repressor proteins

Summary

Summary: Proteins which are normally bound to the operator locus of an operon, thereby preventing transcription of the structural genes. In enzyme induction, the substrate of the inducible enzyme binds to the repressor protein, causing its release from the operator and freeing the structural genes for transcription. In enzyme repression, the end product of the enzyme sequence binds to the free repressor protein, the resulting complex then binds to the operator and prevents transcription of the structural genes.

Top Publications

  1. ncbi TIF1gamma, a novel member of the transcriptional intermediary factor 1 family
    L Venturini
    Centre National de la Recherche Scientifique, Unité Propre de Recherche 9051, Laboratoire Associé au Comité de Paris de la Ligue contre le Cancer, Hopital St Louis, France
    Oncogene 18:1209-17. 1999
  2. ncbi CTCF: master weaver of the genome
    Jennifer E Phillips
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Cell 137:1194-211. 2009
  3. ncbi Genome-wide mapping of in vivo protein-DNA interactions
    David S Johnson
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
    Science 316:1497-502. 2007
  4. ncbi Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    John L Rinn
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:1311-23. 2007
  5. ncbi Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    Ahmad M Khalil
    The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:11667-72. 2009
  6. ncbi Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    R E Amir
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 23:185-8. 1999
  7. ncbi Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
    Manching Ku
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA
    PLoS Genet 4:e1000242. 2008
  8. ncbi Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2
    Aditi Kanhere
    Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Mol Cell 38:675-88. 2010
  9. ncbi Role of the polycomb protein EED in the propagation of repressive histone marks
    Raphael Margueron
    Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, New York 10016, USA
    Nature 461:762-7. 2009
  10. ncbi A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
    Xin Zeng
    Neurobiology Program, Children's Hospital Boston, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 438:873-7. 2005

Research Grants

  1. Targeting DNA Secondary Structures for Bcl-2 Gene Regulation
    Danzhou Yang; Fiscal Year: 2010
  2. DRUG SENSITIVITY OF CALCIUM MODULATORS FROM BRAIN TUMORS
    William Hait; Fiscal Year: 2000
  3. Mediator and epigenetic control of neuronal gene expression and differentiation
    Thomas Boyer; Fiscal Year: 2009
  4. Mediator and epigenetic control of neuronal gene expression and differentiation
    Thomas G Boyer; Fiscal Year: 2010
  5. REGULATION OF DEFENSE SIGNALING IN TOMATO
    Gregg Howe; Fiscal Year: 2009
  6. REGULATION OF DEFENSE SIGNALING IN TOMATO
    Gregg A Howe; Fiscal Year: 2010
  7. REGULATION OF DEFENSE SIGNALING IN TOMATO
    Gregg A Howe; Fiscal Year: 2010
  8. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola C Partridge; Fiscal Year: 2010
  9. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2009
  10. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2007

Detail Information

Publications189 found, 100 shown here

  1. ncbi TIF1gamma, a novel member of the transcriptional intermediary factor 1 family
    L Venturini
    Centre National de la Recherche Scientifique, Unité Propre de Recherche 9051, Laboratoire Associé au Comité de Paris de la Ligue contre le Cancer, Hopital St Louis, France
    Oncogene 18:1209-17. 1999
    ..Since deletion of a novel motif unique to the three TIF1 proteins, called TIF1 signature sequence (TSS), abrogates transcriptional repression by TIF1gamma, this motif likely participates in TIF1 dependent repression...
  2. ncbi CTCF: master weaver of the genome
    Jennifer E Phillips
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Cell 137:1194-211. 2009
    ....
  3. ncbi Genome-wide mapping of in vivo protein-DNA interactions
    David S Johnson
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
    Science 316:1497-502. 2007
    ..96] and statistical confidence (P <10(-4)), properties that were important for inferring new candidate interactions. These include key transcription factors in the gene network that regulates pancreatic islet cell development...
  4. ncbi Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    John L Rinn
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:1311-23. 2007
    ..Thus, transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance; these results have broad implications for gene regulation in development and disease states...
  5. ncbi Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    Ahmad M Khalil
    The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:11667-72. 2009
    ..We propose a model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression...
  6. ncbi Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    R E Amir
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 23:185-8. 1999
    ..This suggests that the mother is a germline mosaic for this mutation. Our study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT...
  7. ncbi Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
    Manching Ku
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA
    PLoS Genet 4:e1000242. 2008
    ..We propose that large CpG islands depleted of activating motifs confer epigenetic memory by recruiting the full repertoire of Polycomb complexes in pluripotent cells...
  8. ncbi Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2
    Aditi Kanhere
    Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Mol Cell 38:675-88. 2010
    ..We propose that short RNAs play a role in the association of PRC2 with its target genes...
