cell adhesion molecules

Summary

Summary: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.

Top Publications

  1. doi Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment
    Tanja Hochstrasser
    Department of General and Social Psychiatry, Innsbruck Medical University, Austria
    Exp Gerontol 45:70-4. 2010
  2. pmc Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Cell Stem Cell 5:54-63. 2009
  3. pmc EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Gastroenterology 136:1012-24. 2009
  4. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
  5. doi EpCAM in carcinogenesis: the good, the bad or the ugly
    Bernardina T F van der Gun
    Epigenetic Editing, Department of Medical Biology, University Medical Centre Groningen, Hanzeplein 1, Groningen, TheNetherlands
    Carcinogenesis 31:1913-21. 2010
  6. doi Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 10:1081-8. 2009
  7. doi The emerging role of EpCAM in cancer and stem cell signaling
    Markus Munz
    Micromet AG, Munich, Germany
    Cancer Res 69:5627-9. 2009
  8. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
  9. pmc Mycobacteria target DC-SIGN to suppress dendritic cell function
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, 1081 BT Amsterdam, Netherlands
    J Exp Med 197:7-17. 2003
  10. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002

Detail Information

Publications251 found, 100 shown here

  1. doi Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment
    Tanja Hochstrasser
    Department of General and Social Psychiatry, Innsbruck Medical University, Austria
    Exp Gerontol 45:70-4. 2010
    ..The aim of the present pilot study was to explore, if different cell adhesion molecules (ICAM-1 and -3, PECAM-1, VCAM-1, P-, L- and E-selectins, E-cadherin), RAGE and CD14 are affected in ..
  2. pmc Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Cell Stem Cell 5:54-63. 2009
    ..The results suggest that improvements in animal models and patients after i.v. infusions of MSCs are at least in part explained by activation of MSCs to secrete TSG-6...
  3. pmc EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Gastroenterology 136:1012-24. 2009
    ..We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence of hepatic cancer cells with stem/progenitor features...
  4. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
    ..Long-range conformational changes couple these functions via allosteric equilibria...
  5. doi EpCAM in carcinogenesis: the good, the bad or the ugly
    Bernardina T F van der Gun
    Epigenetic Editing, Department of Medical Biology, University Medical Centre Groningen, Hanzeplein 1, Groningen, TheNetherlands
    Carcinogenesis 31:1913-21. 2010
    ..As epigenetic dysregulation underlies aberrant EpCAM expression, we propose epigenetic editing as a novel approach to investigate the biological role of EpCAM, expanding the options for EpCAM as a therapeutic target in cancer...
  6. doi Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 10:1081-8. 2009
    ..Our study reveals another level of plasticity in tailoring adaptive immunity to pathogens...
  7. doi The emerging role of EpCAM in cancer and stem cell signaling
    Markus Munz
    Micromet AG, Munich, Germany
    Cancer Res 69:5627-9. 2009
    ..EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway...
  8. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    ..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
  9. pmc Mycobacteria target DC-SIGN to suppress dendritic cell function
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, 1081 BT Amsterdam, Netherlands
    J Exp Med 197:7-17. 2003
    ..Moreover, we demonstrate that DC-SIGN has a broader pathogen recognition profile than previously shown, suggesting that DC-SIGN may represent a molecular target for clinical intervention in infections other than HIV-1...
  10. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002
    ..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...
  11. ncbi SynCAM, a synaptic adhesion molecule that drives synapse assembly
    Thomas Biederer
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 297:1525-31. 2002
    ....
  12. pmc A core function for p120-catenin in cadherin turnover
    Michael A Davis
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    J Cell Biol 163:525-34. 2003
    ..The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120...
  13. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
    ..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
  14. ncbi Cell adhesion molecules: signalling functions at the synapse
    Matthew B Dalva
    University of Pennsylvania Medical Center, Department of Neuroscience, BRB II III, Room 1114, 421 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Neurosci 8:206-20. 2007
    Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide a mechanical link between cells...
  15. pmc Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus
    Ryan S Noyce
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS Pathog 7:e1002240. 2011
    ..Several strains of measles virus were also shown to use PVRL4 as a receptor. Measles virus infection reduced PVRL4 surface expression in MCF7 cells, a property that is characteristic of receptor-associated viral infections...
  16. pmc Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells
    Kanyan Xiao
    Department of Dermatology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    J Cell Biol 163:535-45. 2003
    ..These results demonstrate that cellular levels of p120ctn function as a set point mechanism that regulates cadherin expression levels, and that a major function of p120ctn is to control cadherin internalization and degradation...
  17. ncbi C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunity 26:605-16. 2007
    ..Thus, this pathway is involved in regulation of adaptive immunity by DCs to bacterial, fungal, and viral pathogens...
  18. pmc DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina
    Peter G Fuerst
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Neuron 64:484-97. 2009
    ..Therefore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic specificity in the mouse retina...
  19. pmc Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
    Takaharu Ichimura
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1657-68. 2008
    ..Thus, KIM-1 is the first nonmyeloid phosphatidylserine receptor identified to our knowledge that transforms epithelial cells into semiprofessional phagocytes...
  20. ncbi Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta
    K Horiuchi
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    J Bone Miner Res 14:1239-49. 1999
    ..By Western blot analysis, TGF-beta increased periostin expression in primary osteoblast cells. Together, these data suggest that periostin may play a role in the recruitment and attachment of osteoblast precursors in the periosteum...
  21. pmc Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells
    Anieta M Sieuwerts
    Department of Medical Oncology, Josephine Nefkens Institute, Cancer Genomics Centre, Rotterdam, The Netherlands
    J Natl Cancer Inst 101:61-6. 2009
    ..New tests that include antibodies that specifically recognize normal-like breast tumor cells but not cells of hematopoietic origin are needed...
