Genomes and Genes
viral oncogene proteins
Summary: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
Publications234 found, 100 shown here
- Human papillomavirus is a necessary cause of invasive cervical cancer worldwideJ M Walboomers
Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
J Pathol 189:12-9. 1999..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
- The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53M Scheffner
Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892
Cell 75:495-505. 1993..The ubiquitination of p53 requires the E1 enzyme and a novel E2 in mammalian cells, while E3 activity is conferred by the E6-E6-AP complex. Furthermore, E6-AP appears to have ubiquitin-protein ligase activity in the absence of E6...
- Papillomaviruses and cancer: from basic studies to clinical applicationHarald zur Hausen
Deutsches Krebsforschungszentrum, Heidelberg, Germany
Nat Rev Cancer 2:342-50. 2002..Epidemiological studies have underlined that HPVs are the main aetiological factor for cervical cancer. But how has this knowledge been translated into the clinic to allow the prevention, screening and treatment of cervical cancer?..
- Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesisH zur Hausen
Deutsches Krebsforschungszentrum, Heidelberg, Germany
J Natl Cancer Inst 92:690-8. 2000..Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis...
- Efficient intracellular assembly of papillomaviral vectorsChristopher B Buck
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4263, USA
J Virol 78:751-7. 2004..The results suggest that the intracellular assembly of papillomavirus structural proteins around heterologous reporter plasmids is surprisingly promiscuous and may be driven primarily by a size discrimination mechanism...
- Biological activities and molecular targets of the human papillomavirus E7 oncoproteinK Munger
Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, MA 02115, USA
Oncogene 20:7888-98. 2001..The transforming activities of E7 largely reflect this important function...
- Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interferenceMing Jiang
YCR P53 Research Group, Department of Biology, University of York, York YO10 5DD, UK
Oncogene 21:6041-8. 2002....
- Pathogenesis of human papillomaviruses in differentiating epitheliaMichelle S Longworth
Department of Microbiology Immunology, The Fineberg Medical School, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
Microbiol Mol Biol Rev 68:362-72. 2004..The characterization of the cellular targets of these viral proteins and the mechanisms regulating the differentiation-dependent viral life cycle remain active areas for the study of these important human pathogens...
- The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene productN Dyson
Cold Spring Harbor Laboratory, NY 11724
Science 243:934-7. 1989..These results suggest that these three DNA viruses may utilize similar mechanisms in transformation and implicate RB binding as a possible step in human papilloma virus-associated carcinogenesis...
- siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cellsKarin Butz
Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, Heidelberg D 69120, Germany
Oncogene 22:5938-45. 2003..Thus, by sequence-specific targeting of antiapoptotic genes, siRNAs may be developed into novel therapeutics that can efficiently correct the apoptosis deficiency of cancer cells...
- Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1Thomas Iftner
Sektion Experimentelle Virologie, Universitatsklinikum Tuebingen, Elfriede Aulhorn Strasse 6, D 72076 Tuebingen, Germany
EMBO J 21:4741-8. 2002..These data identify a novel link between small DNA tumour viruses and DNA repair pathways, and suggest a novel explanation for the development of genomic instability in tissue cells persistently infected with papillomaviruses...
- Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteinsTae Woo Kim
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Clin Invest 112:109-17. 2003..Thus, coadministration of DNA vaccines with DNA encoding antiapoptotic proteins represents an innovative approach to enhance DNA vaccine potency...
- Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7N R Chu
StressGen Biotechnologies Corporation, Victoria, B C, Canada, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Clin Exp Immunol 121:216-25. 2000..These studies extend previous observations on the induction of cytotoxic T lymphocytes by hsp fusion proteins and are consistent with the clinical application of hspE7 as an immunotherapy for human cervical and anal dysplasia and cancer...
- Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivoX Y Niu
Department of Obstetrics and Gynecology, Sichuan University Huaxi the Second Hospital, Chengdu, Sichuan Province, China
Int J Gynecol Cancer 16:743-51. 2006..RNA interference exists, and the interference to HPV 16 E6 is specific and highly efficient both in vitro and in vivo...
- A papillomavirus-like particle (VLP) vaccine displaying HPV16 L2 epitopes induces cross-neutralizing antibodies to HPV11Katharina Slupetzky
Laboratory of Viral Oncology, Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
Vaccine 25:2001-10. 2007..Induction of cross-neutralization Ab by L2 epitopes displayed on chimeric VLP represents a possible strategy for the generation of broad-spectrum vaccines to protect against relevant mucosal HPV and associated neoplasia...
- Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodiesBrooke Bishop
Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA
J Biol Chem 282:31803-11. 2007..On the basis of these distinct surface loop structures, we have provided a molecular explanation for the type specificity of NmAbs against HPV infection...
