antiplasmin

Summary

Summary: A member of the serpin superfamily found in human plasma that inhibits the lysis of fibrin clots which are induced by plasminogen activator. It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. It is the principal plasmin inactivator in blood, rapidly forming a very stable complex with plasmin.

Top Publications

  1. ncbi Antiplasmin: the forgotten serpin?
    Paul B Coughlin
    Australian Centre for Blood Diseases, Monash University, Prahran
    FEBS J 272:4852-7. 2005
  2. ncbi On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin
    B Wiman
    J Biol Chem 254:9291-7. 1979
  3. ncbi Analysis of plasminogen activation by the plasmin-staphylokinase complex in plasma of alpha2-antiplasmin-deficient mice
    K Okada
    Department of Physiology, Kinki University School of Medicine, Osakasayama City, Osaka, Japan
    Blood Coagul Fibrinolysis 11:645-55. 2000
  4. ncbi Depletion of circulating alpha(2)-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization
    N Nagai
    Center for Molecular and Vascular Biology and Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Blood 97:3086-92. 2001
  5. ncbi Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of Yersinia pestis
    M Kukkonen
    Division of General Microbiology, Department of Biosciences, University of Helsinki, Finland
    Mol Microbiol 40:1097-111. 2001
  6. pmc The kidney is a major site of alpha(2)-antiplasmin production
    P A Menoud
    Department of Medicine, Division of Oncology, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    J Clin Invest 97:2478-84. 1996
  7. pmc Associations of factor VIIIc, D-dimer, and plasmin-antiplasmin with incident cardiovascular disease and all-cause mortality
    Aaron R Folsom
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Hematol 84:349-53. 2009
  8. ncbi Characterization and targeting of the murine alpha2-antiplasmin gene
    K Okada
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 78:1104-10. 1997
  9. ncbi Enhanced fibrinolytic potential in mice with combined homozygous deficiency of alpha2-antiplasmin and PAI-1
    M Dewerchin
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Thromb Haemost 86:640-6. 2001
  10. ncbi Activated thrombin-activatable fibrinolysis inhibitor reduces the ability of high molecular weight fibrin degradation products to protect plasmin from antiplasmin
    Mark Schneider
    Departments of Biochemistry and Medicine, Queen s University, Kingston Ontario K7L 3N6, Canada
    J Biol Chem 279:13340-5. 2004

Detail Information

Publications230 found, 100 shown here

  1. ncbi Antiplasmin: the forgotten serpin?
    Paul B Coughlin
    Australian Centre for Blood Diseases, Monash University, Prahran
    FEBS J 272:4852-7. 2005
    Much of the basic biochemistry of antiplasmin was described more than 20 years ago and yet it remains an enigmatic member of the serine protease inhibitor (serpin) family...
  2. ncbi On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin
    B Wiman
    J Biol Chem 254:9291-7. 1979
  3. ncbi Analysis of plasminogen activation by the plasmin-staphylokinase complex in plasma of alpha2-antiplasmin-deficient mice
    K Okada
    Department of Physiology, Kinki University School of Medicine, Osakasayama City, Osaka, Japan
    Blood Coagul Fibrinolysis 11:645-55. 2000
    ..plasminogen activator (PA) activity by forming a complex with plasmin; this PA activity is inhibited by alpha2-antiplasmin (alpha2-AP) in plasma...
  4. ncbi Depletion of circulating alpha(2)-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization
    N Nagai
    Center for Molecular and Vascular Biology and Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Blood 97:3086-92. 2001
    ..However, FII is smaller in mice lacking alpha(2)-antiplasmin (alpha(2)-AP), the physiologic inhibitor of plasmin, suggesting its depletion might reduce FII in the absence ..
  5. ncbi Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of Yersinia pestis
    M Kukkonen
    Division of General Microbiology, Department of Biosciences, University of Helsinki, Finland
    Mol Microbiol 40:1097-111. 2001
    ..recombinant Escherichia coli formed active plasmin in the presence of the major human plasmin inhibitor, alpha2-antiplasmin, and the bacteria were found to inactivate alpha2-antiplasmin...
  6. pmc The kidney is a major site of alpha(2)-antiplasmin production
    P A Menoud
    Department of Medicine, Division of Oncology, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    J Clin Invest 97:2478-84. 1996
    The serpin alpha2-antiplasmin (alpha2-AP) is the major circulating inhibitor of plasmin; it plays a determining role in the regulation of intravascular fibrinolysis, In addition to blood plasma, plasmin formation occurs in various organs ..
  7. pmc Associations of factor VIIIc, D-dimer, and plasmin-antiplasmin with incident cardiovascular disease and all-cause mortality
    Aaron R Folsom
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Hematol 84:349-53. 2009
    To examine the associations of three understudied hemostatic factors--D-dimer, factor VIII(c), and plasmin-antiplasmin (PAP) complex--with incident cardiovascular disease (CVD) and all cause mortality in the Multiethnic Study of ..
  8. ncbi Characterization and targeting of the murine alpha2-antiplasmin gene
    K Okada
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 78:1104-10. 1997
    Alpha2-Antiplasmin (alpha2-AP) is the main physiological plasmin inhibitor in mammalian plasma...
  9. ncbi Enhanced fibrinolytic potential in mice with combined homozygous deficiency of alpha2-antiplasmin and PAI-1
    M Dewerchin
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Thromb Haemost 86:640-6. 2001
    Alpha2-antiplasmin (alpha2-AP) and plasminogen activator inhibitor-1 (PAI-1) are the main physiological inhibitors of the plasminogen/plasmin system in mammalian plasma...
  10. ncbi Activated thrombin-activatable fibrinolysis inhibitor reduces the ability of high molecular weight fibrin degradation products to protect plasmin from antiplasmin
    Mark Schneider
    Departments of Biochemistry and Medicine, Queen s University, Kingston Ontario K7L 3N6, Canada
    J Biol Chem 279:13340-5. 2004
    ..In this study, the effect of TAFIa modification of a fibrin surface on the rate of plasmin inhibition by antiplasmin was studied using high molecular weight fibrin degradation products (HMw-FDPs) as a soluble model for intact ..
  11. ncbi Identification of amino acids in antiplasmin involved in its noncovalent 'lysine-binding-site'-dependent interaction with plasmin
    Haiyao Wang
    Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Eur J Biochem 270:2023-9. 2003
    The lysine-binding-site-mediated interaction between plasmin and antiplasmin is of great importance for the fast rate of this reaction. It also plays an important part in regulating the fibrinolytic enzyme system...
  12. ncbi Primary structure of human alpha 2-antiplasmin, a serine protease inhibitor (serpin)
    W E Holmes
    J Biol Chem 262:1659-64. 1987
    The plasma protein alpha 2-antiplasmin is the main physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots...
