viral oncogene proteins

Summary

Summary: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.

Top Publications

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
  2. ncbi The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    M Scheffner
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892
    Cell 75:495-505. 1993
  3. ncbi Papillomaviruses and cancer: from basic studies to clinical application
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nat Rev Cancer 2:342-50. 2002
  4. ncbi Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis
    H zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Natl Cancer Inst 92:690-8. 2000
  5. pmc Efficient intracellular assembly of papillomaviral vectors
    Christopher B Buck
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4263, USA
    J Virol 78:751-7. 2004
  6. ncbi Biological activities and molecular targets of the human papillomavirus E7 oncoprotein
    K Munger
    Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 20:7888-98. 2001
  7. ncbi Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference
    Ming Jiang
    YCR P53 Research Group, Department of Biology, University of York, York YO10 5DD, UK
    Oncogene 21:6041-8. 2002
  8. pmc Pathogenesis of human papillomaviruses in differentiating epithelia
    Michelle S Longworth
    Department of Microbiology Immunology, The Fineberg Medical School, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    Microbiol Mol Biol Rev 68:362-72. 2004
  9. ncbi The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    N Dyson
    Cold Spring Harbor Laboratory, NY 11724
    Science 243:934-7. 1989
  10. ncbi siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells
    Karin Butz
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, Heidelberg D 69120, Germany
    Oncogene 22:5938-45. 2003

Research Grants

Detail Information

Publications234 found, 100 shown here

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
    ..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
  2. ncbi The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    M Scheffner
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892
    Cell 75:495-505. 1993
    ..The ubiquitination of p53 requires the E1 enzyme and a novel E2 in mammalian cells, while E3 activity is conferred by the E6-E6-AP complex. Furthermore, E6-AP appears to have ubiquitin-protein ligase activity in the absence of E6...
  3. ncbi Papillomaviruses and cancer: from basic studies to clinical application
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nat Rev Cancer 2:342-50. 2002
    ..Epidemiological studies have underlined that HPVs are the main aetiological factor for cervical cancer. But how has this knowledge been translated into the clinic to allow the prevention, screening and treatment of cervical cancer?..
  4. ncbi Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis
    H zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Natl Cancer Inst 92:690-8. 2000
    ..Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis...
  5. pmc Efficient intracellular assembly of papillomaviral vectors
    Christopher B Buck
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4263, USA
    J Virol 78:751-7. 2004
    ..The results suggest that the intracellular assembly of papillomavirus structural proteins around heterologous reporter plasmids is surprisingly promiscuous and may be driven primarily by a size discrimination mechanism...
  6. ncbi Biological activities and molecular targets of the human papillomavirus E7 oncoprotein
    K Munger
    Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 20:7888-98. 2001
    ..The transforming activities of E7 largely reflect this important function...
  7. ncbi Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference
    Ming Jiang
    YCR P53 Research Group, Department of Biology, University of York, York YO10 5DD, UK
    Oncogene 21:6041-8. 2002
    ....
  8. pmc Pathogenesis of human papillomaviruses in differentiating epithelia
    Michelle S Longworth
    Department of Microbiology Immunology, The Fineberg Medical School, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    Microbiol Mol Biol Rev 68:362-72. 2004
    ..The characterization of the cellular targets of these viral proteins and the mechanisms regulating the differentiation-dependent viral life cycle remain active areas for the study of these important human pathogens...
  9. ncbi The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    N Dyson
    Cold Spring Harbor Laboratory, NY 11724
    Science 243:934-7. 1989
    ..These results suggest that these three DNA viruses may utilize similar mechanisms in transformation and implicate RB binding as a possible step in human papilloma virus-associated carcinogenesis...
  10. ncbi siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells
    Karin Butz
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, Heidelberg D 69120, Germany
    Oncogene 22:5938-45. 2003
    ..Thus, by sequence-specific targeting of antiapoptotic genes, siRNAs may be developed into novel therapeutics that can efficiently correct the apoptosis deficiency of cancer cells...
  11. pmc Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1
    Thomas Iftner
    Sektion Experimentelle Virologie, Universitatsklinikum Tuebingen, Elfriede Aulhorn Strasse 6, D 72076 Tuebingen, Germany
    EMBO J 21:4741-8. 2002
    ..These data identify a novel link between small DNA tumour viruses and DNA repair pathways, and suggest a novel explanation for the development of genomic instability in tissue cells persistently infected with papillomaviruses...
  12. pmc Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteins
    Tae Woo Kim
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Invest 112:109-17. 2003
    ..Thus, coadministration of DNA vaccines with DNA encoding antiapoptotic proteins represents an innovative approach to enhance DNA vaccine potency...
  13. pmc Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7
    N R Chu
    StressGen Biotechnologies Corporation, Victoria, B C, Canada, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Clin Exp Immunol 121:216-25. 2000
    ..These studies extend previous observations on the induction of cytotoxic T lymphocytes by hsp fusion proteins and are consistent with the clinical application of hspE7 as an immunotherapy for human cervical and anal dysplasia and cancer...
  14. ncbi Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo
    X Y Niu
    Department of Obstetrics and Gynecology, Sichuan University Huaxi the Second Hospital, Chengdu, Sichuan Province, China
    Int J Gynecol Cancer 16:743-51. 2006
    ..RNA interference exists, and the interference to HPV 16 E6 is specific and highly efficient both in vitro and in vivo...
  15. pmc A papillomavirus-like particle (VLP) vaccine displaying HPV16 L2 epitopes induces cross-neutralizing antibodies to HPV11
    Katharina Slupetzky
    Laboratory of Viral Oncology, Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Vaccine 25:2001-10. 2007
    ..Induction of cross-neutralization Ab by L2 epitopes displayed on chimeric VLP represents a possible strategy for the generation of broad-spectrum vaccines to protect against relevant mucosal HPV and associated neoplasia...
  16. ncbi Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies
    Brooke Bishop
    Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 282:31803-11. 2007
    ..On the basis of these distinct surface loop structures, we have provided a molecular explanation for the type specificity of NmAbs against HPV infection...
  17. ncbi Papillomavirus E6 and E7 proteins and their cellular targets
    Trisha M Wise-Draper
    Division of Hematology Oncology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Front Biosci 13:1003-17. 2008
    ..We will summarize here current insights into E6 and E7 interactions with specific cellular targets that stimulate aspects of the viral life cycle, interfere with cell cycle controls and promote carcinogenic processes...
