epitopes

Summary

Summary: Sites on an antigen that interact with specific antibodies.

Top Publications

  1. pmc Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    Laura M Walker
    Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 326:285-9. 2009
  2. pmc Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
    Xueling Wu
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 329:856-61. 2010
  3. pmc A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield
    Robert Pejchal
    Department of Molecular Biology, Skaggs Institute for Chemical Biology and International AIDS Vaccine Initiative IAVI Neutralizing Antibody Center, nhe Scripps Research Institute, La Jolla, CA 92037, USA
    Science 334:1097-103. 2011
  4. ncbi Antibody neutralization and escape by HIV-1
    Xiping Wei
    Howard Hughes Medical Institute, University of Alabama at Birmingham, 720 South 20th Street, Kaul 816, Birmingham, Alabama 35294 0024, USA
    Nature 422:307-12. 2003
  5. pmc Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
    Xueling Wu
    Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    Science 333:1593-602. 2011
  6. pmc The immune epitope database 2.0
    Randi Vita
    La Jolla Institute for Allergy and Immunology, Center for Infectious Disease, Allergy and Asthma Research, 9420 Athena Circle, La Jolla, CA 92037, USA
    Nucleic Acids Res 38:D854-62. 2010
  7. pmc Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
    Tongqing Zhou
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Science 329:811-7. 2010
  8. pmc Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus
    Rui Xu
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 328:357-60. 2010
  9. pmc Antibody recognition of a highly conserved influenza virus epitope
    Damian C Ekiert
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 324:246-51. 2009
  10. doi The role of antibodies in HIV vaccines
    John R Mascola
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 28:413-44. 2010

Research Grants

  1. Brucella epitope recognition by CD8+ T cells
    JEROME SCOTT HARMS; Fiscal Year: 2010
  2. Brucella epitope recognition by CD8+ T cells
    Gary Splitter; Fiscal Year: 2009
  3. SPOTTED FEVER RICKETTSIAL ANTIGENS
    David Walker; Fiscal Year: 2003
  4. VARIABLE GENE USE AND PNEUMOCOCCAL IMMUNITY IN AIDS
    Liise Anne Pirofski; Fiscal Year: 2004
  5. CD8+ T cell specificity in mouse models of smallpox vaccination and challenge
    David Tscharke; Fiscal Year: 2007
  6. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
  7. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2010
  8. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
  9. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
  10. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2004

Detail Information

Publications278 found, 100 shown here

  1. pmc Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    Laura M Walker
    Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 326:285-9. 2009
    ..neutralizing antibodies (bNAbs), which develop over time in some HIV-1-infected individuals, define critical epitopes for HIV vaccine design...
  2. pmc Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
    Xueling Wu
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 329:856-61. 2010
    ..Exceptionally broad HIV-1 neutralization can be achieved with individual antibodies targeted to the functionally conserved CD4bs of glycoprotein 120, an important insight for future HIV-1 vaccine design...
  3. pmc A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield
    Robert Pejchal
    Department of Molecular Biology, Skaggs Institute for Chemical Biology and International AIDS Vaccine Initiative IAVI Neutralizing Antibody Center, nhe Scripps Research Institute, La Jolla, CA 92037, USA
    Science 334:1097-103. 2011
    ..Furthermore, our data suggest that the high neutralization potency of PGT 127 and 128 immunoglobulin Gs may be mediated by cross-linking Env trimers on the viral surface...
  4. ncbi Antibody neutralization and escape by HIV-1
    Xiping Wei
    Howard Hughes Medical Institute, University of Alabama at Birmingham, 720 South 20th Street, Kaul 816, Birmingham, Alabama 35294 0024, USA
    Nature 422:307-12. 2003
    ..contained mutations in the env gene that were unexpectedly sparse, did not map generally to known neutralization epitopes, and involved primarily changes in N-linked glycosylation...
  5. pmc Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
    Xueling Wu
    Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
    Science 333:1593-602. 2011
    ....
  6. pmc The immune epitope database 2.0
    Randi Vita
    La Jolla Institute for Allergy and Immunology, Center for Infectious Disease, Allergy and Asthma Research, 9420 Athena Circle, La Jolla, CA 92037, USA
    Nucleic Acids Res 38:D854-62. 2010
    The Immune Epitope Database (IEDB, www.iedb.org) provides a catalog of experimentally characterized B and T cell epitopes, as well as data on Major Histocompatibility Complex (MHC) binding and MHC ligand elution experiments...
  7. pmc Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
    Tongqing Zhou
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Science 329:811-7. 2010
    ..Partial receptor mimicry and extensive affinity maturation thus facilitate neutralization of HIV-1 by natural human antibodies...