  13. ncbi Induction of catalytic activity of plasminogen by monoclonal antibody IV-Ic in the presence of divalent metal cations and alpha2-antiplasmin
    L I Sokolovskaya
    Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, 01030, Ukraine
    Biochemistry (Mosc) 71:627-33. 2006
    ..The effect of alpha(2)-antiplasmin on the induction of plasminogen catalytic activity by monoclonal antibody IV-Ic in range of concentrations from ..
  14. ncbi Inactivation of the serpin alpha(2)-antiplasmin by stromelysin-1
    H R Lijnen
    Center for Molecular and Vascular Biology, University of Louvain, Campus Gasthuisberg, O and N, Herestraat 49, B 3000, Leuven, Belgium
    Biochim Biophys Acta 1547:206-13. 2001
    ..the Met(374)-Ser(375) (P3-P2), Glu(416)-Leu(417) and Ser(432)-Leu(433) peptide bonds in human alpha(2)-antiplasmin (alpha(2)-AP), the main physiological plasmin inhibitor...
  15. ncbi X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin
    Ruby H P Law
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    Blood 111:2049-52. 2008
    The serpin alpha(2)-antiplasmin (SERPINF2) is the principal inhibitor of plasmin and inhibits fibrinolysis. Accordingly, alpha(2)-antiplasmin deficiency in humans results in uncontrolled fibrinolysis and a bleeding disorder...
  16. pmc alpha2-antiplasmin is associated with the progression of fibrosis
    Yosuke Kanno
    Department of Clinical Pathological Biochemistry, Doshisha Women s College of Liberal Arts, 97 1 Kodo, Kyo tanabe 610 0395 Kyoto, Japan
    Am J Pathol 176:238-45. 2010
    ..We previously reported that the absence of alpha2-antiplasmin (alpha2AP) attenuated the process of dermal fibrosis; however, the detailed mechanism of how alpha2AP affects ..
  17. ncbi Antiplasmin activity of natural occurring polyphenols
    Matteo Mozzicafreddo
    MCAB Department, University of Camerino, 62032, Camerino MC, Italy
    Biochim Biophys Acta 1784:995-1001. 2008
    ..Furthermore, a feasible mechanism of interaction was analyzed and discussed using a molecular modeling approach...
  18. ncbi Alpha2-antiplasmin is involved in the production of transforming growth factor beta1 and fibrosis
    Y Kanno
    Department of Clinical Pathological Biochemistry, Faculty of Pharmaceutical Science, D W C L A, Kyoto, Japan
    J Thromb Haemost 5:2266-73. 2007
    ..The fibrinolytic system is considered to play an important role in the degradation of extracellular matrices. However, the detailed mechanism of how this system affects fibrosis remains unclear...
  19. ncbi Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent
    Robbert Jan J H M Miserus
    Department of Radiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    JACC Cardiovasc Imaging 2:987-96. 2009
    We aimed to investigate whether early thrombus formation can be visualized with in vivo magnetic resonance imaging (MRI) by the use of a novel bimodal alpha(2)-antiplasmin-based contrast agent (CA).
  20. ncbi The fibrinolysis inhibitor alpha2-antiplasmin in the human cornea
    Aidee Ayala
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Curr Eye Res 30:1097-103. 2005
    To determine whether the cornea contains and expresses, at the gene level, the major plasmin inhibitor alpha2-antiplasmin.
  21. pmc Addition of a sequence from alpha2-antiplasmin transforms human serum albumin into a blood clot component that speeds clot lysis
    William P Sheffield
    Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    BMC Biotechnol 9:15. 2009
    The plasma protein alpha2-antiplasmin (alpha2AP) is cross-linked to fibrin in blood clots by the transglutaminase factor XIIIa, and in that location retards clot lysis...
  22. pmc Coagulation factors II, V, IX, X, XI, and XII, plasminogen, and alpha-2 antiplasmin and risk of coronary heart disease
    Kazumasa Yamagishi
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    J Atheroscler Thromb 17:402-9. 2010
    To examine whether plasma levels of coagulation factors II, V, IX, X, XI, and XII, plasminogen, and alpha-2 antiplasmin are associated with coronary heart disease (CHD) in a prospective case-cohort study.
  23. ncbi Plasma levels of plasmin-antiplasmin-complexes are predictive for small abdominal aortic aneurysms expanding to operation-recommendable sizes
    J S Lindholt
    Department of Vascular Surgery, Hospital of Viborg, Denmark
    J Vasc Surg 34:611-5. 2001
    ..A random sample of 70 of the 112 cases had P-plasmin-antiplasmin-complexes (PAPs), P-plasminogen, and S-elastin-peptides (SEPs)...
  24. ncbi Molecular cloning and functional expression of rabbit alpha2-antiplasmin
    Brian N Jobse
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Blood Coagul Fibrinolysis 17:283-91. 2006
    ..Our aims were: to determine the nucleotide sequence of a full-length rabbit liver alpha(2)-antiplasmin (alpha(2)AP) cDNA; compare it with its human, murine, and bovine counterparts; and express it in functional ..
  25. ncbi Lack of alpha2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction
    Hiroyuki Matsuno
    Departments of Pharmacology and Critical Care Medicine and the First Department of Pathology, Gifu University School of Medicine, Gifu, Japan
    Blood 100:2487-93. 2002
    ..due to an experimental acute myocardial infarction (AMI) was markedly increased in mice deficient in alpha2-antiplasmin (alpha2-AP(-/-) mice) but not in mice deficient in other components acting in fibrinolysis (tissue-type PA, ..
  26. ncbi Characterization of wild-type and mutant alpha2-antiplasmins: fibrinolysis enhancement by reactive site mutant
    K N Lee
    William K Warren Medical Research Institute and the Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Blood 94:164-71. 1999
    During human blood clotting, alpha2-antiplasmin (alpha2AP) becomes covalently linked to fibrin when activated blood clotting factor XIII (FXIIIa) catalyzes the formation of an isopeptide bond between glutamine at position two in alpha2AP ..
  27. ncbi Characterizing the specificity of activated Factor XIII for glutamine-containing substrate peptides
    David B Cleary
    Department of Chemistry, University of Louisville, Louisville, KY 40292, USA
    Biochim Biophys Acta 1764:1207-17. 2006
    ..source of FXIIIa substrate specificity, Q-containing substrates based on beta-casein, K9-peptide, and alpha(2)-antiplasmin were characterized...
  28. ncbi Cross-linking of wild-type and mutant alpha 2-antiplasmins to fibrin by activated factor XIII and by a tissue transglutaminase
    K N Lee
    William K Warren Medical Research Institute and the Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Biol Chem 275:37382-9. 2000
    Human alpha(2)-antiplasmin (alpha(2)AP), the main inhibitor of plasmin-mediated fibrinolysis, is a substrate for plasma transglutaminase, also termed activated factor XIII (FXIIIa)...
