neural cell adhesion molecule l1

Summary

Summary: A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.

Top Publications

  1. ncbi Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons
    Eduardo Gascon
    Department of Neuroscience, University of Geneva Medical School, 1, rue Michel Servet, CH 1211, Geneva, Switzerland
    Brain Res Rev 56:101-18. 2007
  2. ncbi Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells
    Michael Shtutman
    Cancer Center, Ordway Research Institute, Albany, New York 12208, USA
    Cancer Res 66:11370-80. 2006
  3. pmc A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44
    Alexander Stoeck
    Tumor Immunology Programme, D010, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochem J 393:609-18. 2006
  4. pmc L1CAM: a major driver for tumor cell invasion and motility
    Helena Kiefel
    Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Cell Adh Migr 6:374-84. 2012
  5. pmc Cryo-electron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1
    Yongning He
    Division of Biology 114 96, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Structure 17:460-71. 2009
  6. doi L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma
    Jeong Ki Min
    Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungnam National University School of Medicine, Daejon, Korea
    Clin Cancer Res 16:3571-80. 2010
  7. pmc Pathogenic human L1-CAM mutations reduce the adhesion-dependent activation of EGFR
    Kakanahalli Nagaraj
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, 48109 2200, USA
    Hum Mol Genet 18:3822-31. 2009
  8. pmc L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions
    Marco Pfeifer
    German Cancer Research Center, Department of Translational Immunology, Heidelberg, Germany
    BMC Mol Biol 11:64. 2010
  9. doi Targeting l1 cell adhesion molecule using lentivirus-mediated short hairpin RNA interference reverses aggressiveness of oral squamous cell carcinoma
    Shiao Chen Hung
    Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University and Hospital, Taichung, Taiwan
    Mol Pharm 7:2312-23. 2010
  10. ncbi Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death
    Martin S L Hammond
    Zentrum für Molekulare Neurobiologie Hamburg and Institut für Neurophysiologie und Pathophysiologie, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 281:34859-69. 2006

Research Grants

  1. L1 SIGNALING IN X-LINKED MENTAL RETARDATION
    Patricia Maness; Fiscal Year: 2000
  2. L1 SIGNALING IN X-LINKED MENTAL RETARDATION
    Patricia Maness; Fiscal Year: 1999
  3. ALCOHOL INTERACTION WITH L1 CELL ADHESION MOLECULE
    MICHAEL CHARNESS; Fiscal Year: 1999
  4. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2009
  5. ALCOHOL AND CELL ADHESION
    MICHAEL EDWARD CHARNESS; Fiscal Year: 2010
  6. Targeting Pathways of Axonal Cell Adhesion Molecules
    BETTINA R WINCKLER; Fiscal Year: 2010
  7. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2009
  8. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    Tanja Godenschwege; Fiscal Year: 2009
  9. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    Tanja Godenschwege; Fiscal Year: 2009
  10. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    TANJA ANGELA GODENSCHWEGE; Fiscal Year: 2010

Detail Information

Publications261 found, 100 shown here

  1. ncbi Polysialic acid-neural cell adhesion molecule in brain plasticity: from synapses to integration of new neurons
    Eduardo Gascon
    Department of Neuroscience, University of Geneva Medical School, 1, rue Michel Servet, CH 1211, Geneva, Switzerland
    Brain Res Rev 56:101-18. 2007
    ..In this review, we discuss the role and mode of actions of PSA-NCAM in structural plasticity as well as its potential link to cognitive processes...
  2. ncbi Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells
    Michael Shtutman
    Cancer Center, Ordway Research Institute, Albany, New York 12208, USA
    Cancer Res 66:11370-80. 2006
    ..Based on these results, we propose a model for the role of L1 as a trigger of EMT-like events in transformed epithelial cells...
  3. pmc A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44
    Alexander Stoeck
    Tumor Immunology Programme, D010, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochem J 393:609-18. 2006
    ..Our findings open up the possibility that exosomes serve as a platform for ectodomain shedding and as a vehicle for the cellular export of soluble molecules...
  4. pmc L1CAM: a major driver for tumor cell invasion and motility
    Helena Kiefel
    Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Cell Adh Migr 6:374-84. 2012
    ....
  5. pmc Cryo-electron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1
    Yongning He
    Division of Biology 114 96, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Structure 17:460-71. 2009
    The neural cell adhesion molecule L1 participates in homophilic interactions important for axon guidance and neuronal development...
  6. doi L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma
    Jeong Ki Min
    Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungnam National University School of Medicine, Daejon, Korea
    Clin Cancer Res 16:3571-80. 2010
    ..Intrahepatic cholangiocarcinoma (ICC), a highly malignant hepatobiliary cancer, has a poor prognosis and is refractory to conventional therapies. The aim of this study is to discover a novel molecular target for the treatment of ICC...
  7. pmc Pathogenic human L1-CAM mutations reduce the adhesion-dependent activation of EGFR
    Kakanahalli Nagaraj
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, 48109 2200, USA
    Hum Mol Genet 18:3822-31. 2009
    ..Either by reducing or abolishing L1-CAM protein expression, by interfering with L1-CAM's cell surface expression, by reducing L1-CAM's adhesive ability or by impeding further downstream adhesion-dependent signaling processes...
  8. pmc L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions
    Marco Pfeifer
    German Cancer Research Center, Department of Translational Immunology, Heidelberg, Germany
    BMC Mol Biol 11:64. 2010
    ..Previous studies have implied the transcription factors Slug and/or β-catenin in L1CAM transcriptional regulation. However, the regulation of human L1CAM expression at the transcriptional level is not well understood...
  9. doi Targeting l1 cell adhesion molecule using lentivirus-mediated short hairpin RNA interference reverses aggressiveness of oral squamous cell carcinoma
    Shiao Chen Hung
    Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University and Hospital, Taichung, Taiwan
    Mol Pharm 7:2312-23. 2010
    ..Our findings suggested that L1CAM is a critical mediator of tumor progression in OSCC, and targeting L1CAM using lentivirus-mediated shRNA may be a useful molecular pharmaceutical approach for the treatment of advanced OSCC...
  10. ncbi Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death
    Martin S L Hammond
    Zentrum für Molekulare Neurobiologie Hamburg and Institut für Neurophysiologie und Pathophysiologie, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 281:34859-69. 2006
    ..These observations indicate that the cell adhesion molecule-associated glycan polysialic acid is able to prevent excitotoxicity via inhibition of NR2B subunit-containing NMDA receptors...
