tenascin

Summary

Summary: Hexameric extracellular matrix glycoprotein transiently expressed in many developing organs and often re-expressed in tumors. It is present in the central and peripheral nervous systems as well as in smooth muscle and tendons. (From Kreis & Vale, Guidebook to the Extracellular Matrix and Adhesion Proteins, 1993, p93)

Top Publications

  1. pmc Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
    Thordur Oskarsson
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 17:867-74. 2011
  2. doi Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    Kim Midwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Nat Med 15:774-80. 2009
  3. pmc A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment
    Dion A Daniels
    Gene Expression and Protein Biochemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, England
    Proc Natl Acad Sci U S A 100:15416-21. 2003
  4. pmc VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
    Joyce T O'Connell
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:16002-7. 2011
  5. ncbi Tenascins: regulation and putative functions during pathological stress
    Ruth Chiquet-Ehrismann
    Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Pathol 200:488-99. 2003
  6. doi The extracellular matrix glycoprotein tenascin-C promotes locomotor recovery after spinal cord injury in adult zebrafish
    Y M Yu
    W M Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, 604 Allison Road, NJ 08854, USA
    Neuroscience 183:238-50. 2011
  7. ncbi Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid
    A Laitinen
    Department of Anatomy, University of Helsinki, Finland
    Am J Respir Crit Care Med 156:951-8. 1997
  8. pmc Drosophila Ten-m and filamin affect motor neuron growth cone guidance
    Lihua Zheng
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e22956. 2011
  9. doi Expression of tenascin-C and its isoforms in the breast
    David S Guttery
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    Cancer Metastasis Rev 29:595-606. 2010
  10. ncbi Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction
    K Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Mie, Japan
    Lab Invest 81:1015-24. 2001

Research Grants

  1. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 1999
  2. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
  3. Elafin to reverse pulmonary arterial hypertension
    Marlene Rabinovitch; Fiscal Year: 2011
  4. GLIA AND GLYCOCONJUGATES IN THE NEOSTRIATUM
    Dennis Steindler; Fiscal Year: 1999
  5. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009
  6. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2007
  7. Experimental Model For Pressure Ulcers In Human Skin: The Role of Aging and ECM
    Marjana Tomic Canic; Fiscal Year: 2009
  8. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2006
  9. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2004
  10. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2005

Detail Information

Publications286 found, 100 shown here

  1. pmc Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
    Thordur Oskarsson
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 17:867-74. 2011
    ..that breast cancer cells that infiltrate the lungs support their own metastasis-initiating ability by expressing tenascin C (TNC)...
  2. doi Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    Kim Midwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Nat Med 15:774-80. 2009
    ..b>Tenascin-C (encoded by Tnc) is an extracellular matrix glycoprotein specifically expressed at areas of inflammation and ..
  3. pmc A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment
    Dion A Daniels
    Gene Expression and Protein Biochemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, England
    Proc Natl Acad Sci U S A 100:15416-21. 2003
    ..Here we characterize the interaction of the DNA aptamer, GBI-10, with tenascin-C, an extracellular protein found in the tumor matrix...
  4. pmc VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
    Joyce T O'Connell
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:16002-7. 2011
    ..with a concomitant decrease in the expression of several ECM molecules and growth factors, particularly Tenascin-C and VEGF-A...
  5. ncbi Tenascins: regulation and putative functions during pathological stress
    Ruth Chiquet-Ehrismann
    Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Pathol 200:488-99. 2003
    ..In this review, we discuss the structure and function of the extracellular matrix protein family of tenascins with emphasis on their involvement in human pathologies. The article is divided into the following sections:..
  6. doi The extracellular matrix glycoprotein tenascin-C promotes locomotor recovery after spinal cord injury in adult zebrafish
    Y M Yu
    W M Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, 604 Allison Road, NJ 08854, USA
    Neuroscience 183:238-50. 2011
    ..In the current study, the extracellular matrix glycoprotein tenascin-C was studied in the zebrafish spinal cord injury model to assess the often disparate functions of this ..
  7. ncbi Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid
    A Laitinen
    Department of Anatomy, University of Helsinki, Finland
    Am J Respir Crit Care Med 156:951-8. 1997
    b>Tenascin and fibronectin are extracellular matrix glycoproteins expressed during morphogenesis and tissue repair...
  8. pmc Drosophila Ten-m and filamin affect motor neuron growth cone guidance
    Lihua Zheng
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e22956. 2011
    The Drosophila Ten-m (also called Tenascin-major, or odd Oz (odz)) gene has been associated with a pair-rule phenotype...
  9. doi Expression of tenascin-C and its isoforms in the breast
    David S Guttery
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    Cancer Metastasis Rev 29:595-606. 2010
    b>Tenascin-C (TNC) is an extracellular matrix glycoprotein which is frequently up-regulated in a variety of pathological conditions including chronic inflammation and cancer...
  10. ncbi Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction
    K Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Mie, Japan
    Lab Invest 81:1015-24. 2001
    b>Tenascin-C (TNC), an extracellular matrix glycoprotein, plays important roles in tissue remodeling. TNC is not normally expressed in adults but reappears under pathologic conditions...
  11. ncbi The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling
    F S Jones
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Dev Dyn 218:235-59. 2000
    ..In contrast to many other ECM proteins, the tenascin (TN) family of glycoproteins (TN-C, TN-R, TN-W, TN-X, and TN-Y) display highly restricted and dynamic patterns of ..
  12. pmc Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth
    P L Jones
    Division of Cardiovascular Research, Research Institute, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Cell Biol 139:279-93. 1997
    b>Tenascin-C (TN-C) is induced in pulmonary vascular disease, where it colocalizes with proliferating smooth muscle cells (SMCs) and epidermal growth factor (EGF)...
  13. pmc The adhesion modulating properties of tenascin-W
    Florence Brellier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Int J Biol Sci 8:187-94. 2012
    Tenascins are extracellular matrix glycoproteins associated with cell motility, proliferation and differentiation. Tenascin-C inhibits cell spreading by binding to fibronectin; tenascin-R and tenascin-X also have anti-adhesive properties ..
  14. ncbi Mechanical loading regulates the expression of tenascin-C in the myotendinous junction and tendon but does not induce de novo synthesis in the skeletal muscle
    Tero A H Järvinen
    Institute of Medical Technology and Medical School, University of Tampere, Tampere, Finland
    J Cell Sci 116:857-66. 2003
    b>Tenascin-C is a hexabrachion-shaped matricellular protein with a very restricted expression in normal musculoskeletal tissues, but it is expressed abundantly during regenerative processes of these tissues and embryogenesis...
  15. ncbi The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with achilles tendon injuries
    Gaonyadiwe G Mokone
    UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, PO Box 115, Newlands 7725, South Africa
    Am J Sports Med 33:1016-21. 2005
    ..The tenascin-C gene, which has been mapped to chromosome 9q32-q34, encodes for a structural component of tendons.
