allergens

Summary

Summary: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

Top Publications

  1. ncbi The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
  2. ncbi A mechanism for the initiation of allergen-induced T helper type 2 responses
    Caroline L Sokol
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connceticut 06510, USA
    Nat Immunol 9:310-8. 2008
  3. ncbi Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    Aurelien Trompette
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 457:585-8. 2009
  4. ncbi Allergen-specific immunotherapy with recombinant grass pollen allergens
    Marek Jutel
    Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland
    J Allergy Clin Immunol 116:608-13. 2005
  5. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
  6. ncbi Loosening of plant cell walls by expansins
    D J Cosgrove
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Nature 407:321-6. 2000
  7. ncbi Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009
  8. ncbi Immunological mechanisms of allergen-specific immunotherapy
    Mark Larché
    Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Nat Rev Immunol 6:761-71. 2006
  9. ncbi The asthma epidemic
    Waltraud Eder
    University Children's Hospital, Munich, Germany
    N Engl J Med 355:2226-35. 2006
  10. ncbi Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study
    T Platts-Mills
    University of Virginia Asthma and Allergic Diseases Center, University of Virginia Department of Medicine, Charlottesville, USA
    Lancet 357:752-6. 2001

Research Grants

  1. Host Defense Mechanisms in Chronic Lung Disease
    Jo Rae Wright; Fiscal Year: 2007
  2. Mapping for Specialized Domains for FCeRI Signaling & Internalization
    Bridget S Wilson; Fiscal Year: 2010
  3. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
  4. Therapeutic Strategies for Environmental Lung Diseases
    James Bonner; Fiscal Year: 2007
  5. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
  6. OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSING
    Thomas Robins; Fiscal Year: 2001
  7. Health Effects of CREON2000 In Asthmatic Children
    Mark Glazman; Fiscal Year: 2003
  8. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
  9. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
  10. Rapid Test for Monitoring Dust Mite Avoidance in Homes
    Martin Chapman; Fiscal Year: 2004

Detail Information

Publications304 found, 100 shown here

  1. ncbi The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
    ..In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic ..
  2. ncbi A mechanism for the initiation of allergen-induced T helper type 2 responses
    Caroline L Sokol
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connceticut 06510, USA
    Nat Immunol 9:310-8. 2008
    Both metazoan parasites and simple protein allergens induce T helper type 2 (TH2) immune responses, but the mechanisms by which the innate immune system senses these stimuli are unknown...
  3. ncbi Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    Aurelien Trompette
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nature 457:585-8. 2009
    ..Why particular proteins tend to act as allergens in susceptible hosts is a fundamental mechanistic question that remains largely unanswered...
  4. ncbi Allergen-specific immunotherapy with recombinant grass pollen allergens
    Marek Jutel
    Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland
    J Allergy Clin Immunol 116:608-13. 2005
    ..Recombinant DNA technology has enabled the cloning of many allergens, thus facilitating investigations aimed at improving efficacy and safety of immunotherapy.
  5. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
    The regulation of normal and allergic immune responses to airborne allergens in the mucosa is still poorly understood, and the mechanism of specific immunotherapy (SIT) in normalizing the allergic response to such allergens is currently ..
  6. ncbi Loosening of plant cell walls by expansins
    D J Cosgrove
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Nature 407:321-6. 2000
    ..Expansin's action has puzzling implications for plant cell-wall structure. The recent explosion of gene sequences and expression data has given new hints of additional biological functions for expansins...
  7. ncbi Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    J Allergy Clin Immunol 123:735-46; quiz 747-8. 2009
    ..Their identification as key regulators of immunologic processes in peripheral tolerance to allergens has opened an important era in the prevention and treatment of allergic diseases...
  8. ncbi Immunological mechanisms of allergen-specific immunotherapy
    Mark Larché
    Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Nat Rev Immunol 6:761-71. 2006
    ..Approaches to address this problem include the use of modified allergens, novel adjuvants and alternative routes of administration...
  9. ncbi The asthma epidemic
    Waltraud Eder
    University Children's Hospital, Munich, Germany
    N Engl J Med 355:2226-35. 2006
  10. ncbi Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study
    T Platts-Mills
    University of Virginia Asthma and Allergic Diseases Center, University of Virginia Department of Medicine, Charlottesville, USA
    Lancet 357:752-6. 2001
    Although asthma is strongly associated with immediate hypersensitivity to indoor allergens, several studies have suggested that a cat in the house can decrease the risk of asthma...
  11. ncbi Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection system
    E Scala
    Centre for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
    Clin Exp Allergy 40:911-21. 2010
    ..This can be carried out applying the test in the routine diagnostic work-up...
  12. ncbi Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study
    T Werfel
    Department of Dermatology and Allergology, Hannover Medical School, Hannover, Germany
    Allergy 61:202-5. 2006
    ..is able to improve the eczema in patients with atopic dermatitis who are sensitized to house dust mite allergens and reduces the need for topical corticosteroids...
