tissue inhibitor of metalloproteinases

Summary

Summary: A family of secreted proteins (TIMP-1; TIMP-2; and TIMP-3) that play a crucial role in regulating the activity of the secreted METALLOENDOPEPTIDASES; (COLLAGENASES; stromelysins; GELATINASES). Of the three characterized, only TIMP-1 and TIMP-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype in cancer cells. (Pharmacol Ther 1993;59:329-41)

Top Publications

  1. ncbi Structure and function of matrix metalloproteinases and TIMPs
    Hideaki Nagase
    Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Cardiovasc Res 69:562-73. 2006
  2. ncbi Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability
    Andrew C Newby
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Arterioscler Thromb Vasc Biol 28:2108-14. 2008
  3. ncbi Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry
    Robert Visse
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Rd, London W6 8LH, UK
    Circ Res 92:827-39. 2003
  4. ncbi A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
    Jian Hua Qi
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Nat Med 9:407-15. 2003
  5. ncbi The role of IL-18 and IL-12 in the modulation of matrix metalloproteinases and their tissue inhibitors in monocytic cells
    Michal Abraham
    Neuroimmunology and Immunology Research Units, Carmel Medical Center, and Rappaport Institute for Research in the Medical Sciences, and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Int Immunol 14:1449-57. 2002
  6. ncbi Characterization of C-terminally truncated human tissue inhibitor of metalloproteinases-4 expressed in Pichia pastoris
    B Stratmann
    University of Bielefeld, Faculty of Chemistry, Biochemistry I, Germany
    Biol Chem 382:987-91. 2001
  7. ncbi The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology
    E A Baker
    Professorial Unit of Surgery, University Hospital of North Tees, Stockton on Tees, TS19 8P, UK
    Eur J Cancer 39:981-8. 2003
  8. ncbi Evidence of in vitro differential secretion of 72 and 92 kDa type IV collagenases after selective exposure to lipopolysaccharide in human fetal membranes
    Guadalupe Garcia Lopez
    Direction of Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, Mexico
    Mol Hum Reprod 13:409-18. 2007
  9. ncbi Metzincin proteases and their inhibitors: foes or friends in nervous system physiology?
    Santiago Rivera
    Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, Unité Mixte de Recherche 6184, Centre National de la Recherche Scientifique, Universite de la Mediterranee, 13344 Marseille, France
    J Neurosci 30:15337-57. 2010
  10. ncbi MMP/TIMP imbalance in amniotic fluid during PROM: an indirect support for endogenous pathway to membrane rupture
    S J Fortunato
    Perinatal Research Center, Women s Health Research and Education Foundation, Nashville, TN, USA
    J Perinat Med 27:362-8. 1999

Research Grants

  1. METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWN
    Hideaki Nagase; Fiscal Year: 1993
  2. Matrix Metalloproteinases and the Blood-Brain Barrier
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
  3. Sertoli cell injury and mechanisms of testicular germ cell apoptosis
    John H Richburg; Fiscal Year: 2010
  4. ALPHA-2 MACROGLOBULIN RECEPTOR, RAP, AND PREECLAMPSIA
    Dudley Strickland; Fiscal Year: 1993
  5. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2006
  6. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    Cindy Morris; Fiscal Year: 2009
  7. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    Cindy Morris; Fiscal Year: 2009
  8. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2006
  9. DNA CAPILLARY ELECTROPHORESIS PROTOCOLS AND PROCESSES
    Michael Morris; Fiscal Year: 2002
  10. COLLAGENOLYSIS-DRIVEN MOLECULAR MOTORS IN CELL MIGRATION AND MATRIX REMODELING
    Gregory I Goldberg; Fiscal Year: 2010

Detail Information

Publications259 found, 100 shown here

  1. ncbi Structure and function of matrix metalloproteinases and TIMPs
    Hideaki Nagase
    Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Cardiovasc Res 69:562-73. 2006
    ..This review introduces the members of the MMP family and discusses their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology...
  2. ncbi Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability
    Andrew C Newby
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Arterioscler Thromb Vasc Biol 28:2108-14. 2008
    ..Moreover, recent evidence suggests that different macrophage phenotypes express characteristically different spectra of MMPs and their inhibitors. New therapies may result from targeting matrix MMP overproduction...
  3. ncbi Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry
    Robert Visse
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Rd, London W6 8LH, UK
    Circ Res 92:827-39. 2003
    ....
  4. ncbi A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
    Jian Hua Qi
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Nat Med 9:407-15. 2003
    b>Tissue inhibitor of metalloproteinases-3 (TIMP3) is one of four members of a family of proteins that were originally classified according to their ability to inhibit matrix metalloproteinases (MMP)...
  5. ncbi The role of IL-18 and IL-12 in the modulation of matrix metalloproteinases and their tissue inhibitors in monocytic cells
    Michal Abraham
    Neuroimmunology and Immunology Research Units, Carmel Medical Center, and Rappaport Institute for Research in the Medical Sciences, and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Int Immunol 14:1449-57. 2002
    ....
  6. ncbi Characterization of C-terminally truncated human tissue inhibitor of metalloproteinases-4 expressed in Pichia pastoris
    B Stratmann
    University of Bielefeld, Faculty of Chemistry, Biochemistry I, Germany
    Biol Chem 382:987-91. 2001
    ..With dissociation constants in the nanomolar range, TIMP-4 seems to be a good inhibitor for all classes of MMPs without remarkable preference for special MMPs...
  7. ncbi The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology
    E A Baker
    Professorial Unit of Surgery, University Hospital of North Tees, Stockton on Tees, TS19 8P, UK
    Eur J Cancer 39:981-8. 2003
    ....
