epitopes

Summary

Summary: Sites on an antigen that interact with specific antibodies.

Top Publications

  1. ncbi Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    Laura M Walker
    Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 326:285-9. 2009
  2. ncbi Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
    Xueling Wu
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 329:856-61. 2010
  3. ncbi Antibody neutralization and escape by HIV-1
    Xiping Wei
    Howard Hughes Medical Institute, University of Alabama at Birmingham, 720 South 20th Street, Kaul 816, Birmingham, Alabama 35294 0024, USA
    Nature 422:307-12. 2003
  4. ncbi Antibody recognition of a highly conserved influenza virus epitope
    Damian C Ekiert
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 324:246-51. 2009
  5. ncbi The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
    Nilu Goonetilleke
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, England, UK
    J Exp Med 206:1253-72. 2009
  6. ncbi Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population
    Jason A Greenbaum
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20365-70. 2009
  7. ncbi Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
    Tongqing Zhou
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Science 329:811-7. 2010
  8. ncbi Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
    Davide Corti
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    PLoS ONE 5:e8805. 2010
  9. ncbi Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans
    Katia Koelle
    Department of Ecology and Evolutionary Biology, 2019 Kraus Natural Science Building, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109 1048, USA
    Science 314:1898-903. 2006
  10. ncbi Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
    Hugo Mouquet
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nature 467:591-5. 2010

Research Grants

  1. Brucella epitope recognition by CD8+ T cells
    JEROME SCOTT HARMS; Fiscal Year: 2010
  2. Brucella epitope recognition by CD8+ T cells
    Gary Splitter; Fiscal Year: 2009
  3. SPOTTED FEVER RICKETTSIAL ANTIGENS
    David Walker; Fiscal Year: 2003
  4. VARIABLE GENE USE AND PNEUMOCOCCAL IMMUNITY IN AIDS
    Liise Anne Pirofski; Fiscal Year: 2004
  5. CD8+ T cell specificity in mouse models of smallpox vaccination and challenge
    David Tscharke; Fiscal Year: 2007
  6. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
  7. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2010
  8. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
  9. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
  10. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2004

Detail Information

Publications237 found, 100 shown here

  1. ncbi Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    Laura M Walker
    Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 326:285-9. 2009
    ..neutralizing antibodies (bNAbs), which develop over time in some HIV-1-infected individuals, define critical epitopes for HIV vaccine design...
  2. ncbi Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
    Xueling Wu
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 329:856-61. 2010
    ..Exceptionally broad HIV-1 neutralization can be achieved with individual antibodies targeted to the functionally conserved CD4bs of glycoprotein 120, an important insight for future HIV-1 vaccine design...
  3. ncbi Antibody neutralization and escape by HIV-1
    Xiping Wei
    Howard Hughes Medical Institute, University of Alabama at Birmingham, 720 South 20th Street, Kaul 816, Birmingham, Alabama 35294 0024, USA
    Nature 422:307-12. 2003
    ..contained mutations in the env gene that were unexpectedly sparse, did not map generally to known neutralization epitopes, and involved primarily changes in N-linked glycosylation...
  4. ncbi Antibody recognition of a highly conserved influenza virus epitope
    Damian C Ekiert
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 324:246-51. 2009
    ..The CR6261 epitope identified here should accelerate the design and implementation of improved vaccines that can elicit CR6261-like antibodies, as well as antibody-based therapies for the treatment of influenza...
  5. ncbi The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
    Nilu Goonetilleke
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, England, UK
    J Exp Med 206:1253-72. 2009
    ..virus escape, these first T cell responses often rapidly waned, leaving or being succeeded by T cell responses to epitopes which escaped more slowly or were invariant...
  6. ncbi Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population
    Jason A Greenbaum
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20365-70. 2009
    ..we examined the molecular basis for pre-existing immunity against S-OIV, namely the recognition of viral immune epitopes by T cells or B cells/antibodies that have been previously primed by circulating influenza strains...
  7. ncbi Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
    Tongqing Zhou
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Science 329:811-7. 2010
    ..Partial receptor mimicry and extensive affinity maturation thus facilitate neutralization of HIV-1 by natural human antibodies...
  8. ncbi Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
    Davide Corti
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    PLoS ONE 5:e8805. 2010
    ....
  9. ncbi Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans
    Katia Koelle
    Department of Ecology and Evolutionary Biology, 2019 Kraus Natural Science Building, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109 1048, USA
    Science 314:1898-903. 2006
    ..It captures the observed boom-and-bust pattern of viral evolution, with periods of antigenic stasis during which genetic diversity grows, and with episodic contraction of this diversity during cluster transitions...
  10. ncbi Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
    Hugo Mouquet
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nature 467:591-5. 2010
    ..Despite the low affinity of the polyreactive combining site, heteroligation demonstrably increases the apparent affinity of polyreactive antibodies to HIV...