  8. pmc Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus
    Rui Xu
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 328:357-60. 2010
    ..Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic...
  9. pmc Antibody recognition of a highly conserved influenza virus epitope
    Damian C Ekiert
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 324:246-51. 2009
    ..The CR6261 epitope identified here should accelerate the design and implementation of improved vaccines that can elicit CR6261-like antibodies, as well as antibody-based therapies for the treatment of influenza...
  10. doi The role of antibodies in HIV vaccines
    John R Mascola
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 28:413-44. 2010
    ..Thus, current vaccine design efforts have focused on a more detailed understanding of these broadly neutralizing antibodies and their epitopes to inform the design of improved vaccines.
  11. pmc The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
    Nilu Goonetilleke
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, England, UK
    J Exp Med 206:1253-72. 2009
    ..virus escape, these first T cell responses often rapidly waned, leaving or being succeeded by T cell responses to epitopes which escaped more slowly or were invariant...
  12. doi Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
    David Weismann
    Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
    Nature 478:76-81. 2011
    ..Our findings provide important mechanistic insights into innate immune responses to oxidative stress, which may be exploited in the prevention of and therapy for AMD and other chronic inflammatory diseases...
  13. pmc Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
    Davide Corti
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    PLoS ONE 5:e8805. 2010
    ....
  14. pmc Structural definition of a conserved neutralization epitope on HIV-1 gp120
    Tongqing Zhou
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 445:732-7. 2007
    ..A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1...
  15. pmc Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection
    D Noah Sather
    Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    J Virol 83:757-69. 2009
    ..broad cross-neutralizing antibody responses were identified that targeted the gp120 subunit, but their precise epitopes mapped outside the variable regions and the CD4-binding site...
  16. pmc A highly conserved neutralizing epitope on group 2 influenza A viruses
    Damian C Ekiert
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 333:843-50. 2011
    ..Thus, a cocktail of two antibodies may be sufficient to neutralize most influenza A subtypes and, hence, enable development of a universal flu vaccine and broad-spectrum antibody therapies...
  17. pmc Elicitation of structure-specific antibodies by epitope scaffolds
    Gilad Ofek
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:17880-7. 2010
    ..Epitope scaffolds thus provide a means to elicit antibodies that recognize a predetermined target shape and sequence, even if that shape is transient in nature, and a means by which to dissect factors influencing such elicitation...
  18. pmc Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity
    Yury I Miller
    Department of Medicine MC0682, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Circ Res 108:235-48. 2011
    ..they also produce reactive oxygen species, which damage lipids, proteins and DNA, generating "oxidation-specific" epitopes. In this review, we discuss the hypothesis that such common oxidation-specific epitopes are a major target of ..
  19. ncbi Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans
    Katia Koelle
    Department of Ecology and Evolutionary Biology, 2019 Kraus Natural Science Building, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109 1048, USA
    Science 314:1898-903. 2006
    ..It captures the observed boom-and-bust pattern of viral evolution, with periods of antigenic stasis during which genetic diversity grows, and with episodic contraction of this diversity during cluster transitions...
  20. pmc Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
    Hugo Mouquet
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nature 467:591-5. 2010
    ..Despite the low affinity of the polyreactive combining site, heteroligation demonstrably increases the apparent affinity of polyreactive antibodies to HIV...
  21. pmc Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120
    Lei Chen
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 326:1123-7. 2009
    ..This incompatibility, the consequence of slight differences in CD4BS recognition, renders HIV-1 resistant to all but the most accurately targeted antibodies...
  22. pmc Reverse vaccinology: developing vaccines in the era of genomics
    Alessandro Sette
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92130, USA
    Immunity 33:530-41. 2010
    ..targets in bacteria, parasites, and large viruses and revealed virtually all their CD4(+) and CD8(+) T cell epitopes. The genomic information was first used for the development of a vaccine against serogroup B meningococcus, and ..
  23. pmc Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection
    E S Gray
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, Johannesburg, South Africa
    J Virol 81:6187-96. 2007
    ..were detected in 4 of 14 individuals within a year of infection, while antibodies to CD4-induced (CD4i) epitopes developed to high titers in 12 participants, in most cases before the development of autologous neutralizing ..
  24. ncbi Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
    Barton F Haynes
    Duke University School of Medicine, Durham, NC 27710, USA
    Science 308:1906-8. 2005
    ..may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus...
  25. pmc Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans
    Meng Yun Chou
    Department of Medicine, UCSD, La Jolla, California 92093, USA
    J Clin Invest 119:1335-49. 2009
    ..Adaptive immune responses to various oxidation-specific epitopes play an important role in atherogenesis...
