cell adhesion molecules

Summary

Summary: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.

Top Publications

  1. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
  2. ncbi MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer
    Guohong Hu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 15:9-20. 2009
  3. ncbi Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 10:1081-8. 2009
  4. ncbi EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:1451-61. 2008
  5. ncbi Cell adhesion molecules: role and clinical significance in cancer
    Nektaria Makrilia
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Greece
    Cancer Invest 27:1023-37. 2009
  6. ncbi Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment
    Tanja Hochstrasser
    Department of General and Social Psychiatry, Innsbruck Medical University, Austria
    Exp Gerontol 45:70-4. 2010
  7. ncbi Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility
    Lindsay Gillan
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Res 62:5358-64. 2002
  8. ncbi Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses
    Jooyeon Woo
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea
    Nat Neurosci 12:428-37. 2009
  9. ncbi Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals
    Pierre Yves Lozach
    Unite d Immunologie Virale, Institut Pasteur Paris, 25 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:23698-708. 2005
  10. ncbi Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues
    Russell A Norris
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Cell Biochem 101:695-711. 2007

Research Grants

  1. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
  2. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2009
  3. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2010
  4. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2011
  5. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2010
  6. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2005
  7. CADHERIN REGULATION OF OSTEOBLAST FUNCTION
    Roberto Civitelli; Fiscal Year: 1999
  8. Biomarkers of Vascular Disease Progression in Type 1 Diabetes Mellitus
    Maria Lopes Virella; Fiscal Year: 2009
  9. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2010
  10. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2010

Detail Information

Publications195 found, 100 shown here

  1. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
    ..Long-range conformational changes couple these functions via allosteric equilibria...
  2. ncbi MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer
    Guohong Hu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 15:9-20. 2009
    ..These findings establish MTDH as an important therapeutic target for simultaneously enhancing chemotherapy efficacy and reducing metastasis risk...
  3. ncbi Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 10:1081-8. 2009
    ..Our study reveals another level of plasticity in tailoring adaptive immunity to pathogens...
  4. ncbi EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:1451-61. 2008
    ....
  5. ncbi Cell adhesion molecules: role and clinical significance in cancer
    Nektaria Makrilia
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Greece
    Cancer Invest 27:1023-37. 2009
    ..Indeed, changes in the expression or function of cell adhesion molecules have been implicated in all steps of tumor progression, including detachment of tumor cells from the ..
  6. ncbi Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment
    Tanja Hochstrasser
    Department of General and Social Psychiatry, Innsbruck Medical University, Austria
    Exp Gerontol 45:70-4. 2010
    ..The aim of the present pilot study was to explore, if different cell adhesion molecules (ICAM-1 and -3, PECAM-1, VCAM-1, P-, L- and E-selectins, E-cadherin), RAGE and CD14 are affected in ..
  7. ncbi Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility
    Lindsay Gillan
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Res 62:5358-64. 2002
    ..We propose PN functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins to support adhesion and migration of ovarian epithelial cells...
  8. ncbi Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses
    Jooyeon Woo
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea
    Nat Neurosci 12:428-37. 2009
    ..Competitive inhibition by soluble LAR reduced NGL-3-induced presynaptic differentiation. These results suggest that the trans-synaptic adhesion between NGL-3 and LAR regulates excitatory synapse formation in a bidirectional manner...
  9. ncbi Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals
    Pierre Yves Lozach
    Unite d Immunologie Virale, Institut Pasteur Paris, 25 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:23698-708. 2005
    ....
  10. ncbi Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues
    Russell A Norris
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Cell Biochem 101:695-711. 2007
    ..Collectively, these data demonstrate for the first time that periostin can regulate collagen I fibrillogenesis and thereby serves as an important mediator of the biomechanical properties of fibrous connective tissues...
  11. ncbi Dscam-mediated cell recognition regulates neural circuit formation
    Daisuke Hattori
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Annu Rev Cell Dev Biol 24:597-620. 2008
    ....
  12. ncbi Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN
    Marein A W P de Jong
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Gen Virol 89:2398-409. 2008
    ..These data strongly suggest that DC-SIGN is a potential target to prevent HSV infection and virus dissemination. Further studies will show whether these interactions are involved in HSV-induced immune suppression...
  13. ncbi Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
    Catherine I Lacayo
    Department of Biochemistry, Stanford University, Stanford, California, United States of America
    PLoS Biol 5:e233. 2007
    ....
  14. ncbi The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin)
    Carl W Davis
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:37183-94. 2006
    ..The location of the N-linked glycosylation sites on a virion determines the types of glycans incorporated, thus controlling viral tropism for CD209-expressing cells...
