repressor proteins

Summary

Summary: Proteins which are normally bound to the operator locus of an operon, thereby preventing transcription of the structural genes. In enzyme induction, the substrate of the inducible enzyme binds to the repressor protein, causing its release from the operator and freeing the structural genes for transcription. In enzyme repression, the end product of the enzyme sequence binds to the free repressor protein, the resulting complex then binds to the operator and prevents transcription of the structural genes.

Top Publications

  1. pmc Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    John L Rinn
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:1311-23. 2007
  2. pmc The Polycomb complex PRC2 and its mark in life
    Raphael Margueron
    Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    Nature 469:343-9. 2011
  3. pmc CTCF: master weaver of the genome
    Jennifer E Phillips
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Cell 137:1194-211. 2009
  4. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
  5. pmc Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
    Jing Zhao
    Howard Hughes Medical Institute, Boston, MA 02115, USA
    Science 322:750-6. 2008
  6. doi Mechanisms of polycomb gene silencing: knowns and unknowns
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455, USA
    Nat Rev Mol Cell Biol 10:697-708. 2009
  7. pmc Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
    Manching Ku
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA
    PLoS Genet 4:e1000242. 2008
  8. ncbi Genome-wide mapping of in vivo protein-DNA interactions
    David S Johnson
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
    Science 316:1497-502. 2007
  9. pmc CTCF-mediated functional chromatin interactome in pluripotent cells
    Lusy Handoko
    Genome Institute of Singapore, Singapore
    Nat Genet 43:630-8. 2011
  10. pmc Histone deacetylases (HDACs): characterization of the classical HDAC family
    Annemieke J M de Ruijter
    Academic Medical Centre, University of Amsterdam, Amsterdam, The, Netherlands
    Biochem J 370:737-49. 2003

Detail Information

Publications233 found, 100 shown here

  1. pmc Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    John L Rinn
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:1311-23. 2007
    ..Thus, transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance; these results have broad implications for gene regulation in development and disease states...
  2. pmc The Polycomb complex PRC2 and its mark in life
    Raphael Margueron
    Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    Nature 469:343-9. 2011
    ..Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes...
  3. pmc CTCF: master weaver of the genome
    Jennifer E Phillips
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Cell 137:1194-211. 2009
    ....
  4. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
    ....
  5. pmc Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
    Jing Zhao
    Howard Hughes Medical Institute, Boston, MA 02115, USA
    Science 322:750-6. 2008
    ..Likewise, PRC2 deficiency compromises Xist up-regulation. Therefore, RepA, together with PRC2, is required for the initiation and spread of XCI. We conclude that a ncRNA cofactor recruits Polycomb complexes to their target locus...
  6. doi Mechanisms of polycomb gene silencing: knowns and unknowns
    Jeffrey A Simon
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455, USA
    Nat Rev Mol Cell Biol 10:697-708. 2009
    ..These findings have an impact on the epigenetic programming of gene expression in many biological systems...
  7. pmc Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
    Manching Ku
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA
    PLoS Genet 4:e1000242. 2008
    ..We propose that large CpG islands depleted of activating motifs confer epigenetic memory by recruiting the full repertoire of Polycomb complexes in pluripotent cells...
  8. ncbi Genome-wide mapping of in vivo protein-DNA interactions
    David S Johnson
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
    Science 316:1497-502. 2007
    ..96] and statistical confidence (P <10(-4)), properties that were important for inferring new candidate interactions. These include key transcription factors in the gene network that regulates pancreatic islet cell development...
  9. pmc CTCF-mediated functional chromatin interactome in pluripotent cells
    Lusy Handoko
    Genome Institute of Singapore, Singapore
    Nat Genet 43:630-8. 2011
    ..This highly complex nuclear organization offers insights toward the unifying principles that govern genome plasticity and function...
  10. pmc Histone deacetylases (HDACs): characterization of the classical HDAC family
    Annemieke J M de Ruijter
    Academic Medical Centre, University of Amsterdam, Amsterdam, The, Netherlands
    Biochem J 370:737-49. 2003
    ..This challenging field has generated many fascinating results which will ultimately lead to a better understanding of the mechanism of gene transcription as a whole...
  11. ncbi JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling
    Bryan Thines
    Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164 6340, USA
    Nature 448:661-5. 2007
    ....