  18. ncbi Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers
    Bassam Abdulkarim
    Laboratoire UPRES EA N degrees 27 10 Radiosensibilité Radiocarcinogénèse humaine and Unité METSI, Institut Gustave Roussy, 94805 Villejuif, France
    Oncogene 21:2334-46. 2002
    ..This study provides the basis for a new anticancer strategy to enhance the antitumor effect of ionizing radiation in HPV-related cancers, without increase deleterious effects...
  19. ncbi alpha(6) Integrin is the main receptor of human papillomavirus type 16 VLP
    C S Yoon
    Genome Research Center, Korea Research Institute of Bioscience and Biotechnology, Taejeon, 305-600, Korea
    Biochem Biophys Res Commun 283:668-73. 2001
    ..The degree of binding of HPV-VLP matched the alpha(6) integrin expression level in cell lines but was not correlated with beta(1) and beta(4) levels, which suggests that alpha(6) integrin is the main receptor of HPV type 16...
  20. ncbi The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability
    Stefan Duensing
    Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 62:7075-82. 2002
    ..Our results therefore suggest that HPV oncoproteins are a source for both numerical and structural chromosome instability during HPV-associated carcinogenesis...
  21. ncbi Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins
    Mako Narisawa-Saito
    Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 98:1505-11. 2007
    ..In the present article, the mechanisms of HPV16 E6- and E7-induced multistep carcinogenesis and recently identified functions of these onco-proteins are reviewed...
  22. pmc Predicting indirect readout effects in protein-DNA interactions
    Yongli Zhang
    Departments of Chemistry and Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 101:8337-41. 2004
    ..The sole exception was traced to differential magnesium ion binding...
  23. pmc Early integration of high copy HPV16 detectable in women with normal and low grade cervical cytology and histology
    S M A Kulmala
    Department of Oral Pathology, Institute of Dentistry, University of Turku, Finland
    J Clin Pathol 59:513-7. 2006
    ....
  24. ncbi In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA
    Mitsuo Yoshinouchi
    Department of Obstetrics and Gynecology, Okayama University Medical School, 700 8558, Okayama, Japan
    Mol Ther 8:762-8. 2003
    ..Our results show HPV E6 siRNA as a candidate for gene-specific therapy for HPV-related cervical cancer...
  25. ncbi TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16
    Uzma A Hasan
    International Agency for Research on Cancer World Health Organization, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    J Immunol 178:3186-97. 2007
    ....
  26. ncbi E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I
    G Hossein Ashrafi
    Institute of Comparative Medicine, Department of Pathological Sciences, Glasgow University, Glasgow G61 1QH, Scotland, UK
    Int J Cancer 113:276-83. 2005
    ..Selective downregulation of cell surface HLA class I molecules may allow the virus to establish infection by avoiding immune clearance of virus-infected cells by both CTLs and NK cells...
  27. ncbi Mechanisms of cell transformation by papillomavirus E5 proteins
    D DiMaio
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Oncogene 20:7866-73. 2001
    ..Further analysis of these unique mechanisms of viral transformation will yield new insight into the regulation of growth factor receptor activity and cellular signal transduction pathways...
  28. ncbi Immunological and clinical responses in women with vulval intraepithelial neoplasia vaccinated with a vaccinia virus encoding human papillomavirus 16/18 oncoproteins
    Emma J Davidson
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Cancer Res 63:6032-41. 2003
    ..Local immune infiltration may be a critical factor in potential responsiveness to vaccine therapy in HPV-associated neoplasia and should be carefully monitored in future placebo-controlled trials of immunotherapy for VIN...
  29. ncbi Uniform distribution of HPV 16 E6 and E7 variants in patients with normal histology, cervical intra-epithelial neoplasia and cervical cancer
    I Nindl
    Department of Gynaecology, Gynaecologic Molecular Biology, Friedrich Schiller University, Jena, Germany
    Int J Cancer 82:203-7. 1999
    ..No statistically significant differences in the prevalence of the E6 or E7 prototype sequences, any variants or multivariants in German women with < or = CIN 1, CIN 2/3 or ICC were found...
  30. ncbi Human papillomavirus 16 E6 polymorphisms in cervical lesions from different European populations and their correlation with human leukocyte antigen class II haplotypes
    I Zehbe
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 94:711-6. 2001
    ..01). This observation may explain why L83V is a risk factor more in Sweden than in the other 2 countries...
  31. pmc Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein
    G Steger
    Institut fur Virologie der Universitat zu Koln, Cologne, Germany
    J Virol 71:50-8. 1997
    ..Our results suggest a dose-dependent regulation of the HPV18 E6/E7 promoter by E2 due to variable occupancy of its binding sites, which have antagonizing effects on the activity of the E6/E7 promoter...
  32. ncbi Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer
    Takuma Fujii
    Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Int J Oncol 29:541-8. 2006
    ..These results indicate that atelocollagen-mediated delivery of siRNA HPV18 E6 and E7 can be used as a novel therapeutic approach for cervical cancer...
  33. pmc The human papillomavirus type 16 E5 protein impairs TRAIL- and FasL-mediated apoptosis in HaCaT cells by different mechanisms
    Kirsten Kabsch
    Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
    J Virol 76:12162-72. 2002
    ..We propose that inhibition of ligand-mediated apoptosis in human keratinocytes is a primary function of the HPV-16 E5 protein needed to prevent apoptosis at early stages of viral infection...
  34. ncbi RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin
    Lisa N Putral
    Cancer Biology Program, CICR, R Wing, Princess Alexandra Hospital, Ipswich Rd, Brisbane, QLD 4102, Australia
    Mol Pharmacol 68:1311-9. 2005
    ..Our results provide strong evidence that loss of E6 and E7 results in increased sensitivity to cisplatin, probably because of increased p53 levels...
  35. pmc Viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleus
    Martin Sapp
    Department of Microbiology and Immunology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    FEBS J 276:7206-16. 2009
    ..This minireview summarizes recent advances in our understanding of cell surface events, internalization and the subsequent intracellular trafficking of papillomaviruses...