  29. ncbi Haemostatic changes; plasma levels of alpha2-antiplasmin-plasmin complex and thrombin-antithrombin III complex in female breast cancer
    O Ozyilkan
    Bayindir Tip Merkezi, Medical Center, Department of Internal Medicine, Ankara, Turkey
    Tumori 84:364-7. 1998
    ..We investigated the fibrinolytic system marker alpha2-antiplasmin-plasmin complex (APP) and clotting system marker thrombin-antithrombin III complex (TAT) in patients with ..
  30. ncbi Evidence that alpha2-antiplasmin becomes covalently ligated to plasma fibrinogen in the circulation: a new role for plasma factor XIII in fibrinolysis regulation
    M W Mosesson
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
    J Thromb Haemost 6:1565-70. 2008
    Plasma alpha2-antiplasmin (alpha2AP) is a rapid and effective inhibitor of the fibrinolytic enzyme plasmin. Congenital alpha2AP deficiency results in a severe hemorrhagic disorder due to accelerated fibrinolysis...
  31. ncbi Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate
    I Y Sazonova
    Medical College of Georgia, Augusta, GA, USA
    J Thromb Haemost 5:2087-94. 2007
    alpha(2)-Antiplasmin (alpha(2)-AP) is the fast serpin inhibitor of plasmin and appears to limit the success of treatment for thrombosis...
  32. ncbi Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites
    J Potempa
    Institute of Molecular Biology, Jagiellonian University, Cracow, Poland
    Science 241:699-700. 1988
    Although the proteinase inhibitor alpha-2-antiplasmin (alpha 2AP) is known to control the activity of plasmin through rapid formation of stable complexes, it also efficiently inactivates chymotrypsin...
  33. ncbi The presence and release of alpha 2-antiplasmin from human platelets
    E F Plow
    Blood 58:1069-74. 1981
    An antigen immunochemically indistinguishable from plasma alpha 2-antiplasmin, the primary plasmin inhibitor, was detected in human platelets...
  34. ncbi Why alpha-antiplasmin must be converted to a derivative form for optimal function
    K N Lee
    William K Warren Medical Research Center and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    J Thromb Haemost 5:2095-104. 2007
    Human alpha(2)-antiplasmin (alpha(2)AP), the primary inhibitor of fibrinolysis, is secreted from the liver into plasma as a 464-residue protein with Met as the N-terminus...
  35. ncbi Lack of alpha2-antiplasmin improves cutaneous wound healing via over-released vascular endothelial growth factor-induced angiogenesis in wound lesions
    Y Kanno
    Department of Clinical Pathological Biochemistry, Faculty of Pharmaceutical Science, DWCLA, Kyoto, Japan
    J Thromb Haemost 4:1602-10. 2006
    ....
  36. ncbi Increased plasmin-alpha2-antiplasmin levels indicate activation of the fibrinolytic system in systemic amyloidoses
    B Bouma
    Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Thromb Haemost 5:1139-42. 2007
  37. ncbi A study of the protection of plasmin from antiplasmin inhibition within an intact fibrin clot during the course of clot lysis
    Mark Schneider
    Departments of Biochemistry and Medicine, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 279:13333-9. 2004
    Previous work using soluble fibrin surrogates or very dilute fibrin indicate that inhibition of plasmin by antiplasmin is attenuated by fibrin surrogates; however, this phenomenon has not been quantified within intact fibrin clots...
  38. ncbi TAFIa, PAI-1 and alpha-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots
    N J Mutch
    Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    J Thromb Haemost 5:812-7. 2007
    PAI-1 and alpha(2)-antiplasmin (alpha(2)AP) are the principal direct inhibitors of fibrinolytic proteases...
  39. ncbi A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion
    Kyung N Lee
    Department of Medicine, University of Oklahoma Sciences Center, Oklahoma City, OK 73190, USA
    Blood 103:3783-8. 2004
    Human alpha2-antiplasmin (alpha2AP), also known as alpha2-plasmin inhibitor, is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin...
  40. ncbi Primary intestinal and thoracic lymphangiectasia: a response to antiplasmin therapy
    Joanna E MacLean
    Division of Paediatric Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    Pediatrics 109:1177-80. 2002
    ..However, she had a clinical response to antiplasmin therapy, trans-4-aminothylcyclohexamine carboxylic acid (tranexamic acid) in terms of serum albumin and ..
  41. ncbi Induction of alpha2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion
    Yasutaka Hayashido
    Department of Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8553, Japan
    Oncol Rep 17:417-23. 2007
    ..To examine the effect of downregulation of the plasminogen activator/plasmin system by alpha2-antiplasmin (alpha2-AP) on cell-cell adhesion mediated by E-cadherin in oral SCC cells, the oral SCC cell line SCCKN was ..
  42. ncbi Alpha 2-antiplasmin Enschede: alanine insertion and abolition of plasmin inhibitory activity
    W E Holmes
    Center for Thrombosis and Vascular Research, University of Leuven, Belgium
    Science 238:209-11. 1987
    An abnormal alpha 2-antiplasmin that is associated with a serious bleeding tendency has been found in a Dutch family and is referred to as alpha 2-antiplasmin Enschede...
  43. ncbi Regular alcohol intake and fibrinolysis
    P M van Golde
    Meander Medical Centre, Department of Internal Medicine, Amersfoort, The Netherlands
    Neth J Med 60:285-8. 2002
    ..The question whether the alcohol-induced plasma increase of plasminogen activator inhibitor (PAI-1) may originate from thrombocytes was also addressed...
  44. ncbi Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms
    X Houard
    INSERM U698, Cardiovascular Haematology, Bioengineering and Remodelling, Bichat Claude Bernard Hospital, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    J Pathol 212:20-8. 2007
    ..for plasminogen activators (PAs), plasminogen activator inhibitor-1 (PAI-1), free-plasmin, plasmin alpha(2)-antiplasmin complexes (PAPs) and D-dimers release...
  45. ncbi The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome
    Catharina Suharti
    Department of Medicine, Faculty of Medicine, Diponegoro University and Dr Kariadi Hospital, Semarang, Indonesia
    Thromb Haemost 87:42-6. 2002
    ..03) and fibrinolysis (PAPc; p = 0.002). Our data are in line with studies in bacterial sepsis. In severe dengue virus infection the same cytokines are involved in the onset and regulation of hemostasis...
  46. ncbi Effects of a protease inhibitor, ulinastatin, on coagulation and fibrinolysis in abdominal surgery
    Tomoki Nishiyama
    Department of Anesthesiology, The University of Tokyo, Tokyo, Japan
    J Anesth 20:179-82. 2006
    ..The purpose of the present study was to investigate the effects of ulinastatin, a protease inhibitor, on coagulation and fibrinolysis in abdominal surgery...