  12. pmc Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter
    L M Guzman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 177:4121-30. 1995
    ..We have exploited the tight regulation of the PBAD promoter to study the phenotypes of null mutations of essential genes and explored the use of pBAD vectors as an expression system...
  13. pmc GC-rich sequence elements recruit PRC2 in mammalian ES cells
    Eric M Mendenhall
    Howard Hughes Medical Institute and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1001244. 2010
    ....
  14. doi ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    Aaron A Goodarzi
    Genome Damage and Stability Centre, University of Sussex, East Sussex BN1 9RQ, UK
    Mol Cell 31:167-77. 2008
    ..These data suggest that the importance of ATM signaling for DSB repair increases as the heterochromatic component of a genome expands...
  15. pmc The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease
    Amy N Packer
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 28:14341-6. 2008
    ..These data provide evidence for a double negative feedback loop between the REST silencing complex and the miRNAs it regulates...
  16. pmc Cellular defenses against superoxide and hydrogen peroxide
    James A Imlay
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Annu Rev Biochem 77:755-76. 2008
    ..Current research seeks to identify these, and bacteria comprise an exceptionally accessible experimental system that has provided many of the answers. This manuscript reviews recent developments and identifies remaining puzzles...
  17. ncbi Genome regulation by polycomb and trithorax proteins
    Bernd Schuettengruber
    Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Cell 128:735-45. 2007
    ..Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery...
  18. ncbi Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    X Nan
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Nature 393:386-9. 1998
    ..The data suggest that two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can be linked by MeCP2...
  19. pmc Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    Kai Hildner
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 322:1097-100. 2008
    ..Importantly, rejection of highly immunogenic syngeneic tumors was impaired in Batf3-/- mice. These results suggest an important role for CD8alpha+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection...
  20. ncbi Polycomb complexes repress developmental regulators in murine embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 441:349-53. 2006
    ..Our results indicate that dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development...
  21. ncbi Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    Birgit Czermin
    Adolf Butenandt Institut, University of Munich, Schillerstrasse 44, 80336 Munich, Germany
    Cell 111:185-96. 2002
    ..Histone H3 methylated in vitro by the E(Z)/ESC complex binds specifically to Polycomb protein...
  22. doi Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
    Fabio Mohn
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Mol Cell 30:755-66. 2008
    ..These data suggest a model how de novo DNA methylation and dynamic switches in Polycomb targets restrict pluripotency and define the developmental potential of progenitor cells...
  23. doi Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    Jakub Godlewski
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, Ohio 43210
    Cancer Res 68:9125-30. 2008
    ....
  24. pmc Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states
    Katsuhiko Hayashi
    Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell Stem Cell 3:391-401. 2008
    ....
  25. ncbi The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    M Scheffner
    Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892
    Cell 75:495-505. 1993
    ..The ubiquitination of p53 requires the E1 enzyme and a novel E2 in mammalian cells, while E3 activity is conferred by the E6-E6-AP complex. Furthermore, E6-AP appears to have ubiquitin-protein ligase activity in the absence of E6...
  26. ncbi HES and HERP families: multiple effectors of the Notch signaling pathway
    Tatsuya Iso
    Institute for Genetic Medicine, Department of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA
    J Cell Physiol 194:237-55. 2003
    ..The identification of the HERP family as a Notch effector that cooperates with HES/E(spl) family has opened a new avenue to our understanding of the Notch signaling pathway...
  27. doi A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
    Na Yu Chia
    Gene Regulation Laboratory, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672
    Nature 468:316-20. 2010
    ..Altogether, our study uncovers a wealth of novel hESC regulators wherein PRDM14 exemplifies a key transcription factor required for the maintenance of hESC identity and the reacquisition of pluripotency in human somatic cells...
  28. ncbi Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
    Ann M Sheehy
    Department of Microbiology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 418:646-50. 2002
    ..Because the Vif:CEM15 regulatory circuit is critical for HIV-1 replication, perturbing the circuit may be a promising target for future HIV/AIDS therapies...
  29. pmc Polycomb complexes act redundantly to repress genomic repeats and genes
    Martin Leeb
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Genes Dev 24:265-76. 2010
    ..This indicates a contribution of the Polycomb group system to the defense against parasitic DNA, and a potential role of genomic repeats in Polycomb-mediated gene regulation...
  30. ncbi Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Cancer Res 66:6225-32. 2006
    ....
  31. ncbi Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
    T Lee
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 22:451-61. 1999
    ..As an example, we show that the short stop gene is required in mushroom body neurons for the extension and guidance of their axons...