  36. pmc Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA
    Viviane Bechtold
    Swiss Institute for Experimental Cancer Research ISREC, 1066 Epalinges, Switzerland
    J Virol 77:2021-8. 2003
    ..Our results, together with those of others, suggest that any effect of the E2 protein on the expression of the E6 and E7 genes during the normal viral life cycle is of secondary importance compared to the function of E2 in replication...
  37. pmc Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein
    S S Lee
    Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 94:6670-5. 1997
    ....
  38. ncbi Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China
    T Li
    Laboratory of Genetics, Beijing Institute for Cancer Research, School of Oncology, Peking University, No. 1 Da Hong Luo Chang St, Beijing 100034, China
    Carcinogenesis 22:929-34. 2001
    ..These results suggest that HVP-16 plays a causative role in the high incidence of esophageal cancer in the Anyang region of CHINA:..
  39. ncbi Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells
    Ni Sima
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, Hubei 430030, PR China
    Gynecol Oncol 106:299-304. 2007
    ....
  40. ncbi Genes involved in cell adhesion, cell motility and mitogenic signaling are altered due to HPV 16 E5 protein expression
    N Kivi
    Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Oncogene 27:2532-41. 2008
    ..These alterations may together lead to inhibition of apoptosis and facilitate the establishment of persistent infection in the epithelium...
  41. ncbi Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts
    N Hafner
    Frauenklinik der Friedrich Schiller Universität, Jena, Germany
    Oncogene 27:1610-7. 2008
    ..Instead, constitutive expression of oncogene transcripts rather than the level of expression appears to be decisive for transformation and the maintenance of the malignant phenotype...
  42. pmc Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
    A Hengstermann
    Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, , Germany
    Proc Natl Acad Sci U S A 98:1218-23. 2001
    ....
  43. pmc Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein
    T Veldman
    Departments of Pathology and Oncology, Georgetown University Medical School, Washington, D.C. 20007, USA
    J Virol 75:4467-72. 2001
    ....
  44. ncbi Neutralization of HPV16, 18, 31, and 58 pseudovirions with antisera induced by immunizing rabbits with synthetic peptides representing segments of the HPV16 minor capsid protein L2 surface region
    Kazunari Kondo
    Center for Pathogen Genomics, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 358:266-72. 2007
    ..The cross-neutralization appears to be correlated with conserved aa sequences among HPV types. The data in this study provide a basis for designing vaccine antigens effective against a broader spectrum of the high-risk HPVs...
  45. ncbi Induction of cell death in human papillomavirus 18-positive cervical cancer cells by E6 siRNA
    K Yamato
    Molecular Cellular Oncology and Microbiology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Gene Ther 13:234-41. 2006
    ....
  46. pmc Arrangement of L2 within the papillomavirus capsid
    Christopher B Buck
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 5624, USA
    J Virol 82:5190-7. 2008
    ..This structural information should facilitate investigation of L2 function during the assembly and entry phases of the papillomavirus life cycle...
  47. ncbi p53 codon 72 polymorphism and various human papillomavirus 16 E6 genotypes are risk factors for cervical cancer development
    I Zehbe
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 61:608-11. 2001
    ..Moreover, the frequency of the arginine allele was similar in groups with different E6 genotypes. It is concluded that p53 arginine is a risk factor for cervical cancer but probably acts independently of E6 variants...
  48. pmc Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccines
    Christina Schellenbacher
    Laboratory of Viral Oncology, Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University Vienna, Austria
    J Virol 83:10085-95. 2009
    ....
  49. pmc Mechanisms of human papillomavirus-induced oncogenesis
    Karl Munger
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, NRB 0958C, Boston, MA 02115 5727, USA
    J Virol 78:11451-60. 2004
  50. pmc Chimeric human papillomavirus type 16 (HPV-16) L1 particles presenting the common neutralizing epitope for the L2 minor capsid protein of HPV-6 and HPV-16
    Arvind Varsani
    Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa and Department of Pathology, The Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    J Virol 77:8386-93. 2003
    ..Moreover, it contributes to knowledge of the structure of HPV-16 L1 VLPs and their derivatives...
  51. ncbi HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cells
    F A Suprynowicz
    Department of Pathology, Georgetown University Medical School, Washington, DC 20057, USA
    Oncogene 27:1071-8. 2008
    ..Finally, the upregulation of caveolin-1 and ganglioside GM1 at the plasma membrane of E5-expressing cervical cells provides potential new therapeutic targets and diagnostic markers for high-risk HPV infections...
  52. pmc Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130
    K Smith-McCune
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco CA 94115, USA
    Proc Natl Acad Sci U S A 96:6999-7004. 1999
    ..Induction of E7 function was not correlated with binding to p130 or pRb but rather with intranuclear localization and modest induction of binding to p107...
  53. doi Human papillomavirus type 16 L1E7 chimeric capsomeres have prophylactic and therapeutic efficacy against papillomavirus in mice
    Tao Bian
    Biotech Center for Viral Disease Emergency, Yingxin Street 100, Xuanwu District, Beijing 100052, People s Republic of China
    Mol Cancer Ther 7:1329-35. 2008
    ..Chimeric capsomeres are capable of preventing and eliminating HPV16 infection. Therefore, our study has provided an economical vaccine candidate...
  54. ncbi The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptors
    P Martin
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892
    Cell 59:21-32. 1989
    ..We conclude that E5 may enhance the receptor activity via inhibition of receptor down-modulation...
  55. ncbi Functional significance of sequence variation in the E2 gene and the long control region of human papillomavirus type 16
    G Veress
    Department of Microbiology, University Medical School of Debrecen, Hungary
    J Gen Virol 80:1035-43. 1999
    ..The transcriptional transactivation potentials of the HPV-16 E2 isolates differed only slightly from each other, and the differences seemed to be independent of the taxonomic position of the isolates...
  56. pmc Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
    S Nakagawa
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855, USA
    Mol Cell Biol 20:8244-53. 2000
    ....
  57. ncbi The bovine papillomavirus oncoprotein E5 retains MHC class I molecules in the Golgi apparatus and prevents their transport to the cell surface
    Barbara Marchetti
    Institute of Comparative Medicine, Glasgow University Veterinary School, Garscube Estate, Glasgow G61 1QH, UK
    Oncogene 21:7808-16. 2002
    ..Lack of surface MHC I would have profound consequences for presentation of viral peptides to the immune system...