  15. ncbi Stress, cognitive impairment and cell adhesion molecules
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Swiss Federal Institute of Technology, EPFL, CH 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:917-30. 2004
    ..Recent studies imply that neuronal cell adhesion molecules of the immunoglobulin superfamily--NCAM and L1--are important mediators of the effects of stress on the ..
  16. ncbi Fat and expanded act in parallel to regulate growth through warts
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:20362-7. 2007
    ....
  17. ncbi Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Trends Mol Med 14:12-9. 2008
    ..Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission...
  18. ncbi Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta
    K Horiuchi
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    J Bone Miner Res 14:1239-49. 1999
    ..By Western blot analysis, TGF-beta increased periostin expression in primary osteoblast cells. Together, these data suggest that periostin may play a role in the recruitment and attachment of osteoblast precursors in the periosteum...
  19. ncbi Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    Toru Oka
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Circ Res 101:313-21. 2007
    ..These are the first genetic data detailing the function of Pn in the adult heart as a regulator of cardiac remodeling and hypertrophy...
  20. ncbi Candida albicans Als adhesins have conserved amyloid-forming sequences
    Henry N Otoo
    Department of Biology, Brooklyn College, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Eukaryot Cell 7:776-82. 2008
    ..K(a)/K(s) analysis showed that the amyloid-forming sequences are highly conserved in Als proteins and evolve more slowly than other regions of the proteins. Therefore, amyloid-forming ability itself is conserved in these proteins...
  21. ncbi Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture
    Isao Kii
    Department of Biological Information, Tokyo Institute of Technology, 4259 Midori ku, Nagatsuta, Yokohama 226 8501
    J Biol Chem 285:2028-39. 2010
    ..This study suggests a role for periostin in adaptation of the ECM architecture in the mechanical environment...
  22. ncbi Periostin is up-regulated in high grade and high stage prostate cancer
    Verena Tischler
    Institute for Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    BMC Cancer 10:273. 2010
    ..Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far...
  23. ncbi Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase
    Takumi Maruhashi
    Department of Biological Information, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 285:13294-303. 2010
    ..Thus, we demonstrated that periostin supported BMP-1-mediated proteolytic activation of LOX on the extracellular matrix, which promoted collagen cross-linking...
  24. ncbi Identification of genes conferring resistance to 5-fluorouracil
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 106:12938-43. 2009
    ..Inhibition of AEG-1 might be exploited as a therapeutic strategy along with 5-FU-based combinatorial chemotherapy for HCC, a highly fatal cancer with currently very limited therapeutic options...
  25. ncbi Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Hum Genet 127:383-94. 2010
    ....
  26. ncbi The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
    J Biol Chem 284:35939-50. 2009
    ..Taken together, these results indicate that the matricellular periostin protein is required for Sost inhibition and thereby plays an important role in the determination of bone mass and microstructural in response to loading...
  27. ncbi The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:532-8. 2003
    ..albicans receptor expressed by DC. Together, these results demonstrate that DC-SIGN is an exquisite pathogen-uptake receptor that captures not only viruses but also fungi...
  28. ncbi Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue
    Peng Su
    Department of Pathology, Qilu Hospital, Shandong University School of Medicine, Ji Nan, China
    Diagn Pathol 5:38. 2010
    ....
  29. ncbi The putative invertebrate adaptive immune protein Litopenaeus vannamei Dscam (LvDscam) is the first reported Dscam to lack a transmembrane domain and cytoplasmic tail
    Pin Hsiang Chou
    Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan
    Dev Comp Immunol 33:1258-67. 2009
    ..We discuss how this tail-less, soluble Dscam can still play an active role in alternative adaptive immune response even while its axonal guidance functionality may be impaired...
  30. ncbi Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Clin Invest 119:465-77. 2009
    ..Targeted inhibition of AEG1 might lead to the shutdown of key elemental characteristics of HCC and could lead to an effective therapeutic strategy for HCC...
  31. ncbi Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling
    S G Lee
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 27:1114-21. 2008
    ..Activation of survival pathways may be one mechanism by which AEG-1 exerts its oncogenic properties...
  32. ncbi Nectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D
    M Lopez
    Institute of Cancerology and Immunology, INSERM U119, Marseille, France
    J Virol 74:1267-74. 2000
    ..Binding of wt HSV-1 gD to soluble nectin2 was not detectable. (iv) A major region of nectin2 functional in virus entry mapped to the V domain, located at the N terminus...
  33. ncbi Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway
    Shideng Bao
    The Key Laboratory for Cell Biology and Tumor Cell Engineering, The Ministry of Education of China, The School of Life Sciences, Xiamen University, Fujian 361005, China
    Cancer Cell 5:329-39. 2004
    ..These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer...