  8. ncbi Evidence of in vitro differential secretion of 72 and 92 kDa type IV collagenases after selective exposure to lipopolysaccharide in human fetal membranes
    Guadalupe Garcia Lopez
    Direction of Research, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, Mexico
    Mol Hum Reprod 13:409-18. 2007
    ....
  9. ncbi Metzincin proteases and their inhibitors: foes or friends in nervous system physiology?
    Santiago Rivera
    Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, Unité Mixte de Recherche 6184, Centre National de la Recherche Scientifique, Universite de la Mediterranee, 13344 Marseille, France
    J Neurosci 30:15337-57. 2010
    ..The present review provides a state of the art overview of the involvement of the metzincin/TIMP system in these processes and the prospects of new therapeutic strategies based on the control of metalloproteinase activity...
  10. ncbi MMP/TIMP imbalance in amniotic fluid during PROM: an indirect support for endogenous pathway to membrane rupture
    S J Fortunato
    Perinatal Research Center, Women s Health Research and Education Foundation, Nashville, TN, USA
    J Perinat Med 27:362-8. 1999
    ..This study examines the levels of the gelatinases and their natural inhibitors (tissue inhibitor of matrix metalloproteinases-TIMPs) in the amniotic fluid during PROM, preterm labor (PTL) and at term...
  11. ncbi Matrix metalloproteases and their inhibitors are produced by overlapping populations of activated astrocytes
    E M Muir
    Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK
    Brain Res Mol Brain Res 100:103-17. 2002
    ..Conversely the MMPs produced may not be adequate to promote migration of cells and axons within the glial scar...
  12. ncbi Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling
    Y Y Li
    1750 Biomedical Science Tower, Cardiovascular Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cardiovasc Res 46:214-24. 2000
    ..It is therefore suggested that the interplay of MMPs and their regulators is important in the development of the heart failure phenotype, and myocardial fibrosis in heart failure may be modified by modulating MMP activity...
  13. ncbi Matrix metalloproteinases and their tissue inhibitors in preterm perinatal complications
    Julia V Cockle
    Perinatal Research Group, Leeds, United Kingdom
    Reprod Sci 14:629-45. 2007
    ..MMPs are involved in the perinatal complications of prematurity and are potential targets for therapeutic intervention. Functional MMP genetic polymorphisms may assist in identifying patients at risk of complications...
  14. ncbi The activity of matrix metalloproteinases (MMPS) and tissue inhibitors of metalloproteinases (TIMPs) in mammary tumors of dogs and rats
    Kouji Kawai
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
    J Vet Med Sci 68:105-11. 2006
    ....
  15. ncbi Extracellular matrix components and regulators in the airway smooth muscle in asthma
    B B Araujo
    Dept of Pathology, Sao Paulo University Medical School, Avenida Dr Arnaldo, 455, 01246 903, Sao Paulo SP, Brazil
    Eur Respir J 32:61-9. 2008
    ....
  16. ncbi Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology
    T Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 44:2777-89. 2001
    ..To understand changes in gene expression levels that occur during osteoarthritic (OA) cartilage degeneration, using complementary DNA (cDNA)-array technology...
  17. ncbi Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2
    H Sato
    Department of Molecular Virology and Oncology, Kanazawa University, Japan
    FEBS Lett 393:101-4. 1996
    ..b>Tissue inhibitor of metalloproteinases (TIMP)-2 inhibited activation of progelatinase A by forming a stable complex with activated MT1-MMP...
  18. ncbi Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease
    Joseph D Raffetto
    Department of Surgery, VA Boston Healthcare System, West Roxbury, MA, United States
    Biochem Pharmacol 75:346-59. 2008
    ....
  19. ncbi Expression of matrix metalloproteinases in cyclosporin-treated gingival fibroblasts is regulated by transforming growth factor (TGF)-beta1 autocrine stimulation
    P Cotrim
    Discipline of Oral Pathology, University of Campinas Dental School, Piracicaba, Sao Paulo, Brazil
    J Periodontol 73:1313-22. 2002
    ....
  20. ncbi Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2
    G I Goldberg
    Division of Dermatology, Washington University School of Medicine, Saint Louis, MO 63110
    Proc Natl Acad Sci U S A 86:8207-11. 1989
    ..Both activity and activation of the complex can be completely inhibited by further addition of stoichiometric quantities of purified TIMP-2 or recombinant TIMP...
  21. ncbi Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development
    Andrea Page-McCaw
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Dev Cell 4:95-106. 2003
    ..Thus, MMPs are not required for Drosophila embryonic development, but, rather, for tissue remodeling...
  22. ncbi In vitro synthesis of the active tissue inhibitor of metalloproteinases encoded by a complementary DNA from virus-infected murine fibroblasts
    B Coulombe
    Institut du Cancer de Montreal, Quebec, Canada
    J Biol Chem 263:1439-43. 1988
    ..described the characterization and expression of a murine gene highly homologous to the human tissue inhibitor of metalloproteinases/erythroid potentiating activity (TIMP/EPA) gene...
  23. ncbi Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas
    S J Urbanski
    Department of Pathology, University of Calgary, Alberta, Canada
    Br J Cancer 66:1188-94. 1992
    ..The possible prognostic significance of the expression of the latter two enzymes by carcinomas remains to be established...
  24. ncbi Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle
    J E Fata
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Biol Reprod 65:680-8. 2001
    ..We propose that the cyclical turnover of epithelial cells within the adult mammary tissue is a sum of spatial and functional coordination of hormonal and matrix regulatory factors...
