cell adhesion molecules

Summary

Summary: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.

Top Publications

  1. pmc Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Cell Stem Cell 5:54-63. 2009
  2. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
  3. pmc Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
    Hosoon Choi
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine at Scott and White, Temple, TX 76502, USA
    Blood 118:330-8. 2011
  4. ncbi Interactions between cancer stem cells and their niche govern metastatic colonization
    Ilaria Malanchi
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research Molecular Oncology, 1015 Lausanne, Switzerland
    Nature 481:85-9. 2012
  5. ncbi EpCAM in carcinogenesis: the good, the bad or the ugly
    Bernardina T F van der Gun
    Epigenetic Editing, Department of Medical Biology, University Medical Centre Groningen, Hanzeplein 1, Groningen, TheNetherlands
    Carcinogenesis 31:1913-21. 2010
  6. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
  7. pmc EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Gastroenterology 136:1012-24. 2009
  8. ncbi Frequent EpCam protein expression in human carcinomas
    Philip Th Went
    Institute for Pathology, University of Basel, Basel, Switzerland
    Hum Pathol 35:122-8. 2004
  9. pmc MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer
    Guohong Hu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 15:9-20. 2009
  10. ncbi Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival
    Jun Li
    Key Laboratory of Tropical Disease Control Sun Yat sen University, Ministry of Education, Guangzhou, Guangdong, China
    Clin Cancer Res 14:3319-26. 2008

Research Grants

Detail Information

Publications291 found, 100 shown here

  1. pmc Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Cell Stem Cell 5:54-63. 2009
    ..The results suggest that improvements in animal models and patients after i.v. infusions of MSCs are at least in part explained by activation of MSCs to secrete TSG-6...
  2. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    ..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
  3. pmc Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
    Hosoon Choi
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine at Scott and White, Temple, TX 76502, USA
    Blood 118:330-8. 2011
    ..Because inflammation underlies many pathologic processes, including immune responses, the results may explain the beneficial effects of MSCs and TSG-6 in several disease models...
  4. ncbi Interactions between cancer stem cells and their niche govern metastatic colonization
    Ilaria Malanchi
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research Molecular Oncology, 1015 Lausanne, Switzerland
    Nature 481:85-9. 2012
    ..We suggest that the education of stromal cells by infiltrating tumour cells is an important step in metastatic colonization and that preventing de novo niche formation may be a novel strategy for the treatment of metastatic disease...
  5. ncbi EpCAM in carcinogenesis: the good, the bad or the ugly
    Bernardina T F van der Gun
    Epigenetic Editing, Department of Medical Biology, University Medical Centre Groningen, Hanzeplein 1, Groningen, TheNetherlands
    Carcinogenesis 31:1913-21. 2010
    ..As epigenetic dysregulation underlies aberrant EpCAM expression, we propose epigenetic editing as a novel approach to investigate the biological role of EpCAM, expanding the options for EpCAM as a therapeutic target in cancer...
  6. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
    ..Long-range conformational changes couple these functions via allosteric equilibria...
  7. pmc EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Gastroenterology 136:1012-24. 2009
    ..We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence of hepatic cancer cells with stem/progenitor features...
  8. ncbi Frequent EpCam protein expression in human carcinomas
    Philip Th Went
    Institute for Pathology, University of Basel, Basel, Switzerland
    Hum Pathol 35:122-8. 2004
    ..Most soft-tissue tumors and all lymphomas were EpCam negative. It is concluded that anti-EpCam therapies, if proven to be successful, will have broad applications in a wide variety of carcinomas...
  9. pmc MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer
    Guohong Hu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 15:9-20. 2009
    ..These findings establish MTDH as an important therapeutic target for simultaneously enhancing chemotherapy efficacy and reducing metastasis risk...
  10. ncbi Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival
    Jun Li
    Key Laboratory of Tropical Disease Control Sun Yat sen University, Ministry of Education, Guangzhou, Guangdong, China
    Clin Cancer Res 14:3319-26. 2008
    ....
  11. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
    ..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
  12. ncbi Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 10:1081-8. 2009
    ..Our study reveals another level of plasticity in tailoring adaptive immunity to pathogens...
  13. ncbi The emerging role of EpCAM in cancer and stem cell signaling
    Markus Munz
    Micromet AG, Munich, Germany
    Cancer Res 69:5627-9. 2009
    ..EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway...
  14. ncbi The cadherins: cell-cell adhesion molecules controlling animal morphogenesis
    M Takeichi
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 102:639-55. 1988
    ..Antibodies to cadherins were shown to perturb the morphogenesis of some embryonic organs in vitro. These observations suggest that cadherins play a crucial role in construction of tissues and the whole animal body...
  15. ncbi CEACAMs: their role in physiology and pathophysiology
    Katharina Kuespert
    Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universitat Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany
    Curr Opin Cell Biol 18:565-71. 2006
    Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins...
  16. pmc Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses
    Erika Navarro-Sanchez
    Interactions Moléculaires Flavivirus Hôtes, 25 rue du Dr Roux, 75724 Paris, France
    EMBO Rep 4:723-8. 2003
    ..Mosquito-cell-derived DVs may have differential infectivity for DC-SIGN-expressing cells. We suggest that the differential use of DC-SIGN by viral envelope glycoproteins may account for the immunopathogenesis of DVs...
  17. ncbi Epithelial cell adhesion molecule expression (CD326) in cancer: a short review
    Carlo Patriarca
    Dept of Pathology, Azienda Ospedaliera di Melegnano, Milan, Italy
    Cancer Treat Rev 38:68-75. 2012
    ..Further research and clinical studies should unravel EpCAM's complex role in oncological processes, and expand potential therapeutic applications of EpCAM targeted strategies...
  18. ncbi Cell adhesion molecules: signalling functions at the synapse
    Matthew B Dalva
    University of Pennsylvania Medical Center, Department of Neuroscience, BRB II III, Room 1114, 421 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Neurosci 8:206-20. 2007
    Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide a mechanical link between cells...