  11. ncbi Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection
    E S Gray
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, Johannesburg, South Africa
    J Virol 81:6187-96. 2007
    ..were detected in 4 of 14 individuals within a year of infection, while antibodies to CD4-induced (CD4i) epitopes developed to high titers in 12 participants, in most cases before the development of autologous neutralizing ..
  12. ncbi Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
    Barton F Haynes
    Duke University School of Medicine, Durham, NC 27710, USA
    Science 308:1906-8. 2005
    ..may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus...
  13. ncbi Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission
    Cynthia A Derdeyn
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 USA
    Science 303:2019-22. 2004
    ..Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host...
  14. ncbi HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
    Peter D Kwong
    Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:678-82. 2002
    ..Because this solution is available for cell-surface receptors but not for most antibodies, conformational masking enables HIV-1 to maintain receptor binding and simultaneously to resist neutralization...
  15. ncbi Predicting the evolution of human influenza A
    R M Bush
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Science 286:1921-5. 1999
    ..However, not all codons in these sites had predictive value. Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift...
  16. ncbi The role of antibodies in HIV vaccines
    John R Mascola
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 28:413-44. 2010
    ..Thus, current vaccine design efforts have focused on a more detailed understanding of these broadly neutralizing antibodies and their epitopes to inform the design of improved vaccines.
  17. ncbi Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41
    M B Zwick
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:10892-905. 2001
    ..Despite the apparent linear nature of the epitopes of Z13 and 4E10, denaturation of recombinant envelope protein reduces the binding of these MAbs, suggesting some ..
  18. ncbi Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120
    Lei Chen
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 326:1123-7. 2009
    ..This incompatibility, the consequence of slight differences in CD4BS recognition, renders HIV-1 resistant to all but the most accurately targeted antibodies...
  19. ncbi Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein
    Ania M Owsianka
    Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 89:653-9. 2008
    ..We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein...
  20. ncbi Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions
    Erin M Scherer
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:1529-34. 2010
    ....
  21. ncbi Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009
    ....
  22. ncbi The immune epitope database 2.0
    Randi Vita
    La Jolla Institute for Allergy and Immunology, Center for Infectious Disease, Allergy and Asthma Research, 9420 Athena Circle, La Jolla, CA 92037, USA
    Nucleic Acids Res 38:D854-62. 2010
    The Immune Epitope Database (IEDB, www.iedb.org) provides a catalog of experimentally characterized B and T cell epitopes, as well as data on Major Histocompatibility Complex (MHC) binding and MHC ligand elution experiments...
  23. ncbi Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls
    Frank C Arnett
    Division of Rheumatology, Department of Internal Medicine, The University of Texas Health Science Center at Houston UTHSC H, 6431 Fannin Street, MSB 5 270, Houston, TX 77030, USA
    Ann Rheum Dis 69:822-7. 2010
    ..human leucocyte antigen-class II (HLA-class II) (DRB1, DQB1, DQA1 and DPB1) alleles, haplotypes and shared epitopes associated with scleroderma (systemic sclerosis (SSc)) and its subphenotypes in a large multi-ethnic US cohort by ..
  24. ncbi Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes
    Dorothea Bankwitz
    Division of Experimental Virology, TWINCORE Center for Experimental and Clinical Infection Research, Feodor Lynen Strasse 7 9, 30625 Hannover, Germany
    J Virol 84:5751-63. 2010
    ..Moreover, they indicate that HVR1 obstructs the viral CD81 binding site and conserved neutralizing epitopes. These functions likely optimize virus replication, facilitate immune escape, and thus foster establishment and ..
  25. ncbi Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions
    S Moses Dennison
    Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Virol 83:10211-23. 2009
    ..virus type 1 (HIV-1) gp41 involves both the viral membrane and gp41 membrane proximal external region (MPER) epitopes. In this study, we have used several biophysical tools to examine the secondary structure, orientation, and depth ..
  26. ncbi Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial
    Morgane Rolland
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    Nat Med 17:366-71. 2011
    ..whether the vaccine exerted selective T cell pressure on breakthrough viruses, we identified potential T cell epitopes in the founder sequences and compared them to epitopes in the vaccine...
  27. ncbi Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity
    Yury I Miller
    Department of Medicine MC0682, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Circ Res 108:235-48. 2011
    ..produce reactive oxygen species, which damage lipids, proteins and DNA, generating "oxidation-specific" epitopes. In this review, we discuss the hypothesis that such common oxidation-specific epitopes are a major target of ..
  28. ncbi Structural definition of a conserved neutralization epitope on HIV-1 gp120
    Tongqing Zhou
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 445:732-7. 2007
    ..A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1...
  29. ncbi Prediction of continuous B-cell epitopes in an antigen using recurrent neural network
    Sudipto Saha
    Institute of Microbial Technology, Chandigarh, India
    Proteins 65:40-8. 2006
    B-cell epitopes play a vital role in the development of peptide vaccines, in diagnosis of diseases, and also for allergy research. Experimental methods used for characterizing epitopes are time consuming and demand large resources...