  25. ncbi Tissue inhibitor of metalloproteinases-4 (TIMP-4) gene expression is increased in human osteoarthritic femoral head cartilage
    Wensheng Huang
    Departments of Medicine, Research Center and Notre Dame Hospital of the Centre hospitalier de l université de Montréal CHUM, Montreal, Quebec, Canada H2L 4M1
    J Cell Biochem 85:295-303. 2002
    b>Tissue inhibitor of metalloproteinases-4 (TIMP-4), the newest member of the TIMP family, blocks the activities of several matrix metalloproteinases (MMPs) implicated in the arthritic cartilage erosion...
  26. ncbi Transcription factor early growth response 1 activity up-regulates expression of tissue inhibitor of metalloproteinases 1 in human synovial fibroblasts
    Wilhelm K Aicher
    University Hospital Tubingen, Tubingen, Germany
    Arthritis Rheum 48:348-59. 2003
    To investigate the regulatory potential of early growth response 1 (Egr-1) on tissue inhibitor of metalloproteinases 1 (TIMP-1) expression in synovial fibroblasts.
  27. ncbi Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines
    Beatrice E Bachmeier
    Department Clinical Chemistry and Clinical Biochemistry, Hospital of Surgery, Ludwig Maximilians University, Nussbaumstr 20, D 80336 MUnchen, Germany
    Exp Cell Res 305:83-98. 2005
    ..Our data provide clear evidence that cell density regulates major MMPs and TIMPs which are controlled by AP-1 activity so that ultimately a major regulation pathway for the control of the invasive potential of tumor cells is presented...
  28. ncbi Localization of matrix metalloproteinases, (MMPs) their tissue inhibitors, and vascular endothelial growth factor (VEGF) in growth plates of children and adolescents indicates a role for MMPs in human postnatal growth and skeletal maturation
    G Haeusler
    Pediatric Department, Medical University of Vienna, Austria
    Calcif Tissue Int 76:326-35. 2005
    ....
  29. ncbi Expression of genes encoding matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in normal and diseased canine mitral valves
    H Aupperle
    Institut für Veterinär Pathologie, Veterinärmedizinische Fakultät, Universitat Leipzig, An den Tierkliniken 33, 04103 Leipzig
    J Comp Pathol 140:271-7. 2009
    ..MMPs and TIMPs are therefore likely to be involved in extracellular matrix metabolism in normal canine MVs and there are significant alterations in the expression of genes encoding these molecules during CVD...
  30. ncbi Matrix metalloproteinases (MMPs) in health and disease: an overview
    Charles J Malemud
    Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Front Biosci 11:1696-701. 2006
    ..MMP activity is regulated by a group of endogenous proteins, called, tissue inhibitor of metalloproteinases (TIMPs) that bind to active and alternative sites of the activated MMP...
  31. ncbi Regulation of matrix metalloproteinases: an overview
    Sajal Chakraborti
    Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India
    Mol Cell Biochem 253:269-85. 2003
    ....
  32. ncbi How matrix metalloproteinases regulate cell behavior
    M D Sternlicht
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Annu Rev Cell Dev Biol 17:463-516. 2001
    ..Our knowledge in the field of MMP biology is rapidly expanding, yet we still do not fully understand how these enzymes regulate most processes of development, homeostasis, and disease...
  33. ncbi Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers
    Stephanie Curran
    Department of Pathology, University of Aberdeen, Aberdeen, United Kingdom
    Clin Cancer Res 10:8229-34. 2004
    ..Therefore, to understand their role in tumor invasion, it is necessary to evaluate them collectively...
  34. ncbi Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis
    Carine Strup-Perrot
    , , 94805 Villejuif, France
    Am J Physiol Gastrointest Liver Physiol 287:G875-85. 2004
    ..This demonstrates that established fibrotic tissue is not scarred fixed tissue but is subjected to a dynamic remodeling process...
  35. ncbi The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis
    Takeshi Itoh
    Discovery Research Laboratories, Shionogi and Co, Ltd, Toyonaka City, Osaka, Japan
    J Immunol 169:2643-7. 2002
    ..These results indicated a suppressive role of MMP-2 and a pivotal role of MMP-9 in the development of inflammatory joint disease...
  36. ncbi MMP-TIMP interaction depends on residue 2 in TIMP-4
    B Stratmann
    University of Bielefeld, Faculty of Chemistry, Biochemistry I, , D-33615, Bielefeld, Germany
    FEBS Lett 507:285-7. 2001
    ..The effects of different substitutions of residue 2 (Ser(2)) in the inhibitory domain of TIMP-4 were determined by kinetic measurements. Size, charge and polarity of residue 2 in the TIMP structure are key factors in MMP inhibition...
  37. ncbi Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets
    Anna Radomski
    Department of Pharmacology, University of Alberta, 9 50 Medical Sciences Building, Edmonton, Ontario, Canada T6G 2H7
    Br J Pharmacol 137:1330-8. 2002
    ..11. Human rTIMP-4 exerted a biphasic effect on HT-1080 cells-induced aggregation. 12. Thus, TIMP-4 is the major intraplatelet MMP inhibitor and it is involved in regulation of platelet aggregation and recruitment...
  38. ncbi CpG island methylation and expression of tumour-associated genes in lung carcinoma
    Reinhard Dammann
    AWG Tumour Genetics of the Medical Faculty, Martin Luther University, Halle Wittenberg, 06097 Halle Saale, Germany
    Eur J Cancer 41:1223-36. 2005
    ..02), and exposure to asbestos (P=0.017) or squamous cell carcinoma (P=0.011), respectively. These results have identified genes whose aberrant promoter methylation could play a crucial role in the malignancy of lung carcinoma...
