surface antigens

Summary

Summary: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.

Top Publications

  1. ncbi Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3260-5. 2006
  2. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
  3. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
  4. ncbi HuR and mRNA stability
    C M Brennan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Cell Mol Life Sci 58:266-77. 2001
  5. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
  6. ncbi Characterization of human blood dendritic cell subsets
    Kelli P A MacDonald
    Dendritic Cell Laboratory, Mater Medical Research Institute, Mater Misericordiae Hospitals, South Brisbane, Australia
    Blood 100:4512-20. 2002
  7. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
  8. pmc MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    R Shimazu
    Department of Immunology, Saga Medical School, Saga, Japan
    J Exp Med 189:1777-82. 1999
  9. ncbi Expression of programmed death 1 ligands by murine T cells and APC
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:5538-45. 2002
  10. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007

Detail Information

Publications349 found, 100 shown here

  1. ncbi Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    Amanda L Blasius
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3260-5. 2006
    ..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC...
  2. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
    ..PD-L1 expression on nonlymphoid tissues and its potential interaction with PD-1 may subsequently determine the extent of immune responses at sites of inflammation...
  3. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
    ..These studies identify a specific mechanism of T-cell exhaustion and define a potentially effective immunological strategy for the treatment of chronic viral infections...
  4. ncbi HuR and mRNA stability
    C M Brennan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Cell Mol Life Sci 58:266-77. 2001
    ..The influence of newly identified protein ligands to HuR on HuR function in both normal and stressed cells may explain how ARE-mediated mRNA decay is regulated in response to environmental change...
  5. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  6. ncbi Characterization of human blood dendritic cell subsets
    Kelli P A MacDonald
    Dendritic Cell Laboratory, Mater Medical Research Institute, Mater Misericordiae Hospitals, South Brisbane, Australia
    Blood 100:4512-20. 2002
    ..These data provide an opportunity to standardize the DC populations used for future molecular, functional and possibly even therapeutic studies...
  7. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
  8. pmc MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    R Shimazu
    Department of Immunology, Saga Medical School, Saga, Japan
    J Exp Med 189:1777-82. 1999
    ..MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms...
  9. ncbi Expression of programmed death 1 ligands by murine T cells and APC
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:5538-45. 2002
    ..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
  10. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
    ..This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems...
  11. ncbi NKT cells: what's in a name?
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Rev Immunol 4:231-7. 2004
  12. ncbi Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    H Nishimura
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo, Kyoto, 606 8501, Japan
    Science 291:319-22. 2001
    ..These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases...
  13. ncbi The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses
    Beatriz M Carreno
    Genetics Institute Wyeth Research, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Annu Rev Immunol 20:29-53. 2002
    ..Understanding these pathways will allow development of new strategies for therapeutic intervention in immune-mediated diseases...
  14. pmc Protein ligands to HuR modulate its interaction with target mRNAs in vivo
    C M Brennan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Cell Biol 151:1-14. 2000
    ..We discuss the possible role of these ligands upstream of HuR in pathways that govern the stability of ARE-containing mRNAs...
  15. pmc Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    Yoshiko Iwai
    Department of Medical Chemistry, Graduate School of Medicine, Japan Science and Technology Corporation, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 99:12293-7. 2002
    ....
  16. ncbi Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    Yoshinori Nagai
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Immunol 3:667-72. 2002
    ..Thus, MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4...
  17. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  18. ncbi Relief of microRNA-mediated translational repression in human cells subjected to stress
    Suvendra N Bhattacharyya
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, 4002 Basel, Switzerland
    Cell 125:1111-24. 2006
    ..We propose that proteins interacting with the 3'UTR will generally act as modifiers altering the potential of miRNAs to repress gene expression...
  19. ncbi Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
    ..In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity...
  20. ncbi Delineation of mRNA export pathways by the use of cell-permeable peptides
    I E Gallouzi
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 294:1895-901. 2001
    ....
  21. pmc Phosphorylation of HuR by Chk2 regulates SIRT1 expression
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 25:543-57. 2007
    ..Our findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes...
  22. pmc Surface antigens of human embryonic stem cells: changes upon differentiation in culture
    Jonathan S Draper
    Department of Biomedical Science, University of Sheffield, UK
    J Anat 200:249-58. 2002
    ..The surface antigens characteristically expressed by hES cells were down-regulated following induction of differentiation and ..
  23. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    ..By using a similar knockin strategy involving a diphtheria toxin receptor (DTR) fused to EGFP, we demonstrated that LCs were dispensable for triggering hapten-specific T cell effectors through skin immunization...
  24. ncbi Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution
    R B Sutton
    The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Nature 395:347-53. 1998
    ..These characteristics may be important for membrane fusion and for the binding of regulatory factors affecting neurotransmission...
  25. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...
  26. pmc RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
    Stefanie Galban
    LCMB, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Mol Cell Biol 28:93-107. 2008
    ..Conversely, HIF-1alpha expression and translation in response to CoCl(2) were markedly elevated after HuR overexpression. We propose that HuR and PTB jointly upregulate HIF-1alpha translation in response to CoCl(2)...
  27. pmc The quantity and quality of African children's IgG responses to merozoite surface antigens reflect protection against Plasmodium falciparum malaria
    David Courtin
    Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e7590. 2009
    ..Evaluating such responses in longitudinal sero-epidemiological field studies, allied to increasing knowledge of the immunological mechanisms associated with anti-malarial protection, will help in the development of malaria vaccines...
