Genomes and Genes
viral oncogene proteins
Summary: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
Publications194 found, 100 shown here
- Generation and characterization of a preventive and therapeutic HPV DNA vaccineDaejin Kim
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Vaccine 26:351-60. 2008..Thus, the hCRTE6E7L2 DNA vaccines are capable of generating potent preventive and therapeutic effects in vaccinated mice. Our data has significant clinical implications...
- Human papillomavirus is a necessary cause of invasive cervical cancer worldwideJ M Walboomers
Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
J Pathol 189:12-9. 1999..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
- Efficient intracellular assembly of papillomaviral vectorsChristopher B Buck
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892-4263, USA
J Virol 78:751-7. 2004..The results suggest that the intracellular assembly of papillomavirus structural proteins around heterologous reporter plasmids is surprisingly promiscuous and may be driven primarily by a size discrimination mechanism...
- Papillomaviruses and cancer: from basic studies to clinical applicationHarald zur Hausen
Deutsches Krebsforschungszentrum, Heidelberg, Germany
Nat Rev Cancer 2:342-50. 2002..Epidemiological studies have underlined that HPVs are the main aetiological factor for cervical cancer. But how has this knowledge been translated into the clinic to allow the prevention, screening and treatment of cervical cancer?..
- Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteinsTae Woo Kim
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Clin Invest 112:109-17. 2003..Thus, coadministration of DNA vaccines with DNA encoding antiapoptotic proteins represents an innovative approach to enhance DNA vaccine potency...
- Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7N R Chu
StressGen Biotechnologies Corporation, Victoria, B C, Canada, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Clin Exp Immunol 121:216-25. 2000..These studies extend previous observations on the induction of cytotoxic T lymphocytes by hsp fusion proteins and are consistent with the clinical application of hspE7 as an immunotherapy for human cervical and anal dysplasia and cancer...
- Predicting indirect readout effects in protein-DNA interactionsYongli Zhang
Departments of Chemistry and Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA
Proc Natl Acad Sci U S A 101:8337-41. 2004..The sole exception was traced to differential magnesium ion binding...
- Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteinsMako Narisawa Saito
Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
Cancer Sci 98:1505-11. 2007..In the present article, the mechanisms of HPV16 E6- and E7-induced multistep carcinogenesis and recently identified functions of these onco-proteins are reviewed...
- Viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleusMartin Sapp
Department of Microbiology and Immunology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
FEBS J 276:7206-16. 2009..This minireview summarizes recent advances in our understanding of cell surface events, internalization and the subsequent intracellular trafficking of papillomaviruses...
- Neutralization of HPV16, 18, 31, and 58 pseudovirions with antisera induced by immunizing rabbits with synthetic peptides representing segments of the HPV16 minor capsid protein L2 surface regionKazunari Kondo
Center for Pathogen Genomics, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Virology 358:266-72. 2007..The cross-neutralization appears to be correlated with conserved aa sequences among HPV types. The data in this study provide a basis for designing vaccine antigens effective against a broader spectrum of the high-risk HPVs...
- TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16Uzma A Hasan
International Agency for Research on Cancer World Health Organization, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
J Immunol 178:3186-97. 2007....
- Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interferenceMing Jiang
YCR P53 Research Group, Department of Biology, University of York, York YO10 5DD, UK
Oncogene 21:6041-8. 2002....
- Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytesM Nees
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA
J Virol 75:4283-96. 2001..Thus, high-level expression of the HPV-16 E6 protein in differentiating keratinocytes directly alters expression of genes that influence host resistance to infection and immune function...
- Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoproteinT Veldman
Departments of Pathology and Oncology, Georgetown University Medical School, Washington, D.C. 20007, USA
J Virol 75:4467-72. 2001....
- Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cellsA Hengstermann
Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, , Germany
Proc Natl Acad Sci U S A 98:1218-23. 2001....
- Human papillomavirus type 16 L1E7 chimeric capsomeres have prophylactic and therapeutic efficacy against papillomavirus in miceTao Bian
Biotech Center for Viral Disease Emergency, Yingxin Street 100, Xuanwu District, Beijing 100052, People s Republic of China
Mol Cancer Ther 7:1329-35. 2008..Chimeric capsomeres are capable of preventing and eliminating HPV16 infection. Therefore, our study has provided an economical vaccine candidate...
- Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancersBassam Abdulkarim
, Institut Gustave-Roussy, 94805 Villejuif, France
Oncogene 21:2334-46. 2002..This study provides the basis for a new anticancer strategy to enhance the antitumor effect of ionizing radiation in HPV-related cancers, without increase deleterious effects...
- Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcriptsN Hafner
Frauenklinik der Friedrich Schiller Universität, Jena, Germany
Oncogene 27:1610-7. 2008..Instead, constitutive expression of oncogene transcripts rather than the level of expression appears to be decisive for transformation and the maintenance of the malignant phenotype...
- HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cellsF A Suprynowicz
Department of Pathology, Georgetown University Medical School, Washington, DC 20057, USA
Oncogene 27:1071-8. 2008..Finally, the upregulation of caveolin-1 and ganglioside GM1 at the plasma membrane of E5-expressing cervical cells provides potential new therapeutic targets and diagnostic markers for high-risk HPV infections...
- Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130K Smith-McCune
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco CA 94115, USA
Proc Natl Acad Sci U S A 96:6999-7004. 1999..Induction of E7 function was not correlated with binding to p130 or pRb but rather with intranuclear localization and modest induction of binding to p107...
- Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesisH zur Hausen
Deutsches Krebsforschungszentrum, Heidelberg, Germany
J Natl Cancer Inst 92:690-8. 2000..Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis...
- Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccinesChristina Schellenbacher
Laboratory of Viral Oncology, Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University Vienna, Austria
J Virol 83:10085-95. 2009....
- Mechanisms of human papillomavirus-induced oncogenesisKarl Munger
Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, NRB 0958C, Boston, MA 02115 5727, USA
J Virol 78:11451-60. 2004
- Chimeric human papillomavirus type 16 (HPV-16) L1 particles presenting the common neutralizing epitope for the L2 minor capsid protein of HPV-6 and HPV-16Arvind Varsani
Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa and Department of Pathology, The Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA
J Virol 77:8386-93. 2003..Moreover, it contributes to knowledge of the structure of HPV-16 L1 VLPs and their derivatives...
- Biological activities and molecular targets of the human papillomavirus E7 oncoproteinK Munger
Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, MA 02115, USA
Oncogene 20:7888-98. 2001..The transforming activities of E7 largely reflect this important function...
- Induction of human papilloma virus E6/E7-specific cytotoxic T-lymphocyte activity in immune-tolerant, E6/E7-transgenic miceA Riezebos-Brilman
Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen (UMCG, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands
Gene Ther 12:1410-4. 2005..We demonstrate that, depending on the route of immunization, SFV-expressing HPV16 E6 and E7 indeed has the capacity to induce HPV16 E7-specific cytotoxic T cells in HPV-transgenic mice...
- HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytesBenyue Zhang
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
Oncogene 24:2585-8. 2005..This novel result suggests that HPV16 E5 may, at least in part, upregulate EGFR-mediated signal transduction by inhibiting the interaction of c-Cbl with the EGFR, thereby decreasing c-Cbl-mediated degradation of the EGFR...
- Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogeneSybil M Genther Williams
McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
Cancer Res 65:6534-42. 2005..Through the analysis of these mice, we show a requirement of the epidermal growth factor receptor for the hyperplastic properties of E5...
- Overlapping and independent structural roles for human papillomavirus type 16 L2 conserved cysteinesMichael J Conway
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Virology 393:295-303. 2009..These results suggest that Cys28 is necessary for late-stage stabilization of capsids, while Cys22 is necessary for proper display of L2 neutralizing epitopes...
- Comparative analysis of the intracellular location of the high- and low-risk human papillomavirus oncoproteinsErnesto Guccione
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy
Virology 293:20-5. 2002..These results demonstrate fundamental differences in the localization of these viral oncoproteins within the cell and offer alternative explanations for their respective differences in pathology...
- Biology of human papillomavirusesH R McMurray
Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
Int J Exp Pathol 82:15-33. 2001..While the mechanisms of action of the viral proteins are not completely understood, researchers are making progress and this article strives to bring together the conclusions from some of this work...
- Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinomaFrancoise Thierry
Institute of Medical Biology, Singapore, Singapore
Virology 384:375-9. 2009..We will describe the role played by the viral E2 proteins in the transcriptional repression of the high risk HPV oncogenes and its implication in cervical cancer...
- Human papillomavirus: E6 and E7 oncogenesGaëlle Boulet
AMBIOR, Laboratory for Cell Biology and Histology, University of Antwerp, Groenenborgerlaan 171, BE 2020 Antwerp, Belgium
Int J Biochem Cell Biol 39:2006-11. 2007..Although prophylactic vaccines are available, further understanding of the viral life cycle and the mechanisms underlying HPV-induced oncogenesis is necessary to face the many challenges in the field of HPV and cancer...
- Arrangement of L2 within the papillomavirus capsidChristopher B Buck
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 5624, USA
J Virol 82:5190-7. 2008..This structural information should facilitate investigation of L2 function during the assembly and entry phases of the papillomavirus life cycle...
- Stable replication of papillomavirus genomes in Saccharomyces cerevisiaePeter C Angeletti
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
J Virol 76:3350-8. 2002....
- Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2Diana V Pastrana
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
Virology 337:365-72. 2005..BPV1 L2 was exceptionally effective at inducing cross-neutralizing antibodies to these shared epitopes...
- Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sitesS T Oh
Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
J Virol 75:5559-66. 2001..This indicates that it is the combinatorial binding of factors to Myc and Sp1 cis elements that is responsible for hTERT induction by E6...
- Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancerKatsuyuki Hamada
Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Shitsukawa, Toon, Ehime 791 0295, Japan
Gynecol Oncol 103:820-30. 2006..We are exploring the potential use of antisense HPV RNA transcripts for gene therapy for HPV-positive cervical cancers...
- The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoproteinXuefeng Liu
Department of Pathology and Oncology, Georgetown University Medical School, 3900 Reservoir Rd NW, Washington, DC 20057, USA
J Biol Chem 280:10807-16. 2005....
- Codon optimized expression of HPV 16 E6 renders target cells susceptible to E6-specific CTL recognitionRegina Samorski
Deutsches Krebsforschungszentrum, Heidelberg, Forschungsschwerpunkt Infektionen und Krebs, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
Immunol Lett 107:41-9. 2006..Both findings are of potential relevance for the design of tumor vaccines...
- Construction and characterization of recombinant fowlpox viruses expressing human papilloma virus E6 and E7 oncoproteinsEleana Pozzi
Department of Medical Pharmacology, University of Milan, Milan, Italy
J Virol Methods 158:184-9. 2009..The results indicate that FPV recombinants can express correctly the E6 and E7 oncoproteins, and they should represent appropriate vectors for the expression of these oncoproteins in human cells...
- The E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16- or type 18-positive cervical cancer cell lines via translation reinitiationShuang Tang
HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI NIH, 10 Center Dr, Rm 10 S255, MSC 1868, Bethesda, Maryland 20892 1868, USA
J Virol 80:4249-63. 2006..The data thus provide direct evidence that the E6*I mRNAs of high-risk HPVs are responsible for E7 production...
- A Phase 1 study of a recombinant viruslike particle vaccine against human papillomavirus type 11 in healthy adult volunteersT G Evans
Infectious Diseases Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Infect Dis 183:1485-93. 2001..This candidate HPV VLP vaccine induced robust B and T cell responses, and T cell helper epitopes appear to be conserved across HPV types...
- Production of human papillomavirus type 16 virus-like particles in transgenic plantsSophia Biemelt
, 06466 Gatersleben, Germany
J Virol 77:9211-20. 2003..Our data, however, indicate that an anti-L1 response was primed in about half of the 24 animals...
- Oligomerization of the E5 protein of human papillomavirus type 16 occurs through multiple hydrophobic regionsChristine E Gieswein
Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
Virology 313:415-26. 2003..The majority of E5 expressed in HEK 293-T7 cells was perinuclear but did not appear to localize to the cis/medial-Golgi, in contrast to previous reports for both HPV16 E5 and BPV1 E5...
- Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cellsQ Gao
Department of Radiation Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
J Virol 75:4459-66. 2001..The tight correlation between E6TP1 degradation and MEC immortalization strongly supports a critical role of functional inactivation of E6TP1 in E6-induced cellular immortalization...
- The E7 oncoprotein of high-risk human papillomavirus type 16 enters the nucleus via a nonclassical Ran-dependent pathwayMichael Angeline
Biology Department, Boston College, Chestnut Hill, MA 02467, USA
Virology 317:13-23. 2003..Together the data suggest that HPV16 E7 translocates through the nuclear pores via a nonclassical Ran-dependent pathway, independent of the main cytosolic Kap beta import receptors...
- Retinoic acid-mediated G1-S-phase arrest of normal human mammary epithelial cells is independent of the level of p53 protein expressionV L Seewaldt
Department of Medicine, University of Washington, Seattle, USA
Cell Growth Differ 10:49-59. 1999..Our results emphasize the chemotherapeutic potential of ATRA and antiestrogens, particularly for suppressing the growth of tumors lacking functional p53...
- The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53M Scheffner
Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892
Cell 75:495-505. 1993..The ubiquitination of p53 requires the E1 enzyme and a novel E2 in mammalian cells, while E3 activity is conferred by the E6-E6-AP complex. Furthermore, E6-AP appears to have ubiquitin-protein ligase activity in the absence of E6...
- Mutational analysis of human papillomavirus type 16 major capsid protein L1: the cysteines affecting the intermolecular bonding and structure of L1-capsidsYoshiyuki Ishii
Division of Molecular Genetics, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan
Virology 308:128-36. 2003....
- Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunityBalasubramanyam Karanam
Department of Pathology, The Johns Hopkins University, Baltimore, MD 21231, USA
Vaccine 27:1040-9. 2009....