  39. ncbi mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas
    T Hagemann
    Department of Haematology Oncology, Georg August University Robert Koch Str 40, D 37075, Gottingen, Germany
    Eur J Cancer 37:1839-46. 2001
    ....
  40. ncbi The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation
    M D Tortorella
    DuPont Pharmaceuticals Company, Wilmington, DE 19880 0400, USA
    Osteoarthritis Cartilage 9:539-52. 2001
    ..Two cartilage aggrecanases have been identified, aggrecanase-1 (ADAM-TS4) and aggrecanase-2 (ADAM-TS5) and both enzymes have been shown very efficiently to cleave soluble aggrecan at the Glu(373)-Ala(374) site...
  41. ncbi Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases
    Wolfram Bode
    , Am Klopferspitz 18a, D-82152 Martinsried, Germany
    Biol Chem 384:863-72. 2003
    ..This review will outline our current structural knowledge of the MMPs and the TIMPs...
  42. ncbi In situ gene expression and localization of metalloproteinases MMP1, MMP2, MMP3, MMP9, and their inhibitors TIMP1 and TIMP2 in human renal cell carcinoma
    Venugopal Bhuvarahamurthy
    Department of Urology, University Hospital Charit, CCM, Humboldt University, Berlin, Germany
    Oncol Rep 15:1379-84. 2006
    ..Due to the small sample size further investigations need to be done to prove a statistical significant correlation between the MMP/TIMP expression and clinicopathological parameters...
  43. ncbi Electroporative alpha-MSH gene transfer attenuates thioacetamide-induced murine hepatic fibrosis by MMP and TIMP modulation
    C-H Wang
    Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Gene Ther 13:1000-9. 2006
    ..Its collagenolytic effect might be attributed to MMP and TIMP modulation. Hence, alpha-MSH gene therapy may be an effective therapeutic modality against liver fibrosis with potential clinical use...
  44. ncbi Analysis of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human ciliary body after latanoprost
    Dong-Jin Oh
    Laboratory for Molecular Ophthalmology, Wills Eye Hospital, Philadelphia, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 47:953-63. 2006
    ..TIMP-3 is upregulated and may compensate for the increase in MMPs. These coordinated changes could be expected to mediate the latanoprost-induced alteration of ECM in the ciliary body...
  45. ncbi Cirrhosis: new research provides a basis for rational and targeted treatments
    John P Iredale
    Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton SO16 6YD
    BMJ 327:143-7. 2003
  46. ncbi Complex roles of tissue inhibitors of metalloproteinases in cancer
    Yangfu Jiang
    Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus, Albert Einstein College of Medicine, New Hyde Park, New York, NY 11040, USA
    Oncogene 21:2245-52. 2002
    ..Elevated TIMP levels are reported in association with cancer progression and identified as poor prognostic indicators in several human tumor types. Herein, we review the complex roles of TIMPs in cancer growth and metastasis...
  47. ncbi Expression profiling of metalloproteinases and their inhibitors in cartilage
    Lara Kevorkian
    University of East Anglia, Norwich, UK
    Arthritis Rheum 50:131-41. 2004
    To profile the expression of all known members of the matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal cartilage and cartilage from patients with osteoarthritis (OA).
  48. ncbi Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and endometrial cancer
    Renuka Tunuguntla
    Department of Obstetrics Gynecology, University of Florida, Gainesville, FL 32610, USA
    Gynecol Oncol 89:453-9. 2003
    ....
  49. ncbi Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26
    R Pilka
    Department of Obstetrics and Gynaecology, University Hospital, S 221 85 Lund, Sweden
    Mol Hum Reprod 10:641-50. 2004
    ..Similarities in the cyclic patterns of TIMP-4 mRNA and MMP-26 mRNA, together with the fact that TIMP-4 is a potent inhibitor of MMP-26, suggest a functional relationship, and furthermore a role in human implantation...
  50. ncbi Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3
    Jian Zhang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, P R China
    Mol Hum Reprod 8:659-66. 2002
    ....
  51. ncbi Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development
    C V Hojilla
    Ontario Cancer Institute, University Health Network, Toronto, Canada
    Br J Cancer 89:1817-21. 2003
    ..The extracellular nature of the metalloproteinase axis situates it as a master regulator of cell fate...
  52. ncbi Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pathol 202:395-402. 2004
    ..0003). Thus, high tumour levels of the matrix metalloproteinases inhibitor and pro-apoptotic factor TIMP-3 are associated with successful tamoxifen treatment of patients with breast cancer...
  53. ncbi Novel functions of TIMPs in cell signaling
    Rosemarie Chirco
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA
    Cancer Metastasis Rev 25:99-113. 2006
    ....
  54. ncbi MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition
    H Li
    Department of Cardiovascular Therapeutics, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Cardiovasc Res 46:298-306. 2000
    ....
  55. ncbi Molecular cloning of an ovine ovarian tissue inhibitor of metalloproteinases: ontogeny of messenger ribonucleic acid expression and in situ localization within preovulatory follicles and luteal tissue
    G W Smith
    Department of Animal Science, University of Missouri, Columbia 65211
    Endocrinology 134:344-52. 1994
    Secretion of a tissue inhibitor of metalloproteinases (TIMP-1) is initiated by ovine preovulatory follicles after the gonadotropin surge. In addition, TIMP-1 is a major secretory product of ovine corpora lutea...
  56. ncbi Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4
    J Greene
    Human Genome Sciences, Inc, Rockville, Maryland 20850 3338, USA aecom yu edu
    J Biol Chem 271:30375-80. 1996
    ..This unique expression pattern suggests that TIMP-4 may function in a tissue-specific fashion in extracellular matrix homeostasis...