  28. ncbi PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2
    LauraL Carter
    Wyeth Genetics Institute, Cambridge, MA 02140, USA
    Eur J Immunol 32:634-43. 2002
    ..However, CD8(+) T cells may be more sensitive to modulation by the PD-1:PD-L pathway because of their intrinsic inability to produce significant levels of IL-2...
  29. ncbi Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Clin Cancer Res 10:5580-6. 2004
    ..Cell culture studies have shown that the mRNA of cyclooxygenase (COX)-2 can be stabilized by HuR...
  30. ncbi Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21228, USA
    Biol Chem 389:243-55. 2008
    ....
  31. ncbi Prognostic role of HuR in hereditary breast cancer
    Mira Heinonen
    Department of Pathology HUSLAB and Haartman Institute, Helsinki University Central Hospital, Finland
    Clin Cancer Res 13:6959-63. 2007
    ..Elevated cytoplasmic expression of HuR protein has been linked to carcinogenesis and is associated with reduced survival in breast, ovarian, and gastric adenocarcinomas...
  32. pmc Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    Y Ishida
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    EMBO J 11:3887-95. 1992
    ..These results suggest that activation of the PD-1 gene may be involved in the classical type of programmed cell death...
  33. pmc Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis
    Alan D Salama
    Laboratory of Immunogenetics and Transplantation, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 198:71-8. 2003
    ..Interestingly, PD-L2 but not PD-L1 blockade in WT animals also resulted in disease augmentation. Our data are the first demonstration that the PD-1 pathway plays a critical role in regulating EAE...
  34. pmc The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
    Mohammed Javeed I Ansari
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 198:63-9. 2003
    ....
  35. pmc Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway
    Brian T Fife
    UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, and Transplantation Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 203:2737-47. 2006
    ....
  36. ncbi Phase 1 vaccine trial of Pvs25H: a transmission blocking vaccine for Plasmodium vivax malaria
    Elissa M Malkin
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Twinbrook 1, Room 1123, Rockville, MD 20852, USA
    Vaccine 23:3131-8. 2005
    ..Pvs25H generates transmission blocking immunity in humans against P. vivax demonstrating the potential of this antigen as a component of a transmission blocking vaccine...
  37. pmc Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
    J Ohnishi
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 98:670-5. 2001
    ..burgdorferi transmission. Implicit in our model is the concept that tick transmission converts a homogeneous spirochete population into a heterogeneous population that is poised to infect the mammalian host...
  38. pmc Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants
    P C Bull
    Kenya Medical Research Institute CGMRC, Kilifi Unit, Kilifi, Kenya
    Infect Immun 67:733-9. 1999
    ..These results support the idea that preexisting anti-PfEMP1 antibodies can select the variants that are expressed during a new infection and may suggest the existence of a dominant subset of PfEMP1 variants...
  39. pmc Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition
    Daniel P Depledge
    Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom
    PLoS Negl Trop Dis 4:e829. 2010
    ..Previous genome analysis has suggested that parasites of the sub-genus Leishmania (Viannia) have lost HASP genes from their genomes...
  40. pmc Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype
    K Mazan-Mamczarz
    Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Oncogene 27:6151-63. 2008
    ....
  41. ncbi Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis
    R M Maizels
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh, UK
    Parasitology 136:1549-64. 2009
    ..The review concludes with a forward look to where we may make future advances towards the final eradication of helminth diseases...
  42. ncbi Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes
    C Nielsen
    Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    Tissue Antigens 62:492-7. 2003
    ..92]. The associated allele is previously shown to alter a transcription factor-binding site (RUNX1/AML1), and the results of this study suggest that this allele could act as an additional susceptibility allele to type 1 diabetes...
  43. ncbi Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria
    Ali Salanti
    Centre for Medical Parasitology at the Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Denmark
    Mol Microbiol 49:179-91. 2003
    Cytoadhesion of infected red blood cells (iRBC) is mediated through parasite-encoded, clonally variant surface antigens (VSA) and is a central process in the pathogenesis of Plasmodium falciparum malaria...
  44. ncbi Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    J Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunity 12:71-81. 2000
    ..Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway...
  45. ncbi Surface antigens of Toxoplasma gondii: variations on a theme
    C Lekutis
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Parasitol 31:1285-92. 2001
    ..Recently, it has become apparent that the number of surface antigens (SAGs) it expresses may rival the number of genera it can infect...
  46. ncbi Posttranscriptional orchestration of an anti-apoptotic program by HuR
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 6:1288-92. 2007
    ....
  47. ncbi Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression
    K Miyake
    Department of Immunology, Saga Medical School, Japan
    J Immunol 161:1348-53. 1998
    ..Thus, MD-1 is physically associated with RP105 and is important for efficient cell surface expression...
  48. pmc Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
    Anke Doller
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Mol Cell Biol 28:2608-25. 2008
    ..Posttranslational modification of HuR by PKCdelta represents an important novel mode of HuR activation implied in renal COX-2 regulation...
  49. pmc Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions
    Keisuke Nagao
    Dermatology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:3312-7. 2009
    ..The presence of at least 3 functionally distinct skin DC subsets may have particular relevance for vaccines that are administered epicutaneously...
  50. ncbi Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    H Nishimura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:141-51. 1999
    ..Collectively, it is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses...
