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| surface antigensSummarySummary: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated. Top Publications
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Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulationAmanda L Blasius
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 177:3260-5. 2006..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC...
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activationG J Freeman
Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 192:1027-34. 2000..PD-L1 expression on nonlymphoid tissues and its potential interaction with PD-1 may subsequently determine the extent of immune responses at sites of inflammation...- Identification of a factor that links apoptotic cells to phagocytesRikinari Hanayama
Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
Nature 417:182-7. 2002..These results indicate that MFG-E8 secreted from activated macrophages binds to apoptotic cells, and brings them to phagocytes for engulfment... - MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4R Shimazu
Department of Immunology, Saga Medical School, Saga, Japan
J Exp Med 189:1777-82. 1999..MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms... - Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptorH Nishimura
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
Immunity 11:141-51. 1999..Collectively, it is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses... - PD-L2 is a second ligand for PD-1 and inhibits T cell activationY Latchman
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 2:261-8. 2001..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses... - Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasionHaidong Dong
Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
Nat Med 8:793-800. 2002..These findings have implications for the design of T cell-based cancer immunotherapy... - Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient miceH Nishimura
Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo, Kyoto, 606 8501, Japan
Science 291:319-22. 2001..These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases... - Identification of a novel population of Langerin+ dendritic cellsLaura S Bursch
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
J Exp Med 204:3147-56. 2007..This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems... - Blood-derived dermal langerin+ dendritic cells survey the skin in the steady stateFlorent Ginhoux
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Exp Med 204:3133-46. 2007..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies... - Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockadeYoshiko Iwai
Department of Medical Chemistry, Graduate School of Medicine, Japan Science and Technology Corporation, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 99:12293-7. 2002.... - NKT cells: what's in a name?Dale I Godfrey
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Nat Rev Immunol 4:231-7. 2004 - Phosphorylation of HuR by Chk2 regulates SIRT1 expressionKotb Abdelmohsen
Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Mol Cell 25:543-57. 2007..Our findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes... - RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alphaStefanie Galban
LCMB, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
Mol Cell Biol 28:93-107. 2008..Conversely, HIF-1alpha expression and translation in response to CoCl(2) were markedly elevated after HuR overexpression. We propose that HuR and PTB jointly upregulate HIF-1alpha translation in response to CoCl(2)... - PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosineT Okazaki
Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan
Proc Natl Acad Sci U S A 98:13866-71. 2001..These results show that PD-1 can inhibit BCR signaling by recruiting SHP-2 to its phosphotyrosine and dephosphorylating key signal transducers of BCR signaling... - PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2LauraL Carter
Wyeth Genetics Institute, Cambridge, MA 02140, USA
Eur J Immunol 32:634-43. 2002..However, CD8(+) T cells may be more sensitive to modulation by the PD-1:PD-L pathway because of their intrinsic inability to produce significant levels of IL-2... - Essential role of MD-2 in LPS responsiveness and TLR4 distributionYoshinori Nagai
Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Nat Immunol 3:667-72. 2002..Thus, MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4... - Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell deathY Ishida
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
EMBO J 11:3887-95. 1992..These results suggest that activation of the PD-1 gene may be involved in the classical type of programmed cell death... - Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variantsP C Bull
Kenya Medical Research Institute CGMRC, Kilifi Unit, Kilifi, Kenya
Infect Immun 67:733-9. 1999..These results support the idea that preexisting anti-PfEMP1 antibodies can select the variants that are expressed during a new infection and may suggest the existence of a dominant subset of PfEMP1 variants... - HuR regulates p21 mRNA stabilization by UV lightW Wang
Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Mol Cell Biol 20:760-9. 2000..Our findings indicate that HuR plays a major role in regulating stress-induced p21 expression by enhancing p21 mRNA stability and that these effects are coupled to HuR's elevated presence in the cytoplasm... - Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitisAlan D Salama
Laboratory of Immunogenetics and Transplantation, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 198:71-8. 2003..Interestingly, PD-L2 but not PD-L1 blockade in WT animals also resulted in disease augmentation. Our data are the first demonstration that the PD-1 pathway plays a critical role in regulating EAE... - Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adultsSalenna R Elliott
Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
Am J Trop Med Hyg 76:860-4. 2007Antibodies to variant surface antigens (VSA) including Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) have been associated with protective antimalarial immunity that appears to be variant-specific... - B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cellsS Y Tseng
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Exp Med 193:839-46. 2001..These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses... 
Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesisR M Maizels
Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh, UK
Parasitology 136:1549-64. 2009..The review concludes with a forward look to where we may make future advances towards the final eradication of helminth diseases...- Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNAAnke Doller
Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
Mol Cell Biol 28:2608-25. 2008..Posttranslational modification of HuR by PKCdelta represents an important novel mode of HuR activation implied in renal COX-2 regulation... - Surface antigens of human embryonic stem cells: changes upon differentiation in cultureJonathan S Draper
Department of Biomedical Science, University of Sheffield, UK
J Anat 200:249-58. 2002..The surface antigens characteristically expressed by hES cells were down-regulated following induction of differentiation and .. - Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functionsKeisuke Nagao
Dermatology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:3312-7. 2009..The presence of at least 3 functionally distinct skin DC subsets may have particular relevance for vaccines that are administered epicutaneously... - Restoring function in exhausted CD8 T cells during chronic viral infectionDaniel L Barber
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Nature 439:682-7. 2006..These studies identify a specific mechanism of T-cell exhaustion and define a potentially effective immunological strategy for the treatment of chronic viral infections... - Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2Anke Doller
Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
Mol Biol Cell 18:2137-48. 2007..Regulation of HuR via PKC alpha-dependent phosphorylation emphasizes the importance of posttranslational modification for stimulus-dependent HuR shuttling... - Expression of programmed death 1 ligands by murine T cells and APCTomohide Yamazaki
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
J Immunol 169:5538-45. 2002..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation... - HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasitesJessica Keen
Faculty of Medicine, University of Toronto, Toronto, Canada
PLoS Med 4:e181. 2007..Protection against PAM is associated with the production of IgG specific for variant surface antigens (VSA-PAM) expressed by chondroitin sulfate A (CSA)-adhering parasitized erythrocytes (PEs)... - Blood group terminology 2004: from the International Society of Blood Transfusion committee on terminology for red cell surface antigensG L Daniels
Bristol Institute for Transfusion Sciences, Bristol, UK
Vox Sang 87:304-16. 2004 - Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparumPaul R Gilson
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Mol Cell Proteomics 5:1286-99. 2006..Together this work identified 11 and predicted a further 19 GPI-anchored proteins in P. falciparum... - Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasionUte Woehlbier
Zentrum für Molekulare Biologie ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
Malar J 9:77. 2010..Components of the MSP-1/6/7 complex and AMA-1 are presently under development as malaria vaccines... - Long-term culture of human embryonic stem cells in feeder-free conditionsElen S Rosler
Geron Corporation, Menlo Park, California, USA
Dev Dyn 229:259-74. 2004.... - Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responsesSpencer C Liang
Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA
Eur J Immunol 33:2706-16. 2003..PD-L2, but not PD-L1, expression was dramatically reduced in p50(-/-)p65(+/-) DC. Thus, PD-L1 and PD-L2 exhibit distinct expression patterns and are differentially regulated on the transcriptional level... - The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine developmentLars Hviid
Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Hum Vaccin 6:84-9. 2010There is substantial immuno-epidemiological evidence that the parasite-encoded, so-called variant surface antigens (VSAs), such as PfEMP1 on the surface of infected erythrocytes (IEs) are important-in some cases probably decisive .. - Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgEH R Katz
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 93:10809-14. 1996..Our findings establish a novel counterregulatory transmembrane pathway by which mast cell activation can be inhibited... - Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cellsChristine Hostetter
Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey 08106, USA
Cancer Biol Ther 7:1496-506. 2008..Our data describe a novel mechanism for the development of tamoxifen resistance and is the first study to identify an RNA binding protein as a key mediator of resistance in breast cancer cells... - The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cellsLionel Franz Poulin
Centre d immunologie de Marseille Luminy, Universite de la Mediterrannee, Case 906, 13288 Marseille Cedex 9, France