- Papillomavirus E6 and E7 proteins and their cellular targetsTrisha M Wise-Draper
Division of Hematology Oncology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Front Biosci 13:1003-17. 2008..We will summarize here current insights into E6 and E7 interactions with specific cellular targets that stimulate aspects of the viral life cycle, interfere with cell cycle controls and promote carcinogenic processes...
- Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancersBassam Abdulkarim
Laboratoire UPRES EA N degrees 27 10 Radiosensibilité Radiocarcinogénèse humaine and Unité METSI, Institut Gustave Roussy, 94805 Villejuif, France
Oncogene 21:2334-46. 2002..This study provides the basis for a new anticancer strategy to enhance the antitumor effect of ionizing radiation in HPV-related cancers, without increase deleterious effects...
- alpha(6) Integrin is the main receptor of human papillomavirus type 16 VLPC S Yoon
Genome Research Center, Korea Research Institute of Bioscience and Biotechnology, Taejeon, 305-600, Korea
Biochem Biophys Res Commun 283:668-73. 2001..The degree of binding of HPV-VLP matched the alpha(6) integrin expression level in cell lines but was not correlated with beta(1) and beta(4) levels, which suggests that alpha(6) integrin is the main receptor of HPV type 16...
- The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instabilityStefan Duensing
Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 62:7075-82. 2002..Our results therefore suggest that HPV oncoproteins are a source for both numerical and structural chromosome instability during HPV-associated carcinogenesis...
- Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteinsMako Narisawa-Saito
Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
Cancer Sci 98:1505-11. 2007..In the present article, the mechanisms of HPV16 E6- and E7-induced multistep carcinogenesis and recently identified functions of these onco-proteins are reviewed...
- Predicting indirect readout effects in protein-DNA interactionsYongli Zhang
Departments of Chemistry and Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA
Proc Natl Acad Sci U S A 101:8337-41. 2004..The sole exception was traced to differential magnesium ion binding...
- Early integration of high copy HPV16 detectable in women with normal and low grade cervical cytology and histologyS M A Kulmala
Department of Oral Pathology, Institute of Dentistry, University of Turku, Finland
J Clin Pathol 59:513-7. 2006....
- In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNAMitsuo Yoshinouchi
Department of Obstetrics and Gynecology, Okayama University Medical School, 700 8558, Okayama, Japan
Mol Ther 8:762-8. 2003..Our results show HPV E6 siRNA as a candidate for gene-specific therapy for HPV-related cervical cancer...
- TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16Uzma A Hasan
International Agency for Research on Cancer World Health Organization, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
J Immunol 178:3186-97. 2007....
- E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class IG Hossein Ashrafi
Institute of Comparative Medicine, Department of Pathological Sciences, Glasgow University, Glasgow G61 1QH, Scotland, UK
Int J Cancer 113:276-83. 2005..Selective downregulation of cell surface HLA class I molecules may allow the virus to establish infection by avoiding immune clearance of virus-infected cells by both CTLs and NK cells...
- Mechanisms of cell transformation by papillomavirus E5 proteinsD DiMaio
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Oncogene 20:7866-73. 2001..Further analysis of these unique mechanisms of viral transformation will yield new insight into the regulation of growth factor receptor activity and cellular signal transduction pathways...
- Immunological and clinical responses in women with vulval intraepithelial neoplasia vaccinated with a vaccinia virus encoding human papillomavirus 16/18 oncoproteinsEmma J Davidson
Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
Cancer Res 63:6032-41. 2003..Local immune infiltration may be a critical factor in potential responsiveness to vaccine therapy in HPV-associated neoplasia and should be carefully monitored in future placebo-controlled trials of immunotherapy for VIN...
- Uniform distribution of HPV 16 E6 and E7 variants in patients with normal histology, cervical intra-epithelial neoplasia and cervical cancerI Nindl
Department of Gynaecology, Gynaecologic Molecular Biology, Friedrich Schiller University, Jena, Germany
Int J Cancer 82:203-7. 1999..No statistically significant differences in the prevalence of the E6 or E7 prototype sequences, any variants or multivariants in German women with < or = CIN 1, CIN 2/3 or ICC were found...
- Human papillomavirus 16 E6 polymorphisms in cervical lesions from different European populations and their correlation with human leukocyte antigen class II haplotypesI Zehbe
Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Int J Cancer 94:711-6. 2001..01). This observation may explain why L83V is a risk factor more in Sweden than in the other 2 countries...
- Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 proteinG Steger
Institut fur Virologie der Universitat zu Koln, Cologne, Germany
J Virol 71:50-8. 1997..Our results suggest a dose-dependent regulation of the HPV18 E6/E7 promoter by E2 due to variable occupancy of its binding sites, which have antagonizing effects on the activity of the E6/E7 promoter...
- Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancerTakuma Fujii
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160 8582, Japan
Int J Oncol 29:541-8. 2006..These results indicate that atelocollagen-mediated delivery of siRNA HPV18 E6 and E7 can be used as a novel therapeutic approach for cervical cancer...
- The human papillomavirus type 16 E5 protein impairs TRAIL- and FasL-mediated apoptosis in HaCaT cells by different mechanismsKirsten Kabsch
Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
J Virol 76:12162-72. 2002..We propose that inhibition of ligand-mediated apoptosis in human keratinocytes is a primary function of the HPV-16 E5 protein needed to prevent apoptosis at early stages of viral infection...
- RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatinLisa N Putral
Cancer Biology Program, CICR, R Wing, Princess Alexandra Hospital, Ipswich Rd, Brisbane, QLD 4102, Australia
Mol Pharmacol 68:1311-9. 2005..Our results provide strong evidence that loss of E6 and E7 results in increased sensitivity to cisplatin, probably because of increased p53 levels...
- Viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleusMartin Sapp
Department of Microbiology and Immunology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
FEBS J 276:7206-16. 2009..This minireview summarizes recent advances in our understanding of cell surface events, internalization and the subsequent intracellular trafficking of papillomaviruses...
- Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNAViviane Bechtold
Swiss Institute for Experimental Cancer Research ISREC, 1066 Epalinges, Switzerland
J Virol 77:2021-8. 2003..Our results, together with those of others, suggest that any effect of the E2 protein on the expression of the E6 and E7 genes during the normal viral life cycle is of secondary importance compared to the function of E2 in replication...
- Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor proteinS S Lee
Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 94:6670-5. 1997....
- Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of ChinaT Li
Laboratory of Genetics, Beijing Institute for Cancer Research, School of Oncology, Peking University, No. 1 Da Hong Luo Chang St, Beijing 100034, China
Carcinogenesis 22:929-34. 2001..These results suggest that HVP-16 plays a causative role in the high incidence of esophageal cancer in the Anyang region of CHINA:..
- Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cellsNi Sima
Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, Hubei 430030, PR China
Gynecol Oncol 106:299-304. 2007....
- Genes involved in cell adhesion, cell motility and mitogenic signaling are altered due to HPV 16 E5 protein expressionN Kivi
Department of Virology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Oncogene 27:2532-41. 2008..These alterations may together lead to inhibition of apoptosis and facilitate the establishment of persistent infection in the epithelium...
- Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcriptsN Hafner
Frauenklinik der Friedrich Schiller Universität, Jena, Germany
Oncogene 27:1610-7. 2008..Instead, constitutive expression of oncogene transcripts rather than the level of expression appears to be decisive for transformation and the maintenance of the malignant phenotype...
- Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cellsA Hengstermann
Institute of Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, , Germany
Proc Natl Acad Sci U S A 98:1218-23. 2001....
- Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoproteinT Veldman
Departments of Pathology and Oncology, Georgetown University Medical School, Washington, D.C. 20007, USA
J Virol 75:4467-72. 2001....
- Neutralization of HPV16, 18, 31, and 58 pseudovirions with antisera induced by immunizing rabbits with synthetic peptides representing segments of the HPV16 minor capsid protein L2 surface regionKazunari Kondo
Center for Pathogen Genomics, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Virology 358:266-72. 2007..The cross-neutralization appears to be correlated with conserved aa sequences among HPV types. The data in this study provide a basis for designing vaccine antigens effective against a broader spectrum of the high-risk HPVs...
- Induction of cell death in human papillomavirus 18-positive cervical cancer cells by E6 siRNAK Yamato
Molecular Cellular Oncology and Microbiology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Cancer Gene Ther 13:234-41. 2006....
- Arrangement of L2 within the papillomavirus capsidChristopher B Buck
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 5624, USA
J Virol 82:5190-7. 2008..This structural information should facilitate investigation of L2 function during the assembly and entry phases of the papillomavirus life cycle...
- p53 codon 72 polymorphism and various human papillomavirus 16 E6 genotypes are risk factors for cervical cancer developmentI Zehbe
Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Cancer Res 61:608-11. 2001..Moreover, the frequency of the arginine allele was similar in groups with different E6 genotypes. It is concluded that p53 arginine is a risk factor for cervical cancer but probably acts independently of E6 variants...
- Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccinesChristina Schellenbacher
Laboratory of Viral Oncology, Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University Vienna, Austria
J Virol 83:10085-95. 2009....