  51. pmc Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigens
    Michael F Ofori
    Immunology and Epidemiology Units, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Infect Immun 70:2982-8. 2002
    ..during childhood in parallel with acquisition of agglutinating antibodies to parasite-encoded variant surface antigens (VSA) expressed on parasitized red blood cells...
  52. pmc PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
    T Okazaki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan
    Proc Natl Acad Sci U S A 98:13866-71. 2001
    ..These results show that PD-1 can inhibit BCR signaling by recruiting SHP-2 to its phosphotyrosine and dephosphorylating key signal transducers of BCR signaling...
  53. pmc HuR regulates p21 mRNA stabilization by UV light
    W Wang
    Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell Biol 20:760-9. 2000
    ..Our findings indicate that HuR plays a major role in regulating stress-induced p21 expression by enhancing p21 mRNA stability and that these effects are coupled to HuR's elevated presence in the cytoplasm...
  54. ncbi The B7-CD28 superfamily
    Arlene H Sharpe
    Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 2:116-26. 2002
    ..Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential...
  55. pmc Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2
    Anke Doller
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Mol Biol Cell 18:2137-48. 2007
    ..Regulation of HuR via PKC alpha-dependent phosphorylation emphasizes the importance of posttranslational modification for stimulus-dependent HuR shuttling...
  56. ncbi Identification of a factor that links apoptotic cells to phagocytes
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Nature 417:182-7. 2002
    ..These results indicate that MFG-E8 secreted from activated macrophages binds to apoptotic cells, and brings them to phagocytes for engulfment...
  57. pmc Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector
    James M Battisti
    Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:5228-37. 2008
    ..We conclude that OspA serves a critical antibody-shielding role during vector blood meal uptake from immune hosts and is not required for persistence in the tick vector...
  58. ncbi Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs
    Tongtong Zou
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    J Biol Chem 281:19387-94. 2006
    ..These results indicate that polyamines modulate cytoplasmic HuR levels in intestinal epithelial cells, in turn controlling the stability of the NPM and p53 mRNAs and influencing NPM and p53 protein levels...
  59. ncbi Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5
    Swapan K Dasgupta
    Department of Pathology and Medicine Thrombosis Research, Baylor College of Medicine, Houston, Texas, USA
    Transl Res 148:19-25. 2006
    ..Lactadherin, a glycoprotein secreted by macrophages, binds to phosphatidylserine on apoptotic cells and promote their clearance by macrophages...
  60. pmc Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR
    Ana Rebane
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    RNA 10:590-9. 2004
    ..Possible nucleocytoplasmic shuttling mechanisms for hnRNP A1 and HuR are discussed...
  61. ncbi Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi
    T G Schwan
    Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Biochem Soc Trans 31:108-12. 2003
    ..Future experiments in ticks with mutant spirochaetes that lack these proteins should clarify the speculative functions currently given to these proteins...
  62. pmc Transportin2 functions as importin and mediates nuclear import of HuR
    Stephan Güttinger
    Swiss Federal Institute of Technology, Institute of Biochemistry, HPM F11 1, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 101:2918-23. 2004
    ..Finally, crosscompetition experiments demonstrated that HuR nucleocytoplasmic shuttling signal and M9 are imported along redundant pathways involving TRN1/2, substantiating the function of TRN2 in nuclear import...
  63. pmc Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses
    Fang Ting Liang
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
    Infect Immun 72:5759-67. 2004
    ..This change in antigenic expression could be induced by passively immunizing infected severe combined immunodeficiency mice with specific Borrelia antisera or OspC antibody and appears to allow B. burgdorferi to resist immune attack...
  64. ncbi The leukocyte/neuron cell surface antigen OX2 binds to a ligand on macrophages
    S Preston
    MCR Cellular Immunology Unit, Sir William Dunn School of Pathology, Oxford, GB
    Eur J Immunol 27:1911-8. 1997
    ..The OX2 antigen is present on thymocytes, some lymphocytes, neurons and endothelial cells; thus, it has the potential to mediate interactions between these cell types and macrophages...
  65. pmc Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor
    Tahiro Shin
    Sidneu Kimmel Comprehensive Cancer Centre, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Exp Med 198:31-8. 2003
    ..Finally, costimulation with B7-DC alone or in conjunction with B7-1 is PD-1 independent, indicating that B7-DC costimulates T cells via a second receptor...
  66. pmc p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Cell Biol 147:1063-72. 1999
    ..These studies demonstrate that the p53 tumor suppressor can inhibit integrin-associated survival signaling pathways...
  67. ncbi Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets
    Karine Crozat
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Immunol Rev 234:177-98. 2010
    ....
  68. pmc Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences
    Qilong Xu
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Mol Microbiol 69:15-29. 2008
    ..Taken together, the study demonstrated that the surface lipoproteins provide B. burgdorferi with an essential protective function against host innate elimination...
  69. ncbi Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells
    Marcel H A M Fens
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Blood 111:4542-50. 2008
    ..Implications of our findings for diagnostic and therapy of angiogenesis-driven diseases are discussed...
  70. ncbi Isolation and characterization of multipotential mesenchymal stem cells from feline bone marrow
    Douglas R Martin
    The Scott Ritchey Research Center, College of Veterinary Medicine, Auburn University, Ala 36849, USA
    Exp Hematol 30:879-86. 2002
    ..Therefore, the objective of this study was to characterize mesenchymal stem cells (MSC) from feline bone marrow for use in research on the application of stem cells to human health problems for which cats are the preferred model...