  16. ncbi Expression and immune function of tenascin-C
    Irina A Udalova
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, United Kingdom
    Crit Rev Immunol 31:115-45. 2011
    ..b>Tenascin-C is a large, extracellular matrix glycoprotein that has a very tightly controlled pattern of expression...
  17. ncbi Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation
    W Huang
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Cancer Res 61:8586-94. 2001
    b>Tenascin-C is an adhesion-modulatory extracellular matrix molecule that is highly expressed in tumors...
  18. doi Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells
    Tomoki Ishigaki
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Tsu, Mie, Japan
    J Cell Physiol 226:2617-24. 2011
    ..b>Tenascin-C (TNC) is upregulated in the developing neointima of lesions...
  19. doi The extracellular matrix molecule tenascin C modulates expression levels and territories of key patterning genes during spinal cord astrocyte specification
    Michael Karus
    Department for Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, Universitatsstrasse 150, Bochum, Germany
    Development 138:5321-31. 2011
    ..Here, we demonstrate for the first time that the extracellular matrix glycoprotein tenascin C regulates the expression of key patterning genes during late embryonic spinal cord development, leading to a ..
  20. ncbi Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension
    Kaori Ihida-Stansbury
    University of Pennsylvania, Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, Philadelphia, PA 19104 6383, USA
    Am J Physiol Lung Cell Mol Physiol 291:L694-702. 2006
    ..Here we show that pulmonary vascular lesions from patients harboring BMPR2 mutations express high levels of tenascin-C (TN-C), an extracellular matrix glycoprotein that promotes pulmonary artery (PA) smooth muscle cell (SMC) ..
  21. ncbi Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrix glycoprotein tenascin-R
    A K Saghatelyan
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, Hamburg, D 20246, Germany
    Mol Cell Neurosci 17:226-40. 2001
    The role of the extracellular matrix molecule tenascin-R (TN-R) in regulation of synaptic transmission and plasticity in the CA1 region of the hippocampus was studied using mice deficient in expression of this molecule...
  22. ncbi Regulation of fibroblast migration by tenascin-C
    A Trebaul
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Biochem Soc Trans 35:695-7. 2007
    ..Excessive deposition of scar tissue is the major hallmark of fibrotic disease. Tenascin-C is an extracellular matrix glycoprotein that is transiently expressed upon tissue injury, where it is ..
  23. pmc Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population
    M Fukunaga-Kalabis
    Molecular and Cellular Oncogenesis Program, Division of Molecular and Cellular Biology, The Wistar Institute, Philadelphia, PA 19104, USA
    Oncogene 29:6115-24. 2010
    b>Tenascin-C (TNC) is highly expressed in melanoma; however, little is known about its functions. Recent studies indicate that TNC has a role within the stem cell niche...
  24. doi Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma
    Christoph Schliemann
    Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Leuk Res 33:1718-22. 2009
    ..are clinical-stage human monoclonal antibodies, which selectively recognize splice isoforms of fibronectin and tenascin-C in the modified extracellular matrix of neoplastic lesions...
  25. doi Opposite effect of fluticasone and salmeterol on fibronectin and tenascin-C expression in primary human lung fibroblasts
    M Degen
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Clin Exp Allergy 39:688-99. 2009
    ..Current therapies for asthma and COPD consist of inhaled corticosteroids and long-acting beta(2)-agonists (LABA). However, their effect on airway remodelling is not well understood so far...
  26. ncbi Tenascin-C is a useful marker for disease activity in myocarditis
    Kyoko Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Japan
    J Pathol 197:388-94. 2002
    b>Tenascin-C (TNC) is an extracellular matrix protein which appears at active sites of tissue remodelling during embryogenesis or cancer invasion...
  27. ncbi Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse
    Hiroki Nakahara
    Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu City, Japan
    Eur J Immunol 36:3334-45. 2006
    b>Tenascin C (TN-C) is an extracellular matrix glycoprotein whose expression is increased in several inflammatory diseases of the lung, including bronchial asthma...
  28. ncbi Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma
    E M Karjalainen
    Clinical Research Unit of Pulmonary Medicine, Department of Medicine, Helsinki University Central Hospital, Finland
    Respir Med 97:1045-51. 2003
    ..study was set to investigate the bronchial inflammatory cell infiltrate and subepithelial basement membrane (BM) tenascin deposition in subjects with newly diagnosed asthma and bronchial hyperresponsiveness (BHR)...
  29. pmc Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture
    Isao Kii
    Department of Biological Information, Tokyo Institute of Technology, 4259 Midori ku, Nagatsuta, Yokohama 226 8501
    J Biol Chem 285:2028-39. 2010
    ..Here we show that periostin, a matricellular protein, promotes incorporation of tenascin-C into the ECM and organizes a meshwork architecture of the ECM...
  30. ncbi Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteins
    N Dandachi
    Institute of Pathological Anatomy, Landeskliniken Salzburg, Salzburg, Austria
    J Pathol 193:181-9. 2001
    ..In human breast carcinomas, up-regulation of tenascin-C (TN-C) and vimentin (Vim) is frequently observed in cancer cells and correlates with increased malignancy...
  31. doi IGF signaling between blastema and wound epidermis is required for fin regeneration
    Fabian Chablais
    Unit of Anatomy, Department of Medicine, University of Fribourg, Rte A Gockel 1, CH 1700 Fribourg, Switzerland
    Development 137:871-9. 2010
    ..Thus, IGF signaling upregulated upon fin amputation represents a signal from the blastema to the wound epithelium, a crucial step in appendage regeneration...
  32. ncbi Mice develop normally without tenascin
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Genes Dev 6:1821-31. 1992
    b>Tenascin, an extracellular matrix protein, is expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena...
  33. pmc Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
    Ethan David Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:2538-49. 2009
    ..the effect on Pdgfr expression was, in part, mediated by direct transcriptional regulation of the ECM protein tenascin C (Tnc), which was necessary and sufficient for Pdgfralpha/beta expression in lung explants...
  34. pmc Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues
    T Oohashi
    Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 145:563-77. 1999
    ..Far Western assays and electronmicroscopy demonstrated that Ten-m1 can bind to itself...
  35. pmc Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis
    A Calvo
    Laboratory of Cancer Biology and Genetics, NCI, NIH, Bethesda, MD 20892, USA
    Oncogene 27:5373-84. 2008
    ..this set of genes with a human breast cancer lung metastasis gene signature identified five common targets: tenascin-C(TNC), matrix metalloprotease-2, collagen-6-A1, mannosidase-alpha-1A and HLA-DPA1...
  36. ncbi Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development
    Joy Lincoln
    Division of Molecular Cardiovascular Biology, MLC 7020, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 294:292-302. 2006
    ..This review will focus on the regulatory hierarchies that control normal and abnormal heart valve development in parallel with other connective tissue cell types...