  34. ncbi Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer
    Yasusei Kudo
    Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan
    Cancer Res 66:6928-35. 2006
    ..In summary, these findings suggest that periostin plays an important role in the invasion and anchorage-independent growth of HNSCC...
  35. ncbi Endothelial cell adhesion molecules and cancer progression
    Hanako Kobayashi
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Med Chem 14:377-86. 2007
    The role of cell adhesion molecules (CAMs), such as intercellular cell adhesion molecule-1 (ICAM-1), vascular endothelial cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin, has been studied extensively in the process of ..
  36. ncbi Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer
    Alex Soltermann
    Institute for Surgical Pathology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Clin Cancer Res 14:7430-7. 2008
    ....
  37. ncbi Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer
    B S M S Siriwardena
    Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Hiroshima, Japan
    Br J Cancer 95:1396-403. 2006
    ..In summary, these findings suggest that Periostin may promote invasion and angiogenesis in OSCC, and that Periostin can be a strong marker for prediction of metastasis in oral cancer patients...
  38. ncbi Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1
    Miri Yoon
    Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:9221-31. 2003
    ..The sequence of the N terminus determines whether nectin-2 or 3-O-sulfated heparan sulfate, as well as HVEM, can serve as entry/fusion receptors...
  39. ncbi Ezrin, a key component in tumor metastasis
    Kent W Hunter
    Laboratory of Population Genetics, CCR NCI NIH, 41 Library Drive, Bethesda, MD 20892 5060, USA
    Trends Mol Med 10:201-4. 2004
    ....
  40. ncbi The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin
    A Qu
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Structure 4:931-42. 1996
    ..The crystal structure of the CD11a I domain bound to manganese is known. We therefore set out to determine whether this structure changes when the metal ion is altered or removed...
  41. ncbi The role of junctional adhesion molecules in vascular inflammation
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH University Hospital, 52074 Aachen, Germany
    Nat Rev Immunol 7:467-77. 2007
    ..This Review summarizes recent progress and future directions in understanding the role of JAMs as 'gate keepers' in inflammation and vascular pathology...
  42. ncbi In vivo regulation of Yorkie phosphorylation and localization
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:1081-8. 2008
    ..These results identify modulation of subcellular localization as a mechanism of Yki regulation, and establish that this regulation occurs in vivo through multiple sites of Warts-dependent phosphorylation on Yki...
  43. ncbi Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
    M B Calalb
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Mol Cell Biol 15:954-63. 1995
    ..Our results indicate that phosphorylation of FAK by Src (or other Src family kinases) is an important step in the formation of an active signaling complex...
  44. ncbi DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe?
    Elizabeth J Soilleux
    Medical Research Council Cancer Cell Unit, Hutchison M R C Research Centre, Hills Road, Cambridge CB2 2XY, U K
    Clin Sci (Lond) 104:437-46. 2003
    ..Finally, the role of DC-SIGN in pathology, particularly in infective and neoplastic processes, is discussed, followed by speculation about likely future developments in this field...
  45. ncbi Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production
    Milica Pantelic
    Department of Microbiology and Immunology, Division of Infectious Diseases, Walther Oncology Center, Indiana University School of Medicine, MS415E, 635 Barnhill Dr, Indianapolis, Indiana 46202-5120, USA
    Infect Immun 73:4171-9. 2005
    ..Our results suggest that Neisseria gonorrhoeae possesses the ability to suppress antibody production by killing CEACAM1-expressing B cells...
  46. ncbi Targeted glycoproteomic identification of biomarkers for human breast carcinoma
    Karen L Abbott
    Complex Carbohydrate Research Center, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30605, USA
    J Proteome Res 7:1470-80. 2008
    ..These results indicate that lectin enrichment strategies targeting a particular glycan change associated with malignancy can be an effective method of identifying potential biomarkers for breast carcinoma...
  47. ncbi Periostin: novel diagnostic and therapeutic target for cancer
    Y Kudo
    Department of Oral and Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Histol Histopathol 22:1167-74. 2007
    ..This review summarizes the recent understanding of Periostin roles in tumor development and speculates on the usefulness of Periostin as a therapeutic and diagnostic target for cancer...
  48. ncbi Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr
    Leora Gollan
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 157:1247-56. 2002
    An axonal complex of cell adhesion molecules consisting of Caspr and contactin has been found to be essential for the generation of the paranodal axo-glial junctions flanking the nodes of Ranvier...
  49. ncbi JAM-A regulates permeability and inflammation in the intestine in vivo
    Mike G Laukoetter
    Epithelial Pathobiology Research Unit, Department of Pathology, Emory University, Atlanta, GA 30322, USA
    J Exp Med 204:3067-76. 2007
    ..These findings demonstrate a complex role of JAM-A in intestinal homeostasis by regulating epithelial permeability, inflammation, and proliferation...