  9. ncbi Role of the polycomb protein EED in the propagation of repressive histone marks
    Raphael Margueron
    Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, New York 10016, USA
    Nature 461:762-7. 2009
    ..These findings suggest a model for the propagation of the H3K27me3 mark that accounts for the maintenance of repressive chromatin domains and for the transmission of a histone modification from mother to daughter cells...
  10. ncbi A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
    Xin Zeng
    Neurobiology Program, Children's Hospital Boston, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 438:873-7. 2005
    ....
  11. ncbi Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes
    Jose Silva
    X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Dev Cell 4:481-95. 2003
    ..Functional analysis demonstrates that Eed-Enx1 is required to establish methylation of histone H3 at lysine 9 and/or lysine 27 on Xi and that this, in turn, is required to stabilize the Xi chromatin structure...
  12. ncbi Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
    Jing Zhao
    Howard Hughes Medical Institute, Boston, MA 02115, USA
    Science 322:750-6. 2008
    ..Likewise, PRC2 deficiency compromises Xist up-regulation. Therefore, RepA, together with PRC2, is required for the initiation and spread of XCI. We conclude that a ncRNA cofactor recruits Polycomb complexes to their target locus...
  13. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  14. ncbi The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
    C Sidrauski
    Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco 94143 0448, USA
    Cell 90:1031-9. 1997
    ..The addition of purified tRNA ligase completes splicing; we therefore have reconstituted HAC1 mRNA splicing in vitro from purified components...
  15. ncbi Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice
    Jongdae Shin
    Program in Gene Function and Expression, University of Massachusetts Medical School UMMS, Worcester, Massachusetts 01605, USA
    Nature 467:977-81. 2010
    ..These results assign crucial functions to the maternal deposit of Rnf12/RLIM for the initiation of imprinted XCI...
  16. ncbi The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 22:894-907. 2008
    ..Conversely, inhibition of miR-200 reduced E-cadherin expression, increased expression of Vimentin, and induced EMT. Our data identify miR-200 as a powerful marker and determining factor of the epithelial phenotype of cancer cells...
  17. ncbi CTCF physically links cohesin to chromatin
    Eric D Rubio
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle WA 98195, USA
    Proc Natl Acad Sci U S A 105:8309-14. 2008
    ..These results have implications for the functional role of cohesin subunits in the pathogenesis of Cornelia de Lange syndrome and Roberts syndromes...
  18. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  19. ncbi KAP1 controls endogenous retroviruses in embryonic stem cells
    Helen M Rowe
    School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nature 463:237-40. 2010
    ..Correspondingly, IAP 5'UTR sequences can impose in cis KAP1-dependent repression on a heterologous promoter in ES cells. Our results establish that KAP1 controls endogenous retroelements during early embryonic development...
  20. ncbi Stochastic gene expression in a single cell
    Michael B Elowitz
    Laboratory of Cancer Biology, Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10021, USA
    Science 297:1183-6. 2002
    ..These results establish a quantitative foundation for modeling noise in genetic networks and reveal how low intracellular copy numbers of molecules can fundamentally limit the precision of gene regulation...
  21. ncbi Functional specialization within the Fur family of metalloregulators
    Jin Won Lee
    Department of Microbiology, Cornell University, Wing Hall, Ithaca, NY 14853 8101, USA
    Biometals 20:485-99. 2007
    ..Despite numerous studies, the mechanism of metal ion sensing by Fur family proteins is still controversial. Other family members use metal catalyzed oxidation reactions to sense peroxide-stress (PerR) or the availability of heme (Irr)...
  22. ncbi Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
    Ragnhild Eskeland
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Mol Cell 38:452-64. 2010
    ..We suggest that Ring1B-mediated chromatin compaction acts to directly limit transcription in vivo...
  23. ncbi Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter
    L M Guzman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 177:4121-30. 1995
    ..We have exploited the tight regulation of the PBAD promoter to study the phenotypes of null mutations of essential genes and explored the use of pBAD vectors as an expression system...
  24. ncbi FOXP2 as a molecular window into speech and language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Genet 25:166-77. 2009
    ..This body of research represents the first functional genetic forays into neural mechanisms contributing to human spoken language...
  25. ncbi Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
    Michel Warny
    Acambis Inc, Cambridge, MA, USA
    Lancet 366:1079-84. 2005
    ..We characterised the dominant strain of this epidemic to determine whether it produces higher amounts of toxins A and B than those produced by non-epidemic strains...
  26. ncbi Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding
    Nathan P Gomes
    Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 24:1022-34. 2010
    ..Therefore, CTCF plays a pivotal role in dampening the p53 apoptotic response by acting as a gene-specific repressor...
  27. ncbi Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
    Jamy C Peng
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 139:1290-302. 2009
    ..Our findings illuminate a mechanism of histone methylation regulation in pluripotent cells and during early cell-fate transitions...