- Mechanisms of human papillomavirus-induced oncogenesisKarl Munger
Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, NRB 0958C, Boston, MA 02115 5727, USA
J Virol 78:11451-60. 2004
- Chimeric human papillomavirus type 16 (HPV-16) L1 particles presenting the common neutralizing epitope for the L2 minor capsid protein of HPV-6 and HPV-16Arvind Varsani
Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa and Department of Pathology, The Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
J Virol 77:8386-93. 2003..Moreover, it contributes to knowledge of the structure of HPV-16 L1 VLPs and their derivatives...
- HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cellsF A Suprynowicz
Department of Pathology, Georgetown University Medical School, Washington, DC 20057, USA
Oncogene 27:1071-8. 2008..Finally, the upregulation of caveolin-1 and ganglioside GM1 at the plasma membrane of E5-expressing cervical cells provides potential new therapeutic targets and diagnostic markers for high-risk HPV infections...
- Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130K Smith-McCune
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco CA 94115, USA
Proc Natl Acad Sci U S A 96:6999-7004. 1999..Induction of E7 function was not correlated with binding to p130 or pRb but rather with intranuclear localization and modest induction of binding to p107...
- Human papillomavirus type 16 L1E7 chimeric capsomeres have prophylactic and therapeutic efficacy against papillomavirus in miceTao Bian
Biotech Center for Viral Disease Emergency, Yingxin Street 100, Xuanwu District, Beijing 100052, People s Republic of China
Mol Cancer Ther 7:1329-35. 2008..Chimeric capsomeres are capable of preventing and eliminating HPV16 infection. Therefore, our study has provided an economical vaccine candidate...
- The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptorsP Martin
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892
Cell 59:21-32. 1989..We conclude that E5 may enhance the receptor activity via inhibition of receptor down-modulation...
- Functional significance of sequence variation in the E2 gene and the long control region of human papillomavirus type 16G Veress
Department of Microbiology, University Medical School of Debrecen, Hungary
J Gen Virol 80:1035-43. 1999..The transcriptional transactivation potentials of the HPV-16 E2 isolates differed only slightly from each other, and the differences seemed to be independent of the taxonomic position of the isolates...
- Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligaseS Nakagawa
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855, USA
Mol Cell Biol 20:8244-53. 2000....
- The bovine papillomavirus oncoprotein E5 retains MHC class I molecules in the Golgi apparatus and prevents their transport to the cell surfaceBarbara Marchetti
Institute of Comparative Medicine, Glasgow University Veterinary School, Garscube Estate, Glasgow G61 1QH, UK
Oncogene 21:7808-16. 2002..Lack of surface MHC I would have profound consequences for presentation of viral peptides to the immune system...
- Ubiquitous presence of E6 and E7 transcripts in human papillomavirus-positive cervical carcinomas regardless of its typeS Nakagawa
Department of Obstetrics and Gynecology, University of Tokyo, Faculty of Medicine, Bunkyo ku, Tokyo, Japan
J Med Virol 62:251-8. 2000..Thus, the present study demonstrates that E6 and E7 transcripts of HPV exist in virtually all HPV-positive cervical neoplasia specimens except for the absence of E7 transcripts in some of CINs...
- Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancerHugo Arias-Pulido
Department of Molecular Genetics and Microbiology, School of Medicine, Health Sciences Center, University of New Mexico, Albuquerque, NM 87111, USA
J Clin Microbiol 44:1755-62. 2006..HPV-16 E2 expressed from intact episomes may act in trans to regulate integrated genome expression of E6 and E7...
- Effect of preexisting neutralizing antibodies on the anti-tumor immune response induced by chimeric human papillomavirus virus-like particle vaccinesD M Da Silva
Cancer Immunology Program, Cardinal Bernardin Cancer Center, Department of Microbiology and Immunology, Loyola University Chicago, 2160 South First Avenue, Maywood, Illinois 60153, USA
Virology 290:350-60. 2001..This limitation could potentially be overcome by boosting with cVLPs containing the same target antigen incorporated into other papillomavirus-type VLPs...
- Viral oncoproteins target the DNA methyltransferasesW A Burgers
Wellcome Trust CRUK Gurdon Institute, University of Cambridge, Cambridge, UK
Oncogene 26:1650-5. 2007..These observations open up the possibility that this association may be used to control cellular proliferation pathways and suggest a new mechanism by which small DNA tumour viruses can steer cells through the cell cycle...
- The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosisMaria Filippova
Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, California 92354, USA
J Biol Chem 279:25729-44. 2004..These results support a model in which E6-mediated degradation of FADD prevents transmission of apoptotic signals via the Fas pathway...
- HPV episomal copy number closely correlates with cell size in keratinocyte monolayer culturesPeggy A Garner-Hamrick
Genomics ID, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
Virology 301:334-41. 2002..The results also indicate that simple monolayer cultures may be useful for studying the relationship between differentiation, HPV DNA replication, and cell-cycle events...