  71. ncbi Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens
    J K Henderson
    Section of Reproductive Biology, The School of Medicine and Biomedical Science and Department of Biomedical Science, Univeristy of Sheffield, Sheffield, UK
    Stem Cells 20:329-37. 2002
    Cell-surface antigens provide invaluable tools for the identification of cells and for the analysis of cell differentiation...
  72. ncbi IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR
    Esther A Suswam
    Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA
    Int J Cancer 113:911-9. 2005
    ..the destabilizing factor KSRP. In conclusion, IL-1beta is a potent cytokine stimulus for IL-8 RNA stabilization in breast cancer cells, possibly by enhanced binding of cytoplasmic HuR to the 3'UTR...
  73. ncbi MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor
    Jean da Silva Correia
    Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
    J Biol Chem 277:1845-54. 2002
    ....
  74. pmc HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites
    Jessica Keen
    Faculty of Medicine, University of Toronto, Toronto, Canada
    PLoS Med 4:e181. 2007
    ..Protection against PAM is associated with the production of IgG specific for variant surface antigens (VSA-PAM) expressed by chondroitin sulfate A (CSA)-adhering parasitized erythrocytes (PEs)...
  75. ncbi Blood group terminology 2004: from the International Society of Blood Transfusion committee on terminology for red cell surface antigens
    G L Daniels
    Bristol Institute for Transfusion Sciences, Bristol, UK
    Vox Sang 87:304-16. 2004
  76. ncbi Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum
    Paul R Gilson
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Mol Cell Proteomics 5:1286-99. 2006
    ..Together this work identified 11 and predicted a further 19 GPI-anchored proteins in P. falciparum...
  77. pmc Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion
    Ute Woehlbier
    Zentrum für Molekulare Biologie ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Malar J 9:77. 2010
    ..Components of the MSP-1/6/7 complex and AMA-1 are presently under development as malaria vaccines...
  78. pmc Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells
    I Rabinovitz
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cell Biol 146:1147-60. 1999
    ....
  79. pmc B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    S Y Tseng
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Exp Med 193:839-46. 2001
    ..These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses...
  80. pmc alpha3beta1 Integrin is required for normal development of the epidermal basement membrane
    C M DiPersio
    Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 137:729-42. 1997
    ..Our findings support a novel role for alpha3beta1 in establishment and/or maintenance of basement membrane integrity, while alpha6beta4 is required for stable adhesion of the epidermis to the basement membrane through hemidesmosomes...
  81. ncbi Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults
    Salenna R Elliott
    Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
    Am J Trop Med Hyg 76:860-4. 2007
    Antibodies to variant surface antigens (VSA) including Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) have been associated with protective antimalarial immunity that appears to be variant-specific...
  82. ncbi Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts
    D J Paterson
    MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, U K
    Mol Immunol 24:1281-90. 1987
    ..The phenotype of rat T blasts compared to resting cells was also examined and changes in expression of L-CA, Thy-1, OX-2 and CD8 antigens were seen in addition to the changes found with the above MAbs...
  83. ncbi Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis
    Michael Miksa
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Shock 25:586-93. 2006
    ..We conclude that, by providing the indispensable factor MFG-E8 for complete engulfment of apoptotic cells, these exosomes lead to an attenuation of the systemic inflammatory response and overall beneficial effect in sepsis...
  84. ncbi Structure and function of hemidesmosomes: more than simple adhesion complexes
    L Borradori
    Department of Dermatology, DHURDV, University Hospital of Geneva, Switzerland
    J Invest Dermatol 112:411-8. 1999
    ..The aims of this review are to highlight the recent progresses of our knowledge on the organization and assembly of hemidesmosomes, their involvement in signaling pathways as well as their participation in clinical pathologic conditions...
  85. ncbi Programmed death-1 targeting can promote allograft survival
    Engin Ozkaynak
    Millennium Pharmaceuticals, Cambridge, MA 02139, USA
    J Immunol 169:6546-53. 2002
    ....
  86. ncbi BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood
    A Dzionek
    Miltenyi Biotec GmbH, Bergisch Gladbach, Germany AmCell Corporation, Sunnyvale, CA 94089, USA
    J Immunol 165:6037-46. 2000
    ..The three presumably novel Ags serve as specific markers for the respective subpopulations of blood dendritic cells in fresh blood and will be of great value for their further analysis and to evaluate their therapeutic potential...
  87. ncbi Lactadherin promotes VEGF-dependent neovascularization
    Jean Sebastien Silvestre
    Cardiovascular Research Center INSERM U689 Lariboisière, Universite Paris 7, Hopital Lariboisiere, 41 Bvd de la Chapelle, 75475 Paris Cedex 10, France
    Nat Med 11:499-506. 2005
    ..These results show a crucial role for lactadherin in VEGF-dependent neovascularization and identify lactadherin as an important target for the modulation of neovascularization...
  88. ncbi Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses
    Spencer C Liang
    Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 33:2706-16. 2003
    ..PD-L2, but not PD-L1, expression was dramatically reduced in p50(-/-)p65(+/-) DC. Thus, PD-L1 and PD-L2 exhibit distinct expression patterns and are differentially regulated on the transcriptional level...