- Mechanisms of cell transformation by papillomavirus E5 proteinsD DiMaio
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Oncogene 20:7866-73. 2001..Further analysis of these unique mechanisms of viral transformation will yield new insight into the regulation of growth factor receptor activity and cellular signal transduction pathways...
- Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding proteinJ J Chen
Department of Dermatology, New England Medical Center, Boston, MA, USA
Science 269:529-31. 1995..The transforming activity of BPV-1 E6 mutants correlated with their E6BP-binding ability. E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum...
- Ubiquitin-fused and/or multiple early genes from cottontail rabbit papillomavirus as DNA vaccinesSancy A Leachman
Department of Dermatology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
J Virol 76:7616-24. 2002..This last vaccine prevented papilloma formation at all challenge sites in all rabbits, demonstrating complete protection...
- A novel human papillomavirus type 6 neutralizing domain comprising two discrete regions of the major capsid protein L1W L McClements
Department of Virus and Cell Biology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Virology 289:262-8. 2001..This suggests that clusters of diverged residues, surrounded by conserved L1 sequences, are presented on the surface of assembled particles and are responsible for eliciting critical humoral immune responses to the virus...
- Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activityWen Jun Liu
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
Virology 301:43-52. 2002..However, this may be insufficient for priming E7 responses in animals with split tolerance to E7 as a consequence of expression of E7 in somatic cells...
- Synthetic peptides induce a cytotoxic response against human papillomavirus type-18M R Castellanos
Department of Medicine, Nalitt Institute for Cancer and Blood Related Diseases, Staten Island, New York, 10305, USA
Gynecol Oncol 82:77-83. 2001..These two epitopes are candidates for a peptide-based vaccine against HPV-18(+) tumors. The model described has broad applications and can be used in the development of immunotherapy for other types of cancers...
- Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeresE C Goodwin
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Cell Growth Differ 12:525-34. 2001..Cells carrying the hTERT gene and control cells displayed identical responses to E2 expression. Therefore, HeLa cell senescence induced by HPV repression is not triggered by short telomeres or low levels of telomerase activity...
- The human papillomavirus type 16 E5 protein impairs TRAIL- and FasL-mediated apoptosis in HaCaT cells by different mechanismsKirsten Kabsch
Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
J Virol 76:12162-72. 2002..We propose that inhibition of ligand-mediated apoptosis in human keratinocytes is a primary function of the HPV-16 E5 protein needed to prevent apoptosis at early stages of viral infection...
- Deletion of a major neutralizing epitope of human papillomavirus type 16 virus-like particlesJ Ryding
Department of Medical Microbiology, Malmo University Hospital, Lund University, UMAS, S 205 02 Malmo, Sweden
J Gen Virol 88:792-802. 2007....
- Viral DNA load, physical status and E2/E6 ratio as markers to grade HPV16 positive women for high-grade cervical lesionsMonica Cricca
Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, and Department of Obstetrics and Gynecology, S Orsola Malpighi Hospital, Italy
Gynecol Oncol 106:549-57. 2007..This study has evaluated the significance of viral markers, such as viral load, physical status and E2/E6 ratio, to stratify HPV16 infected women at a single point in time for grade of cervical lesions...
- The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instabilityStefan Duensing
Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 62:7075-82. 2002..Our results therefore suggest that HPV oncoproteins are a source for both numerical and structural chromosome instability during HPV-associated carcinogenesis...
- Association of human papillomavirus types 16 and 18 E6 proteins with p53B A Werness
Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892
Science 248:76-9. 1990....
- HPV16 semiquantitative viral load and serologic biomarkers in oral and oropharyngeal squamous cell carcinomasAimee R Kreimer
International Agency for Research on Cancer, Lyon, France
Int J Cancer 115:329-32. 2005....
- Human papillomavirus type 16 E2 and E6/E7 variantsDavid C Swan
U S Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Atlanta, GA 30333, USA
Gynecol Oncol 96:695-700. 2005....
- HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter functionXuefeng Liu
Department of Pathology and Oncology, Georgetown University Medical School, Washington, DC 20057, USA
Virology 375:611-23. 2008..Thus, HPV E7 plays a role in the maintenance of telomerase activity in stable cell lines and augments acute, E6-induced hTERT promoter activity...
- Centrosome-mediated chromosomal instability and steroid hormones as co factors in human papillomavirus-associated cervical carcinogenesis: small viruses help to answer big questionsAnette Duensing
Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Adv Exp Med Biol 617:109-17. 2008
- Physical status of HPV-16 in esophageal squamous cell carcinomaHua Xin Si
Department of Anatomy, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, PR China
J Clin Virol 32:19-23. 2005..CONCLUSION: Our finding of frequent integration of viral DNA in the host genome suggests that integration HPV-16 is common in ESCC from Chinese patients and implies that HPV infection may play a role in the pathogenesis of ESCC...