  26. pmc Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes
    Jason S McLellan
    Vaccine Research Center, NIAID NIH, 40 Convent Drive, Bldg 40, Rm 2613B, Bethesda, MD 20892, USA
    J Virol 85:7788-96. 2011
    ..The structure revealed that the 101F and motavizumab epitopes are present in the postfusion state and that their conformations are similar to those observed in the antibody-..
  27. pmc Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies
    Zhongyu Zhu
    National Cancer Institute, Frederick, Maryland 21702 1201, USA
    J Virol 85:11401-8. 2011
    ....
  28. doi Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody
    Joseph J B Cockburn
    Unité de Virologie Structurale, Departement de Virologie, Institut Pasteur, 75724 Paris Cedex 15, France
    Structure 20:303-14. 2012
    ..The structures also highlight the mechanism by which A-strand Mabs disrupt the architecture of the mature virion, inducing premature fusion loop exposure and concomitant particle inactivation...
  29. ncbi Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission
    Cynthia A Derdeyn
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 USA
    Science 303:2019-22. 2004
    ..Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host...
  30. ncbi Predicting the evolution of human influenza A
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Science 286:1921-5. 1999
    ..However, not all codons in these sites had predictive value. Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift...
  31. ncbi Identification of neutralizing linear epitopes from the VP1 capsid protein of Enterovirus 71 using synthetic peptides
    Damian Guang Wei Foo
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Virus Res 125:61-8. 2007
    ..Altogether, these data indicate that SP70 represents a promising candidate for an effective synthetic peptide-based vaccine against EV71...
  32. pmc Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation
    Rosa Catera
    Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:665-74. 2008
    ..Since apoptosis can make autoantigens accessible for recognition by antibodies, and also create neo-epitopes by chemical modifications occurring naturally during this process, we sought to determine if CLL mAbs recognize ..
  33. ncbi Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL
    Christoph J Binder
    Divisions of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0682 USA
    Nat Med 9:736-43. 2003
    During the progression of atherosclerosis, autoantibodies are induced to epitopes of oxidized low-density lipoprotein (oxLDL) and active immunization of hypercholesterolemic mice with oxLDL ameliorates atherogenesis...
  34. pmc Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development
    Zuzana Staneková
    Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic
    Virol J 7:351. 2010
    ..Combination of chosen conserved antigens inducing cross-protective antibody response with epitopes activating also cross-protective cytotoxic T-cells would offer an attractive strategy for improving protection ..
  35. pmc Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41
    M B Zwick
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:10892-905. 2001
    ..Despite the apparent linear nature of the epitopes of Z13 and 4E10, denaturation of recombinant envelope protein reduces the binding of these MAbs, suggesting some ..
  36. pmc Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein
    Ania M Owsianka
    Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 89:653-9. 2008
    ..We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein...
  37. pmc IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
    Christoph J Binder
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Clin Invest 114:427-37. 2004
    ..These epitopes are recognized by both adaptive T cell-dependent (TD) and innate T cell-independent type 2 (TI-2) immune ..
  38. pmc Naturally occurring antibodies in humans can neutralize a variety of influenza virus strains, including H3, H1, H2, and H5
    Nobuko Ohshima
    Division of Antibody Project, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    J Virol 85:11048-57. 2011
    ..The possible epitope recognized by these clones is discussed...
  39. pmc High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control
    Christoph T Berger
    AIDS Research Institute, Fundació irsiCaixa HIVACAT, Hospital Universitari Germans Trias i Pujol, Ctra del Canyet s n, 08916 Badalona, Barcelona, Catalonia, Spain
    J Virol 85:9334-45. 2011
    ..we measured the functional avidities of HIV-specific CTL responses targeting 20 different, optimally defined CTL epitopes restricted by 13 different HLA class I alleles in a cohort comprising 44 HIV controllers and 68 HIV ..
  40. pmc Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting
    Lynn Morris
    Duke Human Vaccine Institute and Departments of Medicine, Surgery and Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS ONE 6:e23532. 2011
    ..These data indicate that there are multiple immunogenic targets in the C-terminus of the MPER of HIV-1 gp41 envelope and suggests that gp41 neutralizing epitopes may interact with a restricted set of naive B cells during HIV-1 infection.
  41. pmc Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope
    Gilad Ofek
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Instiutes of Health, Bethesda, MD 20892, USA
    J Virol 78:10724-37. 2004
    ..Based on these structural and biochemical results, immunization strategies for eliciting 2F5- and 4E10-like broadly neutralizing anti-HIV-1 antibodies are proposed...