  13. ncbi The role of protein glycosylation in allergy
    Friedrich Altmann
    Divison of Biochemistry, Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    Int Arch Allergy Immunol 142:99-115. 2007
    ..and suppress anti-CCD IgE without interference from peptide epitopes can be best met by artificial glycoprotein allergens. Hydroxyproline-linked arabinose (single beta-arabinofuranosyl residues) has been identified as a new IgE-..
  14. ncbi Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
    William C Nierman
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 438:1151-6. 2005
    ..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus...
  15. ncbi Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach
    G Frank Gerberick
    The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45252, USA
    Toxicol Sci 97:417-27. 2007
    ..One unifying characteristic of chemical allergens is the requirement that they react with proteins for the effective induction of skin sensitization...
  16. ncbi The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity
    Pierre Joseph Royer
    School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, United Kingdom
    J Immunol 185:1522-31. 2010
    ..We have investigated the ability of MR to recognize glycosylated allergens. Using a gene silencing strategy, we have specifically inhibited the expression of MR on human monocyte-derived ..
  17. ncbi Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family
    Iain W Chalmers
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Genomics 9:89. 2008
    ..protein/Tpx-1/Ag5/PR-1/Sc7 (SCP/TAPS) domain is found across phyla and is a major structural feature of insect allergens, mammalian sperm proteins and parasitic nematode secreted molecules...
  18. ncbi Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
    Eleanor M Ling
    Department of Allergy, National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
    Lancet 363:608-15. 2004
    ..Allergic diseases are frequent and rising in prevalence, and result from activation of T-helper (Th) 2 cells by allergens. CD4+CD25+ regulatory T cells suppress T-cell activation in vitro and prevent pathological findings in animal ..
  19. ncbi Role of interleukin 10 in specific immunotherapy
    C A Akdis
    Swiss Institute of Allergy and Asthma Research, CH 7270 Davos, Switzerland
    J Clin Invest 102:98-106. 1998
    ..Accordingly, increased IL-10 production by SIT causes specific anergy in peripheral T cells, and regulates specific IgE and IgG4 production toward normal IgG4-related immunity...
  20. ncbi A mouse model for food allergy using intraperitoneal sensitization
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Methods 41:91-8. 2007
    ..most foreign proteins are immunogenic (able to induce IgG antibody responses), relatively few are important food allergens with the capacity to provoke IgE antibody production...
  21. ncbi Noninjection routes for immunotherapy
    Giorgio Walter Canonica
    Division of Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    J Allergy Clin Immunol 111:437-48; quiz 449. 2003
    ..Although the long-lasting efficacy has been recently documented for the sublingual route, several points still need to be elucidated, including mechanisms of action, optimal dosage, cost-effectiveness, and adherence...
  22. ncbi Occupational asthma: current concepts in pathogenesis, diagnosis, and management
    Mark S Dykewicz
    Allergy and Immunology Service, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 123:519-28; quiz 529-30. 2009
    ..Preventive and management approaches are reviewed. Longitudinal studies of patients with OA continue to show that timely removal from exposure leads to the best prognosis...
  23. ncbi Tropomyosin: an invertebrate pan-allergen
    G Reese
    Section of Allergy and Clinical Immunology, Tulane University School of Medicine, New Orleans, LA, USA
    Int Arch Allergy Immunol 119:247-58. 1999
    Among food allergens, crustaceans, such as shrimp, crab, crawfish and lobster, are a frequent cause of adverse food reactions in allergic individuals. The major allergen has been identified as the muscle protein tropomyosin...
  24. ncbi Nuclear magnetic resonance structure and IgE epitopes of Blo t 5, a major dust mite allergen
    Siew Leong Chan
    Department of Biological Sciences, National University of Singapore, Singapore, Singapore
    J Immunol 181:2586-96. 2008
    ..IgE binding to the group 5 allergen, Blo t 5, is found to be the most prevalent among all B. tropicalis allergens. The NMR structure of Blo t 5 determined represents a novel helical bundle structure consisting of three ..
  25. ncbi In vivo-to-in silico iterations to investigate aeroallergen-host interactions
    Alba Llop-Guevara
    Department of Pathology and Molecular Medicine, Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 3:e2426. 2008
    ....
  26. ncbi Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergy
    M Mertens
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Clin Exp Allergy 40:1333-45. 2010
    ..This phenomenon is mainly caused by specific IgE (sIgE) against cross-reactive carbohydrate determinants (CCD). Whether or not these antibodies can induce clinical symptoms is a longstanding debate...
  27. ncbi Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens
    Emanuela Corsini
    Department of Pharmacological Sciences, Faculty of Pharmacy, Laboratory of Toxicology, University of Milan, Milan, Italy
    Toxicol In Vitro 23:789-96. 2009
    ..models, such as the murine local lymph node assay, which does not distinguish between respiratory and contact allergens. Progress in understanding the mechanisms of skin sensitization, provides us with the opportunity to develop in ..
