tenascin

Summary

Summary: Hexameric extracellular matrix glycoprotein transiently expressed in many developing organs and often re-expressed in tumors. It is present in the central and peripheral nervous systems as well as in smooth muscle and tendons. (From Kreis & Vale, Guidebook to the Extracellular Matrix and Adhesion Proteins, 1993, p93)

Top Publications

  1. pmc Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
    Thordur Oskarsson
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 17:867-74. 2011
  2. ncbi Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    Kim Midwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Nat Med 15:774-80. 2009
  3. pmc A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment
    Dion A Daniels
    Gene Expression and Protein Biochemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, England
    Proc Natl Acad Sci U S A 100:15416-21. 2003
  4. ncbi Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells
    Tomoki Ishigaki
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Tsu, Mie, Japan
    J Cell Physiol 226:2617-24. 2011
  5. pmc VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
    Joyce T O'Connell
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:16002-7. 2011
  6. pmc Tenascin-C deficiency attenuates TGF-ß-mediated fibrosis following murine lung injury
    William A Carey
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Am J Physiol Lung Cell Mol Physiol 299:L785-93. 2010
  7. ncbi The extracellular matrix glycoprotein tenascin-C promotes locomotor recovery after spinal cord injury in adult zebrafish
    Y M Yu
    W M Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, 604 Allison Road, NJ 08854, USA
    Neuroscience 183:238-50. 2011
  8. ncbi Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid
    A Laitinen
    Department of Anatomy, University of Helsinki, Finland
    Am J Respir Crit Care Med 156:951-8. 1997
  9. pmc Drosophila Ten-m and filamin affect motor neuron growth cone guidance
    Lihua Zheng
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e22956. 2011
  10. ncbi Expression of tenascin-C and its isoforms in the breast
    David S Guttery
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    Cancer Metastasis Rev 29:595-606. 2010

Detail Information

Publications315 found, 100 shown here

  1. pmc Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
    Thordur Oskarsson
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 17:867-74. 2011
    ..that breast cancer cells that infiltrate the lungs support their own metastasis-initiating ability by expressing tenascin C (TNC)...
  2. ncbi Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    Kim Midwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Nat Med 15:774-80. 2009
    ..b>Tenascin-C (encoded by Tnc) is an extracellular matrix glycoprotein specifically expressed at areas of inflammation and ..
  3. pmc A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment
    Dion A Daniels
    Gene Expression and Protein Biochemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, England
    Proc Natl Acad Sci U S A 100:15416-21. 2003
    ..Here we characterize the interaction of the DNA aptamer, GBI-10, with tenascin-C, an extracellular protein found in the tumor matrix...
  4. ncbi Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells
    Tomoki Ishigaki
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Tsu, Mie, Japan
    J Cell Physiol 226:2617-24. 2011
    ..b>Tenascin-C (TNC) is upregulated in the developing neointima of lesions...
  5. pmc VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
    Joyce T O'Connell
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:16002-7. 2011
    ..with a concomitant decrease in the expression of several ECM molecules and growth factors, particularly Tenascin-C and VEGF-A...
  6. pmc Tenascin-C deficiency attenuates TGF-ß-mediated fibrosis following murine lung injury
    William A Carey
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Am J Physiol Lung Cell Mol Physiol 299:L785-93. 2010
    b>Tenascin-C (TNC) is an extracellular matrix glycoprotein of unknown function that is highly expressed in adult lung parenchyma following acute lung injury (ALI)...
  7. ncbi The extracellular matrix glycoprotein tenascin-C promotes locomotor recovery after spinal cord injury in adult zebrafish
    Y M Yu
    W M Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, 604 Allison Road, NJ 08854, USA
    Neuroscience 183:238-50. 2011
    ..In the current study, the extracellular matrix glycoprotein tenascin-C was studied in the zebrafish spinal cord injury model to assess the often disparate functions of this ..
  8. ncbi Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid
    A Laitinen
    Department of Anatomy, University of Helsinki, Finland
    Am J Respir Crit Care Med 156:951-8. 1997
    b>Tenascin and fibronectin are extracellular matrix glycoproteins expressed during morphogenesis and tissue repair...
  9. pmc Drosophila Ten-m and filamin affect motor neuron growth cone guidance
    Lihua Zheng
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e22956. 2011
    The Drosophila Ten-m (also called Tenascin-major, or odd Oz (odz)) gene has been associated with a pair-rule phenotype...
  10. ncbi Expression of tenascin-C and its isoforms in the breast
    David S Guttery
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK
    Cancer Metastasis Rev 29:595-606. 2010
    b>Tenascin-C (TNC) is an extracellular matrix glycoprotein which is frequently up-regulated in a variety of pathological conditions including chronic inflammation and cancer...
  11. ncbi Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction
    K Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Mie, Japan
    Lab Invest 81:1015-24. 2001
    b>Tenascin-C (TNC), an extracellular matrix glycoprotein, plays important roles in tissue remodeling. TNC is not normally expressed in adults but reappears under pathologic conditions...
  12. pmc Advances in tenascin-C biology
    Kim S Midwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, NDORMS, Oxford University, 65 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Cell Mol Life Sci 68:3175-99. 2011
    b>Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury...
  13. pmc Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population
    M Fukunaga-Kalabis
    Molecular and Cellular Oncogenesis Program, Division of Molecular and Cellular Biology, The Wistar Institute, Philadelphia, PA 19104, USA
    Oncogene 29:6115-24. 2010
    b>Tenascin-C (TNC) is highly expressed in melanoma; however, little is known about its functions. Recent studies indicate that TNC has a role within the stem cell niche...
  14. ncbi The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling
    F S Jones
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Dev Dyn 218:235-59. 2000
    ..In contrast to many other ECM proteins, the tenascin (TN) family of glycoproteins (TN-C, TN-R, TN-W, TN-X, and TN-Y) display highly restricted and dynamic patterns of ..
  15. pmc Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth
    P L Jones
    Division of Cardiovascular Research, Research Institute, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Cell Biol 139:279-93. 1997
    b>Tenascin-C (TN-C) is induced in pulmonary vascular disease, where it colocalizes with proliferating smooth muscle cells (SMCs) and epidermal growth factor (EGF)...
  16. ncbi Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins
    P Sriramarao
    La Jolla Institute for Experimental Medicine, CA 92037
    J Cell Sci 105:1001-12. 1993
    Human umbilical vein endothelial cells were found to attach and partially spread on human tenascin. The attachment of endothelial cells to tenascin results in elongated cells with interconnecting processes and is distinct from the ..