  30. ncbi Elicitation of structure-specific antibodies by epitope scaffolds
    Gilad Ofek
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:17880-7. 2010
    ..Epitope scaffolds thus provide a means to elicit antibodies that recognize a predetermined target shape and sequence, even if that shape is transient in nature, and a means by which to dissect factors influencing such elicitation...
  31. ncbi NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11
    Claus Lundegaard
    CBS, Department of Systems Biology, Technical University of Denmark DTU, Kemitorvet Build 208, 2800 Lyngby, Denmark
    Nucleic Acids Res 36:W509-12. 2008
    ..Here, the performance is further validated and benchmarked using a large set of newly published affinity data, non-redundant to the training set. The server is free of use and available at: http://www.cbs.dtu.dk/services/NetMHC...
  32. ncbi The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein
    François Helle
    Institut de Biologie de Lille UMR8161, CNRS, Université Lille I and II and Institut Pasteur de Lille, Lille, France
    J Virol 81:8101-11. 2007
    ..can limit the immunogenicity of HCV envelope proteins and restrict the binding of some antibodies to their epitopes. Here, we investigated whether these glycans can modulate the neutralizing activity of anti-HCV antibodies...
  33. ncbi Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes
    Nicasio Mancini
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Milano, Italia
    PLoS ONE 4:e8254. 2009
    Anti-hepatitis C virus (HCV) cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for ..
  34. ncbi Production and characterization of monoclonal antibodies against different epitopes of Ebola virus antigens
    Soraya Shahhosseini
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    J Virol Methods 143:29-37. 2007
    ..of glycoprotein (GP(1) subfragment D) were used to generate monoclonal antibodies (MAbs) against different epitopes of the viral antigens...
  35. ncbi Quantifying influenza vaccine efficacy and antigenic distance
    Vishal Gupta
    Departments of Bioengineering and Physics and Astronomy, Rice University, 6100 Main Street-MS 142, Houston, TX 77005-1892, USA
    Vaccine 24:3881-8. 2006
    ..We suggest that this new measure of antigenic distance be used in the design of the annual influenza vaccine and in the interpretation of vaccine efficacy monitoring...
  36. ncbi Humoral immune responses of dengue fever patients using epitope-specific serotype-2 virus-like particle antigens
    Wayne D Crill
    Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Service, Fort Collins, CO, USA
    PLoS ONE 4:e4991. 2009
    ..DENV-2 envelope (E) protein epitope-specific antigens and measure immunoglobulin responses to three distinct epitopes in DENV-2 infected human serum samples...
  37. ncbi Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope
    Gilad Ofek
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Instiutes of Health, Bethesda, MD 20892, USA
    J Virol 78:10724-37. 2004
    ..Based on these structural and biochemical results, immunization strategies for eliciting 2F5- and 4E10-like broadly neutralizing anti-HIV-1 antibodies are proposed...
  38. ncbi Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1
    Aran F Labrijn
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:10557-65. 2003
    ..neutralize primary isolates is due, at least in part, to steric factors that limit antibody access to the gp120 epitopes. Studies of temperature-regulated neutralization or fusion-arrested intermediates suggest that the steric effects ..
  39. ncbi Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus
    Daniel X Johansson
    Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital Solna, Karolinska Institutet, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:16269-74. 2007
    ..The conformational epitopes of these two broadly reactive antibodies were overlapping yet distinct and involved amino acid residues in the ..
  40. ncbi Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
    James W Huleatt
    VaxInnate Corporation, 300 George Street, New Haven, CT 06511, USA
    Vaccine 26:201-14. 2008
    ..These data demonstrate that the linkage of specific TLR ligand with influenza M2e yields a vaccine candidate that offers significant promise for widespread protection against multiple influenza A virus strains...
  41. ncbi Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important
    Emeli Lundström
    Karolinska Institutet, Rheumatology Unit, Department of Medicine, Stockholm, Sweden
    Arthritis Rheum 60:1597-603. 2009
    ..We aimed to further investigate this interaction between distinct SE alleles and smoking regarding the risk of developing RA with and without anti-citrullinated protein antibodies (ACPAs)...
  42. ncbi Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells
    Hendrik Streeck
    Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 5:e100. 2008
    ....
  43. ncbi The c3-v4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C infection
    Penny L Moore
    National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, Johannesburg, South Africa
    J Virol 82:1860-9. 2008
    ..variable alpha2-helix was not a direct target in most cases, it contributed to the formation of neutralization epitopes as substitution of this region resulted in neutralization resistance...
  44. ncbi Epitopes involved in antibody-mediated protection from Ebola virus
    J A Wilson
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Science 287:1664-6. 2000
    ..We identified several protective mAbs directed toward five unique epitopes on Ebola glycoprotein...
  45. ncbi Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer
    Stephanie Filleur
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 65:5144-52. 2005
    ..We identified previously unknown antiangiogenic epitopes consisting of the 34-mer (residues 24-57) and a shorter proximal peptide (TGA, residues 16-26) with the critical ..