  19. ncbi SynCAM, a synaptic adhesion molecule that drives synapse assembly
    Thomas Biederer
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 297:1525-31. 2002
    ....
  20. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002
    ..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...
  21. pmc A core function for p120-catenin in cadherin turnover
    Michael A Davis
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    J Cell Biol 163:525-34. 2003
    ..The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120...
  22. ncbi Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection
    Yi Wei Li
    Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, People s Republic of China
    J Hepatol 54:497-505. 2011
    ..However, its role in hepatocellular carcinoma (HCC) is unclear. In this study, we investigated prognostic values for intratumoral and peritumoral neutrophils in HCC patients undergoing curative resection...
  23. ncbi HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells
    Sonja I Gringhuis
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 11:419-26. 2010
    ..Inhibition of either pathway abrogated replication and prevented HIV-1 transmission. Thus, HIV-1 subverts crucial components of the immune system for replication that might be targeted to prevent infection and dissemination...
  24. pmc Mycobacteria target DC-SIGN to suppress dendritic cell function
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, 1081 BT Amsterdam, Netherlands
    J Exp Med 197:7-17. 2003
    ..Moreover, we demonstrate that DC-SIGN has a broader pathogen recognition profile than previously shown, suggesting that DC-SIGN may represent a molecular target for clinical intervention in infections other than HIV-1...
  25. pmc Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus
    Ryan S Noyce
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS Pathog 7:e1002240. 2011
    ..Several strains of measles virus were also shown to use PVRL4 as a receptor. Measles virus infection reduced PVRL4 surface expression in MCF7 cells, a property that is characteristic of receptor-associated viral infections...
  26. ncbi Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility
    Lindsay Gillan
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Res 62:5358-64. 2002
    ..We propose PN functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins to support adhesion and migration of ovarian epithelial cells...
  27. ncbi Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer
    Bernhard Mlecnik
    INSERM, Integrative Cancer Immunology Team, Inserm U872, Paris, France
    Gastroenterology 138:1429-40. 2010
    ..Herein, we used data integration and biomolecular network reconstruction to generate hypotheses about the mechanisms underlying immune responses in colorectal cancer that are relevant to tumor recurrence...
  28. pmc Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis
    W Ikeda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Osaka 565 0871, Japan
    J Cell Biol 146:1117-32. 1999
    ....
  29. pmc Periostin is essential for cardiac healing after acute myocardial infarction
    Masashi Shimazaki
    Department of Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    J Exp Med 205:295-303. 2008
    ..Our novel findings show the effects of periostin on recruitment of activated fibroblasts through FAK-integrin signaling and on their collagen fibril formation specific to healing after AMI...
  30. pmc Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells
    I Martinez
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Oncogene 27:2575-82. 2008
    ..These findings may contribute to a better understanding of the molecular mechanisms involved in cervical carcinogenesis...
  31. ncbi Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
    Bernhard Kuhn
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Med 13:962-9. 2007
    ..Thus, periostin and the pathway that it regulates may provide a target for innovative strategies to treat heart failure...
  32. pmc DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina
    Peter G Fuerst
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Neuron 64:484-97. 2009
    ..Therefore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic specificity in the mouse retina...
  33. pmc Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells
    Kanyan Xiao
    Department of Dermatology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    J Cell Biol 163:535-45. 2003
    ..These results demonstrate that cellular levels of p120ctn function as a set point mechanism that regulates cadherin expression levels, and that a major function of p120ctn is to control cadherin internalization and degradation...
  34. ncbi The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin
    Yoshimi Takai
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Annu Rev Cell Dev Biol 24:309-42. 2008
    Nectins are immunoglobulin-like cell adhesion molecules (CAMs) that compose a family of four members. Nectins homophilically and heterophilically interact in trans with each other to form cell-cell adhesions...
  35. pmc West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood-brain barrier
    Saguna Verma
    Department of Tropical Medicine, Medical Microbiology and Pharmacology, Asia Pacific Institute of Tropical Medicine and Infectious Diseases, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
    Virology 385:425-33. 2009
    ..kinetics together with the changes in the expressions of key tight junction proteins (TJP) and cell adhesion molecules (CAM)...
  36. ncbi Endothelial cell-cell junctions: happy together
    Elisabetta Dejana
    Department of Biomolecular and Biotechnological Sciences, School of Sciences, Milan University, Italy
    Nat Rev Mol Cell Biol 5:261-70. 2004
  37. ncbi Adhesion molecules and atherosclerosis
    Stefan Blankenberg
    INSERM U525, Faculte de Medecine, 91 Bd de l Hopital, 75634 Paris Cedex 13, France
    Atherosclerosis 170:191-203. 2003
    ..Intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecules (VCAM-1), as well as some of the integrins, induce firm adhesion of inflammatory cells at the vascular ..
  38. pmc Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling
    Xiao Dong Wang
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Neurobiol Dis 42:300-10. 2011
    ..These findings underscore the important role of forebrain CRH-CRHR1 signaling in modulating chronic stress-induced cognitive, structural and molecular adaptations, with implications for stress-related psychiatric disorders...
  39. ncbi Patterned gene expression directs bipolar planar polarity in Drosophila
    Jennifer A Zallen
    Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA
    Dev Cell 6:343-55. 2004
    ..These results indicate that spatial patterns of gene expression coordinate planar polarity across a multicellular population through the localized distribution of proteins required for cell movement...
  40. pmc Periostin promotes chronic allergic inflammation in response to Th2 cytokines
    Miho Masuoka
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Clin Invest 122:2590-600. 2012
    ..Thus, periostin sets up a vicious circle that links Th2-type immune responses to keratinocyte activation and plays a critical role in the amplification and chronicity of allergic skin inflammation...
  41. pmc Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    Toru Oka
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Circ Res 101:313-21. 2007
    ..These are the first genetic data detailing the function of Pn in the adult heart as a regulator of cardiac remodeling and hypertrophy...
  42. pmc Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway
    Rafael Cubas
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cancer 9:253. 2010
    ..Here, we studied the effects murine Trop2 (mTrop2) exerted on tumor cellular functions and some of the signaling mechanisms activated by this oncogene...