  32. ncbi Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
    P L Jones
    Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20892 5431, USA
    Nat Genet 19:187-91. 1998
    ..These results establish a direct causal relationship between DNA methylation-dependent transcriptional silencing and the modification of chromatin...
  33. ncbi A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    J Guy
    Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, The King s Buildings, Edinburgh, UK
    Nat Genet 27:322-6. 2001
    ....
  34. pmc Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
    Raphael Margueron
    Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, NY 10016, USA
    Mol Cell 32:503-18. 2008
    ..These results might reflect subfunctionalization of a PcG protein during evolution...
  35. pmc The TetR family of transcriptional repressors
    Juan L Ramos
    Department of Plant Biochemistry and Molecular and Cellular Biology, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Granada, Spain
    Microbiol Mol Biol Rev 69:326-56. 2005
    ..Information related to the TetR family of regulators has been updated in a database that can be accessed at www.bactregulators.org...
  36. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  37. pmc Quorum-sensing regulators control virulence gene expression in Vibrio cholerae
    Jun Zhu
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:3129-34. 2002
    ..Together these data suggest a role for quorum sensing in modulating expression of blocks of virulence genes in a reciprocal fashion in vivo...
  38. doi Polycomb group proteins: navigators of lineage pathways led astray in cancer
    Adrian P Bracken
    The Smurfit Institute of Genetics, Trinity College Dublin and The Adelaide and Meath Hospital, including The National Children s Hospital, Dublin, Ireland
    Nat Rev Cancer 9:773-84. 2009
    ..We also speculate about how their deregulation contributes to tumorigenesis...
  39. pmc Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    Ahmad M Khalil
    The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:11667-72. 2009
    ..We propose a model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression...
  40. pmc Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing
    Céline Marban
    INSERM unité 575 Pathophysiology of Nervous System, Centre de Neurochimie, Strasbourg, France
    EMBO J 26:412-23. 2007
    ..Altogether, our findings uncover new therapeutic opportunities for purging latent HIV-1 viruses from their cellular reservoirs...
  41. ncbi The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    E Batlle
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain
    Nat Cell Biol 2:84-9. 2000
    ..Inhibition of Snail function in epithelial cancer cell lines lacking E-cadherin protein restores the expression of the E-cadherin gene...
  42. doi KAP1 controls endogenous retroviruses in embryonic stem cells
    Helen M Rowe
    School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nature 463:237-40. 2010
    ..Correspondingly, IAP 5'UTR sequences can impose in cis KAP1-dependent repression on a heterologous promoter in ES cells. Our results establish that KAP1 controls endogenous retroelements during early embryonic development...
  43. ncbi Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0946, USA
    Cancer Res 66:6063-71. 2006
    ..These studies support a cancer stem cell model in which the hedgehog pathway and Bmi-1 play important roles in regulating self-renewal of normal and tumorigenic human mammary stem cells...
  44. pmc YY1 tethers Xist RNA to the inactive X nucleation center
    Yesu Jeon
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Cell 146:119-33. 2011
    ..Specific YY1-to-RNA and YY1-to-DNA contacts are required to load Xist particles onto X. YY1 interacts with Xist RNA through Repeat C. We propose that YY1 acts as adaptor between regulatory RNA and chromatin targets...
  45. pmc Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
    Janghoo Lim
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 452:713-8. 2008
    ..This model provides mechanistic insight into the molecular pathogenesis of SCA1 as well as other polyglutamine diseases...
  46. pmc A region of the human HOXD cluster that confers polycomb-group responsiveness
    Caroline J Woo
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 140:99-110. 2010
    ..We conclude that D11.12 is a Polycomb-dependent regulatory region with similarities to Drosophila PREs, indicating conservation in the mechanisms that target PcG function in mammals and flies...
  47. doi JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
    Diego Pasini
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark
    Nature 464:306-10. 2010
    ..Thus, these results demonstrate that JARID2 is essential for the binding of PcG proteins to target genes and, consistent with this, for the proper differentiation of embryonic stem cells and normal development...
  48. pmc Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 207:823-36. 2010
    ..These data provide evidence for a developmental relationship between lymphoid organ-resident CD8alpha+ cDCs and nonlymphoid CD103+ DCs...
  49. pmc Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
    Jamy C Peng
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 139:1290-302. 2009
    ..Our findings illuminate a mechanism of histone methylation regulation in pluripotent cells and during early cell-fate transitions...