  47. ncbi [Inhibition of the process of Glu-plasminogen activation by tissue activator with fibrin, DDE-complex, and D-dimer using alpha-2-antiplasmin]
    T V Hrynenko
    Ukr Biokhim Zh 77:45-51. 2005
    The alpha-2-antiplasmin influence on the Glu-plasminogen activation by tissue activator both on fibrin and fibrin(ogen) fragments was investigated...
  48. ncbi Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers
    Toshiaki Iba
    Division Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine
    J Trauma 63:1093-8. 2007
    ..The purpose of this study is to assess the prognostic value of these markers in patients with SIRS-associated hypercoagulopathy...
  49. ncbi [Diagnostic value of hemostasis activation markers in acute deep vein thrombosis]
    Elzbieta Tajanko
    Klinika Hematologii Akademii Medycznej w Białymstoku
    Pol Arch Med Wewn 107:237-41. 2002
    ..markers, prothrombin activation fragment 1 + 2 (F1 + 2), thrombin-antithrombin complex (TAT), plasmin-alpha 2-antiplasmin complex (PAP) and D-dimer in patients with acute deep venous thrombosis (DVT)...
  50. ncbi Structural elements that govern the substrate specificity of the clot-dissolving enzyme plasmin
    Ryan B Turner
    Cardiovascular Biology Laboratory, Harvard School of Public Health and the Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 277:33068-74. 2002
    ..enhanced resistance (k(i) decreased up to two to three times) to inactivation of microplasmin by alpha(2)-antiplasmin. Microplasmin chimerization had minimal ( approximately 2 fold) effects on the catalytic efficiency for ..
  51. ncbi Fibrinolytic response to exercise in women using third-generation oral contraceptives
    Claus Weiss
    Department of Internal Medicine VII Sportsmedicine, University Hospital Heidelberg, Germany
    Blood Coagul Fibrinolysis 17:563-8. 2006
    ..release of tissue-type plasminogen activator led to enhanced plasmin formation with respect to plasmin-antiplasmin complexes, rising by (mean +/- standard error) 701 +/- 77 ng/ml (P < 0...
  52. ncbi Intraluminal thrombus enhances proteolysis in abdominal aortic aneurysms
    Tom W G Carrell
    Academic Department of Surgery, King s College London, St Thomas Hospital, London, United Kingdom
    Vascular 14:9-16. 2006
    ..and urokinase plasminogen activator (uPA) activity, plasminogen activator inhibitor 1 (PAI-1), and alpha2-antiplasmin (alpha2AP) antigen were measured in the AAA wall and juxtamural and luminal aspects of intraluminal thrombus in ..
  53. ncbi [Evaluation of selected parameters of blood coagulation and the fibrinolysis system in patients undergoing total hip replacement]
    Bozena Sokołowska
    Klinika Hematologii Akademii Medycznej w Lublinie
    Przegl Lek 59:502-8. 2002
    ..2) the application of the hemodilution procedure does not influence significantly the degree of coagulation and fibrinolysis disorders in the perioperative period...
  54. ncbi Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo
    Monica Suelves
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
    Blood 99:2835-44. 2002
    ..Finally, we found that inhibition of plasmin activity with alpha2-antiplasmin resulted in decreased myoblast fusion and differentiation in vitro...
  55. ncbi Effects of long-term erythropoietin therapy on fibrinolytic system in haemodialyzed patients
    Krystyna Pawlak
    Department of Nephrology and Clinical Transplantation, Medical University, 14 Zurawia St, 15 540 Bialystok, Poland
    Thromb Res 121:787-91. 2008
    ..Recombinant human erythropoietin (rHuEPO) is the cornerstone of anaemia therapy in uraemic patients however the effects of this hormone on fibrinolytic system are difficult to interpret...
  56. ncbi Changes in peritoneal coagulation and fibrinolysis after discontinuation of chronic peritoneal dialysis
    Sumiko Homma
    Division of Nephrology, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Perit Dial Int 22:178-83. 2002
    ..To study changes in peritoneal function after transfer from chronic peritoneal dialysis (CPD) to hemodialysis (HD), especially the effects on peritoneal coagulation, fibrinolytic markers, and mesothelium...
  57. ncbi Coagulation and inflammation in overt diabetic nephropathy: association with hyperhomocysteinemia
    Yoshimasa Aso
    Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, 2 1 50 Minami Koshigaya, Koshigaya, Saitama 343 8555, Japan
    Clin Chim Acta 348:139-45. 2004
    ..We investigated the relationships between diabetic nephropathy and coagulation, fibrinolysis, or inflammation in patients with Type 2 diabetes...
  58. ncbi Tissue plasminogen activator plasma levels as a potential diagnostic aid in acute pulmonary embolism
    Julio Flores
    Servicio de Neumologia, Hospital Universitario Principe de Asturias, Alcala de Henares, Madrid, Spain
    Arch Pathol Lab Med 127:310-5. 2003
    ..Pulmonary embolism (PE) is a potentially fatal and frequent complication of deep venous thrombosis, and the most reliable techniques for the diagnosis of PE are not universally available and have other limitations...
  59. pmc Novel distribution pattern of fibrinolytic components in rabbit tissues extract: a preliminary study
    Xing Guo Lu
    Department of Haematology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    J Zhejiang Univ Sci B 8:570-4. 2007
    ..The purpose of this work was to investigate the distribution pattern of fibrinolytic factors and their inhibitors in rabbit tissues...
  60. ncbi Effect of four oral contraceptives on hemostatic parameters
    I Wiegratz
    Center of Obstetrics and Gynecology, University Hospital of Frankfurt, Frankfurt am Main, Germany
    Contraception 70:97-106. 2004
    ..four OCs caused an increase in levels of fibrinogen, prothrombin fragment 1+2, D-dimer, plasminogen, plasmin-antiplasmin complex and an increase in protein C activity, a decrease in antithrombin activity, tissue-plasminogen ..
  61. ncbi Genetic and environmental influences on the fibrinolytic system: a twin study
    Dirk Peetz
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Mainz, Germany
    Thromb Haemost 92:344-51. 2004
    ..43 for tissue plasminogen activator. No significant genetic influence was observed for alpha2-antiplasmin-plasmin-complex and D-dimer. Heritability explained by single gene polymorphisms was 25...
  62. ncbi Coagulation and fibrinolytic profiles and appropriate use of heparin after living-donor liver transplantation
    Junichi Kaneko
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    Clin Transplant 19:804-9. 2005
    ..High hemorrhage complications in our series indicate that the lower target ACT range may be preferable in the second post-operative week...
  63. ncbi Haemostatic activation in post-menopausal women taking low-dose hormone therapy: less effect with transdermal administration?