  43. ncbi Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta
    K Horiuchi
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    J Bone Miner Res 14:1239-49. 1999
    ..By Western blot analysis, TGF-beta increased periostin expression in primary osteoblast cells. Together, these data suggest that periostin may play a role in the recruitment and attachment of osteoblast precursors in the periosteum...
  44. ncbi Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    Ugo Cavallaro
    Institute of Biochemistry and Genetics, Department of Clincal Biological Sciences, University of Basel Switzerland
    Nat Rev Cancer 4:118-32. 2004
  45. pmc Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
    Takaharu Ichimura
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1657-68. 2008
    ..Thus, KIM-1 is the first nonmyeloid phosphatidylserine receptor identified to our knowledge that transforms epithelial cells into semiprofessional phagocytes...
  46. ncbi Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
    T Ichimura
    Renal Unit, Medical Services, Massachusetts General Hospital East, Boston, Massachusetts 02129, USA
    J Biol Chem 273:4135-42. 1998
    ..KIM-1 may play an important role in the restoration of the morphological integrity and function to postischemic kidney...
  47. pmc Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells
    Anieta M Sieuwerts
    Department of Medical Oncology, Josephine Nefkens Institute, Cancer Genomics Centre, Rotterdam, The Netherlands
    J Natl Cancer Inst 101:61-6. 2009
    ..New tests that include antibodies that specifically recognize normal-like breast tumor cells but not cells of hematopoietic origin are needed...
  48. ncbi Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity
    N Kikuno
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Oncogene 26:7647-55. 2007
    ..AEG-1 may therefore represent a novel genetic biomarker to serve as an attractive molecular target for new anticancer agents to prevent PC cell progression and metastasis...
  49. pmc West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection
    Carl W Davis
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Virol 80:1290-301. 2006
    ..We believe this is the first report of a pathogen interacting more efficiently with DC-SIGNR than with DC-SIGN. Our results should lead to the discovery of new mechanisms by which these well-studied lectins discriminate among ligands...
  50. ncbi C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunity 26:605-16. 2007
    ..Thus, this pathway is involved in regulation of adaptive immunity by DCs to bacterial, fungal, and viral pathogens...
  51. pmc Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers
    P Went
    Institute of Pathology, University Hospital Basel, Schonbeinstrasse 40, 4003 Basel, Switzerland
    Br J Cancer 94:128-35. 2006
    ....
  52. ncbi Circulating cell adhesion molecules and death in patients with coronary artery disease
    S Blankenberg
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Circulation 104:1336-42. 2001
    ..In a model that simultaneously controlled for all inflammatory and soluble adhesion markers determined, only sVCAM-1 remained independently significant for future fatal cardiovascular events, with a 2.8-fold increase in risk (P=0.003)...
  53. pmc Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
    Benjamin L Allen
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, 48109, USA
    Dev Cell 20:775-87. 2011
    ..Most strikingly, genetic loss-of-function experiments indicate an obligatory requirement for GAS1, CDO, and BOC in HH pathway activity in multiple tissues...
  54. pmc Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration
    I Martin-Padura
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Cell Biol 142:117-27. 1998
    ..Thus, JAM is a new component of endothelial and epithelial junctions that play a role in regulating monocyte transmigration...
  55. pmc Roles for microRNAs in the regulation of cell adhesion molecules
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Sci 124:999-1006. 2011
    ..This, in turn, holds important implications for our understanding of both the basic biology of cell adhesion and the etiology of multiple pathological conditions...
  56. ncbi TSG-6 modulates the interaction between hyaluronan and cell surface CD44
    Jayne Lesley
    Molecular and Cell Biology Laboratory, The Salk Institute, San Diego, California 92186, USA
    J Biol Chem 279:25745-54. 2004
    ..The ability of TSG-6 to modulate the interaction of hyaluronan with CD44 has important implications for CD44-mediated cell activity at sites of inflammation, where TSG-6 is expressed...
  57. pmc A novel role for p120 catenin in E-cadherin function
    Renee C Ireton
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 159:465-76. 2002
    ..These data reveal a cooperative interaction between p120 and E-cadherin and a novel role for p120 that is likely indispensable in normal cells...
  58. ncbi Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells
    Tomohiko Wakayama
    Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Biol Reprod 76:1081-90. 2007
    ..These findings suggest that the heterophilic binding of PVR to IGSF4A is responsible, at least in part, for the interaction between Sertoli and spermatogenic cells during mouse spermatogenesis...
  59. pmc Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells
    M C Ryan
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biol 145:1309-23. 1999
    ..These results indicate that laminin 5 has an important role in regulating tissue organization, gene expression, and survival of epithelium...
  60. ncbi Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
    R J Geraghty
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 280:1618-20. 1998
    ..HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system...
  61. pmc In vivo regulation of Yorkie phosphorylation and localization
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:1081-8. 2008
    ..These results identify modulation of subcellular localization as a mechanism of Yki regulation, and establish that this regulation occurs in vivo through multiple sites of Warts-dependent phosphorylation on Yki...
  62. ncbi TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer
    M Kuramochi
    Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Nat Genet 27:427-30. 2001
    ..2. Thus, attenuation of TSLC1 expression occurred in 85% of primary tumors with LOH. Hypermethylation of the TSLC1 promoter would seem to represent the 'second hit' in NSCLC with LOH...
  63. ncbi Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes
    Ian C Boulton
    Department of Medical Genetics and Microbiology, University of Toronto, Medical Sciences Building Rm 4381, 1 Kings College Circle, Toronto, Ontario M5S1A8, Canada
    Nat Immunol 3:229-36. 2002
    ..CEACAM1 bound by gonococcal Opa52 associated with the tyrosine phosphatases SHP-1 and SHP-2, which implicates the receptor's ITIM (immunoreceptor tyrosine-based inhibitory motif) in this effect...
  64. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
    ..Thus, while our results support the existence of Ft-Ds binding and show that it is sufficient to alter PCP, ds expression is permissive or redundant with other PCP cues in much of the wing...