  28. ncbi Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
    Raffaella Villa
    Centre de Regulacio Genomica, C Dr Aiguader 88, 08003 Barcelona, Spain
    Cancer Cell 11:513-25. 2007
    ..Our results demonstrate that the direct targeting of Polycomb group proteins by an oncogene plays a key role during carcinogenesis...
  29. ncbi Repression of FLOWERING LOCUS C and FLOWERING LOCUS T by the Arabidopsis Polycomb repressive complex 2 components
    Danhua Jiang
    Department of Biological Sciences, National University of Singapore, Singapore, Republic of Singapore
    PLoS ONE 3:e3404. 2008
    ..Given the central roles of FLC and FT in flowering-time regulation in Arabidopsis, these findings suggest that the CLF-containing PRC2-like complexes play a significant role in control of flowering in Arabidopsis...
  30. ncbi Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
    Fabio Mohn
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Mol Cell 30:755-66. 2008
    ..These data suggest a model how de novo DNA methylation and dynamic switches in Polycomb targets restrict pluripotency and define the developmental potential of progenitor cells...
  31. ncbi Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase
    Inmaculada Hernández-Muñoz
    Division of Molecular Genetics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:7635-40. 2005
    ..We further demonstrate that MACROH2A1 deposition is regulated by the CULLIN3/SPOP ligase complex and is actively involved in stable X inactivation, likely through the formation of an additional layer of epigenetic silencing...
  32. ncbi Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    Jakub Godlewski
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, Ohio 43210
    Cancer Res 68:9125-30. 2008
    ....
  33. ncbi The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    E Batlle
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain
    Nat Cell Biol 2:84-9. 2000
    ..Inhibition of Snail function in epithelial cancer cell lines lacking E-cadherin protein restores the expression of the E-cadherin gene...
  34. ncbi Bmi1 regulates mitochondrial function and the DNA damage response pathway
    Jie Liu
    Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 459:387-92. 2009
    ....
  35. ncbi Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs
    Henriette O'Geen
    Department of Pharmacology, University of California Davis, Davis, California, United States of America
    PLoS Genet 3:e89. 2007
    ..Because KAP1 is recruited to the DNA via interaction with KRAB-ZNF proteins, we suggest that expression of KRAB-ZNF genes may be controlled via an auto-regulatory mechanism involving KAP1...
  36. ncbi The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting
    Mary E Donohoe
    Howard Hughes Medical Institute, USA
    Nature 460:128-32. 2009
    ..Thus, we have identified the first trans-factor that regulates counting, and ascribed new functions to Oct4 during X-chromosome reprogramming...
  37. ncbi Histone deacetylases (HDACs): characterization of the classical HDAC family
    Annemieke J M de Ruijter
    Academic Medical Centre, University of Amsterdam, Amsterdam, The, Netherlands
    Biochem J 370:737-49. 2003
    ..This challenging field has generated many fascinating results which will ultimately lead to a better understanding of the mechanism of gene transcription as a whole...
  38. ncbi Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly
    I M Hanson
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Nat Genet 6:168-73. 1994
    ..We therefore propose that a variety of anterior segment anomalies may be associated with PAX6 mutations...
  39. ncbi TSC2 mediates cellular energy response to control cell growth and survival
    Ken Inoki
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 115:577-90. 2003
    ..These observations demonstrate a model where TSC2 functions as a key player in regulation of the common mTOR pathway of protein synthesis, cell growth, and viability in response to cellular energy levels...
  40. ncbi Polycomb group protein-mediated repression of transcription
    Lluis Morey
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Trends Biochem Sci 35:323-32. 2010
    ....
  41. ncbi Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
    Ji Won Jung
    Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
    Cell Mol Life Sci 67:1165-76. 2010
    ..These results suggest that HDAC activity might be important for MSC self-renewal by balancing PcGs and JMJD3 expression, which govern cellular senescence by p16(INK4A) regulation...
  42. ncbi Regulatory circuits in Helicobacter pylori : network motifs and regulators involved in metal-dependent responses
    Alberto Danielli
    Department of Biology, University of Bologna, Bologna, Italy
    FEMS Microbiol Rev 34:738-52. 2010
    ..These motifs appear to confer versatile dynamics of metal-dependent responses by extensive horizontal connections between the regulators and feedback control of metal-cofactor availability...
  43. ncbi The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    J Clin Invest 119:3626-36. 2009
    ..Our results provide functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer...
  44. ncbi KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading
    Anna C Groner
    School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    PLoS Genet 6:e1000869. 2010
    ..This finding not only suggests auto-regulatory mechanisms in the control of KRAB-ZFP gene clusters, but also provides important cues for interpreting future genome-wide DNA binding data of KRAB-ZFPs and KAP1...
  45. ncbi Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice
    Bernd Schuettengruber
    Institut de Genetique Humaine, CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Development 136:3531-42. 2009
    ..Finally, we focus on the dynamics of PcG protein complex action during cell fate transitions and on the implications of histone modifications for cell lineage commitment...
