tenascin

Summary

Summary: Hexameric extracellular matrix glycoprotein transiently expressed in many developing organs and often re-expressed in tumors. It is present in the central and peripheral nervous systems as well as in smooth muscle and tendons. (From Kreis & Vale, Guidebook to the Extracellular Matrix and Adhesion Proteins, 1993, p93)

Top Publications

  1. ncbi Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    Kim Midwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Nat Med 15:774-80. 2009
  2. ncbi A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment
    Dion A Daniels
    Gene Expression and Protein Biochemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, England
    Proc Natl Acad Sci U S A 100:15416-21. 2003
  3. ncbi Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid
    A Laitinen
    Department of Anatomy, University of Helsinki, Finland
    Am J Respir Crit Care Med 156:951-8. 1997
  4. ncbi Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction
    K Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Mie, Japan
    Lab Invest 81:1015-24. 2001
  5. ncbi Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth
    P L Jones
    Division of Cardiovascular Research, Research Institute, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Cell Biol 139:279-93. 1997
  6. ncbi Tenascin-C is a useful marker for disease activity in myocarditis
    Kyoko Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Japan
    J Pathol 197:388-94. 2002
  7. ncbi Opposite effect of fluticasone and salmeterol on fibronectin and tenascin-C expression in primary human lung fibroblasts
    M Degen
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Clin Exp Allergy 39:688-99. 2009
  8. ncbi Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population
    M Fukunaga-Kalabis
    Molecular and Cellular Oncogenesis Program, Division of Molecular and Cellular Biology, The Wistar Institute, Philadelphia, PA 19104, USA
    Oncogene 29:6115-24. 2010
  9. ncbi Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma
    Christoph Schliemann
    Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Leuk Res 33:1718-22. 2009
  10. ncbi Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells
    Keiki Nagaharu
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Mie, Japan
    Am J Pathol 178:754-63. 2011

Research Grants

  1. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2007
  2. STRUCTURAL AND BIOCHEMICAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE FUNCTION
    Samuel Bouyain; Fiscal Year: 2010
  3. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2003
  4. Genomic targets of oncoproteins and tumor suppressors
    Kevin Struhl; Fiscal Year: 2010
  5. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2003
  6. MACROMOLECULAR ARRAYS IN EXTRACELLULAR MATRIX OF COCHLEA
    Vladimir Tsuprun; Fiscal Year: 2003
  7. MOLECULAR ANALYSIS OF NOVEL BRAIN PROTEOGLYCANS
    Yu Yamaguchi; Fiscal Year: 1999
  8. Tenascin in Chondrosarcoma Metastasis
    Sean Scully; Fiscal Year: 2004
  9. Matrix Metalloproteinases and Regenerative Plasticity Following Brain Injury
    Linda L Phillips; Fiscal Year: 2010
  10. Matrix Metalloproteinases and Regenerative Plasticity Following Brain Injury
    Linda Phillips; Fiscal Year: 2009

Detail Information

Publications248 found, 100 shown here

  1. ncbi Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    Kim Midwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Nat Med 15:774-80. 2009
    ..b>Tenascin-C (encoded by Tnc) is an extracellular matrix glycoprotein specifically expressed at areas of inflammation and ..
  2. ncbi A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment
    Dion A Daniels
    Gene Expression and Protein Biochemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, England
    Proc Natl Acad Sci U S A 100:15416-21. 2003
    ..Here we characterize the interaction of the DNA aptamer, GBI-10, with tenascin-C, an extracellular protein found in the tumor matrix...
  3. ncbi Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid
    A Laitinen
    Department of Anatomy, University of Helsinki, Finland
    Am J Respir Crit Care Med 156:951-8. 1997
    b>Tenascin and fibronectin are extracellular matrix glycoproteins expressed during morphogenesis and tissue repair...
  4. ncbi Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction
    K Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Mie, Japan
    Lab Invest 81:1015-24. 2001
    b>Tenascin-C (TNC), an extracellular matrix glycoprotein, plays important roles in tissue remodeling. TNC is not normally expressed in adults but reappears under pathologic conditions...
  5. ncbi Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth
    P L Jones
    Division of Cardiovascular Research, Research Institute, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Cell Biol 139:279-93. 1997
    b>Tenascin-C (TN-C) is induced in pulmonary vascular disease, where it colocalizes with proliferating smooth muscle cells (SMCs) and epidermal growth factor (EGF)...
  6. ncbi Tenascin-C is a useful marker for disease activity in myocarditis
    Kyoko Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Japan
    J Pathol 197:388-94. 2002
    b>Tenascin-C (TNC) is an extracellular matrix protein which appears at active sites of tissue remodelling during embryogenesis or cancer invasion...
  7. ncbi Opposite effect of fluticasone and salmeterol on fibronectin and tenascin-C expression in primary human lung fibroblasts
    M Degen
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Clin Exp Allergy 39:688-99. 2009
    ..Current therapies for asthma and COPD consist of inhaled corticosteroids and long-acting beta(2)-agonists (LABA). However, their effect on airway remodelling is not well understood so far...
  8. ncbi Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population
    M Fukunaga-Kalabis
    Molecular and Cellular Oncogenesis Program, Division of Molecular and Cellular Biology, The Wistar Institute, Philadelphia, PA 19104, USA
    Oncogene 29:6115-24. 2010
    b>Tenascin-C (TNC) is highly expressed in melanoma; however, little is known about its functions. Recent studies indicate that TNC has a role within the stem cell niche...