  11. pmc Ectopic expression of polysialylated neural cell adhesion molecule in adult macaque Schwann cells promotes their migration and remyelination potential in the central nervous system
    C Bachelin
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Universite Pierre et Marie Curie Paris 6, UMR S975, Paris, France
    Brain 133:406-20. 2010
    ..These results underline the potential therapeutic benefit to genetically modify Schwann cells to overcome their poor migration capacity and promote their repair potential in demyelinating disorders of the central nervous system...
  12. doi Structural mechanism of the antigen recognition by the L1 cell adhesion molecule antibody A10-A3
    Chun Hua Wei
    Department of Bio Engineering, Hanyang University, Seoul, Republic of Korea
    FEBS Lett 585:153-8. 2011
    ..The data presented here should contribute to the design of high-affinity antibody for therapeutic purposes as well as to the understanding of neural cell remodeling and cancer progression mechanism mediated by L1CAM...
  13. doi The interaction between cell adhesion molecule L1, matrix metalloproteinase 14, and adenine nucleotide translocator at the plasma membrane regulates L1-mediated neurite outgrowth of murine cerebellar neurons
    Gabriele Loers
    Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    J Neurosci 32:3917-30. 2012
    ..Thus, our results indicate that plasma membrane-localized ANT1 and ANT2 regulate L1-mediated neurite outgrowth in conjunction with MMP14...
  14. ncbi Non-granule PSA-NCAM immunoreactive neurons in the rat hippocampus
    Juan Nacher
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, York Avenue 1230, New York, NY 10021, USA
    Brain Res 930:1-11. 2002
    ..The presence of the polysialylated form of NCAM in these neurons could indicate that they are undergoing continuous remodeling during adulthood and may have an important role in hippocampal structural plasticity...
  15. pmc Growth-associated protein GAP-43 and L1 act synergistically to promote regenerative growth of Purkinje cell axons in vivo
    Yi Zhang
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:14883-8. 2005
    ....
  16. ncbi Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment
    Matthias J E Arlt
    Klinikum rechts der Isar der Technischen Universitat Munchen, Institut für Experimentelle Onkologie und Therapieforschung, Ismaninger Strasse 22, D 81675 Munich, Germany
    Cancer Res 66:936-43. 2006
    ....
  17. doi The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed in a subpopulation of mature cortical interneurons characterized by reduced structural features and connectivity
    Maria Angeles Gomez-Climent
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Department of Cell Biology, Universitat de Valencia, 46100 Burjassot, Spain
    Cereb Cortex 21:1028-41. 2011
    ..These data indicate that PSA-NCAM expression is important for the connectivity of interneurons in the adult cerebral cortex and that its regulation may play an important role in the structural plasticity of inhibitory networks...
  18. ncbi Peptide-mediated protection from ethanol-induced neural tube defects
    Shao Yu Chen
    Bowles Center for Alcohol Studies and Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Dev Neurosci 27:13-9. 2005
    ..These findings demonstrate the ability of NAP and SAL to prevent ethanol-induced NTDs and support the hypothesis that ethanol teratogenesis is caused in part by ethanol inhibition of L1-mediated cell adhesion...
  19. doi L1CAM malfunction in the nervous system and human carcinomas
    Michael K E Schäfer
    Center for Neurosciences, Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany
    Cell Mol Life Sci 67:2425-37. 2010
    ..We further discuss how the available data on gene regulation, molecular interactions and posttranslational processing of L1 may contribute to a better understanding of associated neurological and cancerous diseases...
  20. pmc L1 cell adhesion molecules as regulators of tumor cell invasiveness
    Priscila F Siesser
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 7260, USA
    Cell Adh Migr 3:275-7. 2009
    ..Despite the promising advances in cancer basic research, a better understanding of the molecular mechanisms dictating L1-mediated signaling is needed for the development of effective therapeutic treatment for cancer patients...
  21. ncbi Copper-67 radioimmunotherapy and growth inhibition by anti-L1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis
    Karin Knogler
    Center for Radiopharmaceutical Science, ETH PSI USZ, Paul Scherrer Institute, CH 5232 Villigen, Switzerland
    Clin Cancer Res 13:603-11. 2007
    ..We examined the tumor-targeting and therapeutic effects of (67)Cu-labeled single amino acid mutant forms of anti-L1 monoclonal antibody chCE7 in nude mice with orthotopically implanted SKOV3ip human ovarian carcinoma cells...
  22. pmc Kinetic analysis of L1 homophilic interaction: role of the first four immunoglobulin domains and implications on binding mechanism
    Ricardo M Gouveia
    Instituto de Tecnologia Quimica e Biologica, Avenida da República, Apartado 127, 2780 157 Oeiras, Portugal
    J Biol Chem 283:28038-47. 2008
    ..Furthermore, they are compatible with a cooperative interaction between modules Ig1-Ig4 in a horseshoe conformation...
  23. ncbi Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion
    Steve Silletti
    Department of Pediatrics, The Whittier Institute, and Moores Comprehensive Cancer Center, University of California at San Diego, La Jolla, California 92037, USA
    J Biol Chem 279:28880-8. 2004
    ..This study provides a novel translational mechanism to account for the association between L1 expression and motile processes involved in metastasis and development...
  24. ncbi Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma
    Anka Thies
    Institut fur Anatomie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Eur J Cancer 38:1708-16. 2002
    ..The functional role of L1 was further stressed by the fact that its expression was preserved in metastatic lesions...
  25. doi Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer
    Claudia Geismann
    Clinic of Internal Medicine, Laboratory of Molecular Gastroenterology and Hepatology, UKSH Campus Kiel, Kiel, Germany
    Cancer Res 69:4517-26. 2009
    ..Our data provide new insights into the mechanisms of tumoral L1CAM induction and how PMFs contribute to malignant transformation of pancreatic duct cells early in PDAC tumorigenesis...
  26. ncbi Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity
    J Z Kiss
    Department of Morphology, , Geneva, Switzerland
    Rev Neurosci 12:297-310. 2001
    ..Some of these mechanisms are discussed and a hypothesis is proposed based on the existence of cross-talk between these molecules and signalling pathways mediated by growth factors...
  27. ncbi PSA-NCAM in mammalian structural plasticity and neurogenesis
    Luca Bonfanti
    Department of Veterinary Morphophysiology, University of Turin, Via Leonardo da Vinci 44, 10095 Grugliasco, Italy
    Prog Neurobiol 80:129-64. 2006
    ..The use of PSA-NCAM as a marker for exploring differences in structural plasticity and neurogenesis among mammalian species is also discussed...
  28. ncbi PSA-NCAM expression in the human prefrontal cortex
    Emilio Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Dr Moliner 50, Burjassot 46100, Spain
    J Chem Neuroanat 33:202-9. 2007
    ..Since this molecule has been linked to the neuronal remodeling found in experimental models of depression, it may also participate in the structural plasticity described in the PFC of depressed patients...