  37. ncbi Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin
    Gesa Rascher
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, Germany
    Acta Neuropathol 104:85-91. 2002
    ..despite a high variability of vascular phenotypes, the loss of agrin strongly correlated with the expression of tenascin, an extracellular matrix molecule which has been described previously to be absent in mature non-pathological ..
  38. ncbi Alternative splicing in the aggrecan G3 domain influences binding interactions with tenascin-C and other extracellular matrix proteins
    Joanna M Day
    The Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 279:12511-8. 2004
    ..Here we identify tenascin-C as a ligand for the lectins of all these proteoglycans and map the binding site on the tenascin molecule to ..
  39. ncbi Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development
    A Scherberich
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Cell Sci 117:571-81. 2004
    We cloned and characterized a novel member of the tenascin family of extracellular matrix proteins--the murine orthologue of zebrafish tenascin-W. Full-length recombinant tenascin-W was expressed and purified from mammalian cell cultures...
  40. doi Endogenous activation of adaptive immunity: tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease
    Michaela Ruhmann
    Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK
    Arthritis Rheum 64:2179-90. 2012
    ..b>Tenascin-C is an arthritogenic extracellular matrix glycoprotein that is not expressed in healthy synovium but is elevated ..
  41. doi Well-defined clinical presentation of Ehlers-Danlos syndrome in patients with tenascin-X deficiency: a report of four cases
    Anke G M Hendriks
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Dysmorphol 21:15-8. 2012
    ..Shortly after the publication of these criteria in 1998, a further distinct type of EDS, the tenascin-X (TNX)-deficient type EDS, was reported...
  42. pmc Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation
    Paul Fiorilli
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
    Lab Invest 88:1143-56. 2008
    ..The H4 ECM was enriched in tenascin, a binding partner for the alpha9beta1 integrin heterodimer. Purified tenascin-C supported D283 cell adhesion...
  43. pmc Advances in tenascin-C biology
    Kim S Midwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, NDORMS, Oxford University, 65 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Cell Mol Life Sci 68:3175-99. 2011
    b>Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury...
  44. ncbi Expression of extracellular matrix components versican, chondroitin sulfate, tenascin, and hyaluronan, and their association with disease outcome in node-negative breast cancer
    Supaporn Suwiwat
    Dame Roma Mitchell Cancer Research Laboratory, Hanson Institute, Adelaide University, Adelaide, South Australia
    Clin Cancer Res 10:2491-8. 2004
    ..The purpose is to determine whether the levels of expression of extracellular matrix components in peritumoral stroma are predictive of disease outcome for women with node-negative breast cancer...
  45. pmc Enhanced tenascin expression in cervical and vulvar koilocytotic lesions
    O Tiitta
    Department of Anatomy, University of Helsinki, Finland
    Am J Pathol 141:907-13. 1992
    b>Tenascin is an extracellular matrix glycoprotein that is widely expressed during embryogenesis...
  46. pmc Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells
    Keiki Nagaharu
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Mie, Japan
    Am J Pathol 178:754-63. 2011
    b>Tenascin C (TNC) is an extracellular matrix glycoprotein up-regulated in solid tumors. Higher TNC expression is shown in invading fronts of breast cancer, which correlates with poorer patient outcome...
  47. doi Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta
    Jurgen Brinckmann
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Lab Invest 90:739-52. 2010
    ..Double labelling of fibrillin-2 and tenascin-C, which is also expressed in wound healing and sclerosis, showed co-localization of both proteins...
  48. ncbi Tenascin-W: an extracellular matrix protein associated with osteogenesis and cancer
    Enrico Martina
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Int J Biochem Cell Biol 42:1412-5. 2010
    b>Tenascin-W was the last member of a family of four large extracellular matrix glycoproteins to be discovered...
  49. ncbi Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins
    P Sriramarao
    La Jolla Institute for Experimental Medicine, CA 92037
    J Cell Sci 105:1001-12. 1993
    Human umbilical vein endothelial cells were found to attach and partially spread on human tenascin. The attachment of endothelial cells to tenascin results in elongated cells with interconnecting processes and is distinct from the ..
  50. pmc Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro
    Enrico Martina
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    FASEB J 24:778-87. 2010
    ..Among the extracellular matrix proteins enriched in the stroma of carcinomas are the tenascin family members tenascin-C and tenascin-W...
  51. doi Matrix metalloproteinase-19 deficiency promotes tenascin-C accumulation and allergen-induced airway inflammation
    Maud M Gueders
    Department of Respiratory Diseases, University of Liege and Centre Hospitalier Universitaire, Belgium
    Am J Respir Cell Mol Biol 43:286-95. 2010
    ..MMP-19 is newly described, and it preferentially cleaves matrix proteins such as collagens and tenascin-C. The role of MMP-19 in asthma has not been described to date...
  52. pmc Tenascin-C deficiency attenuates TGF-ß-mediated fibrosis following murine lung injury
    William A Carey
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Am J Physiol Lung Cell Mol Physiol 299:L785-93. 2010
    b>Tenascin-C (TNC) is an extracellular matrix glycoprotein of unknown function that is highly expressed in adult lung parenchyma following acute lung injury (ALI)...
  53. doi Immunohistochemical expression of fibronectin and tenascin in human tooth pulp capped with mineral trioxide aggregate and a novel endodontic cement
    Mohammad Hassan Zarrabi
    Department of Endodontics, School of Dentistry and Dental Research Center, University of Medical Sciences, Mashhad, and Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    J Endod 37:1613-8. 2011
    The purpose of the present study was the immunohistochemical study of fibronectin (FN) and tenascin (TN) in human tooth pulp capped with mineral trioxide aggregate (MTA) and novel endodontic cement (NEC) (calcium enriched mixture cement) ..
  54. pmc Tenascin-C suppresses Rho activation
    M B Wenk
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    J Cell Biol 150:913-20. 2000
    ..b>Tenascin-C, a developmentally regulated matrix protein, modulates cellular responses to other matrix proteins, such as ..
  55. pmc The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C
    B Varnum-Finney
    Department of Physiology, University of California, San Francisco 94143 0724, USA
    Neuron 14:1213-22. 1995
    This paper identifies a neuronal receptor for tenascin-C (tenascin/cytotactin), an extracellular matrix protein that has previously been detected in developing sensory and motor neuron pathways and has been shown to regulate cell ..
  56. pmc Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions
    E Aufderheide
    Friederich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    J Cell Biol 107:2341-9. 1988
    b>Tenascin, an extracellular matrix protein, is expressed in the mesenchyme around growing epithelia in the embryo. We therefore investigated whether epithelial cells can stimulate expression of tenascin in embryonic mesenchyme...