- Superior therapeutic efficacy of alphavirus-mediated immunization against human papilloma virus type 16 antigens in a murine tumour model: effects of the route of immunizationToos Daemen
Department of Medical Microbiology, Molecular Virology Section, University of Groningen, Groningen, The Netherlands
Antivir Ther 9:733-42. 2004..Thus SFV-enhE6,7 meets with the criteria that a vaccine against cervical cancer should be safe and induce a very strong, long-lasting CTL response, strong enough to eradicate existing tumours...
- Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinomaAdriana Baez
Department of Otolaryngology Head and Neck Surgery, University of Puerto Rico School of Medicine, San Juan, Puerto Rico
Clin Cancer Res 11:3191-7. 2005..This difference was statistically significant (P = 0.01) suggesting that loss of Smad4 expression may be involved in HPV16-induced carcinogenesis of HNSCC...
- Prevalence of mucosal and cutaneous human papillomaviruses in different histologic subtypes of vulvar carcinomaMaurits N C de Koning
DDL Diagnostic Laboratory, Voorburg, The Netherlands
Mod Pathol 21:334-44. 2008..The HPV 16 intratypic variation showed correlation with patients' ethnic background. P16INK4a immunostaining seems to be a sensitive and specific marker of vulvar carcinomas positive for oncogenic mucosal HPVs...
- Human papillomaviruses target the double-stranded RNA protein kinase pathwayChristy M Hebner
Department of Microbiology-Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Gen Virol 87:3183-93. 2006..This effect was mediated by the HPV E6 oncoprotein and leads to the co-localization of PKR with P-bodies. These studies demonstrate that high-risk HPVs target the PKR pathway by multiple mechanisms...
- Regulation of telomerase by human papillomavirusesD A Galloway
Program in Cancer Biology, Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA
Cold Spring Harb Symp Quant Biol 70:209-15. 2005..The NFX1-123 isoform has the opposite activity, increasing hTERT transcription or translation. This is the first example of viral oncoproteins disrupting regulation of telomerase, a critical event in tumorigenesis...
- Expression of E6/E7 mRNA from 'high risk' human papillomavirus in relation to CIN grade, viral load and p16INK4aSonia Andersson
Department for Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska University Hospital, Huddinge, Karolinska Institute, S 141 86 Stockholm, Sweden
Int J Oncol 29:705-11. 2006..Thus, E6/E7 oncogene expression analysis yielded information, which is consistent with and will complement the results from a real-time PCR method in a clinical prognostic procedure...
- Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activationJiabin An
Department of Medicine, VA Greater Los Angeles Healthcare System West Los Angeles, Los Angeles, CA 90095, USA
Cancer Cell 14:394-407. 2008..Given the established role of NF-kappaB in human carcinogenesis, these findings provide a potential molecular/viral link between hypoxia and the adverse clinical outcomes observed in HPV-associated malignancies...
- Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell linesUlrika Rolen
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Mol Carcinog 45:260-9. 2006..UCH-L1, UCH-L3, USP7, and USP9X activity was upregulated following HPV E6/E7 immortalization of keratinocytes, suggesting a role of these enzymes in growth transformation...
- Integrated human papillomavirus types 52 and 58 are infrequently found in cervical cancer, and high viral loads predict risk of cervical cancerChih-Ming Ho
Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan, ROC
Gynecol Oncol 102:54-60. 2006..Our results indicate that both viral DNA physical status and viral loads of HPV are important factors in the carcinogenesis of different HPV types...
- Transformation assays for HPV oncoproteinsPaola Massimi
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Methods Mol Med 119:381-95. 2005..In this chapter we describe how the transforming activities of the HPV oncoproteins can be assessed...
- Distinct regulation and impact of type 1 T-cell immunity against HPV16 L1, E2 and E6 antigens during HPV16-induced cervical infection and neoplasiaMariette I E van Poelgeest
Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands
Int J Cancer 118:675-83. 2006..This argues that T-cell responses against early and late HPV16 antigens essentially differ in the manner in which they are induced and regulated, as well as in their impact on the subsequent stages of HPV16-induced cervical disease...
- Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosisChandrasekhar S Divya
Department of Molecular Medicine, Regional Cancer Centre, Thiruvananthapuram, Kerala, India
Mol Carcinog 45:320-32. 2006..These results provide attractive data for the possible use of curcumin in the management of HPV associated tumors...
- Vaccine regimen for prevention of sexually transmitted infections with human papillomavirus type 16D W Kowalczyk
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Vaccine 19:3583-90. 2001..m.) for priming, followed by an intranasal (i.n.) booster immunization with the viral recombinant, induced antibodies to L1 in sera and in vaginal secretions...
- Human papillomavirus DNA is present in a subset of unselected breast cancersY Liu
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Hum Virol 4:329-34. 2001..CONCLUSIONS: These data suggest that HPV may be associated with a significant subset of breast cancers, and further suggest that additional studies are warranted...