  89. ncbi Long-term culture of human embryonic stem cells in feeder-free conditions
    Elen S Rosler
    Geron Corporation, Menlo Park, California, USA
    Dev Dyn 229:259-74. 2004
    ....
  90. pmc The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells
    Lionel Franz Poulin
    Centre d immunologie de Marseille Luminy, Universite de la Mediterrannee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 204:3119-31. 2007
    ..Our results stress that the langerin(+) DC network is more complex than originally thought and have implications for the development of transcutaneous vaccines and the improvement of humanized mouse models...
  91. ncbi Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex
    K M Misura
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Nature 404:355-62. 2000
    ..The structure also indicates mechanisms that might couple the action of upstream effector proteins to conformational changes in syntaxin 1a and nSec1 that lead to core complex formation and membrane fusion...
  92. ncbi Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritis
    Nicoletta Fiore
    Renal Unit, Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Piazza G Cesare 11, 70124 Bari, Italy
    Mol Immunol 45:259-65. 2008
    ..These results show for the first time that three DCs subsets, decreased at circulating levels, are recruited within the kidney, indicating that DCs might play a pathogenic role in SLE patients with nephritis...
  93. pmc Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE
    H R Katz
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 93:10809-14. 1996
    ..Our findings establish a novel counterregulatory transmembrane pathway by which mast cell activation can be inhibited...
  94. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
    ..Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization...
  95. pmc Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation
    Wijdan Al-Ahmadi
    Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Nucleic Acids Res 37:3612-24. 2009
    ..The study shows that the HuR gene codes for several polyadenylation variants differentially regulated by AU-rich elements, and demonstrates an auto-regulatory role of HuR...
  96. ncbi Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Science 304:1147-50. 2004
    ..These data demonstrate that MFG-E8 has a critical role in removing apoptotic B cells in the germinal centers and that its failure can lead to autoimmune diseases...
  97. pmc Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction
    Shengdian Wang
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 197:1083-91. 2003
    ..Our results reveal unique binding characteristics of B7-H1 and B7-DC and provide direct evidence for an independent costimulatory receptor other than PD-1...
  98. ncbi RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family
    K Miyake
    Department of Immunology, Saga Medical School, Japan
    J Immunol 154:3333-40. 1995
    ..These results demonstrate that RP105 is a novel member of the leucine-rich repeat protein family, and the first member that is specifically expressed on B cells...
  99. ncbi The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development
    Lars Hviid
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Vaccin 6:84-9. 2010
    There is substantial immuno-epidemiological evidence that the parasite-encoded, so-called variant surface antigens (VSAs), such as PfEMP1 on the surface of infected erythrocytes (IEs) are important-in some cases probably decisive ..
  100. pmc Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization
    Chyi Ying A Chen
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, Texas 77030, USA
    Mol Cell Biol 22:7268-78. 2002
    ..Our data suggest that the ARE-binding specificity of HuR in vivo is modulated to interact only with and thus regulate specific AREs in a cell type- and physiological state-dependent manner...
  101. ncbi Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice
    Yasuhiro Yamaguchi
    Division of Integrative Cell Biology, Department of Embryogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    J Immunol 169:2516-23. 2002
    ..Our findings indicated that multiple beta-defensin isoforms specifically and cooperatively contribute to the innate immunity of the urogenital system...

Research Grants69

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  3. Salmonella Vaccines Against Bacterial Enteropathogens
    Roy Curtiss; Fiscal Year: 2013
    ..Paratyphi A strains with regulated delayed attenuation attributes to expose and display cross-protective surface antigens, that minimize induction of immune responses to serotype-specific antigens, that possess mutations to enhance ..
  4. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ....
  5. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..Development of a safe, needle-free, easy-to-administer and highly effective nanoemulsion-based vaccine would have great value for use as a therapeutic agent against chronic HBV infection in the United States and globally. ..
  6. Fic-mediated Adenylylation
    CAROLYN ANN WORBY; Fiscal Year: 2013
    ..This covalent addition of AMP blocks signal transduction pathways in the host that are important for combating bacterial infections. ..
  7. Characterize functions of T. brucei RAP1 and TRF in antigenic variation and telom
    Bibo Li; Fiscal Year: 2013
    ..Identification of novel factors involved in antigenic variation also provides more potential targets for anti-parasite drugs and helps for eventual elimination of this parasite. ..
  8. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..from the leukocyte and endothelial cell forms a tether between them and allows the leukocyte's cell surface antigens to interact with those of the endothelial cell. This is followed by cell:cell interactions such as diapedesis...
  9. Endemic maintenance of relapsing fever genotypes.
    Michael Bela Teglas; Fiscal Year: 2013
    ..the relapsing fever spirochete avoids host immunity and hence natural selection via hypervariability in major surface antigens, namely expressed vmp (vsp and vlp) genes...
  10. The Roles of Conserved outer-membrane proteins in SFG rickettsia pathogenesis
    Juan J Martinez; Fiscal Year: 2013
    ..iii. We will also determine the roles of conserved surface antigens, namely rOmpA, Sca1 and Sca2 in mediating invasion of non-phagocytic mammalian cells...
  11. Novel Therapeutic Vaccines for Chronic HBV
    ROBERT GERALD WHALEN; Fiscal Year: 2013
    ..Success in developing this innovative DNA-based therapeutic vaccine for chronic HBV infection would fill a considerable unmet need in the treatment of this disease, which represents a major public health burden. ..
