Genomes and Genes
Summary: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Publications304 found, 100 shown here
- The development of allergic inflammationStephen J Galli
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
Nature 454:445-54. 2008..In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic ..
- A mechanism for the initiation of allergen-induced T helper type 2 responsesCaroline L Sokol
Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connceticut 06510, USA
Nat Immunol 9:310-8. 2008Both metazoan parasites and simple protein allergens induce T helper type 2 (TH2) immune responses, but the mechanisms by which the innate immune system senses these stimuli are unknown...
- Allergenicity resulting from functional mimicry of a Toll-like receptor complex proteinAurelien Trompette
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nature 457:585-8. 2009..Why particular proteins tend to act as allergens in susceptible hosts is a fundamental mechanistic question that remains largely unanswered...
- Allergen-specific immunotherapy with recombinant grass pollen allergensMarek Jutel
Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland
J Allergy Clin Immunol 116:608-13. 2005..Recombinant DNA technology has enabled the cloning of many allergens, thus facilitating investigations aimed at improving efficacy and safety of immunotherapy.
- IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapyMarek Jutel
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Eur J Immunol 33:1205-14. 2003The regulation of normal and allergic immune responses to airborne allergens in the mucosa is still poorly understood, and the mechanism of specific immunotherapy (SIT) in normalizing the allergic response to such allergens is currently ..
- Loosening of plant cell walls by expansinsD J Cosgrove
Department of Biology, Pennsylvania State University, University Park 16802, USA
Nature 407:321-6. 2000..Expansin's action has puzzling implications for plant cell-wall structure. The recent explosion of gene sequences and expression data has given new hints of additional biological functions for expansins...
- Mechanisms and treatment of allergic disease in the big picture of regulatory T cellsCezmi A Akdis
Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009..Their identification as key regulators of immunologic processes in peripheral tolerance to allergens has opened an important era in the prevention and treatment of allergic diseases...
- Immunological mechanisms of allergen-specific immunotherapyMark Larché
Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Nat Rev Immunol 6:761-71. 2006..Approaches to address this problem include the use of modified allergens, novel adjuvants and alternative routes of administration...
- The asthma epidemicWaltraud Eder
University Children's Hospital, Munich, Germany
N Engl J Med 355:2226-35. 2006
- Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional studyT Platts-Mills
University of Virginia Asthma and Allergic Diseases Center, University of Virginia Department of Medicine, Charlottesville, USA
Lancet 357:752-6. 2001Although asthma is strongly associated with immediate hypersensitivity to indoor allergens, several studies have suggested that a cat in the house can decrease the risk of asthma...
- Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection systemE Scala
Centre for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
Clin Exp Allergy 40:911-21. 2010..This can be carried out applying the test in the routine diagnostic work-up...
- Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response studyT Werfel
Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
Allergy 61:202-5. 2006..is able to improve the eczema in patients with atopic dermatitis who are sensitized to house dust mite allergens and reduces the need for topical corticosteroids...
- The role of protein glycosylation in allergyFriedrich Altmann
Divison of Biochemistry, Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
Int Arch Allergy Immunol 142:99-115. 2007..and suppress anti-CCD IgE without interference from peptide epitopes can be best met by artificial glycoprotein allergens. Hydroxyproline-linked arabinose (single beta-arabinofuranosyl residues) has been identified as a new IgE-..
- Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatusWilliam C Nierman
The Institute for Genomic Research, Rockville, Maryland 20850, USA
Nature 438:1151-6. 2005..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus...
- Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approachG Frank Gerberick
The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45252, USA
Toxicol Sci 97:417-27. 2007..One unifying characteristic of chemical allergens is the requirement that they react with proteins for the effective induction of skin sensitization...
- The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activityPierre Joseph Royer
School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, United Kingdom
J Immunol 185:1522-31. 2010..We have investigated the ability of MR to recognize glycosylated allergens. Using a gene silencing strategy, we have specifically inhibited the expression of MR on human monocyte-derived ..
- Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene familyIain W Chalmers
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
BMC Genomics 9:89. 2008..protein/Tpx-1/Ag5/PR-1/Sc7 (SCP/TAPS) domain is found across phyla and is a major structural feature of insect allergens, mammalian sperm proteins and parasitic nematode secreted molecules...
- Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic diseaseEleanor M Ling
Department of Allergy, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
Lancet 363:608-15. 2004..Allergic diseases are frequent and rising in prevalence, and result from activation of T-helper (Th) 2 cells by allergens. CD4+CD25+ regulatory T cells suppress T-cell activation in vitro and prevent pathological findings in animal ..