  29. ncbi Distribution of PSA-NCAM expression in the amygdala of the adult rat
    J Nacher
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroscience 113:479-84. 2002
    ..PSA-NCAM expression in the lateral amygdala could indicate its participation in the plastic events that lead to the generation of emotional memories such as those related to fear conditioning...
  30. ncbi Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat
    M Sairanen
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, P O Box 56, 00014 University of Helsinki, Helsinki, Finland
    Neuroscience 144:368-74. 2007
    ..Taken together, the results of the present study suggest that antidepressant treatment increases synaptic plasticity and connectivity in brain regions associated with mood disorders...
  31. doi Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation
    S Bondong
    Department of Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Ann Oncol 23:1795-802. 2012
    ..We tested L1CAM and interleukin-1 beta (IL-1β) expression in tumor samples and ascitic fluid from ovarian carcinoma patients to examine its role as a prognostic marker...
  32. ncbi Polysialylation of NCAM is upregulated by hyperthermia and participates in heat shock preconditioning-induced neuroprotection
    V Duveau
    Universite Bordeaux 2, CNRS UMR 5227 Mouvement, Adaptation, Cognition, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Neurobiol Dis 26:385-95. 2007
    ..The upregulation of PSA-NCAM by hyperthermia may have a significant impact on hippocampal plasticity, permitting induction of the complex molecular cascade responsible for neuroprotection...
  33. pmc A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice
    Alexis Tapanes-Castillo
    The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Lois Pope LIFE Center, Room 4 16, 1095 NW 14th Terrace, Miami, FL 33136, USA
    Neurogenetics 11:53-71. 2010
    ..Candidate modifier loci were further investigated in an extension study. Linkage was confirmed for a locus on chromosome 5, which we named L1cam hydrocephalus modifier 1 (L1hydro1), p = 4.04 X 10(-11)...
  34. ncbi Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury
    Daria Guseva
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Hamburg, Germany
    Brain 132:2180-95. 2009
    ..We propose that L1 negatively regulates Schwann cell proliferation after nerve damage, which in turn restricts functional recovery by limiting the trophic support for regenerating motoneurons...
  35. ncbi The role of cytoplasmic serine residues of the cell adhesion molecule L1 in neurite outgrowth, endocytosis, and cell migration
    M Schultheis
    Department of Biochemistry, Institute of Animal Sciences, University of Bonn, Katzenburgweg 9a, 53115, Bonn, Germany
    Cell Mol Neurobiol 27:11-31. 2007
    ..Furthermore, mutation of ser-1181 to leucine results in strongly enhanced antibody-induced endocytosis of L1 and also in enhanced cell migration...
  36. ncbi Pathological missense mutations of neural cell adhesion molecule L1 affect neurite outgrowth and branching on an L1 substrate
    Ling Cheng
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA
    Mol Cell Neurosci 27:522-30. 2004
    ..Some pathological mutations have little effect on L1 mediated neurite growth, so it is unlikely that a failure of L1-mediated neurite outgrowth is the principle cause of brain defects in patients with L1 mutations...
  37. pmc Developmental regulation of neural cell adhesion molecule in human prefrontal cortex
    E T Cox
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuroscience 162:96-105. 2009
    ....
  38. pmc L1 stimulation of human glioma cell motility correlates with FAK activation
    Muhua Yang
    Department of Biological Sciences, University of Delaware, Wolf Hall, Newark, DE 19716, USA
    J Neurooncol 105:27-44. 2011
    ....
  39. pmc Activation of EGF receptor kinase by L1-mediated homophilic cell interactions
    Rafique Islam
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Biol Cell 15:2003-12. 2004
    ..Thus L1-type CAMs are able to promote the adhesion-dependent activation of EGF receptor signaling in vitro and in vivo...
  40. doi Expression of l1 cell adhesion molecule and morphologic features at the invasive front of colorectal cancer
    Yoshiki Kajiwara
    Department of Surgery, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    Am J Clin Pathol 136:138-44. 2011
    ..0004). L1CAM expression was correlated with nodal involvement in protein and mRNA levels (P = .0007 and P = .036, respectively). Tumor regulation of L1CAM expression is associated with morphologic features at the invasive front in CRC...
  41. doi Pathomechanistic characterization of two exonic L1CAM variants located in trans in an obligate carrier of X-linked hydrocephalus
    Mariola Marx
    Institute of Anatomy and Cell Biology, Center for Neurosciences, University of Freiburg, Freiburg, Germany
    Neurogenetics 13:49-59. 2012
    ..The poly-ubiquitination of L1-W635C and its association with the ER chaperone calnexin provide further insights into the molecular mechanisms underlying defective cell surface trafficking of L1CAM in L1 syndrome...
  42. doi Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma
    Silke Wolterink
    Tumor Immunology Program, Translational Immunology Unit D015, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 70:2504-15. 2010
    ..Our results establish that anti-L1 mAb therapy acts via immunologic and nonimmunologic effector mechanism to block tumor growth. The novel antibodies to L1CAM could become helpful tools for the therapy of L1-positive human carcinomas...
  43. doi L1 cell adhesion molecule as a novel independent poor prognostic factor in gallbladder carcinoma
    Song Yi Choi
    Department of Pathology, Chungnam National University School of Medicine, Daejeon, South Korea
    Hum Pathol 42:1476-83. 2011
    ..Taken together, our findings suggest that L1 cell adhesion molecule expression could be used as a novel prognostic factor for patient survival and might be a potential therapeutic target in gallbladder carcinomas...
  44. pmc Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development
    Yukiko Nakamura
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Comp Neurol 518:1113-32. 2010
    ..Therefore, the L1CD is not responsible for the major defects observed in L1(KO) mice, yet it is required for continued L1 protein expression and motor function in the adult...
  45. pmc Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions
    Kyoko Itoh
    Neurosciences, Case Western Reserve University, Cleveland, OH, USA
    Mol Cell Neurosci 30:624-9. 2005
    ..Taken together, it is likely that L1 on axons binds integrins on Schwann cells, resulting in interactions between axons and Schwann cells that are essential for ensheathment and myelination...
  46. doi L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells
    Hyunho Yoon
    Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
    Cancer Lett 316:70-6. 2012
    ..Inhibition of EGFR activation or L1ACM greatly sensitized the cells to cisplatin. EGFR and L1CAM may be important targets for ICC therapy...
  47. doi Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice
    Javier Gilabert-Juan
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt, Universitat de Valencia, Spain
    Exp Neurol 232:33-40. 2011
    ..The addition of PSA to NCAM by St8SiaII may be involved in these changes...