  28. ncbi Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis
    Gabrielle Pauli
    University Hospital, Strasbourg, France
    J Allergy Clin Immunol 122:951-60. 2008
    ..Recombinant DNA technology has the potential to produce allergen-specific immunotherapy vaccines with defined composition...
  29. ncbi Characterization and comparison of commercially available mite extracts for in vivo diagnosis
    B Brunetto
    Center for Immunobiologicals Research and Evaluation, Istituto Superiore di Sanita, Rome
    Allergy 65:184-90. 2010
    ..This study aimed at evaluating commercially available mite extracts for in vivo diagnosis from eight manufacturers...
  30. ncbi Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells
    Shih Chang Hsu
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Biol Chem 285:7903-10. 2010
    ..Similar fucosylated structures are also commonly found in a variety of allergens, but their functional significance remains unclear...
  31. ncbi Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population
    Susanne Krause
    Research Center Borstel, Borstel, Germany
    J Allergy Clin Immunol 124:771-8.e5. 2009
    Nonspecific lipid transfer proteins (LTPs) represent potent pollen and food allergens. However, the allergenic properties of peanut LTP have not been studied.
  32. ncbi Atopic sensitization to common allergens without symptoms or signs of airway disorders does not increase exhaled nitric oxide
    Annamari Rouhos
    Division of Respiratory Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Clin Respir J 2:141-8. 2008
    ..It is, however, unclear whether sensitization to common allergens per se- as verified with positive skin prick tests--affects FENO in healthy individuals.
  33. ncbi Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy
    James N Francis
    Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    J Allergy Clin Immunol 111:1255-61. 2003
    ..CONCLUSION: Grass pollen immunotherapy results in a population of circulating T cells that express the IL-10(+) CD4+CD25+ phenotype in response to allergen restimulation...
  34. ncbi Component-resolved in vitro diagnosis of hazelnut allergy in Europe
    Kirsten Skamstrup Hansen
    Allergy Clinic, National University Hospital, Copenhagen, Denmark
    J Allergy Clin Immunol 123:1134-41, 1141.e1-3. 2009
    ..Food allergy to hazelnut occurs both with and without concomitant pollen allergy...
  35. ncbi Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate
    Adam V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    Anal Biochem 400:251-8. 2010
    ..The study also describes new applications of contemporary proteomic methodology for characterizing and standardizing MDI-albumin conjugates destined for use in clinical research...
  36. ncbi Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay
    A M Anadón
    Laboratorio de Parasitologia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Clin Vaccine Immunol 17:496-502. 2010
    ..of human anisakiasis either are poorly specific or do not include some of the most relevant Anisakis allergens. The use of selected recombinant allergens may improve serodiagnosis...
  37. ncbi Allergenic pollen and pollen allergy in Europe
    L Cecchi
    Division of Respiratory and Allergic Diseases, Department of Chest Diseases, High Speciality Hospital A Cardarelli Napoli, Italy
    Allergy 62:976-90. 2007
    ....
  38. ncbi Non-native Ambrosia pollen in the atmosphere of Rzeszów (SE Poland); evaluation of the effect of weather conditions on daily concentrations and starting dates of the pollen season
    Idalia Kasprzyk
    Department of Environmental Biology, University of Rzeszow, Rejtana 16C, Rzeszów 35 959, Poland
    Int J Biometeorol 52:341-51. 2008
    ..A close dependence was also found between the starting date of the season and the sum of maximum temperatures and the sum of differences between the maximum and minimum temperatures...
  39. ncbi Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation
    Narcy G Arizmendi
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 186:3164-72. 2011
    ..We hypothesized that PAR(2) activation in the airways by natural allergens with serine proteinase activity plays an important role in allergic sensitization...
  40. ncbi Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy
    Christian Radauer
    Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Mol Immunol 48:600-9. 2011
    ..Despite considerable cross-reactivity between these allergens, no correlation between latex-associated plant food allergy and sensitization to hevein or HLDs was found.
  41. ncbi Allergen-related approaches to immunotherapy
    Jennifer M Rolland
    Department of Immunology, Monash University, Commercial Road, Melbourne VIC 3004, Australia
    Pharmacol Ther 121:273-84. 2009
    ..is restricted, largely due to the risk of serious adverse events, especially in asthmatics and for potent allergens such as peanut, seafood and latex...
  42. ncbi Microarrayed allergen molecules for the diagnosis of allergic diseases
    Adriano Mari
    Center for Molecular Allergology, IDI IRCCS, Via dei Monti di Creta 104, Rome, Italy
    Curr Allergy Asthma Rep 10:357-64. 2010
    ..During the past 30 years, knowledge of the molecular structure of allergens has increased dramatically, and the characterization and production of allergenic molecules, as natural purified ..
  43. ncbi T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children
    Monica Cheng Munthe-Kaas
    Department of Paediatrics, Ulleval University Hospital, Oslo, Norway
    J Allergy Clin Immunol 121:51-6. 2008
    ..Asthma and allergy are common complex diseases characterized by T(H)2-mediated inflammation...