- Role of interleukin 10 in specific immunotherapyC A Akdis
Swiss Institute of Allergy and Asthma Research, CH 7270 Davos, Switzerland
J Clin Invest 102:98-106. 1998..Accordingly, increased IL-10 production by SIT causes specific anergy in peripheral T cells, and regulates specific IgE and IgG4 production toward normal IgG4-related immunity...
- A mouse model for food allergy using intraperitoneal sensitizationRebecca J Dearman
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
Methods 41:91-8. 2007..most foreign proteins are immunogenic (able to induce IgG antibody responses), relatively few are important food allergens with the capacity to provoke IgE antibody production...
- Noninjection routes for immunotherapyGiorgio Walter Canonica
Division of Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
J Allergy Clin Immunol 111:437-48; quiz 449. 2003..Although the long-lasting efficacy has been recently documented for the sublingual route, several points still need to be elucidated, including mechanisms of action, optimal dosage, cost-effectiveness, and adherence...
- Occupational asthma: current concepts in pathogenesis, diagnosis, and managementMark S Dykewicz
Allergy and Immunology Service, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 123:519-28; quiz 529-30. 2009..Preventive and management approaches are reviewed. Longitudinal studies of patients with OA continue to show that timely removal from exposure leads to the best prognosis...
- Tropomyosin: an invertebrate pan-allergenG Reese
Section of Allergy and Clinical Immunology, Tulane University School of Medicine, New Orleans, LA, USA
Int Arch Allergy Immunol 119:247-58. 1999Among food allergens, crustaceans, such as shrimp, crab, crawfish and lobster, are a frequent cause of adverse food reactions in allergic individuals. The major allergen has been identified as the muscle protein tropomyosin...
- Nuclear magnetic resonance structure and IgE epitopes of Blo t 5, a major dust mite allergenSiew Leong Chan
Department of Biological Sciences, National University of Singapore, Singapore, Singapore
J Immunol 181:2586-96. 2008..IgE binding to the group 5 allergen, Blo t 5, is found to be the most prevalent among all B. tropicalis allergens. The NMR structure of Blo t 5 determined represents a novel helical bundle structure consisting of three ..
- In vivo-to-in silico iterations to investigate aeroallergen-host interactionsAlba Llop-Guevara
Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
PLoS ONE 3:e2426. 2008....
- Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergyM Mertens
Department of Dermatology, University of Munster, Von Esmarch Strasse 58, Munster, Germany
Clin Exp Allergy 40:1333-45. 2010..This phenomenon is mainly caused by specific IgE (sIgE) against cross-reactive carbohydrate determinants (CCD). Whether or not these antibodies can induce clinical symptoms is a longstanding debate...
- Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergensEmanuela Corsini
Department of Pharmacological Sciences, Faculty of Pharmacy, Laboratory of Toxicology, University of Milan, Milan, Italy
Toxicol In Vitro 23:789-96. 2009..models, such as the murine local lymph node assay, which does not distinguish between respiratory and contact allergens. Progress in understanding the mechanisms of skin sensitization, provides us with the opportunity to develop in ..
- Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitisGabrielle Pauli
University Hospital, Strasbourg, France
J Allergy Clin Immunol 122:951-60. 2008..Recombinant DNA technology has the potential to produce allergen-specific immunotherapy vaccines with defined composition...
- Characterization and comparison of commercially available mite extracts for in vivo diagnosisB Brunetto
Center for Immunobiologicals Research and Evaluation, Istituto Superiore di Sanita, Rome
Allergy 65:184-90. 2010..This study aimed at evaluating commercially available mite extracts for in vivo diagnosis from eight manufacturers...
- Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cellsShih Chang Hsu
Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
J Biol Chem 285:7903-10. 2010..Similar fucosylated structures are also commonly found in a variety of allergens, but their functional significance remains unclear...
- Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic populationSusanne Krause
Research Center Borstel, Borstel, Germany
J Allergy Clin Immunol 124:771-8.e5. 2009Nonspecific lipid transfer proteins (LTPs) represent potent pollen and food allergens. However, the allergenic properties of peanut LTP have not been studied.
- Atopic sensitization to common allergens without symptoms or signs of airway disorders does not increase exhaled nitric oxideAnnamari Rouhos
Division of Respiratory Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Clin Respir J 2:141-8. 2008..It is, however, unclear whether sensitization to common allergens per se- as verified with positive skin prick tests--affects FENO in healthy individuals.
- Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapyJames N Francis
Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
J Allergy Clin Immunol 111:1255-61. 2003..CONCLUSION: Grass pollen immunotherapy results in a population of circulating T cells that express the IL-10(+) CD4+CD25+ phenotype in response to allergen restimulation...
- Component-resolved in vitro diagnosis of hazelnut allergy in EuropeKirsten Skamstrup Hansen
Allergy Clinic, National University Hospital, Copenhagen, Denmark
J Allergy Clin Immunol 123:1134-41, 1141.e1-3. 2009..Food allergy to hazelnut occurs both with and without concomitant pollen allergy...
- Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanateAdam V Wisnewski
Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
Anal Biochem 400:251-8. 2010..The study also describes new applications of contemporary proteomic methodology for characterizing and standardizing MDI-albumin conjugates destined for use in clinical research...
- Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassayA M Anadón
Laboratorio de Parasitologia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Clin Vaccine Immunol 17:496-502. 2010..of human anisakiasis either are poorly specific or do not include some of the most relevant Anisakis allergens. The use of selected recombinant allergens may improve serodiagnosis...
- Allergenic pollen and pollen allergy in EuropeL Cecchi
Division of Respiratory and Allergic Diseases, Department of Chest Diseases, High Speciality Hospital A Cardarelli Napoli, Italy
Allergy 62:976-90. 2007....
- Non-native Ambrosia pollen in the atmosphere of Rzeszów (SE Poland); evaluation of the effect of weather conditions on daily concentrations and starting dates of the pollen seasonIdalia Kasprzyk
Department of Environmental Biology, University of Rzeszow, Rejtana 16C, Rzeszów 35 959, Poland
Int J Biometeorol 52:341-51. 2008..A close dependence was also found between the starting date of the season and the sum of maximum temperatures and the sum of differences between the maximum and minimum temperatures...
- Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activationNarcy G Arizmendi
Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
J Immunol 186:3164-72. 2011..We hypothesized that PAR(2) activation in the airways by natural allergens with serine proteinase activity plays an important role in allergic sensitization...
- Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergyChristian Radauer
Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
Mol Immunol 48:600-9. 2011..Despite considerable cross-reactivity between these allergens, no correlation between latex-associated plant food allergy and sensitization to hevein or HLDs was found.
- Allergen-related approaches to immunotherapyJennifer M Rolland
Department of Immunology, Monash University, Commercial Road, Melbourne VIC 3004, Australia
Pharmacol Ther 121:273-84. 2009..is restricted, largely due to the risk of serious adverse events, especially in asthmatics and for potent allergens such as peanut, seafood and latex...
- Microarrayed allergen molecules for the diagnosis of allergic diseasesAdriano Mari
Center for Molecular Allergology, IDI IRCCS, Via dei Monti di Creta 104, Rome, Italy
Curr Allergy Asthma Rep 10:357-64. 2010..During the past 30 years, knowledge of the molecular structure of allergens has increased dramatically, and the characterization and production of allergenic molecules, as natural purified ..
- T cell-specific T-box transcription factor haplotype is associated with allergic asthma in childrenMonica Cheng Munthe-Kaas
Department of Paediatrics, Ulleval University Hospital, Oslo, Norway
J Allergy Clin Immunol 121:51-6. 2008..Asthma and allergy are common complex diseases characterized by T(H)2-mediated inflammation...
- Interactions of airway epithelium with protease allergens in the allergic responseA Jacquet
Department of Medicine, Division of Allergy and Clinical Immunology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand
Clin Exp Allergy 41:305-11. 2011..This review will summarize insights into the interactions of protease allergens with the respiratory epithelium...
- The role of dendritic and epithelial cells as master regulators of allergic airway inflammationBart N Lambrecht
Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium
Lancet 376:835-43. 2010Lung dendritic cells bridge innate and adaptive immunity, integrating a variety of stimuli from allergens, microbial colonisation, environmental pollution, and innate immune cells into a signal for T lymphocytes of the adaptive immune ..
- Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing propertiesJean Pierre Allam
Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
J Allergy Clin Immunol 126:638-45.e1. 2010..Oral mucosal Langerhans cells (oLCs) play a central role. However, little is known about allergen binding by oLCs during mucosal allergen resorption and its impact on oLC functions...
- Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergenR D'Avino
Institute of Protein Biochemistry, CNR, Naples, Italy
Allergy 66:870-7. 2011..Kiwifruit is an important cause of food allergy. A high amount of a protein with a molecular mass compatible with that of Bet v 1 was observed in the kiwifruit extract...