- A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNAJacob A Glahder
The DNA Tumour Virus Group, Institute of Molecular Pathology, The Protein Laboratory, University of Copenhagen, Panum Institute, Bldg 6 2, Blegdamsvej 3C, DK 2200 Copenhagen N, Denmark
J Gen Virol 84:3429-41. 2003..In conclusion, we have found that P542 is a relatively weak promoter compared with P97 and may be downregulated in differentiated epithelial cells...
- Overlapping and independent structural roles for human papillomavirus type 16 L2 conserved cysteinesMichael J Conway
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Virology 393:295-303. 2009..These results suggest that Cys28 is necessary for late-stage stabilization of capsids, while Cys22 is necessary for proper display of L2 neutralizing epitopes...
- Biology of human papillomavirusesH R McMurray
Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
Int J Exp Pathol 82:15-33. 2001..While the mechanisms of action of the viral proteins are not completely understood, researchers are making progress and this article strives to bring together the conclusions from some of this work...
- Comparative analysis of the intracellular location of the high- and low-risk human papillomavirus oncoproteinsErnesto Guccione
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
Virology 293:20-5. 2002..These results demonstrate fundamental differences in the localization of these viral oncoproteins within the cell and offer alternative explanations for their respective differences in pathology...
- Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinomaFrancoise Thierry
Institute of Medical Biology, Singapore, Singapore
Virology 384:375-9. 2009..We will describe the role played by the viral E2 proteins in the transcriptional repression of the high risk HPV oncogenes and its implication in cervical cancer...
- Induction of human papilloma virus E6/E7-specific cytotoxic T-lymphocyte activity in immune-tolerant, E6/E7-transgenic miceA Riezebos-Brilman
Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen UMCG, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
Gene Ther 12:1410-4. 2005..We demonstrate that, depending on the route of immunization, SFV-expressing HPV16 E6 and E7 indeed has the capacity to induce HPV16 E7-specific cytotoxic T cells in HPV-transgenic mice...
- HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytesBenyue Zhang
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
Oncogene 24:2585-8. 2005..This novel result suggests that HPV16 E5 may, at least in part, upregulate EGFR-mediated signal transduction by inhibiting the interaction of c-Cbl with the EGFR, thereby decreasing c-Cbl-mediated degradation of the EGFR...
- Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogeneSybil M Genther Williams
McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Cancer Res 65:6534-42. 2005..Through the analysis of these mice, we show a requirement of the epidermal growth factor receptor for the hyperplastic properties of E5...
- CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2Bornali Bhattacharjee
Human Genetics Unit, Indian Statistical Institute, 203, B T Road, Kolkata 700 108, India
Virology 354:280-5. 2006..These results indicate the involvement of E2 binding site methylation in presence of intact E2, leading to loss of E2 repressor activity in CaCx...
- Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytesM Nees
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA
J Virol 75:4283-96. 2001..Thus, high-level expression of the HPV-16 E6 protein in differentiating keratinocytes directly alters expression of genes that influence host resistance to infection and immune function...
- Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens developmentH Pan
Department of Anatomy, University of Wisconsin Medical School, Madison 53706, USA
Genes Dev 9:2157-69. 1995....
- Phase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasiaSophie Hallez
Chimie Biologique, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium
Cancer Immunol Immunother 53:642-50. 2004....
- Global effects of human papillomavirus type 18 E6/E7 in an organotypic keratinocyte culture systemPeggy A Garner-Hamrick
Genomics ID, Pharmacia Corp, Kalamazoo, Michigan, USA
J Virol 78:9041-50. 2004..Our study provides a systematic description of transcript changes brought about by HPV-18 E6/E7 in a physiologically relevant model and should furnish a solid source of information to guide future studies...
- Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosisStephanie Blachon
Unité Expression Génétique et Maladies, CNRS FRE 2850, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Biol Chem 280:36088-98. 2005..We speculate that disruption of the E2 gene during viral genome integration in cervical carcinoma provides a means to avoid E2-induced apoptosis and allow initiation of carcinogenesis...
- Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sitesS T Oh
Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
J Virol 75:5559-66. 2001..This indicates that it is the combinatorial binding of factors to Myc and Sp1 cis elements that is responsible for hTERT induction by E6...
- Integrated human papillomavirus types 52 and 58 are infrequently found in cervical cancer, and high viral loads predict risk of cervical cancerChih Ming Ho
Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan, ROC
Gynecol Oncol 102:54-60. 2006..The aim of this prospective study was to analyze whether integration or high viral loads of human papillomavirus (HPV) is essential for malignant transformation of HPV types 52 and 58 as well as types 16 and 18...
- Association of human papillomavirus types 16 and 18 E6 proteins with p53B A Werness
Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892
Science 248:76-9. 1990....