  44. ncbi Interactions of airway epithelium with protease allergens in the allergic response
    A Jacquet
    Department of Medicine, Division of Allergy and Clinical Immunology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand
    Clin Exp Allergy 41:305-11. 2011
    ..This review will summarize insights into the interactions of protease allergens with the respiratory epithelium...
  45. ncbi The role of dendritic and epithelial cells as master regulators of allergic airway inflammation
    Bart N Lambrecht
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium
    Lancet 376:835-43. 2010
    Lung dendritic cells bridge innate and adaptive immunity, integrating a variety of stimuli from allergens, microbial colonisation, environmental pollution, and innate immune cells into a signal for T lymphocytes of the adaptive immune ..
  46. ncbi Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 126:638-45.e1. 2010
    ..Oral mucosal Langerhans cells (oLCs) play a central role. However, little is known about allergen binding by oLCs during mucosal allergen resorption and its impact on oLC functions...
  47. ncbi Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen
    R D'Avino
    Institute of Protein Biochemistry, CNR, Naples, Italy
    Allergy 66:870-7. 2011
    ..Kiwifruit is an important cause of food allergy. A high amount of a protein with a molecular mass compatible with that of Bet v 1 was observed in the kiwifruit extract...
  48. ncbi Isoform identification and characterization of Art v 3, the lipid-transfer protein of mugwort pollen
    Gabriele Gadermaier
    Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    Mol Immunol 46:1919-24. 2009
    ..The newly identified sequences provide the basis for recombinant mugwort LTP production enabling batch-to-batch reproducibility and thus ensuring high-quality products for diagnosis and therapy...
  49. ncbi House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium
    Irene H Heijink
    Department of Allergology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 42:69-79. 2010
    ..We propose that TGF-beta secretion and dysregulated EGFR signaling may increase epithelial vulnerability to allergens and trigger the induction of EMT, a hitherto unrecognized contributor to airway remodeling in asthma.
  50. ncbi Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy
    Anaïs Pipet
    INSERM U 915, l institut du thorax, 1 rue Gaston Veil, Nantes F 44000, France
    Respir Med 103:800-12. 2009
    ..Most recently sublingual tablets were proposed in allergic rhinitis. This paper reviews the mechanisms of SIT, the evidence of efficacy of SIT from the injective to the sublingual route and reminds the current guidelines...
  51. ncbi Towards a cure for food allergy
    Justin M Skripak
    Mount Sinai School of Medicine, New York, NY, United States
    Curr Opin Immunol 20:690-6. 2008
    ..Allergen non-specific approaches include biologics to suppress free total IgE levels (e.g. anti-IgE antibody) or to induce more general immune suppression (Chinese herbal medication)...
  52. ncbi Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens
    M Lombardero
    Dept I D, ALK Abelló SA, Madrid, Spain
    Clin Exp Allergy 34:1415-21. 2004
    Artemisia vulgaris is a widespread weed in the Mediterranean area and several allergens have been detected in its pollen...
  53. ncbi Development of a peptide reactivity assay for screening contact allergens
    G Frank Gerberick
    Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45253 8707, USA
    Toxicol Sci 81:332-43. 2004
    ..The majority of chemical allergens is electrophilic and as such reacts with nucleophilic amino acids like cysteine or lysine...
  54. ncbi Quantitative measurement of IgE antibodies to purified allergens using streptavidin linked to a high-capacity solid phase
    Elizabeth A Erwin
    University of Virginia Astma and Allergic Diseases Center, Charlottesville, VA 22908-1355, USA
    J Allergy Clin Immunol 115:1029-35. 2005
    ..units per milliliter for many allergen extracts, but this is not easily achieved with purified or novel allergens. OBJECTIVE: To develop assays for IgE antibody suitable for purified or novel allergens by using a commercially ..
  55. ncbi Climate change, air quality, and human health
    Patrick L Kinney
    Department of Environmental Health Sciences, Mailman School of Public Health at Columbia University, New York, New York 10032, USA
    Am J Prev Med 35:459-67. 2008
    ..Based on the observed and anticipated impacts, adaptation strategies and research needs are discussed...
  56. ncbi Allergen databases: current status and perspectives
    Adriano Mari
    Center for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
    Curr Allergy Asthma Rep 9:376-83. 2009
    ..on allergenic molecules have been published during the past 20 years, and the number of proteins reported as allergens is close to 1500 (http://www.allergome.org)...
  57. ncbi Air pollution and allergic disease
    Haejin Kim
    Department of Internal Medicine, University of Cincinnati College of Medicine, OH 45267 0563, USA
    Curr Allergy Asthma Rep 9:128-33. 2009
    ..Health care providers and the general community should also support public policy designed to improve outdoor air quality by developing programs that provide incentives for industry to comply with controlling pollution emissions...
  58. ncbi Characterisation of major peptides in 'jack jumper' ant venom by mass spectrometry
    Noel W Davies
    Central Science Laboratory, University of Tasmania, Private Bag 74, Hobart 7001, Tasmania, Australia
    Toxicon 43:173-83. 2004
    ..Further IgE-binding studies using these peptides are warranted and a revision of the nomenclature of allergenic components of M. pilosula venom may be required to conform with established IUIS guidelines...