    Jeanette F Brosnan
    Coagulation Research Laboratory, Department of Obstetrics and Gynaecology, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Thromb Haemost 97:558-65. 2007
    ..Transdermal HT has a less marked effect on coagulation than an equivalent oral preparation. Randomised trials are required to investigate whether this translates into less risk of cardiovascular and thromboembolic disease...
  64. ncbi The influence of age on in vitro plasmin generation in the presence of fibrin monomer
    Nagina Parmar
    Pediatric Thrombosis and Hemostasis Program, The Hospital for Sick Children, Toronto, Canada
    Acta Haematol 115:141-51. 2006
    ..The present study was undertaken to explore the effect of physiological, age-dependent factors of the fibrinolytic system during childhood on the capacity to generate plasmin...
  65. ncbi The kinetics of plasmin inhibition by aprotinin in vivo
    Hyoung Min Kang
    Department of Laboratory Medicine, Box 357110, University of Washington, Seattle, WA 98195 7110, USA
    Thromb Res 115:327-40. 2005
    ..bypass (CPB), the in vivo rates of tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1) secretion, plasmin generation, fibrin degradation, and plasmin inhibition by aprotinin versus antiplasmin.
  66. ncbi Hydroxyethyl starch enhances fibrinolysis in human plasma by diminishing alpha2-antiplasmin-plasmin interactions
    Vance G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    Blood Coagul Fibrinolysis 18:647-56. 2007
    ..Normal plasma or plasmas deficient in factor XIII, thrombin activatable fibrinolysis inhibitor or alpha2-antiplasmin were either not diluted or were diluted 20% with 0...
  67. ncbi Laboratory evidence of hyperfibrinolysis in association with low plasminogen activator inhibitor type 1 activity
    Anna Agren
    Department of Hematology, Coagulation Unit, Karolinska University Hospital, Stockholm, Sweden
    Blood Coagul Fibrinolysis 18:657-60. 2007
    ..PAI-1 activity, plasmin-antiplasmin complex (PAP) and D-dimer were analyzed in plasma samples from 424 consecutive patients referred to the ..
  68. ncbi [Degradation of streptokinase and the catalytic properties of the plasmin-streptokinase complex]
    T V Hrynenko
    Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv
    Ukr Biokhim Zh 74:50-7. 2002
    ..During this time alpha 2-antiplasmin (alpha 2-AP) has any effect on amidolytic activity of the complex...
  69. ncbi [Evaluation of selected parameters of blood coagulation and fibrinolysis system in patients undergoing total hip replacement surgery with normovolemic hemodilution procedure and standard enoxaparine prophylaxis]
    Wiesław Piecuch
    Oddział Urazowo Ortopedyczny, SPZOZ w Chełmie
    Chir Narzadow Ruchu Ortop Pol 68:95-9. 2003
    ..We determined the concentrations of TAT and PAP complexes, prothrombin fragments 1 + 2 (F1 + 2) and d-dimers (DD)...
  70. ncbi Extended monitoring of hemostatic activation after varicose vein surgery under general anesthesia
    Gabriele Hinterhuber
    Department of Dermatology, Division of General Dermatology, Medical University of Vienna, Vienna, Austria
    Dermatol Surg 32:632-9. 2006
    ..Postoperative heparin prophylaxis after stripping of the long saphenous vein is a matter of controversial discussion, and practices vary by surgeon and country...
  71. ncbi Prospective study of fibrinolytic markers and venous thromboembolism
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
    J Clin Epidemiol 56:598-603. 2003
    ..participants who developed VTE and 640 controls, we measured PAI-1 antigen, tPA/PAI-1 complex, plasmin-alpha 2-antiplasmin (PAP), and the PAI-1 -675 4G/5G promoter polymorphism on pre-event blood samples...
  72. ncbi Implications of fibrinogenolysis in patients with closed head injury
    Shigeki Kushimoto
    Department of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan
    J Neurotrauma 20:357-63. 2003
    ..Decreased activity of alpha2-plasmin inhibitor may contribute to fibrinogenolysis...
  73. ncbi Coagulation-fibrinolysis abnormalities in patients receiving antiparkinsonian agents
    Yoshihiro Sato
    Department of Rehabilitation Medicine, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    J Neurol Sci 212:55-8. 2003
    ..time (international normalized ratio) and plasma levels of prothrombin fragment(1+2), D-dimer, plasmin-alpha 2 antiplasmin complex, thrombomodulin and E-selectin were higher in patients receiving antiparkinsonian agents as compared to ..
  74. ncbi An analysis of mechanisms underlying the antifibrinolytic properties of radiographic contrast agents
    P M Farrehi
    Department of Internal Medicine (Cardiology, University of Michigan Medical School, Ann Arbor, MI 48109-0644, USA
    J Thromb Thrombolysis 12:273-81. 2001
    ..Contrast agents did not affect plasminogen activator inhibitor-1 or alpha(2)-antiplasmin function...
  75. ncbi [Activation of fibrynolysis in children with chronic B or C hepatitis]
    Kinga Michalska
    Katedra i Klinika Pediatrii Alergologii i Gastroenterologii Akademii Medycznej w Bydgoszczy
    Pol Merkur Lekarski 17:316-20. 2004
    ..There are little data about fibrynolysis in patient with chronic viral hepatitis. The aim of the study was to evaluate selected fibrinolytic parameters in children with chronic B or C hepatitis...
  76. ncbi Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice
    Hiroyuki Matsuno
    Department of Pharmacology, Gifu University School of Medicine, Japan
    Thromb Haemost 87:98-104. 2002
    The role of plasminogen (Plg) and alpha2-antiplasmin (alpha2-AP) in vascular thrombolysis in vivo was investigated in mice deficient in plasminogen (Plg-/-) or a2-AP (alpha2-AP-/-) or their wild type (PAI-1+/+, alpha2-AP+/+)...
  77. pmc Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia
    Faisal Adhami
    Division of Developmental Biology and Division of Neurology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Am J Pathol 172:1704-16. 2008
    ..Consistent with this hypothesis, injection of alpha2-antiplasmin into cerebral ventricles markedly ameliorated HI-induced damage to neurofilaments and white matter ..
  78. ncbi Like fibrin, (DD)E, the major degradation product of crosslinked fibrin, protects plasmin from inhibition by alpha2-antiplasmin
    A Y Lee
    Department of Medicine, McMaster University and Hamilton Civic Hospitals Research Centre, Ontario, Canada
    Thromb Haemost 85:502-8. 2001
    ..To ensure efficient fibrinolysis, plasmin bound to fibrin is protected from inhibition by alpha2-antiplasmin. (DD)E, a major soluble degradation product of cross-linked fibrin that is a potent stimulator of t-PA, ..