  48. doi The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo
    Juyeon Jung
    Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun dong, Yuseong Gu, Daejeon 305 333, Republic of Korea
    Oncol Rep 25:945-52. 2011
    ..Taken together, these results suggest that L1 plays a crucial role in GBC progression and may be a novel therapeutic target in GBC treatment...
  49. ncbi Axonal regeneration from CNS neurons in the cerebellum and brainstem of adult rats: correlation with the patterns of expression and distribution of messenger RNAs for L1, CHL1, c-jun and growth-associated protein-43
    V Chaisuksunt
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroscience 100:87-108. 2000
    ....
  50. doi Linking L1CAM-mediated signaling to NF-κB activation
    Helena Kiefel
    Translational Immunology, D015, German Cancer Research Center, 69120 Heidelberg, Germany
    Trends Mol Med 17:178-87. 2011
    ..Taken together, these findings lead to a new understanding of L1CAM downstream signaling that is fundamental for the development of anti-L1CAM antibody-mediated therapeutics in human tumor cells...
  51. ncbi L1 cell adhesion molecule as a predictor for recurrence in pulmonary carcinoids and large-cell neuroendocrine tumors
    Hyo Song Kim
    Samsung Medical Center, Division of Hematology Oncology, Sungkyunkwan University School of Medicine, 50 Ilwon dong Kangnam gu, Seoul, Korea
    APMIS 117:140-6. 2009
    ..0; 95% confidence interval, 1.2-8.3; p=0.034). L1 expression is significantly associated with aggressiveness and further studies with larger samples are needed to validate potential prognostic value for pulmonary neuroendocrine tumors...
  52. doi L1 cell adhesion molecule (L1CAM) in invasive tumors
    Shani Raveh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Cancer Lett 282:137-45. 2009
    ..We review the role of L1CAM in cancer progression with particular emphasis on colon cancer, and the potential of anti-L1CAM antibodies as a therapeutic tool for cancer...
  53. pmc Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity
    Michael F Wilkemeyer
    Neurology Service, Veterans Affairs Boston Healthcare System, West Roxbury and Department of Neurology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Proc Natl Acad Sci U S A 100:8543-8. 2003
    ....
  54. doi L1 syndrome mutations impair neuronal L1 function at different levels by divergent mechanisms
    Michael K E Schäfer
    Institut fur Anatomie und Zellbiologie, Universitat Freiburg, 79104 Freiburg, Germany
    Neurobiol Dis 40:222-37. 2010
    ..Our results indicate that L1 syndrome mutations impair neuronal L1 function at different levels, firstly by attenuating ER export and secondly by interfering with polarized neuronal trafficking...
  55. ncbi L1 adhesion molecule (CD 171) in development and progression of human malignant melanoma
    Mina Fogel
    Department of Pathology, Kaplan Hospital, Rehovot, Israel
    Cancer Lett 189:237-47. 2003
    ..Our findings suggest that the presence of L1 might contribute to tumor progression by promoting cell adhesion and migration...
  56. ncbi Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens
    Nicole I Euer
    Roche Diagnostics GmbH, Pharma Research, Im Nonnenwald 2, D 82372 Penzberg, Germany
    Oncol Rep 13:375-87. 2005
    ..Functional investigation of stable Delta(2,27)L1CAM transfectants of the ovarian tumor cell line OV-MZ-2 revealed significantly stronger adhesion to laminin in comparison to mock transfectants...
  57. doi Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration
    Yasmin Issa
    Tumor Immunology Programme, D015, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:99-112. 2009
    ..Our data demonstrate a functional role of L1CAM expression on tumor endothelium that could favor metastasis and angiogenesis during tumor progression...
  58. pmc Targeting cancer stem cells through L1CAM suppresses glioma growth
    Shideng Bao
    Department of Surgery, Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 68:6043-8. 2008
    ....
  59. pmc An alcohol binding site on the neural cell adhesion molecule L1
    Enrique Arevalo
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:371-5. 2008
    Prenatal ethanol exposure causes fetal alcohol spectrum disorders (FASD) in part by disrupting the neural cell adhesion molecule L1. L1 gene mutations cause neuropathological abnormalities similar to those of FASD...
  60. pmc L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth
    Ralf S Schmid
    Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, NC 27704, USA
    Curr Opin Neurobiol 18:245-50. 2008
    ..We will also discuss how dysregulation of CAMs may also bear on neuropsychiatric disease and cancer...
  61. pmc L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
    J Cell Biol 168:633-42. 2005
    ..The transmembrane localization and shedding of L1 by metalloproteases could be useful for detection and as target for colon cancer therapy...
  62. ncbi An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia
    K Sakurai
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305 8575, Ibaraki, Japan
    Mol Psychiatry 7:412-5. 2002
    ..28-2.26) for the Leu/Leu genotype compared with the other genotypes. An association between this CHL1 gene polymorphism and schizophrenia supports the notion that cell adhesion molecules are involved in the etiology of schizophrenia...
  63. ncbi L1-CAM in cancerous tissues
    Nancy Gavert
    Weizmann Institute of Science, Department of Molecular Cell Biology, Rehovot, Israel
    Expert Opin Biol Ther 8:1749-57. 2008
    ..While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer...
  64. ncbi Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon
    E Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Spain
    Eur Neuropsychopharmacol 17:546-57. 2007
    ..The expression of these molecules is also affected in the entorhinal, the visual and the somatosensory cortices...
  65. ncbi Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm
    Oleg Senkov
    Center for Molecular Neurobiology, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    J Neurosci 26:10888-109898. 2006
    ..In conclusion, our data support the view that polysialylated NCAM is involved in both formation and late consolidation of contextual memory...
  66. doi Up-regulation of L1CAM is linked to loss of hormone receptors and E-cadherin in aggressive subtypes of endometrial carcinomas
    Monica Huszar
    Department of Pathology, Kaplan Medical Centre, Rehovot, Israel
    J Pathol 220:551-61. 2010
    ..According to our analysis, we suggest that L1CAM is a novel marker for EMT in ECs and that L1CAM-typing could identify endometrioid ECs that have type 2-like features and are at high risk for recurrence...
  67. ncbi PSA-NCAM expression in the rat medial prefrontal cortex
    E Varea
    Neurobiology, Cell Biology Department, Universitat de Valencia, Dr Moliner, 50, 46100 Burjassot, Valencia, Spain
    Neuroscience 136:435-43. 2005
    ....
  68. ncbi PSA-NCAM expression in the piriform cortex of the adult rat. Modulation by NMDA receptor antagonist administration
    Juan Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 927:111-21. 2002
    ..Similar to the hippocampus, NMDA receptors appear to play a critical role in these processes in the adult piriform cortex...