  9. ncbi Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma
    Christoph Schliemann
    Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Leuk Res 33:1718-22. 2009
    ..are clinical-stage human monoclonal antibodies, which selectively recognize splice isoforms of fibronectin and tenascin-C in the modified extracellular matrix of neoplastic lesions...
  10. ncbi Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells
    Keiki Nagaharu
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Mie, Japan
    Am J Pathol 178:754-63. 2011
    b>Tenascin C (TNC) is an extracellular matrix glycoprotein up-regulated in solid tumors. Higher TNC expression is shown in invading fronts of breast cancer, which correlates with poorer patient outcome...
  11. ncbi Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture
    Isao Kii
    Department of Biological Information, Tokyo Institute of Technology, 4259 Midori ku, Nagatsuta, Yokohama 226 8501
    J Biol Chem 285:2028-39. 2010
    ..Here we show that periostin, a matricellular protein, promotes incorporation of tenascin-C into the ECM and organizes a meshwork architecture of the ECM...
  12. ncbi Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse
    Hiroki Nakahara
    Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu City, Japan
    Eur J Immunol 36:3334-45. 2006
    b>Tenascin C (TN-C) is an extracellular matrix glycoprotein whose expression is increased in several inflammatory diseases of the lung, including bronchial asthma...
  13. ncbi Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development
    Joy Lincoln
    Division of Molecular Cardiovascular Biology, MLC 7020, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 294:292-302. 2006
    ..This review will focus on the regulatory hierarchies that control normal and abnormal heart valve development in parallel with other connective tissue cell types...
  14. ncbi Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma
    E M Karjalainen
    Clinical Research Unit of Pulmonary Medicine, Department of Medicine, Helsinki University Central Hospital, Finland
    Respir Med 97:1045-51. 2003
    ..study was set to investigate the bronchial inflammatory cell infiltrate and subepithelial basement membrane (BM) tenascin deposition in subjects with newly diagnosed asthma and bronchial hyperresponsiveness (BHR)...
  15. ncbi Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteins
    N Dandachi
    Institute of Pathological Anatomy, Landeskliniken Salzburg, Salzburg, Austria
    J Pathol 193:181-9. 2001
    ..In human breast carcinomas, up-regulation of tenascin-C (TN-C) and vimentin (Vim) is frequently observed in cancer cells and correlates with increased malignancy...
  16. ncbi Mice develop normally without tenascin
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Genes Dev 6:1821-31. 1992
    b>Tenascin, an extracellular matrix protein, is expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena...
  17. ncbi Tenascins: regulation and putative functions during pathological stress
    Ruth Chiquet-Ehrismann
    Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Pathol 200:488-99. 2003
    ..The article is divided into the following sections: Introduction: the tenascin family of extracellular matrix proteins; Structural roles: tenascin-X deficiency and Ehlers-Danlos syndrome; ..
  18. ncbi Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin
    Gesa Rascher
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, Germany
    Acta Neuropathol 104:85-91. 2002
    ..despite a high variability of vascular phenotypes, the loss of agrin strongly correlated with the expression of tenascin, an extracellular matrix molecule which has been described previously to be absent in mature non-pathological ..
  19. ncbi Distribution pattern of tenascin-C in glioblastoma: correlation with angiogenesis and tumor cell proliferation
    Senija Behrem
    Department of Pathology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    Pathol Oncol Res 11:229-35. 2005
    b>Tenascin-C (TN-C) is an extracellular matrix protein which participates in different processes like normal fetal development, wound healing, inflammation, keloids and rheumatoid arthritis...
  20. ncbi VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
    Joyce T O'Connell
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:16002-7. 2011
    ..with a concomitant decrease in the expression of several ECM molecules and growth factors, particularly Tenascin-C and VEGF-A...
  21. ncbi Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation
    W Huang
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Cancer Res 61:8586-94. 2001
    b>Tenascin-C is an adhesion-modulatory extracellular matrix molecule that is highly expressed in tumors...
  22. ncbi Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrix glycoprotein tenascin-R
    A K Saghatelyan
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, Hamburg, D 20246, Germany
    Mol Cell Neurosci 17:226-40. 2001
    The role of the extracellular matrix molecule tenascin-R (TN-R) in regulation of synaptic transmission and plasticity in the CA1 region of the hippocampus was studied using mice deficient in expression of this molecule...
  23. ncbi Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization
    Katrin Lange
    Center for Biomedicine, Department of Clinical and Biological Sciences, University of Basel, Basel, Switzerland
    Cancer Res 67:6163-73. 2007
    b>Tenascin-C, an extracellular matrix molecule of the tumor-specific microenvironment, counteracts the tumor cell proliferation-suppressing effect of fibronectin by blocking the integrin alpha(5)beta(1)/syndecan-4 complex...
  24. ncbi Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Circ J 71:327-30. 2007
    b>Tenascin-C (TN-C), an extracellular matrix glycoprotein, is specifically expressed at high levels during embryonic development, but not in the adult heart...
  25. ncbi Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension
    Kaori Ihida-Stansbury
    University of Pennsylvania, Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, Philadelphia, PA 19104 6383, USA
    Am J Physiol Lung Cell Mol Physiol 291:L694-702. 2006
    ..Here we show that pulmonary vascular lesions from patients harboring BMPR2 mutations express high levels of tenascin-C (TN-C), an extracellular matrix glycoprotein that promotes pulmonary artery (PA) smooth muscle cell (SMC) ..
