- The multifunctional NS1 protein of influenza A viruses
Benjamin G Hale
Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
J Gen Virol 89:2359-76. 2008
- Epstein-Barr virus: 40 years on
Lawrence S Young
Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK
Nat Rev Cancer 4:757-68. 2004
..Despite such ubiquity, the link between EBV and 'endemic' Burkitt's lymphoma proved consistent and became the first of an unexpectedly wide range of associations discovered between this virus and tumours...
- Replication of hepatitis C virus
Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH 1011 Lausanne, Switzerland
Nat Rev Microbiol 5:453-63. 2007
..These efforts have already translated into the identification of novel antiviral targets and the development of new therapeutic strategies, some of which are currently undergoing clinical evaluation...
- A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
Sagi D Shapira
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
Cell 139:1255-67. 2009
During the course of a viral infection, viral proteins interact with an array of host proteins and pathways. Here, we present a systematic strategy to elucidate the dynamic interactions between H1N1 influenza and its human host...
- Nipah virus: a recently emergent deadly paramyxovirus
K B Chua
Department of Medical Microbiology, University of Malaya Medical Center, 50603 Kuala Lumpur, Malaysia
Science 288:1432-5. 2000
..Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans...
- Herpesvirus assembly: an update
Thomas C Mettenleiter
Friedrich Loeffler Institut, 17493 Greifswald Insel Riems, Germany
Virus Res 143:222-34. 2009
..C., 2004. Budding events in herpesvirus morphogenesis. Virus Res. 106, 167-180]...
- The landscape of human proteins interacting with viruses and other pathogens
Matthew D Dyer
Genetics, Bioinformatics, and Computational Biology Program, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
PLoS Pathog 4:e32. 2008
..Supplementary data accompanying this paper is available at http://staff.vbi.vt.edu/dyermd/publications/dyer2008a.html...
- Interleukin-10 and the interleukin-10 receptor
K W Moore
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
Annu Rev Immunol 19:683-765. 2001
..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
- Viral latency and its regulation: lessons from the gamma-herpesviruses
Samuel H Speck
Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA
Cell Host Microbe 8:100-15. 2010
..Here, we review the molecular basis of latency, with special attention to the gamma-herpesviruses, in which the understanding of this process is most advanced...
- Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus
Center for Hepatitis Research, Institute for Human Infections and Immunity, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1019, USA
J Virol 81:629-38. 2007
..We conclude that interactions between NS2 and E1 and p7 as well as between NS2 and NS3 are essential for virus assembly and/or release and that each of these viral proteins plays an important role in this process.
- Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions
Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany
PLoS Pathog 3:e103. 2007
..Although much has been learned about the function of individual viral proteins, the role of the HCV p7 protein in virus replication is not known...
- Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
Christopher T Jones
Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
J Virol 81:8374-83. 2007
..The protease domain of NS2 was required for infectivity, whereas its catalytic active site was dispensable. We conclude that p7 and NS2 function at an early stage of virion morphogenesis, prior to the assembly of infectious virus...
- 5'-Triphosphate RNA is the ligand for RIG-I
Division of Clinical Pharmacology, Department of Internal Medicine, University of Munich, 80336 Munich, Germany
Science 314:994-7. 2006
- Viral evasion and subversion of pattern-recognition receptor signalling
Andrew G Bowie
School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Nat Rev Immunol 8:911-22. 2008
- Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
PLoS Pathog 5:e1000252. 2009
..Thus, our data show that PB2 amino acids 627 and 701 are determinants of mammalian inter-host transmission in diverse virus backgrounds...
- Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteins
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 0610, USA
J Virol 85:86-97. 2011
..p7 may play an accessory role by regulating NS2 membrane topology, which is important for NS2-mediated protein interactions and therefore NS2 function...
- A newly discovered human pneumovirus isolated from young children with respiratory tract disease
B G van den Hoogen
Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
Nat Med 7:719-24. 2001
..Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years...
- The structural basis for cap binding by influenza virus polymerase subunit PB2
Grenoble Outstation, European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France
Nat Struct Mol Biol 15:500-6. 2008
..These findings clarify the nature of the cap binding site in PB2 and will allow efficient structure-based design of new anti-influenza compounds inhibiting viral transcription...
- Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
Xiao Dong Li
Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Proc Natl Acad Sci U S A 102:17717-22. 2005
- The pathophysiology of mitochondrial cell death
Douglas R Green
Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
Science 305:626-9. 2004
..The general rules governing the pathophysiology of MOMP and controversial issues regarding its regulation are discussed...
- The interferon system and vaccinia virus evasion mechanisms
Department of Cellular and Molecular Biology, Centro Nacional de Biotecnologia, CSIC, Ciudad Universitaria Cantoblanco, Madrid, Spain
J Interferon Cytokine Res 29:581-98. 2009
..The molecular dissection of how VACV prevents the IFN response is providing important insights on our understanding of antiviral action and immune surveillance...
- Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly
Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany
PLoS Pathog 4:e1000035. 2008
..Since domain III of NS5A is one of the most variable regions in the HCV genome, the results suggest that viral isolates may differ in their level of virion production and thus in their level of fitness and pathogenesis...
- Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit
Grenoble Outstation, European Molecular Biology Laboratory, Grenoble, France
PLoS Pathog 4:e1000136. 2008
..Host specificity is determined by multiple sites in different viral proteins, and mutation of only a limited number of these sites can lead to inter-species transmission...
- Expression of baculovirus P35 prevents cell death in Drosophila
B A Hay
Howard Hughes Medical Institute, University of California Berkeley 94720 3200
Development 120:2121-9. 1994
..Identification of molecules that interact biochemically or genetically with P35 in Drosophila should provide important insights into how cell death is regulated...
- Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor
Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, INSERM U412, Institut Fédératif de Recherche 128, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
J Biol Chem 278:41624-30. 2003
..Finally, by correlating expression of HCV receptors and infectivity, we suggest that, besides CD81 and SR-B1, additional hepatocyte-specific co-factor(s) are necessary for HCV entry...
- Hierarchical action and inhibition of plant Dicer-like proteins in antiviral defense
Institut de Biologie Moleculaire des Plantes, CNRS Unité Propre de Recherche UPR 2357, 12, rue du Général Zimmer, 67084 Strasbourg Cedex, France
Science 313:68-71. 2006
..These findings define a molecular framework for studying antiviral silencing and defense in plants...
- The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
Unit of Virus Host Cell Interactions, UJF EMBL CNRS, UMR 5233, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France
Nature 458:914-8. 2009
..These results will facilitate the optimisation of endonuclease inhibitors as potential new anti-influenza drugs...
- Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
Institute for Medical Microbiology, University of Basel, CH-4003 Basel, Switzerland
J Virol 76:5974-84. 2002
..Virchows Arch. B., 33:233-243, 1980). In view of this finding and the observation that all HCV proteins accumulate on the membranous web, we propose that the membranous web forms the viral replication complex in HCV-infected cells...
- Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus
Institute of Virology, Philipps University Marburg, Germany
PLoS Pathog 4:e11. 2008
..These findings demonstrate that adaptation of the viral polymerase to the nuclear import machinery plays an important role in interspecies transmission of influenza virus...
- Plant viral movement proteins: agents for cell-to-cell trafficking of viral genomes
William J Lucas
Section of Plant Biology, College of Biological Sciences, University of California, One Shields Ave, Davis, CA 95616, USA
Virology 344:169-84. 2006
- The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages
Targanta Therapeutics, 7170 Frederick Banting, Second Floor, Ville Saint Laurent, QC, Canada H4S 2A1
Proc Natl Acad Sci U S A 102:5174-9. 2005
..These phage genomes offer an exciting opportunity to discern molecular mechanisms of phage evolution and diversity...
- Genetic content of wild-type human cytomegalovirus
MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
J Gen Virol 85:1301-12. 2004
..The case in support of a lack of protein-coding potential in the region between UL105 and UL111A was also strengthened...
- A Begomovirus DNAbeta-encoded protein binds DNA, functions as a suppressor of RNA silencing, and targets the cell nucleus
Institute of Biotechnology, Zhejiang University, Hangzhou 310029, People's Republic of China
J Virol 79:10764-75. 2005
- Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses
Craig R Johnson
Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
J Gen Virol 92:1107-16. 2011
..Its discovery also provides a new potential target for immunological and pharmacological intervention in PRRS...
- Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
PLoS Pathog 5:e1000709. 2009
..These amino acids changes in PB2 and HA could serve as important molecular markers for assessing the pandemic potential of H5N1 field isolates...
- Nuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNA
G Renuka Kumar
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 3102, USA
Mol Cell Biol 30:4996-5008. 2010
- Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production
Ann L Wozniak
Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
PLoS Pathog 6:e1001087. 2010
..This loss of acidification is required for productive HCV infection, possibly through protecting nascent virus particles during an as yet uncharacterized maturation process...
- Patterns of HIV-1 protein interaction identify perturbed host-cellular subsystems
Jamie I Macpherson
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
PLoS Comput Biol 6:e1000863. 2010
..Thus, our work disentangles the complex set of HIV-1-host protein interactions in the HHPID, reconciles these with siRNA screens and provides an accessible and interpretable map of infection...
- Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase
Department of Virology, Division of Infectious Diseases, Imperial College London, Wright Fleming Institute, Norfolk Place, W2 1PG London, UK
J Virol 84:9978-86. 2010
..These four viral proteins constitute the minimal set for transcription and replication of influenza viral RNA...
- Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
Julie L McAuley
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Cell Host Microbe 2:240-9. 2007
..These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic...
- EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3
The Viral Oncology Program, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Cancer Res 68:1436-42. 2008
..Targeted suppression of CXCL-11/I-TAC by a viral-encoded miRNA may serve as an immunomodulatory mechanism in these tumors...
- Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation
Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, USA
PLoS Pathog 5:e1000403. 2009
..systems that recapitulate the entire life cycle of hepatitis C virus (HCV) indicate that several nonstructural viral proteins, including NS2, NS3, and NS5A, are involved in the process of viral assembly and release...
- A system for functional analysis of Ebola virus glycoprotein
Department of Virology and Molecular Biology, St Jude Children s Research Hospital, 332 North Lauderdale, P O Box 318, Memphis, TN 38101, USA
Proc Natl Acad Sci U S A 94:14764-9. 1997
..Thus, our VSV system should be useful for investigating the functions of glycoproteins from highly pathogenic viruses or those incapable of being cultured in vitro...
- Multiple amino acid substitutions are involved in the adaptation of H9N2 avian influenza virus to mice
Institute of Animal Husbandry and Veterinary Science, Hubei Academy of Agricultural Sciences, Wuhan 430064, Hubei, China
Vet Microbiol 138:85-91. 2009
..We conclude that multiple amino acid substitutions are likely to be involved in the adaptation of H9N2 avian influenza virus to mice...
- Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein
Department of Microbiology, The University of Hong Kong, Pokfulam, People s Republic of China
J Virol 83:7850-61. 2009
..These results suggest that NF90 inhibits influenza virus replication during the early phase of infection through direct interaction with viral NP...
- Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome
Susan M Varnum
Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201, USA
J Virol 78:10960-6. 2004
..proteins from purified HCMV virion preparations has indicated that the particle contains significantly more viral proteins than previously known...
- Viral control of mitochondrial apoptosis
INSERM, U848, Villejuif, France
PLoS Pathog 4:e1000018. 2008
..Here, we summarize the current knowledge on the viral modulation of mitochondrial apoptosis, by focusing in particular on the mechanisms by which viral proteins control the host cell death apparatus.
- Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation
Viral Immune Evasion Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
EMBO J 27:2147-57. 2008
..Therefore, this study shows for the first time the involvement of a DEAD box helicase in TBK1/IKKepsilon-mediated IRF activation and Ifnb promoter induction...
- The DNA beta satellite component associated with ageratum yellow vein disease encodes an essential pathogenicity protein (betaC1)
Department of Disease and Stress Biology, John Innes Centre, Colney, Norwich NR4 7UH, UK
Virology 324:37-47. 2004
..Our results demonstrate that the satellite encodes at least one protein that plays a major role in symptom development and is essential for disease progression in ageratum, the natural host of the AYVD complex...