  50. ncbi Expression of cell adhesion molecules, CD44s and E-cadherin, and microvessel density in invasive micropapillary carcinoma of the breast
    Y Gong
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Histopathology 46:24-30. 2005
    ..b>Cell adhesion molecules, such as CD44 and E-cadherin (Ecad), and angiogenesis are considered important in the invasion and ..
  51. ncbi JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1
    Susumu Hirabayashi
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Cell Biol 23:4267-82. 2003
    ..These findings suggest that JAM4 together with MAGI-1 provides an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells...
  52. ncbi Shaping phenotype, function, and survival of dendritic cells by cytomegalovirus-encoded IL-10
    Martin J Raftery
    Institute of Virology, , Berlin, Germany
    J Immunol 173:3383-91. 2004
    ..Taken together, these findings show potential mechanisms by which cmvIL-10 could assist HCMV to infect DCs and to impair DC function and survival...
  53. ncbi Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc
    Seok Geun Lee
    Department of Urology, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17390-5. 2006
    ....
  54. ncbi Alternative entry receptors for herpes simplex virus and their roles in disease
    Joann M Taylor
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cell Host Microbe 2:19-28. 2007
    ..This study illustrates the value of mutant mice for understanding receptor contributions to disease caused by a human virus...
  55. ncbi Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers
    Jianbo Wang
    Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Cancer Ther 7:280-5. 2008
    ..Therefore, we have identified Trop-2 as an oncogene that has potential as a therapeutic target. Given the restricted expression of Trop-2 in normal tissue, anti-Trop-2 therapeutics would be predicted to have limited toxicity...
  56. ncbi Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model
    Amara C Siva
    Alexion Antibody Technologies, Inc, San Diego, California, USA
    Cancer Res 68:3759-66. 2008
    ..These data provide support for continued evaluation of anti-CDCP1 therapy for potential use in cancer in primary and metastatic disease...
  57. ncbi Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease
    Stefania Vetrano
    Division of Gastroenterology, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, University of Milan, Rozzano, Italy
    Gastroenterology 135:173-84. 2008
    ..Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored...
  58. ncbi Innate signaling by the C-type lectin DC-SIGN dictates immune responses
    Jeroen den Dunnen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, P O Box 7057, 1007 MC Amsterdam, The Netherlands
    Cancer Immunol Immunother 58:1149-57. 2009
    ..In this review we will discuss in detail the current knowledge about DC-SIGN signaling and its implications on immunity...
  59. ncbi Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Curr Biol 19:1112-7. 2009
    ..We propose that Ds regulates Dco-dependent phosphorylation of Fat and Fat-associated proteins to control Fat signaling in growth and PCP...
  60. ncbi Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1
    J Li
    Department of Biochemistry, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, China
    Oncogene 28:3188-96. 2009
    ....
  61. ncbi Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression
    H J Thirkettle
    Uro Oncology Research Group, Cancer Research UK Cambridge Research Institute, Cambridge, UK
    Oncogene 28:3663-70. 2009
    ..Our data suggest one mechanism for cells with altered LYRIC/AEG-1 expression to evade apoptosis and increase cell growth during tumourigenesis through the regulation of PLZF repression...
  62. ncbi Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing
    Takashi Nishiyama
    Department of Biological Information, Tokyo Institute of Technology, Yokohama, Japan
    PLoS ONE 6:e18410. 2011
    ..Matricellular proteins, including periostin, are important for tissue regeneration...
  63. ncbi An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R
    Eun Kyeong Jo
    Molecular Immunology Section, Department of Immunology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 ONN, England, UK
    J Exp Med 201:1733-9. 2005
    ..Our findings therefore indicate that SKAP-55, unlike SKAP-55R, is specifically tailored as an essential component of the inside-out signaling events that couple the TCR to LFA-1 clustering and T cell-APC conjugation...
  64. ncbi The importance of virus-associated host ICAM-1 in human immunodeficiency virus type 1 dissemination depends on the cellular context
    Salim Bounou
    Research Center in Infectious Diseases, CHUL Research Center, and Faculty of Medicine, Laval University, Quebec, Canada
    FASEB J 18:1294-6. 2004
    ..Altogether these data underscore the complexity of factors participating in virus-cell contact and efficient dissemination of HIV-1 to target cells...
  65. ncbi Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling
    Laura M Hoffman
    The Huntsman Cancer Institute and the Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 172:771-82. 2006
    ..We postulate that zyxin cooperates with Ena/VASP proteins and caldesmon to influence integrin-dependent cell motility and actin stress fiber remodeling...
  66. ncbi The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: implications for wound healing
    Sean M Geary
    School of Biomedical Sciences, University of Newcastle, New South Wales, Australia
    Exp Cell Res 314:2165-75. 2008
    ....