- Transcriptional activity among high and low risk human papillomavirus E2 proteins correlates with E2 DNA bindingSamuel Y Hou
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
J Biol Chem 277:45619-29. 2002....
- The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoproteinXuefeng Liu
Department of Pathology and Oncology, Georgetown University Medical School, 3900 Reservoir Rd NW, Washington, DC 20057, USA
J Biol Chem 280:10807-16. 2005....
- Human papillomavirus: E6 and E7 oncogenesGaëlle Boulet
AMBIOR, Laboratory for Cell Biology and Histology, University of Antwerp, Groenenborgerlaan 171, BE 2020 Antwerp, Belgium
Int J Biochem Cell Biol 39:2006-11. 2007..Although prophylactic vaccines are available, further understanding of the viral life cycle and the mechanisms underlying HPV-induced oncogenesis is necessary to face the many challenges in the field of HPV and cancer...
- Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2Diana V Pastrana
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
Virology 337:365-72. 2005..BPV1 L2 was exceptionally effective at inducing cross-neutralizing antibodies to these shared epitopes...
- Stable replication of papillomavirus genomes in Saccharomyces cerevisiaePeter C Angeletti
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
J Virol 76:3350-8. 2002....
- Production of human papillomavirus type 16 virus-like particles in transgenic plantsSophia Biemelt
Institut fur Pflanzengenetik und Kulturpflanzenforschung, 06466 Gatersleben, Germany
J Virol 77:9211-20. 2003..Our data, however, indicate that an anti-L1 response was primed in about half of the 24 animals...
- The E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16- or type 18-positive cervical cancer cell lines via translation reinitiationShuang Tang
HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI NIH, 10 Center Dr, Rm 10 S255, MSC 1868, Bethesda, Maryland 20892 1868, USA
J Virol 80:4249-63. 2006..The data thus provide direct evidence that the E6*I mRNAs of high-risk HPVs are responsible for E7 production...
- Retinoic acid-mediated G1-S-phase arrest of normal human mammary epithelial cells is independent of the level of p53 protein expressionV L Seewaldt
Department of Medicine, University of Washington, Seattle, USA
Cell Growth Differ 10:49-59. 1999..Our results emphasize the chemotherapeutic potential of ATRA and antiestrogens, particularly for suppressing the growth of tumors lacking functional p53...
- Codon modified human papillomavirus type 16 E7 DNA vaccine enhances cytotoxic T-lymphocyte induction and anti-tumour activityWen Jun Liu
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
Virology 301:43-52. 2002..However, this may be insufficient for priming E7 responses in animals with split tolerance to E7 as a consequence of expression of E7 in somatic cells...
- Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding proteinJ J Chen
Department of Dermatology, New England Medical Center, Boston, MA, USA
Science 269:529-31. 1995..The transforming activity of BPV-1 E6 mutants correlated with their E6BP-binding ability. E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum...
- Mutational analysis of human papillomavirus type 16 major capsid protein L1: the cysteines affecting the intermolecular bonding and structure of L1-capsidsYoshiyuki Ishii
Division of Molecular Genetics, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Virology 308:128-36. 2003....
- Ubiquitin-fused and/or multiple early genes from cottontail rabbit papillomavirus as DNA vaccinesSancy A Leachman
Department of Dermatology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
J Virol 76:7616-24. 2002..This last vaccine prevented papilloma formation at all challenge sites in all rabbits, demonstrating complete protection...
- Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunityBalasubramanyam Karanam
Department of Pathology, The Johns Hopkins University, Baltimore, MD 21231, USA
Vaccine 27:1040-9. 2009....
- Construction and characterization of recombinant fowlpox viruses expressing human papilloma virus E6 and E7 oncoproteinsEleana Pozzi
Department of Medical Pharmacology, University of Milan, Milan, Italy
J Virol Methods 158:184-9. 2009..The results indicate that FPV recombinants can express correctly the E6 and E7 oncoproteins, and they should represent appropriate vectors for the expression of these oncoproteins in human cells...
- A Phase 1 study of a recombinant viruslike particle vaccine against human papillomavirus type 11 in healthy adult volunteersT G Evans
Infectious Diseases Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Infect Dis 183:1485-93. 2001..This candidate HPV VLP vaccine induced robust B and T cell responses, and T cell helper epitopes appear to be conserved across HPV types...
- Oligomerization of the E5 protein of human papillomavirus type 16 occurs through multiple hydrophobic regionsChristine E Gieswein
Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
Virology 313:415-26. 2003..The majority of E5 expressed in HEK 293-T7 cells was perinuclear but did not appear to localize to the cis/medial-Golgi, in contrast to previous reports for both HPV16 E5 and BPV1 E5...