  17. ncbi Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C
    K Adamsky
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Oncogene 20:609-18. 2001
    ..One of these, a 240 kDa protein that was purified from U118MG glioblastoma cell, was identified as tenascin C based on the amino acid sequence of several tryptic peptides...
  18. ncbi Severe cognitive and motor coordination deficits in tenascin-R-deficient mice
    M Montag-Sallaz
    Neurogenetics Research Group, Leibniz Institute for Neurobiology, Brenneckestr, Magdeburg, Germany
    Genes Brain Behav 2:20-31. 2003
    The extracellular matrix molecule tenascin-R (TN-R), predominantly expressed in the central nervous system, has been implied in a variety of functions, e.g...
  19. pmc Oxidative damage and TGF-β differentially induce lung epithelial cell sonic hedgehog and tenascin-C expression: implications for the regulation of lung remodelling in idiopathic interstitial lung disease
    Paul M Fitch
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    Int J Exp Pathol 92:8-17. 2011
    ..with lung damage and repair) was functional and whether the damage associated extracellular matrix protein tenascin-C was present in activated Type-II AECs in all three iILDs...
  20. ncbi Interactions of human tenascin-X domains with dermal extracellular matrix molecules
    David Egging
    Department of Dermatology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Arch Dermatol Res 298:389-96. 2007
    b>Tenascin-X (TNX) is a large 450 kDa extracellular matrix protein expressed in a variety of tissues including skin, joints and blood vessels...
  21. ncbi Tenascins: regulation and putative functions during pathological stress
    Ruth Chiquet-Ehrismann
    Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Pathol 200:488-99. 2003
    ..In this review, we discuss the structure and function of the extracellular matrix protein family of tenascins with emphasis on their involvement in human pathologies. The article is divided into the following sections:..
  22. pmc Endogenous control of immunity against infection: tenascin-C regulates TLR4-mediated inflammation via microRNA-155
    Anna M Piccinini
    Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, 65 Aspenlea Road, London W6 8LH, UK
    Cell Rep 2:914-26. 2012
    ..b>Tenascin-C is an extracellular matrix glycoprotein that is specifically induced upon injury and infection...
  23. pmc Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration
    Ayako Nakamura-Ishizu
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    Blood 119:5429-37. 2012
    ..Of the many ECM proteins, the expression of tenascin-C (TN-C) was found to be dramatically up-regulated during hematopoietic recovery after myeloablation...
  24. ncbi The tenascin-C knockout revisited
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    J Cell Sci 112:3847-53. 1999
    In the past seven years, two groups have independently produced tenascin-C-knockout mice. These mice are born alive and, originally, were described as showing no abnormalities...
  25. ncbi Tenascin-C is expressed in abdominal aortic aneurysm tissue with an active degradation process
    Taizo Kimura
    Department of Molecular Cardiovascular Biology, Yamaguchi University School of Medicine, Kurume, Japan
    Pathol Int 61:559-64. 2011
    ..Currently no biomarkers have been established to indicate the disease status of AAA. Tenascin-C (TN-C) is a matricellular protein that is synthesized under pathological conditions...
  26. pmc Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R
    J Srinivasan
    Departments of Pharmacology and Neurological Surgery, University of Washington, Seattle, WA 98195 7280, USA
    Proc Natl Acad Sci U S A 95:15753-7. 1998
    ..the cell adhesion molecule contactin (also called F3 or F11), which binds to the extracellular matrix molecules tenascin-C and tenascin-R...
  27. ncbi Alteration of inflammatory cytokine production in the injured central nervous system of tenascin-deficient mice
    Hiroko Ikeshima-Kataoka
    Department of Molecular Immunology, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
    In Vivo 22:409-13. 2008
    Although tenascin-C (TN) is highly up-regulated during the proliferation of reactive astrocytes, little is known about the function of TN at injury sites in the central nervous system (CNS)...
  28. pmc Regeneration of the perineurium after microsurgical resection examined with immunolabeling for tenascin-C and alpha smooth muscle actin
    Michiro Yamamoto
    Department of Hand Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Anat 218:413-25. 2011
    ..Our hypothesis is that the regenerative process of the perineurium can be demonstrated by immunolabeling for tenascin-C and alpha smooth muscle actin after microsurgical resection of the perineurium in vivo...
  29. ncbi The structure and function of tenascins in the nervous system
    A Joester
    Department of Neurobiology, Im Neuenheimer Feld 364, D 69120, Heidelberg, Germany
    Matrix Biol 20:13-22. 2001
    ..Three of these, tenascin-C (TN-C) tenascin-R (TN-R) and tenascin-Y (TN-Y) are expressed in specific patterns during nervous system ..
  30. ncbi Regulation of fibroblast migration by tenascin-C
    A Trebaul
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Biochem Soc Trans 35:695-7. 2007
    ..Excessive deposition of scar tissue is the major hallmark of fibrotic disease. Tenascin-C is an extracellular matrix glycoprotein that is transiently expressed upon tissue injury, where it is ..
  31. ncbi Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation
    W Huang
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Cancer Res 61:8586-94. 2001
    b>Tenascin-C is an adhesion-modulatory extracellular matrix molecule that is highly expressed in tumors...
  32. ncbi The extracellular matrix molecule tenascin C modulates expression levels and territories of key patterning genes during spinal cord astrocyte specification
    Michael Karus
    Department for Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, Universitatsstrasse 150, Bochum, Germany
    Development 138:5321-31. 2011
    ..Here, we demonstrate for the first time that the extracellular matrix glycoprotein tenascin C regulates the expression of key patterning genes during late embryonic spinal cord development, leading to a ..
  33. ncbi Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension
    Kaori Ihida-Stansbury
    University of Pennsylvania, Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, Philadelphia, PA 19104 6383, USA
    Am J Physiol Lung Cell Mol Physiol 291:L694-702. 2006
    ..Here we show that pulmonary vascular lesions from patients harboring BMPR2 mutations express high levels of tenascin-C (TN-C), an extracellular matrix glycoprotein that promotes pulmonary artery (PA) smooth muscle cell (SMC) ..
  34. pmc The adhesion modulating properties of tenascin-W
    Florence Brellier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Int J Biol Sci 8:187-94. 2012
    Tenascins are extracellular matrix glycoproteins associated with cell motility, proliferation and differentiation. Tenascin-C inhibits cell spreading by binding to fibronectin; tenascin-R and tenascin-X also have anti-adhesive properties ..
  35. ncbi Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrix glycoprotein tenascin-R
    A K Saghatelyan
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, Hamburg, D 20246, Germany
    Mol Cell Neurosci 17:226-40. 2001
    The role of the extracellular matrix molecule tenascin-R (TN-R) in regulation of synaptic transmission and plasticity in the CA1 region of the hippocampus was studied using mice deficient in expression of this molecule...