  50. ncbi Differentiation of mouse embryonic stem cells into a defined neuronal lineage
    Miriam Bibel
    Friedrich Miescher Institute, CH 4058 Basel, Switzerland
    Nat Neurosci 7:1003-9. 2004
    ..As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics...
  51. pmc Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
    Ragnhild Eskeland
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Mol Cell 38:452-64. 2010
    ..We suggest that Ring1B-mediated chromatin compaction acts to directly limit transcription in vivo...
  52. ncbi Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
    Julie K Stock
    Nuclear Organisation, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 9:1428-35. 2007
    ..These observations provide an insight into the molecular mechanisms that allow ES cells to self-renew and yet retain the ability to generate multiple lineage outcomes...
  53. ncbi Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
    A C Bell
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Nature 405:482-5. 2000
    ..Our results reveal that DNA methylation can control gene expression by modulating enhancer access to the gene promoter through regulation of an enhancer boundary...
  54. ncbi Signalling downstream of activated mammalian Notch
    S Jarriault
    Unité de Biologie Moléculaire de l Expression Génique, URA 1149 CNRS, Institut Pasteur, Paris, France
    Nature 377:355-8. 1995
    ..Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-J kappa (refs 8,9) and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter...
  55. pmc Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells
    Xiaohua Shen
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Cell 139:1303-14. 2009
    ..Our results demonstrate that dynamic regulation of Polycomb complex activity orchestrated by JMJ balances self-renewal and differentiation, highlighting the involvement of chromatin dynamics in cell-fate transitions...
  56. ncbi Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    R E Amir
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 23:185-8. 1999
    ..This suggests that the mother is a germline mosaic for this mutation. Our study reports the first disease-causing mutations in RTT and points to abnormal epigenetic regulation as the mechanism underlying the pathogenesis of RTT...
  57. ncbi The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
    C Sidrauski
    Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco 94143 0448, USA
    Cell 90:1031-9. 1997
    ..The addition of purified tRNA ligase completes splicing; we therefore have reconstituted HAC1 mRNA splicing in vitro from purified components...
  58. pmc An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b
    Long Li
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Science 329:89-93. 2010
    ....
  59. ncbi The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
    Francesca De Santa
    Department of Experimental Oncology, European Institute of Oncology, Campus IFOM IEO, Via Adamello 16, 20139 Milan, Italy
    Cell 130:1083-94. 2007
    ....
  60. ncbi CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
    Y Kawaguchi
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Nat Genet 8:221-8. 1994
    ..Southern blot analyses and genomic cloning demonstrates the existence of related genes. These results raise the possibility that similar abnormalities in related genes may give rise to diseases similar to MJD...
  61. ncbi Engineering stability in gene networks by autoregulation
    A Becskei
    EMBL, Structures and Biocomputing, Heidelberg, Germany
    Nature 405:590-3. 2000
    ..Here we have designed and constructed simple gene circuits consisting of a regulator and transcriptional repressor modules in Escherichia coli and we show the gain of stability produced by negative feedback...
  62. pmc Role of the polycomb protein EED in the propagation of repressive histone marks
    Raphael Margueron
    Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, New York 10016, USA
    Nature 461:762-7. 2009
    ..These findings suggest a model for the propagation of the H3K27me3 mark that accounts for the maintenance of repressive chromatin domains and for the transmission of a histone modification from mother to daughter cells...
  63. pmc Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    Adrian P Bracken
    Biotech Research and Innovation Centre BRIC, 2100 Copenhagen Ø, Denmark
    Genes Dev 20:1123-36. 2006
    ....
  64. pmc The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression
    Subhashini Sadasivam
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 26:474-89. 2012
    ..Our results reveal a novel role for the MuvB complex in recruiting B-Myb and FoxM1 to promote late cell cycle gene expression and in regulating cell cycle gene expression from quiescence through mitosis...
  65. pmc Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2
    Aditi Kanhere
    Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Mol Cell 38:675-88. 2010
    ..We propose that short RNAs play a role in the association of PRC2 with its target genes...
  66. ncbi Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes
    Jose Silva
    X Inactivation Group, MRC Clinical Sciences Centre, ICSM, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Dev Cell 4:481-95. 2003
    ..Functional analysis demonstrates that Eed-Enx1 is required to establish methylation of histone H3 at lysine 9 and/or lysine 27 on Xi and that this, in turn, is required to stabilize the Xi chromatin structure...