  69. ncbi Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex
    Emilio Varea
    Cell Biology Department, Neurobiology Unit, Program in Basic and Applied Neurosciences, Universitat de Valencia, Burjassot, Spain
    Neuropsychopharmacology 32:803-12. 2007
    ..This modulation may mediate the structural plasticity of this cortical region and opens new perspectives on the study of the molecular bases of depression...
  70. ncbi L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer
    Yoon Jung Boo
    Department of Surgery, Korea University College of Medicine, Seoul, Korea
    Ann Surg Oncol 14:1703-11. 2007
    ....
  71. ncbi The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies
    D Gast
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Oncogene 27:1281-9. 2008
    ..These findings provide a rationale for the mode of action of L1 antibodies and suggest that interference with L1 function could become a valuable target for therapy...
  72. ncbi Schwann cells genetically engineered to express PSA show enhanced migratory potential without impairment of their myelinating ability in vitro
    Alexandros A Lavdas
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vas Sofias, 11521 Athens, Greece
    Glia 53:868-78. 2006
    ..Thus, migratory properties of PNS myelin-forming cells within the CNS can be enhanced without altering their differentiation program. This finding may be beneficial for the development of remyelination therapies...
  73. ncbi Differential evolution of PSA-NCAM expression during aging of the rat telencephalon
    Emilio Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt, Universitat de Valencia, Dr Moliner 50, Burjassot 46100, Spain
    Neurobiol Aging 30:808-18. 2009
    ..Given the role of PSA-NCAM in neuronal plasticity, the present results indicate that, even during aging, many regions of the CNS may display neurite, spine or synaptic remodeling...
  74. ncbi Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus
    Kara Pham
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 17:879-86. 2003
    ..These studies may help us understand the basis for hippocampal shrinkage and raise questions about the ultimate reversibility of the effects of chronic stress...
  75. ncbi Cell adhesion molecules of the immunoglobulin superfamily in axonal regeneration and neural repair
    Yi Zhang
    Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK
    Restor Neurol Neurosci 26:81-96. 2008
    ..This review will be focussed on the involvement of L1, NCAM, and polysialylated NCAM in neural repair and axon regeneration after nerve injury and their potential applications in the treatment of CNS injury...
  76. ncbi Soluble cell adhesion molecule L1-Fc promotes locomotor recovery in rats after spinal cord injury
    Chanland Roonprapunt
    Department of Neurosurgery, Albert Einstein School of Medicine, New York, NY, USA
    J Neurotrauma 20:871-82. 2003
    ..Thus, L1 may be stimulating growth of other motor tracts or protecting axons and neurons. More studies are required to elucidate the mechanisms of L1-Fc-induced locomotor recovery...
  77. doi Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma
    Qi Wen Ben
    Department of Gastroenterology, School of Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, People s Republic of China
    Ann Surg Oncol 17:2213-21. 2010
    ..We evaluated whether L1 cell adhesion molecule (L1-CAM) and glial cell line-derived neurotrophic factor (GDNF) expression in PDAC correlated with neural invasion and overall survival on a large cohort of previously untreated patients...
  78. doi Dopamine acting through D2 receptors modulates the expression of PSA-NCAM, a molecule related to neuronal structural plasticity, in the medial prefrontal cortex of adult rats
    Esther Castillo-Gomez
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Spain
    Exp Neurol 214:97-111. 2008
    ..Our results give support to the "neuroplastic" hypothesis of depression, suggesting that dopamine acting on D2 receptors may modulate neuronal structural plasticity and inhibitory neurotransmission through changes in PSA-NCAM expression...
  79. ncbi Engineered expression of polysialic acid enhances Purkinje cell axonal regeneration in L1/GAP-43 double transgenic mice
    Yi Zhang
    Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Road, Whitechapel, London E1 2AT, UK
    Eur J Neurosci 25:351-61. 2007
    ..Our result suggests that transplanted Schwann cells engineered to express PSA support axonal regeneration better than naïve Schwann cells...
  80. doi L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression
    H Kiefel
    Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Oncogene 29:4766-78. 2010
    ..The unravelling of this novel mechanism sheds new light on the important role of L1CAM expression in PDAC cells...
  81. ncbi L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas
    Daniela Gast
    Tumor Immunology Programme, D010, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 115:658-65. 2005
    ..Our results suggest that L1 could drive progression by enhancing cell migration and tumor growth but that L1 dependent and erk-regulated gene expression requires cell-type specific elements...
  82. ncbi State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders
    Yusuke Wakabayashi
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1199-205. 2008
    ..Our results suggest that the reciprocal alteration in the expression of NCAM-140 and L1 mRNAs could be state-dependent and associated with the pathophysiology of bipolar disorder...
  83. ncbi Transforming growth factor beta1 and ethanol affect transcription and translation of genes and proteins for cell adhesion molecules in B104 neuroblastoma cells
    Michael W Miller
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Neurochem 97:1182-90. 2006
    ..Thus, the effects of TGFbeta1 and ethanol on CAPs parallel changes described in vivo and likely underlie changes associated with ethanol-induced alterations in neuronal migration...
  84. ncbi The L1 cell adhesion molecule is induced in renal cancer cells and correlates with metastasis in clear cell carcinomas
    Yves Allory
    INSERM U489, Tenon Hospital Assistance Publique Hôpitaux de Paris and Paris 6 University, 4 rue de la Chine, Paris 70520, France
    Clin Cancer Res 11:1190-7. 2005
    ..The objectives of the study were to provide a comprehensive description of L1 distribution in human kidney and to establish the prognostic relevance of L1 expression in renal cell carcinomas (RCC)...
  85. doi The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor
    Alexandra Friedli
    Center for Radiopharmaceutical Science ETH PSI USZ, Paul Scherrer Institute, Villigen, Switzerland
    Int J Biochem Cell Biol 41:1572-80. 2009
    ..These results indicate an important role of released L1 in tumor angiogenesis and represent a novel function of antibody chCE7 in tumor therapy...
  86. ncbi DNA hypomethylation at the CpG island is involved in aberrant expression of the L1 cell adhesion molecule gene in colorectal cancer
    Kuniyuki Kato
    Department of Pathology, Iwate Medical University School of Medicine, 18 1 Uchimaru, Morioka, Japan
    Int J Oncol 35:467-76. 2009
    ..These results suggest that DNA hypomethylation at the L1CAM CpG islands might induce L1CAM aberrant expression and contribute to the acquisition of aggressive tumor behavior in CRC...