- Time course of humoral and cell-mediated immune responses to human papillomavirus type 16 in infected womenMayumi Nakagawa
Departments of Laboratory Medicine, Schools of Medicine and Dentistry, University of California at San Francisco, San Francisco, California 94143 0134, USA
Clin Diagn Lab Immunol 9:877-82. 2002..Overall, seven of eight subjects (88%) had detectable HPV-16 E6 and/or E7 CTL responses and seven of eight women (88%) had detectable HPV-16 VLP antibody responses...
- Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomesDaniel L Sprague
Department of Microbiology, University of Iowa, Iowa City 52242, USA
Virology 301:247-54. 2002....
- Human papillomavirus type 16 and squamous cell carcinoma of the head and neckElin Ringstrom
Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Clin Cancer Res 8:3187-92. 2002..The majority of tumors were located in the oral cavity, followed by the oropharynx. A PCR-based technique with restriction fragment length polymorphism analysis was used to detect and type HPV...
- Detection of human papillomavirus DNA in malignant lesions from Chinese women with carcinomas of the upper genital tractS M Ip
Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, China
Gynecol Oncol 87:104-11. 2002..As compared to the high positive rate of HPV infections in cervical cancer, it appears that HPV infection plays a relatively minor role in the pathogenesis of endometrial and ovarian carcinomas...
- Safety and immunogenicity of TA-HPV, a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancerAndreas M Kaufmann
Frauenklinik, Friedrich Schiller University of Jena, 07743 Jena, Germany
Clin Cancer Res 8:3676-85. 2002....
- Both E7 and CpG-oligodeoxynucleotide are required for protective immunity against challenge with human papillomavirus 16 (E6/E7) immortalized tumor cells: involvement of CD4+ and CD8+ T cells in protectionTae-Yoon Kim
Department of Dermatology, The Catholic University of Korea, Seoul 137-040, Korea
Cancer Res 62:7234-40. 2002..Taken together, these data suggest that E7+ODN codelivery could be an effective approach to induce E7-specific protective immune responses as a possible immunotherapeutic strategy for cervical cancer...
- Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 micePeter Öhlschläger
Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
J Virol 77:4635-45. 2003....
- Multiple variants of HPV16 E6 gene in cervical invasive squamous cell carcinomaTianyun Pang
Department of Genetics and Pathology, Uppsala University, Sweden
Anticancer Res 22:1011-6. 2002..This finding might have implications for the future study of natural HPV evolution, the design of viral vaccine and the carcinogenesis of cervical cancer...
- Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavityPatrick K Ha
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Clin Cancer Res 8:1203-9. 2002..Furthermore, quantitative PCR is a useful technique that reliably excludes contaminated samples and those with minimal HPV DNA content that is unlikely to be significant in carcinogenesis...
- Quantitation of human papillomavirus 16 E6 and E7 DNA and RNA in residual material from ThinPrep Papanicolaou tests using real-time polymerase chain reaction analysisFeng Wang-Johanning
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
Cancer 94:2199-210. 2002..The goal of this study was to determine the potential clinical uses of real-time polymerase chain reaction (PCR) and reverse transcription-PCR (RT-PCR) methods for evaluating HPV-16 E6 and E7 oncogene expression...
- Immunization strategy against cervical cancer involving an alphavirus vector expressing high levels of a stable fusion protein of human papillomavirus 16 E6 and E7T Daemen
University of Groningen, Department of Medical Microbiology, Molecular Virology Section, Groningen, The Netherlands
Gene Ther 9:85-94. 2002..Tumor challenge experiments in mice demonstrated that immunization with SFV-enhE6,7 resulted in prevention of tumor outgrowth and subsequent protection against tumor re-challenge...
- Low level expression of human papillomavirus type 16 (HPV16) E6 in squamous epithelium does not elicit E6 specific B- or T-helper immunological responses, or influence the outcome of immunisation with E6 proteinR Azoury-Ziadeh
Centre for Immunology and Cancer Research, University of Queensland, Brisbane, Australia
Virus Res 73:189-99. 2001..There are implications for E6-mediated tumorigenesis in humans, and for the development of putative E6 therapeutic vaccines...
- Human papillomaviruses and their role in cervical cancerG Dell
Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom
Cell Mol Life Sci 58:1923-42. 2001..Several of these new avenues of research have the potential to lead to new approaches to the treatment and prevention of cervical cancer...
- Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomasV M van Houten
Department of Otolaryngology/Head and Neck Surgery, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
Int J Cancer 93:232-5. 2001..Analysis of E6 mRNA expression by RT-PCR or alternatively, semiquantitative analyses of the viral load, seem more reliable assays to assess HPV involvement in HNSCC than the very sensitive DNA PCR analyses used routinely...
- Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of ChinaT Li
Laboratory of Genetics, Beijing Institute for Cancer Research, School of Oncology, Peking University, No. 1 Da Hong Luo Chang St, Beijing 100034, China
Carcinogenesis 22:929-34. 2001..These results suggest that HVP-16 plays a causative role in the high incidence of esophageal cancer in the Anyang region of CHINA:..
- Sequence variation and physical state of human papillomavirus type 16 cervical cancer isolates from Australia and New CaledoniaKylie J Watts
Department of Infectious Diseases, The University of Sydney, New South Wales, Australia
Int J Cancer 97:868-74. 2002..No particular patterns of variation in the URR, E6 or E2/E4 genes predicted physical state. This investigation represents one of the most comprehensive studies of its kind and fills an important gap in global sequence data...
- Human papillomavirus 16 and 18 expression in conjunctival intraepithelial neoplasiaIngrid U Scott
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101, USA
Ophthalmology 109:542-7. 2002....
- A generic capture ELISA for recombinant proteins fused to glutathione S-transferase: validation for HPV serologyP Sehr
Applied Tumor Virology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, D-69120, Heidelberg, Germany
J Immunol Methods 253:153-62. 2001..The GST capture ELISA could be adapted to provide standardized antibody assays for many protein antigens...
- Molecular interactions of 'high risk' human papillomaviruses E6 and E7 oncoproteins: implications for tumour progressionOishee Chakrabarti
National Centre for Biological Sciences, Tata Institute of Fundamental Research, UAS GKVK Campus, Bangalore 560 065, India
J Biosci 28:337-48. 2003..This review focuses on the regulation of host proteins by the viral oncoproteins and consequence of such interactions on cell survival, proliferation, differentiation and apoptosis...
Research Grants136 found, 100 shown here
- Predoctoral Training Program in VirologyPeter Tattersall; Fiscal Year: 2007..abstract_text> ..
- Genomic instability induced by the HPV-16 E7 oncoproteinStefan Duensing; Fiscal Year: 2009....
- A Phase I/II Trial of a Therapeutic HPV VaccineCornelia Trimble; Fiscal Year: 2004....
- Dendritic Cell Immunotherapy for Cervical CancerAlessandro Santin; Fiscal Year: 2004..This study will determine whether E7 antigen-loaded autologous DC vaccination offers the potential of therapeutic benefit for patients with HPV16 or HPV18-associated cervical cancer. ..
- CYTOTOXIC T LYMPHOCYTE RESPONSE TO HPV 16Mayumi Nakagawa; Fiscal Year: 2002....
- THERAPEUTIC VACCINES FOR HPV DISEASESCornelia Trimble; Fiscal Year: 2005..These facilities will be used to develop Dr. Trimble's ability to design and execute clinical trials evaluating preneoplastic HPV-associated lesions of the female lower genital tract. ..
- Mechanisms of mucosal immune evasion in high grade cervical dysplasiaCornelia L Trimble; Fiscal Year: 2010....
- Transcripitonal and Genetic Profiles in HNSCCsElaine Smith; Fiscal Year: 2007..abstract_text> ..
- Understanding and Enhancing T-Cell Responses to high Risk Human PapillomavirusesMayumi Nakagawa; Fiscal Year: 2010..In addition, this project has the potential for developing a novel adjuvant capable of enhancing peptide vaccine immunogenicity, which can be applied to other cancers as well as other infectious agents. ..
- International Collaborative HNC ResearchElaine Smith; Fiscal Year: 2007..This aim is to determine whether there is an easily administered, sensitive biomarker that can predict HPV-HR status in HNC tumors prior to therapy.. ..
- GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCERElaine Smith; Fiscal Year: 2003..abstract_text> ..
- Therapeutic DNA-MVA prime boost vaccination for HPV diseaseCornelia Trimble; Fiscal Year: 2007..We have a demonstrated record in clinical trial design and execution in this patient population, which is disproportionately comprised of minority women who do not access the medical care system effectively. ..
- ANALYSIS OF THE PDGF RECEPTOR JUXTAMEMBRANE DOMAINDaniel DiMaio; Fiscal Year: 2004..These experiments should provide new insights into the function and regulation of receptor tyrosine kinases and into human tumorigenesis, and they should elucidate the binding properties of a new family of WW domains. ..
- CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUSDaniel DiMaio; Fiscal Year: 2009..abstract_text> ..
- Role of HPV16 E7/E2F6 interaction in viral oncogenesisMargaret McLaughlin Drubin; Fiscal Year: 2006..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. ..
- A tri-antigen nasal anthrax vaccine against toxins and vegetative bacilli Zhengrong Cui; Fiscal Year: 2007..The same vaccine or its modified version can also be used in agricultural industries to vaccinate cattle. ..