- Isoform identification and characterization of Art v 3, the lipid-transfer protein of mugwort pollenGabriele Gadermaier
Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
Mol Immunol 46:1919-24. 2009..The newly identified sequences provide the basis for recombinant mugwort LTP production enabling batch-to-batch reproducibility and thus ensuring high-quality products for diagnosis and therapy...
- House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epitheliumIrene H Heijink
Department of Allergology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
Am J Respir Cell Mol Biol 42:69-79. 2010..We propose that TGF-beta secretion and dysregulated EGFR signaling may increase epithelial vulnerability to allergens and trigger the induction of EMT, a hitherto unrecognized contributor to airway remodeling in asthma.
- Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacyAnaïs Pipet
INSERM U 915, l institut du thorax, 1 rue Gaston Veil, Nantes F 44000, France
Respir Med 103:800-12. 2009..Most recently sublingual tablets were proposed in allergic rhinitis. This paper reviews the mechanisms of SIT, the evidence of efficacy of SIT from the injective to the sublingual route and reminds the current guidelines...
- Towards a cure for food allergyJustin M Skripak
Mount Sinai School of Medicine, New York, NY, United States
Curr Opin Immunol 20:690-6. 2008..Allergen non-specific approaches include biologics to suppress free total IgE levels (e.g. anti-IgE antibody) or to induce more general immune suppression (Chinese herbal medication)...
- Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergensM Lombardero
Dept I D, ALK Abelló SA, Madrid, Spain
Clin Exp Allergy 34:1415-21. 2004Artemisia vulgaris is a widespread weed in the Mediterranean area and several allergens have been detected in its pollen...
- Development of a peptide reactivity assay for screening contact allergensG Frank Gerberick
Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45253 8707, USA
Toxicol Sci 81:332-43. 2004..The majority of chemical allergens is electrophilic and as such reacts with nucleophilic amino acids like cysteine or lysine...
- Quantitative measurement of IgE antibodies to purified allergens using streptavidin linked to a high-capacity solid phaseElizabeth A Erwin
University of Virginia Astma and Allergic Diseases Center, Charlottesville, VA 22908-1355, USA
J Allergy Clin Immunol 115:1029-35. 2005..units per milliliter for many allergen extracts, but this is not easily achieved with purified or novel allergens. OBJECTIVE: To develop assays for IgE antibody suitable for purified or novel allergens by using a commercially ..
- Climate change, air quality, and human healthPatrick L Kinney
Department of Environmental Health Sciences, Mailman School of Public Health at Columbia University, New York, New York 10032, USA
Am J Prev Med 35:459-67. 2008..Based on the observed and anticipated impacts, adaptation strategies and research needs are discussed...
- Allergen databases: current status and perspectivesAdriano Mari
Center for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
Curr Allergy Asthma Rep 9:376-83. 2009..on allergenic molecules have been published during the past 20 years, and the number of proteins reported as allergens is close to 1500 (http://www.allergome.org)...
- Air pollution and allergic diseaseHaejin Kim
Department of Internal Medicine, University of Cincinnati College of Medicine, OH 45267 0563, USA
Curr Allergy Asthma Rep 9:128-33. 2009..Health care providers and the general community should also support public policy designed to improve outdoor air quality by developing programs that provide incentives for industry to comply with controlling pollution emissions...
- Characterisation of major peptides in 'jack jumper' ant venom by mass spectrometryNoel W Davies
Central Science Laboratory, University of Tasmania, Private Bag 74, Hobart 7001, Tasmania, Australia
Toxicon 43:173-83. 2004..Further IgE-binding studies using these peptides are warranted and a revision of the nomenclature of allergenic components of M. pilosula venom may be required to conform with established IUIS guidelines...
- Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of ageMartin Penagos
Division of Allergy and Respiratory Diseases, Department of Internal, edicine, University of Genoa, Genoa, Italy
Chest 133:599-609. 2008..We evaluated the efficacy of SLIT in the treatment of allergic asthma in children by a metaanalysis of randomized, double-blind, and placebo-controlled (DBPC) clinical trials...
- The ACVD task force on canine atopic dermatitis (IV): environmental allergensP B Hill
Department of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Edinburgh EH25 9RG, Scotland, UK
Vet Immunol Immunopathol 81:169-86. 2001Numerous environmental allergens have been incriminated in the pathogenesis of canine atopic dermatitis (AD)...