  65. pmc Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors
    Gyu Un Bae
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Hum Genet 89:231-40. 2011
    ..Our findings argue that CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and that disruption of the latter interactions is a mechanism of HPE...
  66. ncbi Par-3 controls tight junction assembly through the Rac exchange factor Tiam1
    Xinyu Chen
    Center for Cell Signaling, Department of Microbiology, HSC, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Cell Biol 7:262-9. 2005
    ..These results define a critical function for Par-3 in tight junction assembly, and reveal a novel mechanism through which Par-3 engages in the spatial regulation of Rac activity and establishment of epithelial polarity...
  67. ncbi The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:532-8. 2003
    ..albicans receptor expressed by DC. Together, these results demonstrate that DC-SIGN is an exquisite pathogen-uptake receptor that captures not only viruses but also fungi...
  68. ncbi UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
    S S Chan
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Cell 87:187-95. 1996
    ..Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells...
  69. ncbi CEACAM1: contact-dependent control of immunity
    Scott D Gray-Owen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Nat Rev Immunol 6:433-46. 2006
    ..In this Review, we consider the evidence for CEACAM involvement in immunity, with a particular emphasis on CEACAM1, which functions as a regulatory co-receptor for both lymphoid and myeloid cell types...
  70. ncbi Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer
    Bo Zhang
    Department of Pathophysiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China
    Carcinogenesis 32:2-9. 2011
    ..Our findings suggest that miR-26a functionally antagonizes human breast carcinogenesis by targeting MTDH and EZH2...
  71. ncbi C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity
    Urban Svajger
    Blood Transfusion Center of Slovenia, Slajmerjeva 6, 1000 Ljubljana, Slovenia
    Cell Signal 22:1397-405. 2010
    ..In this article, we will discuss recent advances on a broad perspective concerning DC-SIGN structure, signalling and immune function...
  72. ncbi Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation
    Yoshimi Takai
    Department of Biochemistry and Molecular Biology, Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    Nat Rev Mol Cell Biol 9:603-15. 2008
    Nectins and nectin-like molecules (Necls) are immunoglobulin-like transmembrane cell adhesion molecules that are expressed in various cell types...
  73. pmc The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
    Abigail Woodfin
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Nat Immunol 12:761-9. 2011
    ..Our results identify JAM-C as a key regulator of polarized neutrophil TEM in vivo and suggest that reverse TEM of neutrophils can contribute to the dissemination of systemic inflammation...
  74. ncbi Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    F B Gertler
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:227-39. 1996
    ..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
  75. pmc An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration
    G D Turner
    Molecular Parasitology Group, John Radcliffe Hospital, Oxford, UK
    Am J Pathol 145:1057-69. 1994
    ..These results suggest that these receptors have a role in sequestration in vivo and indicate that systemic endothelial activation is a feature of fatal malaria...
  76. pmc Complementary adhesin function in C. albicans biofilm formation
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York 10032, USA
    Curr Biol 18:1017-24. 2008
    ..Here, we focus on an adherence mechanism that permits biofilm formation by Candida albicans, the major invasive fungal pathogen of humans...
  77. ncbi Cell adhesion molecules: role and clinical significance in cancer
    Nektaria Makrilia
    Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Greece
    Cancer Invest 27:1023-37. 2009
    ..Indeed, changes in the expression or function of cell adhesion molecules have been implicated in all steps of tumor progression, including detachment of tumor cells from the ..
  78. ncbi Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway
    Shideng Bao
    The Key Laboratory for Cell Biology and Tumor Cell Engineering, The Ministry of Education of China, The School of Life Sciences, Xiamen University, Fujian 361005, China
    Cancer Cell 5:329-39. 2004
    ..These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer...
  79. pmc Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines
    Agnieszka Martowicz
    Laboratory of Experimental Oncology, Tyrolean Cancer Research Institute, Innsbruck, Austria
    BMC Cancer 12:501. 2012
    ..This study analyzes the effects of EpCAM on breast cancer cell lines with epithelial or mesenchymal phenotype...
  80. ncbi Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response
    William A Muller
    Department of Pathology, and Laboratory Medicine, Graduate Program in Immunology, Weill Medical College, 1300 York Avenue, New York, NY 10021, USA
    Trends Immunol 24:327-34. 2003
    ..These leukocyte-endothelial-cell adhesion molecules are probably involved in regulating the signaling as well as the adhesion events of diapedesis...
  81. ncbi Receptors that interact with nectin and nectin-like proteins in the immunosurveillance and immunotherapy of cancer
    Christopher J Chan
    Cellular Immunity Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne 3002, Australia
    Curr Opin Immunol 24:246-51. 2012
    ..This review will outline the immunobiology of these receptors, the contexts where their function is important, their role in tumour immunosurveillance, and how they may be utilised for therapeutic applications in cancer...
  82. ncbi Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals
    Pierre Yves Lozach
    Unite d Immunologie Virale, Institut Pasteur Paris, 25 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:23698-708. 2005
    ....
  83. pmc Activator protein 1 (AP-1) contributes to EpCAM-dependent breast cancer invasion
    Narendra V Sankpal
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St, Louis, Missouri 63110, USA
    Breast Cancer Res 13:R124. 2011
    ..However, the functional role of EpCAM in regulating cancer invasion remains controversial, and the mechanism(s) underlying EpCAM-mediated regulation of breast cancer invasion remain to be defined...
  84. pmc CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis
    Hui Liu
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:1379-84. 2011
    ..In addition, the Y734F mutation also eliminated enhanced Src activation. Thus, this work provides molecular mechanisms for the metastasis-enhancing functions of CDCP1...
  85. ncbi Mutations in the gene encoding CADM1 are associated with autism spectrum disorder
    Yu Zhiling
    Department of Pediatrics, Jichi Medical University, 3311 1 Yakushiji, Shimotsukeshi, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 377:926-9. 2008
    ..Our findings provide key support for the unified idea that impaired synaptogenesis underlies the pathogenesis of ASD...
