surface antigens

Summary

Summary: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.

Top Publications

  1. ncbi Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3260-5. 2006
  2. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
  3. ncbi Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Science 304:1147-50. 2004
  4. ncbi Identification of a factor that links apoptotic cells to phagocytes
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Nature 417:182-7. 2002
  5. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
  6. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
  7. ncbi Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    H Nishimura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:141-51. 1999
  8. pmc MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    R Shimazu
    Department of Immunology, Saga Medical School, Saga, Japan
    J Exp Med 189:1777-82. 1999
  9. doi Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
  10. pmc Phosphorylation of HuR by Chk2 regulates SIRT1 expression
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 25:543-57. 2007

Research Grants

Detail Information

Publications315 found, 100 shown here

  1. ncbi Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3260-5. 2006
    ..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC...
  2. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
    ..These studies identify a specific mechanism of T-cell exhaustion and define a potentially effective immunological strategy for the treatment of chronic viral infections...
  3. ncbi Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Science 304:1147-50. 2004
    ..These data demonstrate that MFG-E8 has a critical role in removing apoptotic B cells in the germinal centers and that its failure can lead to autoimmune diseases...
  4. ncbi Identification of a factor that links apoptotic cells to phagocytes
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Nature 417:182-7. 2002
    ..These results indicate that MFG-E8 secreted from activated macrophages binds to apoptotic cells, and brings them to phagocytes for engulfment...
  5. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
    ..PD-L1 expression on nonlymphoid tissues and its potential interaction with PD-1 may subsequently determine the extent of immune responses at sites of inflammation...
  6. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
  7. ncbi Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    H Nishimura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:141-51. 1999
    ..Collectively, it is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses...
  8. pmc MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    R Shimazu
    Department of Immunology, Saga Medical School, Saga, Japan
    J Exp Med 189:1777-82. 1999
    ..MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms...
  9. doi Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
    ..In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity...
  10. pmc Phosphorylation of HuR by Chk2 regulates SIRT1 expression
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 25:543-57. 2007
    ..Our findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes...
  11. ncbi Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    H Nishimura
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo, Kyoto, 606 8501, Japan
    Science 291:319-22. 2001
    ..These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases...
  12. pmc B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    S Y Tseng
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Exp Med 193:839-46. 2001
    ..These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses...
  13. ncbi Characterization of human blood dendritic cell subsets
    Kelli P A MacDonald
    Dendritic Cell Laboratory, Mater Medical Research Institute, Mater Misericordiae Hospitals, South Brisbane, Australia
    Blood 100:4512-20. 2002
    ..These data provide an opportunity to standardize the DC populations used for future molecular, functional and possibly even therapeutic studies...
  14. pmc Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    Yoshiko Iwai
    Department of Medical Chemistry, Graduate School of Medicine, Japan Science and Technology Corporation, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 99:12293-7. 2002
    ....
  15. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  16. pmc Surface antigens of human embryonic stem cells: changes upon differentiation in culture
    Jonathan S Draper
    Department of Biomedical Science, University of Sheffield, UK
    J Anat 200:249-58. 2002
    ..The surface antigens characteristically expressed by hES cells were down-regulated following induction of differentiation and ..
  17. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...
  18. pmc RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
    Stefanie Galban
    LCMB, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Mol Cell Biol 28:93-107. 2008
    ..Conversely, HIF-1alpha expression and translation in response to CoCl(2) were markedly elevated after HuR overexpression. We propose that HuR and PTB jointly upregulate HIF-1alpha translation in response to CoCl(2)...
  19. ncbi PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2
    LauraL Carter
    Wyeth Genetics Institute, Cambridge, MA 02140, USA
    Eur J Immunol 32:634-43. 2002
    ..However, CD8(+) T cells may be more sensitive to modulation by the PD-1:PD-L pathway because of their intrinsic inability to produce significant levels of IL-2...