  12. Cytosine DNA Methylation and Transcriptional Repression in African Trypanosomes
    KEVIN MILITELLO; Fiscal Year: 2012
    ..DNA methylation in Trypanosoma brucei may reveal the mechanism by which the parasites regulate expression of surface antigens and evade the human immune system...
  13. System for Rapid Generation of Aptamers for Transplant Therapies
    KAREN QIAN; Fiscal Year: 2010
    ....
  14. Isolation of novel mesenchymal stem cell subpopulations
    Buddhadeb Dawn; Fiscal Year: 2009
    ..The results of the proposed studies will therefore be highly relevant for improving public health, and improving the length and quality of life of millions of patients with ischemic heart disease and heart failure. ..
  15. FUNCTION OF THE KINETOPLAST IN THE HEMOFLAGELLATES
    Larry Simpson; Fiscal Year: 2013
    ....
  16. Campylobacter jejuni outer membrane protein vaccine
    Stuart Thompson; Fiscal Year: 2009
    ..jejuni surface antigens. An effective vaccine against C. jejuni is therefore highly desirable, to protect the U.S...
  17. Toxoplasma Epigenomics and Gene Expression
    Kami Kim; Fiscal Year: 2013
    ..In response to stress and changes in its environment, the parasite completely alters its metabolism, surface antigens, and cell cycle to transition from tachyzoite to bradyzoite. Understanding how T...
  18. Nanopore Biosensor for Kinetics of Reparative Antibodies on Plasma Membranes
    Sang Hyun Oh; Fiscal Year: 2013
    ..in moving these reparative IgMs to clinical trial is to understand the kinetics of binding to the cell-surface antigens. Our hypothesis and preliminary data suggests that the mAbs do not bind to a single membrane molecule, but to ..
  19. Norovirus P Particle, A Multifunctional Platform For Vaccine Development
    Ming Tan; Fiscal Year: 2012
    ..Through these studies we wish to further build up confidence on our research which may help to speed up the process of commercialization of the P particle vaccine platform for a broad application by many laboratories around world. ..
  20. CENTER FOR CANCER BIOLOGY RESEARCH
    W Keith Miskimins; Fiscal Year: 2011
    ..Project 3 (Satoshi Nagata, PhD) will develop a panel of monoclonal antibodies to surface antigens that are highly expressed in B cell malignancies...
  21. Impact of Vaccination against GM2, GD2 and GD3 on Disease Free Survival in Resect
    Wolfgang W Scholz; Fiscal Year: 2012
    ..Three cell surface antigens most relevant for a sarcoma vaccine and uniquely over-expressed in all types of sarcomas were identified as ..
  22. P.falciparum var gene diversity and malaria control
    KAREN PATRICIA DAY; Fiscal Year: 2013
    ..Defining the reservoir of infection by measuring var diversity is a critical step for malaria control in the new era of malaria eradication. ..
  23. Occult Hepatitis B Infection in South African HIV Patients
    Jason T Blackard; Fiscal Year: 2012
    ....
  24. CENTER FOR CANCER BIOLOGY RESEARCH
    W Keith Miskimins; Fiscal Year: 2013
    ..Project 3 (Satoshi Nagata, PhD) will develop a panel of monoclonal antibodies to surface antigens that are highly expressed in B cell malignancies...
  25. The role of Variable Erythrocyte Surface Antigen (VESA1) proteins in Babesia bovi
    KERRY SUE SONDGEROTH; Fiscal Year: 2011
    ....
  26. Targeted therapy of pancreatic cancer with in vivo radionuclide generator
    Ekaterina Dadachova; Fiscal Year: 2012
    ..Targeting of intracellular antigens (IntAs) was pioneered by Dr. A. Epstein as an alternative to targeting surface antigens in RIT...
  27. Mechanisms of Mycoplasmal Disease Pathogenesis
    KEVIN F DYBVIG; Fiscal Year: 2013
    ..These studies will lead to the development of new approaches for the control of mycoplasmal infections, such as the targeting of the polysaccharides or the machinery for their synthesis. ..
  28. Low Cost Multi-pathogen Laser Diagnostic for HIV and AIDS Co-Infections
    CHRISTOPHER JOHN MYATT; Fiscal Year: 2011
    ..The simplicity and low cost of the technology will facilitate the use of antiretroviral therapy, greatly prolonging the lives of those infected with HIV and reducing the burden of disease in populations where HIV is endemic. ..
  29. Niche-induced Signaling in Progenitor B Cell Development
    LESLIE ERIC SILBERSTEIN; Fiscal Year: 2013
    ..LSC, in conjunction with fluorescent immunostaining of surface antigens for progenitor B and niche cells, will objectively quantify the relative frequency that Fak wt and Fak -/- ..
  30. Optimized magnetic nanoparticle labels for ultra-sensitive sepsis diagnostics
    MARK S DIIORIO; Fiscal Year: 2011
    ..detection platform where magnetic nanoparticles are attached to antibodies that bind with high specificity to surface antigens on target bacteria...
  31. Structural insights into pandemic and emerging influenza viruses
    Ian A Wilson; Fiscal Year: 2013
    ..exhibit extreme diversity via multiple serotypes of the hemagglutinin (HA 1-16) and neuraminidase (NA 1-9) surface antigens. To date, only three of the possible 144 combinations found in bird and animal reservoirs have been ..