  36. ncbi The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with achilles tendon injuries
    Gaonyadiwe G Mokone
    UCT MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, PO Box 115, Newlands 7725, South Africa
    Am J Sports Med 33:1016-21. 2005
    ..The tenascin-C gene, which has been mapped to chromosome 9q32-q34, encodes for a structural component of tendons.
  37. ncbi Tenascin-C is a useful marker for disease activity in myocarditis
    Kyoko Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Japan
    J Pathol 197:388-94. 2002
    b>Tenascin-C (TNC) is an extracellular matrix protein which appears at active sites of tissue remodelling during embryogenesis or cancer invasion...
  38. ncbi Opposite effect of fluticasone and salmeterol on fibronectin and tenascin-C expression in primary human lung fibroblasts
    M Degen
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Clin Exp Allergy 39:688-99. 2009
    ..Current therapies for asthma and COPD consist of inhaled corticosteroids and long-acting beta(2)-agonists (LABA). However, their effect on airway remodelling is not well understood so far...
  39. ncbi Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma
    Christoph Schliemann
    Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Leuk Res 33:1718-22. 2009
    ..are clinical-stage human monoclonal antibodies, which selectively recognize splice isoforms of fibronectin and tenascin-C in the modified extracellular matrix of neoplastic lesions...
  40. ncbi Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteins
    N Dandachi
    Institute of Pathological Anatomy, Landeskliniken Salzburg, Salzburg, Austria
    J Pathol 193:181-9. 2001
    ..In human breast carcinomas, up-regulation of tenascin-C (TN-C) and vimentin (Vim) is frequently observed in cancer cells and correlates with increased malignancy...
  41. ncbi Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma
    E M Karjalainen
    Clinical Research Unit of Pulmonary Medicine, Department of Medicine, Helsinki University Central Hospital, Finland
    Respir Med 97:1045-51. 2003
    ..study was set to investigate the bronchial inflammatory cell infiltrate and subepithelial basement membrane (BM) tenascin deposition in subjects with newly diagnosed asthma and bronchial hyperresponsiveness (BHR)...
  42. pmc Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture
    Isao Kii
    Department of Biological Information, Tokyo Institute of Technology, 4259 Midori ku, Nagatsuta, Yokohama 226 8501
    J Biol Chem 285:2028-39. 2010
    ..Here we show that periostin, a matricellular protein, promotes incorporation of tenascin-C into the ECM and organizes a meshwork architecture of the ECM...
  43. ncbi Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse
    Hiroki Nakahara
    Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu City, Japan
    Eur J Immunol 36:3334-45. 2006
    b>Tenascin C (TN-C) is an extracellular matrix glycoprotein whose expression is increased in several inflammatory diseases of the lung, including bronchial asthma...
  44. pmc Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6
    Michael R Zalutsky
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Nucl Med 49:30-8. 2008
    ..The main goal of this study was to investigate the feasibility and safety of this approach in patients with recurrent malignant brain tumors...
  45. ncbi Corneal femtosecond laser keratotomy results in isolated stromal injury and favorable wound-healing response
    Christian Meltendorf
    Department of Ophthalmology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Invest Ophthalmol Vis Sci 48:2068-75. 2007
    ..To examine the corneal repair response after intrastromal femtosecond (fs) laser keratotomy...
  46. ncbi Tenascin-C in development and disease: gene regulation and cell function
    P L Jones
    Pediatric Cardiology Research, Abramson Research Center, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA, 19104, USA
    Matrix Biol 19:581-96. 2000
    b>Tenascin-C (TN-C) is a modular and multifunctional extracellular matrix (ECM) glycoprotein that is exquisitely regulated during embryonic development and in adult tissue remodeling...
  47. ncbi beta-Catenin regulates the expression of tenascin-C in human colorectal tumors
    Katharina Beiter
    Pathologisch Anatomisches Institut, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Oncogene 24:8200-4. 2005
    b>Tenascin-C (TN-C) is a component of the extracellular matrix (ECM). It is expressed during development and re-expressed in many types of cancers, where it is involved in the modulation of adhesion and proliferation...
  48. pmc Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis
    A Calvo
    Laboratory of Cancer Biology and Genetics, NCI, NIH, Bethesda, MD 20892, USA
    Oncogene 27:5373-84. 2008
    ..this set of genes with a human breast cancer lung metastasis gene signature identified five common targets: tenascin-C(TNC), matrix metalloprotease-2, collagen-6-A1, mannosidase-alpha-1A and HLA-DPA1...
  49. ncbi IGF signaling between blastema and wound epidermis is required for fin regeneration
    Fabian Chablais
    Unit of Anatomy, Department of Medicine, University of Fribourg, Rte A Gockel 1, CH 1700 Fribourg, Switzerland
    Development 137:871-9. 2010
    ..Thus, IGF signaling upregulated upon fin amputation represents a signal from the blastema to the wound epithelium, a crucial step in appendage regeneration...
  50. ncbi Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development
    Joy Lincoln
    Division of Molecular Cardiovascular Biology, MLC 7020, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 294:292-302. 2006
    ..This review will focus on the regulatory hierarchies that control normal and abnormal heart valve development in parallel with other connective tissue cell types...
  51. pmc Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues
    T Oohashi
    Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 145:563-77. 1999
    ..Far Western assays and electronmicroscopy demonstrated that Ten-m1 can bind to itself...
  52. ncbi Mice develop normally without tenascin
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Genes Dev 6:1821-31. 1992
    b>Tenascin, an extracellular matrix protein, is expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena...
  53. ncbi Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin
    Gesa Rascher
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, Germany
    Acta Neuropathol 104:85-91. 2002
    ..despite a high variability of vascular phenotypes, the loss of agrin strongly correlated with the expression of tenascin, an extracellular matrix molecule which has been described previously to be absent in mature non-pathological ..
  54. pmc Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
    Ethan David Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:2538-49. 2009
    ..the effect on Pdgfr expression was, in part, mediated by direct transcriptional regulation of the ECM protein tenascin C (Tnc), which was necessary and sufficient for Pdgfralpha/beta expression in lung explants...
  55. ncbi Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator
    Florence Brellier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    FEBS Lett 585:913-20. 2011
    We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression...
  56. pmc Involvement of large tenascin-C splice variants in breast cancer progression
    Takatsugu Tsunoda
    Department of Pathology, Mie University School of Medicine, Mie, Japan
    Am J Pathol 162:1857-67. 2003
    Alternative splicing of fibronectin-like type III (FNIII) repeats of tenascin-C (Tn-C) generates a number of splice variants...