  58. ncbi Ubiquitous presence of E6 and E7 transcripts in human papillomavirus-positive cervical carcinomas regardless of its type
    S Nakagawa
    Department of Obstetrics and Gynecology, University of Tokyo, Faculty of Medicine, Bunkyo ku, Tokyo, Japan
    J Med Virol 62:251-8. 2000
    ..Thus, the present study demonstrates that E6 and E7 transcripts of HPV exist in virtually all HPV-positive cervical neoplasia specimens except for the absence of E7 transcripts in some of CINs...
  59. pmc Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer
    Hugo Arias-Pulido
    Department of Molecular Genetics and Microbiology, School of Medicine, Health Sciences Center, University of New Mexico, Albuquerque, NM 87111, USA
    J Clin Microbiol 44:1755-62. 2006
    ..HPV-16 E2 expressed from intact episomes may act in trans to regulate integrated genome expression of E6 and E7...
  60. ncbi Effect of preexisting neutralizing antibodies on the anti-tumor immune response induced by chimeric human papillomavirus virus-like particle vaccines
    D M Da Silva
    Cancer Immunology Program, Cardinal Bernardin Cancer Center, Department of Microbiology and Immunology, Loyola University Chicago, 2160 South First Avenue, Maywood, Illinois 60153, USA
    Virology 290:350-60. 2001
    ..This limitation could potentially be overcome by boosting with cVLPs containing the same target antigen incorporated into other papillomavirus-type VLPs...
  61. pmc Viral oncoproteins target the DNA methyltransferases
    W A Burgers
    Wellcome Trust CRUK Gurdon Institute, University of Cambridge, Cambridge, UK
    Oncogene 26:1650-5. 2007
    ..These observations open up the possibility that this association may be used to control cellular proliferation pathways and suggest a new mechanism by which small DNA tumour viruses can steer cells through the cell cycle...
  62. ncbi The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis
    Maria Filippova
    Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, California 92354, USA
    J Biol Chem 279:25729-44. 2004
    ..These results support a model in which E6-mediated degradation of FADD prevents transmission of apoptotic signals via the Fas pathway...
  63. ncbi HPV episomal copy number closely correlates with cell size in keratinocyte monolayer cultures
    Peggy A Garner-Hamrick
    Genomics ID, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    Virology 301:334-41. 2002
    ..The results also indicate that simple monolayer cultures may be useful for studying the relationship between differentiation, HPV DNA replication, and cell-cycle events...
  64. ncbi A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA
    Jacob A Glahder
    The DNA Tumour Virus Group, Institute of Molecular Pathology, The Protein Laboratory, University of Copenhagen, Panum Institute, Bldg 6 2, Blegdamsvej 3C, DK 2200 Copenhagen N, Denmark
    J Gen Virol 84:3429-41. 2003
    ..In conclusion, we have found that P542 is a relatively weak promoter compared with P97 and may be downregulated in differentiated epithelial cells...
  65. pmc Overlapping and independent structural roles for human papillomavirus type 16 L2 conserved cysteines
    Michael J Conway
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Virology 393:295-303. 2009
    ..These results suggest that Cys28 is necessary for late-stage stabilization of capsids, while Cys22 is necessary for proper display of L2 neutralizing epitopes...
  66. pmc Biology of human papillomaviruses
    H R McMurray
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Int J Exp Pathol 82:15-33. 2001
    ..While the mechanisms of action of the viral proteins are not completely understood, researchers are making progress and this article strives to bring together the conclusions from some of this work...
  67. ncbi Comparative analysis of the intracellular location of the high- and low-risk human papillomavirus oncoproteins
    Ernesto Guccione
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    Virology 293:20-5. 2002
    ..These results demonstrate fundamental differences in the localization of these viral oncoproteins within the cell and offer alternative explanations for their respective differences in pathology...
  68. doi Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma
    Francoise Thierry
    Institute of Medical Biology, Singapore, Singapore
    Virology 384:375-9. 2009
    ..We will describe the role played by the viral E2 proteins in the transcriptional repression of the high risk HPV oncogenes and its implication in cervical cancer...
  69. ncbi Induction of human papilloma virus E6/E7-specific cytotoxic T-lymphocyte activity in immune-tolerant, E6/E7-transgenic mice
    A Riezebos-Brilman
    Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen UMCG, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Gene Ther 12:1410-4. 2005
    ..We demonstrate that, depending on the route of immunization, SFV-expressing HPV16 E6 and E7 indeed has the capacity to induce HPV16 E7-specific cytotoxic T cells in HPV-transgenic mice...
  70. pmc HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes
    Benyue Zhang
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Oncogene 24:2585-8. 2005
    ..This novel result suggests that HPV16 E5 may, at least in part, upregulate EGFR-mediated signal transduction by inhibiting the interaction of c-Cbl with the EGFR, thereby decreasing c-Cbl-mediated degradation of the EGFR...
  71. ncbi Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene
    Sybil M Genther Williams
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 65:6534-42. 2005
    ..Through the analysis of these mice, we show a requirement of the epidermal growth factor receptor for the hyperplastic properties of E5...
  72. ncbi CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2
    Bornali Bhattacharjee
    Human Genetics Unit, Indian Statistical Institute, 203, B T Road, Kolkata 700 108, India
    Virology 354:280-5. 2006
    ..These results indicate the involvement of E2 binding site methylation in presence of intact E2, leading to loss of E2 repressor activity in CaCx...
  73. pmc Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes
    M Nees
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA
    J Virol 75:4283-96. 2001
    ..Thus, high-level expression of the HPV-16 E6 protein in differentiating keratinocytes directly alters expression of genes that influence host resistance to infection and immune function...
  74. ncbi Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development
    H Pan
    Department of Anatomy, University of Wisconsin Medical School, Madison 53706, USA
    Genes Dev 9:2157-69. 1995
    ....
  75. ncbi Phase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia
    Sophie Hallez
    Chimie Biologique, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium
    Cancer Immunol Immunother 53:642-50. 2004
    ....