  57. ncbi Analysis of TIMP expression and activity
    Linda Troeberg
    Methods Mol Med 135:251-67. 2007
    ....
  58. ncbi Tissue inhibitors of metalloproteinases: evolution, structure and function
    K Brew
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL 33101, USA
    Biochim Biophys Acta 1477:267-83. 2000
    ....
  59. ncbi Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse
    L O Gonzalez
    Unidad de Investigacion, Hospital de Jove, Gijon, Spain
    Br J Cancer 97:957-63. 2007
    ..Therefore, this finding suggests that these host inflammatory cells could be a possible target for inhibition of metastasis...
  60. ncbi Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas
    J L Jones
    Breast Cancer Research Unit, Department of Pathology, University of Leicester, Glenfield General Hospital, Groby Road, Leicester LE3 9QP, U K
    J Pathol 189:161-8. 1999
    ..The association of MMP-9 with the infiltrating lobular phenotype may reveal novel mechanisms of control for this metalloproteinase...
  61. ncbi Activation and silencing of matrix metalloproteinases
    Xiaoyun Fu
    Department of Medicine, University of Washington, Seattle, WA, USA
    Semin Cell Dev Biol 19:2-13. 2008
    ..interactions, oxidative modification, pericellular compartmentalization, interaction with tissue inhibitor of metalloproteinases (TIMPs), endocytosis, and more have been proposed to control the activation and inactivation of ..
  62. ncbi Insights into MMP-TIMP interactions
    W Bode
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Ann N Y Acad Sci 878:73-91. 1999
    ..Very recently, structural information also became available for some TIMP structures and MMP-TIMP complexes, and these new data elucidated important structural features that govern the enzyme-inhibitor interaction...
  63. ncbi Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure
    V S Mujumdar
    Department of Physiology and Biophysics, and Center of Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    J Hypertens 17:261-70. 1999
    ..Collagen is induced during the transition from compensatory hypertrophy to heart failure. We hypothesized that cardiac stiffness during decompensatory hypertrophy is partly due to a decreased elastin:collagen ratio...
  64. ncbi Effects of hyperinsulinemia on hepatic metalloproteinases and their tissue inhibitors
    Guenther Boden
    Temple University Hospital, Philadelphia, PA 19140, USA
    Am J Physiol Endocrinol Metab 295:E692-7. 2008
    ..We conclude that hyperinsulinemia, whether or not associated with insulin resistance, shifts the MMP/TIMP balance toward reduction of extracellular matrix degradation and thus may promote the development of hepatic fibrosis...
  65. ncbi Balance between matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in the cervical mucus plug estimated by determination of free non-complexed TIMP
    Naja Becher
    Department of Obstetrics and Gynecology, Arhus University Hospital, Skejby, Aarhus N, Denmark
    Reprod Biol Endocrinol 6:45. 2008
    ..This indicates a potential to degrade extracellular matrix components depending on the balance between free non-complexed inhibitors and active enzymes...
  66. ncbi Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes
    J M Derry
    MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, United Kingdom
    Genomics 12:632-8. 1992
    Genes encoding the neuron-specific phosphoprotein synapsin I (SYN1), the glycoprotein tissue inhibitor of metalloproteinases (TIMP), the proto-oncogene A-raf-1 (ARAF1), and properdin (PFC), a positive regulator of the alternative pathway ..
  67. ncbi MicroRNAs are involved in homocysteine-induced cardiac remodeling
    Paras K Mishra
    Department of Physiology and Biophysics, University of Louisville, School of Medicine, A 1215, 500 South Preston Street, Louisville, KY, 40202, USA
    Cell Biochem Biophys 55:153-62. 2009
    ..The miRNA microarray assay revealed differential expression of 11 miRNAs and among them miR-188 show dramatic downregulation. These findings suggest that dicer and miRNAs especially miR-188 are involved in Hcy-induced cardiac remodeling...
  68. ncbi Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression
    C Ramos
    Instituto Nacional de Enfermedades Respiratorias, Mexico DF, Mexico
    Am J Respir Cell Mol Biol 24:591-8. 2001
    ..These results suggest that fibroblasts from IPF exhibit a profibrotic secretory phenotype, with lower growth rate and increased spontaneous apoptosis...
  69. ncbi Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)
    G Hashimoto
    Department of Pathology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-0016, Japan
    FEBS Lett 494:192-5. 2001
    ..These results suggest that TIMP-3 is a potent inhibitor against the aggrecanase activity of ADAMTS4 in vivo...
  70. ncbi Expression of matrix metalloproteinases and their endogenous tissue inhibitors in skin lesions from patients with tuberous sclerosis
    Eleni Papakonstantinou
    Department of Pharmacology, Aristotle University of Thessaloniki, Greece
    J Am Acad Dermatol 51:526-33. 2004
    ....
  71. ncbi [Comparison of doxycycline, losartan, and their combination on the expression of matrix metalloproteinase, tissue inhibitor of matrix metalloproteinase, and collagen remodeling in the noninfarcted myocardium after acute myocardial infarction in rats]
    Pei Zhang
    Department of Coronary Heart Disease, Fuwai Hospital, CAMS and PUMC, Beijing 100037, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:53-61. 2005
    ....
  72. ncbi Matrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury
    Kunyu Yang
    Department of Radiotherapy and Radiooncology, Saarland University, Homburg Saar, Germany
    Int J Radiat Biol 83:665-76. 2007
    ..On this background, we investigated the effect of irradiation on the MMP/TIMP system in the lung tissue of normal and transgenic TGF-beta1 mice, in which TGF-beta1 is overexpressed in the liver resulting in high TGF-beta1 plasma levels...