  26. ncbi Expression of N-cadherin, N-CAM, fibronectin and tenascin is stimulated by TGF-beta1, beta2, beta3 and beta5 during the formation of precartilage condensations
    J Chimal-Monroy
    Department of Cell Biology, Instituto de Investigaciones Biomedicas, UNAM, Mexico D F, Mexico
    Int J Dev Biol 43:59-67. 1999
    ..relationship between adhesion molecules (N-cadherin and N-CAM), extracellular matrix proteins (fibronectin and tenascin) and TGF-beta1, TGF-beta2 and TGF-beta3 during in vitro precartilage condensations in mouse chondrogenesis...
  27. ncbi Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains
    Y Yokosaki
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Biol Chem 271:24144-50. 1996
    ..For example, at least 5 different integrins recognize tenascin as a ligand, and 4 of these bind to the same region of the protein, the third fibronectin type III repeat (TNfn3)...
  28. ncbi From mechanotransduction to extracellular matrix gene expression in fibroblasts
    Matthias Chiquet
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Biochim Biophys Acta 1793:911-20. 2009
    ..actin dynamics directly to the expression of specific genes, among them the extracellular matrix protein tenascin-C...
  29. ncbi Polymorphism and expression of the porcine Tenascin C gene associated with meat and carcass quality
    A Kayan
    Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany
    Meat Sci 89:76-83. 2011
    The research aimed to screen for polymorphism, expression of Tenascin C (TNC) and association with meat and carcass quality traits. Three single nucleotide polymorphisms were detected. In a Duroc×Pietrain F2 cross (DuPi) population, g...
  30. ncbi Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration
    Melissa R Andrews
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 2PY, United Kingdom
    J Neurosci 29:5546-57. 2009
    ..They also lack an integrin that interacts with tenascin-C, the main extracellular matrix glycoprotein of the CNS, which is upregulated after injury...
  31. ncbi A multimodal nanoparticle-based cancer imaging probe simultaneously targeting nucleolin, integrin αvβ3 and tenascin-C proteins
    Hae Young Ko
    Laboratory of Molecular Imaging, Department of Applied Bioscience, CHA Stem Cell Institute, CHA University, 605 21 Yoeksam 1 dong, Gangnam Gu, Seoul 135 081, Republic of Korea
    Biomaterials 32:1130-8. 2011
    ..The results demonstrated that the SMART cancer probe will be useful for the diagnosis of different cancers as a cancer master probe...
  32. ncbi Teneurin-1 is expressed in interconnected regions of the developing brain and is processed in vivo
    Daniela Kenzelmann
    Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstr 66, 4057 Basel, Switzerland
    BMC Dev Biol 8:30. 2008
    ..elegans and D. melanogaster to mammals. In vertebrates there are four paralogs (teneurin-1 to -4), all of which are expressed prominently in the developing central nervous system...
  33. ncbi Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension
    Jorge Correia-Pinto
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho, Braga, Portugal
    Basic Res Cardiol 104:535-45. 2009
    ..Cardiomyocyte apoptosis was evaluated by TUNEL assay. Extracellular matrix composition was evaluated by tenascin-C mRNA levels and interstitial collagen content...
  34. ncbi Suppression subtractive hybridization identifies distinctive expression markers for coronary and internal mammary arteries
    Minghui Qin
    Atherosclerosis Research Center, Division of Cardiology, and Burns and Allen Research Institute, Cedars-Sinai Medical Center, Davis Bldg #1016, 8700 Beverly Blvd, Los Angeles, Calif 90048, USA
    Arterioscler Thromb Vasc Biol 23:425-33. 2003
    ..These differences may partly explain the resistance of coronary arteries and internal mammary arteries to atherosclerosis...
  35. ncbi Role of RhoA/ROCK-dependent actin contractility in the induction of tenascin-C by cyclic tensile strain
    Ana Sarasa-Renedo
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, P O Box 54, Switzerland
    Exp Cell Res 312:1361-70. 2006
    In chick embryo fibroblasts, the mRNA for extracellular matrix protein tenascin-C is induced 2-fold by cyclic strain (10%, 0.3 Hz, 6 h). This response is attenuated by inhibiting Rho-dependent kinase (ROCK)...
  36. ncbi Tenascin-C is involved in motor axon outgrowth in the trunk of developing zebrafish
    Jörn Schweitzer
    Zentrum für Molekulare Neurobiologie, Hamburg, Germany
    Dev Dyn 234:550-66. 2005
    ..b>Tenascin-C, a component of the extracellular matrix, is concentrated in this choice region...
  37. ncbi Cell-adhesive responses to tenascin-C splice variants involve formation of fascin microspikes
    D Fischer
    Friedrich Miescher Institut, Basel, Switzerland
    Mol Biol Cell 8:2055-75. 1997
    b>Tenascin-C is an adhesion-modulating matrix glycoprotein that has multiple effects on cell behavior...
  38. ncbi Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice
    Tomohiro Nishioka
    Dept of Pathology and Matrix Biology, Mie Univ Graduate School of Medicine, Tsu, Japan
    Am J Physiol Heart Circ Physiol 298:H1072-8. 2010
    b>Tenascin-C (TN-C) is an extracellular matrix glycoprotein with high bioactivity. It is expressed at low levels in normal adult heart, but upregulated under pathological conditions, such as myocardial infarction (MI). Recently, we (Ref...