  22. ncbi Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
    T Ichimura
    Renal Unit, Medical Services, Massachusetts General Hospital East, Boston, Massachusetts 02129, USA
    J Biol Chem 273:4135-42. 1998
    ..KIM-1 may play an important role in the restoration of the morphological integrity and function to postischemic kidney...
  23. pmc Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells
    I Martinez
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 27:2575-82. 2008
    ..These findings may contribute to a better understanding of the molecular mechanisms involved in cervical carcinogenesis...
  24. doi Epithelial cell adhesion molecule expression (CD326) in cancer: a short review
    Carlo Patriarca
    Dept of Pathology, Azienda Ospedaliera di Melegnano, Milan, Italy
    Cancer Treat Rev 38:68-75. 2012
    ..Further research and clinical studies should unravel EpCAM's complex role in oncological processes, and expand potential therapeutic applications of EpCAM targeted strategies...
  25. pmc Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
    Hosoon Choi
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine at Scott and White, Temple, TX 76502, USA
    Blood 118:330-8. 2011
    ..Because inflammation underlies many pathologic processes, including immune responses, the results may explain the beneficial effects of MSCs and TSG-6 in several disease models...
  26. ncbi Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    Ugo Cavallaro
    Institute of Biochemistry and Genetics, Department of Clincal Biological Sciences, University of Basel Switzerland
    Nat Rev Cancer 4:118-32. 2004
  27. pmc Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway
    Rafael Cubas
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cancer 9:253. 2010
    ..Here, we studied the effects murine Trop2 (mTrop2) exerted on tumor cellular functions and some of the signaling mechanisms activated by this oncogene...
  28. pmc MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer
    Guohong Hu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 15:9-20. 2009
    ..These findings establish MTDH as an important therapeutic target for simultaneously enhancing chemotherapy efficacy and reducing metastasis risk...
  29. pmc Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells
    M C Ryan
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biol 145:1309-23. 1999
    ..These results indicate that laminin 5 has an important role in regulating tissue organization, gene expression, and survival of epithelium...
  30. ncbi Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
    R J Geraghty
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 280:1618-20. 1998
    ..HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system...
  31. pmc In vivo regulation of Yorkie phosphorylation and localization
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:1081-8. 2008
    ..These results identify modulation of subcellular localization as a mechanism of Yki regulation, and establish that this regulation occurs in vivo through multiple sites of Warts-dependent phosphorylation on Yki...
  32. ncbi TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer
    M Kuramochi
    Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Nat Genet 27:427-30. 2001
    ..2. Thus, attenuation of TSLC1 expression occurred in 85% of primary tumors with LOH. Hypermethylation of the TSLC1 promoter would seem to represent the 'second hit' in NSCLC with LOH...
  33. pmc A novel role for p120 catenin in E-cadherin function
    Renee C Ireton
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 159:465-76. 2002
    ..These data reveal a cooperative interaction between p120 and E-cadherin and a novel role for p120 that is likely indispensable in normal cells...
  34. ncbi Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells
    Tomohiko Wakayama
    Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Biol Reprod 76:1081-90. 2007
    ..These findings suggest that the heterophilic binding of PVR to IGSF4A is responsible, at least in part, for the interaction between Sertoli and spermatogenic cells during mouse spermatogenesis...
  35. ncbi Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    F B Gertler
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:227-39. 1996
    ..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
  36. pmc Complementary adhesin function in C. albicans biofilm formation
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York 10032, USA
    Curr Biol 18:1017-24. 2008
    ..Here, we focus on an adherence mechanism that permits biofilm formation by Candida albicans, the major invasive fungal pathogen of humans...
  37. doi Cell adhesion molecules: role and clinical significance in cancer
    Nektaria Makrilia
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Greece
    Cancer Invest 27:1023-37. 2009
    ..Indeed, changes in the expression or function of cell adhesion molecules have been implicated in all steps of tumor progression, including detachment of tumor cells from the ..
  38. doi HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells
    Sonja I Gringhuis
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 11:419-26. 2010
    ..Inhibition of either pathway abrogated replication and prevented HIV-1 transmission. Thus, HIV-1 subverts crucial components of the immune system for replication that might be targeted to prevent infection and dissemination...
  39. pmc An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration
    G D Turner
    Molecular Parasitology Group, John Radcliffe Hospital, Oxford, UK
    Am J Pathol 145:1057-69. 1994
    ..These results suggest that these receptors have a role in sequestration in vivo and indicate that systemic endothelial activation is a feature of fatal malaria...
  40. ncbi EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:1451-61. 2008
    ....
  41. pmc Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission
    Li Wu
    HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Virol 76:5905-14. 2002
    ..While these findings do not discount the role of intercellular contact in facilitating HIV-1 transmission, our in vitro data indicate that DC-SIGN interactions with ICAM-3 do not promote DC-SIGN-mediated virus transmission...
  42. doi Mutations in the gene encoding CADM1 are associated with autism spectrum disorder
    Yu Zhiling
    Department of Pediatrics, Jichi Medical University, 3311 1 Yakushiji, Shimotsukeshi, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 377:926-9. 2008
    ..Our findings provide key support for the unified idea that impaired synaptogenesis underlies the pathogenesis of ASD...
  43. doi Impairment of social and emotional behaviors in Cadm1-knockout mice
    Yuki Takayanagi
    Department of Physiology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    Biochem Biophys Res Commun 396:703-8. 2010
    ....