  73. ncbi [Matrix metalloproteinases and atherosclerosis. Therapeutic aspects]
    J L Beaudeux
    Service de Biochimie C, Group Hospitalier Pitie Salpetriere, AP HP, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13
    Ann Biol Clin (Paris) 61:147-58. 2003
    ..This review highlights the structures of MMPs and their physiological inhibitors, the Tissue Inhibitors of MMPs (TIMPs), and describes the current developments in pharmacological MMP inhibition...
  74. ncbi [Immunohistochemical localization of matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in tuberculous pleuritis]
    G Hoheisel
    Abt Pneumologie, Med Klinik und Poliklinik I
    Pneumologie 58:305-8. 2004
    ..In conclusion, the immunohistochemical demonstration of MMP and TIMP in pleural cells and tissue structures indicates their local involvement in fibrosing reactions in TB-pleuritis...
  75. ncbi Natural aging, expression of fibrosis-related genes and collagen deposition in rat lung
    Carmen Calabresi
    Department of Internal Medicine, Ospedale Maggiore IRCCS, University of Milan, Italy
    Exp Gerontol 42:1003-11. 2007
    ....
  76. ncbi Effects of hepatocyte growth factor on the expression of matrix metalloproteinases and their tissue inhibitors during the endometrial cancer invasion in a three-dimensional coculture
    Y-H Park
    Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea
    Int J Gynecol Cancer 13:53-60. 2003
    ....
  77. ncbi Expression of matrix metalloproiteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in hepatocellular carcinoma tissue, compared with the surrounding non-tumor tissue
    Yoshiko Matsunaga
    Second Department of Internal Medicine, Tottori University School of Medicine, Yonago 683 8504, Japan
    Res Commun Mol Pathol Pharmacol 115:143-50. 2004
    ..random, and we immunohistologically examined the expression of MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, tissue inhibitor of metalloproteinases (TIMP)-1, TIMP-2, in cancerous and non-cancerous areas using avidin-biotin-peroxidase complex ..
  78. ncbi Dysregulation of the levels of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the early phase of cerebral ischemia
    Stefan Lorenzl
    Stroke 34:e37-8; author reply e37-8. 2003
  79. ncbi Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis
    Yoko Ishihara
    Department of Hygiene and Public Health I, School of Medicine, Tokyo Womens Medical University, Krawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Toxicol Lett 142:71-5. 2003
    ..This evidence indicated that up-regulation of P-selectin expression contributed to enhanced rate of tumor metastasis in lung with silicosis...
  80. ncbi Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:751-8. 2007
    ..Furthermore, differentiation of predictive ability by end point (MI vs CAD) has not been addressed. This study evaluated the association with MI of SNPs in genes encoding MMPs 1, 2, 3, and 9 and TIMPs 1, 2, and 3...
  81. ncbi Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes
    Clara L Sampieri
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Matrix Biol 27:128-38. 2008
    ..The definition of clusters of co-regulated genes among the two gene families will aid in bioinformatic dissection of control mechanisms...
  82. ncbi Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue
    Takehiko Kubota
    Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Periodontol 79:166-73. 2008
    ..The purpose of this study was to examine the effect of different expression levels of MMPs and their inhibitors, the tissue inhibitors of matrix metalloproteinases (TIMPs), in periodontitis...
  83. ncbi Relationships between matrix metalloproteinases and tissue inhibitor of metalloproteinases in the wall of abdominal aortic aneurysms
    K Nishimura
    Second Department of Surgery, Tottori University Faculty of Medicine, Tottori, Japan
    Int Angiol 22:229-38. 2003
    ..The precise relationship among MMPs and tissue inhibitor of metalloproteinases (TIMPs) is still unclear...
  84. ncbi Detection of matrix metalloproteinases (MMP), tissue inhibitor of metalloproteinase-2, urokinase and plasminogen activator inhibitor-1 within matrigel and growth factor-reduced matrigel basement membrane
    Karin M Gillette
    Center for Protease Research, North Dakota State University College of Pharmacy, Fargo, North Dakota, USA
    Tumori 89:421-5. 2003
    ..CONCLUSIONS: These data provide a useful reference for interpretation of in vitro Matrigel assays...
  85. ncbi Altered transcripts expression of matrix metalloproteinases and their tissue inhibitors in tenon capsule of patients with glaucoma
    Catherine J Liu
    Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Glaucoma 13:486-91. 2004
    ..To determine the transcripts expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in Tenon capsule of patients with primary glaucoma and non-glaucomatous patients who serve as the control...
  86. ncbi Expression of matrix metalloproteinases and their inhibitors in medulloblastomas and their prognostic relevance
    Ozlem Ozen
    , , Munich
    Clin Cancer Res 10:4746-53. 2004
    ..The expression of TIMPs and MMPs, however, does not determine prognosis independently of clinical parameters...
  87. ncbi Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy
    S X Bai
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Reproduction 129:103-13. 2005
    ..Meanwhile, the study provides a better understanding of the mechanisms involved in cellular events during human pregnancy, especially at the initiation stage of implantation...
  88. ncbi [Effects of doxycycline on the expression of matrix metalloproteinase and tissue inhibitor of MMP in myocardium after acute myocardial infarction: an animal experiment with rats]
    Pei Zhang
    Department of Coronary Heart Disease, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 84:1288-93. 2004
    ..CONCLUSION: Doxycycline suppresses the enhanced mRNA and protein expressions of MMP-8 and 13 and TIMP-1 and 2, and type I collagen deposition in the noninfarcted myocardium after AMI, but it has no effect on type III collagen deposition...