- Allergens are distributed into few protein families and possess a restricted number of biochemical functionsChristian Radauer
Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
J Allergy Clin Immunol 121:847-52.e7. 2008Existing allergen databases classify their entries by source and route of exposure, thus lacking an evolutionary, structural, and functional classification of allergens.
- Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adultsMeri K Tulic
Meakins Christie Laboratories, Notre Dame Hospital and Institut ORL de Montréal, Montreal, Quebec, Canada
Lancet 363:1689-97. 2004..We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults...
- IgE cross-reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1N Acevedo
Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
Allergy 64:1635-43. 2009..The objective of this study was to investigate immunoglobulin E (IgE) cross-reactivity between Ascaris and two domestic mites in the tropics...
- Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosisR Crameri
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Int Immunol 10:1211-6. 1998..We have cloned A. fumigatus allergens from a cDNA library displayed on phage surface, sequenced the inserts and produced recombinant proteins in ..
- Roasted hazelnuts--allergenic activity evaluated by double-blind, placebo-controlled food challengeK Skamstrup Hansen
Allergy Clinic, Department 7551, National University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
Allergy 58:132-8. 2003..Immunoblotting experiments with recombinant hazelnut allergens showed sensitization against Cor a 1.04 in 16/17 patients and against Cor a 2 in 7/17 patients...
- Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responsesA J Coyle
Department of Biology, Inflammation Division, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
J Exp Med 190:895-902. 1999..Taken together, our data demonstrate an important role of T1/ST2 in Th2-mediated inflammatory responses and suggest that T1/ST2 may prove to be a novel target for the selective suppression of Th2 immune responses...
- House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cellsHamida Hammad
Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Medicine, Ghent University, Ghent, Belgium
Nat Med 15:410-6. 2009..Our data identify an innate immune function of airway epithelial cells that drives allergic inflammation via activation of mucosal DCs...
- Multiple microbial exposures in the home may protect against asthma or allergy in childhoodJ E Sordillo
Channing Laboratory, Boston, MA, USA
Clin Exp Allergy 40:902-10. 2010....
- Lipid transfer proteins from Rosaceae fruits share consensus epitopes responsible for their IgE-binding cross-reactivityJean Philippe Borges
Surfaces Cellulaires et Signalisation chez les Végétaux, UMR Université Paul Sabatier CNRS 5546, 24 Chemin de Borde Rouge, 31326 Castanet Tolosan, France
Biochem Biophys Res Commun 365:685-90. 2008..have been characterized that cover a large area (40%) of the molecular surface of lipid transfer protein allergens of Rosaceae (apple, peach, apricot, and plum)...
- Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lungChristina C Lewis
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 123:795-804.e8. 2009..Although these 2 cytokines share signaling components, the molecular mechanisms by which they mediate different phases of the allergic asthmatic response remain elusive...
- Allergen specific immunotherapy for atopic dermatitisNatalija Novak
Department of Dermatology, University of Bonn, Bonn, Germany
Curr Opin Allergy Clin Immunol 7:542-46. 2007..To describe recent developments as well as the pros and cons of allergen specific immunotherapy as a putative therapeutic option for a subgroup of patients with atopic dermatitis...
- Pathogenesis of atopic dermatitis: new developmentsThomas Bieber
Department of Dermatology and Allergy, Rheinische Friedrich Wilhelms University Bonn, Bonn, Germany
Curr Allergy Asthma Rep 9:291-4. 2009..This review aims to summarize the most recent findings in this field...
- Development of a novel peptide microarray for large-scale epitope mapping of food allergensJing Lin
Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
J Allergy Clin Immunol 124:315-22, 322.e1-3. 2009..The peptide microarray is a novel assay that facilitates high-throughput screening of peptides with a small quantity of sample...
- Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2Hideaki Kouzaki
Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 183:1427-34. 2009..models suggest roles for protease(s) in Th2-type immune responses, we hypothesized that proteases from airborne allergens may induce TSLP production in a human airway epithelial cell line, BEAS-2B...
- Epidemiology of anaphylaxisMimi L K Tang
Department of Allergy and Immunology, Royal Children s Hospital, Melbourne, Australia
Curr Opin Allergy Clin Immunol 9:351-6. 2009..This review examines recent developments in the epidemiology of anaphylaxis, focusing on new information that may assist in identifying those at increased risk of severe reactions and adverse outcomes...
- Elevated peripheral allergen-specific T cell response is crucial for a positive atopy patch test reactionCatharina Johansson
Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital, Stockholm SE 171, Sweden
Int Arch Allergy Immunol 150:51-8. 2009..Here we investigate the relationship between APT reactions and allergen-specific peripheral IgE and T cell reactivity in atopic eczema patients...