- Synthetic peptides induce a cytotoxic response against human papillomavirus type-18M R Castellanos
Department of Medicine, Nalitt Institute for Cancer and Blood Related Diseases, Staten Island, New York, 10305, USA
Gynecol Oncol 82:77-83. 2001..These two epitopes are candidates for a peptide-based vaccine against HPV-18(+) tumors. The model described has broad applications and can be used in the development of immunotherapy for other types of cancers...
- A novel human papillomavirus type 6 neutralizing domain comprising two discrete regions of the major capsid protein L1W L McClements
Department of Virus and Cell Biology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Virology 289:262-8. 2001..This suggests that clusters of diverged residues, surrounded by conserved L1 sequences, are presented on the surface of assembled particles and are responsible for eliciting critical humoral immune responses to the virus...
- Codon optimized expression of HPV 16 E6 renders target cells susceptible to E6-specific CTL recognitionRegina Samorski
Deutsches Krebsforschungszentrum, Heidelberg, Forschungsschwerpunkt Infektionen und Krebs, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
Immunol Lett 107:41-9. 2006..Both findings are of potential relevance for the design of tumor vaccines...
- Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeresE C Goodwin
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Cell Growth Differ 12:525-34. 2001..Cells carrying the hTERT gene and control cells displayed identical responses to E2 expression. Therefore, HeLa cell senescence induced by HPV repression is not triggered by short telomeres or low levels of telomerase activity...
- Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancerKatsuyuki Hamada
Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Shitsukawa, Toon, Ehime 791 0295, Japan
Gynecol Oncol 103:820-30. 2006..We are exploring the potential use of antisense HPV RNA transcripts for gene therapy for HPV-positive cervical cancers...
Research Grants136 found, 100 shown here
- Predoctoral Training Program in VirologyPeter Tattersall; Fiscal Year: 2007..abstract_text> ..
- Genomic instability induced by the HPV-16 E7 oncoproteinStefan Duensing; Fiscal Year: 2009....
- A Phase I/II Trial of a Therapeutic HPV VaccineCornelia Trimble; Fiscal Year: 2004....
- Dendritic Cell Immunotherapy for Cervical CancerAlessandro Santin; Fiscal Year: 2004..This study will determine whether E7 antigen-loaded autologous DC vaccination offers the potential of therapeutic benefit for patients with HPV16 or HPV18-associated cervical cancer. ..
- CYTOTOXIC T LYMPHOCYTE RESPONSE TO HPV 16Mayumi Nakagawa; Fiscal Year: 2002....
- THERAPEUTIC VACCINES FOR HPV DISEASESCornelia Trimble; Fiscal Year: 2005..These facilities will be used to develop Dr. Trimble's ability to design and execute clinical trials evaluating preneoplastic HPV-associated lesions of the female lower genital tract. ..
- Mechanisms of mucosal immune evasion in high grade cervical dysplasiaCornelia L Trimble; Fiscal Year: 2010....
- Transcripitonal and Genetic Profiles in HNSCCsElaine Smith; Fiscal Year: 2007..abstract_text> ..
- Understanding and Enhancing T-Cell Responses to high Risk Human PapillomavirusesMayumi Nakagawa; Fiscal Year: 2010..In addition, this project has the potential for developing a novel adjuvant capable of enhancing peptide vaccine immunogenicity, which can be applied to other cancers as well as other infectious agents. ..
- International Collaborative HNC ResearchElaine Smith; Fiscal Year: 2007..This aim is to determine whether there is an easily administered, sensitive biomarker that can predict HPV-HR status in HNC tumors prior to therapy.. ..
- GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCERElaine Smith; Fiscal Year: 2003..abstract_text> ..
- Therapeutic DNA-MVA prime boost vaccination for HPV diseaseCornelia Trimble; Fiscal Year: 2007..We have a demonstrated record in clinical trial design and execution in this patient population, which is disproportionately comprised of minority women who do not access the medical care system effectively. ..
- ANALYSIS OF THE PDGF RECEPTOR JUXTAMEMBRANE DOMAINDaniel DiMaio; Fiscal Year: 2004..These experiments should provide new insights into the function and regulation of receptor tyrosine kinases and into human tumorigenesis, and they should elucidate the binding properties of a new family of WW domains. ..
- CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUSDaniel DiMaio; Fiscal Year: 2009..abstract_text> ..
- Role of HPV16 E7/E2F6 interaction in viral oncogenesisMargaret McLaughlin Drubin; Fiscal Year: 2006..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. ..
- A tri-antigen nasal anthrax vaccine against toxins and vegetative bacilli Zhengrong Cui; Fiscal Year: 2007..The same vaccine or its modified version can also be used in agricultural industries to vaccinate cattle. ..