  57. ncbi A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency
    J Schalkwijk
    Department of Dermatology, University Medical Center Nijmegen, The Netherlands
    N Engl J Med 345:1167-75. 2001
    ..We investigated whether the deficiency of the tenascins, extracellular-matrix proteins that are highly expressed in connective tissues, was associated with the Ehlers-Danlos syndrome...
  58. ncbi Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development
    A Scherberich
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Cell Sci 117:571-81. 2004
    We cloned and characterized a novel member of the tenascin family of extracellular matrix proteins--the murine orthologue of zebrafish tenascin-W. Full-length recombinant tenascin-W was expressed and purified from mammalian cell cultures...
  59. ncbi Alternative splicing in the aggrecan G3 domain influences binding interactions with tenascin-C and other extracellular matrix proteins
    Joanna M Day
    The Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 279:12511-8. 2004
    ..Here we identify tenascin-C as a ligand for the lectins of all these proteoglycans and map the binding site on the tenascin molecule to ..
  60. ncbi Prognostic value of serum tenascin-C levels on long-term outcome after acute myocardial infarction
    Akira Sato
    Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
    J Card Fail 18:480-6. 2012
    b>Tenascin-C (TN-C), an extracellular matrix glycoprotein, is not normally expressed in the adult heart but transiently reappears under various pathologic conditions to play important roles in tissue remodeling...
  61. ncbi Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma
    Banu Sis
    Department of Pathology, School of Medicine, Dokuz Eylul University, Inciralti, Izmir 35340, Turkey
    Pathol Res Pract 200:379-87. 2004
    ..play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment...
  62. ncbi Tenascin-C and the development of articular cartilage
    M Pacifici
    Department of Anatomy and Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, USA
    Matrix Biol 14:689-98. 1995
    ..this minireview, we summarize recent studies from our laboratory suggesting that the extracellular matrix protein tenascin-C is involved in the genesis and function of articular chondrocytes...
  63. ncbi Meet the tenascins: multifunctional and mysterious
    Henry C Hsia
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 280:26641-4. 2005
  64. ncbi Tenascin-C patterns and splice variants in actinic keratosis and cutaneous squamous cell carcinoma
    C Dang
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 155:763-70. 2006
    b>Tenascin-C (Tn-C) is an extracellular matrix protein with multiple functions that is present at low levels in normal tissues, but which is highly present in various tumours...
  65. pmc Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury
    Masashi Tamaoki
    Department of Pathology and Biology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Am J Pathol 167:71-80. 2005
    b>Tenascin-C (TN-C) is an extracellular matrix molecule that is expressed during wound healing in various tissues. Although not detectable in the normal adult heart, it is expressed under pathological conditions...
  66. ncbi Tenascin-C promotes neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule F3/contactin
    Franck Rigato
    Laboratoire de Neurobiologie du Développement et de la Régénération, Centre National de la Recherche Scientifique, Formation der Recherche en Evolution 2373, F 67084 Strasbourg, France
    J Neurosci 22:6596-609. 2002
    b>Tenascin-C is a multimodular glycoprotein that possesses neurite outgrowth-stimulating properties, and one functional site has been localized to the alternatively spliced fibronectin type III domain D...
  67. ncbi SMOC1 is a tenascin-C interacting protein over-expressed in brain tumors
    Florence Brellier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Matrix Biol 30:225-33. 2011
    b>Tenascin-C is an extracellular matrix protein over-expressed in a large variety of cancers. In the present study, we aimed at identifying new interactors of tenascin-C by purifying secreted proteins on a tenascin-C affinity column...
  68. ncbi Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth
    Ellen Van Obberghen-Schilling
    CNRS UMR6543, IBDC, Nice, France
    Int J Dev Biol 55:511-25. 2011
    ..Here we will review what is known about the role of the ECM molecules fibronectin and tenascin-C in the vasculature and highlight a potential collaborative interplay between these molecules in developmental ..
  69. pmc Tenascin-C enhances pancreatic cancer cell growth and motility and affects cell adhesion through activation of the integrin pathway
    Igor Paron
    Institute of Pathology, Helmholtz Zentrum Munchen, Germany
    PLoS ONE 6:e21684. 2011
    Pancreatic cancer (PDAC) is characterized by an abundant fibrous tissue rich in Tenascin-C (TNC), a large ECM glycoprotein mainly synthesized by pancreatic stellate cells (PSCs)...
  70. ncbi The role of tenascin C in cardiovascular disease
    Jonathan Golledge
    Vascular Biology Unit, Department of Surgery, School of Medicine and Dentistry, James Cook University, Townsville QLD 4811, Australia
    Cardiovasc Res 92:19-28. 2011
    The extracellular matrix protein tenascin C (TnC) is expressed in a variety of embryonic tissues, but its expression in adult arteries is co-incident with sites of vascular disease...
  71. ncbi Differential regulation of fibulin, tenascin-C, and nidogen expression during wound healing of normal and glucocorticoid-treated mice
    R Fassler
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    Exp Cell Res 222:111-6. 1996
    Expression and distribution of fibulins, nidogen, and tenascin-C were analyzed in healing skin wounds of normal and dexamethasone-treated mice...
  72. ncbi The transcriptional regulator megakaryoblastic leukemia-1 mediates serum response factor-independent activation of tenascin-C transcription by mechanical stress
    Maria B Asparuhova
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    FASEB J 25:3477-88. 2011
    The extracellular matrix protein tenascin-C (TNC) is up-regulated in processes influenced by mechanical stress, such as inflammation, tissue remodeling, wound healing, and tumorigenesis...
  73. ncbi Expression and immune function of tenascin-C
    Irina A Udalova
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, United Kingdom
    Crit Rev Immunol 31:115-45. 2011
    ..b>Tenascin-C is a large, extracellular matrix glycoprotein that has a very tightly controlled pattern of expression...
  74. ncbi Different patterns of fibronectin and tenascin-C splice variants expression in primary and metastatic melanoma lesions
    Katharina Frey
    Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
    Exp Dermatol 20:685-8. 2011
    ..specific to the alternatively spliced extra domain A and extra domain B domains of fibronectin and A1 domain of tenascin-C, respectively. Blood vessels were costained using von Willebrand factor-specific antibodies...
  75. ncbi A model of tenascin-X integration within the collagenous network
    Claire Lethias
    Institut de Biologie et Chimie des Proteines, IFR 128 Biosciences Lyon Gerland, CNRS UMR 5086, Universite de Lyon, 7 passage du Vercors, 69367 Lyon Cedex 07, France
    FEBS Lett 580:6281-5. 2006
    b>Tenascin-X is an extracellular matrix protein whose absence leads to an Ehlers-Danlos syndrome in humans, characterized mainly by disorganisation of collagen and elastic fibril networks...