  20. ncbi Expression of programmed death 1 ligands by murine T cells and APC
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:5538-45. 2002
    ..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
  21. ncbi Prognostic role of HuR in hereditary breast cancer
    Mira Heinonen
    Department of Pathology HUSLAB and Haartman Institute, Helsinki University Central Hospital, Finland
    Clin Cancer Res 13:6959-63. 2007
    ..Elevated cytoplasmic expression of HuR protein has been linked to carcinogenesis and is associated with reduced survival in breast, ovarian, and gastric adenocarcinomas...
  22. ncbi The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development
    Lars Hviid
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Vaccin 6:84-9. 2010
    There is substantial immuno-epidemiological evidence that the parasite-encoded, so-called variant surface antigens (VSAs), such as PfEMP1 on the surface of infected erythrocytes (IEs) are important-in some cases probably decisive ..
  23. pmc Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    Y Ishida
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    EMBO J 11:3887-95. 1992
    ..These results suggest that activation of the PD-1 gene may be involved in the classical type of programmed cell death...
  24. ncbi Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    Yoshinori Nagai
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Immunol 3:667-72. 2002
    ..Thus, MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4...
  25. pmc Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis
    Alan D Salama
    Laboratory of Immunogenetics and Transplantation, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 198:71-8. 2003
    ..Interestingly, PD-L2 but not PD-L1 blockade in WT animals also resulted in disease augmentation. Our data are the first demonstration that the PD-1 pathway plays a critical role in regulating EAE...
  26. pmc Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype
    K Mazan-Mamczarz
    Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Oncogene 27:6151-63. 2008
    ....
  27. pmc Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition
    Daniel P Depledge
    Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom
    PLoS Negl Trop Dis 4:e829. 2010
    ..Previous genome analysis has suggested that parasites of the sub-genus Leishmania (Viannia) have lost HASP genes from their genomes...
  28. ncbi NKT cells: what's in a name?
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Rev Immunol 4:231-7. 2004
  29. pmc Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants
    P C Bull
    Kenya Medical Research Institute CGMRC, Kilifi Unit, Kilifi, Kenya
    Infect Immun 67:733-9. 1999
    ..These results support the idea that preexisting anti-PfEMP1 antibodies can select the variants that are expressed during a new infection and may suggest the existence of a dominant subset of PfEMP1 variants...
  30. ncbi Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    J Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunity 12:71-81. 2000
    ..Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway...
  31. doi Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis
    R M Maizels
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh, UK
    Parasitology 136:1549-64. 2009
    ..The review concludes with a forward look to where we may make future advances towards the final eradication of helminth diseases...
  32. ncbi Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression
    K Miyake
    Department of Immunology, Saga Medical School, Japan
    J Immunol 161:1348-53. 1998
    ..Thus, MD-1 is physically associated with RP105 and is important for efficient cell surface expression...
  33. ncbi Posttranscriptional orchestration of an anti-apoptotic program by HuR
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 6:1288-92. 2007
    ....
  34. ncbi RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family
    K Miyake
    Department of Immunology, Saga Medical School, Japan
    J Immunol 154:3333-40. 1995
    ..These results demonstrate that RP105 is a novel member of the leucine-rich repeat protein family, and the first member that is specifically expressed on B cells...
  35. pmc Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
    Anke Doller
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Mol Cell Biol 28:2608-25. 2008
    ..Posttranslational modification of HuR by PKCdelta represents an important novel mode of HuR activation implied in renal COX-2 regulation...
  36. pmc Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions
    Keisuke Nagao
    Dermatology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:3312-7. 2009
    ..The presence of at least 3 functionally distinct skin DC subsets may have particular relevance for vaccines that are administered epicutaneously...
  37. ncbi Relief of microRNA-mediated translational repression in human cells subjected to stress
    Suvendra N Bhattacharyya
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, 4002 Basel, Switzerland
    Cell 125:1111-24. 2006
    ..We propose that proteins interacting with the 3'UTR will generally act as modifiers altering the potential of miRNAs to repress gene expression...
  38. pmc HuR regulates p21 mRNA stabilization by UV light
    W Wang
    Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell Biol 20:760-9. 2000
    ..Our findings indicate that HuR plays a major role in regulating stress-induced p21 expression by enhancing p21 mRNA stability and that these effects are coupled to HuR's elevated presence in the cytoplasm...