  59. ncbi Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age
    Martin Penagos
    Division of Allergy and Respiratory Diseases, Department of Internal, edicine, University of Genoa, Genoa, Italy
    Chest 133:599-609. 2008
    ..We evaluated the efficacy of SLIT in the treatment of allergic asthma in children by a metaanalysis of randomized, double-blind, and placebo-controlled (DBPC) clinical trials...
  60. ncbi The ACVD task force on canine atopic dermatitis (IV): environmental allergens
    P B Hill
    Department of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Edinburgh EH25 9RG, Scotland, UK
    Vet Immunol Immunopathol 81:169-86. 2001
    Numerous environmental allergens have been incriminated in the pathogenesis of canine atopic dermatitis (AD)...
  61. ncbi Allergens are distributed into few protein families and possess a restricted number of biochemical functions
    Christian Radauer
    Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 121:847-52.e7. 2008
    Existing allergen databases classify their entries by source and route of exposure, thus lacking an evolutionary, structural, and functional classification of allergens.
  62. ncbi Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults
    Meri K Tulic
    Meakins Christie Laboratories, Notre Dame Hospital and Institut ORL de Montréal, Montreal, Quebec, Canada
    Lancet 363:1689-97. 2004
    ..We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults...
  63. ncbi IgE cross-reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1
    N Acevedo
    Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    Allergy 64:1635-43. 2009
    ..The objective of this study was to investigate immunoglobulin E (IgE) cross-reactivity between Ascaris and two domestic mites in the tropics...
  64. ncbi Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Immunol 10:1211-6. 1998
    ..We have cloned A. fumigatus allergens from a cDNA library displayed on phage surface, sequenced the inserts and produced recombinant proteins in ..
  65. ncbi Roasted hazelnuts--allergenic activity evaluated by double-blind, placebo-controlled food challenge
    K Skamstrup Hansen
    Allergy Clinic, Department 7551, National University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
    Allergy 58:132-8. 2003
    ..Immunoblotting experiments with recombinant hazelnut allergens showed sensitization against Cor a 1.04 in 16/17 patients and against Cor a 2 in 7/17 patients...
  66. ncbi Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses
    A J Coyle
    Department of Biology, Inflammation Division, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Exp Med 190:895-902. 1999
    ..Taken together, our data demonstrate an important role of T1/ST2 in Th2-mediated inflammatory responses and suggest that T1/ST2 may prove to be a novel target for the selective suppression of Th2 immune responses...
  67. ncbi House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    Hamida Hammad
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Medicine, Ghent University, Ghent, Belgium
    Nat Med 15:410-6. 2009
    ..Our data identify an innate immune function of airway epithelial cells that drives allergic inflammation via activation of mucosal DCs...
  68. ncbi Multiple microbial exposures in the home may protect against asthma or allergy in childhood
    J E Sordillo
    Channing Laboratory, Boston, MA, USA
    Clin Exp Allergy 40:902-10. 2010
    ....
  69. ncbi Lipid transfer proteins from Rosaceae fruits share consensus epitopes responsible for their IgE-binding cross-reactivity
    Jean Philippe Borges
    Surfaces Cellulaires et Signalisation chez les Végétaux, UMR Université Paul Sabatier CNRS 5546, 24 Chemin de Borde Rouge, 31326 Castanet Tolosan, France
    Biochem Biophys Res Commun 365:685-90. 2008
    ..have been characterized that cover a large area (40%) of the molecular surface of lipid transfer protein allergens of Rosaceae (apple, peach, apricot, and plum)...
  70. ncbi Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung
    Christina C Lewis
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:795-804.e8. 2009
    ..Although these 2 cytokines share signaling components, the molecular mechanisms by which they mediate different phases of the allergic asthmatic response remain elusive...
  71. ncbi Allergen specific immunotherapy for atopic dermatitis
    Natalija Novak
    Department of Dermatology, University of Bonn, Bonn, Germany
    Curr Opin Allergy Clin Immunol 7:542-46. 2007
    ..To describe recent developments as well as the pros and cons of allergen specific immunotherapy as a putative therapeutic option for a subgroup of patients with atopic dermatitis...
  72. ncbi Pathogenesis of atopic dermatitis: new developments
    Thomas Bieber
    Department of Dermatology and Allergy, Rheinische Friedrich Wilhelms University Bonn, Bonn, Germany
    Curr Allergy Asthma Rep 9:291-4. 2009
    ..This review aims to summarize the most recent findings in this field...
  73. ncbi Development of a novel peptide microarray for large-scale epitope mapping of food allergens
    Jing Lin
    Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 124:315-22, 322.e1-3. 2009
    ..The peptide microarray is a novel assay that facilitates high-throughput screening of peptides with a small quantity of sample...