  87. ncbi Expression and prognostic value of L1-CAM in breast cancer
    Christine Schröder
    Department of Gynecology, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Oncol Rep 22:1109-17. 2009
    ..Given the emerging functional role of L1 in promoting tumor cell migration, invasion, tumor growth and metastasis, our results suggest that L1 may have this function in breast cancer as well...
  88. ncbi Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming growth factor-β1 (TGF-β)-induced L1CAM expression in human pancreatic ductal adenocarcinoma cells
    Claudia Geismann
    Department of Internal Medicine 1, Laboratory of Molecular Gastroenterology and Hepatology, UKSH Campus Kiel, Arnold Heller Strasse 3, Bldg 6, 24105 Kiel, Germany
    Int J Oncol 38:257-66. 2011
    ..Moreover, our study is the first one describing the control of the human L1CAM promoter in tumor cells...
  89. pmc Ethanol causes the redistribution of L1 cell adhesion molecule in lipid rafts
    Ningfeng Tang
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21209, USA
    J Neurochem 119:859-67. 2011
    ..These data indicate that ethanol may inhibit L1-mediated neurite outgrowth by retarding L1 trafficking through a lipid raft compartment...
  90. ncbi L1 cell adhesion molecule is a novel independent poor prognostic factor of extrahepatic cholangiocarcinoma
    Shengjin Li
    Department of Pathology and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Korea
    Clin Cancer Res 15:7345-51. 2009
    ..Here, we analyzed L1 expression in extrahepatic CC (ECC) and evaluated its prognostic significance...
  91. ncbi Removal of PSA from NCAM affects the survival of magnocellular vasopressin- and oxytocin-producing neurons in organotypic cultures of the paraventricular nucleus
    L Vutskits
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, Geneva, Switzerland
    Eur J Neurosci 17:2119-26. 2003
    ..These results suggest that, in addition to its role in neuro-glial plasticity, PSA-NCAM might also influence the trophic factor responsiveness of hypothalamic VP and OT neurosecretory cells...
  92. ncbi Expression of L1 cell adhesion molecule is a significant prognostic factor in pT3-stage gastric cancer
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Anticancer Res 29:4033-9. 2009
    ..L1, a 200-220 kDa transmembrane glycoprotein of the immunoglobulin superfamily, has been shown to affect prognosis of various types of cancer and was shown to enhance peritoneal metastasis in ovarian cancer in vivo...
  93. ncbi Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells
    Nancy Gavert
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    J Cell Sci 123:2135-43. 2010
    ..Furthermore, we found that L1, ezrin and phosphorylated p65 are co-expressed at the invasive front in human CRC tissue, indicating that L1-mediated activation of NF-kappaB signaling involving ezrin is a major route of CRC progression...
  94. doi An updated and upgraded L1CAM mutation database
    Yvonne J Vos
    Department of Genetics, University Medical Centre Groningen, University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Hum Mutat 31:E1102-9. 2010
    ..The L1CAM Mutation Database is at: www.l1cammutationdatabase.info...
  95. pmc A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma model
    Eung Suk Lee
    Department of Systems Immunology and Institute of Antibody Research, College of Biomedical Science, Kangwon National University, Chuncheon 200 701, Korea
    Exp Mol Med 44:293-302. 2012
    ..These results suggest that the humanized A10-A3 antibody may have potential as an anticancer agent for the treatment of ICC...
  96. pmc Morphometrical study of polysialylated neural cell adhesion molecule positive cells in rat pups hippocampus following induction of seizure during pregnancy
    Ali Akbar Rajabzadeh
    Dept of Anatomy and and Cellular Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran Biomed J 15:157-63. 2011
    ..Fetal brain damage is caused by different conditions such as seizure and hypoxia. The present study was designed to investigate the effect of maternal seizures on the number of PSA-NCAM positive cells in pup's hippocampus...
  97. ncbi L1 is associated with favorable outcome in neuroblastomas in contrast to adult tumors
    Robin Wachowiak
    Department of Pediatric Surgery, University Medical Center, 04103, Leipzig, Germany
    Ann Surg Oncol 14:3575-80. 2007
    ..L1, a neuronal cell adhesion molecule, is associated with poor survival in malignant adult tumors. The aim of the current study was to determine expression of L1 in pediatric neuroblastoma...
  98. ncbi Involvement of highly polysialylated neural cell adhesion molecule (PSA-NCAM)-positive granule cells in the amygdaloid-kindling-induced sprouting of a hippocampal mossy fiber trajectory
    Takashi Saegusa
    Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Neurosci Res 48:185-94. 2004
    ....
  99. pmc Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion
    T Suzuki
    Department of Neurosurgery, Osaka University Medical School, 2 2, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Clin Pathol 58:166-71. 2005
    ..Because the nosological definition and histogenesis of GC remain controversial, the morphology and immunohistochemical staining patterns of neoplastic GC cells were compared with those of other gliomas...
  100. pmc Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion
    Xiaowei Dou
    Veterans Affairs Boston Healthcare System, Department of Neurology, Harvard Medical School, West Roxbury, Massachusetts 02132, USA
    J Biol Chem 286:16131-9. 2011
    ..These findings support the hypothesis that alcohol binding within a pocket bordered by Glu-33 and Tyr-418 inhibits L1 adhesion by disrupting the Ig1-Ig4 interaction...
  101. ncbi Mechanical properties, proteolytic degradability and biological modifications affect angiogenic process extension into native and modified fibrin matrices in vitro
    Lukas Urech
    Department of Material Sciences, Institute for Biomedical Engineering, Federal Institute of Technology and University of Zurich, Moussonstrasse 18, CH 8044 Zurich, Switzerland
    Biomaterials 26:1369-79. 2005
    ....

Research Grants74

  1. L1 SIGNALING IN X-LINKED MENTAL RETARDATION
    Patricia Maness; Fiscal Year: 2000
    ..4. To determine if there are in vivo defects in major axon tracts (corticospinal tract, corpus callosum) in mice with an L1 gene knockout, and in L1/src, L1/fyn and L1/CAM double knockouts. ..
  2. L1 SIGNALING IN X-LINKED MENTAL RETARDATION
    Patricia Maness; Fiscal Year: 1999
    ..4. To determine if there are in vivo defects in major axon tracts (corticospinal tract, corpus callosum) in mice with an L1 gene knockout, and in L1/src, L1/fyn and L1/CAM double knockouts. ..
  3. ALCOHOL INTERACTION WITH L1 CELL ADHESION MOLECULE
    MICHAEL CHARNESS; Fiscal Year: 1999
    ..This knowledge will improve our understanding of the pathogenesis of fetal alcohol syndrome and cognitive disorders in alcoholics, paving the way for more effective prevention and treatment of these disorders. ..