  44. ncbi Function and histopathology of a cell adhesion molecule TSLC1 in cancer
    Qi lian Liang
    Department of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China
    Cancer Invest 29:107-12. 2011
    ..On the basis of these, we propose that TSLC1 represents a promising biomarker for cancer diagnosis and a potential target for cancer therapy...
  45. pmc CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis
    Hui Liu
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:1379-84. 2011
    ..In addition, the Y734F mutation also eliminated enhanced Src activation. Thus, this work provides molecular mechanisms for the metastasis-enhancing functions of CDCP1...
  46. ncbi SynCAMs organize synapses through heterophilic adhesion
    Adam I Fogel
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 27:12516-30. 2007
    ..They function as cell adhesion molecules and assemble with each other across the synaptic cleft into a specific, transsynaptic SynCAM 1/2 complex...
  47. pmc STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Jen Liou
    Department of Molecular Pharmacology, Stanford University Medical School, California 94305, USA
    Curr Biol 15:1235-41. 2005
    ..Our study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(2+) store depletion to Ca(2+) influx...
  48. pmc Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner
    Vasanthi Avadhanula
    Department of Infectious Diseases, St Jude Children s Research Hospital, Mailstop 320, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Virol 80:1629-36. 2006
    ..These studies highlight the distinct responses of different cell types to viral infection and the need to consider this variation when interpreting studies of the interactions between respiratory cells and viral pathogens...
  49. ncbi Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:575-85. 2000
    ..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
  50. pmc Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 604 Parran Hall, 130 De Soto St, Pittsburgh, PA 15261, USA
    J Virol 82:4793-806. 2008
    ..Thus, the expression of DC-SIGN is essential for productive HHV-8 infection of and replication in B cells...
  51. ncbi Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes
    J Fawcett
    ICRF Laboratories, University of Oxford, UK
    Nature 360:481-4. 1992
    ..ICAM-3 is closely related to ICAM-1, consists of five immunoglobulin domains, and binds LFA-1 through its two N-terminal domains...
  52. pmc Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6
    Virginia Maina
    Research Laboratory in Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    J Leukoc Biol 86:123-32. 2009
    ..The coordinated expression of PTX3 and TSG-6 may play a role in ECM remodeling at sites of inflammation...
  53. pmc Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells
    Tung Ying Lu
    Institute of Cellular and Organismic Biology, Consiglio Nazionale delle Ricerche, Milan 20131, Italy
    J Biol Chem 285:8719-32. 2010
    ..The expression of EpCAM may be regulated by epigenetic mechanisms, and it is strongly associated with the maintenance of the undifferentiated state of hESCs...
  54. doi The multifaceted role of periostin in tumorigenesis
    Kai Ruan
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, China
    Cell Mol Life Sci 66:2219-30. 2009
    ..In this review, aspects related to the function of periostin in tumorigenesis are summarized...
  55. ncbi Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
    Go Takayama
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Allergy Clin Immunol 118:98-104. 2006
    ..We have previously identified the POSTN gene encoding periostin as an IL-4/IL-13-inducible gene in bronchial epithelial cells. Periostin is thought to be an adhesion molecule because it possesses 4 fasciclin I domains...
  56. ncbi Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice
    E Georges-Labouesse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, C U de Strasbourg, France
    Nat Genet 13:370-3. 1996
    ..Our study provides evidence that some forms of epidermolysis bullosa may originate from defects of the alpha 6 gene...
  57. ncbi How C-type lectins detect pathogens
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
    Cell Microbiol 7:481-8. 2005
    ..Moreover, the cross-talk of C-type lectins with other receptors, such as Toll-like receptors, will be discussed, highlighting the emerging model that microbial recognition is based on a complex network of interacting receptors...
  58. ncbi VAP-1: an adhesin and an enzyme
    M Salmi
    MediCity Research Laboratory, Tykistokatu 6A, University of Turku, FIN 20520 Turku, Finland
    Trends Immunol 22:211-6. 2001
    ..Thus, VAP-1 is an ectoenzyme that has inter-related adhesive and enzymatic functions in regulating physiological trafficking and inflammation...
  59. pmc The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development
    Krasimir Slanchev
    Georges Koehler Laboratory, Max Planck Institute of Immunobiology, Freiburg, Germany
    PLoS Genet 5:e1000563. 2009
    ..In addition, EpCAM is required for the interaction of the epithelia with underlying cell layers...
  60. ncbi Neuronal RA175/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM17-like proteases
    Yuko Tanabe
    Division of Development and Differentiation, Department of Human Inherited Metabolic Disease, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi machi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 444:16-21. 2008
    ....
  61. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007
    ....
  62. doi Mucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment
    Ingrid Arijs
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Gastroenterol 106:748-61. 2011
    ..This migration is regulated by cell adhesion molecules (CAMs), and selective antimigration therapies have been developed...
  63. ncbi Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice
    Csaba Fulop
    Section of Connective Tissue Biology, Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Development 130:2253-61. 2003
    ..These results provide clear evidence that TNFIP6 is a key catalyst in the formation of the cumulus extracellular matrix and indispensable for female fertility...
  64. ncbi Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells
    Jaw Wen Chen
    National Yang Ming University School of Medicine, Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China
    Arterioscler Thromb Vasc Biol 23:1559-66. 2003
    ....
  65. doi Relationship between polymorphism of DC-SIGN (CD209) gene and the susceptibility to pulmonary tuberculosis in an eastern Chinese population
    Ruijuan Zheng
    Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
    Hum Immunol 72:183-6. 2011
    ....
  66. ncbi Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility
    Lindsay Gillan
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Res 62:5358-64. 2002
    ..We propose PN functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins to support adhesion and migration of ovarian epithelial cells...