  79. ncbi [Atypical defibrination syndromes and acute leukemias with a t(9,22) translocation, apropos of 2 cases]
    B Meddeb
    , , place du Gouvernement, La Kasbah, 1007 Tunis, Tunisie
    Pathol Biol (Paris) 49:232-6. 2001
    ..Hemostasis studies show low fibrinogen level, elevated D-dimers, decreased alpha 2 antiplasmin and factor V, normal antithrombin III values. Plasminogen is below the normal range in one patient...
  80. ncbi Effect of high-dose progestogen on hemostatic properties of blood in patients with endometrial cancer
    M Kaibara
    Department of Obstetrics and Gynecology, Ichihara Hospital, School of Medicine, Teikyo University, Ichihara City, Chiba, Japan
    Clin Hemorheol Microcirc 24:93-9. 2001
    ..Accelerated coagulation of blood was definitely induced by high-dose MPA but antithrombin and fibrinolytic activities were also induced, and, thus, thromboembolic complications were prevented...
  81. ncbi Characterization of the murine plasma fibrinolytic system
    H R Lijnen
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Eur J Biochem 224:863-71. 1994
    The main components of the murine plasma fibrinolytic system, including fibrinogen, plasminogen, alpha 2-antiplasmin, tissue-type plasminogen activator and plasminogen activator inhibitor-1, were purified to homogeneity and their ..
  82. ncbi An enhanced fibrinolysis prevents the development of multiple organ failure in disseminated intravascular coagulation in spite of much activation of blood coagulation
    H Asakura
    Department of Internal Medicine (III, Kanazawa University School of Medicine, Takaramachi 13-1, Kanazawa 920-8641, Japan
    Crit Care Med 29:1164-8. 2001
    ..The increases in plasma levels of t-PA and PAI were poor prognostic markers in DIC. Further careful study may be useful to clarify whether the fibrinolytic therapy is beneficial in clinical DIC patients with MOF...
  83. ncbi Comparison of three commercially available hollow fiber oxygenators: gas transfer performance and biocompatibility
    R de Vroege
    Department of Extracorporeal Circulation, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    ASAIO J 47:37-44. 2001
    ..However, this oxygenator elevated oxygen partial pressure the most and reduced carbon dioxide partial pressure the most. In group 2, where a smaller venous reservoir was used, the highest blood activation was observed...
  84. ncbi Plasma levels of total plasminogen activator inhibitor-I (PAI-I) and tPA/PAI-1 complex in patients with disseminated intravascular coagulation and thrombotic thrombocytopenic purpura
    R Watanabe
    DepartmentSecond Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Japan
    Clin Appl Thromb Hemost 7:229-33. 2001
    ..In all cases, total PAI-I or tPA/PAI-I complex was not significantly correlated with any hemostatic marker. Measurement of total PAI-I and tPA/PAI-I complex may be useful in the diagnosis of DIC...
  85. ncbi A possible role of thrombin-activatable fibrinolysis inhibitor in disturbances of fibrinolytic system in renal transplant recipients
    T Hryszko
    Department of Nephrology and Internal Medicine, Medical Academy of Bialystok, Bialystok, Zurawia, Poland
    Nephrol Dial Transplant 16:1692-6. 2001
    ..thrombomodulin (sTM), prothrombin fragments F1+2 (F1+2), thrombin--antithrombin complexes (TAT), plasmin--antiplasmin complexes (PAP), and TAFI were measured with commercially available kits...
  86. ncbi Early inhibition of activated fibrinolysis predicts microbial infection, shock and mortality in febrile medical patients
    J Raaphorst
    Medical Intensive Care Unit, Department of Internal Medicine, Institute of Cardiovascular Research, Free University Hospital, Amsterdam, The Netherlands
    Thromb Haemost 86:543-9. 2001
    ..and daily thereafter for two days, circulating thrombin-antithrombin III (TAT) complexes, plasmin-alpha2-antiplasmin (PAP) complexes (day 0 only), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-..
  87. ncbi Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burns
    K Aoki
    Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, 160-8582, Tokyo, Japan
    Burns 27:569-75. 2001
    ....
  88. ncbi The antithrombotic effect of dextran-40 in man is due to enhanced fibrinolysis in vivo
    Chris I Jones
    Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
    J Vasc Surg 48:715-22. 2008
    ..In rats, dextran blocks uptake of tissue plasminogen activator (tPA) by mannose-binding receptors. Because this would have the effect of enhancing endogenous fibrinolysis, we explored this effect of dextran-40 on fibrinolysis in man...
  89. ncbi Evidence for an active fibrinolytic system in normal human bone marrow
    N A McWilliam
    Department of Molecular and Cell Biology, University of Aberdeen, Marischal College
    Br J Haematol 93:170-6. 1996
    ..The t-PA was in an active form, despite the presence of the inhibitors PAI-1 and PAI-2. Plasminogen and alpha2-antiplasmin (alpha2-AP) were also present in marrow...
  90. ncbi Comparison of the responses of global tests of coagulation with molecular markers of neutrophil, endothelial, and hemostatic system perturbation in the baboon model of E. colisepsis--toward a distinction between uncompensated overt DIC and compensated non
    H Wada
    Second Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Thromb Haemost 86:1489-94. 2001
    ..observed that molecular markers, soluble thrombomodulin and elastase, unlike thrombin/antithrombin and plasmin/antiplasmin complexes, remained elevated out to T+24 to 48 h indicating endothelial injury that persists beyond the initial ..
  91. ncbi Longitudinal stability of coagulation, fibrinolysis, and inflammation factors in stored plasma samples
    M R Lewis
    Department of Pathology, University of Vermont College of Medicine, Burlington, USA
    Thromb Haemost 86:1495-500. 2001
    ..D-dimer, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor-1, protein C, protein S, and tissue plasminogen activator), totaling ..
  92. ncbi Hemostasis during normal pregnancy and puerperium
    Margareta Hellgren
    Department of Obstetrics and Gynecology, Göteborg University and Sahlgrenska University Hospital, Sweden
    Semin Thromb Hemost 29:125-30. 2003
    ..prothrombin fragment 1+2, thrombin-antithrombin complex, fibrinopeptide A, soluble fibrin, D-dimer, and plasmin-antiplasmin complex...
  93. ncbi Effect of two low-dose gestodene containing monophasic oral contraceptives on hemostasis in Bulgarian women
    Ekaterina Uchikova
    Department of Obstetrics and Gynecology, Medical University, 4000 Plovdiv, Bulgaria
    Expert Opin Pharmacother 9:1839-44. 2008
    ..To compare the effects of two monophasic oral contraceptives upon coagulation, fibrinolysis and the system of natural inhibitors (anticoagulant pathways) in Bulgarian women...
  94. ncbi Fibrinolysis in glomerulonephritis treated with ancrod: renal functional, immunologic and histopathologic effects
    S Kim
    Department of Internal Medicine, University of Cincinnati Medical Center, Ohio 45267
    Q J Med 69:879-905. 1988
    ..products derived from ancrod-cleaved-fibrinogen in the circulating pool; in most, level of plasma alpha 2-antiplasmin before treatment was elevated...