  46. ncbi Genotype-specific neutralization and protection by antibodies against dengue virus type 3
    James D Brien
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Box 8051, St Louis, MO 63110, USA
    J Virol 84:10630-43. 2010
    ..Using yeast surface display, we localized the epitopes of the most strongly neutralizing MAbs to the lateral ridge of domain III (DIII) of the DENV type 3 (DENV-3) E ..
  47. ncbi Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection
    Andrew D Hislop
    CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Exp Med 195:893-905. 2002
    ..Using HLA-A2.1 or B8 tetramers specific for four lytic cycle and three latent cycle epitopes, we find marked differences in the epitope-specific composition of the T cell populations between the two phases ..
  48. ncbi Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response
    Jianying Dong
    Department of Discovery Oncology, Biogen Idec, Inc, San Diego, California 92122, USA
    Mol Cancer Ther 9:2593-604. 2010
    ..We identified a spectrum of inhibitory IGF-IR antibodies with diverse binding epitopes and ligand-blocking properties...
  49. ncbi Induction of epitope-specific neutralizing antibodies against West Nile virus
    Theodore Oliphant
    Departments of Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 81:11828-39. 2007
    ..virus particles, we evaluated the expression pattern and activity of antibodies against the DIII-lr and DII-fl epitopes in mouse and human serum after WNV infection...
  50. ncbi Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers
    Jurjen H Velthuis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:1721-30. 2010
    ..Yet, conventional detection techniques (ELISPOT and HLA tetramers) require many cells and are relatively insensitive...
  51. ncbi Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure
    Andri Rauch
    University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
    Hepatology 50:1017-29. 2009
    ..are known to be important in the containment of HCV genotype 1 infection, and many genotype 1 T cell targets (epitopes) that are presented by host human leukocyte antigens (HLAs) have been identified...
  52. ncbi Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein
    Ania Owsianka
    MRC Virology Unit, Institute of Virology, University of Glasgow, UK
    J Virol 79:11095-104. 2005
    ..Thus, identification of a broadly neutralizing antibody that recognizes a linear epitope is likely to be of significant benefit to future vaccine and therapeutic antibody development...
  53. ncbi Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 2054, USA
    Proc Natl Acad Sci U S A 107:18950-5. 2010
    ....
  54. ncbi Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments
    K Ishiguro
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    FEBS Lett 325:167-72. 1993
    ..Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3 beta...
  55. ncbi Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex
    Annalisa Macagno
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Virol 84:1005-13. 2010
    ..that bound to a conserved epitope in the UL128 gene product, all other antibodies bound to conformational epitopes that required expression of two or more proteins of the gH/gL/UL128-131A complex...
  56. ncbi Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study
    Harald Hampel
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Gen Psychiatry 61:95-102. 2004
    ..Different tau phosphoepitopes can be sensitively detected in cerebrospinal fluid (CSF)...
  57. ncbi Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development
    Zuzana Staneková
    Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic
    Virol J 7:351. 2010
    ..Combination of chosen conserved antigens inducing cross-protective antibody response with epitopes activating also cross-protective cytotoxic T-cells would offer an attractive strategy for improving protection ..
  58. ncbi Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants
    Lea Barfod
    Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    J Immunol 185:7553-61. 2010
    ..gene is lower than that among var genes in general, VAR2CSA-specific Abs appear to target mainly polymorphic epitopes. This has raised doubts about the feasibility of VAR2CSA-based vaccines...
  59. ncbi Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm
    Benoit Stijlemans
    Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium
    J Biol Chem 279:1256-61. 2004
    ..involves a dense packing of variant surface glycoproteins (VSG) exposing only highly variable and immuno-dominant epitopes to the immune system, whereas conserved epitopes become inaccessible for large molecules...
  60. ncbi Heat shock protein 60: identification of specific epitopes for binding to primary macrophages
    Christiane Habich
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute, Heinrich Heine University of Dusseldorf, D 40225 Dusseldorf, Germany
    FEBS Lett 580:115-20. 2006
    ..Analysis of different pro- and eukaryotic HSP60 species indicated that phylogenetically separate HSP60 species use different binding sites on primary macrophages...
  61. ncbi Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA
    Marion Avril
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
    Infect Immun 76:1791-800. 2008
    ..Antibodies did not target conserved epitopes exposed in all VAR2CSA alleles; however, antisera to several DBL domains cross-reacted on parasite isolates that ..
  62. ncbi Epitope identification and discovery using phage display libraries: applications in vaccine development and diagnostics
    Lin Fa Wang
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong 3220, Victoria, Australia
    Curr Drug Targets 5:1-15. 2004
    Antigenic epitopes are the part (contact points) of an antigen involved in specific interaction with the antigen-binding site (the paratope) of an antibody or a T-cell receptor...