  67. pmc A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
    Xin Zeng
    Neurobiology Program, Children s Hospital Boston, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 438:873-7. 2005
    ....
  68. pmc Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice
    Jongdae Shin
    Program in Gene Function and Expression, University of Massachusetts Medical School UMMS, Worcester, Massachusetts 01605, USA
    Nature 467:977-81. 2010
    ..These results assign crucial functions to the maternal deposit of Rnf12/RLIM for the initiation of imprinted XCI...
  69. pmc CTCF physically links cohesin to chromatin
    Eric D Rubio
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle WA 98195, USA
    Proc Natl Acad Sci U S A 105:8309-14. 2008
    ..These results have implications for the functional role of cohesin subunits in the pathogenesis of Cornelia de Lange syndrome and Roberts syndromes...
  70. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  71. pmc The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 22:894-907. 2008
    ..Conversely, inhibition of miR-200 reduced E-cadherin expression, increased expression of Vimentin, and induced EMT. Our data identify miR-200 as a powerful marker and determining factor of the epithelial phenotype of cancer cells...
  72. ncbi Stochastic gene expression in a single cell
    Michael B Elowitz
    Laboratory of Cancer Biology, Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10021, USA
    Science 297:1183-6. 2002
    ..These results establish a quantitative foundation for modeling noise in genetic networks and reveal how low intracellular copy numbers of molecules can fundamentally limit the precision of gene regulation...
  73. ncbi Functional specialization within the Fur family of metalloregulators
    Jin Won Lee
    Department of Microbiology, Cornell University, Wing Hall, Ithaca, NY 14853 8101, USA
    Biometals 20:485-99. 2007
    ..Despite numerous studies, the mechanism of metal ion sensing by Fur family proteins is still controversial. Other family members use metal catalyzed oxidation reactions to sense peroxide-stress (PerR) or the availability of heme (Irr)...
  74. doi FOXP2 as a molecular window into speech and language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Genet 25:166-77. 2009
    ..This body of research represents the first functional genetic forays into neural mechanisms contributing to human spoken language...
  75. ncbi Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
    Michel Warny
    Acambis Inc, Cambridge, MA, USA
    Lancet 366:1079-84. 2005
    ..We characterised the dominant strain of this epidemic to determine whether it produces higher amounts of toxins A and B than those produced by non-epidemic strains...
  76. pmc Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding
    Nathan P Gomes
    Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 24:1022-34. 2010
    ..Therefore, CTCF plays a pivotal role in dampening the p53 apoptotic response by acting as a gene-specific repressor...
  77. pmc Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase
    Inmaculada Hernández-Muñoz
    Division of Molecular Genetics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:7635-40. 2005
    ..We further demonstrate that MACROH2A1 deposition is regulated by the CULLIN3/SPOP ligase complex and is actively involved in stable X inactivation, likely through the formation of an additional layer of epigenetic silencing...
  78. pmc Repression of FLOWERING LOCUS C and FLOWERING LOCUS T by the Arabidopsis Polycomb repressive complex 2 components
    Danhua Jiang
    Department of Biological Sciences, National University of Singapore, Singapore, Republic of Singapore
    PLoS ONE 3:e3404. 2008
    ..Given the central roles of FLC and FT in flowering-time regulation in Arabidopsis, these findings suggest that the CLF-containing PRC2-like complexes play a significant role in control of flowering in Arabidopsis...
  79. doi Bmi1 regulates mitochondrial function and the DNA damage response pathway
    Jie Liu
    Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 459:387-92. 2009
    ....
  80. ncbi Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
    Raffaella Villa
    Centre de Regulacio Genomica, C Dr Aiguader 88, 08003 Barcelona, Spain
    Cancer Cell 11:513-25. 2007
    ..Our results demonstrate that the direct targeting of Polycomb group proteins by an oncogene plays a key role during carcinogenesis...
  81. ncbi Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly
    I M Hanson
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Nat Genet 6:168-73. 1994
    ..We therefore propose that a variety of anterior segment anomalies may be associated with PAX6 mutations...
  82. pmc The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting
    Mary E Donohoe
    Howard Hughes Medical Institute, USA
    Nature 460:128-32. 2009
    ..Thus, we have identified the first trans-factor that regulates counting, and ascribed new functions to Oct4 during X-chromosome reprogramming...