  76. pmc Global effects of human papillomavirus type 18 E6/E7 in an organotypic keratinocyte culture system
    Peggy A Garner-Hamrick
    Genomics ID, Pharmacia Corp, Kalamazoo, Michigan, USA
    J Virol 78:9041-50. 2004
    ..Our study provides a systematic description of transcript changes brought about by HPV-18 E6/E7 in a physiologically relevant model and should furnish a solid source of information to guide future studies...
  77. ncbi Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosis
    Stephanie Blachon
    Unité Expression Génétique et Maladies, CNRS FRE 2850, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:36088-98. 2005
    ..We speculate that disruption of the E2 gene during viral genome integration in cervical carcinoma provides a means to avoid E2-induced apoptosis and allow initiation of carcinogenesis...
  78. pmc Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites
    S T Oh
    Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Virol 75:5559-66. 2001
    ..This indicates that it is the combinatorial binding of factors to Myc and Sp1 cis elements that is responsible for hTERT induction by E6...
  79. ncbi Integrated human papillomavirus types 52 and 58 are infrequently found in cervical cancer, and high viral loads predict risk of cervical cancer
    Chih Ming Ho
    Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan, ROC
    Gynecol Oncol 102:54-60. 2006
    ..The aim of this prospective study was to analyze whether integration or high viral loads of human papillomavirus (HPV) is essential for malignant transformation of HPV types 52 and 58 as well as types 16 and 18...
  80. ncbi Association of human papillomavirus types 16 and 18 E6 proteins with p53
    B A Werness
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892
    Science 248:76-9. 1990
    ....
  81. ncbi Transcriptional activity among high and low risk human papillomavirus E2 proteins correlates with E2 DNA binding
    Samuel Y Hou
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 277:45619-29. 2002
    ....
  82. ncbi The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein
    Xuefeng Liu
    Department of Pathology and Oncology, Georgetown University Medical School, 3900 Reservoir Rd NW, Washington, DC 20057, USA
    J Biol Chem 280:10807-16. 2005
    ....
  83. ncbi Human papillomavirus: E6 and E7 oncogenes
    Gaëlle Boulet
    AMBIOR, Laboratory for Cell Biology and Histology, University of Antwerp, Groenenborgerlaan 171, BE 2020 Antwerp, Belgium
    Int J Biochem Cell Biol 39:2006-11. 2007
    ..Although prophylactic vaccines are available, further understanding of the viral life cycle and the mechanisms underlying HPV-induced oncogenesis is necessary to face the many challenges in the field of HPV and cancer...
  84. ncbi Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2
    Diana V Pastrana
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
    Virology 337:365-72. 2005
    ..BPV1 L2 was exceptionally effective at inducing cross-neutralizing antibodies to these shared epitopes...
  85. pmc Stable replication of papillomavirus genomes in Saccharomyces cerevisiae
    Peter C Angeletti
    McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
    J Virol 76:3350-8. 2002
    ....
  86. pmc Production of human papillomavirus type 16 virus-like particles in transgenic plants
    Sophia Biemelt
    Institut fur Pflanzengenetik und Kulturpflanzenforschung, 06466 Gatersleben, Germany
    J Virol 77:9211-20. 2003
    ..Our data, however, indicate that an anti-L1 response was primed in about half of the 24 animals...
  87. pmc The E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16- or type 18-positive cervical cancer cell lines via translation reinitiation
    Shuang Tang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI NIH, 10 Center Dr, Rm 10 S255, MSC 1868, Bethesda, Maryland 20892 1868, USA
    J Virol 80:4249-63. 2006
    ..The data thus provide direct evidence that the E6*I mRNAs of high-risk HPVs are responsible for E7 production...
  88. ncbi Retinoic acid-mediated G1-S-phase arrest of normal human mammary epithelial cells is independent of the level of p53 protein expression
    V L Seewaldt
    Department of Medicine, University of Washington, Seattle, USA
    Cell Growth Differ 10:49-59. 1999
    ..Our results emphasize the chemotherapeutic potential of ATRA and antiestrogens, particularly for suppressing the growth of tumors lacking functional p53...
  89. ncbi Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activity
    Wen Jun Liu
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
    Virology 301:43-52. 2002
    ..However, this may be insufficient for priming E7 responses in animals with split tolerance to E7 as a consequence of expression of E7 in somatic cells...
  90. ncbi Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein
    J J Chen
    Department of Dermatology, New England Medical Center, Boston, MA, USA
    Science 269:529-31. 1995
    ..The transforming activity of BPV-1 E6 mutants correlated with their E6BP-binding ability. E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum...
  91. ncbi Mutational analysis of human papillomavirus type 16 major capsid protein L1: the cysteines affecting the intermolecular bonding and structure of L1-capsids
    Yoshiyuki Ishii
    Division of Molecular Genetics, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 308:128-36. 2003
    ....
  92. pmc Ubiquitin-fused and/or multiple early genes from cottontail rabbit papillomavirus as DNA vaccines
    Sancy A Leachman
    Department of Dermatology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    J Virol 76:7616-24. 2002
    ..This last vaccine prevented papilloma formation at all challenge sites in all rabbits, demonstrating complete protection...
  93. pmc Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunity
    Balasubramanyam Karanam
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21231, USA
    Vaccine 27:1040-9. 2009
    ....
  94. doi Construction and characterization of recombinant fowlpox viruses expressing human papilloma virus E6 and E7 oncoproteins
    Eleana Pozzi
    Department of Medical Pharmacology, University of Milan, Milan, Italy
    J Virol Methods 158:184-9. 2009
    ..The results indicate that FPV recombinants can express correctly the E6 and E7 oncoproteins, and they should represent appropriate vectors for the expression of these oncoproteins in human cells...
  95. ncbi A Phase 1 study of a recombinant viruslike particle vaccine against human papillomavirus type 11 in healthy adult volunteers
    T G Evans
    Infectious Diseases Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Infect Dis 183:1485-93. 2001
    ..This candidate HPV VLP vaccine induced robust B and T cell responses, and T cell helper epitopes appear to be conserved across HPV types...
  96. ncbi Oligomerization of the E5 protein of human papillomavirus type 16 occurs through multiple hydrophobic regions
    Christine E Gieswein
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    Virology 313:415-26. 2003
    ..The majority of E5 expressed in HEK 293-T7 cells was perinuclear but did not appear to localize to the cis/medial-Golgi, in contrast to previous reports for both HPV16 E5 and BPV1 E5...