  67. ncbi Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals
    Pierre Yves Lozach
    Unite d Immunologie Virale, Institut Pasteur Paris, 25 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:23698-708. 2005
    ....
  68. pmc Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues
    Russell A Norris
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Cell Biochem 101:695-711. 2007
    ..Collectively, these data demonstrate for the first time that periostin can regulate collagen I fibrillogenesis and thereby serves as an important mediator of the biomechanical properties of fibrous connective tissues...
  69. doi Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses
    Jooyeon Woo
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea
    Nat Neurosci 12:428-37. 2009
    ..Competitive inhibition by soluble LAR reduced NGL-3-induced presynaptic differentiation. These results suggest that the trans-synaptic adhesion between NGL-3 and LAR regulates excitatory synapse formation in a bidirectional manner...
  70. ncbi Stress, cognitive impairment and cell adhesion molecules
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Swiss Federal Institute of Technology, EPFL, CH 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:917-30. 2004
    ..Recent studies imply that neuronal cell adhesion molecules of the immunoglobulin superfamily--NCAM and L1--are important mediators of the effects of stress on the ..
  71. doi Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Hum Genet 127:383-94. 2010
    ....
  72. pmc Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue
    Peng Su
    Department of Pathology, Qilu Hospital, Shandong University School of Medicine, Ji Nan, China
    Diagn Pathol 5:38. 2010
    ....
  73. pmc The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
    J Biol Chem 284:35939-50. 2009
    ..Taken together, these results indicate that the matricellular periostin protein is required for Sost inhibition and thereby plays an important role in the determination of bone mass and microstructural in response to loading...
  74. pmc Periostin is up-regulated in high grade and high stage prostate cancer
    Verena Tischler
    Institute for Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    BMC Cancer 10:273. 2010
    ..Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far...
  75. pmc Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase
    Takumi Maruhashi
    Department of Biological Information, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 285:13294-303. 2010
    ..Thus, we demonstrated that periostin supported BMP-1-mediated proteolytic activation of LOX on the extracellular matrix, which promoted collagen cross-linking...
  76. ncbi The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:532-8. 2003
    ..albicans receptor expressed by DC. Together, these results demonstrate that DC-SIGN is an exquisite pathogen-uptake receptor that captures not only viruses but also fungi...
  77. pmc Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture
    Isao Kii
    Department of Biological Information, Tokyo Institute of Technology, 4259 Midori ku, Nagatsuta, Yokohama 226 8501
    J Biol Chem 285:2028-39. 2010
    ..This study suggests a role for periostin in adaptation of the ECM architecture in the mechanical environment...
  78. doi Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN
    Marein A W P de Jong
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Gen Virol 89:2398-409. 2008
    ..These data strongly suggest that DC-SIGN is a potential target to prevent HSV infection and virus dissemination. Further studies will show whether these interactions are involved in HSV-induced immune suppression...
  79. pmc Dscam-mediated cell recognition regulates neural circuit formation
    Daisuke Hattori
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Annu Rev Cell Dev Biol 24:597-620. 2008
    ....
  80. pmc Candida albicans Als adhesins have conserved amyloid-forming sequences
    Henry N Otoo
    Department of Biology, Brooklyn College, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Eukaryot Cell 7:776-82. 2008
    ..K(a)/K(s) analysis showed that the amyloid-forming sequences are highly conserved in Als proteins and evolve more slowly than other regions of the proteins. Therefore, amyloid-forming ability itself is conserved in these proteins...
  81. pmc Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Clin Invest 119:465-77. 2009
    ..Targeted inhibition of AEG1 might lead to the shutdown of key elemental characteristics of HCC and could lead to an effective therapeutic strategy for HCC...
  82. ncbi Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Trends Mol Med 14:12-9. 2008
    ..Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission...
  83. pmc Fat and expanded act in parallel to regulate growth through warts
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:20362-7. 2007
    ....
  84. pmc Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
    Catherine I Lacayo
    Department of Biochemistry, Stanford University, Stanford, California, United States of America
    PLoS Biol 5:e233. 2007
    ....
  85. pmc Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    Toru Oka
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Circ Res 101:313-21. 2007
    ..These are the first genetic data detailing the function of Pn in the adult heart as a regulator of cardiac remodeling and hypertrophy...
  86. doi The putative invertebrate adaptive immune protein Litopenaeus vannamei Dscam (LvDscam) is the first reported Dscam to lack a transmembrane domain and cytoplasmic tail
    Pin Hsiang Chou
    Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan
    Dev Comp Immunol 33:1258-67. 2009
    ..We discuss how this tail-less, soluble Dscam can still play an active role in alternative adaptive immune response even while its axonal guidance functionality may be impaired...
  87. ncbi The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin)
    Carl W Davis
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:37183-94. 2006
    ..The location of the N-linked glycosylation sites on a virion determines the types of glycans incorporated, thus controlling viral tropism for CD209-expressing cells...
  88. pmc Identification of genes conferring resistance to 5-fluorouracil
    Byoung Kwon Yoo
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 106:12938-43. 2009
    ..Inhibition of AEG-1 might be exploited as a therapeutic strategy along with 5-FU-based combinatorial chemotherapy for HCC, a highly fatal cancer with currently very limited therapeutic options...
  89. ncbi Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling
    S G Lee
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 27:1114-21. 2008
    ..Activation of survival pathways may be one mechanism by which AEG-1 exerts its oncogenic properties...
  90. ncbi DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe?