  86. ncbi Impairment of social and emotional behaviors in Cadm1-knockout mice
    Yuki Takayanagi
    Department of Physiology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    Biochem Biophys Res Commun 396:703-8. 2010
    ....
  87. ncbi SynCAMs organize synapses through heterophilic adhesion
    Adam I Fogel
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 27:12516-30. 2007
    ..They function as cell adhesion molecules and assemble with each other across the synaptic cleft into a specific, transsynaptic SynCAM 1/2 complex...
  88. ncbi Function and histopathology of a cell adhesion molecule TSLC1 in cancer
    Qi lian Liang
    Department of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China
    Cancer Invest 29:107-12. 2011
    ..On the basis of these, we propose that TSLC1 represents a promising biomarker for cancer diagnosis and a potential target for cancer therapy...
  89. ncbi EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:1451-61. 2008
    ....
  90. pmc Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission
    Li Wu
    HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Virol 76:5905-14. 2002
    ..While these findings do not discount the role of intercellular contact in facilitating HIV-1 transmission, our in vitro data indicate that DC-SIGN interactions with ICAM-3 do not promote DC-SIGN-mediated virus transmission...
  91. pmc STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Jen Liou
    Department of Molecular Pharmacology, Stanford University Medical School, California 94305, USA
    Curr Biol 15:1235-41. 2005
    ..Our study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(2+) store depletion to Ca(2+) influx...
  92. pmc Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner
    Vasanthi Avadhanula
    Department of Infectious Diseases, St Jude Children s Research Hospital, Mailstop 320, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Virol 80:1629-36. 2006
    ..These studies highlight the distinct responses of different cell types to viral infection and the need to consider this variation when interpreting studies of the interactions between respiratory cells and viral pathogens...
  93. ncbi The multifaceted role of periostin in tumorigenesis
    Kai Ruan
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, China
    Cell Mol Life Sci 66:2219-30. 2009
    ..In this review, aspects related to the function of periostin in tumorigenesis are summarized...
  94. pmc Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 604 Parran Hall, 130 De Soto St, Pittsburgh, PA 15261, USA
    J Virol 82:4793-806. 2008
    ..Thus, the expression of DC-SIGN is essential for productive HHV-8 infection of and replication in B cells...
  95. ncbi Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes
    J Fawcett
    ICRF Laboratories, University of Oxford, UK
    Nature 360:481-4. 1992
    ..ICAM-3 is closely related to ICAM-1, consists of five immunoglobulin domains, and binds LFA-1 through its two N-terminal domains...
  96. pmc Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6
    Virginia Maina
    Research Laboratory in Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    J Leukoc Biol 86:123-32. 2009
    ..The coordinated expression of PTX3 and TSG-6 may play a role in ECM remodeling at sites of inflammation...
  97. pmc Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells
    Tung Ying Lu
    Institute of Cellular and Organismic Biology, Consiglio Nazionale delle Ricerche, Milan 20131, Italy
    J Biol Chem 285:8719-32. 2010
    ..The expression of EpCAM may be regulated by epigenetic mechanisms, and it is strongly associated with the maintenance of the undifferentiated state of hESCs...
  98. ncbi Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:575-85. 2000
    ..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
  99. ncbi Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
    Go Takayama
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Allergy Clin Immunol 118:98-104. 2006
    ..We have previously identified the POSTN gene encoding periostin as an IL-4/IL-13-inducible gene in bronchial epithelial cells. Periostin is thought to be an adhesion molecule because it possesses 4 fasciclin I domains...
  100. ncbi Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice
    E Georges-Labouesse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, C U de Strasbourg, France
    Nat Genet 13:370-3. 1996
    ..Our study provides evidence that some forms of epidermolysis bullosa may originate from defects of the alpha 6 gene...
  101. ncbi VAP-1: an adhesin and an enzyme
    M Salmi
    MediCity Research Laboratory, Tykistokatu 6A, University of Turku, FIN 20520 Turku, Finland
    Trends Immunol 22:211-6. 2001
    ..Thus, VAP-1 is an ectoenzyme that has inter-related adhesive and enzymatic functions in regulating physiological trafficking and inflammation...

Research Grants71

  1. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..A novel family of cell adhesion molecules (CAMs), the Synaptic Cell Adhesion Molecules (SynCAMs), has recently been proposed to mediate the ..
  2. Tumor Cell Arrest and Adhesion in the Microcirculation
    Bingmei M Fu; Fiscal Year: 2013
    ..between microcirculation-induced mechanical factors, microvascular permeability (vascular integrity), cell adhesion molecules, nitric oxide and cytokines, and tumor metastasis in intact microvessels...
  3. The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide Receptors
    GARY ANDREW WEISMAN; Fiscal Year: 2013
    ..integrin/extracellular matrix interactions, cytoskeletal rearrangements and the expression of cell adhesion molecules and tight junction proteins...
  4. Analyzing Anthrax Toxins in Drosophilia
    Ethan Bier; Fiscal Year: 2013
    ..By inhibiting endocytic recycling, anthrax toxins also reduce levels of cell adhesion molecules (e.g., cadherins) and signaling proteins (e.g...
  5. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..late stage" plaque which is more likely to rupture, whereas certain proteins on the vessel wall, the cell adhesion molecules, may signal "early warning signs" to start treatment to curb risks...
  6. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..linker between transmembrane integrin receptors and the actin cytoskeleton through association with cell adhesion molecules. Release of autoinhibitory head/tail interactions is believed to activate vinculin's function as a ..
  7. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    ..are secreted (such as immunoglobulins and polypeptide hormones) or present at the cell surface (including cell adhesion molecules and signaling receptors) are produced and folded by the endoplasmic reticulum (ER)...
  8. Distinct roles of CARP target genes in wound healing
    Karinna Almodóvar; Fiscal Year: 2013
    ..is that CARP protein regulates the transcription of genes coding for matrix-degrading proteases, cell adhesion molecules, and other genes associated with the process of ECM remodeling and capillary morphogenesis during the ..