J Exp Med 204:3119-31. 2007..Our results stress that the langerin(+) DC network is more complex than originally thought and have implications for the development of transcutaneous vaccines and the improvement of humanized mouse models... - Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complexK M Misura
Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
Nature 404:355-62. 2000..The structure also indicates mechanisms that might couple the action of upstream effector proteins to conformational changes in syntaxin 1a and nSec1 that lead to core complex formation and membrane fusion... - Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritisNicoletta Fiore
Renal Unit, Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Piazza G Cesare 11, 70124 Bari, Italy
Mol Immunol 45:259-65. 2008..These results show for the first time that three DCs subsets, decreased at circulating levels, are recruited within the kidney, indicating that DCs might play a pathogenic role in SLE patients with nephritis... - Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescenceKotb Abdelmohsen
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21228, USA
Biol Chem 389:243-55. 2008.... - Posttranscriptional orchestration of an anti-apoptotic program by HuRKotb Abdelmohsen
Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
Cell Cycle 6:1288-92. 2007.... - Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotypeK Mazan-Mamczarz
Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
Oncogene 27:6151-63. 2008.... - Identification of a target RNA motif for RNA-binding protein HuRIsabel Lopez de Silanes
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 101:2987-92. 2004..This study describes an HuR target RNA motif and presents a general strategy for identifying target motifs for RNA-binding proteins... - Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAsAshish Lal
Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, MD 21224, USA
EMBO J 23:3092-102. 2004.... - Sperm protein 17 is a novel cancer-testis antigen in multiple myelomaS H Lim
Center for Immunology and Microbial Disease and the Department of Medicine, Albany Medical College, Albany, NY 12208, USA
Blood 97:1508-10. 2001..Sp17 is therefore a novel member of the CT antigen family and should be an ideal target for immunotherapy of multiple myeloma... - Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine productionJulia A Brown
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Immunol 170:1257-66. 2003..PD-L1 is also highly expressed on most carcinomas but minimally expressed on adjacent normal tissue suggesting a role in attenuating antitumor immune responses... - Lactadherin promotes VEGF-dependent neovascularizationJean Sebastien Silvestre
Cardiovascular Research Center INSERM U689 Lariboisière, Universite Paris 7, Hopital Lariboisiere, 41 Bvd de la Chapelle, 75475 Paris Cedex 10, France
Nat Med 11:499-506. 2005..These results show a crucial role for lactadherin in VEGF-dependent neovascularization and identify lactadherin as an important target for the modulation of neovascularization... - Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cellsMiriam Merad
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Nat Rev Immunol 8:935-47. 2008..In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity... - Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cellsAdrien Kissenpfennig
Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
Immunity 22:643-54. 2005..By using a similar knockin strategy involving a diphtheria toxin receptor (DTR) fused to EGFP, we demonstrated that LCs were dispensable for triggering hapten-specific T cell effectors through skin immunization... - Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrinA M Mercurio
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Semin Cancer Biol 11:129-41. 2001..Such studies have revealed novel insights into the mechanism of carcinoma invasion that involve both the dynamics of cell migration and signaling pathways that regulate this migration... - Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-associated malariaAnthony Jaworowski
Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Clin Vaccine Immunol 16:312-9. 2009Human immunodeficiency virus type 1 (HIV-1) coinfection decreases antibodies to variant surface antigens implicated in pregnancy-associated malaria (VSA-PAM) caused by Plasmodium falciparum... - Identification and mechanistic characterization of low-molecular-weight inhibitors for HuRNicole Claudia Meisner
Novartis Institutes for BioMedical Research, Discovery Technologies, Brunnerstr 59, A 1235 Vienna, Austria
Nat Chem Biol 3:508-15. 2007..MS-444, dehydromutactin and okicenone may become valuable tools for studying HuR function. An assessment of HuR inhibition as a central node in malignant processes might open up new conceptual routes toward combatting cancer... - Highly polymorphic family of glycosylphosphatidylinositol-anchored surface antigens with evidence of developmental regulation in Toxoplasma gondiiAngela M Pollard