  46. ncbi A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation
    D Beckett
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore 21250, USA
    Protein Sci 8:921-9. 1999
    ..We conclude that the 14-mer peptide efficiently mimics the biotin acceptor function of the much larger protein domain normally recognized by BirA...
  47. ncbi Genome regulation by polycomb and trithorax proteins
    Bernd Schuettengruber
    Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Cell 128:735-45. 2007
    ..Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery...
  48. ncbi Crystal structure of the Vibrio cholerae ferric uptake regulator (Fur) reveals insights into metal co-ordination
    Md Arif Sheikh
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
    Mol Microbiol 72:1208-20. 2009
    ..An analysis of the metal binding properties shows that V. cholerae Fur can be activated by a range of divalent metals...
  49. ncbi MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases
    Jennifer M Doyle
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    Mol Cell 39:963-74. 2010
    ..For example, MAGE-C2-TRIM28 is shown to target p53 for degradation in a proteasome-dependent manner, consistent with its tumorigenic functions. These findings define a biochemical and cellular function for the MAGE protein family...
  50. ncbi Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice
    Yoshiyuki Seki
    Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology, RIKEN Kobe Institute, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
    Development 134:2627-38. 2007
    ..We suggest the possibility that active repression of an essential enzyme and subsequent unique cellular dynamics ensures successful implementation of genome-wide epigenetic reprogramming in migrating PGCs...
  51. ncbi Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila
    Julide Bilen
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Genet 3:1950-64. 2007
    ..These findings provide new insight into molecular pathways of polyQ toxicity, defining novel targets for promoting neuronal survival in human neurodegenerative disease...
  52. ncbi Cleavage of bacteriophage lambda cI repressor involves the RecA C-terminal domain
    Vitold E Galkin
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908 0733, USA
    J Mol Biol 385:779-87. 2009
    ..Under conditions where the repressor cleavage rates are the highest, cI is coordinated within the groove by contacts with RecA's CTD. These observations provide a framework for understanding previous genetic and biochemical observations...
  53. ncbi Bypassing a kinase activity with an ATP-competitive drug
    Feroz R Papa
    Department of Medicine, University of California, San Francisco, CA 94143 2200, USA
    Science 302:1533-7. 2003
    ..Thus, rather than through phosphorylation per se, a conformational change in the kinase domain triggered by occupancy of the active site with a ligand leads to activation of all known downstream functions...
  54. ncbi Pax 6: mastering eye morphogenesis and eye evolution
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Trends Genet 15:371-7. 1999
    ..It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution...
  55. ncbi Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
    R Z Chen
    The Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 27:327-31. 2001
    ..Mecp2 deficiency in these neurons is sufficient to cause neuronal dysfunction with symptomatic manifestation similar to Rett syndrome...
  56. ncbi The many roles of the transcriptional regulator CTCF
    Katherine L Dunn
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Biochem Cell Biol 81:161-7. 2003
    ..Recent studies have provided new insight into the mechanism through which this factor acts at various levels of gene regulation...
  57. ncbi Cellular defenses against superoxide and hydrogen peroxide
    James A Imlay
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Annu Rev Biochem 77:755-76. 2008
    ..Current research seeks to identify these, and bacteria comprise an exceptionally accessible experimental system that has provided many of the answers. This manuscript reviews recent developments and identifies remaining puzzles...
  58. ncbi Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    W Weichert
    Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
    Br J Cancer 98:604-10. 2008
    ..Also, the highly significant prognostic value of HDAC2 clearly deserves further study...
  59. ncbi Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
    Andreas Fischer
    Physiological Chemistry I, Biocenter, Theodor Boveri Institute, University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Nucleic Acids Res 35:4583-96. 2007
    ..In addition, we summarize recent progress on the identification of potential target genes and the analysis of mouse models...
  60. ncbi Bmi1 is expressed in vivo in intestinal stem cells
    Eugenio Sangiorgi
    Howard Hughes Medical Institute and Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Nat Genet 40:915-20. 2008
    ..Unexpectedly, the distribution of Bmi1-expressing stem cells along the length of the small intestine suggested that mammals use more than one molecularly distinguishable adult stem cell subpopulation to maintain organ homeostasis...
  61. ncbi decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
    T Xie
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Cell 94:251-60. 1998
    ..We constructed mutant germline stem cell clones to show that the dpp signal is directly received by germline stem cells. Thus, dpp signaling helps define a niche that controls germline stem cell proliferation...
  62. ncbi Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4
    D G Edmondson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 10:1247-59. 1996
    ..Tup1/histone interactions are negatively influenced by high levels of histone acetylation, suggesting a mechanism whereby the organization of chromatin may be modulated in response to changing environmental signals...
  63. ncbi Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary
    Michael Witcher
    Regulatory Biology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Mol Cell 34:271-84. 2009
    ....