  39. ncbi Topographic and zonal distribution of tenascin in human articular cartilage from femoral heads: normal versus mild and severe osteoarthritis
    K Veje
    Osteoarthritis Research Unit, Institute for Inflammation Research, Rigshospitalet National University Hospital, Copenhagen, Denmark
    Osteoarthritis Cartilage 11:217-27. 2003
    The extracellular matrix glycoprotein tenascin (TN) is upregulated in articular cartilage with severe osteoarthritis (OA)...
  40. ncbi Cell adhesion to tenascin-X mapping of cell adhesion sites and identification of integrin receptors
    F Elefteriou
    Institut de Biologie et Chimie des Proteines, CNRS, Unité Propre de Recherche 412, Universite Claude Bernard, Lyon, France
    Eur J Biochem 263:840-8. 1999
    Adhesive properties of tenascin-X (TN-X) were investigated using TN-X purified from bovine skin and recombinant proteins encompassing the RGD sequence located within the tenth fibronectin type-III domain, and the fibrinogen-like domain...
  41. ncbi Interaction between cell and extracellular matrix in heart disease: multiple roles of tenascin-C in tissue remodeling
    K Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Tsu, Japan
    Histol Histopathol 19:517-25. 2004
    ..Among various ECM molecules, tenascin-C (TNC) is well known as a regulator of multiple cellular functions during embryogenesis, wound healing or cancer ..
  42. ncbi Tenascin-C is associated with coronary plaque instability in patients with acute coronary syndromes
    Kajiwara Kenji
    Department of Molecular and Internal Medicine, Graduate School of Biochemical Sciences, Hiroshima University, Japan
    Circ J 68:198-203. 2004
    BACKGROUND: Tenascin-C (TNC) is an extracellular matrix glycoprotein that increases after inflammation and injury...
  43. ncbi Expression of tenascin-C in various human brain tumors and its relevance for survival in patients with astrocytoma
    Alexander Leins
    Institute of Neuropathology, Ludwig-Maximilians-University, Munich, Germany
    Cancer 98:2430-9. 2003
    BACKGROUND: Tenascin-C (TN-C), a large extracellular matrix (ECM) glycoprotein with a molecular weight of 180-250 kilodaltons, is present in several normal adult tissues...
  44. ncbi Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation
    Fui G Goh
    Kennedy Institute of Rheumatology Division, Imperial College of Science, Technology, and Medicine, London W6 8LH, United Kingdom
    J Immunol 184:2655-62. 2010
    ..The extracellular matrix glycoprotein tenascin-C is an endogenous activator of innate immunity that promotes the synthesis of inflammatory cytokines via ..
  45. ncbi Tenascin-C expression and its prognostic significance in oral and pharyngeal squamous cell carcinoma
    Timo Atula
    Department of Otorhinolaryngology and Head and Neck, Surgery, Helsinki University Central Hospital, PL 220, FIN 00029 HUS, Helsinki, Finland
    Anticancer Res 23:3051-6. 2003
    b>Tenascin-C (Tn-C) is an extracellular matrix protein with growth-, invasion- and angiogenesis-promoting activities...
  46. ncbi Drosophila odz gene is required for multiple cell types in the compound retina
    Yael Kinel-Tahan
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Dev Dyn 236:2541-54. 2007
    ..Disorder within each ommatidium in odz clones is accompanied by some loss of R7 precursors and visible photoreceptor precursor order...
  47. ncbi Endogenous tenascin-C enhances glioblastoma invasion with reactive change of surrounding brain tissue
    Eishu Hirata
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Cancer Sci 100:1451-9. 2009
    b>Tenascin-C is an extracellular matrix glycoprotein implicated in embryogenesis, wound healing and tumor progression. We previously revealed that tenascin-C expression is correlated with the prognosis of patients with glioblastoma...
  48. ncbi Synergistic effects of cyclic strain and Th1-like cytokines on tenascin-C production by rheumatic aortic valve interstitial cells
    L Jiang
    Department of Cardiac Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Clin Exp Immunol 155:216-23. 2009
    b>Tenascin-C (TN-C) is a key component of extracellular matrix (ECM) and its expression process is poorly understood during rheumatic heart valvular disease (RHVD)...
  49. ncbi High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies
    O Driemel
    Department of Oral and Maxillofacial Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Clin Oral Investig 11:93-9. 2007
    Tumour-invasion like wound healing is characterised by the formation of an extracellular matrix with a high tenascin-C content. The tenascin-C molecule undergoes alternative splicing...
  50. ncbi Reticular basement membrane in asthma and COPD: similar thickness, yet different composition
    Jeroen J W Liesker
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:127-35. 2009
    ..Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ...
  51. ncbi Comparative immunohistochemistry of L19 and F16 in non-small cell lung cancer and mesothelioma: two human antibodies investigated in clinical trials in patients with cancer
    Marta Pedretti
    Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Lung Cancer 64:28-33. 2009
    ..five derivatives of the human monoclonal antibodies L19 and F16, specific to splice isoforms of fibronectin and tenascin-C, are currently being investigated in clinical trials in patients with malignancies...
  52. ncbi Distribution and mRNA expression of tenascin-C in developing human lung
    R Kaarteenaho-Wiik
    Department of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland
    Am J Respir Cell Mol Biol 25:341-6. 2001
    b>Tenascin-C is an extracellular matrix glycoprotein that is spatially expressed during organogenesis, in inflammatory and fibrotic disorders, and in neoplasms...
  53. ncbi High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty: expression of tenascin C as a possible marker for inflammation
    Bin Tsukada
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Hum Pathol 40:1015-22. 2009
    ..to analyze the incidence of chronic myocarditis in dilated cardiomyopathy and to evaluate the diagnostic value of tenascin C for assessing inflammatory activity in the resected myocardium...