  4. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2009
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Face Page Description, ..
  5. ALCOHOL AND CELL ADHESION
    MICHAEL EDWARD CHARNESS; Fiscal Year: 2010
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Face Page Description, ..
  6. Targeting Pathways of Axonal Cell Adhesion Molecules
    BETTINA R WINCKLER; Fiscal Year: 2010
    ..Since L1 expression is upregulated after neuronal injury and after stroke, understanding L1 trafficking to axons has implications for regenerative processes after injury. ..
  7. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2009
    ..Since L1 expression is upregulated after neuronal injury and after stroke, understanding L1 trafficking to axons has implications for regenerative processes after injury. ..
  8. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    Tanja Godenschwege; Fiscal Year: 2009
    ..This information is essential to find appropriate treatment for the clinical manifestations of these mutations and hence will benefit the health of patients with L1-related disorders in the future. ..
  9. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    Tanja Godenschwege; Fiscal Year: 2009
    ..This information is essential to find appropriate treatment for the clinical manifestations of these mutations and hence will benefit the health of patients with L1-related disorders in the future. ..
  10. FUNCTIONAL ANALYSES OF NEUROGLIAN/L1 IN SYNAPTOGENESIS
    TANJA ANGELA GODENSCHWEGE; Fiscal Year: 2010
    ..This information is essential to find appropriate treatment for the clinical manifestations of these mutations and hence will benefit the health of patients with L1-related disorders in the future. ..
  11. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2009
    ..elegans will define mechanisms that control L1CAM function and provide insights into the physiological mechanism of these disorders, which will help lead to therapeutic development. ..
  12. Molecular Targeting of L1CAM to Inhibit Glioblastoma Stem Cell Invasion
    Shideng Bao; Fiscal Year: 2010
    ..These studies will lay a solid foundation for development of novel, more effective therapeutics against GBM tumor progression and improve the treatment of these lethal cancers. ..
  13. L1 CAM AND MELANOMA PROGRESSION AND ANGIOGENESIS
    Anthony Montgomery; Fiscal Year: 2002
    ..the investigator's abstract) The major objective of this proposal is to define the role of the human neural cell adhesion molecule L1-CAM (L1) in the progression and neovascularization of human malignant melanoma...
  14. Photolabeling of alcohol binding sites L1
    Keith Miller; Fiscal Year: 2003
    ..abstract_text> ..
  15. Photolabeling of alcohol binding sites L1:
    Keith Miller; Fiscal Year: 2004
    ..abstract_text> ..
  16. Photolabeling of alcohol binding sites L1:
    Keith Miller; Fiscal Year: 2005
    ..abstract_text> ..
  17. L1 CAM AND MELANOMA PROGRESSION AND ANGIOGENESIS
    Anthony Montgomery; Fiscal Year: 1999
    ..the investigator's abstract) The major objective of this proposal is to define the role of the human neural cell adhesion molecule L1-CAM (L1) in the progression and neovascularization of human malignant melanoma...
  18. L1 CAM AND MELANOMA PROGRESSION AND ANGIOGENESIS
    Anthony Montgomery; Fiscal Year: 2000
    ..the investigator's abstract) The major objective of this proposal is to define the role of the human neural cell adhesion molecule L1-CAM (L1) in the progression and neovascularization of human malignant melanoma...
  19. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2002
    DESCRIPTION (From the Applicant's Abstract): The neural cell adhesion molecule L1 is found on some classes of migrating neuronal precursors in the developing nervous system and on almost all projection axons in both the central nervous ..
  20. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2003
    DESCRIPTION (From the Applicant's Abstract): The neural cell adhesion molecule L1 is found on some classes of migrating neuronal precursors in the developing nervous system and on almost all projection axons in both the central nervous ..
  21. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2004
    DESCRIPTION (From the Applicant's Abstract): The neural cell adhesion molecule L1 is found on some classes of migrating neuronal precursors in the developing nervous system and on almost all projection axons in both the central nervous ..
  22. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2003
    DESCRIPTION (From the Applicant's Abstract): The neural cell adhesion molecule L1 is found on some classes of migrating neuronal precursors in the developing nervous system and on almost all projection axons in both the central nervous ..
  23. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2005
    DESCRIPTION (From the Applicant's Abstract): The neural cell adhesion molecule L1 is found on some classes of migrating neuronal precursors in the developing nervous system and on almost all projection axons in both the central nervous ..
  24. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2001
    DESCRIPTION (From the Applicant's Abstract): The neural cell adhesion molecule L1 is found on some classes of migrating neuronal precursors in the developing nervous system and on almost all projection axons in both the central nervous ..
  25. SUBCELLULAR MECHANISMS OF PLATELET FUNCTION
    Lawrence Brass; Fiscal Year: 2003
    ..Taken together, the proposed studies should provide new insights into the late events of platelet activation, an area of investigation that is relatively unexplored. ..
  26. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2007
    ..A major goal of the proposed research is to identify compounds that reduce the teratogenic effects of ethanol. ..
  27. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2006
    ..A major goal of the proposed research is to identify compounds that reduce the teratogenic effects of ethanol. ..
  28. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2001
    ..A major goal of the proposed research is to identify compounds that reduce the teratogenic effects of ethanol. ..
  29. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2005
    ..A major goal of the proposed research is to identify compounds that reduce the teratogenic effects of ethanol. ..
  30. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2003
    ..A major goal of the proposed research is to identify compounds that reduce the teratogenic effects of ethanol. ..
  31. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2004
    ..A major goal of the proposed research is to identify compounds that reduce the teratogenic effects of ethanol. ..
  32. ALCOHOL AND CELL ADHESION
    MICHAEL CHARNESS; Fiscal Year: 2002
    ..A major goal of the proposed research is to identify compounds that reduce the teratogenic effects of ethanol. ..
  33. INTERACTION/CELL SURFACE PROTEIN--VERTEBRATE DEVELOPMENT
    Paul Goetinck; Fiscal Year: 1990
    ..With this facility we will be able to record, store and process images of cells behaving under defined conditions and evaluate changes in their shape and motility as a response to other cells or their extracellular matrix...
  34. MOLECULAR DISSECTION OF THE NILE GLYCOPROTEIN
    William Stallcup; Fiscal Year: 1999
    ....
  35. MOLECULAR GENETICS OF HYDROCEPHALUS
    Aravinda Chakravarti; Fiscal Year: 2000
    ..These studies, taken together, will shed light on new pathways that affect early brain development, pathways which when compromised lead to hydrocephalus. ..