  63. ncbi In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes
    Birke Bartosch
    , , IFR 128, , , 69364 Lyon Cedex 07, France
    Proc Natl Acad Sci U S A 100:14199-204. 2003
    ..directed not only to epitope(s) in the hypervariable region of the E2 envelope protein but also to one or more epitopes elsewhere in the envelope of the virus...
  64. ncbi Reverse vaccinology: developing vaccines in the era of genomics
    Alessandro Sette
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92130, USA
    Immunity 33:530-41. 2010
    ..targets in bacteria, parasites, and large viruses and revealed virtually all their CD4(+) and CD8(+) T cell epitopes. The genomic information was first used for the development of a vaccine against serogroup B meningococcus, and ..
  65. ncbi In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth
    Xiaoying Shen
    Duke Human Vaccine Institute, Duke University Medicine Center, Durham, NC 27710, USA
    J Virol 83:3617-25. 2009
    ..serum antibodies from an HIV-infected subject that both were broadly neutralizing and specifically targeted MPER epitopes that overlap the 2F5 epitope...
  66. ncbi Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope
    Bruno E Correia
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Structure 18:1116-26. 2010
    Broadly cross-reactive monoclonal antibodies define epitopes for vaccine development against HIV and other highly mutable viruses...
  67. ncbi Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Clin Vaccine Immunol 17:87-97. 2010
    Recently, major species-specific antibody epitopes in three immunoreactive tandem repeat proteins (TRPs) of Ehrlichia chaffeensis, TRP32, TRP47, and TRP120, have been identified and molecularly characterized within tandem repeat (TR) ..
  68. ncbi Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis
    Emeli Lundström
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:924-30. 2009
    ....
  69. ncbi Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy
    Hui Chen
    Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, Beijing 100005, China
    J Biol Chem 283:12528-37. 2008
    ..However, few tumor antigens recognized by TCRgammadelta have been defined so far. To investigate antigenic epitopes/proteins recognized by gammadeltaT cells, we have established a new immunobiochemical strategy that uses ..
  70. ncbi An HPV 16 L1-based chimeric human papilloma virus-like particles containing a string of epitopes produced in plants is able to elicit humoral and cytotoxic T-cell activity in mice
    Georgina Paz De la Rosa
    Centro de Investigación y de Estudios Avanzados Cinvestav, Unidad Irapuato, km, 9, 6 libramiento norte, 36500 Carretera Irapuato León, Irapuato, Guanajuato, Mexico
    Virol J 6:2. 2009
    ..Several HPV genes have been expressed in plants, including L1, which can self-assemble into virus-like particles. A plant-based, dual prophylactic/therapeutic vaccine remains an attractive possibility...
  71. ncbi A comprehensive toolkit of plant cell wall glycan-directed monoclonal antibodies
    Sivakumar Pattathil
    Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, USA
    Plant Physiol 153:514-25. 2010
    ..The mAbs could be resolved into 19 clades of antibodies that recognize distinct epitopes present on all major classes of plant cell wall glycans, including arabinogalactans (both protein- and ..
  72. ncbi Identification of an H-2D(b)-restricted CD8+ cytotoxic T lymphocyte epitope in the matrix protein of respiratory syncytial virus
    John A Rutigliano
    Vaccine Research Center, NIAID, National Institutes of Health, Building 40, Room 2502, 40 Convent Drive, MSC 3017, Bethesda, MD 20892-3017, USA
    Virology 337:335-43. 2005
    ..Identification of class I MHC-restricted CTL epitopes is critical in elucidating mechanisms of CTL responses against viral infections...
  73. ncbi The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
    Jessica L Teeling
    Genmab, Utrecht, The Netherlands
    J Immunol 177:362-71. 2006
    ..We conclude that recognition of the novel epitope cooperates with slow off-rate in determining the activity of CD20 Ab in activation of complement and induction of tumor cell lysis...
  74. ncbi Hepatitis C virus mutation affects proteasomal epitope processing
    Ulrike Seifert
    Institute of Biochemistry, Charit, Humboldt University, Berlin, Germany
    J Clin Invest 114:250-9. 2004
    ....
  75. ncbi Epitope analysis for influenza vaccine design
    Enrique T Munoz
    Department of Bioengineering and Department of Physics and Astronomy, Rice University Houston, TX 77005 1892, USA
    Vaccine 23:1144-8. 2005
    ..from statistical mechanics to quantify the non-monotonic immune response that results from antigenic drift in the epitopes of the hemagglutinin and neuraminidase proteins...
  76. ncbi Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes
    Hans H Wandall
    Center for Glycomics, Departments of Cellular and Molecular Medicine and Oral Diagnostics, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark
    Cancer Res 70:1306-13. 2010
    ..An O-glycopeptide microarray was developed that detected IgG antibodies to aberrant O-glycopeptide epitopes in patients vaccinated with a keyhole limpet hemocyanin-conjugated truncated MUC1 peptide...