  57. ncbi Relevance of tenascin-C and matrix metalloproteinases in vascular abnormalities in murine hypoplastic lungs
    Mala R Chinoy
    Lung Development Research Program, Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biol Neonate 90:185-96. 2006
    b>Tenascin-C (TN-C), an extracellular matrix glycoprotein, is crucial to cell-migration, proliferation, apoptosis and remodeling of tissues, with a potential role in pathobiology of pulmonary hypertension...
  58. ncbi Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro
    Arnaud Scherberich
    Novartis Research Foundation, Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Oncogene 24:1525-32. 2005
    ..Here we have analyzed the most recently described member, tenascin-W, in breast cancer...
  59. ncbi Severe cognitive and motor coordination deficits in tenascin-R-deficient mice
    M Montag-Sallaz
    Neurogenetics Research Group, Leibniz Institute for Neurobiology, Brenneckestr, Magdeburg, Germany
    Genes Brain Behav 2:20-31. 2003
    The extracellular matrix molecule tenascin-R (TN-R), predominantly expressed in the central nervous system, has been implied in a variety of functions, e.g...
  60. pmc The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration
    Jian Chen
    W M Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience, Rutgers The State University of New Jersey, Piscataway, New Jersey, USA
    Mol Ther 18:1769-77. 2010
    b>Tenascin-C (TNC), a major component of the extracellular matrix, is strongly upregulated after injuries of the central nervous system (CNS) but its role in tissue repair is not understood...
  61. ncbi Impairment of L-type Ca2+ channel-dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin-C
    Matthias R Evers
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    J Neurosci 22:7177-94. 2002
    The extracellular matrix glycoprotein tenascin-C (TN-C) has been suggested to play important functional roles during neural development, axonal regeneration, and synaptic plasticity...
  62. pmc Regeneration of the perineurium after microsurgical resection examined with immunolabeling for tenascin-C and alpha smooth muscle actin
    Michiro Yamamoto
    Department of Hand Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Anat 218:413-25. 2011
    ..Our hypothesis is that the regenerative process of the perineurium can be demonstrated by immunolabeling for tenascin-C and alpha smooth muscle actin after microsurgical resection of the perineurium in vivo...
  63. ncbi Expression of tenascin in developing and adult mouse lymphoid organs
    G Ocklind
    Department of Zoophysiology, Uppsala University, Sweden
    J Histochem Cytochem 41:1163-9. 1993
    ..b>Tenascin is a hexameric glycoprotein of the ECM...
  64. pmc Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells
    Annalisa Pezzolo
    Laboratory of Oncology, Istituto Giannina Gaslini, Largo G Gaslini 5, 16147 Genova Quarto, Italy
    Cell Res 21:1470-86. 2011
    ..Oct-4(+) cells expressed stem cell-related, neural progenitor-related and NB-related markers, including surface Tenascin C (TNC), that was absent from perinecrotic Oct-4(+) cells and bulk tumor cells...
  65. ncbi The structure and function of tenascins in the nervous system
    A Joester
    Department of Neurobiology, Im Neuenheimer Feld 364, D 69120, Heidelberg, Germany
    Matrix Biol 20:13-22. 2001
    ..Three of these, tenascin-C (TN-C) tenascin-R (TN-R) and tenascin-Y (TN-Y) are expressed in specific patterns during nervous system ..
  66. ncbi Odd Oz: a novel Drosophila pair rule gene
    A Levine
    Department of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Cell 77:587-98. 1994
    ..Instead, it encodes a protein with EGF-like repeats homologous to those of the extracellular matrix protein tenascin. The protein is also a putative transmembrane tyrosine kinase substrate...
  67. pmc Regulation of tenascin expression in bone
    Jessica M Morgan
    Department of Anatomy, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    J Cell Biochem 112:3354-63. 2011
    ..C and W influence osteoblast adhesion and differentiation, although little is known about the regulation of tenascin expression...
  68. ncbi Tenascin expression and distribution in pleural inflammatory and fibrotic diseases
    R Kaarteenaho-Wiik
    Department of Pathology, University of Oulu, Oulu, Finland
    J Histochem Cytochem 48:1257-68. 2000
    We hypothesized that tenascin expression is increased in pleural inflammatory and fibrotic diseases and that its expression can be used as a marker of active pleural involvement...
  69. ncbi Distribution pattern of tenascin-C in glioblastoma: correlation with angiogenesis and tumor cell proliferation
    Senija Behrem
    Department of Pathology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    Pathol Oncol Res 11:229-35. 2005
    b>Tenascin-C (TN-C) is an extracellular matrix protein which participates in different processes like normal fetal development, wound healing, inflammation, keloids and rheumatoid arthritis...
  70. doi Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration
    Melissa R Andrews
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 2PY, United Kingdom
    J Neurosci 29:5546-57. 2009
    ..They also lack an integrin that interacts with tenascin-C, the main extracellular matrix glycoprotein of the CNS, which is upregulated after injury...
  71. doi Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension
    Jorge Correia-Pinto
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho, Braga, Portugal
    Basic Res Cardiol 104:535-45. 2009
    ..Cardiomyocyte apoptosis was evaluated by TUNEL assay. Extracellular matrix composition was evaluated by tenascin-C mRNA levels and interstitial collagen content...
  72. ncbi Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization
    Katrin Lange
    Center for Biomedicine, Department of Clinical and Biological Sciences, University of Basel, Basel, Switzerland
    Cancer Res 67:6163-73. 2007
    b>Tenascin-C, an extracellular matrix molecule of the tumor-specific microenvironment, counteracts the tumor cell proliferation-suppressing effect of fibronectin by blocking the integrin alpha(5)beta(1)/syndecan-4 complex...
  73. doi From mechanotransduction to extracellular matrix gene expression in fibroblasts
    Matthias Chiquet
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Biochim Biophys Acta 1793:911-20. 2009
    ..actin dynamics directly to the expression of specific genes, among them the extracellular matrix protein tenascin-C...
  74. doi A multimodal nanoparticle-based cancer imaging probe simultaneously targeting nucleolin, integrin αvβ3 and tenascin-C proteins
    Hae Young Ko
    Laboratory of Molecular Imaging, Department of Applied Bioscience, CHA Stem Cell Institute, CHA University, 605 21 Yoeksam 1 dong, Gangnam Gu, Seoul 135 081, Republic of Korea
    Biomaterials 32:1130-8. 2011
    ..The results demonstrated that the SMART cancer probe will be useful for the diagnosis of different cancers as a cancer master probe...
  75. ncbi Expression of N-cadherin, N-CAM, fibronectin and tenascin is stimulated by TGF-beta1, beta2, beta3 and beta5 during the formation of precartilage condensations
    J Chimal-Monroy
    Department of Cell Biology, Instituto de Investigaciones Biomedicas, UNAM, Mexico D F, Mexico
    Int J Dev Biol 43:59-67. 1999
    ..relationship between adhesion molecules (N-cadherin and N-CAM), extracellular matrix proteins (fibronectin and tenascin) and TGF-beta1, TGF-beta2 and TGF-beta3 during in vitro precartilage condensations in mouse chondrogenesis...