  67. ncbi Endothelial cell-T lymphocyte interactions: IP[corrected]-10 stimulates rapid transendothelial migration of human effort but not central memory CD4+ T cells. Requirements for shear stress and adhesion molecules
    Thomas D Manes
    Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, CT, USA
    Transplantation 82:S9-14. 2006
    ..TNF treatment of ECs may be effectively replaced by transduction of vascular cell adhesion molecule-1 or intercellular adhesion molecule-1 but not E-selectin...
  68. ncbi CD154/CD40-mediated expression of CD154 in endothelial cells: consequences for endothelial cell-monocyte interaction
    Andreas H Wagner
    Department of Cardiovascular Physiology, University of Goettingen, Germany
    Arterioscler Thromb Vasc Biol 24:715-20. 2004
    ..Moreover, CD40 stimulation in nonimmune cells, such as endothelial cells, may play an important role in atherogenesis. One gene product that is induced in endothelial cells on exposure to CD154 is CD154 itself...
  69. ncbi alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion
    Nibedita Chattopadhyay
    Division of Nephrology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 163:1351-62. 2003
    ..These findings demonstrate how integrin-based signaling can regulate complex biological responses at multiple levels to determine cell morphology and behavior...
  70. ncbi N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis
    Yang Luo
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Cell Biol 169:29-34. 2005
    ..These findings provide a novel paradigm by which N-cadherin regulates angiogenesis, in part, by controlling VE-cadherin expression at the cell membrane...
  71. ncbi CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity
    Chanchal Sadhu
    ICOS Corporation, 22021 20th Ave, S E, Bothell, WA 98021, USA
    J Leukoc Biol 81:1395-403. 2007
    ..CD11c appeared to contribute predominantly to the sensitization phase and somewhat less to the response to SRBC challenge. This suggests a novel role for CD11c during leukocyte recruitment, antigen uptake, and the survival of APC...
  72. ncbi Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologues
    Klaus Wethmar
    Max Planck Institute for Molecular Biomedicine, Munster, Germany, and Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
    Eur J Immunol 36:2781-94. 2006
    ..Taken together, this study shows that ICAM-2 strongly supports transmigration of immature DC across resting endothelium by interacting with ligands that are distinct from beta2-integrins and DC-SIGN homologues...
  73. ncbi Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migration
    Meghna U Naik
    Department of Biological Sciences, University of Delaware, 329 Wolf Hall, Newark, DE 19716, USA
    Arterioscler Thromb Vasc Biol 23:2165-71. 2003
    ....
  74. ncbi Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking
    Joachim C U Lehmann
    Experimentelle Rheumatologie, Universitätsklinik Charité, Humboldt Universität and Deutsches Rheumaforschungszentrum, Schumannstrasse 21 22, 10117 Berlin, Germany
    J Immunol 171:2588-93. 2003
    ..These results indicate that ICAM-1 and ICAM-2 have redundant functions in lymphocyte recirculation through lymph nodes, but ICAM-1 is unique in supporting migration into inflamed sites and trapping within the lung...
  75. ncbi LFA-1 and VLA-4 involved in human high proliferative potential-endothelial progenitor cells homing to ischemic tissue
    Huaxin Duan
    National Center of Human Stem Cell Research and Engineering, Institute of Human Reproduction and Stem Cell Engineering, Central South University, 87 Xiang Ya Road, Changsha, Hunan, 410008, China
    Thromb Haemost 96:807-15. 2006
    ..These results indicate that LFA-1 andVLA-4 are involved in HPP-EPC homing to ischemic tissues...
  76. ncbi Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin
    Oliver Pabst
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 176:1474-80. 2006
    ..Thus, FTY720 influences lymphocyte homeostasis not only by suppressing lymphocyte egress from lymph nodes but also by facilitating lymphocyte homing across HEV in an integrin-dependent fashion...
  77. ncbi The junctional adhesion molecule-C promotes neutrophil transendothelial migration in vitro and in vivo
    Triantafyllos Chavakis
    Department of Internal Medicine I, University Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    J Biol Chem 279:55602-8. 2004
    ..Thus, JAM-C participates in neutrophil transmigration and thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies...
  78. ncbi Monocyte adhesion to xenogeneic endothelium during laminar flow is dependent on alpha-Gal-mediated monocyte activation
    Mark D Peterson
    Division of Cardiac Surgery, Department of Surgery, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Immunol 174:8072-81. 2005
    ..Thus, activation of monocyte beta(2) integrins by alpha-gal expressed on xenogeneic endothelium provides a mechanism that may explain the dramatic accumulation of monocytes in vivo...