- Causes of food-induced anaphylaxis in Italian adults: a multi-centre studyR Asero
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
Int Arch Allergy Immunol 150:271-7. 2009Data about food-induced anaphylaxis in Italy are missing. Objective: It was the aim of this study to detect the main foods/food allergens causing anaphylaxis in Italy.
- Latex allergy: a model for therapyJ M Rolland
Department of Immunology, Monash University, Melbourne, Vic, Australia
Clin Exp Allergy 38:898-912. 2008..Subjects with fruit and vegetable allergy are also at risk due to cross-reactive allergens. Following the significant advances in the identification and characterization of common aeroallergens, latex ..
- Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthmaFrank Kirstein
Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Health Sciences Faculty, University of Cape Town and International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa
J Allergy Clin Immunol 126:347-54. 2010..In vitro studies have suggested that IL-4 receptor alpha (IL-4Ralpha) signaling on smooth muscle cells is critical for airway inflammation and airway hyperresponsiveness...
- GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in EuropeL M Heinzerling
Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
Allergy 64:1498-506. 2009..Thus, it has been difficult to compare results from different centres or studies across Europe. It was, therefore, crucial to standardize and harmonize procedures in allergy diagnosis and treatment within Europe...
- Prolonged eosinophil production after allergen exposure in IFN-gammaR KO mice is IL-5 dependentL L Zhao
Lung Pharmacology Group, Department of Internal Medicine Respiratory and Allergology, The Sahlgrenska Academy, Goteborg University, Gothenburg, Sweden
Scand J Immunol 67:480-8. 2008..In this model of a Th2-driven prolonged allergic eosinophilia, new eosinophils contribute to the extended inflammation in the airways by enhanced BM eosinophilopoiesis in an IL-5-dependent manner...
- Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-beta expressionCharles Pilette
Upper Respiratory Medicine, Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, U K
J Immunol 178:4658-66. 2007....
- Recombinant allergens for immunotherapyRudolf Valenta
Christian Doppler Laboratory for Allergy Research, Division of Immunopathology, Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
J Allergy Clin Immunol 119:826-30. 2007Recombinant allergens can be produced as defined molecules in consistent quality and unlimited amounts according to the corresponding DNA template...
- Gal d 6 is the second allergen characterized from egg yolkAlvaro Amo
Department of Allergology, Complejo Asistencial, Avda del Cid, Burgos, Spain
J Agric Food Chem 58:7453-7. 2010..Thus, a second egg yolk allergen has been described and designated Gal d 6 by the World Health Organization (WHO)/International Union of Immunological Societies (IUIS) Allergen Nomenclature Subcommittee...
- Contact allergy to allergens of the TRUE-test (panels 1 and 2) has decreased modestly in the general populationJ P Thyssen
National Allergy Research Centre, Department of Dermato Allergology, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark
Br J Dermatol 161:1124-9. 2009..The prevalence of contact allergy in the general population is nearly 20%...
- Characterization of peach thaumatin-like proteins and their identification as major peach allergensA Palacin
Unidad de Bioquimica, Departamento de Biotecnologia, E T S Ingenieros Agronomos, UPM, Madrid, Spain
Clin Exp Allergy 40:1422-30. 2010..However, the involvement of other allergenic families cannot be ruled out. Thaumatin-like proteins (TLPs) have been described as food allergen in several fruits, such as apple, cherry, kiwi and banana, and pollen...
- The panel of egg allergens, Gal d 1-Gal d 5: Their improved purification and characterizationBenedikte Jacobsen
DTU BioSys, Technical University of Denmark, Lyngby, Denmark
Mol Nutr Food Res 52:S176-85. 2008..Although the egg white allergens Gal d 1, 2, 3 and 4 (ovomucoid, ovalbumin, ovotransferrin, and lysozyme) are commercially available, these ..
- Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory studyLouis J Vaickus
Boston University School of Medicine, Department of Pathology and Laboratory Medicine, Boston, MA, USA
Respir Res 11:160. 2010..In this study we endeavored to induce oral tolerance to cockroach allergen (CRA: a complex mixture of insect components) in order to ameliorate asthma-like, allergic pulmonary inflammation...
- Airway house dust extract exposures modify allergen-induced airway hypersensitivity responses by TLR4-dependent and independent pathwaysDiane Lam
Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
J Immunol 181:2925-32. 2008....