  76. ncbi Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Circ J 71:327-30. 2007
    b>Tenascin-C (TN-C), an extracellular matrix glycoprotein, is specifically expressed at high levels during embryonic development, but not in the adult heart...
  77. doi Polymorphism and expression of the porcine Tenascin C gene associated with meat and carcass quality
    A Kayan
    Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany
    Meat Sci 89:76-83. 2011
    The research aimed to screen for polymorphism, expression of Tenascin C (TNC) and association with meat and carcass quality traits. Three single nucleotide polymorphisms were detected. In a Duroc×Pietrain F2 cross (DuPi) population, g...
  78. ncbi Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains
    Y Yokosaki
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Biol Chem 271:24144-50. 1996
    ..For example, at least 5 different integrins recognize tenascin as a ligand, and 4 of these bind to the same region of the protein, the third fibronectin type III repeat (TNfn3)...
  79. ncbi Endogenous tenascin-C enhances glioblastoma invasion with reactive change of surrounding brain tissue
    Eishu Hirata
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Cancer Sci 100:1451-9. 2009
    b>Tenascin-C is an extracellular matrix glycoprotein implicated in embryogenesis, wound healing and tumor progression. We previously revealed that tenascin-C expression is correlated with the prognosis of patients with glioblastoma...
  80. doi Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice
    Tomohiro Nishioka
    Dept of Pathology and Matrix Biology, Mie Univ Graduate School of Medicine, Tsu, Japan
    Am J Physiol Heart Circ Physiol 298:H1072-8. 2010
    b>Tenascin-C (TN-C) is an extracellular matrix glycoprotein with high bioactivity. It is expressed at low levels in normal adult heart, but upregulated under pathological conditions, such as myocardial infarction (MI). Recently, we (Ref...
  81. ncbi Topographic and zonal distribution of tenascin in human articular cartilage from femoral heads: normal versus mild and severe osteoarthritis
    K Veje
    Osteoarthritis Research Unit, Institute for Inflammation Research, Rigshospitalet National University Hospital, Copenhagen, Denmark
    Osteoarthritis Cartilage 11:217-27. 2003
    The extracellular matrix glycoprotein tenascin (TN) is upregulated in articular cartilage with severe osteoarthritis (OA)...
  82. pmc Suppression subtractive hybridization identifies distinctive expression markers for coronary and internal mammary arteries
    Minghui Qin
    Atherosclerosis Research Center, Division of Cardiology, and Burns and Allen Research Institute, Cedars Sinai Medical Center, Davis Bldg 1016, 8700 Beverly Blvd, Los Angeles, Calif 90048, USA
    Arterioscler Thromb Vasc Biol 23:425-33. 2003
    ..We sought to identify differentially expressed genes in the athero-prone coronary artery and athero-resistant internal mammary arteries...
  83. doi Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation
    Fui G Goh
    Kennedy Institute of Rheumatology Division, Imperial College of Science, Technology, and Medicine, London W6 8LH, United Kingdom
    J Immunol 184:2655-62. 2010
    ..The extracellular matrix glycoprotein tenascin-C is an endogenous activator of innate immunity that promotes the synthesis of inflammatory cytokines via ..
  84. doi Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator
    Florence Brellier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    FEBS Lett 585:913-20. 2011
    We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression...
  85. ncbi Tenascin-C expression and its prognostic significance in oral and pharyngeal squamous cell carcinoma
    Timo Atula
    Department of Otorhinolaryngology and Head and Neck, Surgery, Helsinki University Central Hospital, PL 220, FIN 00029 HUS, Helsinki, Finland
    Anticancer Res 23:3051-6. 2003
    b>Tenascin-C (Tn-C) is an extracellular matrix protein with growth-, invasion- and angiogenesis-promoting activities...
  86. pmc Reticular basement membrane in asthma and COPD: similar thickness, yet different composition
    Jeroen J W Liesker
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:127-35. 2009
    ..Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ...
  87. ncbi Expression of tenascin-C in various human brain tumors and its relevance for survival in patients with astrocytoma
    Alexander Leins
    Institute of Neuropathology, Ludwig Maximilians University, Munich, Germany
    Cancer 98:2430-9. 2003
    b>Tenascin-C (TN-C), a large extracellular matrix (ECM) glycoprotein with a molecular weight of 180-250 kilodaltons, is present in several normal adult tissues...
  88. ncbi Role of RhoA/ROCK-dependent actin contractility in the induction of tenascin-C by cyclic tensile strain
    Ana Sarasa-Renedo
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, P O Box 54, Switzerland
    Exp Cell Res 312:1361-70. 2006
    In chick embryo fibroblasts, the mRNA for extracellular matrix protein tenascin-C is induced 2-fold by cyclic strain (10%, 0.3 Hz, 6 h). This response is attenuated by inhibiting Rho-dependent kinase (ROCK)...
  89. doi High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty: expression of tenascin C as a possible marker for inflammation
    Bin Tsukada
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Hum Pathol 40:1015-22. 2009
    ..to analyze the incidence of chronic myocarditis in dilated cardiomyopathy and to evaluate the diagnostic value of tenascin C for assessing inflammatory activity in the resected myocardium...
  90. ncbi Drosophila odz gene is required for multiple cell types in the compound retina
    Yael Kinel-Tahan
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Dev Dyn 236:2541-54. 2007
    ..Disorder within each ommatidium in odz clones is accompanied by some loss of R7 precursors and visible photoreceptor precursor order...
  91. pmc A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost
    David A Reardon
    Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Neuro Oncol 10:182-9. 2008
    ..S. Food and Drug Administration has approved a trial randomizing newly diagnosed GBM patients to either our study regimen or standard XRT plus temozolomide...
  92. doi Comparative immunohistochemistry of L19 and F16 in non-small cell lung cancer and mesothelioma: two human antibodies investigated in clinical trials in patients with cancer
    Marta Pedretti
    Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Lung Cancer 64:28-33. 2009
    ..five derivatives of the human monoclonal antibodies L19 and F16, specific to splice isoforms of fibronectin and tenascin-C, are currently being investigated in clinical trials in patients with malignancies...
  93. pmc Synergistic effects of cyclic strain and Th1-like cytokines on tenascin-C production by rheumatic aortic valve interstitial cells
    L Jiang
    Department of Cardiac Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Clin Exp Immunol 155:216-23. 2009
    b>Tenascin-C (TN-C) is a key component of extracellular matrix (ECM) and its expression process is poorly understood during rheumatic heart valvular disease (RHVD)...