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
Infect Immun 76:103-10. 2008..T. gondii has a superfamily of glycosylphosphatidylinositol (GPI)-anchored surface antigens, termed the surface antigen (SAG) and SAG-related surface antigens, that are developmentally regulated during .. - Novel antimicrobial peptide of human epididymal duct originHans Henning von Horsten
IHF Institute for Hormone and Fertility Research at the University of Hamburg, D 22529 Hamburg, Germany
Biol Reprod 67:804-13. 2002.... - Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptorDavid B Rosen
Department of Microbiology and Immunology, The Cancer Research Institute, and Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA
J Immunol 175:7796-9. 2005..Moreover, LLT1 on target cells can inhibit NK cytotoxicity via interactions with NKR-P1A... - Prognostic role of HuR in hereditary breast cancerMira Heinonen
Department of Pathology HUSLAB and Haartman Institute, Helsinki University Central Hospital, Finland
Clin Cancer Res 13:6959-63. 2007..Elevated cytoplasmic expression of HuR protein has been linked to carcinogenesis and is associated with reduced survival in breast, ovarian, and gastric adenocarcinomas... - Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleenJuliana Idoyaga
Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Proc Natl Acad Sci U S A 106:1524-9. 2009..Therefore, anti-Langerin antibodies localize a majority of CD8(+) DCs to non-T cell regions of mouse spleen, where they are distinct from adjacent macrophages... - Antibacterial properties of the sperm-binding proteins and peptides of human epididymis 2 (HE2) family; salt sensitivity, structural dependence and their interaction with outer and cytoplasmic membranes of Escherichia coliSuresh Yenugu
Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina, Chapel Hill 27599-7500, USA
Biochem J 372:473-83. 2003..coli membranes. A much longer exposure time was required for human beta-defensin-1-mediated permeabilization of membranes, suggesting a possible difference in mode of action compared with the HE2 antibacterial peptides... - Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigensChun Hong Qiu
RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
J Immunol 182:4127-36. 2009..Transient ablation of this DC subset by cytochrome c injection resulted in a failure of tolerance induction to cell-associated Ags, indicating that this DC subset is essential for tolerance induction by apoptotic cell clearance... - Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homingNobuyoshi Hiraoka
Glycobiology Program, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 279:3058-67. 2004.... - Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigensWilliam R Heath
Department of Immunology and The Cooperative Research Center for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Immunol Rev 199:9-26. 2004..In this review, we examine the molecular basis for cross-presentation, discuss the role of DC subsets, and examine the contribution of this process to immunity, with some emphasis on DNA vaccination... - Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cellsLan Xiao
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 18:4579-90. 2007..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis... - Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolutionR B Sutton
The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Nature 395:347-53. 1998..These characteristics may be important for membrane fusion and for the binding of regulatory factors affecting neurotransmission... - Activation-induced expression of human programmed death-1 gene in T-lymphocytesR Vibhakar
Department of Pathology, New York Medical College, Elmsford 10523, USA
Exp Cell Res 232:25-8. 1997..These data suggest a role for hPD-1 during activation and differentiation of T-lymphocytes... - Phosphorylated HuR shuttles in cyclesHyeon Ho Kim
Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
Cell Cycle 7:3124-6. 2008..In this manner, HuR helps to schedule gene expression programs in a cell cycle-dependent manner... - Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequencesElizabeth J Fialcowitz-White
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 282:20948-59. 2007..Together, the results define distinct roles for the HuR hinge and RRM3 domains in formation of cooperative HuR.ARE complexes in solution... - The quantity and quality of African children's IgG responses to merozoite surface antigens reflect protection against Plasmodium falciparum malariaDavid Courtin
Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 4:e7590. 2009..Evaluating such responses in longitudinal sero-epidemiological field studies, allied to increasing knowledge of the immunological mechanisms associated with anti-malarial protection, will help in the development of malaria vaccines... - A new Borrelia species defined by multilocus sequence analysis of housekeeping genesGabriele Margos