  54. ncbi Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator
    Florence Brellier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    FEBS Lett 585:913-20. 2011
    We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression...
  55. ncbi A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost
    David A Reardon
    Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Neuro Oncol 10:182-9. 2008
    ..S. Food and Drug Administration has approved a trial randomizing newly diagnosed GBM patients to either our study regimen or standard XRT plus temozolomide...
  56. ncbi Biological and genetic interaction between tenascin C and neuropeptide S receptor 1 in allergic diseases
    Christina Orsmark-Pietras
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    Hum Mol Genet 17:1673-82. 2008
    ..ligand for NPSR1, Neuropeptide S (NPS), activates signalling through NPSR1 and microarray analysis has identified Tenascin C (TNC) as a target gene of NPS-NPSR1 signalling. TNC has previously been implicated as a risk gene for asthma...
  57. ncbi The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling
    F S Jones
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Dev Dyn 218:235-59. 2000
    ..In contrast to many other ECM proteins, the tenascin (TN) family of glycoproteins (TN-C, TN-R, TN-W, TN-X, and TN-Y) display highly restricted and dynamic patterns of ..
  58. ncbi The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain
    Xiao Hong Zhou
    Department of Experimental Pathology, Lund University, 22185 Lund, Sweden
    Gene Expr Patterns 3:397-405. 2003
    ....
  59. ncbi Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules
    P Milev
    Department of Pharmacology, New York University Medical Center, New York 10016
    J Cell Biol 127:1703-15. 1994
    ....
  60. ncbi The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth
    D R Friedlander
    Department of Pharmacology, New York University Medical Center, New York 10016
    J Cell Biol 125:669-80. 1994
    ....
  61. ncbi Tenascin-C in development and disease: gene regulation and cell function
    P L Jones
    Pediatric Cardiology Research, Abramson Research Center, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA, 19104, USA
    Matrix Biol 19:581-96. 2000
    b>Tenascin-C (TN-C) is a modular and multifunctional extracellular matrix (ECM) glycoprotein that is exquisitely regulated during embryonic development and in adult tissue remodeling...
  62. ncbi Reverse ventricular remodelling after cardiac resynchronization therapy is associated with a reduction in serum tenascin-C and plasma matrix metalloproteinase-9 levels
    Marleen H M Hessel
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Heart Fail 9:1058-63. 2007
    ..In heart failure patients, cardiac resynchronization therapy (CRT) leads to reverse ventricular remodelling...
  63. ncbi Ehlers-Danlos syndrome due to tenascin-X deficiency: muscle weakness and contractures support overlap with collagen VI myopathies
    N C Voermans
    Am J Med Genet A 143:2215-9. 2007
  64. ncbi ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling
    Rene Chapados
    Children's Hospital of Philadelphia, PA, USA
    Circ Res 99:837-44. 2006
    b>Tenascin-C (TN-C) is an extracellular matrix (ECM) protein expressed within remodeling systemic and pulmonary arteries (PAs), where it supports vascular smooth muscle cell (SMC) proliferation...
  65. ncbi Involvement of large tenascin-C splice variants in breast cancer progression
    Takatsugu Tsunoda
    Department of Pathology, Mie University School of Medicine, Mie, Japan
    Am J Pathol 162:1857-67. 2003
    Alternative splicing of fibronectin-like type III (FNIII) repeats of tenascin-C (Tn-C) generates a number of splice variants...
  66. ncbi Time-related changes in expression of collagen types I and III and of tenascin-C in rat bone mesenchymal stem cells under co-culture with ligament fibroblasts or uniaxial stretching
    Lei Zhang
    LEMTA, Nancy University, CNRS, 2 Avenue de la Foret de Haye, BP 160, 54504 Vandoeuvre les Nancy Cedex, France
    Cell Tissue Res 332:101-9. 2008
    ..was to study the time-related changes in mRNA expression and protein levels of collagen types I and III and of tenascin-C in BMSC under co-culture with fibroblasts or under a uniaxial cyclic condition...
  67. ncbi Skin wounds and severed nerves heal normally in mice lacking tenascin-C
    E Forsberg
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Proc Natl Acad Sci U S A 93:6594-9. 1996
    A large number of functions have been demonstrated for tenascin-C by antibody perturbation assays and in vitro cell culture experiments...
  68. ncbi Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis
    B Jian
    Cardiology Research Laboratory, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA
    Am J Pathol 159:321-7. 2001
    We previously showed that the expression of tenascin (TN-C), an extracellular matrix glycoprotein found in developing bone and atherosclerotic plaque, and matrix metalloproteinase-2 (MMP-2) are coordinated and interdependent in cultured ..
  69. ncbi Vascular tenascin-C regulates cardiac endothelial phenotype and neovascularization
    Victoria L T Ballard
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    FASEB J 20:717-9. 2006
    ..pathways, in vivo bone marrow/cardiac phage display biopanning was performed and led to the identification of tenascin-C as a candidate protein...
  70. ncbi A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4
    Yohei Saito
    Department of Molecular Patho Physiology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278 8510, Japan
    J Biol Chem 282:34929-37. 2007
    b>Tenascin-C (TN-C) is unique for its cell adhesion modulatory function...
  71. ncbi Muscle characteristics and altered myofascial force transmission in tenascin-X-deficient mice, a mouse model of Ehlers-Danlos syndrome
    Peter A Huijing
    Research Instituut Move, Faculteit Bewegingswetenschappen, Vrije Universiteit, Amsterdam, The Netherlands
    J Appl Physiol 109:986-95. 2010
    The Ehlers-Danlos syndrome is a group of inherited connective tissue disorders caused by defects in collagens or tenascin-X (TNX)...