  74. ncbi Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2
    Hideaki Kouzaki
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 183:1427-34. 2009
    ..models suggest roles for protease(s) in Th2-type immune responses, we hypothesized that proteases from airborne allergens may induce TSLP production in a human airway epithelial cell line, BEAS-2B...
  75. ncbi Epidemiology of anaphylaxis
    Mimi L K Tang
    Department of Allergy and Immunology, Royal Children s Hospital, Melbourne, Australia
    Curr Opin Allergy Clin Immunol 9:351-6. 2009
    ..This review examines recent developments in the epidemiology of anaphylaxis, focusing on new information that may assist in identifying those at increased risk of severe reactions and adverse outcomes...
  76. ncbi Elevated peripheral allergen-specific T cell response is crucial for a positive atopy patch test reaction
    Catharina Johansson
    Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital, Stockholm SE 171, Sweden
    Int Arch Allergy Immunol 150:51-8. 2009
    ..Here we investigate the relationship between APT reactions and allergen-specific peripheral IgE and T cell reactivity in atopic eczema patients...
  77. ncbi Causes of food-induced anaphylaxis in Italian adults: a multi-centre study
    R Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
    Int Arch Allergy Immunol 150:271-7. 2009
    Data about food-induced anaphylaxis in Italy are missing. Objective: It was the aim of this study to detect the main foods/food allergens causing anaphylaxis in Italy.
  78. ncbi Latex allergy: a model for therapy
    J M Rolland
    Department of Immunology, Monash University, Melbourne, Vic, Australia
    Clin Exp Allergy 38:898-912. 2008
    ..Subjects with fruit and vegetable allergy are also at risk due to cross-reactive allergens. Following the significant advances in the identification and characterization of common aeroallergens, latex ..
  79. ncbi Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma
    Frank Kirstein
    Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Health Sciences Faculty, University of Cape Town and International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa
    J Allergy Clin Immunol 126:347-54. 2010
    ..In vitro studies have suggested that IL-4 receptor alpha (IL-4Ralpha) signaling on smooth muscle cells is critical for airway inflammation and airway hyperresponsiveness...
  80. ncbi GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe
    L M Heinzerling
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 64:1498-506. 2009
    ..Thus, it has been difficult to compare results from different centres or studies across Europe. It was, therefore, crucial to standardize and harmonize procedures in allergy diagnosis and treatment within Europe...
  81. ncbi Prolonged eosinophil production after allergen exposure in IFN-gammaR KO mice is IL-5 dependent
    L L Zhao
    Lung Pharmacology Group, Department of Internal Medicine Respiratory and Allergology, The Sahlgrenska Academy, Goteborg University, Gothenburg, Sweden
    Scand J Immunol 67:480-8. 2008
    ..In this model of a Th2-driven prolonged allergic eosinophilia, new eosinophils contribute to the extended inflammation in the airways by enhanced BM eosinophilopoiesis in an IL-5-dependent manner...
  82. ncbi Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-beta expression
    Charles Pilette
    Upper Respiratory Medicine, Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, U K
    J Immunol 178:4658-66. 2007
    ....
  83. ncbi Recombinant allergens for immunotherapy
    Rudolf Valenta
    Christian Doppler Laboratory for Allergy Research, Division of Immunopathology, Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 119:826-30. 2007
    Recombinant allergens can be produced as defined molecules in consistent quality and unlimited amounts according to the corresponding DNA template...
  84. ncbi Gal d 6 is the second allergen characterized from egg yolk
    Alvaro Amo
    Department of Allergology, Complejo Asistencial, Avda del Cid, Burgos, Spain
    J Agric Food Chem 58:7453-7. 2010
    ..Thus, a second egg yolk allergen has been described and designated Gal d 6 by the World Health Organization (WHO)/International Union of Immunological Societies (IUIS) Allergen Nomenclature Subcommittee...
  85. ncbi Contact allergy to allergens of the TRUE-test (panels 1 and 2) has decreased modestly in the general population
    J P Thyssen
    National Allergy Research Centre, Department of Dermato Allergology, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark
    Br J Dermatol 161:1124-9. 2009
    ..The prevalence of contact allergy in the general population is nearly 20%...
  86. ncbi Characterization of peach thaumatin-like proteins and their identification as major peach allergens
    A Palacin
    Unidad de Bioquimica, Departamento de Biotecnologia, E T S Ingenieros Agronomos, UPM, Madrid, Spain
    Clin Exp Allergy 40:1422-30. 2010
    ..However, the involvement of other allergenic families cannot be ruled out. Thaumatin-like proteins (TLPs) have been described as food allergen in several fruits, such as apple, cherry, kiwi and banana, and pollen...
  87. ncbi The panel of egg allergens, Gal d 1-Gal d 5: Their improved purification and characterization
    Benedikte Jacobsen
    DTU BioSys, Technical University of Denmark, Lyngby, Denmark
    Mol Nutr Food Res 52:S176-85. 2008
    ..Although the egg white allergens Gal d 1, 2, 3 and 4 (ovomucoid, ovalbumin, ovotransferrin, and lysozyme) are commercially available, these ..