  94. ncbi Interaction between cell and extracellular matrix in heart disease: multiple roles of tenascin-C in tissue remodeling
    K Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Tsu, Japan
    Histol Histopathol 19:517-25. 2004
    ..Among various ECM molecules, tenascin-C (TNC) is well known as a regulator of multiple cellular functions during embryogenesis, wound healing or cancer ..
  95. ncbi Tenascin-C is associated with coronary plaque instability in patients with acute coronary syndromes
    Kajiwara Kenji
    Department of Molecular and Internal Medicine, Graduate School of Biochemical Sciences, Hiroshima University, Japan
    Circ J 68:198-203. 2004
    b>Tenascin-C (TNC) is an extracellular matrix glycoprotein that increases after inflammation and injury...
  96. ncbi High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies
    O Driemel
    Department of Oral and Maxillofacial Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Clin Oral Investig 11:93-9. 2007
    Tumour-invasion like wound healing is characterised by the formation of an extracellular matrix with a high tenascin-C content. The tenascin-C molecule undergoes alternative splicing...
  97. ncbi Tenascin-C is involved in motor axon outgrowth in the trunk of developing zebrafish
    Jörn Schweitzer
    Zentrum für Molekulare Neurobiologie, Hamburg, Germany
    Dev Dyn 234:550-66. 2005
    ..b>Tenascin-C, a component of the extracellular matrix, is concentrated in this choice region...
  98. ncbi Distribution and mRNA expression of tenascin-C in developing human lung
    R Kaarteenaho-Wiik
    Department of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland
    Am J Respir Cell Mol Biol 25:341-6. 2001
    b>Tenascin-C is an extracellular matrix glycoprotein that is spatially expressed during organogenesis, in inflammatory and fibrotic disorders, and in neoplasms...
  99. pmc Cell-adhesive responses to tenascin-C splice variants involve formation of fascin microspikes
    D Fischer
    Friedrich Miescher Institut, Basel, Switzerland
    Mol Biol Cell 8:2055-75. 1997
    b>Tenascin-C is an adhesion-modulating matrix glycoprotein that has multiple effects on cell behavior...
  100. ncbi Cell adhesion to tenascin-X mapping of cell adhesion sites and identification of integrin receptors
    F Elefteriou
    Institut de Biologie et Chimie des Proteines, CNRS, Unité Propre de Recherche 412, Universite Claude Bernard, Lyon, France
    Eur J Biochem 263:840-8. 1999
    Adhesive properties of tenascin-X (TN-X) were investigated using TN-X purified from bovine skin and recombinant proteins encompassing the RGD sequence located within the tenth fibronectin type-III domain, and the fibrinogen-like domain...
  101. ncbi Teneurins: a conserved family of transmembrane proteins involved in intercellular signaling during development
    R P Tucker
    Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616, USA
    Dev Biol 290:237-45. 2006
    ..Teneurin function appears to be required for a fundamentally important signaling mechanism conserved between invertebrates and vertebrates having an impact on many processes relying on cell-cell contact throughout development...

Research Grants69

  1. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 1999
    ..bind specifically and with high affinity to neural cell adhesion molecules and the extracellular matrix protein tenascin. It is now planned to explore the roles of neurocan and phosphacan in neurobiological processes using both ..
  2. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..bind specifically and with high affinity to neural cell adhesion molecules and the extracellular matrix protein tenascin. It is now planned to explore the roles of neurocan and phosphacan in neurobiological processes using both ..
  3. Elafin to reverse pulmonary arterial hypertension
    Marlene Rabinovitch; Fiscal Year: 2011
    ..Further studies showed that elastase activation of matrix metalloproteinases (MMPs), upregulates tenascin-C, leading to the clustering and activation of growth factor receptors (17) that further promote proliferation of ..
  4. GLIA AND GLYCOCONJUGATES IN THE NEOSTRIATUM
    Dennis Steindler; Fiscal Year: 1999
    ..circuit during development and in the adult, and antibody perturbation experiments versus studies on a tenascin-knockout mouse will provide complementary data on possible functions of particular ECM boundary molecules on ..
  5. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009
    ..and Col2a1;interzone cells, Gdf5;early articular chondrocytes, Pg4 (lubricin) and mature articular cells, tnc (tenascin c) and Col2a1...
  6. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2007
    ..neutralization of a) beta1-integrin, b) L selectin, c) CD47 or d) discoidin domain receptor 1; or the addition of tenascin will markedly reduce leukocyte migration within tissue, while blocking CD44 should enhance neutrophil migration...
  7. Experimental Model For Pressure Ulcers In Human Skin: The Role of Aging and ECM
    Marjana Tomic Canic; Fiscal Year: 2009
    ..in skin specimens in the absence or presence of compressive load: 1) extra cellular matrix (ECM) properties (tenascin, fibronectin, elastin, procollagen, collagen, matrix metalloproteinases (MMP)) and its signaling (integrins, FAK ..
  8. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2006
    ..neutralization of a) beta1-integrin, b) L selectin, c) CD47 or d) discoidin domain receptor 1; or the addition of tenascin will markedly reduce leukocyte migration within tissue, while blocking CD44 should enhance neutrophil migration...
  9. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2004
    ..neutralization of a) beta1-integrin, b) L selectin, c) CD47 or d) discoidin domain receptor 1; or the addition of tenascin will markedly reduce leukocyte migration within tissue, while blocking CD44 should enhance neutrophil migration...
  10. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2005
    ..neutralization of a) beta1-integrin, b) L selectin, c) CD47 or d) discoidin domain receptor 1; or the addition of tenascin will markedly reduce leukocyte migration within tissue, while blocking CD44 should enhance neutrophil migration...
  11. STRUCTURAL AND BIOCHEMICAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE FUNCTION
    Samuel Bouyain; Fiscal Year: 2010
    ..is expressed predominantly on glial cells and has been associated with multiple binding partners such as tenascin-C in the extracellular matrix and contactin1 on neurons...
  12. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2000
    ..of matrix metalloproteinase-2 or TIMP-2), and anti-sense oligonuclotide for translation initiation site of tenascin mRNA (to suppress tenascin expression)...
  13. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2001
    ..of matrix metalloproteinase-2 or TIMP-2), and anti-sense oligonuclotide for translation initiation site of tenascin mRNA (to suppress tenascin expression)...
  14. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2003
    ..of matrix metalloproteinase-2 or TIMP-2), and anti-sense oligonuclotide for translation initiation site of tenascin mRNA (to suppress tenascin expression)...
  15. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2002
    ..of matrix metalloproteinase-2 or TIMP-2), and anti-sense oligonuclotide for translation initiation site of tenascin mRNA (to suppress tenascin expression)...
  16. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2001
    ..An extracellular matrix protein, tenascin-R (TN-R) is a functional modulator of sodium channel beta and alpha subunits...