  64. ncbi Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter
    Kimberly M Baker
    Department of Molecular Genetics and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 278:17876-84. 2003
    ..These results support a role for ets-2 as a repressor and indicate that components of the mammalian SNF/SWI complex are required as co-repressors...
  65. ncbi A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead
    Tomasz Wilanowski
    Rotary Bone Marrow Research Laboratory, Royal Melbourne Hospital Research Foundation, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria 3050, Australia
    Mech Dev 114:37-50. 2002
    ..This sequence and functional conservation indicates that the new mammalian members of this family play important developmental roles...
  66. ncbi hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer
    Patsie Polly
    Muscle Development Unit, Children s Medical Research Institute, Wentworthville, New South Wales 2145, Australia
    J Biol Chem 278:36603-10. 2003
    ..The data support the role of hMusTRD1alpha1 as a repressor of slow fiber-specific transcription through mechanisms involving direct interactions with MEF2C and the nuclear receptor co-repressor...
  67. ncbi Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split
    Gregory S Yochum
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Mol Cell Biol 22:7868-76. 2002
    ..In addition, Pf1 and MRG15 bind different domains on mSin3A. Together, these data suggest that the unique functions of MRG15 are elicited through the action of an MRG15/Pf1/mSin3A complex...
  68. ncbi Tomato heat stress transcription factor HsfB1 represents a novel type of general transcription coactivator with a histone-like motif interacting with the plant CREB binding protein ortholog HAC1
    Kapil Bharti
    Department of Molecular Cell Biology, Goethe University Frankfurt, D-60439 Frankfurt, Germany
    Plant Cell 16:1521-35. 2004
    ..Using small interfering RNA-mediated knock down of HAC1 expression in Arabidopsis thaliana mesophyll protoplasts, the crucial role for the coactivator function of HsfB1 was confirmed...
  69. ncbi Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
    Antonio A Postigo
    Division of Molecular Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 22:2453-62. 2003
    ..This model of regulation by ZEB proteins also functions in vivo, where they have opposing effects on the regulation of TGFbeta family-dependent genes during Xenopus development...
  70. ncbi ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules
    Danette L Daniels
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 10:573-84. 2002
    ..The C-terminal armadillo repeats of beta-catenin may be an attractive target for compounds designed to disrupt aberrant beta-catenin-mediated transcription associated with various cancers...
  71. ncbi Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner
    Dawn O'Reilly
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 278:21909-19. 2003
    ..We propose that expression of CD68 in myeloid cells requires the Ets transcription factors Elf-1 and PU.1 and CD68 expression is down-regulated in lymphoid cells by combinatorial interactions between PU.1 and IRF-4...
  72. ncbi D-mef2 is a target for Tinman activation during Drosophila heart development
    K Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    EMBO J 16:515-22. 1997
    ..These results define the only known in vivo target for transcriptional activation by Tinman and demonstrate that D-mef2 lies directly downstream of tinman in the genetic cascade controlling heart formation in Drosophila...
  73. ncbi GATA-6 regulates genes promoting synthetic functions in vascular smooth muscle cells
    John J Lepore
    Molecular Cardiology Research Center, Department of Medicine, University of Pennsylvania Health System, Philadelphia 19104, USA
    Arterioscler Thromb Vasc Biol 25:309-14. 2005
    ..The objective of this study was to identify bona fide target genes regulated by GATA-6 in VSMCs...
  74. ncbi TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1
    S I Hsu
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 20:2273-85. 2001
    ....
  75. ncbi Interplay of Pax6 and SOX2 in lens development as a paradigm of genetic switch mechanisms for cell differentiation
    Hisato Kondoh
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Dev Biol 48:819-27. 2004
    ..Thus, the regulation of SOX2 (and SOX1/3) and its partner factors, exemplified by Pax6, determines the spatio-temporal order of the occurrence of cell differentiation...
  76. ncbi FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1
    Wei Hong
    Division of Hematology, Children's Hospital of Philadelphia, PA 19104, USA
    EMBO J 24:2367-78. 2005
    ..Together, these studies show that FOG-1 and likely other FOG-like proteins are corepressors that link GATA factors to histone deacetylation and nucleosome remodeling...
  77. ncbi Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors
    Manching Ku
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Mol Cell Biol 25:7144-57. 2005
    ..These results suggest a model in which TFII-I family proteins have opposing effects in the regulation of the Gsc gene in response to a TGFbeta/activin signal...
  78. ncbi Stage-specific repression by the EKLF transcriptional activator
    Xiaoyong Chen
    Mount Sinai School of Medicine, Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Cell Biol 24:10416-24. 2004
    ..These data suggest a model whereby the stage of the erythroid cell alters the acetylation status of EKLF and plays a critical role in directing its coactivator-corepressor interactions and downstream transcriptional effects...