- Skin prick test reactivity to common allergens among women in Entebbe, UgandaHarriet Mpairwe
MRC UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute, P O Box 49, Entebbe, Uganda
Trans R Soc Trop Med Hyg 102:367-73. 2008..14, 95% CI 0.03-0.69); women with a history of asthma were less likely to have hookworm (adjusted odds ratio 0.24, 95% CI 0.07-0.81) but this association was weaker for women with a history of eczema. [Clinical Trial No. ISRCTN32849447]...
- A draining lymph node assay (DLNA) for assessing the sensitizing potential of proteinsDarrell R Boverhof
Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
Toxicol Lett 193:144-51. 2010..These data illustrate both the opportunities and challenges associated with the examination of the draining lymph node proliferative response to assess the allergenic potential of proteins...
- Treatment of established asthma in a murine model using CpG oligodeoxynucleotidesJoel N Kline
Department of Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Am J Physiol Lung Cell Mol Physiol 283:L170-9. 2002..Unlike previous studies, these data demonstrate that the combination of CpG ODN and allergen can effectively reverse established atopic eosinophilic airway disease, at least partially through redirecting a Th2 to a Th1 response...
- Mechanisms of allergen-specific immunotherapy: T-regulatory cells and moreJohan Verhagen
Swiss Institute of Allergy and Asthma Research (SIAF, Obere Strasse 22, CH-7270 Davos, Switzerland
Immunol Allergy Clin North Am 26:207-31, vi. 2006..effector T cells to a Treg-cell phenotype seems to be crucial in maintaining a healthy immune response to allergens and successful allergen-specific immunotherapy...
- Performance evaluation of a specific IgE assay developed for the ADVIA centaur immunoassay systemAnita Birgit Petersen
In Vitro Diagnostics Business Unit, ALK ABELLO, Denmark
Clin Biochem 37:882-92. 2004..To develop and evaluate a liquid phase immunoassay for accurate determination of allergen-specific IgE (sIgE) as a useful tool in the diagnosis of allergy patients...
- Use of acetaminophen and the risk of self-reported allergic symptoms and skin sensitization in Butajira, EthiopiaGail Davey
Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia
J Allergy Clin Immunol 116:863-8. 2005..Studies in developed countries suggest that acetaminophen use is associated with increased risk of asthma, but it is unclear whether this association is causal...
- Evaluation of risk factors in patients diagnosed with bronchial asthmaM Reha Cengizlier
Department of Allergy, Ministry of Health, Ankara Diskapi Children's Diseases Training and Research Hospital, Ankara, Turkey
Allergol Immunopathol (Madr) 34:4-9. 2006..9% of the patients were atopic on the skin prick test. RESULTS: Asthma seems to be an important health problem in our country. Recognizing the risk factors is important for the diagnosis and prevention of the disease...
- Allergy to kiwi in patients with baker's asthma: identification of potential cross-reactive allergensArantxa Palacin
Unidad de Bioquimica, Departamento de Biotecnologia, E T S Ingenieros Agronomos, UPM, Madrid, Spain
Ann Allergy Asthma Immunol 101:200-5. 2008..Allergy to kiwifruit has being increasingly reported in the past few years. No association between both allergic disorders has been described so far...
- [Allergies and hypersensibility in childhood and adult]Gisele Kanny
EA 3999 maladies allergiques diagnostic et thérapeutique, Allergologie et Immunologie Clinique, Centre Hospitalier Universitaire, Hopital Central, 54035 Nancy Cedex
Rev Prat 57:1129-37. 2007
- [Allergy-related hypereosinophilia]Gilles Garcia
Service des Explorations Fonctionnelles Respiratoires, Hopital Antoine Beclere, Clamart
Presse Med 35:135-43. 2006..Atopy is diagnosed primarily by cutaneous skin-prick tests and the new multi-allergen blood test. A diagnosis of allergy requires the presence of symptoms and justifies workups for asthma, rhinitis, food allergies, or atopic dermatitis...
- Differentiation of IgE-dependent and IgE-independent reactions in children with bronchial asthma on the basis of TOP CAST Paediatric Allergen Mix testD Korol
Department of Paediatric Allergology, Medical University of Białystok, Children Clinical Hospital, Ul Waszyngtona 17, 15 274 Białystok, Poland
Adv Med Sci 51:232-6. 2006..in vitro test based on evaluation of leukotrienes synthesised by basophils under the influence of specific allergens. The aim of the study was evaluation of applicability of this test as screening examination in diagnosis of ..