- Activation of NF-kB by Human PapillomavirusesCRAIG WOODWORTH; Fiscal Year: 2006..Therefore, our results will provide basic information on how HPV might alter host response to infection. ..
- VSV-based Therapeutic Papilloma VaccineJanet Brandsma; Fiscal Year: 2007..The data provided by this investigation are likely to aid in the development a highly effective HPV vaccine to protect women against cervical cancer. ..
- PAPILLOMAVIRUS HOST INTERACTIONNeil Christensen; Fiscal Year: 2007..abstract_text> ..
- CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUSDaniel DiMaio; Fiscal Year: 2010..In addition, on the basis of these studies, we will continue to develop a novel protein engineering method to control biological processes, including infection by human immunodeficiency virus, an important co-factor in many cancers. ..
- PAPILLOMAVIRUS HOST INTERACTIONNeil Christensen; Fiscal Year: 2002..Defining the major protective viral epitopes on PV virions and on the early viral proteins in papillomavirus-infected cells will be key to planning effective immunotherapeutic management of this infectious disease. ..
- ANALYSIS OF CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUSDaniel DiMaio; Fiscal Year: 1991..Because of the association of papillomavirus with human carcinomas, our findings may be relevant to understanding the genesis of human cancers...
- Development of furanones for treatment of anthraxMartin Blaser; Fiscal Year: 2005..In initial studies, spores will be given subcutaneosly. Efficacy parameters will be defined as above. Successful trials can lead to phase I studies in humans, and treatment studies in non-human primates. ..
- Mathematical models of H. pylori gastric colonizationMartin Blaser; Fiscal Year: 2007..The experimental results will enable development of deterministic models relating genotypic and phenotypic variation with selection. ..
- Cell surface events of human papillomavirus type 16 and 18 infectionMartin Sapp; Fiscal Year: 2010..This should allow identification of cellular targets for drug therapies to prevent HPV induced cancers. ..
- Mathematical models of H. pylori gastric colonizationMartin J Blaser; Fiscal Year: 2010..Including mathematical analyses in these studies also permits a generalization of the principles and their applications to other microbes involved in human health and disease. ..
- Disappearing gastrointestinal microbiota in epidemic obesity.Martin J Blaser; Fiscal Year: 2010..We will focus on both maternal and antibiotic effects on the composition of the gastric and colonic bacterial populations, and their metabolic effects. ..
- Mechanisms of the Adenovirus E4-ORF1 OncoproteinRonald T Javier; Fiscal Year: 2011....
- H PYLORI RECOMBINATION AND GASTRIC COLONIZATIONMartin Blaser; Fiscal Year: 2001..pylori infections. ..
- CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCEMartin Blaser; Fiscal Year: 2002..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
- CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCEMartin Blaser; Fiscal Year: 2004..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
- li Suppression-enhanced HIV DNA VaccineMinzhen Xu; Fiscal Year: 2003..In a Phase II program Ii-RGC/gp120 DNA vaccines will be tested in non-human primates for the induction of a protective immune response against pathogenic HIV infection. ..
- Mechanisms of the Adenovirus E4-ORF1 OncoproteinRonald T Javier; Fiscal Year: 2010....
- Mathematical models of H. pylori gastric colonizationMartin Blaser; Fiscal Year: 2009..Including mathematical analyses in these studies also permits a generalization of the principles and their applications to other microbes involved in human health and disease. ..
- Diindolylmethane enhances the efficacy of preventive vaccines in an HPV transgeniDANIEL WAYNE SEPKOVIC; Fiscal Year: 2010..These women are at increased risk for cervical cancer. Our goal is to adapt preventive and therapeutic vaccines so that they can be used in this at risk population. ..
- HIV li-Key/Peptide VaccineMinzhen Xu; Fiscal Year: 2002..This entirely synthetic vaccine can be manufactured in a large scale and be given to those at high risk of HIV infection. ..
- MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATIONMartin Blaser; Fiscal Year: 2003..3) To examine the effect of recombination between two different H.pylori strains during experimental infections, and to develop representative mathematical models for this more complex phenomenon. ..
- CONTROL OF PAPILLOMAVIRUS EXPRESSION AND TRANSFORMATIONElliot Androphy; Fiscal Year: 2009..Understanding how E2 operates will provide insights into the biology of these pathways and infer how aberrations may occur that lead to the development of cancer. ..
- Small Molecule Inhibitors of Oncogenic Human PapillomavirusElliot Androphy; Fiscal Year: 2009..E6 is necessary for viral replication and for oncogenic progression. These compounds can be advanced to treat cervical, anogenital and head and neck cancers and their precursor lesions. ..
- ENHANCING HPV-16 E6-SPECIFIC ANTITUMOR IMMUNITYT C Wu; Fiscal Year: 2009..abstract_text> ..