  79. ncbi A ternary complex of transcription factors, Nishéd and NFATc4, and co-activator p300 bound to an intronic sequence, intronic regulatory element, is pivotal for the up-regulation of myosin light chain-2v gene in cardiac hypertrophy
    Sumy Mathew
    Department of Anatomy and Cell Biology, Center for Cardiovascular and Muscle Research, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Biol Chem 279:41018-27. 2004
    ....
  80. ncbi TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1
    Naama Rave-Harel
    Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92903, USA
    J Biol Chem 279:30287-97. 2004
    ..Finally, Pbx1 is expressed in GnRH neurons in embryonic as well as mature mice, suggesting that the associations between TALE homeodomain proteins and Oct-1 regulate neuron-specific expression of the GnRH gene in vivo...
  81. ncbi The Optimedin gene is a downstream target of Pax6
    Oleg Grinchuk
    Section of Molecular Mechanisms of Glaucoma, Laboratory of Molecular and Developmental Biology, NEI, National Institutes of Health, Bethesda, Maryland 20892 0704, USA
    J Biol Chem 280:35228-37. 2005
    ..Pax6 regulation of Optimedin in the eye and brain may directly affect multiple developmental processes, including cell migration and axon growth...
  82. ncbi Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator
    Eric S Tien
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Science, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 279:24053-63. 2004
    ..The results described here suggest that CIT-ED2 is a coactivator of PPARalpha and that both proteins may participate in signaling cascades of hypoxic response and angiogenesis...
  83. ncbi Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression
    Zhigao Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nature 428:185-9. 2004
    ..We conclude that growth and developmental signals modulate smooth muscle gene expression by regulating the association of SRF with antagonistic cofactors...
  84. ncbi Characterization of the mouse lysosomal sialidase promoter
    Marc J Champigny
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Gene 319:177-87. 2003
    ..Taken together, these results identify cis- and trans-acting factors involved in the regulation of sialidase and point to mechanisms of gene upregulation...
  85. ncbi Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6
    Susan E Samaras
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 22:4702-13. 2002
    ..Collectively, these data suggest an important role for both HNF3 beta and Pax6 in regulating pdx-1 expression in beta cells...
  86. ncbi Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
    E Labbe
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Mol Cell 2:109-20. 1998
    ..Thus, we describe a mechanism whereby Smad2 and Smad3 positively and negatively regulate a TGF beta/activin target gene...
  87. ncbi Sry and Sox9: mammalian testis-determining genes
    P Koopman
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Cell Mol Life Sci 55:839-56. 1999
    ....
  88. ncbi Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis
    H Kuo
    UCSD Salk Program in Molecular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0613, USA
    Development 126:4223-34. 1999
    ..5 and GATA-4. We have shown that this cooperative regulation is dependent on binding of GATA-4 to its cognate DNA sequence in the promoter, which suggests that Nkx2.5 controls CARP expression, at least in part, through GATA-4...
  89. ncbi Expression of the beta3 tubulin gene (beta Tub60D) in the visceral mesoderm of Drosophila is dependent on a complex enhancer that binds Tinman and UBX
    T Kremser
    Fachbereich Biologie, Entwicklungsbiologie, Philipps Universitat Marburg, Germany
    Mol Gen Genet 262:643-58. 1999
    ..Thus the vm1 enhancer of the beta3 tubulin gene contains a complex array of elements that are involved in transactivation by a combination of tissue- and position-specific factors including Tinman and UBX...
  90. ncbi Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    B Wang
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 100:423-34. 2000
    ..The high relative abundance and potency of Gli3 repressor suggest specialization of Gli3 and its products for negative Hedgehog pathway regulation...
  91. ncbi Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif
    T Toki
    Department of Pediatrics, Hirosaki University, Japan
    Oncogene 14:1901-10. 1997
    ..The results suggest that the small Maf family proteins function in human cells through interaction with various basic-leucine zipper-type transcription factors...
  92. ncbi A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor
    M Fedele
    Centro di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano Università degli Studi di Napoli Federico II via S Pansini, 5, 80131 Napoli, Italy
    J Biol Chem 275:7894-901. 2000
    ..In addition, RNF4 was also found to associate with HMGI(Y), a chromatin-modeling factor containing AT-hook domains...
  93. ncbi Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter
    X Ma
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:10389-95. 1997
    ..This novel protein is designated GLp109 for its inducibility by IFN-gamma or lipopolysaccharide. Its possible role in the activation of the IL-12 p40 promoter is discussed...
  94. ncbi CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway
    Y Zou
    American Heart Association Bugher Foundation Center for Molecular Biology, Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    Development 124:793-804. 1997
    ....
  95. ncbi Expression and function of the homeodomain-containing protein Hex in thyroid cells
    L Pellizzari
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Italy
    Nucleic Acids Res 28:2503-11. 2000
    ..The DNA binding specificity of the Hex homeodomain, therefore, is more 'relaxed' than that observed in the majority of other homeo-domains...