  42. doi Cross-presentation of epitopes on virus-like particles via the MHC I receptor recycling pathway
    Stephanie J Win
    Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Immunol Cell Biol 89:681-8. 2011
    ..Finally, we found that cross-presentation of VLPs in vivo was not confined to CD8α(+) DC subsets. These data define the cross-presentation pathway for RHDV VLPs and may lead to improved cancer immunotherapies...
  43. pmc Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization
    Mikyung Kim
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 18:1235-43. 2011
    ..These epitopes can be engrafted onto protein scaffolds to serve as immunogens with high structural fidelity...
  44. ncbi Prediction of continuous B-cell epitopes in an antigen using recurrent neural network
    Sudipto Saha
    Institute of Microbial Technology, Chandigarh, India
    Proteins 65:40-8. 2006
    B-cell epitopes play a vital role in the development of peptide vaccines, in diagnosis of diseases, and also for allergy research. Experimental methods used for characterizing epitopes are time consuming and demand large resources...
  45. pmc High-mannose glycan-dependent epitopes are frequently targeted in broad neutralizing antibody responses during human immunodeficiency virus type 1 infection
    Christy L Lavine
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 86:2153-64. 2012
    ..Clearly defining the nature of BNAb epitopes on HIV-1 envelope glycoproteins (Envs) targeted in vivo is critical for future directions of anti-HIV-1 vaccine ..
  46. doi Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers--are they the cause or the consequence of the disease?
    Morten Asser Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730, Denmark
    Clin Biochem 43:793-804. 2010
    ..of this review is to discuss the potential usefulness of novel advances in the class of biochemical markers, neo-epitopes. Neo-epitopes are post-translational modifications (PTMs) of proteins formed by processes such as protease ..
  47. ncbi Evolutionary and immunological implications of contemporary HIV-1 variation
    B Korber
    Division of Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 98545, USA
    Br Med Bull 58:19-42. 2001
    ..The impact of HIV-1 variation on host immune response is reviewed in this context...
  48. pmc Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes
    Wayne D Crill
    Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, P O Box 2087, Fort Collins, CO 80522, USA
    J Virol 78:13975-86. 2004
    ..An understanding of flavivirus E-glycoprotein cross-reactive epitopes is therefore critical for improving public health responses to these serious diseases...
  49. pmc Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009
    ....
  50. pmc Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes
    Dorothea Bankwitz
    Division of Experimental Virology, TWINCORE Center for Experimental and Clinical Infection Research, Feodor Lynen Strasse 7 9, 30625 Hannover, Germany
    J Virol 84:5751-63. 2010
    ..Moreover, they indicate that HVR1 obstructs the viral CD81 binding site and conserved neutralizing epitopes. These functions likely optimize virus replication, facilitate immune escape, and thus foster establishment and ..
  51. pmc Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls
    Frank C Arnett
    Division of Rheumatology, Department of Internal Medicine, The University of Texas Health Science Center at Houston UTHSC H, 6431 Fannin Street, MSB 5 270, Houston, TX 77030, USA
    Ann Rheum Dis 69:822-7. 2010
    ..human leucocyte antigen-class II (HLA-class II) (DRB1, DQB1, DQA1 and DPB1) alleles, haplotypes and shared epitopes associated with scleroderma (systemic sclerosis (SSc)) and its subphenotypes in a large multi-ethnic US cohort by ..
  52. pmc Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions
    S Moses Dennison
    Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Virol 83:10211-23. 2009
    ..virus type 1 (HIV-1) gp41 involves both the viral membrane and gp41 membrane proximal external region (MPER) epitopes. In this study, we have used several biophysical tools to examine the secondary structure, orientation, and depth ..
  53. pmc Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Nat Med 17:366-71. 2011
    ..whether the vaccine exerted selective T cell pressure on breakthrough viruses, we identified potential T cell epitopes in the founder sequences and compared them to epitopes in the vaccine...
  54. pmc Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions
    Erin M Scherer
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:1529-34. 2010
    ....
  55. ncbi A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions
    Anu Tuominen
    Department of Internal Medicine and Biocenter Oulu, University of Oulu, Finland
    Arterioscler Thromb Vasc Biol 26:2096-102. 2006
    ..To determine the immunogenicity and origins of oxCL in vivo, we cloned a natural antibody to oxCL...
  56. pmc Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors
    S Costagliola
    I R I B H N and Department of Medical Genetics, ULB, 808 Lennik Street, B 1070 Brussels, Belgium
    EMBO J 21:504-13. 2002
    ..Site-directed mutagenesis experiments indicate that the motif, which is conserved in all members of the glycoprotein hormone receptor family, seems to play a similar role in the LH/CG and FSH receptors...