  32. PRODUCT DEVELOPMENT OF A MEMBRANE TETRASPANIN VACCINE AGAINST SCHISTOSOMIASIS
    CHARLES RUSSELL MIDDAUGH; Fiscal Year: 2011
    ..abstract_text> ..
  33. Use of Genetically Engineered T cells Targeting Tumor Stroma to Treat Lung Cancer
    STEVEN MARK ALBELDA; Fiscal Year: 2013
    ..to combine the effector functions of T lymphocytes with the ability of antibodies to recognize pre-defined surface antigens with high specificity in a non-MHC restricted manner...
  34. Rapid, Point-of-Care Diagnosis of Neonatal Sepsis
    GREGORY SOMMER; Fiscal Year: 2013
    ..LBP), chemokines and cytokines (IL-6, IL-8, TNF[unreadable]), hematologic parameters (WBC counts) and cell surface antigens (CD64, CD11b, HLA-DR, CTLA-4)...
  35. MicroPET/SPECT/CT animal imaging device for translational research
    Eugene Fine; Fiscal Year: 2010
    ..2) Radioimmunotherapy (RIT) targeted to specific lymphoid surface antigens in HIV;and to cryptococcal surface antigens for this opportunistic infection;both innovative techniques ..
  36. CyTOF Mass Cytometer for Western New York
    Timothy P Bushnell; Fiscal Year: 2012
    ....
  37. Designer antigen receptors to re-direct T cells to the NY-ESO-1 tumor antigen
    MARCELA VALDERRAMA MAUS; Fiscal Year: 2013
    ..T cell therapy with cells transduced with chimeric antigen receptors that re-direct them toward native surface antigens. Here, the candidate proposes to expand the concept of chimeric antigen receptors by targeting a cytoplasmic ..
  38. Treatment of Breast Cancer with MAG-1 Antibody
    Roy H L Pang; Fiscal Year: 2010
    ..The proposed research is expected to lead to new and successful therapeutic approaches for managing breast cancer, thereby leading to a higher survival rate of the patients. ..
  39. Cellular processing and role of a surface antigen in borrelial pathogenesis
    Xiuli Yang; Fiscal Year: 2013
    ..This study will shed new light on the mechanism of spirochete pathogenesis and may also help the development of novel preventive measures against Lyme disease. ..
  40. Paraneoplastic Disorders of the CNS: Autoantigen Profiling
    Josep O Dalmau; Fiscal Year: 2013
    ..the intracellular antigens are important as surrogate diagnostic markers of PND and specific tumors, the cell surface antigens are notable for 4 reasons: 1) the associated disorders can occur with or without cancer and affect young ..
  41. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary R Galinski; Fiscal Year: 2012
    ....
  42. A novel anti-spore nasal vaccine for protection from anthrax
    Amy Rasley; Fiscal Year: 2013
    ..In this proposal, we will generate a novel B. anthracis vaccine, directed against multiple spore-surface antigens and protective antigen (PA), using nanolipoprotein particle (NLP) technology...
  43. Multifunctional class I transcription in T. brucei
    ARTHUR GUNZL; Fiscal Year: 2013
    ..factors that are indispensable for the lethal parasite Trypanosoma brucei to express its major cell surface antigens and to survive in its human and vector hosts. Accordingly, these factors are essential for parasite growth...
  44. Evolution of chronic infection in Anasplasma phagocytophilum
    Anthony F Barbet; Fiscal Year: 2010
    ..interact with host immunity by recombination of functional pseudogenes into expression sites needing major surface antigens. These organisms represent valuable models for the study of coevolution because of variable levels of natural ..
  45. DNA repair and recombination within the var gene family of P. falciparum
    Kirk W Deitsch; Fiscal Year: 2013
    ..and to determine how DNA repair pathways contribute to diversification of the genes encoding their primary surface antigens. To address these objectives, a regulatable, site-specific endonuclease system has been adapted for use in ..
  46. Genetic Variation in genes involved in Neisseria gonorrhoeae LOS biosynthesis
    Daniel C Stein; Fiscal Year: 2013
    ....
  47. Characterization of prostatic stem cells and prostate cancer-initiating cells
    Li Xin; Fiscal Year: 2012
    ..B) We will continue to screen the expression of surface antigens in prostate, fractionate prostate cells using surface antigens and identify the fraction(s) with enriched ..
  48. Impact of seasonality and vector control on population structure of P.falciparum
    Mercedes Pascual; Fiscal Year: 2013
    ..This outcome ofthe project could lead to real innovation in malaria surveillance, control and elimination strategies. ..
  49. Role of VprBP in B cell development and V(D)J recombination
    Patrick C Swanson; Fiscal Year: 2013
    ....
  50. Genome Variability and Population Processes of Lyme Disease Pathogens
    Weigang Qiu; Fiscal Year: 2013
    ..The project helps to control the spread of Lyme disease by identifying virulence genes and by predicting pathogen spread in nature. ..
  51. Adult Stem Cells: Osteoblast Differentiation and Engraftment
    David W Rowe; Fiscal Year: 2011
    ..and enrich for the cells responsible for optimal osteogenesis will be pursued by FACS sorting based on surface antigens or expression of promoter - GFP transgenes active during early lineage development...