  89. ncbi [Role of matrix metalloproteinase-2,9 and their inhibitors in premature rupture of membranes]
    Hong-Lin Wang
    Department of Obstetrics and Gynecology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Zhonghua Fu Chan Ke Za Zhi 40:29-33. 2005
    ....
  90. ncbi Expression of extracellular matrix molecules, MMPs and TIMPs in alveolar bone, cementum and periodontal ligaments during rat tooth eruption
    Yuriko Maruya
    Division of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan
    J Electron Microsc (Tokyo) 52:593-604. 2003
    ..The remodelling of ECM in these periodontal tissues might be regulated through balance among the production of ECM molecules, the degradation of ECM by MMPs and the inhibition of MMPs by TIMPs during tooth eruption...
  91. ncbi [Significance of imbalance between matrix metalloproteinases and tissue type inhibitor of metalloproteinases in renal tubulointerstitial lesions of aging rats]
    Rong-Quan Chen
    Department of Nephrology, General Hospital of PLA, Kidney Center and Key Laboratory of PLA, Beijing 100853, China
    Zhonghua Yi Xue Za Zhi 84:937-42. 2004
    ..CONCLUSION: The abnormal expression of MMPs/TIMPs including higher expression of TIMPs and decreased proteolytic activity of MMPs induced by aging may be one of the factors aggravating the renal tubulointerstitial lesions of aging rats...
  92. ncbi Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer
    Marja Hilska
    Department of Surgery, Turku University Central Hospital, Turku, Finland
    Int J Cancer 121:714-23. 2007
    ..Different biologic behavior or different genetic development may explain the differences between colon and rectal cancers regarding the expression of MMP-2, TIMP-3 and TIMP-4...
  93. ncbi Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover
    P A Phillips
    Pancreatic Research Group, Department of Gastroenterology, Bankstown Lidcombe and Liverpool Hospitals, and University of New South Wales, Sydney, Australia
    Gut 52:275-82. 2003
    ..However, the role of these cells in ECM protein degradation has not been fully elucidated...
  94. ncbi Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat
    J T Peterson
    Department of Cardiovascular Therapeutics, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Cardiovasc Res 46:307-15. 2000
    ....
  95. ncbi Fibroblast extracellular matrix gene expression in response to keratinocyte-releasable stratifin
    Abdi Ghaffari
    Department of Surgery, BC Professional Firefighter's Burn and Wound Healing Research Lab, University of British Columbia, Vancouver, Canada
    J Cell Biochem 98:383-93. 2006
    ..Therefore, stratifin protein may prove to be a useful target for clinical intervention in controlling excessive wound healing in fibrotic conditions...
  96. ncbi Individual Timp deficiencies differentially impact pro-MMP-2 activation
    Jane L English
    Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 281:10337-46. 2006
    ..Thus, TIMP-3 provides an inherent regulation over the kinetics of pro-MMP-2 processing, serving at a level distinct from that of TIMP-2 and TIMP-4...
  97. ncbi Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma
    Zu hua Gao
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, AB, Canada
    Mod Pathol 19:533-40. 2006
    ..These data suggest that tissue expression of E-cadherin, certain MMPs, and tissue inhibitors of metalloproteinases could be useful markers to predict the progression and metastasis of hepatocellular carcinoma...
  98. ncbi Induction of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs correlates with outcome of acute experimental pseudomonal keratitis
    Kousuke Ikema
    Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Honjo, Kumamoto, Japan
    Exp Eye Res 83:1396-404. 2006
    ..Although TIMP-1 was expressed in later stages of infection, enhancement and activation of MMP-9 were much faster and stronger than those of TIMP-1, thereby facilitating tissue destruction leading to corneal ulceration...
  99. ncbi The imbalance between metalloproteinases and their tissue inhibitors is involved in the pathogenesis of dermatitis herpetiformis
    Agnieszka Zebrowska
    Department of Dermatology and Venereology, Medical University of Lodz, Poland
    Mediators Inflamm 2005:373-9. 2005
    ..Expression of TIMPs was moderate or weak in all examined biopsies. Our results allow us to conclude that imbalance between these enzymes takes an important role in the pathogenesis of DH...
  100. ncbi Temporospatial distribution of matrix metalloproteinase and tissue inhibitors of matrix metalloproteinases during murine secondary palate morphogenesis
    J Morris-Wiman
    Department of Orthodontics, College of Dentistry, University of Florida, Gainesville 32610 0444, USA
    Anat Embryol (Berl) 202:129-41. 2000
    ..These results provide support for the idea that temporospatially controlled interactions between MMPs and their substrates may be pivotal in modulating events in palatal morphogenesis...
  101. ncbi Expression pattern of matrix metalloproteinase and TIMP genes in fibroblasts derived from Ets-1 knock-out mice compared to wild-type mouse fibroblasts
    Jens Claus Hahne
    Institute of Pathology, University of Bonn, 53011 Bonn, Germany
    Int J Mol Med 18:153-9. 2006
    ....

Research Grants74

  1. METALLOPROTEASES IN CONNECTIVE TISSUE MATRIX BREAKDOWN
    Hideaki Nagase; Fiscal Year: 1993
    ..this will be approached by identification of the side chains involved in binding to tissue inhibitor of metalloproteinases 1 (TIMP-1) and in reaction with alpha2- macroglobulin by a competitive binding "label selection" ..
