, analysis in vitro of editing and RNA-protein interactions, and evaluation of editing and its consequences in transfected cells. ..
  12. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  14. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2005
    ....
  15. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2003
    ....
  16. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 1999
    ..These aims will be addressed by a combination of approaches, including site- directed mutagenesis, analysis in vitro of editing and RNA-protein interactions, and evaluation of editing and its consequences in transfected cells. ..
  17. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2004
    ....
  18. HEPATITIS DELTA VIRUS RNA EDITING
    John Casey; Fiscal Year: 2001
    ..These aims will be addressed by a combination of approaches, including site- directed mutagenesis, analysis in vitro of editing and RNA-protein interactions, and evaluation of editing and its consequences in transfected cells. ..
  19. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 1992
    ..The sequences will also be tested for relationship to those of the retrovirus-like particles, reportedly released from embryonic quail tissues, in the studies of Hofschneider and coworkers...
  20. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2001
    ....
  21. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2007
    ..abstract_text> ..
  22. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2004
    ..abstract_text> ..
  23. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2009
    ..abstract_text> ..
  24. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 1991
    ..The sequences will also be tested for relationship to those of the retrovirus-like particles, reportedly released from embryonic quail tissues, in the studies of Hofschneider and coworkers...
  25. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2006
    ..abstract_text> ..
  26. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2008
    ..abstract_text> ..
  27. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2000
    ....
  28. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2002
    ....
  29. Towards a Novel Strategy Against HBV Infection
    John Taylor; Fiscal Year: 2007
    ..Then, in collaboration with Stressgen Biotechnologies, the developed assays will be used to screen multiple compounds to increase efficacy, and ultimately move to clinical studies. ..
  30. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2005
    ..abstract_text> ..
  31. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 2003
    ....
  32. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 1990
    ..The sequences will also be tested for relationship to those of the retrovirus-like particles, reportedly released from embryonic quail tissues, in the studies of Hofschneider and coworkers...
  33. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 1999
    ....
  34. Structure and Function of Antiparallel Coiled Coils
    MARTHA OAKLEY; Fiscal Year: 2005
    ..We propose a combination of biophysical and functional studies that explore the importance of coiled-coil length and sequence for function of bacterial SMC proteins in vivo. ..
  35. HCV NS4B: Translating molecular virology into novel antiviral therapies
    Jeffrey S Glenn; Fiscal Year: 2010
    ....
  36. EXPLOITING DNA BINDING TO STUDY COILED/COIL INTERACTIONS
    MARTHA OAKLEY; Fiscal Year: 1999
    ..In addition, these studies will also be crucial for translating the primary sequence of putative coiled-coil proteins into structural and functional information. ..
  37. EXPLOITING DNA BINDING TO STUDY COILED/COIL INTERACTIONS
    MARTHA OAKLEY; Fiscal Year: 2000
    ..In addition, these studies will also be crucial for translating the primary sequence of putative coiled-coil proteins into structural and functional information. ..
  38. EXPLOITING DNA BINDING TO STUDY COILED/COIL INTERACTIONS
    MARTHA OAKLEY; Fiscal Year: 2001
    ..In addition, these studies will also be crucial for translating the primary sequence of putative coiled-coil proteins into structural and functional information. ..
  39. EXPLOITING DNA BINDING TO STUDY COILED/COIL INTERACTIONS
    MARTHA OAKLEY; Fiscal Year: 2002
    ..In addition, these studies will also be crucial for translating the primary sequence of putative coiled-coil proteins into structural and functional information. ..
  40. Structure and Function of Antiparallel Coiled Coils
    MARTHA OAKLEY; Fiscal Year: 2003
    ..We propose a combination of biophysical and functional studies that explore the importance of coiled-coil length and sequence for function of bacterial SMC proteins in vivo. ..
  41. Structure and Function of Antiparallel Coiled Coils
    MARTHA OAKLEY; Fiscal Year: 2006
    ..We propose a combination of biophysical and functional studies that explore the importance of coiled-coil length and sequence for function of bacterial SMC proteins in vivo. ..
  42. Structure and Function of Antiparallel Coiled Coils
    MARTHA OAKLEY; Fiscal Year: 2004
    ..We propose a combination of biophysical and functional studies that explore the importance of coiled-coil length and sequence for function of bacterial SMC proteins in vivo. ..
  43. HCV NS5A: Molecular Virology and Antiviral Target
    Jeffrey S Glenn; Fiscal Year: 2010
    ..We will use phage display to identify high affinity random peptide ligands of the AH. Finally, we will explore how our results can be translated into novel anti-HCV strategies. ..