  77. ncbi Characterization of epitopes for neutralizing monoclonal antibodies to classical swine fever virus E2 and Erns using phage-displayed random peptide library
    F Zhang
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
    Arch Virol 151:37-54. 2006
    ..Here we report the identification of multiple neutralizing epitopes on these proteins by screening a phage-displayed random peptide library with CSFV-specific neutralizing ..
  78. ncbi Recognition of variant HIV-1 epitopes from diverse viral subtypes by vaccine-induced CTL
    Denise M McKinney
    Epimmune, San Diego, CA 92121, USA
    J Immunol 173:1941-50. 2004
    Recognition by CD8(+) T lymphocytes (CTL) of epitopes that are derived from conserved gene products, such as Gag and Pol, is well documented and conceptually supports the development of epitope-based vaccines for use against diverse HIV-1 ..
  79. ncbi Phage display for epitope determination: a paradigm for identifying receptor-ligand interactions
    Merrill J Rowley
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Biotechnol Annu Rev 10:151-88. 2004
    ..of protein and non-protein nature are widely studied in biology and have particular utilities, but the precise epitopes recognized are seldom well defined...
  80. ncbi Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains
    Paolo Lusso
    Unit of Human Virology, Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Virol 79:6957-68. 2005
    ..For the conserved neutralization epitopes hitherto described, antibody accessibility is reportedly unrelated to the viral coreceptor usage phenotype...
  81. ncbi An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes
    Hans Bakker
    Business Unit Bioscience, Plant Research International, Wageningen University and Research Center, Droevendaalsesteeg 1, 6708 PB, Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 103:7577-82. 2006
    ..Hence, a transgenic plant expressing the hybrid GalT might yield more effective and safer monoclonals for therapeutic purposes than WT plants and even transgenic plants expressing the unchanged GalT...
  82. ncbi Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse
    R H Scofield
    Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Department of Veterans Affairs Medical Center, and WK Warren Medical Research Institute, Oklahoma City 73104, USA
    Arthritis Rheum 42:1017-24. 1999
    ..The purpose of this study was to determine the ability of several different peptides from 60-kd Ro to induce expansion of the immune response to the Ro/La RNP particle...
  83. ncbi Colocalization of tau and alpha-synuclein epitopes in Lewy bodies
    Takashi Ishizawa
    Department of Pathology (Neuropathology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Neuropathol Exp Neurol 62:389-97. 2003
    ..rabbit polyclonal antibody to alpha-synuclein and a panel of monoclonal antibodies to phospho- and nonphospho-tau epitopes (Alz50, CP9, CP13, PG5, TG3, PHFI) that spanned the length of the tau molecule...
  84. ncbi Production of a monoclonal antibody in plants with a humanized N-glycosylation pattern
    Matthias Schähs
    Institute of Applied Genetics and Cell Biology, BOKU Wien, Austria
    Plant Biotechnol J 5:657-63. 2007
    ..the presence of beta1,2-xylose and core alpha1,3-fucose residues on complex N-linked glycans, as these N-glycan epitopes are immunogenic in mammals...
  85. ncbi Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infection
    Emma L Turnbull
    Viral Immunology Group, Jenner Institute, University of Oxford, Compton, United Kingdom
    J Immunol 182:7131-45. 2009
    ..These observations document the preferential expansion of CD8(+) T cells recognizing a subset of epitopes during the viral burst in acute HIV-1 infection and suggest that the nature of the initial, very rapidly expanded ..
  86. ncbi Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis
    Hong Xin
    Department of Pediatrics, Louisiana State University Health Sciences Center and Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
    Proc Natl Acad Sci U S A 105:13526-31. 2008
    ..This approach based on fully synthetic chemically defined immunogens should be generally useful in vaccine development...
  87. ncbi Design and pre-clinical evaluation of a universal HIV-1 vaccine
    Sven Létourneau
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, Oxford, United Kingdom
    PLoS ONE 2:e984. 2007
    ..One of the big roadblocks in development of HIV-1/AIDS vaccines is the enormous diversity of HIV-1, which could limit the value of any HIV-1 vaccine candidate currently under test...
  88. ncbi Force-dependent polymorphism in type IV pili reveals hidden epitopes
    Nicolas Biais
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 107:11358-63. 2010
    ..Equally important, we show that the force-induced conformation exposes hidden epitopes previously buried in the Tfp fiber. We postulate that this transition provides a means for N...
  89. ncbi Conserved structural elements in the V3 crown of HIV-1 gp120
    Xunqing Jiang
    Department of Biochemistry, New York University School of Medicine, New York, New York, USA
    Nat Struct Mol Biol 17:955-61. 2010
    ..These conserved elements could serve as epitopes to be targeted by a vaccine against HIV-1...
  90. ncbi Glycomic analysis of N-linked carbohydrate epitopes from CD24 of mouse brain
    Christina Bleckmann
    Institute of Biochemistry, University of Giessen, Friedrichstrasse 24, D 35392 Giessen, Germany
    J Proteome Res 8:567-82. 2009
    ..Our data revealed a highly heterogeneous pattern of mainly complex type glycans expressing distinct carbohydrate epitopes, like 3-linked sialic acid, Le(X) or blood group H antigens, bisecting N-acetylglucosamine residues and N-..