  88. ncbi Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study
    Louis J Vaickus
    Boston University School of Medicine, Department of Pathology and Laboratory Medicine, Boston, MA, USA
    Respir Res 11:160. 2010
    ..In this study we endeavored to induce oral tolerance to cockroach allergen (CRA: a complex mixture of insect components) in order to ameliorate asthma-like, allergic pulmonary inflammation...
  89. ncbi Airway house dust extract exposures modify allergen-induced airway hypersensitivity responses by TLR4-dependent and independent pathways
    Diane Lam
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 181:2925-32. 2008
    ....
  90. ncbi Skin prick test reactivity to common allergens among women in Entebbe, Uganda
    Harriet Mpairwe
    MRC UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute, P O Box 49, Entebbe, Uganda
    Trans R Soc Trop Med Hyg 102:367-73. 2008
    ..14, 95% CI 0.03-0.69); women with a history of asthma were less likely to have hookworm (adjusted odds ratio 0.24, 95% CI 0.07-0.81) but this association was weaker for women with a history of eczema. [Clinical Trial No. ISRCTN32849447]...
  91. ncbi A draining lymph node assay (DLNA) for assessing the sensitizing potential of proteins
    Darrell R Boverhof
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Toxicol Lett 193:144-51. 2010
    ..These data illustrate both the opportunities and challenges associated with the examination of the draining lymph node proliferative response to assess the allergenic potential of proteins...
  92. ncbi Treatment of established asthma in a murine model using CpG oligodeoxynucleotides
    Joel N Kline
    Department of Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 283:L170-9. 2002
    ..Unlike previous studies, these data demonstrate that the combination of CpG ODN and allergen can effectively reverse established atopic eosinophilic airway disease, at least partially through redirecting a Th2 to a Th1 response...
  93. ncbi Mechanisms of allergen-specific immunotherapy: T-regulatory cells and more
    Johan Verhagen
    Swiss Institute of Allergy and Asthma Research (SIAF, Obere Strasse 22, CH-7270 Davos, Switzerland
    Immunol Allergy Clin North Am 26:207-31, vi. 2006
    ..effector T cells to a Treg-cell phenotype seems to be crucial in maintaining a healthy immune response to allergens and successful allergen-specific immunotherapy...
  94. ncbi Performance evaluation of a specific IgE assay developed for the ADVIA centaur immunoassay system
    Anita Birgit Petersen
    In Vitro Diagnostics Business Unit, ALK ABELLO, Denmark
    Clin Biochem 37:882-92. 2004
    ..To develop and evaluate a liquid phase immunoassay for accurate determination of allergen-specific IgE (sIgE) as a useful tool in the diagnosis of allergy patients...
  95. ncbi Use of acetaminophen and the risk of self-reported allergic symptoms and skin sensitization in Butajira, Ethiopia
    Gail Davey
    Department of Community Health, Addis Ababa University, Addis Ababa, Ethiopia
    J Allergy Clin Immunol 116:863-8. 2005
    ..Studies in developed countries suggest that acetaminophen use is associated with increased risk of asthma, but it is unclear whether this association is causal...
  96. ncbi Evaluation of risk factors in patients diagnosed with bronchial asthma
    M Reha Cengizlier
    Department of Allergy, Ministry of Health, Ankara Diskapi Children's Diseases Training and Research Hospital, Ankara, Turkey
    Allergol Immunopathol (Madr) 34:4-9. 2006
    ..9% of the patients were atopic on the skin prick test. RESULTS: Asthma seems to be an important health problem in our country. Recognizing the risk factors is important for the diagnosis and prevention of the disease...
  97. ncbi Allergy to kiwi in patients with baker's asthma: identification of potential cross-reactive allergens
    Arantxa Palacin
    Unidad de Bioquimica, Departamento de Biotecnologia, E T S Ingenieros Agronomos, UPM, Madrid, Spain
    Ann Allergy Asthma Immunol 101:200-5. 2008
    ..Allergy to kiwifruit has being increasingly reported in the past few years. No association between both allergic disorders has been described so far...
  98. ncbi [Allergies and hypersensibility in childhood and adult]
    Gisele Kanny
    EA 3999 maladies allergiques diagnostic et thérapeutique, Allergologie et Immunologie Clinique, Centre Hospitalier Universitaire, Hopital Central, 54035 Nancy Cedex
    Rev Prat 57:1129-37. 2007
  99. ncbi [Allergy-related hypereosinophilia]
    Gilles Garcia
    Service des Explorations Fonctionnelles Respiratoires, Hopital Antoine Beclere, Clamart
    Presse Med 35:135-43. 2006
    ..Atopy is diagnosed primarily by cutaneous skin-prick tests and the new multi-allergen blood test. A diagnosis of allergy requires the presence of symptoms and justifies workups for asthma, rhinitis, food allergies, or atopic dermatitis...