  95. ncbi Cutaneous and systemic effects of varying doses of brown recluse spider venom in a rabbit model
    David L McGlasson
    Clinical Research Squadron MSRL, Lackland AFB, TX 78236 5300, USA
    Clin Lab Sci 20:99-105. 2007
    ..Establishment of a dose-response relationship is an important first step in determining if the NZW rabbit is a suitable model to study both cutaneous and systemic effects of the venom...
  96. ncbi Degradation of host protease inhibitors and activation of plasminogen by proteolytic enzymes from Porphyromonas gingivalis and Treponema denticola
    D Grenier
    Faculte de Medecine Dentaire, Universite Laval, Sainte Foy, Quebec, Canada
    Microbiology 142:955-61. 1996
    ..of host protease inhibitors (alpha-1-antitrypsin, antichymotrypsin, alpha 2-macroglobulin, antithrombin III, antiplasmin and cystatin C) was evaluated by SDS-PAGE. The 80 kDa trypsin-like protease of P...
  97. ncbi Activation of the fibrinolytic system and utilization of the coagulation inhibitors in sepsis: comparison with severe sepsis and septic shock
    A C Mavrommatis
    Department of Critical Care, General Hospital of Nikea, 3 Mandouvalou D St, 18454 Piraeus, Greece
    Intensive Care Med 27:1853-9. 2001
    ....
  98. ncbi Effect of gamma irradiation with 30 Gy on the coagulation system in leukoreduced fresh-frozen plasma
    Volker Weisbach
    Department of Transfusion Medicine and Hemostaseology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Transfusion 47:1658-65. 2007
    ..The aim of this study was to investigate the effect of gamma irradiation with 30 Gy on the coagulation system in leukoreduced fresh-frozen plasma (FFP)...
  99. ncbi A comprehensive study on hemostasis in CAPD patients treated with erythropoietin
    Jolanta Malyszko
    Department of Nephrology and Internal Medicine, Bialystok University School of Medicine, Bialystok, Poland
    Perit Dial Int 22:582-92. 2002
    ..thrombin-antithrombin complexes (TAT) and prothrombin fragments 1+2; a marker of ongoing fibrinolysis: plasmin-antiplasmin complexes (PAP); fibrinolytic activity: euglobulin clot lysis time (ECLT); and markers of endothelial cell ..
  100. ncbi Protein C as an early marker of severe septic complications in diffuse secondary peritonitis
    Aleksandar Karamarkovic
    Center for Emergency Surgery, Clinical Center of Serbia, School of Medicine, University of Belgrade, Pasteur 2 str, 11000, Belgrade, Serbia and Montenegro
    World J Surg 29:759-65. 2005
    ..C levels were repeatedly determined and compared with serum levels of antithrombin III, plasminogen, alpha(2)-antiplasmin, Plasminogen activator inhibitor, D-dimer, C1-inhibitor, high molecular weight kininogen, and the C5a, C5b-9 ..
  101. ncbi Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes
    S V Pizzo
    Department of Pathology and Biochemistry, Duke University Medical Center, Durham, North Carolina
    Am J Med 87:10S-14S. 1989
    ..Proteinase complexes with alpha 2-antiplasmin, another member of the serpin class, do not bind to serpin receptor 1...

Research Grants36

  1. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    ..physiological activities of several omptin proteases, including inhibition of the degradation of alpha-2- antiplasmin and antimicrobial peptides, as well as inhibition of invasion of cultured cells by Y. pestis...
  2. Role of the Plasminogen Activator Protease during Pneumonic Plague
    Wyndham W Lathem; Fiscal Year: 2013
    ..In addition, Pla inactivates 12-antiplasmin, the major inhibitor of plasmin...
  3. Plasminogen Activation &SK: Structure-Function
    Guy L Reed; Fiscal Year: 2012
    ..Plasmin generation and activity is tightly regulated by protein interactions with inhibitors (e.g., 12-antiplasmin), substrates (e.g., fibrin) and other molecules...
  4. PA/PLASMIN/GELATINASE CASCADE IN DIABETIC NEPHROPATHY
    WILLIAM BARICOS; Fiscal Year: 2000
    ..by interactions among matrix degrading proteinases (gelatinase, plasmin), their inhibitors (TIMPs and alpha-2-antiplasmin), and specific modulators (polypeptide growth factors, reactive oxygen metabolites) produced by MC and/or ..
  5. PROTEINASE IN FIBRINOLYSIS AND THROMBOLYTIC THERAPY
    STEVEN GONIAS; Fiscal Year: 1993
    ..Modulation of synthesis by factors generated during thrombolysis, such as fibrinogen fragment D, alpha2-antiplasmin- plasmin complex an hepatocyte stimulating factor, will be studied...
  6. INTERACTION OF GROUP A STREP WITH THE PLASMINOGEN SYSTEM
    Michael Boyle; Fiscal Year: 2001
    ..proteolytic enzymatic activity, which cannot be inhibited by physiological protease inhibitors like alpha-2 antiplasmin. These pathways include direct binding of plasmin to surface binding proteins, as well as a more complicated ..
  7. tPA Neurotoxicity in Hypoxic-Ischemia Encephalopathy
    Chia Yi Kuan; Fiscal Year: 2009
    ..In Aim 2, we will compare the effects of cerebroventricular injection of a2-antiplasmin (a Plasmin inhibitor), PAI-1 (inhibiting both tPA and uPA), and neuroserpin (tPA-specific but covering plasmin-..
  8. Novel Methods for Dissolving Blood Clots
    GUY LELAND REED; Fiscal Year: 2010
    ..Studies of humans and mice with lifelong deficiency of a2-antiplasmin (a2AP) have shown that it is the major regulator of blood clot dissolution...
  9. N3 FATTY ACIDS EFFECT ON SICKLE CELL PAIN EPISODES
    James Eckman; Fiscal Year: 2001
    ..platelet factor 4 (PF4) and beta-thromboglobulin (betaTG), and products of fibrinolysis including plasmin-antiplasmin complex (PAP) and D-dimer...
  10. FIBRINOGEN--ROLE OF THE GAMMA VARIANT
    David Farrell; Fiscal Year: 2001
    ..The results from the experiments in this proposal should provide new knowledge about the process of blood coagulation that may lead to way of modulating fibrin clot stability and clot lysis in vivo. ..
  11. NMR Studies of Plasminogen and Related Genomic Domains
    Miguel Llinas; Fiscal Year: 2004
    ..The Pgn kringles interact with the inhibitor a2-antiplasmin C- and the Pgn N-terminal peptide domains...