  57. pmc SEPPA: a computational server for spatial epitope prediction of protein antigens
    Jing Sun
    Department of Biomedical Engineering, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
    Nucleic Acids Res 37:W612-6. 2009
    ..The web server can be accessed at http://lifecenter.sgst.cn/seppa/index.php. Batch query is supported...
  58. ncbi HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
    Peter D Kwong
    Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:678-82. 2002
    ..Because this solution is available for cell-surface receptors but not for most antibodies, conformational masking enables HIV-1 to maintain receptor binding and simultaneously to resist neutralization...
  59. pmc Humoral immune responses of dengue fever patients using epitope-specific serotype-2 virus-like particle antigens
    Wayne D Crill
    Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Service, Fort Collins, CO, USA
    PLoS ONE 4:e4991. 2009
    ..DENV-2 envelope (E) protein epitope-specific antigens and measure immunoglobulin responses to three distinct epitopes in DENV-2 infected human serum samples...
  60. pmc Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding
    Q J Sattentau
    Academic Department of Genito Urinary Medicine, University College and Middlesex School of Medicine, London, United Kingdom
    J Exp Med 174:407-15. 1991
    ..are coordinate with the dissociation of gp120/sCD4 complexes from gp41, and the increased exposure of gp41 epitopes. At 4 degrees C, gp120 dissociation from the cell surface does not occur, but increased exposure of both gp120/V3 ..
  61. pmc Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    Proc Natl Acad Sci U S A 107:18950-5. 2010
    ....
  62. pmc Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses
    Stephanie Gras
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:12599-604. 2010
    ..with the A(H1N1)-2009 virus, however, elicits CD8(+) T cells specific for the 2009-NP(418) and 1918-NP(418) epitopes. This analysis points to the potential importance of cross-reactive T-cell populations that cover the possible ..
  63. doi A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen
    N Barascuk
    Nordic Bioscience A S, Herlev, Denmark
    Clin Biochem 43:899-904. 2010
    ..Accumulation of extracellular matrix (ECM) components and increased matrix-metalloprotease (MMPs) activity are hallmarks of fibrosis. We developed an ELISA for quantification of MMP-9 derived collagen type III (CO3) degradation...
  64. pmc Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population
    Jason A Greenbaum
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20365-70. 2009
    ..we examined the molecular basis for pre-existing immunity against S-OIV, namely the recognition of viral immune epitopes by T cells or B cells/antibodies that have been previously primed by circulating influenza strains...
  65. pmc Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register
    Brian D Stadinski
    Integrated Department of Immunology, University of Colorado and National Jewish Health, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 107:10978-83. 2010
    ..Our findings suggest that the association of autoimmunity with particular MHCII alleles may be do to poorer, rather than more favorable, binding of the critical self-epitopes, allowing T-cell escape from thymic deletion.
  66. pmc Differential neutralization efficiency of hemagglutinin epitopes, antibody interference, and the design of influenza vaccines
    Wilfred Ndifon
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 106:8701-6. 2009
    ..gained from the model, together with genetic and structural data, we predict that amino acid mutations to epitopes C and E of the HA of influenza A/H3N2 viruses could lead on average to an increase in the neutralization of the ..
  67. ncbi A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
    U Gunthert
    Institut fur Genetik, Universitat Karlsruhe, Federal Republic of Germany
    Cell 65:13-24. 1991
    ..Overexpression of pMeta-1 in the nonmetastasizing BSp73AS cells suffices to establish full metastatic behavior...
  68. ncbi Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide
    Damian Guang Wei Foo
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, MD4A, 5 Science Drive 2, Singapore 117597, Singapore
    Microbes Infect 9:1299-306. 2007
    ..In conclusion, EV71-neutralizing antibodies elicited by the synthetic peptide SP70 were able to confer good in vivo passive protection against homologous and heterologous EV71 strains in suckling Balb/c mice...
  69. pmc Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41
    S Moses Dennison
    Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS ONE 6:e27824. 2011
    ..Nonetheless, the Env-liposome prime-boost immunization strategy induced antibodies that recognized a gp41 fusion intermediate protein and was successful in focusing the antibody response to the desired epitope...
  70. pmc Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins
    S Horkko
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0682
    J Clin Invest 103:117-28. 1999
    We recently cloned monoclonal IgM autoantibodies which bind to epitopes of oxidized low-density lipoprotein (OxLDL) from apoE-deficient mice (EO- autoantibodies)...
  71. pmc Simultaneous quantitation of antibodies to neutralizing epitopes on virus-like particles for human papillomavirus types 6, 11, 16, and 18 by a multiplexed luminex assay
    David Opalka
    Virus and Cell Biology, Merck Research Laboratories, Wayne, Pennsylvania 19087 8630, USA
    Clin Diagn Lab Immunol 10:108-15. 2003
    ..phycoerythrin-labeled detection monoclonal antibodies binding to conformationally sensitive, neutralizing epitopes on the respective virus-like particles...