- Activation of NF-kB by Human PapillomavirusesCRAIG WOODWORTH; Fiscal Year: 2006..Therefore, our results will provide basic information on how HPV might alter host response to infection. ..
- VSV-based Therapeutic Papilloma VaccineJanet Brandsma; Fiscal Year: 2007..The data provided by this investigation are likely to aid in the development a highly effective HPV vaccine to protect women against cervical cancer. ..
- PAPILLOMAVIRUS HOST INTERACTIONNeil Christensen; Fiscal Year: 2007..abstract_text> ..
- CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUSDaniel DiMaio; Fiscal Year: 2010..In addition, on the basis of these studies, we will continue to develop a novel protein engineering method to control biological processes, including infection by human immunodeficiency virus, an important co-factor in many cancers. ..
- PAPILLOMAVIRUS HOST INTERACTIONNeil Christensen; Fiscal Year: 2002..Defining the major protective viral epitopes on PV virions and on the early viral proteins in papillomavirus-infected cells will be key to planning effective immunotherapeutic management of this infectious disease. ..
- ANALYSIS OF CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUSDaniel DiMaio; Fiscal Year: 1991..Because of the association of papillomavirus with human carcinomas, our findings may be relevant to understanding the genesis of human cancers...
- Development of furanones for treatment of anthraxMartin Blaser; Fiscal Year: 2005..In initial studies, spores will be given subcutaneosly. Efficacy parameters will be defined as above. Successful trials can lead to phase I studies in humans, and treatment studies in non-human primates. ..
- Mathematical models of H. pylori gastric colonizationMartin Blaser; Fiscal Year: 2007..The experimental results will enable development of deterministic models relating genotypic and phenotypic variation with selection. ..
- Cell surface events of human papillomavirus type 16 and 18 infectionMartin Sapp; Fiscal Year: 2010..This should allow identification of cellular targets for drug therapies to prevent HPV induced cancers. ..
- Mathematical models of H. pylori gastric colonizationMartin J Blaser; Fiscal Year: 2010..Including mathematical analyses in these studies also permits a generalization of the principles and their applications to other microbes involved in human health and disease. ..
- Disappearing gastrointestinal microbiota in epidemic obesity.Martin J Blaser; Fiscal Year: 2010..We will focus on both maternal and antibiotic effects on the composition of the gastric and colonic bacterial populations, and their metabolic effects. ..
- Mechanisms of the Adenovirus E4-ORF1 OncoproteinRonald T Javier; Fiscal Year: 2011....
- H PYLORI RECOMBINATION AND GASTRIC COLONIZATIONMartin Blaser; Fiscal Year: 2001..pylori infections. ..
- CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCEMartin Blaser; Fiscal Year: 2004..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
- li Suppression-enhanced HIV DNA VaccineMinzhen Xu; Fiscal Year: 2003..In a Phase II program Ii-RGC/gp120 DNA vaccines will be tested in non-human primates for the induction of a protective immune response against pathogenic HIV infection. ..
- Mechanisms of the Adenovirus E4-ORF1 OncoproteinRonald T Javier; Fiscal Year: 2010....
- Mathematical models of H. pylori gastric colonizationMartin Blaser; Fiscal Year: 2009..Including mathematical analyses in these studies also permits a generalization of the principles and their applications to other microbes involved in human health and disease. ..
- Diindolylmethane enhances the efficacy of preventive vaccines in an HPV transgeniDANIEL WAYNE SEPKOVIC; Fiscal Year: 2010..These women are at increased risk for cervical cancer. Our goal is to adapt preventive and therapeutic vaccines so that they can be used in this at risk population. ..
- HIV li-Key/Peptide VaccineMinzhen Xu; Fiscal Year: 2002..This entirely synthetic vaccine can be manufactured in a large scale and be given to those at high risk of HIV infection. ..
- MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATIONMartin Blaser; Fiscal Year: 2003..3) To examine the effect of recombination between two different H.pylori strains during experimental infections, and to develop representative mathematical models for this more complex phenomenon. ..
- CONTROL OF PAPILLOMAVIRUS EXPRESSION AND TRANSFORMATIONElliot Androphy; Fiscal Year: 2009..Understanding how E2 operates will provide insights into the biology of these pathways and infer how aberrations may occur that lead to the development of cancer. ..
- Small Molecule Inhibitors of Oncogenic Human PapillomavirusElliot Androphy; Fiscal Year: 2009..E6 is necessary for viral replication and for oncogenic progression. These compounds can be advanced to treat cervical, anogenital and head and neck cancers and their precursor lesions. ..
- ENHANCING HPV-16 E6-SPECIFIC ANTITUMOR IMMUNITYT C Wu; Fiscal Year: 2009..abstract_text> ..