- Date palm pollen allergoid: characterization of its chemical-physical and immunological propertiesG Mistrello
Lofarma S p A, Milan, Italy
Int Arch Allergy Immunol 145:224-30. 2008....
- Host Defense Mechanisms in Chronic Lung DiseaseJo Rae Wright; Fiscal Year: 2007..with cells of both the adaptive and innate immune systems to coordinately maximize defense against inhaled allergens and that cause and exacerbate asthma, while minimizing an over exuberant immune response that could result in ..
- Mapping for Specialized Domains for FCeRI Signaling & InternalizationBridget S Wilson; Fiscal Year: 2010By crosslinking IgE bound to the high affinity IgE receptor, FceRI, allergens initiate a complex sequence of events leading to release of mast cell inflammatory mediators...
- ASTHMA AND ALLERGIC DISEASE CENTERThomas Platts Mills; Fiscal Year: 2007..These studies have provided extensive evidence about effects of chronic exposure to indoor allergens, as well as the relevance of viruses to acute episodes in the hospital; the role of chronic sinus disease; and ..
- Therapeutic Strategies for Environmental Lung DiseasesJames Bonner; Fiscal Year: 2007..asthma or interstitial pulmonary fibrosis that result from environmental exposures to a wide variety of inhaled allergens and toxicants...
- Diesel, Allergens and Gene Interaction and Child AtopyGrace LeMasters; Fiscal Year: 2009....
- OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSINGThomas Robins; Fiscal Year: 2001..spirometry and methacholine challenge tests, skin prick tests (for common aeroallergens and specific seafood allergens) and skin patch testing...
- Health Effects of CREON2000 In Asthmatic ChildrenMark Glazman; Fiscal Year: 2003DESCRIPTION: (provided by applicant): Indoor allergens including molds and bacterial byproducts (e.g., endotoxin) have the potential to act as protective agents versus allergens capable of sensitizing and causing allergies and asthma...
- UVA Asthma and Allergic Diseases CenterThomas Platts Mills; Fiscal Year: 2005..objective of research at the University of Virginia has been to understand the role of foreign antigens or allergens in causing and maintaining the chronic inflammation of asthma...
- Soy Immunotherapy for Patients with Peanut AnaphylaxisARVIL BURKS; Fiscal Year: 2004..idea that the storage proteins in soybeans would share enough amino acid homology with the respective peanut allergens to down regulate peanut-specific T cells, we have utilized soybean protein IT in a peanut allergic mouse model ..
- Rapid Test for Monitoring Dust Mite Avoidance in HomesMartin Chapman; Fiscal Year: 2004b>Allergens found in the home derived from dust mites, animal dander, cockroaches and fungi are commonly associated with the development of asthma...
- Socio-Cultural Influences on Allergic SensitizationGinger Chew; Fiscal Year: 2006..In addition, we understand that housing factors influence levels of indoor allergens, such that poor housing lends rise to cockroach and mouse allergens, and high humidity is associated with high ..
- Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic AsthmaShyam Mohapatra; Fiscal Year: 2006..Deviation of immune response to allergens from a pathogenic T helper-2 type response to T helper-1 type may provide a practical approach to modifying the ..
- DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMAThomas Platts Mills; Fiscal Year: 2009..By contrast, exposure to dust mite, cockroach or pollen allergens can induce sufficient IgE ab to make an important contribution to total serum IgE...
- DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMAThomas A Platts Mills; Fiscal Year: 2010..By contrast, exposure to dust mite, cockroach or pollen allergens can induce sufficient IgE ab to make an important contribution to total serum IgE...
- DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMAThomas Platts Mills; Fiscal Year: 1992The objective of these studies is to improve understanding of the role that indoor allergens play in asthma and to establish effective regimes for treating the disease by reducing exposure to allergens in homes...
- The Epidemiology of Home Allergens and AsthmaDiane R Gold; Fiscal Year: 2010Asthma is the most common disease of childhood in the United States. The role of microbial flora and allergens in asthma development is poorly understood...
- Early Life Exposure to Microbial Products and AsthmaJoel Kline; Fiscal Year: 2005..According to this paradigm, microbial exposures inhibit the development of Th2-skewed responses to environmental allergens, putatively through the induction of Th1 and/or regulatory-type responses...
- The Epidemiology of Home Allergens and AsthmaDiane Gold; Fiscal Year: 2009Asthma is the most common disease of childhood in the United States. The role of microbial flora and allergens in asthma development is poorly understood...