- A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA
Helen M Wise
Department of Pathology, University of Cambridge, United Kingdom
J Virol 83:8021-31. 2009
..Thus, the influenza A virus proteome includes a 12th primary translation product that (similarly to PB1-F2) is nonessential for virus viability but whose loss, in particular genetic backgrounds, is detrimental to virus replication...
- The structure of a biologically active influenza virus ribonucleoprotein complex
Centro Nacional de Biotecnologia, Campus de Cantoblanco, Madrid, Spain
PLoS Pathog 5:e1000491. 2009
..The structure reported here will serve as a framework to generate a quasi-atomic model of the molecular machine responsible for viral RNA synthesis and to test new models for virus RNA replication and transcription...
- Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes
Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536, USA
J Virol 83:8379-95. 2009
..These data reveal a complex network of interactions involving NS2 and other viral structural and nonstructural proteins during virus assembly...
- Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission
Department of Virology, Erasmus Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, Netherlands
J Virol 84:3752-8. 2010
- Phages will out: strategies of host cell lysis
Dept of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843 2128, USA
Trends Microbiol 8:120-8. 2000
..By contrast, lytic single-stranded RNA and DNA phages accomplish lysis by producing a single lysis protein without muralytic activity...
- Virus glycosylation: role in virulence and immune interactions
David J Vigerust
Department of Pediatrics, Program in Vaccine Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Trends Microbiol 15:211-8. 2007
..This review focuses on recent findings on the importance of glycosylation to viral virulence and immune evasion for several prominent human pathogens...
- Structural biology of hepatitis C virus
Institut de Biologie et Chimie des Proteines, Lyon, France
Hepatology 39:5-19. 2004
..This article reviews the current knowledge of HCV structural biology...
- In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Department of Microbiology, Kanazawa Medical University, Ishikawa 920 0293, Japan
Retrovirology 6:19. 2009
..However, there have been no reports on the role of HBZ in patients with HTLV-1 associated inflammatory diseases...
- The autophagy machinery is required to initiate hepatitis C virus replication
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:14046-51. 2009
- Virus-encoded proteinases and proteolytic processing in the Nidovirales
Institute of Virology and Immunology, , Versbacher Str. 7, , Germany
J Gen Virol 81:853-79. 2000
- Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication
Tsai Ling Liao
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
EMBO J 29:3879-90. 2010
..Finally, we identified K184 as the ubiquitination site on NP and this residue is crucial for virus RNA replication. We propose that ubiquitination/deubiquitination of NP can be manipulated for antiviral therapeutic purposes...
- Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
PLoS Pathog 3:1374-9. 2007
- Selection of H5N1 influenza virus PB2 during replication in humans
Quynh Mai Le
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
J Virol 83:5278-81. 2009
..For efficient transmission, amino acid changes in viral proteins may be required. Here, we examined the amino acids at positions 627 and 701 of the PB2 protein...
- Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection
Medical Research Council Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
J Virol 82:12543-54. 2008
- A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history
Jose M Gonzalez
Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia CSIC, Darwin 3, 28049 Madrid, Spain
Virol J 7:59. 2010
..N1 also maintains an anti-apoptotic effect by acting similarly to cellular Bcl-2 proteins. Whether there are related families that could have similar functions is the main subject of this investigation...
- mRNA deep sequencing reveals 75 new genes and a complex transcriptional landscape in Mimivirus
Structural and Genomic Information Laboratory, Centre National de la Recherche Scientifique, UPR2589, Mediterranean Institute of Microbiology IFR88, Aix Marseille University, Parc Scientifique de Luminy, FR 13288 Marseille, France
Genome Res 20:664-74. 2010
- A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo
Gina M Conenello
Mount Sinai School of Medicine, Department of Microbiology, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
J Virol 85:652-62. 2011
..These data suggest that PB1-F2 N66S may contribute to the delay of innate immune responses, allowing for unchecked viral growth and ultimately severe immunopathology observed in the lungs...
- Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation
Center for Retrovirus Research, Department of Veterinary Biosciences and Molecular Virology Immunology, The Ohio State University, Columbus, OH 43210, USA
Blood 112:3788-97. 2008
..Our data indicate that Hbz expression enhances the proliferative capacity of HTLV-1-infected T cells, playing a critical role in cell survival and ultimately HTLV-1 tumorigenesis in the infected host...