  36. MOLECULAR GENETICS OF HYDROCEPHALUS
    Aravinda Chakravarti; Fiscal Year: 1999
    ..These studies, taken together, will shed light on new pathways that affect early brain development, pathways which when compromised lead to hydrocephalus. ..
  37. CAM TARGETING /SIGNALING--FETAL ALCOHOL SYNDROME MODEL?
    DEANNA BENSON; Fiscal Year: 2003
    ..periods. ..
  38. CAM TARGETING /SIGNALING--FETAL ALCOHOL SYNDROME MODEL?
    DEANNA BENSON; Fiscal Year: 2001
    ..periods. ..
  39. CYTOLOGICAL STUDIES OF DEVELOPING AND MATURE NEURONS
    RICHARD BUNGE; Fiscal Year: 1993
    ..The potential of this cell to influence axonal regeneration as well as to repair demyelination gives this work considerable urgency...
  40. CAM TARGETING /SIGNALING--FETAL ALCOHOL SYNDROME MODEL?
    DEANNA BENSON; Fiscal Year: 2002
    ..periods. ..
  41. RETINAL GANGLION CELL AXON-TARGET INTERACTIONS
    Mark Hankin; Fiscal Year: 1993
    ....
  42. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2006
    ..The overall goal of our work is to specify the mechanisms producing the polarized architecture of neurons. [unreadable] [unreadable]..
  43. Mechanisms of Axon Outgrowth and Targeting
    DEANNA BENSON; Fiscal Year: 2007
    ..Results from this work will inform the analysis and interpretation of an in vivo study of ERM function in the regulation of axon outgrowth and branching. ..
  44. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2007
    ..The overall goal of our work is to specify the mechanisms producing the polarized architecture of neurons. [unreadable] [unreadable]..
  45. Mechanisms of Axon Outgrowth and Targeting
    DEANNA BENSON; Fiscal Year: 2009
    ..Results from this work will inform the analysis and interpretation of an in vivo study of ERM function in the regulation of axon outgrowth and branching. ..
  46. Mechanisms of Axon Outgrowth and Targeting
    Deanna L Benson; Fiscal Year: 2010
    ..Results from this work will inform the analysis and interpretation of an in vivo study of ERM function in the regulation of axon outgrowth and branching. ..
  47. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2004
    ..The overall goal of our work is to specify the mechanisms producing the polarized architecture of neurons. ..
  48. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2003
    ..The overall goal of our work is to specify the mechanisms producing the polarized architecture of neurons. ..
  49. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2004
    ..The overall goal of our work is to specify the mechanisms producing the polarized architecture of neurons. ..
  50. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2005
    ..The overall goal of our work is to specify the mechanisms producing the polarized architecture of neurons. ..
  51. REGULATION OF PLATELET AND ENDOTHELIAL CELL FUNCTION
    JOEL BENNETT; Fiscal Year: 2004
    ..The five projects are supported by core facilities for the production of monoclonal antibodies and for the overall administration of the Program. ..
  52. REGULATION OF PLATELET AND ENDOTHELIAL CELL FUNCTION
    JOEL BENNETT; Fiscal Year: 2007
    ..The five projects are supported by core facilities for the production of monoclonal antibodies and for the overall administration of the Program. ..
  53. REGULATION OF PLATELET AND ENDOTHELIAL CELL FUNCTION
    JOEL BENNETT; Fiscal Year: 2003
    ..The five projects are supported by core facilities for the production of monoclonal antibodies and for the overall administration of the Program. ..
  54. REGULATION OF PLATELET AND ENDOTHELIAL CELL FUNCTION
    JOEL BENNETT; Fiscal Year: 2005
    ..The five projects are supported by core facilities for the production of monoclonal antibodies and for the overall administration of the Program. ..
  55. REGULATION OF PLATELET AND ENDOTHELIAL CELL FUNCTION
    JOEL BENNETT; Fiscal Year: 2006
    ..The five projects are supported by core facilities for the production of monoclonal antibodies and for the overall administration of the Program. ..
  56. The Role of Lipid Rafts in Fetal Alcohol Spectrum Disorder
    CYNTHIA FRANCES BEARER; Fiscal Year: 2010
    ..The relevance of this research is that simple dietary manipulations with these nutrients may prevent some aspects of ethanol neurotoxicity much like folic acid supplementation and reduction of neural tube defects. ..
  57. The Role of Lipid Rafts in Fetal Alcohol Spectrum Disorder
    Cynthia Bearer; Fiscal Year: 2007
    ..The relevance of this research is that simple dietary manipulations with these nutrients may prevent some aspects of ethanol neurotoxicity much like folic acid supplementation and reduction of neural tube defects. ..
  58. The Role of Lipid Rafts in Fetal Alcohol Spectrum Disorder
    Cynthia Bearer; Fiscal Year: 2009
    ..The relevance of this research is that simple dietary manipulations with these nutrients may prevent some aspects of ethanol neurotoxicity much like folic acid supplementation and reduction of neural tube defects. ..
  59. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2005
    ..Achieving the aims of this proposal will allow us to better understand how LICAMs mediate their functions. This in turn, will help us in genetic therapy development for L1CAM-related neurological disorders. ..
  60. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2007
    ..Achieving the aims of this proposal will allow us to better understand how LICAMs mediate their functions. This in turn, will help us in genetic therapy development for L1CAM-related neurological disorders. ..
  61. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2006
    ..Achieving the aims of this proposal will allow us to better understand how LICAMs mediate their functions. This in turn, will help us in genetic therapy development for L1CAM-related neurological disorders. ..
  62. Axons and the extracellular matrix in spinal cord injury
    LYN JAKEMAN; Fiscal Year: 2005
    ..abstract_text> ..
  63. Elimination of Carcinogen-Induced Tumor Stem Cells by ATF5 Loss of Function.
    JAMES ANGELASTRO; Fiscal Year: 2008
    ..Thus, ATF5 may be a potential target for therapeutic intervention and a possible treatment for brain cancer. ..
  64. EXPRESSION OF PP60C-SRC IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 1992
    ....
  65. Regulation of Signal Transduction on Vesicles
    Hung Teh Kao; Fiscal Year: 2005
    ..The results will contribute not only to a better understanding of the molecular basis of neural development, but could also provide insights into the pharmacological treatment of neuropsychiatric diseases. ..
  66. Recognition Molecules in Cortical Development
    Patricia Maness; Fiscal Year: 2007
    ..This investigation can reveal new molecular determinants and novel mechanisms governing cortical area development and provide insight into the pathology associated with mental retardation. ..
  67. GABAergic Circuits Critical period in Visual Cortex
    Z Huang; Fiscal Year: 2001
    ..abstract_text> ..