  76. pmc Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease
    Mollie A Minear
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Genet 129:641-54. 2011
    b>Tenascin-C (TNC) is an extracellular matrix protein implicated in biological processes important for atherosclerotic plaque development and progression, including smooth muscle cell migration and proliferation...
  77. ncbi Hoxb-5 down regulation alters Tenascin-C, FGF10 and Hoxb gene expression patterns in pseudoglandular period fetal mouse lung
    MaryAnn V Volpe
    Department of Pediatrics, Division of Newborn Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Front Biosci 12:860-73. 2007
    ..Hoxb-5 regulation in fetal lung affects ECM expression of tenascin-C and alters FGF10 spatial and cellular expression. To test this hypothesis, gestational day 13.5 (Gd13...
  78. ncbi Fibronectin domains of extracellular matrix molecule tenascin-C modulate hippocampal learning and synaptic plasticity
    Tatyana Strekalova
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Mol Cell Neurosci 21:173-87. 2002
    The extracellular matrix molecule tenascin-C (TN-C) has been shown to be involved in hippocampal synaptic plasticity in vitro...
  79. pmc Tenascin and aggrecan expression by articular chondrocytes is influenced by interleukin 1beta: a possible explanation for the changes in matrix synthesis during osteoarthritis
    D Pfander
    Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 63:240-4. 2004
    To analyse the distribution patterns of tenascin and proteoglycans in normal and osteoarthritic cartilage, and to determine the effect of interleukin 1beta (IL1beta) on aggrecan and tenascin expression by human articular chondrocytes in ..
  80. ncbi Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression
    Jyun Yuan Huang
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
    J Immunol 185:1450-9. 2010
    ..Glioma cells, but not MCF-7 and HepG2 cells, expressed tenascin-C...
  81. pmc Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C
    Sai Ichi Tanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 16:1194-205. 2010
    To investigate the role of tenascin-C in epithelial-mesenchymal transition (EMT) of the lens epithelium during wound healing in mice...
  82. pmc Localized expression of tenascin in systemic sclerosis-associated pulmonary fibrosis and its regulation by insulin-like growth factor binding protein 3
    Monique Brissett
    University of Pittsburgh, Department of Medicine, Pittsburgh, Pennsylvania 15231, USA
    Arthritis Rheum 64:272-80. 2012
    ..growth factor binding protein 3 (IGFBP-3) in mediating the effects of transforming growth factor β (TGFβ) on tenascin-C (TN-C) production and to assess the levels of TN-C in vivo in patients with systemic sclerosis (SSc)-associated ..
  83. ncbi Mechanical loading regulates the expression of tenascin-C in the myotendinous junction and tendon but does not induce de novo synthesis in the skeletal muscle
    Tero A H Järvinen
    Institute of Medical Technology and Medical School, University of Tampere, Tampere, Finland
    J Cell Sci 116:857-66. 2003
    b>Tenascin-C is a hexabrachion-shaped matricellular protein with a very restricted expression in normal musculoskeletal tissues, but it is expressed abundantly during regenerative processes of these tissues and embryogenesis...
  84. ncbi Zebrafish tenascin-W, a new member of the tenascin family
    P Weber
    Department of Neurobiology, Swiss Federal Institute of Technology, Honggerberg, HPM, Zurich
    J Neurobiol 35:1-16. 1998
    A cDNA clone encoding tenascin-W, a novel member of the tenascin family, was isolated from a 20- to 28-h postfertilization (hpf) zebrafish cDNA library on the basis of the conserved epidermal growth factor-like domains represented in all ..
  85. ncbi Expression of extracellular matrix components versican, chondroitin sulfate, tenascin, and hyaluronan, and their association with disease outcome in node-negative breast cancer
    Supaporn Suwiwat
    Dame Roma Mitchell Cancer Research Laboratory, Hanson Institute, Adelaide University, Adelaide, South Australia
    Clin Cancer Res 10:2491-8. 2004
    ..The purpose is to determine whether the levels of expression of extracellular matrix components in peritumoral stroma are predictive of disease outcome for women with node-negative breast cancer...
  86. ncbi Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta
    Jurgen Brinckmann
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Lab Invest 90:739-52. 2010
    ..Double labelling of fibrillin-2 and tenascin-C, which is also expressed in wound healing and sclerosis, showed co-localization of both proteins...
  87. ncbi Endogenous activation of adaptive immunity: tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease
    Michaela Ruhmann
    Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK
    Arthritis Rheum 64:2179-90. 2012
    ..b>Tenascin-C is an arthritogenic extracellular matrix glycoprotein that is not expressed in healthy synovium but is elevated ..
  88. ncbi Immunohistochemical expression of fibronectin and tenascin in human tooth pulp capped with mineral trioxide aggregate and a novel endodontic cement
    Mohammad Hassan Zarrabi
    Department of Endodontics, School of Dentistry and Dental Research Center, University of Medical Sciences, Mashhad, and Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    J Endod 37:1613-8. 2011
    The purpose of the present study was the immunohistochemical study of fibronectin (FN) and tenascin (TN) in human tooth pulp capped with mineral trioxide aggregate (MTA) and novel endodontic cement (NEC) (calcium enriched mixture cement) ..
  89. pmc Enhanced tenascin expression in cervical and vulvar koilocytotic lesions
    O Tiitta
    Department of Anatomy, University of Helsinki, Finland
    Am J Pathol 141:907-13. 1992
    b>Tenascin is an extracellular matrix glycoprotein that is widely expressed during embryogenesis...
  90. pmc Tenascin-C suppresses Rho activation
    M B Wenk
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    J Cell Biol 150:913-20. 2000
    ..b>Tenascin-C, a developmentally regulated matrix protein, modulates cellular responses to other matrix proteins, such as ..
  91. ncbi Tenascin-W: an extracellular matrix protein associated with osteogenesis and cancer
    Enrico Martina
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Int J Biochem Cell Biol 42:1412-5. 2010
    b>Tenascin-W was the last member of a family of four large extracellular matrix glycoproteins to be discovered...
  92. ncbi Well-defined clinical presentation of Ehlers-Danlos syndrome in patients with tenascin-X deficiency: a report of four cases
    Anke G M Hendriks
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Dysmorphol 21:15-8. 2012
    ..Shortly after the publication of these criteria in 1998, a further distinct type of EDS, the tenascin-X (TNX)-deficient type EDS, was reported...