  79. ncbi Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration
    Andrej Khandoga
    Institute for Surgical Research, Ludwig Maximilians University of Munich, Marchioninistr 27, D 81377 Munich, Germany
    Blood 106:725-33. 2005
    ..JAM-A deficiency does not reduce I/R-induced microvascular and hepatocellular necrotic injury, but increases hepatocyte apoptosis, despite attenuation of neutrophil infiltration...
  80. ncbi Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A
    Georg Ostermann
    Department of Cardiovascular Molecular Biology, University Hospital, Aachen, Germany
    Arterioscler Thromb Vasc Biol 25:729-35. 2005
    ..It is unknown whether these functions can be inhibited by soluble forms of JAM-A, whether JAM-A is expressed on atherosclerotic endothelium, and whether it participates in atherogenic recruitment of mononuclear cells...
  81. ncbi Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN
    Kim S C Weber
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Harvard Medical School, Boston, Massachusetts, USA
    Inflammation 28:177-88. 2004
    ..These findings demonstrated that physiologic sialylation of platelet ICAM-2 renders it less able than endothelial ICAM-2 to support adherence of leukocytes...
  82. ncbi Homocysteine at pathophysiological concentrations enhances binding of dendritic cells to endothelial cells mediated by DC-SIGN
    Shan Li
    Department of Cardiology, First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, People s Republic of China
    Int Immunopharmacol 7:1241-50. 2007
    ....
  83. ncbi Hepatocyte growth factor suppresses vascular endothelial growth factor-induced expression of endothelial ICAM-1 and VCAM-1 by inhibiting the nuclear factor-kappaB pathway
    Jeong-Ki Min
    Department of Biochemistry, College of Sciences, Yonsei University, Seoul, Republic of Korea
    Circ Res 96:300-7. 2005
    ..This suggests that combined treatment with HGF and VEGF could be superior to treatment with either factor alone for enhancing therapeutic angiogenesis while avoiding inflammation...
  84. ncbi Cocaine and catecholamines enhance inflammatory cell retention in the coronary circulation of mice by upregulation of adhesion molecules
    Yu Chen
    Cardiovascular Division, Department of Medicine, The Charles A. Dana Research Institute and Harvard-Thorndike Laboratories, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Heart Circ Physiol 288:H2323-31. 2005
    ..These observations may be of significance for the development of preventative and therapeutic approaches to patients with cocaine- or catecholamine-induced myocarditis...
  85. ncbi ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration
    Michael J Allingham
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 179:4053-64. 2007
    ..7 +/- 7.1% and 38.8 +/- 6.5% reduction, respectively). Our results demonstrate that engagement of ICAM-1 by leukocytes results in tyrosine phosphorylation of VE-cadherin, which is required for efficient neutrophil TEM...
  86. ncbi Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses
    R Lever
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London, UK
    Clin Exp Allergy 37:909-17. 2007
    ..Objective The aim of this study was to investigate the anti-inflammatory effects of tectastemizole in models of allergic inflammation...
  87. ncbi DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Postbus 7057, 1007MB Amsterdam, The Netherlands
    Mol Immunol 45:2359-69. 2008
    ..The identification of Le(Y) as the carbohydrate ligand of DC-SIGN in endothelial cells opens new possibilities for the manipulation of DC migration...
  88. ncbi Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway
    Jianfei Qi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    Mol Biol Cell 16:4386-97. 2005
    ..Transendothelial migration was compromised in cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process...
  89. ncbi Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion
    Qinghong Dan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    Life Sci 76:445-59. 2004
    ..The greater AGE-induced changes in the TG SMCs have provided further support for the dependency of such changes on polyol pathway hyperactivity...
  90. ncbi Cellular niches controlling B lymphocyte behavior within bone marrow during development
    Koji Tokoyoda
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Immunity 20:707-18. 2004
    ..Plasma cells again seed CXCL12-expressing cells. We demonstrate the B lymphocyte characteristic location and movement between specific niches within bone marrow during development and suggest that CXCL12 maintains the cells in the niche...
  91. ncbi HEMCAM/CD146 downregulates cell surface expression of beta1 integrins
    S Alais
    UMR CNRS 7622, Universite Pierre et Marie Curie, Paris, France
    J Cell Sci 114:1847-59. 2001
    ..Thus, our data demonstrate that HEMCAM regulates fibroblast adhesion by controlling beta1 integrin expression...
  92. ncbi Molecular characterization of cell substratum attachments in human glial tumors relates to prognostic features
    N Belot
    Laboratory of Histopathology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium
    Glia 36:375-90. 2001
    ..A potential role for the beta 8 integrin subunit in glioma cell substratum attachments is also emphasized...
  93. ncbi Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro
    Jennifer R Allport
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Leukoc Biol 71:821-8. 2002
    ..These results indicate that although neutrophil proteases may play a role in the acute inflammatory response, neutrophil elastase or MMP-9 is not essential for neutrophil transendothelial migration in this murine system...