    Elizabeth J Soilleux
    Medical Research Council Cancer Cell Unit, Hutchison M R C Research Centre, Hills Road, Cambridge CB2 2XY, U K
    Clin Sci (Lond) 104:437-46. 2003
    ..Finally, the role of DC-SIGN in pathology, particularly in infective and neoplastic processes, is discussed, followed by speculation about likely future developments in this field...
  91. doi Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer
    Alex Soltermann
    Institute for Surgical Pathology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Clin Cancer Res 14:7430-7. 2008
    ....
  92. pmc Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer
    B S M S Siriwardena
    Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Hiroshima, Japan
    Br J Cancer 95:1396-403. 2006
    ..In summary, these findings suggest that Periostin may promote invasion and angiogenesis in OSCC, and that Periostin can be a strong marker for prediction of metastasis in oral cancer patients...
  93. pmc Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1
    Miri Yoon
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:9221-31. 2003
    ..The sequence of the N terminus determines whether nectin-2 or 3-O-sulfated heparan sulfate, as well as HVEM, can serve as entry/fusion receptors...
  94. ncbi Endothelial cell adhesion molecules and cancer progression
    Hanako Kobayashi
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Med Chem 14:377-86. 2007
    The role of cell adhesion molecules (CAMs), such as intercellular cell adhesion molecule-1 (ICAM-1), vascular endothelial cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin, has been studied extensively in the process of ..
  95. ncbi Ezrin, a key component in tumor metastasis
    Kent W Hunter
    Laboratory of Population Genetics, CCR NCI NIH, 41 Library Drive, Bethesda, MD 20892 5060, USA
    Trends Mol Med 10:201-4. 2004
    ....
  96. ncbi The role of junctional adhesion molecules in vascular inflammation
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH University Hospital, 52074 Aachen, Germany
    Nat Rev Immunol 7:467-77. 2007
    ..This Review summarizes recent progress and future directions in understanding the role of JAMs as 'gate keepers' in inflammation and vascular pathology...
  97. ncbi Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway
    Shideng Bao
    The Key Laboratory for Cell Biology and Tumor Cell Engineering, The Ministry of Education of China, The School of Life Sciences, Xiamen University, Fujian 361005, China
    Cancer Cell 5:329-39. 2004
    ..These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer...
  98. ncbi Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer
    Yasusei Kudo
    Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan
    Cancer Res 66:6928-35. 2006
    ..In summary, these findings suggest that periostin plays an important role in the invasion and anchorage-independent growth of HNSCC...
  99. ncbi The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin
    A Qu
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Structure 4:931-42. 1996
    ..The crystal structure of the CD11a I domain bound to manganese is known. We therefore set out to determine whether this structure changes when the metal ion is altered or removed...
  100. pmc Nectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D
    M Lopez
    Institute of Cancerology and Immunology, INSERM U119, Marseille, France
    J Virol 74:1267-74. 2000
    ..Binding of wt HSV-1 gD to soluble nectin2 was not detectable. (iv) A major region of nectin2 functional in virus entry mapped to the V domain, located at the N terminus...
  101. pmc Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
    M B Calalb
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Mol Cell Biol 15:954-63. 1995
    ..Our results indicate that phosphorylation of FAK by Src (or other Src family kinases) is an important step in the formation of an active signaling complex...

Research Grants84

  1. Tumor Cell Arrest and Adhesion in the Microcirculation
    Bingmei M Fu; Fiscal Year: 2010
    ..between microcirculation-induced mechanical factors, microvascular permeability (vascular integrity), cell adhesion molecules, nitric oxide and cytokines, and tumor metastasis in intact microvessels...
  2. Biomimetic scaffolds for targeted peripheral nerve regeneration
    DAVID SHREIBER; Fiscal Year: 2009
    ..We have developed peptide mimics of two carbohydrates carried by neural cell adhesion molecules that are important in targeted innervation during development and that promote neuron survival and ..
  3. Biomimetic scaffolds for targeted peripheral nerve regeneration
    DAVID SHREIBER; Fiscal Year: 2009
    ..We have developed peptide mimics of two carbohydrates carried by neural cell adhesion molecules that are important in targeted innervation during development and that promote neuron survival and ..
  4. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 1999
    ..their dissimilar structures, both proteoglycans bind specifically and with high affinity to neural cell adhesion molecules and the extracellular matrix protein tenascin...
  5. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..their dissimilar structures, both proteoglycans bind specifically and with high affinity to neural cell adhesion molecules and the extracellular matrix protein tenascin...
  6. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..proteins implicated in acute phase and inflammatory responses including certain cytokines and chemokines, cell adhesion molecules and inflammatory enzymes; several of these molecules are involved in the pathogenesis of atherosclerosis...
  7. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2001
    ..proteins implicated in acute phase and inflammatory responses including certain cytokines and chemokines, cell adhesion molecules and inflammatory enzymes; several of these molecules are involved in the pathogenesis of atherosclerosis...
  8. Mucus Penetrating Nanoparticles for Vaginal Drug Delivery
    Justin Hanes; Fiscal Year: 2009
    ..If successful, this project could lead to the development of sustained drug delivery systems that are more convenient, and more effective, for preventing and treating diseases than methods now available. ..
  9. Neuroligin Regulation of Central GABAergic Synapses
    Zhanyan Fu; Fiscal Year: 2010
    ..NLs are postsynaptic cell adhesion molecules (CAMs) expressed on the surface of postsynaptic membrane...
  10. Neuroligin Regulation of Central GABAergic Synapses
    Zhanyan Fu; Fiscal Year: 2009
    ..NLs are postsynaptic cell adhesion molecules (CAMs) expressed on the surface of postsynaptic membrane...