  93. pmc Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions
    E Aufderheide
    Friederich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    J Cell Biol 107:2341-9. 1988
    b>Tenascin, an extracellular matrix protein, is expressed in the mesenchyme around growing epithelia in the embryo. We therefore investigated whether epithelial cells can stimulate expression of tenascin in embryonic mesenchyme...
  94. pmc The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C
    B Varnum-Finney
    Department of Physiology, University of California, San Francisco 94143 0724, USA
    Neuron 14:1213-22. 1995
    This paper identifies a neuronal receptor for tenascin-C (tenascin/cytotactin), an extracellular matrix protein that has previously been detected in developing sensory and motor neuron pathways and has been shown to regulate cell ..
  95. pmc Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro
    Enrico Martina
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    FASEB J 24:778-87. 2010
    ..Among the extracellular matrix proteins enriched in the stroma of carcinomas are the tenascin family members tenascin-C and tenascin-W...
  96. pmc Integrins mediate adhesion of medulloblastoma cells to tenascin and activate pathways associated with survival and proliferation
    Paul Fiorilli
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
    Lab Invest 88:1143-56. 2008
    ..The H4 ECM was enriched in tenascin, a binding partner for the alpha9beta1 integrin heterodimer. Purified tenascin-C supported D283 cell adhesion...
  97. ncbi Matrix metalloproteinase-19 deficiency promotes tenascin-C accumulation and allergen-induced airway inflammation
    Maud M Gueders
    Department of Respiratory Diseases, University of Liege and Centre Hospitalier Universitaire, Belgium
    Am J Respir Cell Mol Biol 43:286-95. 2010
    ..MMP-19 is newly described, and it preferentially cleaves matrix proteins such as collagens and tenascin-C. The role of MMP-19 in asthma has not been described to date...
  98. pmc Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells
    Keiki Nagaharu
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Mie, Japan
    Am J Pathol 178:754-63. 2011
    b>Tenascin C (TNC) is an extracellular matrix glycoprotein up-regulated in solid tumors. Higher TNC expression is shown in invading fronts of breast cancer, which correlates with poorer patient outcome...
  99. ncbi Tenascin expression and distribution in pleural inflammatory and fibrotic diseases
    R Kaarteenaho-Wiik
    Department of Pathology, University of Oulu, Oulu, Finland
    J Histochem Cytochem 48:1257-68. 2000
    We hypothesized that tenascin expression is increased in pleural inflammatory and fibrotic diseases and that its expression can be used as a marker of active pleural involvement...
  100. ncbi Relevance of tenascin-C and matrix metalloproteinases in vascular abnormalities in murine hypoplastic lungs
    Mala R Chinoy
    Lung Development Research Program, Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biol Neonate 90:185-96. 2006
    b>Tenascin-C (TN-C), an extracellular matrix glycoprotein, is crucial to cell-migration, proliferation, apoptosis and remodeling of tissues, with a potential role in pathobiology of pulmonary hypertension...
  101. ncbi Impairment of L-type Ca2+ channel-dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin-C
    Matthias R Evers
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    J Neurosci 22:7177-94. 2002
    The extracellular matrix glycoprotein tenascin-C (TN-C) has been suggested to play important functional roles during neural development, axonal regeneration, and synaptic plasticity...

Research Grants62

  1. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
    ..In the second aim we propose to delineate the role of the extracellular matrix protein, tenascin-C, in Tat and cocaine mediated activation of the PDGFR axis...
  2. Thrombospondins and other matricellular proteins in tissue organization and homeo
    Joanne E Murphy Ullrich; Fiscal Year: 2010
    ..the ECM, these proteins have been termed matricellular proteins and include members of the thrombospondin, CCN, tenascin, SIBLING, and SPARC families...
  3. Role of the Giant Protein Titin in Skeletal Muscle Structure and Function
    Henk L Granzier; Fiscal Year: 2013
    ..Titin's role in disease will also be studied in tenascin-X (TNX) deficient patients (one of the types of Ehlers-Danlos syndrome) and TNX KO mice;our preliminary data ..
  4. FASEB SRC on Matricellular Proteins in Development, Health, and Disease
    Joanne E Murphy-Ullrich; Fiscal Year: 2013
    ..the ECM, these proteins have been termed matricellular proteins and include members of the thrombospondin, CCN, tenascin, osteopontin, periostin, fibulin, and SPARC families...
  5. Genomic targets of oncoproteins and tumor suppressors
    Kevin Struhl; Fiscal Year: 2013
    ..Let-7 in many respects, we will perform similar mechanistic experiments to determine how miR-335 (and its targets tenascin C and Sox4 transcription factor) contributes to the process linking inflammation to cellular transformation...
  6. Targeted Liposomal Delivery of CD147 siRNA to Murine Head and Neck Cancer Models
    Nadarajah Vigneswaran; Fiscal Year: 2010
    ..silencing of CD147 leads to concomitant decreases in the mRNA levels of MMP-9, MMP-13, Adamts 1, and tenascin-C...
  7. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..Furthermore, we demonstrate that VEGF, SDF-1 and Tenascin-C, might mediate the formation of metastatic nodules...
  8. IDENTIFICATION OF VUR GENES BY COMBINED LINKAGE ANALYSIS AND EXOME SEQUENCING
    RASHEED ADEBAYO GBADEGESIN; Fiscal Year: 2013
    ..We performed exome sequencing on affected individuals in the family and identified mutations in tenascin XB (TNXB) as a cause of familial VUR...
  9. STRUCTURAL AND BIOCHEMICAL STUDIES OF PROTEIN TYROSINE PHOSPHATASE FUNCTION
    Samuel Bouyain; Fiscal Year: 2013
    ..is expressed predominantly on glial cells and has been associated with multiple binding partners such as tenascin-C in the extracellular matrix and contactin1 on neurons...
  10. Interleukin-8 Induced Biology in Benign Prostatic Hyperplasia
    David Rowley; Fiscal Year: 2009
    ..and that this correlated significantly with a myofibroblast reactive stroma phenotype with altered expression of tenascin. IL-8 is a potent chemokine that induces chemotaxis of many cell types stimulates reactive stroma / wound repair ..
  11. Biology of Melanoma Metastasis
    MEENHARD FOLKENS HERLYN; Fiscal Year: 2013
    ..For cell-matrix interactions, we will focus on the matricellular protein tenascin C, which is highly produced by melanoma cells and is expressed by stromal fibroblasts...
  12. Interleukin-8 Induced Biology in Benign Prostatic Hyperplasia
    David R Rowley; Fiscal Year: 2013
    ..this correlated significantly with a myofibroblast reactive stroma phenotype with altered expression patterns of tenascin. IL-8 is a potent chemokine that induces chemotaxis of marrow-derived cells and stimulates reactive stroma / ..