  17. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2000
    ..An extracellular matrix protein, tenascin-R (TN-R) is a functional modulator of sodium channel beta and alpha subunits...
  18. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2002
    ..An extracellular matrix protein, tenascin-R (TN-R) is a functional modulator of sodium channel beta and alpha subunits...
  19. FUNCTIONAL MODULATION OF SODIUM CHANNELS BY TENASCIN-R
    LORI ISOM; Fiscal Year: 2003
    ..An extracellular matrix protein, tenascin-R (TN-R) is a functional modulator of sodium channel beta and alpha subunits...
  20. Genomic targets of oncoproteins and tumor suppressors
    Kevin Struhl; Fiscal Year: 2010
    ..Let-7 in many respects, we will perform similar mechanistic experiments to determine how miR-335 (and its targets tenascin C and Sox4 transcription factor) contributes to the process linking inflammation to cellular transformation...
  21. MACROMOLECULAR ARRAYS IN EXTRACELLULAR MATRIX OF COCHLEA
    Vladimir Tsuprun; Fiscal Year: 2003
    ..of regularly distributed fibronectin fibrils in the basilar membrane and their association with collagen, tenascin, and other molecules will be studied...
  22. MACROMOLECULAR ARRAYS IN EXTRACELLULAR MATRIX OF COCHLEA
    Vladimir Tsuprun; Fiscal Year: 2001
    ..of regularly distributed fibronectin fibrils in the basilar membrane and their association with collagen, tenascin, and other molecules will be studied...
  23. ALPHA GAMMA INTEGRINS IN ORAL CANCER
    Robert Pytela; Fiscal Year: 2000
    ..Integrins interact with extracellular matrix proteins such as fibronectin, vitronectin, tenascin, collagen, and laminin and transmit signals that regulate gene expression, cell proliferation, survival...
  24. MACROMOLECULAR ARRAYS IN EXTRACELLULAR MATRIX OF COCHLEA
    Vladimir Tsuprun; Fiscal Year: 2002
    ..of regularly distributed fibronectin fibrils in the basilar membrane and their association with collagen, tenascin, and other molecules will be studied...
  25. Tenascin in Chondrosarcoma Metastasis
    Sean Scully; Fiscal Year: 2004
    ..expression is an independent prognostic indicator in human chondrosarcoma; (2) we have also demonstrated that tenascin-C expression, synthesis, and matrix incorporation are distinctly different in chondrosarcoma tissue compared to ..
  26. Tenascin in Chondrosarcoma Metastasis
    Sean Scully; Fiscal Year: 2002
    ..expression is an independent prognostic indicator in human chondrosarcoma; (2) we have also demonstrated that tenascin-C expression, synthesis, and matrix incorporation are distinctly different in chondrosarcoma tissue compared to ..
  27. MOLECULAR ANALYSIS OF NOVEL BRAIN PROTEOGLYCANS
    Yu Yamaguchi; Fiscal Year: 1999
    ..to the fact that most other extracellular matrix components, including fibronectin, laminin, collagens, and tenascin, are not expressed or are only transiently expressed during development in the brain parenchyma...
  28. Tenascin in Chondrosarcoma Metastasis
    Sean Scully; Fiscal Year: 2003
    ..expression is an independent prognostic indicator in human chondrosarcoma; (2) we have also demonstrated that tenascin-C expression, synthesis, and matrix incorporation are distinctly different in chondrosarcoma tissue compared to ..
  29. Matrix Metalloproteinases and Regenerative Plasticity Following Brain Injury
    Linda Phillips; Fiscal Year: 2009
    ..ECM shifts in agrin, tenascin, RPTP-2 and N-cadherin occurred during postinjury recovery as well...
  30. Matrix Metalloproteinases and Regenerative Plasticity Following Brain Injury
    Linda Phillips; Fiscal Year: 2009
    ..ECM shifts in agrin, tenascin, RPTP-2 and N-cadherin occurred during postinjury recovery as well...
  31. Matrix Metalloproteinases and Regenerative Plasticity Following Brain Injury
    Linda L Phillips; Fiscal Year: 2010
    ..ECM shifts in agrin, tenascin, RPTP-2 and N-cadherin occurred during postinjury recovery as well...
  32. HOMEOBOX GENES AND CONGENITAL MALFORMATION OF THE LUNG
    MaryAnn Volpe; Fiscal Year: 2001
    ..expression of molecules involved in cell adhesion (E-Cadherin, integrin) and cell-matrix interactions (laminin, tenascin) will be studied using quantitative competitive polymerase chain reaction (QC-PCR), in situ hybridization, ..
  33. NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
    FIROZE JUNGALWALA; Fiscal Year: 1991
    ..important glycoproteins involved in cellular interaction, such as neural cell adhesion molecules, N_CAMs, L1, J1, tenascin, cytotactin, integrin, NILE, myelin associated glycoprotein and PO protein...
  34. THROMBOSPONDIN AND TENASCIN--CELL ADHESION REGULATORS
    Joanne Murphy Ullrich; Fiscal Year: 1990
    ..Studies by myself and others indicate that thrombospondin (TSP) and tenascin (TN) are two such ECM molecules which destabilize cell adhesion...
  35. GLYCOPROTEIN MARKERS OF UTERINE RECEPTIVITY
    Daniel Carson; Fiscal Year: 1993
    ..Finally, other experiments indicate that tenascin (TN), an extracellular matrix glycoprotein which appears to disrupt cell adhesion events and may bind growth ..
  36. TENASCIN-X AND THE EHLERS-DANLOS PHENOTYPE
    James Bristow; Fiscal Year: 2000
    ..Recently, the PI's laboratory identified two unrelated patients with EDS due to deficiency of tenascin-X (TN-X), a large matrix glycoprotein...
  37. TENASCIN-X AND THE EHLERS-DANLOS PHENOTYPE
    James Bristow; Fiscal Year: 2002
    ..Recently, the PI's laboratory identified two unrelated patients with EDS due to deficiency of tenascin-X (TN-X), a large matrix glycoprotein...
  38. TENASCIN-X AND THE EHLERS-DANLOS PHENOTYPE
    James Bristow; Fiscal Year: 2001
    ..Recently, the PI's laboratory identified two unrelated patients with EDS due to deficiency of tenascin-X (TN-X), a large matrix glycoprotein...
  39. Molecular Analysis in Classical Ehlers-Danlos Syndrome
    Anna Mitchell; Fiscal Year: 2006
    ..in the COL5A1, COL5A2 (components of type V collagen), COL1A1, COL1A2 (components of type I collagen), and TNXB (tenascin X) genes resulting in the phenotype...
  40. Molecular Analysis in Classical Ehlers-Danlos Syndrome
    Anna Mitchell; Fiscal Year: 2004
    ..in the COL5A1, COL5A2 (components of type V collagen), COL1A1, COL1A2 (components of type I collagen), and TNXB (tenascin X) genes resulting in the phenotype...