  97. ncbi Synthetic peptides induce a cytotoxic response against human papillomavirus type-18
    M R Castellanos
    Department of Medicine, Nalitt Institute for Cancer and Blood Related Diseases, Staten Island, New York, 10305, USA
    Gynecol Oncol 82:77-83. 2001
    ..These two epitopes are candidates for a peptide-based vaccine against HPV-18(+) tumors. The model described has broad applications and can be used in the development of immunotherapy for other types of cancers...
  98. ncbi A novel human papillomavirus type 6 neutralizing domain comprising two discrete regions of the major capsid protein L1
    W L McClements
    Department of Virus and Cell Biology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Virology 289:262-8. 2001
    ..This suggests that clusters of diverged residues, surrounded by conserved L1 sequences, are presented on the surface of assembled particles and are responsible for eliciting critical humoral immune responses to the virus...
  99. ncbi Codon optimized expression of HPV 16 E6 renders target cells susceptible to E6-specific CTL recognition
    Regina Samorski
    Deutsches Krebsforschungszentrum, Heidelberg, Forschungsschwerpunkt Infektionen und Krebs, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
    Immunol Lett 107:41-9. 2006
    ..Both findings are of potential relevance for the design of tumor vaccines...
  100. ncbi Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres
    E C Goodwin
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell Growth Differ 12:525-34. 2001
    ..Cells carrying the hTERT gene and control cells displayed identical responses to E2 expression. Therefore, HeLa cell senescence induced by HPV repression is not triggered by short telomeres or low levels of telomerase activity...
  101. ncbi Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancer
    Katsuyuki Hamada
    Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Shitsukawa, Toon, Ehime 791 0295, Japan
    Gynecol Oncol 103:820-30. 2006
    ..We are exploring the potential use of antisense HPV RNA transcripts for gene therapy for HPV-positive cervical cancers...

Research Grants136 found, 100 shown here

  1. Predoctoral Training Program in Virology
    Peter Tattersall; Fiscal Year: 2007
    ..abstract_text> ..
  2. Genomic instability induced by the HPV-16 E7 oncoprotein
    Stefan Duensing; Fiscal Year: 2009
    ....
  3. Genomic instability induced by the HPV-16 E7 oncoprotein
    Stefan Duensing; Fiscal Year: 2006
    ....
  4. Genomic instability induced by the HPV-16 E7 oncoprotein
    Stefan Duensing; Fiscal Year: 2008
    ....
  5. Genomic instability induced by the HPV-16 E7 oncoprotein
    Stefan Duensing; Fiscal Year: 2005
    ....
  6. Genomic instability induced by the HPV-16 E7 oncoprotein
    Stefan Duensing; Fiscal Year: 2007
    ....
  7. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2005
    ..abstract_text> ..
  8. A Phase I/II Trial of a Therapeutic HPV Vaccine
    Cornelia Trimble; Fiscal Year: 2004
    ....
  9. Therapeutic HPV vaccination for stage IB1 cervical cancer
    Cornelia Trimble; Fiscal Year: 2008
    ..Clinical grade vaccine has been manufactured by NCI RAID, in collaboration with PowderMed. This trial is a SPORE-GOG collaboration. ..
  10. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2002
    ..abstract_text> ..
  11. Dendritic Cell Immunotherapy for Cervical Cancer
    Alessandro Santin; Fiscal Year: 2004
    ..This study will determine whether E7 antigen-loaded autologous DC vaccination offers the potential of therapeutic benefit for patients with HPV16 or HPV18-associated cervical cancer. ..
  12. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2006
    ..abstract_text> ..
  13. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2002
    ..abstract_text> ..
  14. Seroepidemiologic Study of HPV and Oral Cancer
    Elaine Smith; Fiscal Year: 2002
    ..abstract_text> ..
  15. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2004
    ..abstract_text> ..
  16. CYTOTOXIC T LYMPHOCYTE RESPONSE TO HPV 16
    Mayumi Nakagawa; Fiscal Year: 2002
    ....
  17. THERAPEUTIC VACCINES FOR HPV DISEASES
    Cornelia Trimble; Fiscal Year: 2005
    ..These facilities will be used to develop Dr. Trimble's ability to design and execute clinical trials evaluating preneoplastic HPV-associated lesions of the female lower genital tract. ..
  18. Mechanisms of mucosal immune evasion in high grade cervical dysplasia
    Cornelia L Trimble; Fiscal Year: 2010
    ....
  19. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2007
    ..abstract_text> ..
  20. Understanding and Enhancing T-Cell Responses to high Risk Human Papillomaviruses
    Mayumi Nakagawa; Fiscal Year: 2010
    ..In addition, this project has the potential for developing a novel adjuvant capable of enhancing peptide vaccine immunogenicity, which can be applied to other cancers as well as other infectious agents. ..
  21. International Collaborative HNC Research
    Elaine Smith; Fiscal Year: 2007
    ..This aim is to determine whether there is an easily administered, sensitive biomarker that can predict HPV-HR status in HNC tumors prior to therapy.. [unreadable] [unreadable] [unreadable]..
  22. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2003
    ..abstract_text> ..
  23. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 1999
    ..abstract_text> ..
  24. Treatment of Chemotherapy-Resistant Human Ovarian Cancer by Administration of CPE
    Alessandro Santin; Fiscal Year: 2008
    ..Results of the proposed research will lay the foundation for rapid clinical translation of an innovative, potentially highly effective treatment for patients with chemotherapy-resistant ovarian cancer. ..
  25. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2001
    ..abstract_text> ..
  26. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2008
    ..abstract_text> ..
  27. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2000
    ..abstract_text> ..
  28. Therapeutic DNA-MVA prime boost vaccination for HPV disease
    Cornelia Trimble; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. VSV-based Therapeutic Papilloma Vaccine
    Janet Brandsma; Fiscal Year: 2004
    ..The data provided by this investigation are likely to aid in the development a highly effective HPV vaccine to protect women against cervical cancer. ..
  30. ANALYSIS OF THE PDGF RECEPTOR JUXTAMEMBRANE DOMAIN
    Daniel DiMaio; Fiscal Year: 2004
    ..These experiments should provide new insights into the function and regulation of receptor tyrosine kinases and into human tumorigenesis, and they should elucidate the binding properties of a new family of WW domains. ..