  39. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    ..By using a similar knockin strategy involving a diphtheria toxin receptor (DTR) fused to EGFP, we demonstrated that LCs were dispensable for triggering hapten-specific T cell effectors through skin immunization...
  40. ncbi The B7-CD28 superfamily
    Arlene H Sharpe
    Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 2:116-26. 2002
    ..Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential...
  41. pmc PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
    T Okazaki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan
    Proc Natl Acad Sci U S A 98:13866-71. 2001
    ..These results show that PD-1 can inhibit BCR signaling by recruiting SHP-2 to its phosphotyrosine and dephosphorylating key signal transducers of BCR signaling...
  42. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
    ..This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems...
  43. pmc Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2
    Anke Doller
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Mol Biol Cell 18:2137-48. 2007
    ..Regulation of HuR via PKC alpha-dependent phosphorylation emphasizes the importance of posttranslational modification for stimulus-dependent HuR shuttling...
  44. ncbi MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor
    Jean da Silva Correia
    Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
    J Biol Chem 277:1845-54. 2002
    ....
  45. ncbi Blood group terminology 2004: from the International Society of Blood Transfusion committee on terminology for red cell surface antigens
    G L Daniels
    Bristol Institute for Transfusion Sciences, Bristol, UK
    Vox Sang 87:304-16. 2004
  46. pmc HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites
    Jessica Keen
    Faculty of Medicine, University of Toronto, Toronto, Canada
    PLoS Med 4:e181. 2007
    ..Protection against PAM is associated with the production of IgG specific for variant surface antigens (VSA-PAM) expressed by chondroitin sulfate A (CSA)-adhering parasitized erythrocytes (PEs)...
  47. ncbi Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum
    Paul R Gilson
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Mol Cell Proteomics 5:1286-99. 2006
    ..Together this work identified 11 and predicted a further 19 GPI-anchored proteins in P. falciparum...
  48. pmc Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion
    Ute Woehlbier
    Zentrum für Molekulare Biologie ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Malar J 9:77. 2010
    ..Components of the MSP-1/6/7 complex and AMA-1 are presently under development as malaria vaccines...
  49. ncbi Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution
    R B Sutton
    The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Nature 395:347-53. 1998
    ..These characteristics may be important for membrane fusion and for the binding of regulatory factors affecting neurotransmission...
  50. ncbi Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults
    Salenna R Elliott
    Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
    Am J Trop Med Hyg 76:860-4. 2007
    Antibodies to variant surface antigens (VSA) including Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) have been associated with protective antimalarial immunity that appears to be variant-specific...
  51. ncbi BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood
    A Dzionek
    Miltenyi Biotec GmbH, Bergisch Gladbach, Germany AmCell Corporation, Sunnyvale, CA 94089, USA
    J Immunol 165:6037-46. 2000
    ..The three presumably novel Ags serve as specific markers for the respective subpopulations of blood dendritic cells in fresh blood and will be of great value for their further analysis and to evaluate their therapeutic potential...
  52. ncbi Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis
    Michael Miksa
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Shock 25:586-93. 2006
    ..We conclude that, by providing the indispensable factor MFG-E8 for complete engulfment of apoptotic cells, these exosomes lead to an attenuation of the systemic inflammatory response and overall beneficial effect in sepsis...
  53. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  54. ncbi Surface antigens of Toxoplasma gondii: variations on a theme
    C Lekutis
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Parasitol 31:1285-92. 2001
    ..Recently, it has become apparent that the number of surface antigens (SAGs) it expresses may rival the number of genera it can infect...
  55. ncbi Structure and function of hemidesmosomes: more than simple adhesion complexes
    L Borradori
    Department of Dermatology, DHURDV, University Hospital of Geneva, Switzerland
    J Invest Dermatol 112:411-8. 1999
    ..The aims of this review are to highlight the recent progresses of our knowledge on the organization and assembly of hemidesmosomes, their involvement in signaling pathways as well as their participation in clinical pathologic conditions...