  41. Molecular Analysis in Classical Ehlers-Danlos Syndrome
    Anna Mitchell; Fiscal Year: 2007
    ..in the COL5A1, COL5A2 (components of type V collagen), COL1A1, COL1A2 (components of type I collagen), and TNXB (tenascin X) genes resulting in the phenotype...
  42. DEVELOPMENTAL AND MOLECULAR BIOLOGY OF MECKELS CARTILAGE
    Mina Mina; Fiscal Year: 1991
    ..The influence of the ECM on differentiation of these cells will be examined. The expression of type II collagen, tenascin, fibronectin, and TGF B mRNAs by NC cells will be examined and correlated with their differentiation potential...
  43. Molecular Analysis in Classical Ehlers-Danlos Syndrome
    Anna Mitchell; Fiscal Year: 2009
    ..in the COL5A1, COL5A2 (components of type V collagen), COL1A1, COL1A2 (components of type I collagen), and TNXB (tenascin X) genes resulting in the phenotype...
  44. DEVELOPMENTAL AND MOLECULAR BIOLOGY OF MECKELS CARTILAGE
    Mina Mina; Fiscal Year: 1993
    ..The influence of the ECM on differentiation of these cells will be examined. The expression of type II collagen, tenascin, fibronectin, and TGF B mRNAs by NC cells will be examined and correlated with their differentiation potential...
  45. DEVELOPMENTAL AND MOLECULAR BIOLOGY OF MECKELS CARTILAGE
    Mina Mina; Fiscal Year: 1992
    ..The influence of the ECM on differentiation of these cells will be examined. The expression of type II collagen, tenascin, fibronectin, and TGF B mRNAs by NC cells will be examined and correlated with their differentiation potential...
  46. GROWTH FACTOR INDUCED TENASCIN C IN DIABETIC RETINOPATHY
    Alexander Ljubimov; Fiscal Year: 2000
    ..The hypothesis to be tested is that vascular endothelial growth factor stimulates endothelial cell tenascin-C expression and its deposition in retinal neovascular basement membrane...
  47. GROWTH FACTOR INDUCED TENASCIN C IN DIABETIC RETINOPATHY
    Alexander Ljubimov; Fiscal Year: 1999
    ..The hypothesis to be tested is that vascular endothelial growth factor stimulates endothelial cell tenascin-C expression and its deposition in retinal neovascular basement membrane...
  48. NERVE SPROUTING AND ELECTRICAL REMODELING
    Peng Sheng Chen; Fiscal Year: 2000
    ..We will use in-situ hybridization and immunocytochemical staining to detect NGF mRNA and the tenascin proteins in a canine model of MI...
  49. NERVE SPROUTING AND ELECTRICAL REMODELING
    Peng Sheng Chen; Fiscal Year: 2001
    ..We will use in-situ hybridization and immunocytochemical staining to detect NGF mRNA and the tenascin proteins in a canine model of MI...
  50. NERVE SPROUTING AND ELECTRICAL REMODELING
    Peng Sheng Chen; Fiscal Year: 2003
    ..We will use in-situ hybridization and immunocytochemical staining to detect NGF mRNA and the tenascin proteins in a canine model of MI...
  51. Intrathecal Cancer Therapy using I131 NaI
    Franklin Wong; Fiscal Year: 2001
    ..Others using tumor-specific I-131 labeled anti-tenascin monoclonal antibodies have found partial therapeutic success but encountered hematotoxicity...
  52. INTEGRIN DISTRIBUTION AND FUNCTION IN TUMOR CELLS
    Robert Pytela; Fiscal Year: 1991
    ..integrins recognize extracellular matrix ligands, including fibronectin, laminin, collagens, vitronectin, and tenascin. Some integrins mediate cell-cell interactions by binding to other membrane proteins, like I-CAM...
  53. Intrathecal Cancer Therapy using I131 NaI
    Franklin Wong; Fiscal Year: 2002
    ..Others using tumor-specific I-131 labeled anti-tenascin monoclonal antibodies have found partial therapeutic success but encountered hematotoxicity...
  54. NERVE SPROUTING AND ELECTRICAL REMODELING
    Peng Sheng Chen; Fiscal Year: 2002
    ..We will use in-situ hybridization and immunocytochemical staining to detect NGF mRNA and the tenascin proteins in a canine model of MI...
  55. FUNCTION OF A NOVEL AIRWAY EPITHELIAL ADHESION RECEPTOR
    Dean Sheppard; Fiscal Year: 1999
    The integrin alpha/v/beta6, a receptor for the extracellular matrix proteins fibronectin and tenascin, is highly expressed in both airway and alveolar epithelium during organogenesis and in response to injury or inflammation...
  56. A model for wrist and elbow musculoskeletal disorders
    David Rempel; Fiscal Year: 2003
    ..The antigentic location and density of structural proteins (collagen I,II, ifi, decorin, tenascin, fibronectin), and various cytokines (IL- lb...
  57. A model for wrist and elbow musculoskeletal disorders
    David Rempel; Fiscal Year: 2002
    ..The antigentic location and density of structural proteins (collagen I,II, ifi, decorin, tenascin, fibronectin), and various cytokines (IL- lb...
  58. PG-NG2 AND BIOLOGY OF 02A GLIAL PROGENITOR CELLS
    William Stallcup; Fiscal Year: 2000
    ..Extracellular matrix-associated ligands for NG2 include type VI collagen, thrombospondin, tenascin, and laminin, while membrane associated ligands include the PDGF alpha receptor...
  59. PG-NG2 AND BIOLOGY OF 02A GLIAL PROGENITOR CELLS
    William Stallcup; Fiscal Year: 1999
    ..Extracellular matrix-associated ligands for NG2 include type VI collagen, thrombospondin, tenascin, and laminin, while membrane associated ligands include the PDGF alpha receptor...
  60. A model for wrist and elbow musculoskeletal disorders
    David Rempel; Fiscal Year: 2001
    ..The antigentic location and density of structural proteins (collagen I,II, ifi, decorin, tenascin, fibronectin), and various cytokines (IL- lb...
  61. A model for wrist and elbow musculoskeletal disorders
    David Rempel; Fiscal Year: 2004
    ..The antigentic location and density of structural proteins (collagen I,II, ifi, decorin, tenascin, fibronectin), and various cytokines (IL- lb...
  62. BRAIN EXTRACELLULAR MATRIX--ROLES IN NEURAL FUNCTION AND
    Yu Yamaguchi; Fiscal Year: 1999
    ..Dr. Yamaguchi's studies revealed that brevican (and also other lecticans) binds tenascin-R, a nervous system-specific ECM protein, through its C-type lectin domain by protein-protein interactions...