  72. ncbi Quantitative analysis of tenascin in chordae tendineae of human left ventricular papillary muscle with aging
    I Sato
    Department of Anatomy, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Ann Anat 183:443-8. 2001
    A computer image analysis was done to investigate the distribution of tenascin and collagenous matrix components (collagen types I and III) in the chordae tendineae of the anterior cusp of the left ventricular papillary muscle, using ..
  73. ncbi Regulation of tenascin-C expression by tumor necrosis factor-alpha in cultured human osteoarthritis chondrocytes
    Yutaka Nakoshi
    Department of Orthopedic Surgery and Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Mie, Japan
    J Rheumatol 35:147-52. 2008
    Expression of tenascin-C reappears in articular cartilage of persons with osteoarthritis (OA), while it is almost abolished in normal mature cartilage...
  74. ncbi Circulating tenascin-C levels in patients with idiopathic dilated cardiomyopathy
    Nobuko Aso
    Second Department of Internal Medicine, Oita University, Oita, Japan
    Am J Cardiol 94:1468-70. 2004
    Circulating serum tenascin-C (an extracellular matrix glycoprotein) levels in patients with idiopathic dilated cardiomyopathy (IDC) were measured...
  75. ncbi Identification of novel and distinct binding sites within tenascin-C for soluble and fibrillar fibronectin
    Wing S To
    Department of Matrix Biology, Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 65 Aspenlea Road, London W6 8LH, United Kingdom
    J Biol Chem 286:14881-91. 2011
    Interactions between fibronectin and tenascin-C within the extracellular matrix provide specific environmental cues that dictate tissue structure and cell function...
  76. ncbi Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure
    Naoki Fujimoto
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    J Card Fail 15:898-905. 2009
    This study investigates the predictive value of serum tenascin-C (TN-C), which is observed at the active sites of ongoing tissue remodeling, for cardiac events of patients with dilated cardiomyopathy (DCM).
  77. ncbi EGF-Like domain of tenascin-C is proapoptotic for cultured smooth muscle cells
    Kurt Wallner
    Atherosclerosis Research Center, Division of Cardiology, and Burns and Allen Research Institute, Cedars Sinai Medical Center, and UCLA School of Medicine, Los Angeles, Calif 90048, USA
    Arterioscler Thromb Vasc Biol 24:1416-21. 2004
    Based on our previous observations on the expression of Tenascin-C (Tn-C) in human atherosclerotic plaques and its colocalization with macrophages, we explored whether Tn-C undergoes fragmentation and the potential pathobiological ..
  78. ncbi Tenascin-X induces cell detachment through p38 mitogen-activated protein kinase activation
    Shinpei Fujie
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo060 0812, Japan
    Biol Pharm Bull 32:1795-9. 2009
    Extracellular matrix glycoprotein tenascin-X (TNX) is the largest member of the tenascin family...
  79. ncbi Expression of tenascin R and J1 mRNA in motoneurons after a traumatic lesion in the spinal cord
    T Lindholm
    Department of Neuroscience, , Karolinska Institutet, SE-171 77 Stockholm, Sweden
    Neuroreport 12:3513-7. 2001
    We demonstrate, using in situ hybridization, that mRNA for the anti-adhesive molecules tenascin R and J1 in the adult rat spinal motoneurons are down-regulated rapidly as a reaction after a ventral funiculus lesion...
  80. ncbi Tenascin-C may be a predictor of acute pulmonary thromboembolism
    Ahmet Celik
    Department of Cardiology, Elazig Education and Research Hospital, Elazig, Turkey
    J Atheroscler Thromb 18:487-93. 2011
    ..We found no data about the relation between tenascin-C and acute PTE in the litera-ture...
  81. ncbi Tenascin-C matrix assembly in oral squamous cell carcinoma
    D M Ramos
    Department of Stomatology, University of California, San Francisco 94143 0512, USA
    Int J Cancer 75:680-7. 1998
    We previously showed that the extracellular matrix component tenascin-C (TN-C) is upregulated in oral squamous cell carcinoma (SCC) compared with the normal oral mucosa...
  82. ncbi Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene
    M Kusakabe
    Division of Experimental Animal Research, RIKEN, Tsukuba, Japan
    J Comp Neurol 430:485-500. 2001
    ..The present study has found that expression of the extracellular matrix glycoprotein tenascin-C appears to be unaffected in astroglial cells in wild-type and R6/2 transgenic mice that express the mutant ..
  83. ncbi Immunolocalization of tenascin-C, alpha9 integrin subunit, and alphavbeta6 integrin during wound healing in human oral mucosa
    L Hakkinen
    University of British Columbia, Faculty of Dentistry, Department of Oral Biological and Medical Sciences, Vancouver, BC, Canada
    J Histochem Cytochem 48:985-98. 2000
    b>Tenascin-C (TN-C) and its isoforms are multidomain extracellular matrix (ECM) proteins that are believed to be involved in the regulation of stromal-epithelial interactions...
  84. ncbi The role of tenascin-C and related glycoproteins in early chondrogenesis
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    Microsc Res Tech 43:102-10. 1998
    A number of large multidomain extracellular matrix glycoproteins, including fibronectin and members of the tenascin and thrombospondin families, are expressed in locations that suggest they may be involved in the process of chondrogenesis...