  31. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2008
    ..abstract_text> ..
  32. VSV-based Therapeutic Papilloma Vaccine
    Janet Brandsma; Fiscal Year: 2003
    ..The data provided by this investigation are likely to aid in the development a highly effective HPV vaccine to protect women against cervical cancer. ..
  33. ANALYSIS OF THE PDGF RECEPTOR JUXTAMEMBRANE DOMAIN
    Daniel DiMaio; Fiscal Year: 2000
    ..These experiments should provide new insights into the function and regulation of receptor tyrosine kinases and into human tumorigenesis, and they should elucidate the binding properties of a new family of WW domains. ..
  34. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2009
    ..abstract_text> ..
  35. Role of HPV16 E7/E2F6 interaction in viral oncogenesis
    Margaret McLaughlin Drubin; Fiscal Year: 2006
    ..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  36. A tri-antigen nasal anthrax vaccine against toxins and vegetative bacilli
    Zhengrong Cui; Fiscal Year: 2007
    ..The same vaccine or its modified version can also be used in agricultural industries to vaccinate cattle. [unreadable] [unreadable] [unreadable]..
  37. VSV-based Therapeutic Papilloma Vaccine
    Janet Brandsma; Fiscal Year: 2006
    ..The data provided by this investigation are likely to aid in the development a highly effective HPV vaccine to protect women against cervical cancer. ..
  38. Activation of NF-kB by Human Papillomaviruses
    CRAIG WOODWORTH; Fiscal Year: 2006
    ..Therefore, our results will provide basic information on how HPV might alter host response to infection. [unreadable] [unreadable]..
  39. VSV-based Therapeutic Papilloma Vaccine
    Janet Brandsma; Fiscal Year: 2007
    ..The data provided by this investigation are likely to aid in the development a highly effective HPV vaccine to protect women against cervical cancer. ..
  40. Regulation of Telomerase by NFX1
    Rachel Katzenellenbogen; Fiscal Year: 2008
    ....
  41. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 2008
    ..abstract_text> ..
  42. MOLECULAR BASIS OF VIRAL AND CELLULAR TRANSFORMATION
    Daniel DiMaio; Fiscal Year: 2008
    ..This Program represents the significant commitment of the Yale University School of Medicine and the participating investigators to studies that will have direct relevance to understanding the cause of human cancer. ..
  43. VSV-based Therapeutic Papilloma Vaccine
    Janet Brandsma; Fiscal Year: 2005
    ..The data provided by this investigation are likely to aid in the development a highly effective HPV vaccine to protect women against cervical cancer. ..
  44. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2007
    ..abstract_text> ..
  45. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 2007
    ..abstract_text> ..
  46. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 2004
    ..abstract_text> ..
  47. ANALYSIS OF THE PDGF RECEPTOR JUXTAMEMBRANE DOMAIN
    Daniel DiMaio; Fiscal Year: 2003
    ..These experiments should provide new insights into the function and regulation of receptor tyrosine kinases and into human tumorigenesis, and they should elucidate the binding properties of a new family of WW domains. ..
  48. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2002
    ..PDGF beta receptor, 5) to test the hypothesis that certain mutants of E5 can interfere with PDGF beta signaling and 6) to identify novel peptide sequences that can contribute to the multimerization and activation of PDGF beta receptor ..
  49. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 2001
    ..Defining the major protective viral epitopes on PV virions and on the early viral proteins in papillomavirus-infected cells will be key to planning effective immunotherapeutic management of this infectious disease. ..
  50. ANALYSIS OF THE PDGF RECEPTOR JUXTAMEMBRANE DOMAIN
    Daniel DiMaio; Fiscal Year: 2002
    ..These experiments should provide new insights into the function and regulation of receptor tyrosine kinases and into human tumorigenesis, and they should elucidate the binding properties of a new family of WW domains. ..
  51. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2010
    ..In addition, on the basis of these studies, we will continue to develop a novel protein engineering method to control biological processes, including infection by human immunodeficiency virus, an important co-factor in many cancers. ..
  52. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 2005
    ..abstract_text> ..
  53. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 2002
    ..Defining the major protective viral epitopes on PV virions and on the early viral proteins in papillomavirus-infected cells will be key to planning effective immunotherapeutic management of this infectious disease. ..
  54. ANALYSIS OF CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 1991
    ..Because of the association of papillomavirus with human carcinomas, our findings may be relevant to understanding the genesis of human cancers...
  55. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2003
    ..PDGF beta receptor, 5) to test the hypothesis that certain mutants of E5 can interfere with PDGF beta signaling and 6) to identify novel peptide sequences that can contribute to the multimerization and activation of PDGF beta receptor ..
  56. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2001
    ..PDGF beta receptor, 5) to test the hypothesis that certain mutants of E5 can interfere with PDGF beta signaling and 6) to identify novel peptide sequences that can contribute to the multimerization and activation of PDGF beta receptor ..
  57. MOLECULAR BASIS OF VIRAL AND CELLULAR TRANSFORMATION
    Daniel DiMaio; Fiscal Year: 2008
    ..This Program represents the significant commitment of the Yale University School of Medicine and the participating investigators to studies that will have direct relevance to understanding the cause of human cancer. ..
  58. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 2006
    ..abstract_text> ..
  59. H PYLORI RECOMBINATION AND GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 1999
    ..pylori infections. ..
  60. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2001
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  61. Development of furanones for treatment of anthrax
    Martin Blaser; Fiscal Year: 2005
    ..In initial studies, spores will be given subcutaneosly. Efficacy parameters will be defined as above. Successful trials can lead to phase I studies in humans, and treatment studies in non-human primates. ..
  62. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 1999
    ..Defining the major protective viral epitopes on PV virions and on the early viral proteins in papillomavirus-infected cells will be key to planning effective immunotherapeutic management of this infectious disease. ..
  63. Mathematical models of H. pylori gastric colonization
    Martin Blaser; Fiscal Year: 2007
    ..The experimental results will enable development of deterministic models relating genotypic and phenotypic variation with selection. [unreadable] [unreadable]..