  83. ncbi TSC2 mediates cellular energy response to control cell growth and survival
    Ken Inoki
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 115:577-90. 2003
    ..These observations demonstrate a model where TSC2 functions as a key player in regulation of the common mTOR pathway of protein synthesis, cell growth, and viability in response to cellular energy levels...
  84. pmc Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs
    Henriette O'Geen
    Department of Pharmacology, University of California Davis, Davis, California, United States of America
    PLoS Genet 3:e89. 2007
    ..Because KAP1 is recruited to the DNA via interaction with KRAB-ZNF proteins, we suggest that expression of KRAB-ZNF genes may be controlled via an auto-regulatory mechanism involving KAP1...
  85. pmc Cleavage of bacteriophage lambda cI repressor involves the RecA C-terminal domain
    Vitold E Galkin
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908 0733, USA
    J Mol Biol 385:779-87. 2009
    ..Under conditions where the repressor cleavage rates are the highest, cI is coordinated within the groove by contacts with RecA's CTD. These observations provide a framework for understanding previous genetic and biochemical observations...
  86. pmc A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation
    D Beckett
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore 21250, USA
    Protein Sci 8:921-9. 1999
    ..We conclude that the 14-mer peptide efficiently mimics the biotin acceptor function of the much larger protein domain normally recognized by BirA...
  87. doi Crystal structure of the Vibrio cholerae ferric uptake regulator (Fur) reveals insights into metal co-ordination
    Md Arif Sheikh
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK
    Mol Microbiol 72:1208-20. 2009
    ..An analysis of the metal binding properties shows that V. cholerae Fur can be activated by a range of divalent metals...
  88. ncbi Pax 6: mastering eye morphogenesis and eye evolution
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Trends Genet 15:371-7. 1999
    ..It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution...
  89. doi Polycomb group protein-mediated repression of transcription
    Lluis Morey
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Trends Biochem Sci 35:323-32. 2010
    ....
  90. ncbi Bypassing a kinase activity with an ATP-competitive drug
    Feroz R Papa
    Department of Medicine, University of California, San Francisco, CA 94143 2200, USA
    Science 302:1533-7. 2003
    ..Thus, rather than through phosphorylation per se, a conformational change in the kinase domain triggered by occupancy of the active site with a ligand leads to activation of all known downstream functions...
  91. pmc The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    J Clin Invest 119:3626-36. 2009
    ..Our results provide functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer...
  92. doi MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases
    Jennifer M Doyle
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    Mol Cell 39:963-74. 2010
    ..For example, MAGE-C2-TRIM28 is shown to target p53 for degradation in a proteasome-dependent manner, consistent with its tumorigenic functions. These findings define a biochemical and cellular function for the MAGE protein family...
  93. pmc Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila
    Julide Bilen
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Genet 3:1950-64. 2007
    ..These findings provide new insight into molecular pathways of polyQ toxicity, defining novel targets for promoting neuronal survival in human neurodegenerative disease...
  94. doi Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice
    Bernd Schuettengruber
    Institut de Genetique Humaine, CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Development 136:3531-42. 2009
    ..Finally, we focus on the dynamics of PcG protein complex action during cell fate transitions and on the implications of histone modifications for cell lineage commitment...
  95. pmc KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading
    Anna C Groner
    School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    PLoS Genet 6:e1000869. 2010
    ..This finding not only suggests auto-regulatory mechanisms in the control of KRAB-ZFP gene clusters, but also provides important cues for interpreting future genome-wide DNA binding data of KRAB-ZFPs and KAP1...
  96. pmc Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
    Ji Won Jung
    Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
    Cell Mol Life Sci 67:1165-76. 2010
    ..These results suggest that HDAC activity might be important for MSC self-renewal by balancing PcGs and JMJD3 expression, which govern cellular senescence by p16(INK4A) regulation...
  97. ncbi Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice
    Yoshiyuki Seki
    Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology, RIKEN Kobe Institute, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
    Development 134:2627-38. 2007
    ..We suggest the possibility that active repression of an essential enzyme and subsequent unique cellular dynamics ensures successful implementation of genome-wide epigenetic reprogramming in migrating PGCs...
  98. doi Regulatory circuits in Helicobacter pylori : network motifs and regulators involved in metal-dependent responses
    Alberto Danielli
    Department of Biology, University of Bologna, Bologna, Italy
    FEMS Microbiol Rev 34:738-52. 2010
    ..These motifs appear to confer versatile dynamics of metal-dependent responses by extensive horizontal connections between the regulators and feedback control of metal-cofactor availability...