  13. Biological Basis of Breast Density and Cancer Risk
    Thea D Tlsty; Fiscal Year: 2010
    ..In these processes, "activated stroma" results in increased levels of collagen and tenascin, stromal remodeling and altered cell cycle control for cellular components located within...
  14. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..bind specifically and with high affinity to neural cell adhesion molecules and the extracellular matrix protein tenascin. It is now planned to explore the roles of neurocan and phosphacan in neurobiological processes using both ..
  15. Role of wound provisional matrix in endothelial function
    Henry Hsia; Fiscal Year: 2009
    ..allowing incorporation of fibronectin (FN) and other ECM proteins will be used to determine the roles of FN and tenascin-C, important components of the wound matrix, in controlling endothelial cell reorganization into 3D tube ..
  16. GLIA AND GLYCOCONJUGATES IN THE NEOSTRIATUM
    Dennis Steindler; Fiscal Year: 1999
    ..circuit during development and in the adult, and antibody perturbation experiments versus studies on a tenascin-knockout mouse will provide complementary data on possible functions of particular ECM boundary molecules on ..
  17. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009
    ..and Col2a1;interzone cells, Gdf5;early articular chondrocytes, Pg4 (lubricin) and mature articular cells, tnc (tenascin c) and Col2a1...
  18. MACROMOLECULAR ARRAYS IN EXTRACELLULAR MATRIX OF COCHLEA
    Vladimir Tsuprun; Fiscal Year: 2003
    ..of regularly distributed fibronectin fibrils in the basilar membrane and their association with collagen, tenascin, and other molecules will be studied...
  19. Experimental Model For Pressure Ulcers In Human Skin: The Role of Aging and ECM
    Marjana Tomic Canic; Fiscal Year: 2009
    ..in skin specimens in the absence or presence of compressive load: 1) extra cellular matrix (ECM) properties (tenascin, fibronectin, elastin, procollagen, collagen, matrix metalloproteinases (MMP)) and its signaling (integrins, FAK ..
  20. Tenascin in Chondrosarcoma Metastasis
    Sean Scully; Fiscal Year: 2004
    ..expression is an independent prognostic indicator in human chondrosarcoma; (2) we have also demonstrated that tenascin-C expression, synthesis, and matrix incorporation are distinctly different in chondrosarcoma tissue compared to ..
  21. TENASCIN-X AND THE EHLERS-DANLOS PHENOTYPE
    James Bristow; Fiscal Year: 2002
    ..Recently, the PI's laboratory identified two unrelated patients with EDS due to deficiency of tenascin-X (TN-X), a large matrix glycoprotein...
  22. Molecular Analysis in Classical Ehlers-Danlos Syndrome
    Anna Mitchell; Fiscal Year: 2009
    ..in the COL5A1, COL5A2 (components of type V collagen), COL1A1, COL1A2 (components of type I collagen), and TNXB (tenascin X) genes resulting in the phenotype...
  23. GROWTH FACTOR INDUCED TENASCIN C IN DIABETIC RETINOPATHY
    Alexander Ljubimov; Fiscal Year: 2000
    ..The hypothesis to be tested is that vascular endothelial growth factor stimulates endothelial cell tenascin-C expression and its deposition in retinal neovascular basement membrane...
  24. NERVE SPROUTING AND ELECTRICAL REMODELING
    Peng Sheng Chen; Fiscal Year: 2003
    ..We will use in-situ hybridization and immunocytochemical staining to detect NGF mRNA and the tenascin proteins in a canine model of MI...
  25. Intrathecal Cancer Therapy using I131 NaI
    Franklin Wong; Fiscal Year: 2002
    ..Others using tumor-specific I-131 labeled anti-tenascin monoclonal antibodies have found partial therapeutic success but encountered hematotoxicity...
  26. PG-NG2 AND BIOLOGY OF 02A GLIAL PROGENITOR CELLS
    William Stallcup; Fiscal Year: 2000
    ..Extracellular matrix-associated ligands for NG2 include type VI collagen, thrombospondin, tenascin, and laminin, while membrane associated ligands include the PDGF alpha receptor...
  27. A model for wrist and elbow musculoskeletal disorders
    David Rempel; Fiscal Year: 2004
    ..The antigentic location and density of structural proteins (collagen I,II, ifi, decorin, tenascin, fibronectin), and various cytokines (IL- lb...
  28. PKCepsilon-Related Proteins in Lung Fibrosis
    Stanley Hoffman; Fiscal Year: 2006
    ..The extracellular matrix protein tenascin is overexpressed in scleroderma lung fibroblasts due to altered PKC-epsilon signaling...
  29. MOLECULAR CHANGES IN DIFFERENTIATING DENTAL MESENCHYME
    Irma Thesleff; Fiscal Year: 1992
    ..Specific emphasis is given to syndecan, a recently characterized cell surface molecule, and tenascin, a matrix glycoprotein, which are expressed in the dental mesenchyme during early tooth morphogenesis, but also ..
  30. MATRIX REMODELING IN ORAL SQUAMOUS CELL CARCINOMA
    Daniel Ramos; Fiscal Year: 2000
    ..Our group has shown that the ECM molecule tenascin-C (TN-C) and its integrin receptor, alphavbeta6, are neo-expressed in oral SCC...
  31. FUNCTION OF A NOVEL AIRWAY EPITHELIAL ADHESION RECEPTOR
    Dean Sheppard; Fiscal Year: 1999
    The integrin alpha/v/beta6, a receptor for the extracellular matrix proteins fibronectin and tenascin, is highly expressed in both airway and alveolar epithelium during organogenesis and in response to injury or inflammation...
  32. Expression Profiling of Ehlers-Danlos Fibroblasts
    James Bristow; Fiscal Year: 2003
    ..classical EDS; patients with mutations in C0L3A1 causing vascular type EDS; and patients with mutations in tenascin-X causing a recently described recessive variant of classical EDS...
  33. BIOLOGIC BASES FOR PERIODONTAL TISSUE REGENERATION
    Ikramuddin Aukhil; Fiscal Year: 1999
    ..The extracellular matrix glycoproteins - tenascin (Tn) and fibronectin (Fn) are prominently expressed during embryonic development and wound healing...
  34. DEVELOPMENTAL MORPHOGENETICS OF THE MOUSE DENTITION
    Kenneth Weiss; Fiscal Year: 1993
    ..Similar procedures will be used for Int-2, Collagen I, and tenascin (and closely homologous genes), that are involved in the control of cell differentiation and extra-cellular ..