  96. ncbi Cloning of interferon-stimulated gene 17: the promoter and nuclear proteins that regulate transcription
    D J Perry
    Department of Animal Science, University of Wyoming, Laramie 82071 3684, USA
    Mol Endocrinol 13:1197-206. 1999
    ..It is concluded that the bISG17 gene is similar to the hISG15 gene, retains an ISRE that interacts with IRF-1, and is possibly induced initially by the STATs and later by IRF-1 in response to IFN-tau during early pregnancy...
  97. ncbi Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor
    G Meroni
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
    EMBO J 16:2892-906. 1997
    ..3 in a region that frequently undergoes loss of heterozygosity in a number of malignancies, together with the biochemical and expression features, suggest involvement of ROX in human neoplasia...
  98. ncbi SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors
    C D Laherty
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Cell 2:33-42. 1998
    ....
  99. ncbi ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex
    J Wang
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda MD 20892, USA
    Proc Natl Acad Sci U S A 95:10860-5. 1998
    ..This observation provides a mechanism for how the AML1/ETO fusion may inhibit expression of AML1-responsive target genes and disturb normal hematopoiesis...
  100. ncbi Negative autoregulation of the organizer-specific homeobox gene goosecoid
    V Danilov
    Forschungszentrum Karlsruhe, Institute of Genetics, P O Box 3640, D 76021 Karlsruhe, Federal Republic of Germany
    J Biol Chem 273:627-35. 1998
    ..Our results suggest a role for goosecoid in restricting organizer activity in the vertebrate gastrula embryo...
  101. ncbi Fis, an accessorial factor for transcriptional activation of the mar (multiple antibiotic resistance) promoter of Escherichia coli in the presence of the activator MarA, SoxS, or Rob
    R G Martin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 0560, USA
    J Bacteriol 179:7410-9. 1997
    ..Thus, Fis acts as an accessory transcriptional activator at the mar promoter...

Research Grants75

  1. Targeting DNA Secondary Structures for Bcl-2 Gene Regulation
    Danzhou Yang; Fiscal Year: 2010
    ..a manner analogous to the genetic switch in the bacteriophage lambda controlled by the interactive Cro and Repressor proteins, whose operator regions (ORs) overlap with each other's promoter regions and thereby inhibit each other&..
  2. DRUG SENSITIVITY OF CALCIUM MODULATORS FROM BRAIN TUMORS
    William Hait; Fiscal Year: 2000
    ..The decreased protein synthesis, perhaps through degradation of short-lived repressor proteins, allows cell division to proceed in a variety of experimental systems...
  3. Mediator and epigenetic control of neuronal gene expression and differentiation
    Thomas Boyer; Fiscal Year: 2009
    ..In this capacity, Mediator serves to channel regulatory signals from activator and repressor proteins to affect changes in gene expression programs that control diverse physiological processes, including cell ..
  4. Mediator and epigenetic control of neuronal gene expression and differentiation
    Thomas G Boyer; Fiscal Year: 2010
    ..In this capacity, Mediator serves to channel regulatory signals from activator and repressor proteins to affect changes in gene expression programs that control diverse physiological processes, including cell ..
  5. REGULATION OF DEFENSE SIGNALING IN TOMATO
    Gregg Howe; Fiscal Year: 2009
    ..model systems to develop the hypotheses that COI1 is a receptor for JA-Ile and coronatine, and that JAZ repressor proteins determine the specificity by which SCFCOI1 controls the diversity of jasmonate-regulated processes...
  6. REGULATION OF DEFENSE SIGNALING IN TOMATO
    Gregg A Howe; Fiscal Year: 2010
    ..model systems to develop the hypotheses that COI1 is a receptor for JA-Ile and coronatine, and that JAZ repressor proteins determine the specificity by which SCFCOI1 controls the diversity of jasmonate-regulated processes...
  7. REGULATION OF DEFENSE SIGNALING IN TOMATO
    Gregg A Howe; Fiscal Year: 2010
    ..model systems to develop the hypotheses that COI1 is a receptor for JA-Ile and coronatine, and that JAZ repressor proteins determine the specificity by which SCFCOI1 controls the diversity of jasmonate-regulated processes...
  8. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola C Partridge; Fiscal Year: 2010
    ..and PTH causes the stepwise modification of the chromatin though dissociation of histone deacetylases and co-repressor proteins and association of HATs and activator proteins...
  9. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2009
    ..and PTH causes the stepwise modification of the chromatin though dissociation of histone deacetylases and co-repressor proteins and association of HATs and activator proteins...
  10. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2007
    ..and PTH causes the stepwise modification of the chromatin though dissociation of histone deacetylases and co-repressor proteins and association of HATs and activator proteins...
  11. Purchase of Analytical Ultracentrifuge for Molecular Biophysics at Florida State
    TIMOTHY LOGAN; Fiscal Year: 2007
    ..NIH funded projects that will be enhanced by this equipment include: metal activation of repressor proteins obtained from Corynebacterium diphtheriae, Mycobacterium tuberculosis, and Bacillus anthracis, the assembly ..