  52. Lentiviral expression of MHC II antigens at the maternal-fetal interface
    Stephen A Brown; Fiscal Year: 2010
    ..to manipulate gene expression in extraembryonic tissues in order to force the aberrant expression of MHC II surface antigens at the maternal-fetal interface in mice...
  53. Harnessing Human DC Subsets for Improved Muscosal Vaccines
    Gerard Zurawski; Fiscal Year: 2013
    ..We view the candidate vaccine as a bispecific antibody a) binding to two different cell surface antigens, such as specific lectin for antigen delivery and CD40 for activation, or to two different DC subsets, to ..
  54. Assembly of phi29 pRNA nanoparticles for siRNA delivery to prostate cancer cells
    Peixuan Guo; Fiscal Year: 2012
    ..be exploited to construct polyvalent pRNA vehicles carrying an RNA aptamer to specifically bind to prostate surface antigens and a therapeutic siRNA targeting an anti-apoptosis factor for the prostate cancer treatment...
  55. Hetero-dimerization-activated Antibodies
    James W Larrick; Fiscal Year: 2012
    ..proteomic and gene profiling methods, our collaborators have identified unique sets of tumor-specific cell surface antigens that are not usually co-expressed on non-malignant cells...
  56. Novel HBV Therapeutic with Potential for Treatment of Drug-Resistant Infection
    Andrea Cuconati; Fiscal Year: 2013
    ..Concurrent with the above aims, we will 7) attempt to identify the precise molecular target of the TTPs through affinity studies. At the end of Phase 2, a TTP compound will be ready for IND filing and eventual clinical trials. ..
  57. The role of Variable Erythrocyte Surface Antigen (VESA1) proteins in Babesia bovi
    KERRY SUE SONDGEROTH; Fiscal Year: 2013
    ....
  58. CD20 DNA VACCINATION FOR B-CELL LYMPHOMA
    Maria Lia Palomba; Fiscal Year: 2010
    ..Furthermore, she proposes to explore the effect of CD20 immunization in the post-bone marrow transplant settings. Finally, the candidate proposes to carry out a phase I clinical trial of CD20 DNA vaccine in patients with lymphoma. ..
  59. Antibody-CpG conjugates for the treatment of B cell lymphoma
    John M Timmerman; Fiscal Year: 2013
    ..Aim 5. Explore antibody-CpG conjugates targeting alternative B cell lymphoma surface antigens such as CD19, that internalize upon antibody binding, further broadening the applicability of this approach...
  60. Vaccine Prevention of Group A Streptococcal Infections
    James B Dale; Fiscal Year: 2013
    ..In our efforts to identify surface antigens of GAS that could be combined with M proteins to improve vaccine efficacy, we discovered that M- related ..
  61. MOLECULAR PATHOGENESIS OF BLASTOMYCOSIS
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..Our work will resolve the molecular and structural bases of BIastomcyes virulence and define how BAD1 is regulated and controlled coordinately with other yeast-phase genes, which is a key event in fungal pathogenesis. ..
  62. A New Theranostic System for PET Image Guided Radiotherapy of Cancer
    Johannes Czernin; Fiscal Year: 2013
    ..The ultimate objective of this proposal is the development of a novel theranostic system, to be used for highly specific cancer radiation therapy with the radiopharmaceutical 90Y-AABD. ..
  63. DRW HIV-Ab/HBsAg Duplex Rapid Test submission for FDA-PMA approval
    Helen Lee; Fiscal Year: 2009
    ..This is especially true in blood banks processing less than10,000 donations/year located in regions of high prevalence for the HIV and HBV viral markers. Confidential information: patent application in process ..
  64. NATURAL IMMUNITY TO ENTAMOEBA HISTOLYTICA
    JONATHAN RAVDIN; Fiscal Year: 1999
    ..This proposal will address an incredibly important issues in amebiasis research and have a major impact on vaccine development and clinical practice in the field. ..
  65. UROTHELIAL CELL ACTIVATION IN INTERSTITIAL CYSTITIS
    Monica Liebert; Fiscal Year: 1993
    ..To characterize the cytokine production and expression of an activated phenotype (induced expression of cell surface antigens such as HLA-DR or intercellular adhesion molecule-1 [ICAM-1]) by urothelial cells in vitro...
  66. VIP AND EGF RECEPTORS IN NON-SMALL CELL LUNG CANCER
    Terry Moody; Fiscal Year: 1991
    ..These studies will further define the cell surface receptors present on lung cancer cells and aid in determining if these receptors can be utilized to develop novel therapeutic approaches for the treatment of lung cancer...
  67. NASAL COLONIZATION BY S AUREUS--MECHANISMS AND IMMUNITY
    Jean Lee; Fiscal Year: 2003
    ..goal of this study is to utilize this animal model to determine whether the expression of staphylococcal surface antigens influences the establishment of colonization...
  68. SERTOLI CELL-GERM CELL SURFACE MEMBRANE INTERACTIONS
    ROBERT DEPHILIP; Fiscal Year: 1991
    ..corresponding to these antibodies; (3) an examination of the temporal and spatial expression of Sertoli cell surface antigens in developing and in mature, cycling seminiferous tubules; and (4) the identification of Sertoli cell surface ..
  69. MECHANISMS OF IGE SYNTHESIS BY B CELLS
    Raif Geha; Fiscal Year: 2007
    ..and c). the MAP kinases p38 and JNK. The results of the proposed studies should have an important impact on the understanding and treatment of allergic and immunologic diseases. ..