  12. ENHANCING THROMBOLYSIS BY INHIBITION OF A2-ANTIPLASMIN
    Guy Reed; Fiscal Year: 1993
    ..previous attempts to improve the safety and efficacy of this therapy have all by ignored alpha2-antiplasmin (alpha2AP), the chief inhibitor of clot lysis...
  13. TRANSGLUTAMINASE INHIBITORS AND SOLID PHASE SUBSTRATES
    MARY TRAWICK; Fiscal Year: 1991
    ..In related studies, peptide sequences on solid supports will then be tested as a substrates for the development of a standardized, solid-phase assay for Factor XIIIa...
  14. Alpha2-antiplasmin polymorphism and a new plasma enzyme
    Patrick McKee; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The serpin alpha2-antiplasmin (a2AP) has a major role in regulating fibrinolysis...
  15. ROLE OF FIBRINOGEN IN FIBRINOLYSIS
    David Farrell; Fiscal Year: 2004
    ..The results from the experiments in this proposal should provide new knowledge about the process of fibrinolysis that may lead to ways of modulating fibrin clot stability and clot lysis in vivo. ..
  16. Enhancement of Thrombolysis through Inhibition of PAI-1 and Antiplasmin
    CHARLENE BLAKE; Fiscal Year: 2007
    ..that reversible inhibition of the antifibrinolytic proteins plasminogen activator inhibitor-1 (PAI-1) and antiplasmin through aptamer-antidote pairs can produce safe and effective thrombolysis for treatment of stroke...
  17. Site Directed Thrombolytic Agent
    ELEANOR MCGOWAN; Fiscal Year: 2003
    ..Local delivery of plasmin and its rapid inhibition by alpha2 antiplasmin distal to the clot site will limit bleeding side effects...
  18. A NOVEL COLORIMETRIC ENZYME ASSAY FOR FIBRINOLYSIS
    Mark Triscott; Fiscal Year: 1990
    ..The factors of interest include the activators t-PA and urokinase, the plasmin inhibitor, alpha2 - antiplasmin and the activator inhibitor, PAI-1 (plasminogen activator inhibitor -1)...
  19. NON-RESPONDERS FOLLOWING VENOUS OCCLUSION
    Karol Lacroix; Fiscal Year: 1991
    ..major inhibitor to t-PA, Protein C antigen and activity levels, kallikrein, Factor XII, plasminogen, alpha-2 antiplasmin, serum lipids, lipoproteins, and apolipoproteins...
  20. SULFATION OF HUMAN PLASMA PROTEINS
    Glen Hortin; Fiscal Year: 1991
    ..Three human plasma proteins-- the fourth component of complement (C4), heparin cofactor II, and alpha2-antiplasmin-- which contain tyrosine sulfate residues will be analyzed in detail...
  21. SAFER THROMBOLYTIC THERAPY USING PLASMIN
    Victor Marder; Fiscal Year: 2007
    ..the hemostatic safety of plasmin in animal models of bleeding, using the rabbit ear puncture model to evaluate antiplasmin as a safety monitoring tool and as an antidote for bleeding and a rabbit embolic stroke model to assess the ..
  22. PLASMINOGEN ACTIVATION--STRUCTURE ACTIVITY ANALYSIS
    Edward Reich; Fiscal Year: 1999
    ..and the bacterial activator streptokinase; iii) a complex of microplasmin and the plasma inhibitor alpha 2-antiplasmin; and iv) native Glu-plasminogen...
  23. Structural Mechanisms for the Inhibition of Thrombosis
    JAMES HUNTINGTON; Fiscal Year: 2009
    ....
  24. Secretion in Vascular Inflammation and Thrombosis
    Guy Reed; Fiscal Year: 2007
    ..These experiments should define whether targeting these molecules to inhibit the platelet alpha and/or dense granule secretion could be an effective therapeutic strategy for reducing cardiovascular disease. ..
  25. Thrombomodulin Links Coagulation to Inflammation
    Edward Conway; Fiscal Year: 2006
    ..The results of the studies, to be tested in an excellent environment, will hopefully provide new insights that will lead to the design of more effective therapeutic approaches for inflammatory disease. ..
  26. Chronic Thromboembolic Pulmonary Hypertension
    TIMOTHY MORRIS; Fiscal Year: 2006
    ..The fragments will be subjected to liquid chromatography-mass spectroscopy with data-dependent MS-2 data acquisition, followed by computer-assisted sequence analysis. ..
  27. MECHANISMS OF DILATED CARDIOMYOPATHY IN CREB A133
    Guy Reed; Fiscal Year: 2002
    ..Taken together the results of this work should provide us with important new insights into the molecular mechanisms underlying human DC and CHF. ..
  28. POSTDOCTORAL HEMATOLOGY RESEARCH TRAINING
    George Dale; Fiscal Year: 2003
    ..Francis Fdt. (OUHSC). All members of the faculty work closely together under Specialized Center of Research (SCOR) and Program Project (PP)...
  29. MECHANISM OF HUMAN MAST CELL TRYPTASE REGULATION
    Norman Schechter; Fiscal Year: 2003
    ..Understanding the structural properties responsible for the functional instability may provide new targets for therapeutic inhibitors. ..
  30. DIET, IMMUNE MODULATION, AND ASTHMA IN EARLY LIFE
    Scott Weiss; Fiscal Year: 2002
    ....
  31. EXTRAVASCULAR THROMBIN REGULATION BY HEPARIN COFACTOR II
    FRANK CHURCH; Fiscal Year: 2004
    ..Understanding the molecular and cellular properties of HCII may lead to new insight into the pathophysiology and therapies of cardiovascular diseases. ..
  32. THE ROLE OF HYALURONAN IN AIRWAY HYPERREACTIVITY
    Rosanna Forteza; Fiscal Year: 2005
    ..Thus, the results of this proposal will not only significantly advance our knowledge of airway biology and asthma, but may have important implications to other mucosal surfaces as well. ..
  33. COAT-Platelets
    George Dale; Fiscal Year: 2005
    ..alpha-granule proteins including von Willebrand factor, fibrinogen, fibronectin, thrombospondin and alpha2-antiplasmin, bound at high levels...
  34. The Genetic Epidemiology of Asthma in Costa Rica
    Scott Weiss; Fiscal Year: 2005
    ..Thus, this proposal will greatly contribute to our understanding of the pathogenesis of a significant public health problem among Hispanic Americans: bronchial asthma. ..
  35. ADMINISTRATIVE/EDUCATION CENTER FOR INNATE IMMUNITY PGA
    Scott Weiss; Fiscal Year: 2004
    ..abstract_text> ..
  36. SERINE PROTEASES FROM MAST CELLS AND SKIN
    Norman Schechter; Fiscal Year: 2002
    ..It is hoped that these studies will advance our understanding of two classes of molecules which are important to production and regulation of inflammation. ..