  99. ncbi The many roles of the transcriptional regulator CTCF
    Katherine L Dunn
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Biochem Cell Biol 81:161-7. 2003
    ..Recent studies have provided new insight into the mechanism through which this factor acts at various levels of gene regulation...
  100. pmc Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary
    Michael Witcher
    Regulatory Biology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Mol Cell 34:271-84. 2009
    ....
  101. ncbi decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
    T Xie
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Cell 94:251-60. 1998
    ..We constructed mutant germline stem cell clones to show that the dpp signal is directly received by germline stem cells. Thus, dpp signaling helps define a niche that controls germline stem cell proliferation...

Research Grants76

  1. Targeting DNA Secondary Structures for Bcl-2 Gene Regulation
    Danzhou Yang; Fiscal Year: 2010
    ..a manner analogous to the genetic switch in the bacteriophage lambda controlled by the interactive Cro and Repressor proteins, whose operator regions (ORs) overlap with each other's promoter regions and thereby inhibit each other&..
  2. DRUG SENSITIVITY OF CALCIUM MODULATORS FROM BRAIN TUMORS
    William Hait; Fiscal Year: 2000
    ..The decreased protein synthesis, perhaps through degradation of short-lived repressor proteins, allows cell division to proceed in a variety of experimental systems...
  3. Mediator and epigenetic control of neuronal gene expression and differentiation
    Thomas G Boyer; Fiscal Year: 2010
    ..In this capacity, Mediator serves to channel regulatory signals from activator and repressor proteins to affect changes in gene expression programs that control diverse physiological processes, including cell ..
  4. Mediator and epigenetic control of neuronal gene expression and differentiation
    Thomas Boyer; Fiscal Year: 2009
    ..In this capacity, Mediator serves to channel regulatory signals from activator and repressor proteins to affect changes in gene expression programs that control diverse physiological processes, including cell ..
  5. REGULATION OF DEFENSE SIGNALING IN TOMATO
    Gregg A Howe; Fiscal Year: 2010
    ..model systems to develop the hypotheses that COI1 is a receptor for JA-Ile and coronatine, and that JAZ repressor proteins determine the specificity by which SCFCOI1 controls the diversity of jasmonate-regulated processes...
  6. REGULATION OF DEFENSE SIGNALING IN TOMATO
    Gregg Howe; Fiscal Year: 2009
    ..model systems to develop the hypotheses that COI1 is a receptor for JA-Ile and coronatine, and that JAZ repressor proteins determine the specificity by which SCFCOI1 controls the diversity of jasmonate-regulated processes...
  7. REGULATION OF DEFENSE SIGNALING IN TOMATO
    Gregg A Howe; Fiscal Year: 2010
    ..model systems to develop the hypotheses that COI1 is a receptor for JA-Ile and coronatine, and that JAZ repressor proteins determine the specificity by which SCFCOI1 controls the diversity of jasmonate-regulated processes...
  8. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2009
    ..and PTH causes the stepwise modification of the chromatin though dissociation of histone deacetylases and co-repressor proteins and association of HATs and activator proteins...
  9. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola C Partridge; Fiscal Year: 2010
    ..and PTH causes the stepwise modification of the chromatin though dissociation of histone deacetylases and co-repressor proteins and association of HATs and activator proteins...
  10. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2007
    ..and PTH causes the stepwise modification of the chromatin though dissociation of histone deacetylases and co-repressor proteins and association of HATs and activator proteins...
  11. Purchase of Analytical Ultracentrifuge for Molecular Biophysics at Florida State
    TIMOTHY LOGAN; Fiscal Year: 2007
    ..NIH funded projects that will be enhanced by this equipment include: metal activation of repressor proteins obtained from Corynebacterium diphtheriae, Mycobacterium tuberculosis, and Bacillus anthracis, the assembly ..
  12. TRANSCRIPTIONAL REPRESSION BY POLYCOMB GROUP PRODUCTS
    Jeffrey Simon; Fiscal Year: 1999
    ..This research will investigate the individual roles of PcG repressor proteins. The work will focus on two of the PcG products, extra sex combs (esc) protein and Sex comb on midleg (Scm) ..