  56. ncbi Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts
    D J Paterson
    MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, U K
    Mol Immunol 24:1281-90. 1987
    ..The phenotype of rat T blasts compared to resting cells was also examined and changes in expression of L-CA, Thy-1, OX-2 and CD8 antigens were seen in addition to the changes found with the above MAbs...
  57. ncbi Programmed death-1 targeting can promote allograft survival
    Engin Ozkaynak
    Millennium Pharmaceuticals, Cambridge, MA 02139, USA
    J Immunol 169:6546-53. 2002
    ....
  58. ncbi Lactadherin promotes VEGF-dependent neovascularization
    Jean Sebastien Silvestre
    Cardiovascular Research Center INSERM U689 Lariboisière, Universite Paris 7, Hopital Lariboisiere, 41 Bvd de la Chapelle, 75475 Paris Cedex 10, France
    Nat Med 11:499-506. 2005
    ..These results show a crucial role for lactadherin in VEGF-dependent neovascularization and identify lactadherin as an important target for the modulation of neovascularization...
  59. ncbi Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes
    C Nielsen
    Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    Tissue Antigens 62:492-7. 2003
    ..92]. The associated allele is previously shown to alter a transcription factor-binding site (RUNX1/AML1), and the results of this study suggest that this allele could act as an additional susceptibility allele to type 1 diabetes...
  60. ncbi Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses
    Spencer C Liang
    Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 33:2706-16. 2003
    ..PD-L2, but not PD-L1, expression was dramatically reduced in p50(-/-)p65(+/-) DC. Thus, PD-L1 and PD-L2 exhibit distinct expression patterns and are differentially regulated on the transcriptional level...
  61. ncbi Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex
    K M Misura
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Nature 404:355-62. 2000
    ..The structure also indicates mechanisms that might couple the action of upstream effector proteins to conformational changes in syntaxin 1a and nSec1 that lead to core complex formation and membrane fusion...
  62. pmc The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells
    Lionel Franz Poulin
    Centre d immunologie de Marseille Luminy, Universite de la Mediterrannee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 204:3119-31. 2007
    ..Our results stress that the langerin(+) DC network is more complex than originally thought and have implications for the development of transcutaneous vaccines and the improvement of humanized mouse models...
  63. ncbi Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritis
    Nicoletta Fiore
    Renal Unit, Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Piazza G Cesare 11, 70124 Bari, Italy
    Mol Immunol 45:259-65. 2008
    ..These results show for the first time that three DCs subsets, decreased at circulating levels, are recruited within the kidney, indicating that DCs might play a pathogenic role in SLE patients with nephritis...
  64. pmc Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE
    H R Katz
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 93:10809-14. 1996
    ..Our findings establish a novel counterregulatory transmembrane pathway by which mast cell activation can be inhibited...
  65. ncbi Long-term culture of human embryonic stem cells in feeder-free conditions
    Elen S Rosler
    Geron Corporation, Menlo Park, California, USA
    Dev Dyn 229:259-74. 2004
    ....
  66. doi Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21228, USA
    Biol Chem 389:243-55. 2008
    ....
  67. ncbi Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR
    Peter Pryzbylkowski
    Department of Medicine, Division of Molecular Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Rm 170 E and R Building, 401 Haddon Avenue, Camden, NJ 08103, USA
    Breast Cancer Res Treat 111:15-25. 2008
    ..Taken together, these data provide a novel anti-estrogenic mechanism for AZA and TSA in ER positive human breast cancer cells...
  68. ncbi Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
    L M Shaw
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 91:949-60. 1997
    ..The small G protein Rac is required downstream of PI3K for invasion. These studies define a mechanism by which the alpha6beta4 integrin promotes carcinoma invasion and invoke a novel function for PI3K signaling...
  69. pmc Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia
    Marie Laure Michel
    Unité Mixte de Recherche 8147, Centre National de la Recherche Scientifique, Faculté de Médecine René Descartes, Paris V, Hopital Necker, Paris, Cedex 15, France
    J Exp Med 204:995-1001. 2007
    ..Collectively, our findings reveal that NK1.1(neg) iNKT lymphocytes represent a new population of IL-17-producing cells that can contribute to neutrophil recruitment through preferential IL-17 secretion...