  9. Chronic stress-induced gene expression in colonic circular smooth muscle cells.
    Sushil K Sarna; Fiscal Year: 2012
    ..The inflammatory response is mediated by cytokines, chemokines and cell adhesion molecules. However, under conditions of chronic stress or uncontrolled inflammation, these adaptive systems become ..
  10. Analysis of alphaVbeta8 Integrin In Gliomagenesis
    Joseph H McCarty; Fiscal Year: 2012
    ..In this project we will study how cell adhesion molecules, known as integrins, regulate the onset and progression of gliomas in mice and humans...
  11. Dose Ranging study of the Effects of Alpha Acid on Oxidative Stress
    Pamela Ouyang; Fiscal Year: 2010
    ..Lipoic acid also suppresses the endothelial cell NF-kappaB activation and the expression of cell adhesion molecules by advanced glycation end-products...
  12. Regulation of colitis by orphan nuclear receptor Nur77
    Dezheng Zhao; Fiscal Year: 2013
    ..Activated IMEC secrete various pro- inflammatory mediators and express cell-cell adhesion molecules that facilitate leukocyte infiltration...
  13. Obesity, vascular inflammation, and immune cell activation in prehypertension
    Suzi Hong; Fiscal Year: 2013
    ..inflammation and immune cell activation by assessing levels of: endothelin-1, soluble endothelial cell adhesion molecules (CAM), plasma inflammatory cytokines, CAM expression on immune cells, cytokine producing cells upon ..
  14. Axon Guidance in the Olfactory System
    DIEGO JAVIER RODRIGUEZ-GIL; Fiscal Year: 2013
    ..Axon guidance cues, cell adhesion molecules, and odor receptor induced activity have all been implicated in the precise final targeting of OSN axons ..
  15. Development of an Anti-PSGL-1 Antibody to Treat Crohn's Disease
    Scott A Rollins; Fiscal Year: 2011
    ..the first step in the recruitment of leukocytes to sites of inflammation by binding to selectins, cell adhesion molecules that are upregulated in Crohn's Disease patients...
  16. Steroid-Dependent Changes in the Yorkie Interactome
    Alexey Veraksa; Fiscal Year: 2013
    ..Yki/Yap1 is to serve as a key target of contact- inhibition mechanisms through which membrane-associated cell adhesion molecules 'sense'cell crowding and inhibit Yki/Yap1 to keep cells in a post-mitotic state...
  17. Biomimetic scaffolds for targeted peripheral nerve regeneration
    DAVID SHREIBER; Fiscal Year: 2009
    ..We have developed peptide mimics of two carbohydrates carried by neural cell adhesion molecules that are important in targeted innervation during development and that promote neuron survival and ..
  18. Role of axoglial CAMs in the organization of myelinated axons
    Elior Peles; Fiscal Year: 2013
    ..We have previously identified several cell adhesion molecules (CAMs), including gliomedin, Caspr, Caspr2, and Necl4, which mediate axoglial contact at specific sites ..
  19. Nano-sized Cell Guidance System for Ischemic Tissue Repair
    Hyunjoon Kong; Fiscal Year: 2010
    ..poly(glycerol) linked with both epitopes binding with transplanted cells and those binding with vascular cell adhesion molecules (VCAM)-1 will precisely guide transplanted cells to the injured endothelium because the endothelial ..
  20. MMPs, Integrins and Microglial activation in HAND
    KATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013
    ..that are widely expressed in the CNS, including the immunoglobulin (Ig) domain containing intercellular cell adhesion molecules (ICAMs) and synaptic CAMs (synCAMs), as well as the cadherins...
  21. Modulation of liver cancer by PPARbeta/delta
    Jeffrey M Peters; Fiscal Year: 2013
    ..has epigenetic activities that include inhibiting expression of proinflammatory cytokines, chemokines and cell adhesion molecules via interacting with other transcription factors...
  22. Pathogenesis of TSC2-Related Tumors
    Raymond Yeung; Fiscal Year: 2012
    ..We hypothesize that mTOR can affect plasma membrane targeting of hexose transporters such as Glut4 and cell adhesion molecules such as E-cadherin resulting in modulation of glucose uptake and cell-cell adhesion, respectively...
  23. ISOLATION AND CHARACTERIZATION OF SYNAPTOGENIC PROTEINS
    JUAN L BRUSES; Fiscal Year: 2011
    ..is needed to trigger synapse formation, and 3) to test whether cell surface expression of GPI- linked cell adhesion molecules regulates the surface expression levels of nicotinic acetylcholine neurotransmitter receptors...
  24. Rho-mediated Signaling in Lung Endothelial Cells Induced by Neutrophil Adhesion
    KLAUS MICHAEL HAHN; Fiscal Year: 2013
    ..For this to occur, neutrophils must first adhere to cell adhesion molecules (particularly E-selectin and ICAM-1) expressed on the surface of endothelial cells lining blood vessels...
  25. Nitric oxide protects against microcirculatory complications of malaria
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2010
    ..parasitized erythrocytes (pRBCs), platelets, and leukocytes occur during ECM and deficiency of selected cell adhesion molecules protects against malaria pathogenesis...
  26. Structural Analysis of Reovirus Attachment Mechanisms
    Thilo Stehle; Fiscal Year: 2013
    ..These studies will enhance a basic understanding of mechanisms by which pathogenic viruses engage cellular receptors and accelerate the rational design of viral vectors for therapeutic purposes. ..
  27. High-throughput Pipeline for Electron Crystallography
    David L Stokes; Fiscal Year: 2013
    ..context, membrane proteins act as receptors, enzymes, channels, transporters, structural proteins and cell adhesion molecules and, as such, contribute to a wide variety of essential cellular functions...
  28. GABAA Receptor-Interacting Proteins
    Angel L De Blas; Fiscal Year: 2013
    ..and gephyrin in regulating postsynaptic GABAA receptor clustering;2) to study the role of protocadherin cell adhesion molecules in GABAergic synapses and 3) to study the role that a newly identified GABAA receptor-interacting protein ..
  29. Regulation of call adhesion in Xenopus
    KEN CHO; Fiscal Year: 2009
    ..b>Cell adhesion molecules such as cadherins, protocadherins and integrins have been implicated in the differential regulation of ..