  2. Matrix Metalloproteinases and the Blood-Brain Barrier
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    ..Matrix metalloproteinase inhibitors will be studied that have the potential to be used to prevent the death of vulnerable cells in the white matter. ..
  3. Sertoli cell injury and mechanisms of testicular germ cell apoptosis
    John H Richburg; Fiscal Year: 2010
    ..It is anticipated that the mechanistic insights provided from this work will be useful for predicting and preventing human reproductive health risks to chemicals, such as the phthalates, found ubiquitously in the environment. ..
  4. ALPHA-2 MACROGLOBULIN RECEPTOR, RAP, AND PREECLAMPSIA
    Dudley Strickland; Fiscal Year: 1993
    ..determine if the alpha2MR mediates catabolism of metalloproteinase complexed to their inhibitor, tissue inhibitor of metalloproteinases (TIMP). The second specific alm is designed to explore the role of RAP in trophoblast invasion...
  5. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2006
    ..Understanding the molecular events in the BBB disruption by MMPs will provide a rational basis for drug design, and will lead to novel treatments in many important neurological diseases. ..
  6. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    Cindy Morris; Fiscal Year: 2009
    ..Defining how HCMV impairs EVT invasion is of major importance to the reproductive community and may provide additional therapeutic targets to maintain viable pregnancy. ..
  7. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    Cindy Morris; Fiscal Year: 2009
    ..Defining how HCMV impairs EVT invasion is of major importance to the reproductive community and may provide additional therapeutic targets to maintain viable pregnancy. ..
  8. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2006
    ..3). To determine whether overexpression of Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) in mouse lung exacerbates silica- induced lung injury. ..
  9. DNA CAPILLARY ELECTROPHORESIS PROTOCOLS AND PROCESSES
    Michael Morris; Fiscal Year: 2002
    ..Second, homocysteine in pathologically relevant concentrations induced the expression of tissue inhibitor of metalloproteinases-1 (TIMP- 1) and alpha1 (I) procollagen in a hepatic stellate cell line and collagen production in ..
  10. COLLAGENOLYSIS-DRIVEN MOLECULAR MOTORS IN CELL MIGRATION AND MATRIX REMODELING
    Gregory I Goldberg; Fiscal Year: 2010
    ..The goal of this proposal is to provide for a better understanding of the molecular mechanisms of spatially regulated peri-cellular proteolysis catalyzed by MMPs and its functional role in numerous normal and pathological conditions. ..
  11. COLLAGENOLYSIS-DRIVEN MOLECULAR MOTORS IN CELL MIGRATION AND MATRIX REMODELING
    Gregory Goldberg; Fiscal Year: 2009
    ..The goal of this proposal is to provide for a better understanding of the molecular mechanisms of spatially regulated peri-cellular proteolysis catalyzed by MMPs and its functional role in numerous normal and pathological conditions. ..
  12. ALTERED METHIONINE METABOLISM IN ALCOHOLIC LIVER INJURY
    Shelly Lu; Fiscal Year: 2005
    ..Second, homocysteine in pathologically relevant concentrations induced the expression of tissue inhibitor of metalloproteinases-4 (TIMP- 1) and a 1(I) procollagen in a hepatic stellate cell line and collagen production in ..
  13. Mechanisms of Reduced Fecundity in Endometriosis: A role for MMPs and TIMPs
    KATHY L TIMMS; Fiscal Year: 2010
    ..As it is known that TIMP-1 highly regulates MMPs critical for follicular development, ovulation and embryo development, we propose endometriotic TIMP-1 is blocking MMPs required for normal function and reducing fecundity. ..
  14. Endothelial Myocyte Matrix in Cardiac Remodeling
    SURESH TYAGI; Fiscal Year: 2009
    ....
  15. Endothelial Myocyte Matrix in Cardiac Remodeling
    SURESH TYAGI; Fiscal Year: 2009
    ....
  16. Endothelial Myocyte Matrix in Cardiac Remodeling
    Suresh C Tyagi; Fiscal Year: 2010
    ....
  17. Matrix Metalloproteinases and Spinal Cord Injury
    Linda J Noble; Fiscal Year: 2010
    ....
  18. Matrix Metalloproteinases in Hepatic Ischemia and Reperfusion Injury
    Ana J Coito; Fiscal Year: 2010
    ..relative contribution in normal and steatotic liver IRI;and (3) To dissect the mechanisms by which tissue inhibitor of metalloproteinases-1 affects IRI in normal and in steatotic livers...
  19. The Role of Leptin in Liver Fibrogenesis
    Frank Anania; Fiscal Year: 2009
    ..The project seeks to determine whether adiponectin can act as a protector from the harmful effects of leptin in liver fibrosis. ..
  20. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2010
    ..The project seeks to determine whether adiponectin can act as a protector from the harmful effects of leptin in liver fibrosis. ..
  21. The Role of Leptin in Liver Fibrogenesis
    Frank Anania; Fiscal Year: 2009
    ..The project seeks to determine whether adiponectin can act as a protector from the harmful effects of leptin in liver fibrosis. ..
  22. Mechanism of mutant TIMP-3 induced neovascularization
    Michael Tolentino; Fiscal Year: 2004
    ..Specific aim 3: To develop and test gene vectors expressing inhibitors of angiogenesis (angiostatin, endostatin, PEDF) and test their ability to inhibit subretinal neovascularization in the mutant transgenic mouse. ..
  23. Neuronal survival, HIV-1 and Astrocyte TIMP-1
    Anuja Ghorpade; Fiscal Year: 2010
    ..Our studies will provide a better understanding of the specific mechanistic contributions of activated astrocytes to HIV-1-neuropathogensis and neuroinflammation. ..