  70. ncbi Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells
    Christine Hostetter
    Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey 08106, USA
    Cancer Biol Ther 7:1496-506. 2008
    ..Our data describe a novel mechanism for the development of tamoxifen resistance and is the first study to identify an RNA binding protein as a key mediator of resistance in breast cancer cells...
  71. pmc Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium
    Heng Fu Bu
    Molecular and Cellular Pathobiology Program and Center for Digestive Disease and Immunobiology, Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    J Clin Invest 117:3673-83. 2007
    ....
  72. pmc PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells
    Vrajesh V Parekh
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 182:2816-26. 2009
    ..Collectively, our findings reveal a critical role for the PD-1/PD-L costimulatory pathway in the alphaGalCer-mediated induction of iNKT cell anergy that can be targeted for the development of immunotherapies...
  73. ncbi AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR
    Wengong Wang
    Laboratory of Cellular and Molecular Biology, NIA Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 279:48376-88. 2004
    ..Our results point to importin alpha1 as a critical downstream target of AMPK and key mediator of AMPK-triggered HuR nuclear import...
  74. ncbi Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Semin Cancer Biol 11:129-41. 2001
    ..Such studies have revealed novel insights into the mechanism of carcinoma invasion that involve both the dynamics of cell migration and signaling pathways that regulate this migration...
  75. ncbi Sperm protein 17 is a novel cancer-testis antigen in multiple myeloma
    S H Lim
    Center for Immunology and Microbial Disease and the Department of Medicine, Albany Medical College, Albany, NY 12208, USA
    Blood 97:1508-10. 2001
    ..Sp17 is therefore a novel member of the CT antigen family and should be an ideal target for immunotherapy of multiple myeloma...
  76. pmc Identification of a target RNA motif for RNA-binding protein HuR
    Isabel Lopez de Silanes
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:2987-92. 2004
    ..This study describes an HuR target RNA motif and presents a general strategy for identifying target motifs for RNA-binding proteins...
  77. ncbi Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production
    Julia A Brown
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:1257-66. 2003
    ..PD-L1 is also highly expressed on most carcinomas but minimally expressed on adjacent normal tissue suggesting a role in attenuating antitumor immune responses...
  78. pmc Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs
    Ashish Lal
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, MD 21224, USA
    EMBO J 23:3092-102. 2004
    ....
  79. doi Analysis of antibodies to neuronal surface antigens in adult opsoclonus-myoclonus
    L Sabater
    Service of Neurology, Hospital Clinic, Universitat de Barcelona, and Institut d Investigació Biomèdica August Pi i Sunye, Barcelona, Spain
    J Neuroimmunol 196:188-91. 2008
    Antibodies against neuronal surface antigens (NSA-ab) have been described in pediatric opsoclonus-myoclonus syndrome (OMS)...
  80. pmc Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells
    Corine H GeurtsvanKessel
    Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
    J Exp Med 205:1621-34. 2008
    ..Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus...
  81. ncbi Effect of long-term infection with nef-defective attenuated HIV type 1 on CD4+ and CD8+ T lymphocytes: increased CD45RO+CD4+ T lymphocytes and limited activation of CD8+ T lymphocytes
    J J Zaunders
    Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    AIDS Res Hum Retroviruses 15:1519-27. 1999
    ....
  82. pmc Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection
    Michael F Ofori
    Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Infect Immun 71:1584-6. 2003
    ..that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals...
  83. doi Insights into Langerhans cell function from Langerhans cell ablation models
    Daniel H Kaplan
    Department of Dermatology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    Eur J Immunol 38:2369-76. 2008
    ..This review highlights the similarities and differences between these mouse models, discusses the discovery and functional significance of Langerin(+) dermal DC, and examines some recent data that help to shed light on LC function...
  84. ncbi Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice
    D Yang
    Cancer Immunology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 S First Avenue, Maywood, IL 60153, USA
    Cancer Res 61:5857-60. 2001
    ..mSteap, mPsca, and mPsma constitute new tools for preventative and/or therapeutic vaccine construction and immune monitoring in the TRAMP mouse model that may provide insights into the treatment of human prostate cancer...