  72. doi Conserved structural elements in the V3 crown of HIV-1 gp120
    Xunqing Jiang
    Department of Biochemistry, New York University School of Medicine, New York, New York, USA
    Nat Struct Mol Biol 17:955-61. 2010
    ..These conserved elements could serve as epitopes to be targeted by a vaccine against HIV-1...
  73. pmc Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies
    Ben Jiang Ma
    Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS Pathog 7:e1002200. 2011
    ..binding to gp140 Env may not always be due to lack of unmutated ancestor antibody reactivity with gp41 peptide epitopes, but rather, may be due to glycan interference of binding of unmutated ancestor antibodies of broad neutralizing ..
  74. pmc Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions
    Ruklanthi de Alwis
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:7439-44. 2012
    ..though infected individuals develop potent and long-lasting serotype-specific neutralizing antibodies (Abs), the epitopes engaged by human neutralizing Abs have not been identified...
  75. ncbi Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
    James W Huleatt
    VaxInnate Corporation, 300 George Street, New Haven, CT 06511, USA
    Vaccine 26:201-14. 2008
    ..These data demonstrate that the linkage of specific TLR ligand with influenza M2e yields a vaccine candidate that offers significant promise for widespread protection against multiple influenza A virus strains...
  76. pmc HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes
    Nicole A Doria-Rose
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:3393-7. 2012
    ..We analyzed the interaction of MAbs to two independent epitopes on the viral envelope glycoprotein...
  77. pmc A point mutation leading to hepatitis C virus escape from neutralization by a monoclonal antibody to a conserved conformational epitope
    Zhen Yong Keck
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Virol 82:6067-72. 2008
    A challenge in hepatitis C virus (HCV) vaccine development is defining conserved protective epitopes. A cluster of these epitopes comprises an immunodominant domain on the E2 glycoprotein, designated domain B...
  78. pmc NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11
    Claus Lundegaard
    CBS, Department of Systems Biology, Technical University of Denmark DTU, Kemitorvet Build 208, 2800 Lyngby, Denmark
    Nucleic Acids Res 36:W509-12. 2008
    ..Here, the performance is further validated and benchmarked using a large set of newly published affinity data, non-redundant to the training set. The server is free of use and available at: http://www.cbs.dtu.dk/services/NetMHC...
  79. pmc Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes
    Nicasio Mancini
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milano, Italia
    PLoS ONE 4:e8254. 2009
    Anti-hepatitis C virus (HCV) cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for ..
  80. ncbi Quantifying influenza vaccine efficacy and antigenic distance
    Vishal Gupta
    Departments of Bioengineering and Physics and Astronomy, Rice University, 6100 Main Street MS 142, Houston, TX 77005 1892, USA
    Vaccine 24:3881-8. 2006
    ..We suggest that this new measure of antigenic distance be used in the design of the annual influenza vaccine and in the interpretation of vaccine efficacy monitoring...
  81. pmc The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein
    François Helle
    Institut de Biologie de Lille UMR8161, CNRS, Université Lille I and II and Institut Pasteur de Lille, Lille, France
    J Virol 81:8101-11. 2007
    ..can limit the immunogenicity of HCV envelope proteins and restrict the binding of some antibodies to their epitopes. Here, we investigated whether these glycans can modulate the neutralizing activity of anti-HCV antibodies...
  82. ncbi Production and characterization of monoclonal antibodies against different epitopes of Ebola virus antigens
    Soraya Shahhosseini
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    J Virol Methods 143:29-37. 2007
    ..of glycoprotein (GP(1) subfragment D) were used to generate monoclonal antibodies (MAbs) against different epitopes of the viral antigens...
  83. pmc Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1
    Aran F Labrijn
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:10557-65. 2003
    ..neutralize primary isolates is due, at least in part, to steric factors that limit antibody access to the gp120 epitopes. Studies of temperature-regulated neutralization or fusion-arrested intermediates suggest that the steric effects ..
  84. pmc Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus
    Daniel X Johansson
    Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital Solna, Karolinska Institutet, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:16269-74. 2007
    ..The conformational epitopes of these two broadly reactive antibodies were overlapping yet distinct and involved amino acid residues in the ..
  85. pmc Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important
    Emeli Lundström
    Karolinska Institutet, Rheumatology Unit, Department of Medicine, Stockholm, Sweden
    Arthritis Rheum 60:1597-603. 2009
    ..We aimed to further investigate this interaction between distinct SE alleles and smoking regarding the risk of developing RA with and without anti-citrullinated protein antibodies (ACPAs)...