  64. Cell surface events of human papillomavirus type 16 and 18 infection
    Martin Sapp; Fiscal Year: 2010
    ..This should allow identification of cellular targets for drug therapies to prevent HPV induced cancers. ..
  65. Mathematical models of H. pylori gastric colonization
    Martin J Blaser; Fiscal Year: 2010
    ..Including mathematical analyses in these studies also permits a generalization of the principles and their applications to other microbes involved in human health and disease. ..
  66. PAPILLOMAVIRUS HOST INTERACTION
    Neil Christensen; Fiscal Year: 2000
    ..Defining the major protective viral epitopes on PV virions and on the early viral proteins in papillomavirus-infected cells will be key to planning effective immunotherapeutic management of this infectious disease. ..
  67. Disappearing gastrointestinal microbiota in epidemic obesity.
    Martin J Blaser; Fiscal Year: 2010
    ..We will focus on both maternal and antibiotic effects on the composition of the gastric and colonic bacterial populations, and their metabolic effects. ..
  68. Mechanisms of the Adenovirus E4-ORF1 Oncoprotein
    Ronald T Javier; Fiscal Year: 2011
    ....
  69. Mathematical models of H. pylori gastric colonization
    Martin Blaser; Fiscal Year: 2008
    ..The experimental results will enable development of deterministic models relating genotypic and phenotypic variation with selection. [unreadable] [unreadable]..
  70. H PYLORI RECOMBINATION AND GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2000
    ..pylori infections. ..
  71. H PYLORI RECOMBINATION AND GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2001
    ..pylori infections. ..
  72. MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2002
    ..3) To examine the effect of recombination between two different H.pylori strains during experimental infections, and to develop representative mathematical models for this more complex phenomenon. ..
  73. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2003
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  74. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2002
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  75. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2004
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  76. Cell surface events of human papillomavirus type 16 and 18 infection
    Martin Sapp; Fiscal Year: 2009
    ..This should allow identification of cellular targets for drug therapies to prevent HPV induced cancers. ..
  77. Diindolylmethane enhances the efficacy of preventive vaccines in an HPV transgeni
    Daniel Sepkovic; Fiscal Year: 2009
    ..These women are at increased risk for cervical cancer. Our goal is to adapt preventive and therapeutic vaccines so that they can be used in this at risk population. ..
  78. Role of the Human Cytomegalovirus UL97 Proein Kinase in Viral Replication
    JEREMY KAMIL; Fiscal Year: 2008
    ..S. population, this research also offers to contribute to a better understanding of an important therapeutic drug target. ..
  79. li Suppression-enhanced HIV DNA Vaccine
    Minzhen Xu; Fiscal Year: 2003
    ..In a Phase II program Ii-RGC/gp120 DNA vaccines will be tested in non-human primates for the induction of a protective immune response against pathogenic HIV infection. ..
  80. RSV Vaccine Development Based on HPV Virus-Like Particles
    Yoshihiko Murata; Fiscal Year: 2008
    ..The proposed project may provide substantial progress towards the development of an RSV vaccine, which remains an unmet medical need. ..
  81. Mechanisms of the Adenovirus E4-ORF1 Oncoprotein
    Ronald T Javier; Fiscal Year: 2010
    ....
  82. Mathematical models of H. pylori gastric colonization
    Martin Blaser; Fiscal Year: 2009
    ..Including mathematical analyses in these studies also permits a generalization of the principles and their applications to other microbes involved in human health and disease. ..
  83. Mathematical models of H. pylori gastric colonization
    Martin Blaser; Fiscal Year: 2006
    ..The experimental results will enable development of deterministic models relating genotypic and phenotypic variation with selection. [unreadable] [unreadable]..
  84. MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2001
    ..3) To examine the effect of recombination between two different H.pylori strains during experimental infections, and to develop representative mathematical models for this more complex phenomenon. ..
  85. Diindolylmethane enhances the efficacy of preventive vaccines in an HPV transgeni
    DANIEL WAYNE SEPKOVIC; Fiscal Year: 2010
    ..These women are at increased risk for cervical cancer. Our goal is to adapt preventive and therapeutic vaccines so that they can be used in this at risk population. ..
  86. HIV li-Key/Peptide Vaccine
    Minzhen Xu; Fiscal Year: 2002
    ..This entirely synthetic vaccine can be manufactured in a large scale and be given to those at high risk of HIV infection. ..
  87. MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2003
    ..3) To examine the effect of recombination between two different H.pylori strains during experimental infections, and to develop representative mathematical models for this more complex phenomenon. ..
  88. HPV Infections in Older Women
    Rachel Winer; Fiscal Year: 2008
    ..This information is important for developing HPV prevention strategies, including vaccine implementation and cervical cancer screening guidelines in populations of older women. ..
  89. Mathematical models of H. pylori gastric colonization
    Martin Blaser; Fiscal Year: 2005
    ..The experimental results will enable development of deterministic models relating genotypic and phenotypic variation with selection. ..
  90. CONTROL OF PAPILLOMAVIRUS EXPRESSION AND TRANSFORMATION
    Elliot Androphy; Fiscal Year: 2009
    ..Understanding how E2 operates will provide insights into the biology of these pathways and infer how aberrations may occur that lead to the development of cancer. ..
  91. CONTROL OF PAPILLOMAVIRUS EXPRESSION AND TRANSFORMATION
    Elliot Androphy; Fiscal Year: 2007
    ..Understanding how E2 operates will provide insights into the biology of these pathways and infer how aberrations may occur that lead to the development of cancer. ..
  92. Small Molecule Inhibitors of Oncogenic Human Papillomavirus
    Elliot Androphy; Fiscal Year: 2009
    ..E6 is necessary for viral replication and for oncogenic progression. These compounds can be advanced to treat cervical, anogenital and head and neck cancers and their precursor lesions. ..
  93. ENHANCING HPV-16 E6-SPECIFIC ANTITUMOR IMMUNITY
    T C Wu; Fiscal Year: 2009
    ..abstract_text> ..
  94. CONTROL OF PAPILLOMAVIRUS EXPRESSION AND TRANSFORMATION
    Elliot Androphy; Fiscal Year: 2008
    ..Understanding how E2 operates will provide insights into the biology of these pathways and infer how aberrations may occur that lead to the development of cancer. ..