  85. ncbi Variable expression of activation-linked surface antigens on human mast cells in health and disease
    P Valent
    Department of Internal Medicine I, University of Vienna, Austria
    Immunol Rev 179:74-81. 2001
    ..MC also express a number of functionally important cell surface antigens, including stem cell factor receptor (SCFR=kit=CD117), high affinity IgER (FcepsilonRI), or CSaR (CD88)...
  86. ncbi The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells
    Shin Akakura
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 07103, Newark, NJ, USA
    Exp Cell Res 292:403-16. 2004
    ....
  87. ncbi Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses
    Fumihiko Tsushima
    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 33:2773-82. 2003
    ..Our results demonstrate the regulatory role of PD-1 and the differential roles of B7-H1 and B7-DC in hapten-induced immune responses. The PD-1-B7-H1 pathway may play a unique role in regulating inflammatory responses...
  88. pmc Highly polymorphic family of glycosylphosphatidylinositol-anchored surface antigens with evidence of developmental regulation in Toxoplasma gondii
    Angela M Pollard
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Infect Immun 76:103-10. 2008
    ..T. gondii has a superfamily of glycosylphosphatidylinositol (GPI)-anchored surface antigens, termed the surface antigen (SAG) and SAG-related surface antigens, that are developmentally regulated during ..
  89. pmc Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-associated malaria
    Anthony Jaworowski
    Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Clin Vaccine Immunol 16:312-9. 2009
    Human immunodeficiency virus type 1 (HIV-1) coinfection decreases antibodies to variant surface antigens implicated in pregnancy-associated malaria (VSA-PAM) caused by Plasmodium falciparum...
  90. ncbi Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
    Nicole Claudia Meisner
    Novartis Institutes for BioMedical Research, Discovery Technologies, Brunnerstr 59, A 1235 Vienna, Austria
    Nat Chem Biol 3:508-15. 2007
    ..MS-444, dehydromutactin and okicenone may become valuable tools for studying HuR function. An assessment of HuR inhibition as a central node in malignant processes might open up new conceptual routes toward combatting cancer...
  91. ncbi Novel antimicrobial peptide of human epididymal duct origin
    Hans Henning von Horsten
    IHF Institute for Hormone and Fertility Research at the University of Hamburg, D 22529 Hamburg, Germany
    Biol Reprod 67:804-13. 2002
    ....
  92. pmc Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:1524-9. 2009
    ..Therefore, anti-Langerin antibodies localize a majority of CD8(+) DCs to non-T cell regions of mouse spleen, where they are distinct from adjacent macrophages...
  93. ncbi Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor
    David B Rosen
    Department of Microbiology and Immunology, The Cancer Research Institute, and Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA
    J Immunol 175:7796-9. 2005
    ..Moreover, LLT1 on target cells can inhibit NK cytotoxicity via interactions with NKR-P1A...
  94. pmc Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytoplasmic membranes of Escherichia coli
    Suresh Yenugu
    Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7500, USA
    Biochem J 372:473-83. 2003
    ..coli membranes. A much longer exposure time was required for human beta-defensin-1-mediated permeabilization of membranes, suggesting a possible difference in mode of action compared with the HE2 antibacterial peptides...
  95. ncbi Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing
    Nobuyoshi Hiraoka
    Glycobiology Program, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:3058-67. 2004
    ....
  96. doi Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens
    Chun Hong Qiu
    RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    J Immunol 182:4127-36. 2009
    ..Transient ablation of this DC subset by cytochrome c injection resulted in a failure of tolerance induction to cell-associated Ags, indicating that this DC subset is essential for tolerance induction by apoptotic cell clearance...
  97. ncbi Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
    William R Heath
    Department of Immunology and The Cooperative Research Center for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Rev 199:9-26. 2004
    ..In this review, we examine the molecular basis for cross-presentation, discuss the role of DC subsets, and examine the contribution of this process to immunity, with some emphasis on DNA vaccination...