  11. Nano-sized Cell Guidance System for Ischemic Tissue Repair
    Hyunjoon Kong; Fiscal Year: 2010
    ..poly(glycerol) linked with both epitopes binding with transplanted cells and those binding with vascular cell adhesion molecules (VCAM)-1 will precisely guide transplanted cells to the injured endothelium because the endothelial ..
  12. Nano-sized Cell Guidance System for Ischemic Tissue Repair
    Hyunjoon Kong; Fiscal Year: 2009
    ..poly(glycerol) linked with both epitopes binding with transplanted cells and those binding with vascular cell adhesion molecules (VCAM)-1 will precisely guide transplanted cells to the injured endothelium because the endothelial ..
  13. ENDOMETRIAL INTEGRINS--A ROLE IN UTERINE RECEPTIVITY
    Bruce Lessey; Fiscal Year: 1992
    ..Preliminary data suggest that integrins, a family of cell adhesion molecules, participate in endometrial structure and function...
  14. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2009
    ..In previous work, we have found that osteoblasts express members of the cadherin superfamily of cell adhesion molecules, in particular cadherin-11 (Cad11) and N-cadherin (Ncad)...
  15. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2010
    ..In previous work, we have found that osteoblasts express members of the cadherin superfamily of cell adhesion molecules, in particular cadherin-11 (Cad11) and N-cadherin (Ncad)...
  16. Migration of polyomavirus JC across the blood-brain-barrier
    Vivek Nerurkar; Fiscal Year: 2009
    ..brain microvascular endothelial (HBMVE) cells or if JCV-infected B cells alter the expression patterns of cell adhesion molecules (CAM), such as very late antigen-4 (VLA-4) and lymphocyte function associated-antigen-1 (LFA-1), and ..
  17. Glutamate receptor recruitment to new synapses in vivo
    Philip Washbourne; Fiscal Year: 2009
    ..A novel family of cell adhesion molecules (CAMs), the Synaptic Cell Adhesion Molecules (SynCAMs), has recently been proposed to mediate the ..
  18. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2011
    ..A novel family of cell adhesion molecules (CAMs), the Synaptic Cell Adhesion Molecules (SynCAMs), has recently been proposed to mediate the ..
  19. Glutamate receptor recruitment to new synapses in vivo
    Philip Washbourne; Fiscal Year: 2009
    ..A novel family of cell adhesion molecules (CAMs), the Synaptic Cell Adhesion Molecules (SynCAMs), has recently been proposed to mediate the ..
  20. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2010
    ..A novel family of cell adhesion molecules (CAMs), the Synaptic Cell Adhesion Molecules (SynCAMs), has recently been proposed to mediate the ..
  21. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2003
    ..falciparum have activated endothelium with increased expression on endothelium of a number of cell adhesion molecules (CAMs)...
  22. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2005
    ..falciparum have activated endothelium with increased expression on endothelium of a number of cell adhesion molecules (CAMs)...
  23. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2004
    ..falciparum have activated endothelium with increased expression on endothelium of a number of cell adhesion molecules (CAMs)...
  24. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2002
    ..falciparum have activated endothelium with increased expression on endothelium of a number of cell adhesion molecules (CAMs)...
  25. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2002
    ..falciparum have activated endothelium with increased expression on endothelium of a number of cell adhesion molecules (CAMs)...
  26. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2001
    ..falciparum have activated endothelium with increased expression on endothelium of a number of cell adhesion molecules (CAMs)...
  27. CADHERIN REGULATION OF OSTEOBLAST FUNCTION
    Roberto Civitelli; Fiscal Year: 1999
    ..Osteoblasts express several members of the cadherin family of cell adhesion molecules, which mediate calcium-dependent cell- cell adhesion...
  28. Biomarkers of Vascular Disease Progression in Type 1 Diabetes Mellitus
    Maria Lopes Virella; Fiscal Year: 2009
    ..To accomplish this goal, we are measuring circulating levels of cell adhesion molecules (CAM), IL6, TNF, CRP, PAI-1, and fibrinogen in samples from the DCCT/EDIC cohort, collected ..
  29. CATENINS, CADHERINS AND THEIR INTERACTIONS
    WILLIAM WEIS; Fiscal Year: 2009
    ..In adherens junctions, the catenins link transmembrane cadherin cell adhesion molecules to the actin-based cytoskeleton, and in desmosomes an analogous protein assembly links cadherins to ..
  30. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2010
    ..In adherens junctions, the catenins link transmembrane cadherin cell adhesion molecules to the actin-based cytoskeleton, and in desmosomes an analogous protein assembly links cadherins to ..
  31. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2010
    ..In adherens junctions, the catenins link transmembrane cadherin cell adhesion molecules to the actin-based cytoskeleton, and in desmosomes an analogous protein assembly links cadherins to ..
  32. Role of the Tail Domain in Vinculin Function
    Sharon Campbell; Fiscal Year: 2009
    ..linker between transmembrane integrin receptors and the actin cytoskeleton through association with cell adhesion molecules. Release of autoinhibitory head/tail interactions is believed to activate vinculin's function as a ..
  33. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..linker between transmembrane integrin receptors and the actin cytoskeleton through association with cell adhesion molecules. Release of autoinhibitory head/tail interactions is believed to activate vinculin's function as a ..
  34. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 2003
    ..These studies will contribute to our understanding of the physiologically relevant receptors and counterreceptors that define cell-cell interaction during inflammation. ..
  35. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 2001
    ..These studies will contribute to our understanding of the physiologically relevant receptors and counterreceptors that define cell-cell interaction during inflammation. ..