  85. ncbi Immunohistochemical assessment of extracellular matrix components in syndrome and non-syndrome odontogenic keratocysts
    R F B Amorim
    Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Norte, Natal-RN, Brazil
    Oral Dis 10:265-70. 2004
    OBJECTIVE: Investigate the immunohistochemical distribution of fibronectin, tenascin, laminin and collagen IV in syndrome (SOKC) and non-syndrome odontogenic keratocysts (NSOKC)...
  86. ncbi In vitro immunoexpression of extracellular matrix proteins in dental pulpal and gingival human fibroblasts
    E F Martinez
    Department of Oral Pathology, Faculty of Dentistry, University of Sao Paulo, 00508 900 São Paulo, Brazil
    Int Endod J 37:749-55. 2004
    ..To compare the expression of extracellular matrix (ECM) components in human pulpal and gingival fibroblasts in vitro...
  87. ncbi Mesenchymal progenitor cells communicate via alpha and beta integrins with a three-dimensional collagen type I matrix
    Leslie Heckmann
    Department of Orthopedics, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    Cells Tissues Organs 182:143-54. 2006
    ..Expression of matrix metalloproteinase-1 was elevated irrespective of beta(1)-integrin blocking and tenascin-C was subsequently induced during gel contraction...
  88. ncbi Differential upregulation of extracellular matrix molecules associated with the appearance of granule cell dispersion and mossy fiber sprouting during epileptogenesis in a murine model of temporal lobe epilepsy
    N Heck
    LNDR, Centre de Neurochimie du CNRS, 5, rue Blaise Pascal, 67084 Strasbourg, France
    Neuroscience 129:309-24. 2004
    ..extracellular matrix (ECM) molecules in the granule cell layer of the dentate gyrus, beginning with neurocan and tenascin-C...
  89. ncbi Immunoexpression of extracellular matrix proteins in human salivary gland development
    Cristiane Furuse
    Department of Oral Pathology, , Campinas, Brazil
    Eur J Oral Sci 112:548-51. 2004
    Immunoexpression of the extracellular matrix (ECM) proteins laminin, fibronectin, tenascin and types I, III and IV collagen was analyzed in the major and minor salivary glands of seven human fetuses at different gestational ages...
  90. ncbi An immunohistochemical study of the extracellular matrix of the tarsal plate in the upper eyelid in human beings
    Stefan Milz
    Anatomische Anstalt, Ludwig Maximilians Universitat, Munich, Germany
    J Anat 206:37-45. 2005
    ..The tarsal plate immunolabelled strongly for types I, III and VI collagen and for aggrecan, versican, tenascin, cartilage oligomeric matrix protein (COMP) together with a variety of glycosaminoglycans (notably chondroitin 6 ..
  91. ncbi Effect of granulocyte macrophage-colony stimulating factor on extracellular matrix deposition by dermal fibroblasts from patients with scleroderma
    Loredana Postiglione
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita degli Studi Federico II, Naples, Italy
    J Rheumatol 32:656-64. 2005
    ....
  92. ncbi Deficiency of tenascin-X causes a decrease in the level of expression of type VI collagen
    Takeharu Minamitani
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Exp Cell Res 297:49-60. 2004
    b>Tenascin-X (TNX) is an extracellular matrix glycoprotein. We previously demonstrated that TNX-null fibroblasts exhibit decreased cell-matrix and cell-cell adhesion...
  93. ncbi Requirement for glutamine in the expression of alpha-actin and type IV collagen in mesangial cells
    Tania C Pithon-Curi
    Camilo Castelo Branco University, Sao Paulo, and Methodist University of Piracicaba FACIS, Brazil
    Cell Biochem Funct 24:217-21. 2006
    ..The specificity for the glutamine requirement is suggested by the fact that mRNA levels of tenascin were not altered by addition of glutamine...
  94. ncbi Transforming growth factor-beta-induced transition of fibroblasts: a model for myofibroblast procurement in tissue valve engineering
    Kishan Narine
    Department of Cardiac Surgery, University Hospital Ghent, Ghent, Belgium
    J Heart Valve Dis 13:281-9; discussion 289. 2004
    ..The study aim was to establish a model for efficient procurement of myofibroblasts for in-vitro seeding using fibroblasts as progenitor cells...
  95. ncbi Binding of tenascin-C to soluble fibronectin and matrix fibrils
    C Y Chung
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 270:29012-7. 1995
    The small splice variant of tenascin-C (TN) has eight fibronectin type III (FN3) domains. The major large splice variant has three (in chicken) or seven (in human) additional FN3 domains inserted between domains five and six...
  96. ncbi Immunohistochemical localisation of extracellular matrix proteins in the periodontium during cementogenesis in the rat molar
    M A Matias
    Department of Dentistry, University of Queensland, Brisbane, Australia
    Arch Oral Biol 48:709-16. 2003
    ..The aim of this study was to determine the expression of selected hard and soft tissue matrix molecules and the integrin alpha5beta1 in the periodontal tissues, during cementogenesis in the rat molar...
  97. ncbi Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm
    Maria Nataatmadja
    Department of Medicine, University of Queensland, Prince Charles Hospital, Brisbane, Australia
    Circulation 108:II329-34. 2003
    ..This study examined the relationship among the secretion of extracellular matrix proteins fibrillin, fibronectin, tenascin, and vascular smooth muscle cell (VSMC) apoptosis...