  30. Use or Metabolomic Markers of Response to Fish Oil Supplementation to Identify Ef
    CHARLES BOLT STEPHENSEN; Fiscal Year: 2011
    ..protein markers of inflammation to be measured for this study, including cytokines, chemokines, soluble cell adhesion molecules, acute phase proteins, proteases and anti-proteases, and complement components...
  31. PTP mu Supresses Brain Tumor Cell Migration and Dispersal
    Susann M Brady Kalnay; Fiscal Year: 2010
    ..b>Cell adhesion molecules are important regulators of adhesion-dependent signals such as contact inhibition of growth and movement...
  32. Role of Ed in regulating EGFR and Notch signaling during retinal development
    Susan A Spencer; Fiscal Year: 2010
    ..Ed is thought to be a functional homolog of the nectins, a family of vertebrate cell adhesion molecules that regulate a variety of developmental processes...
  33. Function of Desmoglein 1/Pemphigus Foliaceus Antigen
    KATHLEEN JANEE GREEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The desmosomal cadherins are cell-cell adhesion molecules that are essential for epidermal integrity...
  34. The Role of Afadin in Coordinating Cell Adhesion Molecules during Synaptogenesis
    GERARD MJ BEAUDOIN; Fiscal Year: 2010
    ..This proposal is studying the associations between different classes of adhesion proteins and the role of this association in creating and modifying synapses, which is likely to play a role in generating synaptic specificity. ..
  35. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2012
    ..In adherens junctions, the catenins link transmembrane cadherin cell adhesion molecules to the actin-based cytoskeleton, and in desmosomes an analogous protein assembly links cadherins to ..
  36. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2012
    ..The complex protein interactions mediated by immunoglobulin-like cell adhesion molecules (IgCAMs), which can form cell-cell and cell-extracellular matrix (ECM) interactions, have complicated ..
  37. Tissue Factor splicing and pancreatic tumor progression: pilot studies
    VLADIMIR BOGDANOV; Fiscal Year: 2013
    ..is abundant in PDAC lesions, but not normal ducts, and promotes monocyte recruitment via upregulation of cell adhesion molecules on endothelial cells...
  38. Stimulus-Secretion Coupling in Diseased Lacrimal Gland
    Driss Zoukhri; Fiscal Year: 2013
    ..hypotheses, we propose the following specific aims: 1-Iinvestigate changes in the extracellular matrix, cell adhesion molecules and matrix modifying enzymes in chronically inflamed lacrimal glands;2-Test the hypothesis that ..
  39. Presenilins and Cell Adhesion Molecules
    Angele Parent; Fiscal Year: 2012
    ..In addition to intramembranous cleavage of APP, Notch ligands/Notch receptor, and several cell adhesion molecules (CAMs) including cadherins, protocadherins, DCC, ErbB4, ephrin/Eph receptors, nectin-1alpha and syndecan, ..
  40. High-Resolution 3D Ultrasound Imaging &Quantification of Murine Cardiac Function
    John A Hossack; Fiscal Year: 2012
    ..Additionally, we plan to map the presence of specific cell adhesion molecules (i.e., PECAM and selectin) that are presented on the endothelial surface following an ischemic event...
  41. Molecular Imaging of Inflammation in Atherosclerosis
    Jonathan R Lindner; Fiscal Year: 2012
    ..could be assessed with contrast-enhanced ultrasound and contrast agents targeted to endothelial cell adhesion molecules (ECAMs)...
  42. Mechanisms of Transmigration of HIV Infected Cells Across the Blood Brain Barrier
    TONI KAY ROBERTS; Fiscal Year: 2010
    ..We hypothesize that HIV infection of monocytes alters their expression of CCR2, cell adhesion molecules, and adherens and tight junction proteins, and that transmigration of these infected monocytes in ..
  43. Molecular and Force Dynamics: Leukocyte Adhesion Molecules
    SCOTT IRWIN SIMON; Fiscal Year: 2013
    ..process initiated by membrane expression and functional activation of leukocyte and endothelial cell adhesion molecules (CAMs) including selectins, integrins, and Ig-super family ligands...
  44. Transcontinental EM Initiative for Membrane Protein Structure
    David L Stokes; Fiscal Year: 2013
    ..context, membrane proteins act as receptors, enzymes, channels, transporters, structural proteins and cell adhesion molecules and, as such, contribute to a wide variety of essential cellular functions...
  45. Neuroligin Regulation of Central GABAergic Synapses
    Zhanyan Fu; Fiscal Year: 2010
    ..NLs are postsynaptic cell adhesion molecules (CAMs) expressed on the surface of postsynaptic membrane...
  46. Novel Mechanisms of Chronic Inflammation in Sjogren's Syndrome
    GARY ANDREW WEISMAN; Fiscal Year: 2010
    ..of salivary glands in SS is mediated by P2Y2R signaling pathways leading to the up-regulation of cell adhesion molecules that promote the binding of lymphocytes, a novel pathway that can be exploited to retard the development ..
  47. Cell Adhesion Molecules in CNS Development
    Ulrich Mueller; Fiscal Year: 2013
    ..We anticipate that knowledge of how these receptors control migration will be relevant for understanding the mechanisms leading to pathological changes associated with several neurological disorders. ..
  48. Vaccine-Dac/Bev Combinatorial Therapy in Ovarian Cancer
    George Coukos; Fiscal Year: 2012
    ..blood-tumor barrier preventing extravasation of effector T cells into tumors (through down-regulation of cell adhesion molecules), or killing extravasating T cells in tumors (through FasL-mediated apoptosis);b) Treg cells located in ..
  49. Targeting Pathways of Axonal Cell Adhesion Molecules
    BETTINA R WINCKLER; Fiscal Year: 2012
    ..Since L1 expression is upregulated after neuronal injury and after stroke, understanding L1 trafficking to axons has implications for regenerative processes after injury. ..