  36. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 2002
    ..These studies will contribute to our understanding of the physiologically relevant receptors and counterreceptors that define cell-cell interaction during inflammation. ..
  37. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 2000
    ..These studies will contribute to our understanding of the physiologically relevant receptors and counterreceptors that define cell-cell interaction during inflammation. ..
  38. Cell adhesion and photoreceptor morphogenesis in the retina
    Marek Mlodzik; Fiscal Year: 2009
    ..this precise arrangement requires the interplay of several signaling pathways, transcription factors, and cell adhesion molecules. These are conserved and share equivalent functions in the mammalian eye...
  39. Oligodendrocyte Differentiation and Myelin Biogenesis
    Rashmi Bansal; Fiscal Year: 2007
    ..The proposed participation in this regulation of cell adhesion molecules, src-family kinases, and FGF receptor-3 will be investigated. AIM II...
  40. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2005
    ..Cell contact-dependent communication is often mediated by cell adhesion molecules which often get clustered into macromolecular assemblies called cell junctions...
  41. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..Cell contact-dependent communication is often mediated by cell adhesion molecules which often get clustered into macromolecular assemblies called cell junctions...
  42. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2007
    ..Cell contact-dependent communication is often mediated by cell adhesion molecules which often get clustered into macromolecular assemblies called cell junctions...
  43. High-throughput Pipeline for Electron Crystallography
    David L Stokes; Fiscal Year: 2010
    ..context, membrane proteins act as receptors, enzymes, channels, transporters, structural proteins and cell adhesion molecules and, as such, contribute to a wide variety of essential cellular functions...
  44. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2006
    ..Cell contact-dependent communication is often mediated by cell adhesion molecules which often get clustered into macromolecular assemblies called cell junctions...
  45. Identification of Autism genes that regulate synaptic Nrx/Nlg signaling complexes
    Craig C Garner; Fiscal Year: 2010
    ..function to regulate the formation of complexes between two key synaptic proteins, the transsynaptic cell adhesion molecules Neurexin and Neuroligin, which in turn mediate the maturation, function, and plasticity of excitatory ..
  46. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2002
    ..amino acid sequence shows significant homology to a mouse junctional adhesion molecule and to other cell adhesion molecules belonging to the Ig superfamily...
  47. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2000
    ..amino acid sequence shows significant homology to a mouse junctional adhesion molecule and to other cell adhesion molecules belonging to the Ig superfamily...
  48. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2003
    ..amino acid sequence shows significant homology to a mouse junctional adhesion molecule and to other cell adhesion molecules belonging to the Ig superfamily...
  49. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2001
    ..amino acid sequence shows significant homology to a mouse junctional adhesion molecule and to other cell adhesion molecules belonging to the Ig superfamily...
  50. Sexual development of the Drosophila gonad
    Mark Van Doren; Fiscal Year: 2009
    ..We will investigate whether these cell-cell adhesion molecules are important for morphogenesis of the niche and for regulating the behavior of the germline stem cells...
  51. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2009
    ..are secreted (such as immunoglobulins and polypeptide hormones) or present at the cell surface (including cell adhesion molecules and signaling receptors) are produced and folded by the endoplasmic reticulum (ER)...
  52. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2003
    ..is to test the hypothesis that sodium channel beta subunits communicate between extracellular matrix or cell adhesion molecules and the neuronal cytoskeleton...
  53. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2001
    ..is to test the hypothesis that sodium channel beta subunits communicate between extracellular matrix or cell adhesion molecules and the neuronal cytoskeleton...
  54. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2002
    ..is to test the hypothesis that sodium channel beta subunits communicate between extracellular matrix or cell adhesion molecules and the neuronal cytoskeleton...
  55. N-Glycosylation And ER Stress
    MARK ANDREW LEHRMAN; Fiscal Year: 2010
    ..are secreted (such as immunoglobulins and polypeptide hormones) or present at the cell surface (including cell adhesion molecules and signaling receptors) are produced and folded by the endoplasmic reticulum (ER)...
  56. SENSORY AXON PATHFINDING
    MARCIA HONIG; Fiscal Year: 1999
    ..The proposed studies will examine how various cell adhesion molecules (CAMs), expressed on the surfaces of sensory and motoneuron axons, influence the interactions that occur ..
  57. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2000
    ..is to test the hypothesis that sodium channel beta subunits communicate between extracellular matrix or cell adhesion molecules and the neuronal cytoskeleton...
  58. REGULATION OF NEURONAL MOTILITY
    Paul Forscher; Fiscal Year: 2004
    ..these receptors interact with extracellular components that may serve as spatial cues, others recognize cell adhesion molecules (CAMs) on other cells and still other receptors respond to diffusable chemotropic signals...
  59. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2009
    ..Since L1 expression is upregulated after neuronal injury and after stroke, understanding L1 trafficking to axons has implications for regenerative processes after injury. ..
  60. REGULATION OF NEURONAL MOTILITY
    Paul Forscher; Fiscal Year: 2003
    ..these receptors interact with extracellular components that may serve as spatial cues, others recognize cell adhesion molecules (CAMs) on other cells and still other receptors respond to diffusable chemotropic signals...
  61. Regulation of Placental-Fetal Development During Primate Pregnancy
    Eugene D Albrecht; Fiscal Year: 2010
    ..e. integrins, and cell adhesion molecules (CAM) and matrix metalloproteinases(MMP), has been shown in vitro to play an important role in vascular ..
  62. Targeting Pathways of Axonal Cell Adhesion Molecules
    BETTINA R WINCKLER; Fiscal Year: 2010
    ..Since L1 expression is upregulated after neuronal injury and after stroke, understanding L1 trafficking to axons has implications for regenerative processes after injury. ..