  98. ncbi Tenascin-C suppresses Rho activation
    M B Wenk
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    J Cell Biol 150:913-20. 2000
    ..b>Tenascin-C, a developmentally regulated matrix protein, modulates cellular responses to other matrix proteins, such as ..
  99. ncbi Tenascin-C blocks cell-cycle progression of anchorage-dependent fibroblasts on fibronectin through inhibition of syndecan-4
    Gertraud Orend
    Friedrich Miescher Institute for Biomedical Research, Novartis Forschungsstiftung, PO Box 2543, CH 4002 Basel, Switzerland
    Oncogene 22:3917-26. 2003
    b>Tenascin-C is an adhesion-modulatory extracellular matrix protein that is predominantly expressed during embryonic development, wound healing and in tumor stroma...
  100. ncbi Tenascin mRNA isoforms in the developing mouse brain
    U Dörries
    Department of Neurobiology, Swiss Federal Institute of Technology, Zurich
    J Neurosci Res 37:336-47. 1994
    The extracellular matrix glycoprotein tenascin is expressed in the developing mouse cerebellum as a group of four protein species of different molecular weights...
  101. ncbi Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways
    A Weinacker
    Lung Biology Center, University of California, San Francisco 94143, USA
    Am J Respir Cell Mol Biol 12:547-56. 1995
    ..The extracellular matrix protein tenascin is a ligand for both of these receptors, and fibronectin is also a ligand for alpha v beta 6...

Research Grants68

  1. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2007
    ..neutralization of a) beta1-integrin, b) L selectin, c) CD47 or d) discoidin domain receptor 1; or the addition of tenascin will markedly reduce leukocyte migration within tissue, while blocking CD44 should enhance neutrophil migration...
  2. STRUCTURAL AND BIOCHEMICAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE FUNCTION
    Samuel Bouyain; Fiscal Year: 2010
    ..is expressed predominantly on glial cells and has been associated with multiple binding partners such as tenascin-C in the extracellular matrix and contactin1 on neurons...
  3. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2003
    ..of matrix metalloproteinase-2 or TIMP-2), and anti-sense oligonuclotide for translation initiation site of tenascin mRNA (to suppress tenascin expression)...
  4. Genomic targets of oncoproteins and tumor suppressors
    Kevin Struhl; Fiscal Year: 2010
    ..Let-7 in many respects, we will perform similar mechanistic experiments to determine how miR-335 (and its targets tenascin C and Sox4 transcription factor) contributes to the process linking inflammation to cellular transformation...
  5. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2003
    ..An extracellular matrix protein, tenascin-R (TN-R) is a functional modulator of sodium channel beta and alpha subunits...
  6. MACROMOLECULAR ARRAYS IN EXTRACELLULAR MATRIX OF COCHLEA
    Vladimir Tsuprun; Fiscal Year: 2003
    ..of regularly distributed fibronectin fibrils in the basilar membrane and their association with collagen, tenascin, and other molecules will be studied...
  7. MOLECULAR ANALYSIS OF NOVEL BRAIN PROTEOGLYCANS
    Yu Yamaguchi; Fiscal Year: 1999
    ..to the fact that most other extracellular matrix components, including fibronectin, laminin, collagens, and tenascin, are not expressed or are only transiently expressed during development in the brain parenchyma...
  8. Tenascin in Chondrosarcoma Metastasis
    Sean Scully; Fiscal Year: 2004
    ..expression is an independent prognostic indicator in human chondrosarcoma; (2) we have also demonstrated that tenascin-C expression, synthesis, and matrix incorporation are distinctly different in chondrosarcoma tissue compared to ..
  9. Matrix Metalloproteinases and Regenerative Plasticity Following Brain Injury
    Linda L Phillips; Fiscal Year: 2010
    ..ECM shifts in agrin, tenascin, RPTP-2 and N-cadherin occurred during postinjury recovery as well...
  10. Matrix Metalloproteinases and Regenerative Plasticity Following Brain Injury
    Linda Phillips; Fiscal Year: 2009
    ..ECM shifts in agrin, tenascin, RPTP-2 and N-cadherin occurred during postinjury recovery as well...
  11. TENASCIN-X AND THE EHLERS-DANLOS PHENOTYPE
    James Bristow; Fiscal Year: 2002
    ..Recently, the PI's laboratory identified two unrelated patients with EDS due to deficiency of tenascin-X (TN-X), a large matrix glycoprotein...
  12. Molecular Analysis in Classical Ehlers-Danlos Syndrome
    Anna Mitchell; Fiscal Year: 2007
    ..in the COL5A1, COL5A2 (components of type V collagen), COL1A1, COL1A2 (components of type I collagen), and TNXB (tenascin X) genes resulting in the phenotype...
  13. DEVELOPMENTAL AND MOLECULAR BIOLOGY OF MECKELS CARTILAGE
    Mina Mina; Fiscal Year: 1993
    ..The influence of the ECM on differentiation of these cells will be examined. The expression of type II collagen, tenascin, fibronectin, and TGF B mRNAs by NC cells will be examined and correlated with their differentiation potential...
  14. NERVE SPROUTING AND ELECTRICAL REMODELING
    Peng Sheng Chen; Fiscal Year: 2003
    ..We will use in-situ hybridization and immunocytochemical staining to detect NGF mRNA and the tenascin proteins in a canine model of MI...
  15. A model for wrist and elbow musculoskeletal disorders
    David Rempel; Fiscal Year: 2004
    ..The antigentic location and density of structural proteins (collagen I,II, ifi, decorin, tenascin, fibronectin), and various cytokines (IL- lb...