  98. pmc Phosphorylated HuR shuttles in cycles
    Hyeon Ho Kim
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 7:3124-6. 2008
    ..In this manner, HuR helps to schedule gene expression programs in a cell cycle-dependent manner...
  99. ncbi Activation-induced expression of human programmed death-1 gene in T-lymphocytes
    R Vibhakar
    Department of Pathology, New York Medical College, Elmsford 10523, USA
    Exp Cell Res 232:25-8. 1997
    ..These data suggest a role for hPD-1 during activation and differentiation of T-lymphocytes...
  100. pmc Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences
    Elizabeth J Fialcowitz-White
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 282:20948-59. 2007
    ..Together, the results define distinct roles for the HuR hinge and RRM3 domains in formation of cooperative HuR.ARE complexes in solution...
  101. pmc Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells
    Lan Xiao
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 18:4579-90. 2007
    ..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis...

Research Grants72

  1. SURFACE ANTIGENS OF ORAL BACTEROIDES SPECIES
    Ann Progulske Fox; Fiscal Year: 1993
    ..gingivalis HAs, determination of functional/virulence properties of the HAs and information concerning the receptor target molecules on the erythrocyte membrane...
  2. Nanopore Biosensor for Kinetics of Reparative Antibodies on Plasma Membranes
    Sang Hyun Oh; Fiscal Year: 2010
    ..in moving these reparative IgMs to clinical trial is to understand the kinetics of binding to the cell-surface antigens. Our hypothesis and preliminary data suggests that the mAbs do not bind to a single membrane molecule, but to ..
  3. Variant surface antigens and immunity to malaria
    James Burns; Fiscal Year: 2007
    ..We will focus on plasmodial proteins and variant surface antigens expressed on the reticulocyte surface, on their role in mediating adherence of pRBCs to vascular endothelium ..
  4. Variant surface antigens and immunity to malaria
    JAMES MATTHEW BURNS; Fiscal Year: 2010
    ..We will focus on plasmodial proteins and variant surface antigens expressed on the reticulocyte surface, on their role in mediating adherence of pRBCs to vascular endothelium ..
  5. NASAL COLONIZATION BY S AUREUS--MECHANISMS AND IMMUNITY
    Jean Lee; Fiscal Year: 2003
    ..goal of this study is to utilize this animal model to determine whether the expression of staphylococcal surface antigens influences the establishment of colonization...
  6. CANDIDA ALBICANS SURFACE ANTIGENS
    Jim Cutler; Fiscal Year: 1993
    ..Finally, we developed the techniques and tools to focus on this important host/C. albicans interaction and should be able to fulfill our intended goals...
  7. ISLET CELL MEMBRANE ANTIBODIES IN DIABETES
    Ake Lernmark; Fiscal Year: 1992
    ..Our hypothesis is that beta-cell specific surface antigens guide the immune-associated beta-cell attack...
  8. CANDIDA ALBICANS SURFACE ANTIGENS
    Jim Cutler; Fiscal Year: 1991
    The long term objectives are to characterize the surface antigens expressed by Candida albicans during in vitro and in vivo development, determine if monoclonal antibodies raised against these antigens may be used to biotype strains of C...
  9. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2003
    ..affects the immune system by altering monocyte accessory capacity, cytokine production, and expression of surface antigens/receptors involved in monocyte-T cell interactions...
  10. REGULATION OF HEPATITIS B VIRUS TRANSCRIPTION
    Alan McLachlan; Fiscal Year: 1993
    ..The cloning of the genes for these factors will permit the analysis of the mechanism by which these factors interact with their recognition sequences and influence the transcriptional activity of the HBV promoters...
  11. MECHANISMS OF IGE SYNTHESIS BY B CELLS
    Raif Geha; Fiscal Year: 2006
    ..The results of the proposed studies should have an important impact on the understanding and treatment of allergic and immunologic diseases. ..
  12. MECHANISMS OF IGE SYNTHESIS BY B CELLS
    Raif Geha; Fiscal Year: 2007
    ..and c). the MAP kinases p38 and JNK. The results of the proposed studies should have an important impact on the understanding and treatment of allergic and immunologic diseases. ..