  91. ncbi Lipid transfer proteins from Rosaceae fruits share consensus epitopes responsible for their IgE-binding cross-reactivity
    Jean Philippe Borges
    Surfaces Cellulaires et Signalisation chez les Végétaux, UMR Université Paul Sabatier CNRS 5546, 24 Chemin de Borde Rouge, 31326 Castanet Tolosan, France
    Biochem Biophys Res Commun 365:685-90. 2008
    Four IgE-binding epitopes have been characterized that cover a large area (40%) of the molecular surface of lipid transfer protein allergens of Rosaceae (apple, peach, apricot, and plum)...
  92. ncbi Detection of apoptosis in vivo using antibodies against caspase-induced neo-epitopes
    Sabine Jakob
    Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland
    Methods 44:255-61. 2008
    ..Furthermore, we evaluate the effect of tissue pretreatment and antigen retrieval on the sensitivity of apoptosis detection, background staining and maintenance of tissue morphology...
  93. ncbi Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step
    Michelle C Sabo
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, Box 8051, Saint Louis, MO 63110, USA
    J Virol 85:7005-19. 2011
    ..16 blocked attachment to SR-B1 only. Using yeast surface display, we localized epitopes for the neutralizing MAbs on the E2 protein. Two of the strongly inhibitory MAbs, H77.16 and J6...
  94. ncbi REMUS: a tool for identification of unique peptide segments as epitopes
    Tun Wen Pai
    Department of Computer Science and Engineering, National Taiwan Ocean University, Keelung, Taiwan, Republic of China
    Nucleic Acids Res 34:W198-201. 2006
    ..the amino acids, frequency of appearance and biological properties such as priority for serving as candidates for epitopes where antibodies recognize...
  95. ncbi Characterisation of the transcription factor, SIX5, using a new panel of monoclonal antibodies
    Y Chan N Pham
    Biochemistry Group, North East Wales Institute, Mold Road, Wrexham, United Kingdom
    J Cell Biochem 95:990-1001. 2005
    ..We have produced a new panel of 18 monoclonal antibodies (mAbs) that recognise at least four different epitopes in order to identify authentic human SIX5 protein in cells and tissues...
  96. ncbi A mouse monoclonal antibody to the TSHR
    Hanna Stankowiak-Kulpa
    FIRS Laboratories, RSR Ltd, Llanishen, Cardiff, UK
    Arch Immunol Ther Exp (Warsz) 53:345-51. 2005
    ..The 3C3 mAb we produced was found to inhibit binding of TSH to human (h)TSHR but not to porcine (p)TSHR...
  97. ncbi Immune responses of selected phagotopes from monoclonal antibodies of Burkholderia pseudomallei
    Narisorn Na-ngam
    Department of Veterinary Medicine, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand
    Southeast Asian J Trop Med Public Health 39:443-51. 2008
    ..The study demonstrates the feasibility of identifying mimotopes through screening of phage-displayed random peptide libraries with B. pseudomallei MAbs...
  98. ncbi Characterization of cross-reactive and serotype-specific epitopes on the nucleocapsid proteins of hantaviruses
    Nicole D Tischler
    Fundación Ciencia para la Vida, Nunoa, Santiago, Chile
    Virus Res 135:1-9. 2008
    ..Here we report on epitopes involved in serotype-specific and cross-reactive recognition of the N proteins of hantaviruses using monoclonal ..
  99. ncbi Molecular basis for the binding polyspecificity of an anti-cholera toxin peptide 3 monoclonal antibody
    Livia Otte
    Institut fur Medizinische Immunologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Mol Recognit 19:49-59. 2006
    ..However, the overall binding conformation of the peptides is similar. Together, our results support the theory of a general polyspecific potential of mAbs...
  100. ncbi Conformation-specific antibodies reveal distinct actin structures in the nucleus and the cytoplasm
    C A Schoenenberger
    M E Müller Institute for Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Struct Biol 152:157-68. 2005
    ..Our results indicate that distinct actin conformations and/or structures are present in the nucleus and the cytoplasm of different cell types and that their distribution varies in response to external signals...
  101. ncbi Characterization and application of monoclonal antibodies against human endothelin B receptor expressed in insect cells
    Tomohiro Yamaguchi
    Department of Biophysics, Graduate School of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan
    Biotechnol Lett 26:293-9. 2004
    ..Five typical monoclonal antibodies were characterized further for their recognition. The epitopes for the 2A5, 9A3 and 21A1 antibodies were mapped within the N-terminal extracellular sequences, V71-I85 and E27-..

Research Grants93

  1. Brucella epitope recognition by CD8+ T cells
    JEROME SCOTT HARMS; Fiscal Year: 2010
    ..Our goal is to identify specific Brucella CD8+ T cell epitopes and test their ability to protect mice against infection with virulent Brucella...