  63. REGULATION OF NEURONAL MOTILITY
    Paul Forscher; Fiscal Year: 2006
    ..these receptors interact with extracellular components that may serve as spatial cues, others recognize cell adhesion molecules (CAMs) on other cells and still other receptors respond to diffusable chemotropic signals...
  64. Regulation of Placental-Fetal Development During Primate Pregnancy
    EUGENE ALBRECHT; Fiscal Year: 2007
    ..e. integrins, and cell adhesion molecules (CAM) and matrix metalloproteinases(MMP), has been shown in vitro to play an important role in vascular ..
  65. REGULATION OF NEURONAL MOTILITY
    Paul Forscher; Fiscal Year: 2002
    ..these receptors interact with extracellular components that may serve as spatial cues, others recognize cell adhesion molecules (CAMs) on other cells and still other receptors respond to diffusable chemotropic signals...
  66. REGULATION OF NEURONAL MOTILITY
    Paul Forscher; Fiscal Year: 2005
    ..these receptors interact with extracellular components that may serve as spatial cues, others recognize cell adhesion molecules (CAMs) on other cells and still other receptors respond to diffusable chemotropic signals...
  67. Regulation of Placental-Fetal Development During Primate Pregnancy
    EUGENE ALBRECHT; Fiscal Year: 2009
    ..e. integrins, and cell adhesion molecules (CAM) and matrix metalloproteinases(MMP), has been shown in vitro to play an important role in vascular ..
  68. Stage-Specific Germ Cell-Sertoli Cell Interactions
    William Wright; Fiscal Year: 2004
    ..Sertoli cells express genes encoding cell adhesion molecules, growth factors, transport proteins, proteases and protease inhibitors required by male germ cells...
  69. Stage-Specific Germ Cell-Sertoli Cell Interactions
    William Wright; Fiscal Year: 2007
    ..Sertoli cells express genes encoding cell adhesion molecules, growth factors, transport proteins, proteases and protease inhibitors required by male germ cells...
  70. Stage-Specific Germ Cell-Sertoli Cell Interactions
    William Wright; Fiscal Year: 2005
    ..Sertoli cells express genes encoding cell adhesion molecules, growth factors, transport proteins, proteases and protease inhibitors required by male germ cells...
  71. Structural Analysis of Reovirus Attachment Mechanisms
    Terence Dermody; Fiscal Year: 2009
    ..This work will contribute important new information about how viruses select cellular targets and aid in the development of new antiviral vaccines and therapeutics. ..
  72. Stage-Specific Germ Cell-Sertoli Cell Interactions
    William Wright; Fiscal Year: 2006
    ..Sertoli cells express genes encoding cell adhesion molecules, growth factors, transport proteins, proteases and protease inhibitors required by male germ cells...
  73. Stage-Specific Germ Cell-Sertoli Cell Interactions
    William Wright; Fiscal Year: 2003
    ..Sertoli cells express genes encoding cell adhesion molecules, growth factors, transport proteins, proteases and protease inhibitors required by male germ cells...
  74. FUNCTIONS OF CADHERINS IN EPITHELIAL BIOGENESIS
    Barry Gumbiner; Fiscal Year: 1992
    The cadherins are Ca2+ dependent cell adhesion molecules important for the biogenesis of polarized epithelia and for the morphogenesis of epithelial tissues during embryonic development...
  75. MOLECULAR SIGNALS FOR GRANULOMA FORMATION
    James McKerrow; Fiscal Year: 1999
    ..that are important to granuloma formation results from interactions between immune cells and endothelial cell adhesion molecules that localize inflammatory cells at the site of egg deposition...
  76. MOLECULAR SIGNALS FOR GRANULOMA FORMATION
    James McKerrow; Fiscal Year: 2000
    ..that are important to granuloma formation results from interactions between immune cells and endothelial cell adhesion molecules that localize inflammatory cells at the site of egg deposition...
  77. CELL ADHESION MOLECULES IN NEURAL CREST ONTOGENY
    Marianne Bronner Fraser; Fiscal Year: 1991
    The longterm goals of this proposal are to establish the role of cell adhesion molecules in initiation of migration and in the formation of neural crest-derived ganglia...
  78. Glycoside Inhibitors of Tumor Metastasis
    Jeffrey Esko; Fiscal Year: 2007
    ..sLe x) on cell surface glycoconjugates, sLe x constitutes part of the carbohydrate ligand recognized by cell adhesion molecules belonging to the family of selectin receptors on platelets, leukocytes, and endothelial cells, sLe x-..
  79. Glycoside Inhibitors of Tumor Metastasis
    Jeffrey Esko; Fiscal Year: 2006
    ..sLe x) on cell surface glycoconjugates, sLe x constitutes part of the carbohydrate ligand recognized by cell adhesion molecules belonging to the family of selectin receptors on platelets, leukocytes, and endothelial cells, sLe x-..
  80. Glycoside Inhibitors of Tumor Metastasis
    Jeffrey Esko; Fiscal Year: 2009
    ..sLe x) on cell surface glycoconjugates, sLe x constitutes part of the carbohydrate ligand recognized by cell adhesion molecules belonging to the family of selectin receptors on platelets, leukocytes, and endothelial cells, sLe x-..
  81. Glycoside Inhibitors of Tumor Metastasis
    Jeffrey Esko; Fiscal Year: 2005
    ..sLe x) on cell surface glycoconjugates, sLe x constitutes part of the carbohydrate ligand recognized by cell adhesion molecules belonging to the family of selectin receptors on platelets, leukocytes, and endothelial cells, sLe x-..