  100. ncbi Differentiation of IgE-dependent and IgE-independent reactions in children with bronchial asthma on the basis of TOP CAST Paediatric Allergen Mix test
    D Korol
    Department of Paediatric Allergology, Medical University of Białystok, Children Clinical Hospital, Ul Waszyngtona 17, 15 274 Białystok, Poland
    Adv Med Sci 51:232-6. 2006
    ..in vitro test based on evaluation of leukotrienes synthesised by basophils under the influence of specific allergens. The aim of the study was evaluation of applicability of this test as screening examination in diagnosis of ..
  101. ncbi Date palm pollen allergoid: characterization of its chemical-physical and immunological properties
    G Mistrello
    Lofarma S p A, Milan, Italy
    Int Arch Allergy Immunol 145:224-30. 2008
    ....

Research Grants80

  1. Host Defense Mechanisms in Chronic Lung Disease
    Jo Rae Wright; Fiscal Year: 2007
    ..with cells of both the adaptive and innate immune systems to coordinately maximize defense against inhaled allergens and that cause and exacerbate asthma, while minimizing an over exuberant immune response that could result in ..
  2. Mapping for Specialized Domains for FCeRI Signaling & Internalization
    Bridget S Wilson; Fiscal Year: 2010
    By crosslinking IgE bound to the high affinity IgE receptor, FceRI, allergens initiate a complex sequence of events leading to release of mast cell inflammatory mediators...
  3. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
    ..These studies have provided extensive evidence about effects of chronic exposure to indoor allergens, as well as the relevance of viruses to acute episodes in the hospital; the role of chronic sinus disease; and ..
  4. Therapeutic Strategies for Environmental Lung Diseases
    James Bonner; Fiscal Year: 2007
    ..asthma or interstitial pulmonary fibrosis that result from environmental exposures to a wide variety of inhaled allergens and toxicants...
  5. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
    ....
  6. OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSING
    Thomas Robins; Fiscal Year: 2001
    ..spirometry and methacholine challenge tests, skin prick tests (for common aeroallergens and specific seafood allergens) and skin patch testing...
  7. Health Effects of CREON2000 In Asthmatic Children
    Mark Glazman; Fiscal Year: 2003
    DESCRIPTION: (provided by applicant): Indoor allergens including molds and bacterial byproducts (e.g., endotoxin) have the potential to act as protective agents versus allergens capable of sensitizing and causing allergies and asthma...
  8. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..objective of research at the University of Virginia has been to understand the role of foreign antigens or allergens in causing and maintaining the chronic inflammation of asthma...
  9. Soy Immunotherapy for Patients with Peanut Anaphylaxis
    ARVIL BURKS; Fiscal Year: 2004
    ..idea that the storage proteins in soybeans would share enough amino acid homology with the respective peanut allergens to down regulate peanut-specific T cells, we have utilized soybean protein IT in a peanut allergic mouse model ..
  10. Rapid Test for Monitoring Dust Mite Avoidance in Homes
    Martin Chapman; Fiscal Year: 2004
    b>Allergens found in the home derived from dust mites, animal dander, cockroaches and fungi are commonly associated with the development of asthma...
  11. Socio-Cultural Influences on Allergic Sensitization
    Ginger Chew; Fiscal Year: 2006
    ..In addition, we understand that housing factors influence levels of indoor allergens, such that poor housing lends rise to cockroach and mouse allergens, and high humidity is associated with high ..
  12. Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic Asthma
    Shyam Mohapatra; Fiscal Year: 2006
    ..Deviation of immune response to allergens from a pathogenic T helper-2 type response to T helper-1 type may provide a practical approach to modifying the ..
  13. DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMA
    Thomas Platts Mills; Fiscal Year: 2009
    ..By contrast, exposure to dust mite, cockroach or pollen allergens can induce sufficient IgE ab to make an important contribution to total serum IgE...
  14. DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMA
    Thomas A Platts Mills; Fiscal Year: 2010
    ..By contrast, exposure to dust mite, cockroach or pollen allergens can induce sufficient IgE ab to make an important contribution to total serum IgE...
  15. DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMA
    Thomas Platts Mills; Fiscal Year: 1992
    The objective of these studies is to improve understanding of the role that indoor allergens play in asthma and to establish effective regimes for treating the disease by reducing exposure to allergens in homes...
  16. The Epidemiology of Home Allergens and Asthma
    Diane R Gold; Fiscal Year: 2010
    Asthma is the most common disease of childhood in the United States. The role of microbial flora and allergens in asthma development is poorly understood...
  17. Early Life Exposure to Microbial Products and Asthma
    Joel Kline; Fiscal Year: 2005
    ..According to this paradigm, microbial exposures inhibit the development of Th2-skewed responses to environmental allergens, putatively through the induction of Th1 and/or regulatory-type responses...
  18. The Epidemiology of Home Allergens and Asthma
    Diane Gold; Fiscal Year: 2009
    Asthma is the most common disease of childhood in the United States. The role of microbial flora and allergens in asthma development is poorly understood...