  94. ncbi Trimeric assembly of the C-terminal region of thrombospondin-1 or thrombospondin-2 is necessary for cell spreading and fascin spike organisation
    Narayanapanicker Anilkumar
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, UK
    J Cell Sci 115:2357-66. 2002
    ..We conclude that trimeric assembly of the highly conserved TSP C-terminal region is necessary for organisation of the fascin-based cytoskeletal structures that are needed for thrombospondin-induced cell motility...
  95. ncbi An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas
    Ignacio Melero
    Gene Therapy Unit, Department of Medicine, University of Navarra School of Medicine, C Irunlarrea, I 31008 Pamplona, Spain
    Cancer Res 62:3167-74. 2002
    ....
  96. ncbi Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses
    S Liu
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 402:676-81. 1999
    ..Thus, the tight association of paxillin with the alpha4 tail leads to distinct biochemical and biological responses to integrin-mediated cell adhesion...
  97. ncbi Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, The Netherlands
    Blood 100:2908-16. 2002
    ..Thus, mSIGNR1, a murine homologue of DC-SIGN, is important in the defense against pathogens and this study will facilitate further investigations into the in vivo function of DC-SIGN and its homologues...
  98. ncbi Ezrin and moesin co-localise with ICAM-1 in brain endothelial cells but are not directly associated
    Ignacio A Romero
    Endothelial and Epithelial Cell Biology Unit, Department of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Brain Res Mol Brain Res 105:47-59. 2002
    ..Together these data suggest that ICAM-1 is not directly associated with ezrin and moesin in brain microvascular endothelial cells...
  99. ncbi Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages
    P W Suen
    Departments of Laboratory Medicine, and Stomatology and Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 112:4067-78. 1999
    ..These data provide biochemical and morphological evidence that the Src-family kinases Hck and Fgr are required for normal integrin-mediated signal transduction in murine macrophages...
  100. ncbi T-lymphocytes modulate the microvascular and inflammatory responses to intestinal ischemia-reperfusion
    Takeharu Shigematsu
    Department of Molecular Cellular Physiology, Center of Excellence in Arthritis Rheumatology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA
    Microcirculation 9:99-109. 2002
    ..T-cells seem to modulate the recruitment of neutrophils that occurs hours after reperfusion as well as the increased albumin extravasation that occurs within minutes after reperfusion...
  101. ncbi Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I
    A Smolenski
    Institut für Klinische Biochemie und Pathobiochemie, Medizinische Universitatsklinik, Wurzburg, Germany
    J Biol Chem 275:25723-32. 2000
    ..These results indicate that cGK I phosphorylation of VASP results in loss of VASP and zyxin from focal adhesions, a response that could contribute to cGK alteration of cytoskeleton-regulated processes such as cell migration...

Research Grants84

  1. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..proteins implicated in acute phase and inflammatory responses including certain cytokines and chemokines, cell adhesion molecules and inflammatory enzymes; several of these molecules are involved in the pathogenesis of atherosclerosis...
  2. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2009
    ..In previous work, we have found that osteoblasts express members of the cadherin superfamily of cell adhesion molecules, in particular cadherin-11 (Cad11) and N-cadherin (Ncad)...
  3. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2010
    ..In previous work, we have found that osteoblasts express members of the cadherin superfamily of cell adhesion molecules, in particular cadherin-11 (Cad11) and N-cadherin (Ncad)...
  4. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2011
    ..A novel family of cell adhesion molecules (CAMs), the Synaptic Cell Adhesion Molecules (SynCAMs), has recently been proposed to mediate the ..
  5. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2010
    ..A novel family of cell adhesion molecules (CAMs), the Synaptic Cell Adhesion Molecules (SynCAMs), has recently been proposed to mediate the ..
  6. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2005
    ..falciparum have activated endothelium with increased expression on endothelium of a number of cell adhesion molecules (CAMs)...
  7. CADHERIN REGULATION OF OSTEOBLAST FUNCTION
    Roberto Civitelli; Fiscal Year: 1999
    ..Osteoblasts express several members of the cadherin family of cell adhesion molecules, which mediate calcium-dependent cell- cell adhesion...
  8. Biomarkers of Vascular Disease Progression in Type 1 Diabetes Mellitus
    Maria Lopes Virella; Fiscal Year: 2009
    ..To accomplish this goal, we are measuring circulating levels of cell adhesion molecules (CAM), IL6, TNF, CRP, PAI-1, and fibrinogen in samples from the DCCT/EDIC cohort, collected ..
  9. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2010
    ..In adherens junctions, the catenins link transmembrane cadherin cell adhesion molecules to the actin-based cytoskeleton, and in desmosomes an analogous protein assembly links cadherins to ..