  50. Disrupting FSGS1-associated Actin Assembly in Glomerulosclerosis
    Vivian Tang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Interaction of cell-cell adhesion molecules with the actin cytoskeleton is critical for the maintenance and stability of the glomerular filtration barrir formed by the slit diaphragm...
  51. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2013
    ..In previous work, we have found that osteoblasts express members of the cadherin superfamily of cell adhesion molecules, in particular cadherin-11 (Cad11) and N-cadherin (Ncad)...
  52. Mechanisms of highly efficient HIV transfer at virological synapses
    Benjamin Chen; Fiscal Year: 2012
    ..structures that are driven by Env engagement, cell signaling, actin rearrangements and recruitment of cell adhesion molecules. Despite anecdotal evidence supporting this mode of viral spread, studies have yet to rigorously examine ..
  53. Mechanisms of Node of Ranvier Assembly
    James Salzer; Fiscal Year: 2013
    ..a multimeric complex that includes voltage gated sodium and potassium channels, accessory beta subunits, cell adhesion molecules (CAMs), and a cytoskeletal complex that includes ankyrin G to which channels and CAMs bind...
  54. NF-kB Signaling in Osteoclastogenesis and Osteolytic Bone Metastasis
    Cun Yu Wang; Fiscal Year: 2013
    ..which regulates a broad range of gene expression, including pro-inflammatory cytokines, chemokines and cell adhesion molecules. Using in vitro and in vivo model systems, we have found that constitutive NF-[unreadable]B activities in ..
  55. ABCG1 and endothelial function
    ALAN RICHARD TALL; Fiscal Year: 2013
    ..lesions involving decreased bioavailability of eNOS-derived NO and increased expression of cell adhesion molecules and inflammatory chemokines and cytokines...
  56. Cell adhesion molecules in autism: a whole-brain study of genetic mouse models
    Pavel Osten; Fiscal Year: 2013
    ..The current project is focused on three mouse models carrying mutations in cell adhesion molecules (CAMs): the neuroligin 3 R451C, neuroligin 4 null, and Cntnap2 null mice...
  57. Dynamics of Rac1 GTPase Activity at De Novo Cell-Cell Adhesions
    KHAMEEKA NICOLE KITT; Fiscal Year: 2012
    ..Upon two cells coming together, the actin cytoskeleton becomes reorganized to allow for cell adhesion molecules (cadherins) to engage with similar molecules on an opposing contacting membrane...
  58. Concerted role for integrin alpha3beta1 and TGFb signaling in cancer progression
    Sita Subbaram; Fiscal Year: 2013
    ..Integrins are important cell adhesion molecules that mediate extracellular matrix adhesion, contribute to cellular signaling and promote cell migration...
  59. p120-catenin sub-family functions
    Pierre D McCrea; Fiscal Year: 2010
    ..For example, in addition to binding the inner (cytoplasmic) domain of cadherin trans-membrane cell-cell adhesion molecules, beta-catenin is well known to play an essential role in Wnt developmental signaling where within the ..
  60. The role of BARHL2 in the mosaic pattering and dendritic tiling of retinal amacri
    Lin Gan; Fiscal Year: 2013
    ..cell bodies and in the dendritic arborization, which begins to implicate the roles of unique classes of cell adhesion molecules (CAMs) in regulating these processes in the vertebrate retina...
  61. Mechanosensor Development, Function and Dysfunction
    Ulrich Mueller; Fiscal Year: 2012
    ..We propose here to study the function of the cell adhesion molecules cadherin 23 (CDH23) and protocadherin 15 (PCDH15) in hair cell function and disease...
  62. Creating a 3D dynamic in vitro model of the tumor microenvironment to characteriz
    LUIS FERNANDO ALONZO; Fiscal Year: 2013
    ..is TAM-derived tumor necrosis factor-alpha (TNF-), which is believed to cause the downregulation of cell adhesion molecules (e.g. E-cadherin) in tumor cells, increasing cell motility and entry into the circulation...
  63. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..their dissimilar structures, both proteoglycans bind specifically and with high affinity to neural cell adhesion molecules and the extracellular matrix protein tenascin...
  64. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..proteins implicated in acute phase and inflammatory responses including certain cytokines and chemokines, cell adhesion molecules and inflammatory enzymes; several of these molecules are involved in the pathogenesis of atherosclerosis...
  65. Mucus Penetrating Nanoparticles for Vaginal Drug Delivery
    Justin Hanes; Fiscal Year: 2009
    ..If successful, this project could lead to the development of sustained drug delivery systems that are more convenient, and more effective, for preventing and treating diseases than methods now available. ..
  66. Migration of polyomavirus JC across the blood-brain-barrier
    Vivek Nerurkar; Fiscal Year: 2009
    ..brain microvascular endothelial (HBMVE) cells or if JCV-infected B cells alter the expression patterns of cell adhesion molecules (CAM), such as very late antigen-4 (VLA-4) and lymphocyte function associated-antigen-1 (LFA-1), and ..
  67. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2005
    ..falciparum have activated endothelium with increased expression on endothelium of a number of cell adhesion molecules (CAMs)...
  68. Oligodendrocyte Differentiation and Myelin Biogenesis
    Rashmi Bansal; Fiscal Year: 2007
    ..The proposed participation in this regulation of cell adhesion molecules, src-family kinases, and FGF receptor-3 will be investigated. AIM II...
  69. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..Cell contact-dependent communication is often mediated by cell adhesion molecules which often get clustered into macromolecular assemblies called cell junctions...
  70. Stage-Specific Germ Cell-Sertoli Cell Interactions
    William Wright; Fiscal Year: 2007
    ..Sertoli cells express genes encoding cell adhesion molecules, growth factors, transport proteins, proteases and protease inhibitors required by male germ cells...
  71. Glycoside Inhibitors of Tumor Metastasis
    Jeffrey Esko; Fiscal Year: 2009
    ..sLe x) on cell surface glycoconjugates, sLe x constitutes part of the carbohydrate ligand recognized by cell adhesion molecules belonging to the family of selectin receptors on platelets, leukocytes, and endothelial cells, sLe x-..