  86. pmc Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
    Hendrik Streeck
    Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 5:e100. 2008
    ....
  87. ncbi Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer
    Stephanie Filleur
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 65:5144-52. 2005
    ..We identified previously unknown antiangiogenic epitopes consisting of the 34-mer (residues 24-57) and a shorter proximal peptide (TGA, residues 16-26) with the critical ..
  88. pmc The c3-v4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C infection
    Penny L Moore
    National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, Johannesburg, South Africa
    J Virol 82:1860-9. 2008
    ..variable alpha2-helix was not a direct target in most cases, it contributed to the formation of neutralization epitopes as substitution of this region resulted in neutralization resistance...
  89. ncbi Epitopes involved in antibody-mediated protection from Ebola virus
    J A Wilson
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Science 287:1664-6. 2000
    ..We identified several protective mAbs directed toward five unique epitopes on Ebola glycoprotein...
  90. pmc Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma
    Pei Zhang
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:8449-54. 2007
    ..In the present study, we identified at least two epitopes at amino acid residues 412-419 (epitope I) and 434-446 (epitope II), located downstream of the hypervariable ..
  91. pmc Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex
    Annalisa Macagno
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Virol 84:1005-13. 2010
    ..that bound to a conserved epitope in the UL128 gene product, all other antibodies bound to conformational epitopes that required expression of two or more proteins of the gH/gL/UL128-131A complex...
  92. pmc Induction of epitope-specific neutralizing antibodies against West Nile virus
    Theodore Oliphant
    Departments of Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 81:11828-39. 2007
    ..virus particles, we evaluated the expression pattern and activity of antibodies against the DIII-lr and DII-fl epitopes in mouse and human serum after WNV infection...
  93. doi Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants
    Lea Barfod
    Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    J Immunol 185:7553-61. 2010
    ..gene is lower than that among var genes in general, VAR2CSA-specific Abs appear to target mainly polymorphic epitopes. This has raised doubts about the feasibility of VAR2CSA-based vaccines...
  94. doi Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure
    Andri Rauch
    University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
    Hepatology 50:1017-29. 2009
    ..are known to be important in the containment of HCV genotype 1 infection, and many genotype 1 T cell targets (epitopes) that are presented by host human leukocyte antigens (HLAs) have been identified...
  95. pmc Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers
    Jurjen H Velthuis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:1721-30. 2010
    ..Yet, conventional detection techniques (ELISPOT and HLA tetramers) require many cells and are relatively insensitive...
  96. ncbi Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments
    K Ishiguro
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    FEBS Lett 325:167-72. 1993
    ..Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3 beta...
  97. doi Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response
    Jianying Dong
    Department of Discovery Oncology, Biogen Idec, Inc, San Diego, California 92122, USA
    Mol Cancer Ther 9:2593-604. 2010
    ..We identified a spectrum of inhibitory IGF-IR antibodies with diverse binding epitopes and ligand-blocking properties...
  98. pmc Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection
    Andrew D Hislop
    CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Exp Med 195:893-905. 2002
    ..Using HLA-A2.1 or B8 tetramers specific for four lytic cycle and three latent cycle epitopes, we find marked differences in the epitope-specific composition of the T cell populations between the two phases ..
  99. pmc Genotype-specific neutralization and protection by antibodies against dengue virus type 3
    James D Brien
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Box 8051, St Louis, MO 63110, USA
    J Virol 84:10630-43. 2010
    ..Using yeast surface display, we localized the epitopes of the most strongly neutralizing MAbs to the lateral ridge of domain III (DIII) of the DENV type 3 (DENV-3) E ..
  100. ncbi Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study
    Harald Hampel
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Gen Psychiatry 61:95-102. 2004
    ..Different tau phosphoepitopes can be sensitively detected in cerebrospinal fluid (CSF)...
  101. pmc Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein
    Ania Owsianka
    MRC Virology Unit, Institute of Virology, University of Glasgow, UK
    J Virol 79:11095-104. 2005
    ..Thus, identification of a broadly neutralizing antibody that recognizes a linear epitope is likely to be of significant benefit to future vaccine and therapeutic antibody development...

Research Grants93

  1. Brucella epitope recognition by CD8+ T cells
    JEROME SCOTT HARMS; Fiscal Year: 2010
    ..Our goal is to identify specific Brucella CD8+ T cell epitopes and test their ability to protect mice against infection with virulent Brucella...
  2. Brucella epitope recognition by CD8+ T cells
    Gary Splitter; Fiscal Year: 2009
    ..Our goal is to identify specific Brucella CD8+ T cell epitopes and test their ability to protect mice against infection with virulent Brucella...