  10. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2010
    ..In adherens junctions, the catenins link transmembrane cadherin cell adhesion molecules to the actin-based cytoskeleton, and in desmosomes an analogous protein assembly links cadherins to ..
  11. Role of the Tail Domain in Vinculin Function
    Sharon Campbell; Fiscal Year: 2009
    ..linker between transmembrane integrin receptors and the actin cytoskeleton through association with cell adhesion molecules. Release of autoinhibitory head/tail interactions is believed to activate vinculin's function as a ..
  12. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..linker between transmembrane integrin receptors and the actin cytoskeleton through association with cell adhesion molecules. Release of autoinhibitory head/tail interactions is believed to activate vinculin's function as a ..
  13. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 2003
    ..These studies will contribute to our understanding of the physiologically relevant receptors and counterreceptors that define cell-cell interaction during inflammation. ..
  14. Oligodendrocyte Differentiation and Myelin Biogenesis
    Rashmi Bansal; Fiscal Year: 2007
    ..The proposed participation in this regulation of cell adhesion molecules, src-family kinases, and FGF receptor-3 will be investigated. AIM II...
  15. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..Cell contact-dependent communication is often mediated by cell adhesion molecules which often get clustered into macromolecular assemblies called cell junctions...
  16. High-throughput Pipeline for Electron Crystallography
    David L Stokes; Fiscal Year: 2010
    ..context, membrane proteins act as receptors, enzymes, channels, transporters, structural proteins and cell adhesion molecules and, as such, contribute to a wide variety of essential cellular functions...
  17. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2003
    ..amino acid sequence shows significant homology to a mouse junctional adhesion molecule and to other cell adhesion molecules belonging to the Ig superfamily...
  18. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2009
    ..are secreted (such as immunoglobulins and polypeptide hormones) or present at the cell surface (including cell adhesion molecules and signaling receptors) are produced and folded by the endoplasmic reticulum (ER)...
  19. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2003
    ..is to test the hypothesis that sodium channel beta subunits communicate between extracellular matrix or cell adhesion molecules and the neuronal cytoskeleton...
  20. N-Glycosylation And ER Stress
    MARK ANDREW LEHRMAN; Fiscal Year: 2010
    ..are secreted (such as immunoglobulins and polypeptide hormones) or present at the cell surface (including cell adhesion molecules and signaling receptors) are produced and folded by the endoplasmic reticulum (ER)...
  21. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2009
    ..Since L1 expression is upregulated after neuronal injury and after stroke, understanding L1 trafficking to axons has implications for regenerative processes after injury. ..
  22. Regulation of Placental-Fetal Development During Primate Pregnancy
    Eugene D Albrecht; Fiscal Year: 2010
    ..e. integrins, and cell adhesion molecules (CAM) and matrix metalloproteinases(MMP), has been shown in vitro to play an important role in vascular ..
  23. Targeting Pathways of Axonal Cell Adhesion Molecules
    BETTINA R WINCKLER; Fiscal Year: 2010
    ..Since L1 expression is upregulated after neuronal injury and after stroke, understanding L1 trafficking to axons has implications for regenerative processes after injury. ..
  24. REGULATION OF NEURONAL MOTILITY
    Paul Forscher; Fiscal Year: 2006
    ..these receptors interact with extracellular components that may serve as spatial cues, others recognize cell adhesion molecules (CAMs) on other cells and still other receptors respond to diffusable chemotropic signals...
  25. Regulation of Placental-Fetal Development During Primate Pregnancy
    EUGENE ALBRECHT; Fiscal Year: 2007
    ..e. integrins, and cell adhesion molecules (CAM) and matrix metalloproteinases(MMP), has been shown in vitro to play an important role in vascular ..
  26. Stage-Specific Germ Cell-Sertoli Cell Interactions
    William Wright; Fiscal Year: 2007
    ..Sertoli cells express genes encoding cell adhesion molecules, growth factors, transport proteins, proteases and protease inhibitors required by male germ cells...
  27. Glycoside Inhibitors of Tumor Metastasis
    Jeffrey Esko; Fiscal Year: 2007
    ..sLe x) on cell surface glycoconjugates, sLe x constitutes part of the carbohydrate ligand recognized by cell adhesion molecules belonging to the family of selectin receptors on platelets, leukocytes, and endothelial cells, sLe x-..
  28. Glycoside Inhibitors of Tumor Metastasis
    Jeffrey Esko; Fiscal Year: 2009
    ..sLe x) on cell surface glycoconjugates, sLe x constitutes part of the carbohydrate ligand recognized by cell adhesion molecules belonging to the family of selectin receptors on platelets, leukocytes, and endothelial cells, sLe x-..