  12. TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTS
    Jeffrey Simon; Fiscal Year: 1999
    ..This research will investigate the individual roles of PcG repressor proteins. The work will focus on two of the PcG products, extra sex combs (esc) protein and Sex comb on midleg (Scm) ..
  13. REGULATION OF GENE EXPRESSION BY RETINOID RECEPTORS
    Christopher Glass; Fiscal Year: 2000
    ..is that transcriptional activation and repression by RAR is mediated through distinct co-activator and co-repressor proteins that interact with nuclear receptor heterodimers in a manner that is controlled by ligand, heterodimer ..
  14. TRANSCRIPTIONAL REPRESSION AND ACTIVATION BY YY1
    Yang Shi; Fiscal Year: 1999
    ..Despite the important roles repressor proteins are likely to play, very few of them have been identified and studied in eukaryotic cells...
  15. Use of dominant repressor alleles for non-antibiotic selection in Yersinia pestis
    Gregory Phillips; Fiscal Year: 2007
    ..This research seeks to test the main hypothesis that mutant repressor proteins will function as selectable markers by imparting resistance to potent metabolic inhibitors...
  16. TRANSCRIPTIONAL REGULATION OF CARDIOMYOCYTE DEVELOPMENT
    Gordon Huggins; Fiscal Year: 2003
    ..molecular mechanisms by which GATA proteins, in conjunction with other transcriptionfactors and coactivator/ repressor proteins regulate cardiogenesis and cardiac hypertrophy...
  17. REGULATION OF HUMAN CYTOMEGALOVIRUS GENE EXPRESSION
    Mark Stinski; Fiscal Year: 1999
    ..In higher eucaryotes, little is known about silencer elements, DNA binding-dependent repressor proteins, and the mechanism of transcriptional repression...
  18. In Vitro Reconstitution of Alpha Fetroprotein Regulation
    Michelle Barton; Fiscal Year: 2007
    ..to loss of AFP transcription repression by facilitating alterations of chromatin structure and depletion of repressor proteins. Our experiments will take advantage of in vitro chromatin and synthetic nuclei transcription systems used ..
  19. SPECIFIC REPRESSION OF PROLACTIN GENE EXPRESSION
    Richard Day; Fiscal Year: 2007
    ..This activation is counter-balanced by the association of Pit 1 with the nuclear co-repressor proteins including N-CoR and SMRT...
  20. CHROMOSOMAL REPRESSION OF THE YEAST SILENT MATING LOCI
    Michael Grunstein; Fiscal Year: 1993
    ..c) Antibodies to Sir proteins will be used to determine whether these repressor proteins interact directly with silencer chromatin isolated as episomes and in particular whether they interact with ..
  21. CHROMOSOMAL REPRESSION OF YEAST HETEROCHROMATIN
    Michael Grunstein; Fiscal Year: 2002
    ..from the discovery that certain histone N termini interact genetically and biochemically with specific Sir repressor proteins to repress and localize heterochromatin at the nuclear periphery in yeast...
  22. HDAC3 in COLON CANCER
    John M Mariadason; Fiscal Year: 2010
    ..Specifically, the role of the co-repressor proteins NCoR and SMRT and that of other class I and II HDACs in mediating the HDAC3 response will be addressed using ..
  23. REPRESSOR AND ANTIREPRESSOR PROTEINS OF BACTERIOPHAGES
    Robert Sauer; Fiscal Year: 1993
    ..described in this proposal is to understand the relationship between the sequences and structures of repressor proteins and their DNA recognition and gene regulatory activities ...
  24. Regulation of gene expression in Borrelia burgdorferi
    D Samuels; Fiscal Year: 2006
    ..hypothesis that cis-acting factors, such as DNA supercoiling, and trans-acting factors, such as DNA-binding repressor proteins, regulate the expression of outer surface protein genes in response to environmental signals...
  25. Regulation of gene expression in Borrelia burgdorferi
    D Samuels; Fiscal Year: 2007
    ..hypothesis that cis-acting factors, such as DNA supercoiling, and trans-acting factors, such as DNA-binding repressor proteins, regulate the expression of outer surface protein genes in response to environmental signals...
  26. HTS for Androgen Receptor Antagonists that Recruit NCoR
    Steven Balk; Fiscal Year: 2006
    ..We have shown that AR can interact with co-repressor proteins, including NCoR and SMRT, and that this interaction is enhanced by mifepristone (RU486), demonstrating that ..
  27. HDAC3 in COLON CANCER
    John Mariadason; Fiscal Year: 2007
    ..Specifically, the role of the co-repressor proteins NCoR and SMRT and that of other class I and II HDACs in mediating the HDAC3 response will be addressed using ..