  3. SPOTTED FEVER RICKETTSIAL ANTIGENS
    David Walker; Fiscal Year: 2003
    ..The specific aims of this project will be to: 1) define the dominant CD8 T-lymphocyte epitopes of rOmpA and rOmpB of Rickettsia conorii at the oligopeptide level and identify the epitopes processed ..
  4. VARIABLE GENE USE AND PNEUMOCOCCAL IMMUNITY IN AIDS
    Liise Anne Pirofski; Fiscal Year: 2004
    ..3 ) To use Mabs with functional efficacy as defined in aim two to isolate peptide mimetics of PPS 8 and 23F epitopes, and to use the peptides to determine if PPS-elicited antibodies in patients sera recognize protective, non-..
  5. CD8+ T cell specificity in mouse models of smallpox vaccination and challenge
    David Tscharke; Fiscal Year: 2007
    ..Recently, several CD8+ T cell epitopes of VACV have been identified in mice, some of which are shared with ectromelia virus (ECTV)...
  6. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..of a new form of epitope-based dengue genetic vaccine encoding an ensemble of selected antigen peptide units (epitopes) containing the minimum antibody and cellular antigen sequences required for an effective vaccine applicable to ..
  7. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2010
    ..last decade, we created a platform technology that can be used for gene therapy to induce tolerance to multiple epitopes. In our model, LPS-activated B cells are transduced via retroviral vectors to express an Ig fusion protein with ..
  8. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
    ..last decade, we created a platform technology that can be used for gene therapy to induce tolerance to multiple epitopes. In our model, LPS-activated B cells are transduced via retroviral vectors to express an Ig fusion protein with ..
  9. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
    ..last decade, we created a platform technology that can be used for gene therapy to induce tolerance to multiple epitopes. In our model, LPS-activated B cells are transduced via retroviral vectors to express an Ig fusion protein with ..
  10. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2004
    ..following active immunization with proteolipid protein (PLP), myelin basic protein (MBP), or the immunodominant epitopes on these molecules (PLP139-151 or MBP84-104) or following the adoptive transfer of peptide-specific Th1 cells...
  11. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
    ..Antigen stimulation of CD4 T cells specific for certain HIV epitopes have been shown to render these cells more resistant to CCR5-tropic HIV and this resistance is associated with ..
  12. Novel chimeric Env vaccines to elicit broadly neutralizing antibodies against HIV
    Ling Ye; Fiscal Year: 2010
    ..hindrance exerted by the large, hypervariable, and heavily glycosylated gp120 subunit on conserved neutralizing epitopes. The gp41 subunit is less variable than gp120, and has been shown to contain conserved neutralizing epitopes such ..
  13. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..them into endogenous tumor vaccines by intratumoral injection of micelles of glycosphingolipids bearing a-gal epitopes (Gala1-3Galb1-4GlcNAc-R) (designated GSL?gal)...
  14. Protective Human Monoclonal Antibodies to HIV-1
    SUSAN B ZOLLA PAZNER; Fiscal Year: 2010
    ..to be "neutralizing Abs" that have been defined by studies of several human monoclonal Abs (mAbs) as targeting epitopes in the membrane proximal external region of gp41 and in various regions of gp120 including the CD4 binding site, ..
  15. Novel Linear Peptide Universal Malaria Vaccines
    Alberto Moreno; Fiscal Year: 2005
    ..is to evaluate the potential of synthetic linear peptide chimeras (LPCs) containing Plasmodium universal T cell epitopes and immunodominant B cell epitopes as effective malaria vaccine components...
  16. Molecular Analysis of FIV
    John Elder; Fiscal Year: 2007
    ..The Specific Aims of the proposal are to 1) Map binding epitopes of a panel of monoclonal antibodies that recognize distinct regions of the FIV envelope glycoprotein...
  17. Human Autoantibodies in Anti-GBM Disease
    Anne Christensen; Fiscal Year: 2005
    ..Although putative antigenic epitopes have been identified, little is known about the origin, structure and conformation of pathogenic human anti-GBM ..
  18. THYROID PEROXIDASE AS AN AUTOANTIGEN
    Basil Rapoport; Fiscal Year: 2005
    ..We plan the following specific studies:- 1. TPO AUTOANTIBODY EPITOPES Polyclonal TPO autoantibodies in patients' sera are primarily directed to a restricted immunodominant region (IDR)..
  19. Immune Recognition of Modified Antigen in Scleroderma
    Robert Hoffman; Fiscal Year: 2003
    ..We hypothesize that oxidative modified 70k exposes previously cryptic epitopes, driving the development of scleroderma-associated anti-70k immune response...