Department of Biology and Biochemistry, University of Bath, 3 South, Claverton Down, Bath BA2 7AY, United Kingdom
Appl Environ Microbiol 75:5410-6. 2009..We suggest that OspA serotype 4 strains be raised to species status and named Borrelia bavariensis sp. nov. The rooted phylogenetic trees provide novel insights into the evolutionary history of LB spirochetes... - Lymphocyte migration to inflamed lacrimal glands is mediated by vascular cell adhesion molecule-1/alpha(4)beta(1) integrin, peripheral node addressin/l-selectin, and lymphocyte function-associated antigen-1 adhesion pathwaysA Mikulowska Mennis
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
Am J Pathol 159:671-81. 2001..These adhesion molecules offer potential therapeutic targets to block the development of lacrimal gland inflammation and destruction... - Liver CD4-CD8- NK1.1+ TCR alpha beta intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against the parasite liver stage in vitroS Pied
Institut National de la Santé et de la Recherche Médicale U313, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, CHU Pitie Salpetriere, Paris, France
J Immunol 164:1463-9. 2000..These results suggest that up-regulation of CD4-CD8- NK1.1+ alpha beta T cells and down-regulation of CD4+ NK1.1+ TCR alpha beta int cells may contribute to the early immune response induced by the Plasmodium during the prime infection... - A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venulesKenji Uchimura
Department of Anatomy, Program in Immunology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
Nat Immunol 6:1105-13. 2005..Our results establish an essential function for the sulfotransferases in L-selectin ligand synthesis and may have relevance for therapy of inflammatory diseases... - Identification of CD4+ and CD8+ T cell epitopes of woodchuck hepatitis virus core and surface antigens in BALB/c miceL Ochoa-Callejero
Laboratory of Gene Therapy of Viral Hepatitis, Division of Gene Therapy and Hepatology, Center for Applied Medical Research CIMA, Pamplona, Navarra, Spain
Vaccine 28:5323-31. 2010..novel H-2 d-restricted CD8+ epitopes within the WHV core (peptides C#12-21, C#18-32, C#19-27, C#61-69) and surface antigens (peptides preS2#10-18, preS2#27-35, S#76-84, S#133-140 and S#257-265), respectively... - Sarcocystis neurona merozoites express a family of immunogenic surface antigens that are orthologues of the Toxoplasma gondii surface antigens (SAGs) and SAG-related sequencesDaniel K Howe
Department of Veterinary Science, 108 Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546 0099, USA
Infect Immun 73:1023-33. 2005..sequence tag (EST) database revealed four paralogous proteins that exhibit clear homology to the family of surface antigens (SAGs) and SAG-related sequences of Toxoplasma gondii. The primary peptide sequences of the S... - Microanatomical localization of PD-1 in human tonsilsYoshiko Iwai
Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
Immunol Lett 83:215-20. 2002..These results suggest that PD-1 may play an important role in GC reaction... - Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuRTomoko Kawai
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program NIH, Box 12, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Mol Cell Biol 26:3295-307. 2006.... - Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritisAllen C Steere
Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
Arthritis Rheum 48:534-40. 2003..To assess the binding of outer surface protein A (OspA) and human lymphocyte function-associated antigen 1 (hLFA-1) peptides to 5 major histocompatibility complex (MHC) molecules... - gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infectionIleana C Cuevas
, , , , , Provincia de Buenos Aires, Argentina
Infect Immun 71:5739-49. 2003..Since antibodies against Tcgp63-I partially blocked infection of Vero cells by trypomastigotes, a possible role for this group in infection is suggested... - HuR in the mammalian genotoxic response: post-transcriptional multitaskingMyriam Gorospe
Laboratory of Cellular and Molecular Biology, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
Cell Cycle 2:412-4. 2003 - Expression of cell-surface antigens in acute promyelocytic leukaemiaElisabeth Paietta
New York Medical College, Valhalla, NY, USA
Best Pract Res Clin Haematol 16:369-85. 2003..Despite some significant antigenic differences (e.g. in CD34 expression), this surrogate marker profile for t(15;17) APL applies to both the M3 and the M3v FAB phenotypes and to all three isoforms of the PML/RARalpha transcript... - Determination of members of a Borrelia afzelii-related group isolated from Ixodes nipponensis in Korea as Borrelia valaisianaT Masuzawa
Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka, Japan