  13. REGULATION OF GENE EXPRESSION BY RETINOID RECEPTORS
    Christopher Glass; Fiscal Year: 2000
    ..is that transcriptional activation and repression by RAR is mediated through distinct co-activator and co-repressor proteins that interact with nuclear receptor heterodimers in a manner that is controlled by ligand, heterodimer ..
  14. TRANSCRIPTIONAL REPRESSION AND ACTIVATION BY YY1
    Yang Shi; Fiscal Year: 1999
    ..Despite the important roles repressor proteins are likely to play, very few of them have been identified and studied in eukaryotic cells...
  15. Use of dominant repressor alleles for non-antibiotic selection in Yersinia pestis
    Gregory Phillips; Fiscal Year: 2007
    ..This research seeks to test the main hypothesis that mutant repressor proteins will function as selectable markers by imparting resistance to potent metabolic inhibitors...
  16. TRANSCRIPTIONAL REGULATION OF CARDIOMYOCYTE DEVELOPMENT
    Gordon Huggins; Fiscal Year: 2003
    ..molecular mechanisms by which GATA proteins, in conjunction with other transcriptionfactors and coactivator/ repressor proteins regulate cardiogenesis and cardiac hypertrophy...
  17. REGULATION OF HUMAN CYTOMEGALOVIRUS GENE EXPRESSION
    Mark Stinski; Fiscal Year: 1999
    ..In higher eucaryotes, little is known about silencer elements, DNA binding-dependent repressor proteins, and the mechanism of transcriptional repression...
  18. In Vitro Reconstitution of Alpha Fetroprotein Regulation
    Michelle Barton; Fiscal Year: 2007
    ..to loss of AFP transcription repression by facilitating alterations of chromatin structure and depletion of repressor proteins. Our experiments will take advantage of in vitro chromatin and synthetic nuclei transcription systems used ..
  19. CHROMOSOMAL REPRESSION OF THE YEAST SILENT MATING LOCI
    Michael Grunstein; Fiscal Year: 1993
    ..c) Antibodies to Sir proteins will be used to determine whether these repressor proteins interact directly with silencer chromatin isolated as episomes and in particular whether they interact with ..
  20. SPECIFIC REPRESSION OF PROLACTIN GENE EXPRESSION
    Richard Day; Fiscal Year: 2007
    ..This activation is counter-balanced by the association of Pit 1 with the nuclear co-repressor proteins including N-CoR and SMRT...
  21. CHROMOSOMAL REPRESSION OF YEAST HETEROCHROMATIN
    Michael Grunstein; Fiscal Year: 2002
    ..from the discovery that certain histone N termini interact genetically and biochemically with specific Sir repressor proteins to repress and localize heterochromatin at the nuclear periphery in yeast...
  22. REPRESSOR AND ANTIREPRESSOR PROTEINS OF BACTERIOPHAGES
    Robert Sauer; Fiscal Year: 1993
    ..described in this proposal is to understand the relationship between the sequences and structures of repressor proteins and their DNA recognition and gene regulatory activities ...
  23. Regulation of gene expression in Borrelia burgdorferi
    D Samuels; Fiscal Year: 2006
    ..hypothesis that cis-acting factors, such as DNA supercoiling, and trans-acting factors, such as DNA-binding repressor proteins, regulate the expression of outer surface protein genes in response to environmental signals...
  24. Regulation of gene expression in Borrelia burgdorferi
    D Samuels; Fiscal Year: 2007
    ..hypothesis that cis-acting factors, such as DNA supercoiling, and trans-acting factors, such as DNA-binding repressor proteins, regulate the expression of outer surface protein genes in response to environmental signals...
  25. HDAC3 in COLON CANCER
    John M Mariadason; Fiscal Year: 2010
    ..Specifically, the role of the co-repressor proteins NCoR and SMRT and that of other class I and II HDACs in mediating the HDAC3 response will be addressed using ..
  26. HTS for Androgen Receptor Antagonists that Recruit NCoR
    Steven Balk; Fiscal Year: 2006
    ..We have shown that AR can interact with co-repressor proteins, including NCoR and SMRT, and that this interaction is enhanced by mifepristone (RU486), demonstrating that ..
  27. HDAC3 in COLON CANCER
    John Mariadason; Fiscal Year: 2007
    ..Specifically, the role of the co-repressor proteins NCoR and SMRT and that of other class I and II HDACs in mediating the HDAC3 response will be addressed using ..