  2. Brucella epitope recognition by CD8+ T cells
    Gary Splitter; Fiscal Year: 2009
    ..Our goal is to identify specific Brucella CD8+ T cell epitopes and test their ability to protect mice against infection with virulent Brucella...
  3. SPOTTED FEVER RICKETTSIAL ANTIGENS
    David Walker; Fiscal Year: 2003
    ..The specific aims of this project will be to: 1) define the dominant CD8 T-lymphocyte epitopes of rOmpA and rOmpB of Rickettsia conorii at the oligopeptide level and identify the epitopes processed ..
  4. VARIABLE GENE USE AND PNEUMOCOCCAL IMMUNITY IN AIDS
    Liise Anne Pirofski; Fiscal Year: 2004
    ..3 ) To use Mabs with functional efficacy as defined in aim two to isolate peptide mimetics of PPS 8 and 23F epitopes, and to use the peptides to determine if PPS-elicited antibodies in patients sera recognize protective, non-..
  5. CD8+ T cell specificity in mouse models of smallpox vaccination and challenge
    David Tscharke; Fiscal Year: 2007
    ..Recently, several CD8+ T cell epitopes of VACV have been identified in mice, some of which are shared with ectromelia virus (ECTV)...
  6. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..of a new form of epitope-based dengue genetic vaccine encoding an ensemble of selected antigen peptide units (epitopes) containing the minimum antibody and cellular antigen sequences required for an effective vaccine applicable to ..
  7. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2010
    ..last decade, we created a platform technology that can be used for gene therapy to induce tolerance to multiple epitopes. In our model, LPS-activated B cells are transduced via retroviral vectors to express an Ig fusion protein with ..
  8. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
    ..last decade, we created a platform technology that can be used for gene therapy to induce tolerance to multiple epitopes. In our model, LPS-activated B cells are transduced via retroviral vectors to express an Ig fusion protein with ..
  9. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
    ..last decade, we created a platform technology that can be used for gene therapy to induce tolerance to multiple epitopes. In our model, LPS-activated B cells are transduced via retroviral vectors to express an Ig fusion protein with ..
  10. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2004
    ..following active immunization with proteolipid protein (PLP), myelin basic protein (MBP), or the immunodominant epitopes on these molecules (PLP139-151 or MBP84-104) or following the adoptive transfer of peptide-specific Th1 cells...
  11. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
    ..Antigen stimulation of CD4 T cells specific for certain HIV epitopes have been shown to render these cells more resistant to CCR5-tropic HIV and this resistance is associated with ..
  12. Human Autoantibodies in Anti-GBM Disease
    Anne Christensen; Fiscal Year: 2005
    ..Although putative antigenic epitopes have been identified, little is known about the origin, structure and conformation of pathogenic human anti-GBM ..
  13. Novel chimeric Env vaccines to elicit broadly neutralizing antibodies against HIV
    Ling Ye; Fiscal Year: 2010
    ..hindrance exerted by the large, hypervariable, and heavily glycosylated gp120 subunit on conserved neutralizing epitopes. The gp41 subunit is less variable than gp120, and has been shown to contain conserved neutralizing epitopes such ..
  14. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..them into endogenous tumor vaccines by intratumoral injection of micelles of glycosphingolipids bearing a-gal epitopes (Gala1-3Galb1-4GlcNAc-R) (designated GSL?gal)...
  15. Protective Human Monoclonal Antibodies to HIV-1
    SUSAN B ZOLLA PAZNER; Fiscal Year: 2010
    ..to be "neutralizing Abs" that have been defined by studies of several human monoclonal Abs (mAbs) as targeting epitopes in the membrane proximal external region of gp41 and in various regions of gp120 including the CD4 binding site, ..
  16. Novel Linear Peptide Universal Malaria Vaccines
    Alberto Moreno; Fiscal Year: 2005
    ..is to evaluate the potential of synthetic linear peptide chimeras (LPCs) containing Plasmodium universal T cell epitopes and immunodominant B cell epitopes as effective malaria vaccine components...
  17. Molecular Analysis of FIV
    John Elder; Fiscal Year: 2007
    ..The Specific Aims of the proposal are to 1) Map binding epitopes of a panel of monoclonal antibodies that recognize distinct regions of the FIV envelope glycoprotein...
  18. THYROID PEROXIDASE AS AN AUTOANTIGEN
    Basil Rapoport; Fiscal Year: 2005
    ..We plan the following specific studies:- 1. TPO AUTOANTIBODY EPITOPES Polyclonal TPO autoantibodies in patients' sera are primarily directed to a restricted immunodominant region (IDR)..
  19. Immune Recognition of Modified Antigen in Scleroderma
    Robert Hoffman; Fiscal Year: 2003
    ..We hypothesize that oxidative modified 70k exposes previously cryptic epitopes, driving the development of scleroderma-associated anti-70k immune response...