Int J Syst Bacteriol 49:1409-15. 1999..valaisiana and that OspA of this species is divergent, as is that of Borrelia garinii. This led to the speculation that B. valaisiana strains are adapted to the vector ticks found in each locality... - A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responsesM A Exley
Cancer Biology Program, Hematology Oncology, Beth Israel Deaconess Medical Center, Bone Marrow Transplant Program, Harvard Skin Disease Research Center, Harvard Medical School, Boston, MA 02115, USA
J Immunol 167:5531-4. 2001..Distinct CD1d-reactive T cell populations have the potential to suppress graft-vs-host disease and stimulate antitumor responses... - BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral bloodA Dzionek
Miltenyi Biotec GmbH, Bergisch Gladbach, Germany AmCell Corporation, Sunnyvale, CA 94089, USA
J Immunol 165:6037-46. 2000..The three presumably novel Ags serve as specific markers for the respective subpopulations of blood dendritic cells in fresh blood and will be of great value for their further analysis and to evaluate their therapeutic potential... - Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 sY Bulut
Division of Pediatric Critical Care, Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
J Immunol 167:987-94. 2001..Our data also suggest that Tollip may be an important constituent of both the TLR2 and TLR4 signaling pathways... - Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferiH Kumar
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA
J Immunol 165:4797-801. 2000..These results show that CD1d deficiency impairs host resistance to a spirochete pathogen, and are the first example of a mutation that imparts Bb-resistant mice with the Ab and disease profile of a susceptible mouse strain... - Sequential expression of surface antigens and transcription factor NFkappaB by hippocampal cells in excitotoxicity and experimental epilepsyM Lerner-Natoli
CNRS UPR 9023, Laboratoire de Medecine Experimentale, Institute de Biologie, Montpellier, France
Epilepsy Res 41:141-54. 2000..Further clarification of the toxic or protective consequences of delayed inflammatory responses may be interesting in therapy of epilepsy... - The B7-CD28 superfamilyArlene H Sharpe
Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Rev Immunol 2:116-26. 2002..Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential... - Breast carcinoma cells promote the differentiation of CD34+ progenitors towards 2 different subpopulations of dendritic cells with CD1a(high)CD86(-)Langerin- and CD1a(+)CD86(+)Langerin+ phenotypesMarie Cécile Thomachot
Equipe Cytokines et Cancers, INSERM U 590, Centre Léon B, Lyon, France
Int J Cancer 110:710-20. 2004..The infiltration of BCC by these altered DC may contribute to the impaired immune response against the tumor... - Toll-like receptor 4 mediates the antitumor host response induced by a 55-kilodalton protein isolated from Aeginetia indica L., a parasitic plantMasato Okamoto
Second Department of Oral and Maxillofacial Surgery, The University of Tokushima School of Dentistry, 3 18 15 Kuramoto cho, Tokushima 7708504, Japan
Clin Diagn Lab Immunol 11:483-95. 2004..Finally, the antitumor effect of AILb-A was also impaired in TLR4-deficient and TLR4-mutated mice. These findings suggest that TLR4 mediates antitumor immunity induced by the plant-derived protein AILb-A... - Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS responsesStefan Dunzendorfer
Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA
FASEB J 18:1117-9. 2004..Results further suggest that LBP levels, which vary as LBP is an acute phase reactant, could be relevant to initiating inflammatory responses in the vasculature in response to chronic or recurring low LPS... - Distribution and subcellular localization of a lysosome-associated protein in human genital organsG Aumuller
Department of Anatomy and Cell Biology, Philipps Universitat Marburg, Robert Koch Strasse 6, D 35033 Marburg an der Lahn, Germany
Cell Tissue Res 287:335-42. 1997..The findings indicate that in the human prostate most of the membrane-bound lamp 2 is released from the secretory cells, presumably in an apocrine fashion... - p46, a novel natural killer cell-specific surface molecule that mediates cell activationS Sivori
Istituto di Istologia ed Embriologia Generale, Universita di Genova, Genova, Italy
J Exp Med 186:1129-36. 1997..Both the unique cellular distribution and functional capability of p46 molecules suggest a possible role in the mechanisms of non-major histocompatibility complex-restricted cytolysis mediated by human NK cells... - Chemokine receptor expression on mucosal dendritic cells from the endocervix of healthy womenManyu Prakash
Department of Immunology, Faculty of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
J Infect Dis 190:246-50. 2004..CCR5 and CXCR4 were detected on CD1a-positive and -negative cervical DCs. These findings suggest that DCs in the genital tract are potential targets for macrophage-tropic and lymphotropic strains of HIV... - A novel adjuvant-allergen complex, CBP-rFel d 1, induces up-regulation of CD86 expression and enhances cytokine release by human dendritic cells in vitroTheresa N Andersson
Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden
Immunology 113:253-9. 2004..Altogether, our results indicate that the use of CBPs as an allergen carrier and adjuvant is a promising candidate for the improvement of allergen-specific immunotherapy... - Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivoJuliana Idoyaga
Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
J Immunol 180:3647-50. 2008..Peptide MHC I and II complexes persist for days. Dose response studies indicate only modest differences between Langerin and DEC receptors in these functions. Thus, Langerin effectively mediates Ag presentation... - Expression of Thy-1 on human hematopoietic progenitor cellsW Craig
Terry Fox Laboratory, British Columbia Cancer Agency, Departments of Medicine, Pathology, and Medical Genetics, University of British Columbia, Vancouver, Canada
J Exp Med 177:1331-42. 1993..Taken together our results indicate that Thy-1-specific antibody 5E10 is an attractive tool for further studies on the biology and purification of human stem cells... - [cDNA macroarray analysis of genes responsible for cartilage formation]Hideaki Kamochi
Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University
Kokubyo Gakkai Zasshi 71:27-37. 2004..A similar process is somewhat observed in osteoarthritis. Therefore, activation of these genes might be closely related to the progression of osteoarthritis and would be a useful marker for it... - NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protectionAna Paula Junqueira-Kipnis
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
J Immunol 171:6039-45. 2003.... - Identification of the S-Endo 1 endothelial-associated antigenN Bardin
Laboratoire d Hematologie, Faculte de Pharmacie, Marseille, France
Biochem Biophys Res Commun 218:210-6. 1996..The difference in antibodies immunoreactivity and antigen molecular weight heterogeneity observed between various cell types strongly suggested S-Endo 1 antigen isoforms expression...
Research Grants
- SURFACE ANTIGENS OF ORAL BACTEROIDES SPECIESAnn Progulske Fox; Fiscal Year: 1993..gingivalis HAs, determination of functional/virulence properties of the HAs and information concerning the receptor target molecules on the erythrocyte membrane...
- Nanopore Biosensor for Kinetics of Reparative Antibodies on Plasma MembranesSang Hyun Oh; Fiscal Year: 2010..in moving these reparative IgMs to clinical trial is to understand the kinetics of binding to the cell-surface antigens. Our hypothesis and preliminary data suggests that the mAbs do not bind to a single membrane molecule, but to ..
- Variant surface antigens and immunity to malariaJames Burns; Fiscal Year: 2007..We will focus on plasmodial proteins and variant surface antigens expressed on the reticulocyte surface, on their role in mediating adherence of pRBCs to vascular endothelium ..
- Variant surface antigens and immunity to malariaJAMES MATTHEW BURNS; Fiscal Year: 2010..We will focus on plasmodial proteins and variant surface antigens expressed on the reticulocyte surface, on their role in mediating adherence of pRBCs to vascular endothelium ..
- NASAL COLONIZATION BY S AUREUS--MECHANISMS AND IMMUNITYJean Lee; Fiscal Year: 2003..goal of this study is to utilize this animal model to determine whether the expression of staphylococcal surface antigens influences the establishment of colonization...
- CANDIDA ALBICANS SURFACE ANTIGENSJim Cutler; Fiscal Year: 1993..Finally, we developed the techniques and tools to focus on this important host/C. albicans interaction and should be able to fulfill our intended goals...
- ISLET CELL MEMBRANE ANTIBODIES IN DIABETESAke Lernmark; Fiscal Year: 1992..Our hypothesis is that beta-cell specific surface antigens guide the immune-associated beta-cell attack...
- CANDIDA ALBICANS SURFACE ANTIGENSJim Cutler; Fiscal Year: 1991The long term objectives are to characterize the surface antigens expressed by Candida albicans during in vitro and in vivo development, determine if monoclonal antibodies raised against these antigens may be used to biotype strains of C...
- REGULATION OF HEPATITIS B VIRUS TRANSCRIPTIONAlan McLachlan; Fiscal Year: 1993..The cloning of the genes for these factors will permit the analysis of the mechanism by which these factors interact with their recognition sequences and influence the transcriptional activity of the HBV promoters...
- ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSIONGyongyi Szabo; Fiscal Year: 2003..affects the immune system by altering monocyte accessory capacity, cytokine production, and expression of surface antigens/receptors involved in monocyte-T cell interactions...
- MECHANISMS OF IGE SYNTHESIS BY B CELLSRaif Geha; Fiscal Year: 2007..and c). the MAP kinases p38 and JNK. The results of the proposed studies should have an important impact on the understanding and treatment of allergic and immunologic diseases. ..