- The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome
Andrew J Davison
MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
J Gen Virol 84:17-28. 2003
..We presently recognize 165 genes in CCMV and 145 in AD169; this compares with an estimate of 189 unique genes for AD169 made in 1990. Our best estimate for the complement of wild-type HCMV is 164 to 167 genes...
- Structures of influenza A proteins and insights into antiviral drug targets
Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA
Nat Struct Mol Biol 17:530-8. 2010
..of influenza A virus proteins (or fragments) help enhance our understanding of the molecular mechanisms of the viral proteins and the effects of drug resistance to improve drug design...
- PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology
Julie L McAuley
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
PLoS Pathog 6:e1001014. 2010
..These data suggest that the PB1-F2 protein contributes to the virulence of pandemic strains when the PB1 gene segment is recently derived from the avian reservoir...
- Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus
Sue Li Dahlroth
Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
FEBS J 276:6636-45. 2009
..Mutations specifically affecting host shutoff map to a surface region of the N-terminal domain, implying an essential role in protein-protein interactions, and link the RNase activity of the enzyme to mRNA degradation pathways...
- Backbone model of an aquareovirus virion by cryo-electron microscopy and bioinformatics
Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095 7364, USA
J Mol Biol 397:852-63. 2010
..Overall, this first backbone model of an aquareovirus virion provides a wealth of structural information for understanding the structural basis of GCRV assembly and transcription...
- Viral adaptation to host: a proteome-based analysis of codon usage and amino acid preferences
Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
Mol Syst Biol 5:311. 2009
..In groups of viruses that infect humans or other mammals, the highest observed level of adaptation of viral proteins to host codon usages is for those proteins that appear abundantly in the virion...
- Aberrant herpesvirus-induced polyadenylation correlates with cellular messenger RNA destruction
Yeon J Lee
Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, United States of America
PLoS Biol 7:e1000107. 2009
..SOX-induced mRNA turnover therefore represents both a novel mechanism of host shutoff as well as a new model system to probe the regulation of poly(A) tail-stimulated mRNA turnover in mammalian cells...
- Geminivirus pathogenicity protein C4 interacts with Arabidopsis thaliana shaggy-related protein kinase AtSKeta, a component of the brassinosteroid signalling pathway
Department of Disease and Stress Biology, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
Virology 362:428-40. 2007
..benthamiana identified additional amino acids within a central domain that contribute to the phenotype. The interaction with AtSKeta indicates that BCTV C4 interacts with the brassinosteroid signalling pathway...
- Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Nature 458:909-13. 2009
..The high conservation of this endonuclease active site among influenza strains indicates that PA(N) is an important target for the design of new anti-influenza therapeutics...
- Type 1 interferons and the virus-host relationship: a lesson in détente
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Science 312:879-82. 2006
..The plasticity that exists in these interactions provides us with a lesson in détente...
- Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome
Center for Retrovirus Research, Department of Veterinary Biosciences, Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH, USA
Retrovirology 6:8. 2009
..In a broad perspective, each new insight offers a prospective target for antiviral therapy and strategic improvement of gene transfer vectors...
- Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA
Science 293:1840-2. 2001
..Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection...
- A bridge crosses the active-site canyon of the Epstein-Barr virus nuclease with DNase and RNase activities
UMI UJF EMBL CNRS, Grenoble, France
J Mol Biol 391:717-28. 2009
..As the DNA strand that is subject to cleavage is likely to make a sharp turn in front of the bridge, endonuclease activity on single-stranded DNA stretches appears to be possible, explaining the cleavage of circular substrates...
- Evolutionarily conserved herpesviral protein interaction networks
Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munchen, Germany
PLoS Pathog 5:e1000570. 2009
..By combining interactomes of different species we were able to systematically address the low coverage of the Y2H system and to extract biologically relevant interactions which were not evident from single species...
- Suppression of RNA silencing by a geminivirus nuclear protein, AC2, correlates with transactivation of host genes
Institute of Botany, University of Basel, , CH-4056 Basel, Switzerland
J Virol 79:2517-27. 2005
- Emergence of H274Y oseltamivir-resistant A(H1N1) influenza viruses in Japan during the 2008-2009 season
Division of Public Health, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuoku, Niigata City, Niigata Prefecture 951 8510, Japan
J Clin Virol 47:23-8. 2010
..A substantial increase in oseltamivir-resistant A(H1N1) influenza viruses was reported in Europe in late 2007...
- Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis
Department of Pediatrics, The University of Texas Health Science Center at San Antonio, 78229, USA
J Virol 76:6185-96. 2002
..The feasibility of the system was illustrated through the generation of a KSHV mutant with the vIRF gene deleted. This cellular model is useful for the investigation of KSHV infection and pathogenesis...
- Influenza A virus protein PB1-F2 exacerbates IFN-beta expression of human respiratory epithelial cells
Ronan Le Goffic
Unite de Virologie et Immunologie Moleculaires, Unité de Recherche 892 Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy en Josas, France
J Immunol 185:4812-23. 2010
- Adenosine kinase inhibition and suppression of RNA silencing by geminivirus AL2 and L2 proteins
Biotechnology Center, Ohio State University, 201 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
J Virol 79:7410-8. 2005
..We previously found that these viral proteins interact with and inactivate adenosine kinase (ADK), a cellular enzyme important for adenosine salvage and ..
- An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link
Gemma L Kelly
Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, United Kingdom
PLoS Pathog 5:e1000341. 2009
- SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
J Cell Biol 175:261-70. 2006
..These results allow us to place SEL1L in the broader context of glycoprotein degradation, and imply the existence of multiple independent modes of extraction of misfolded substrates from the mammalian ER...
- Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air
Neal Van Hoeven
Influenza Division, Mailstop G 16, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 106:3366-71. 2009
..These findings demonstrate that the adaptation of the HA and PB2 proteins are critical for the development of pandemic influenza strains from avian influenza viruses...
- Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
The Walter and Eliza Hall Institute of Medical Research, 1G Poyal Parade, Parkville, Victoria 3050, Australia
Cell Death Differ 15:1564-71. 2008
- A two-year survey of the oseltamivir-resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir
Course of Clinical Nursing, Yamagata University Faculty of Medicine, Yamagata 990 9585, Japan
Virol J 7:53. 2010
- Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways
Brooke B Sahin
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
PLoS Pathog 6:e1000799. 2010
..We propose that KSHV ORF57 protein functions to enhance the nuclear stability of intronless viral transcripts by protecting them from a cellular RNA quality control pathway...
- Identification of functional domains in reovirus replication proteins muNS and mu2
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Virol 83:2892-906. 2009
- Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits
Department of Infection Biology, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
J Virol 81:1339-49. 2007
- The role of the Cucumber mosaic virus 2b protein in viral movement and symptom induction
Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, UK
Mol Plant Microbe Interact 22:642-54. 2009
..Taken together, the results indicate that the 2b protein itself is an important symptom determinant in certain hosts. However, they also suggest that the protein may somehow synergize symptom induction by other CMV-encoded factors...
- Functional analysis of proteins involved in movement of the monopartite begomovirus, Tomato yellow leaf curl virus
M R Rojas
Department of Plant Pathology, University of California, Davis, California 95616, USA
Virology 291:110-25. 2001
..Thus, the V1 and/or C4 may be analogs of the bipartite begomovirus BC1 that have evolved to mediate TYLCV movement within phloem tissue...
- Recombinant respiratory syncytial virus with the G and F genes shifted to the promoter-proximal positions
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-8007, USA
J Virol 76:11931-42. 2002
- The complete nucleotide sequence of phi CTX, a cytotoxin-converting phage of Pseudomonas aeruginosa: implications for phage evolution and horizontal gene transfer via bacteriophages
Department of Bacteriology, Shinshu University School of Medicine, Matsumoto, Japan
Mol Microbiol 31:399-419. 1999
..They appear to be deeply concerned in the acquisition of various genes that are horizontally transferred by bacteriophage infection...
- The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infection
P S Beisser
Department of Medical Microbiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
J Virol 72:2352-63. 1998
..We conclude that the RCMV R33 gene plays a vital role in the pathogenesis of infection...
- The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions
Fan Xiu Zhu
Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
J Virol 77:4221-30. 2003
- Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication
Robert D Allen
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Virology 365:250-9. 2007