  35. Neural Stem Cell Proteoglycans
    RICHARD MARGOLIS; Fiscal Year: 2003
    ..g., hyaluronan, tenascin-C, Slit protein)...
  36. CARDIOVASCULAR CALCIFICATION PATHOPHYSIOLOGY & TREATMENT
    Robert Levy; Fiscal Year: 2003
    ..of osteopontin (OPN), an ECM protein associated with calcification inhibition, and down-regulation of tenascin-C (TNC), an ECM protein associated with heart valve calcification...
  37. Dissecting the mechanisms of cell adhesion modulation
    SELWYN WILLIAMS; Fiscal Year: 2006
    ..b>Tenascin-C is an adhesion modulating protein that directly interacts with the heparin-binding domain of FN...
  38. Prx homebox genes in pulmonary vascular homeostasis
    Peter Jones; Fiscal Year: 2006
    ..and thereafter in the media, of hypertensive PAs where they co-localize with the pro-proliferative glycoprotein tenascin-C (TN-C)...
  39. REGULATED EXPRESSION OF TENASCIN AND AVB6 IN ORAL CANCER
    Daniel Ramos; Fiscal Year: 2001
    ..However, other ECM components also play a role. In particular, we and others have observed that tenascin-C (TN-C) expression is upregulated in oral cancer...
  40. GORDON CONFERENCE--FIBRONECTIN AND MACROMOLECULES
    Mark Ginsberg; Fiscal Year: 1993
    ..like fibronectin, laminin, thrombospondin, von Willebrand factor, fibrinogen/fibrin, vitronectin, and cytotactin/tenascin/hexabrachion...
  41. GORDON CONFERENCE ON FIBRONECTIN & RELATED MACROMOLECULE
    MICHAEL PIERSCHBACHER; Fiscal Year: 1991
    ..like fibronectin, laminin, thrombospondin, von Willebrand factor, fibrinogen/fibrin, vitronectin, and cytotactin/tenascin/hexabrachion...
  42. FIBRONECTIN ASSEMBLY, STRUCTURE AND FUNCTION
    JEAN SCHWARZBAUER; Fiscal Year: 2009
    ..Using the fibrin-FN matrix, we have shown dramatic effects on cell morphology and signaling by tenascin contraction, and suppression of Rho GTPase and focal adhesion kinase (FAK) signaling...
  43. STUDIES OF ADULT BRAIN NEUROPOIESIS
    Dennis Steindler; Fiscal Year: 2006
    ..Specific Aim 1 will test the hypothesis that particular extracellular matrix molecules (tenascin-C and chondroitin sulfate proteoglycan), a candidate integrin receptor, cell surface molecules (CD 15 and CD9), ..
  44. STRUCTURAL MECHANISMS OPERATING IN UNRESPONSIVE ASTHMA
    Robert Brown; Fiscal Year: 2003
    ..structural alterations of the airway wall extracellular matrix with the deposition of collagen, fibronectin, and tenascin. Neither the reversibility of these changes nor their functional consequences are well understood...
  45. TENASCIN STRUCTURE AND ROLE IN NEOPLASIA
    MARIO BOURDON; Fiscal Year: 2001
    ..abstract) The overall objectives of this proposed research is to understand the functional interaction of tenascin with its cellular and extracellular receptors and the role of these interactions in neoplastic growth and more ..
  46. Investigation of a sodium channel signaling complex
    TIGWA DAVIS; Fiscal Year: 2004
    ..Specifically, the first aim will identify the domains of tenascin-R responsible for binding to the Nay 1...
  47. EXTRACELLULAR MATRIX AND CELL ATTACHMENT PROTEINS
    HAROLD ERICKSON; Fiscal Year: 2000
    Continued studies will focus primarily on tenascin - the giant hexabrachion molecule in the extracellular matrix of tumors, healing wounds and specific embryonic tissues. We are already making transgenic mice that overexpress tenascin...
  48. Tenascin-C-Fragments for Spinal Cord Regeneration
    ANDREW BLIGHT; Fiscal Year: 2001
    The goal of this project is to conduct pre-clinical tests of components of the extracellular matrix molecule tenascin-C that offer potential as therapeutics for enhancing nerve fiber regeneration...
  49. The Role of Tenascin in Neointimal Formation
    Prediman Shah; Fiscal Year: 2009
    ..Aim 3. TN deficiency promotes neointimal formation after vascular injury. Aim 4. TN deficiency per se is sufficient for neointimal formation. ..
  50. MOLECULAR MECHANISMS OF INVASION IN ORAL CANCER
    Randall Kramer; Fiscal Year: 2001
    ..SCC, using a new cytogenetic method (comparative genomic hybridization), and (2) the role of extracellular matrix tenascin and its receptor (alpha-v-beta-6) in progression of oral SCC, using receptor-null mice...
  51. Gene Expression Pattern of Liver Stem/Progenitor Cells
    Mariana Dabeva; Fiscal Year: 2006
    ..The biological function of different growth factors and the ECM protein tenascin C (for which induced expression in ED13 fetal liver was observed), on maintenance, proliferation and ..
  52. Molecular Genetics Basis of Mammalian Birth Defects
    AMY LOSSIE; Fiscal Year: 2005
    ..Odz4 is one of the four mouse homologs of the Drosophila odd oz/tenascin major (odz/Ten-m) gene, and a member of the Teneurin protein family...
  53. Phase II Study of 44Gy from 131I-81C6 for CNS Tumors
    David Reardon; Fiscal Year: 2004
    ..81C6, a murine IgG2b mAB reacts with an isoform of the extracellular matrix protein tenascin which is highly upregulated and expressed by malignant glioma...
  54. Astatine 211 & Radioiodine Labeled Octreotide Conjugates
    Michael Zalutsky; Fiscal Year: 2004
    ..The proposed in vitro studies include characterization of binding, internalization and catabolism; the proposed in vivo studies include evaluation of tissue distribution, dosimetry, catabolism as well as therapeutic efficacy. ..
  55. ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIES
    Michael Zalutsky; Fiscal Year: 2008
    ..abstract_text> ..
  56. THE FnA D REGION OF TENASCIN C AND NEURONAL GROWTH
    Sally Meiners; Fiscal Year: 2005
    ..This proposal centers upon understanding how the extracellular matrix molecule tenascin-C regulates neuronal growth...
  57. Mentored Patient-Oriented Research Career Development Aw
    David Rizzieri; Fiscal Year: 2004
    ..These results will lead to future improvements in maximizing the anti-tumor effects of allogeneic therapy, hastening immunologic recovery, and minimizing the toxicity of this procedure. ..
  58. Voltage-gated sodium channel beta subunits in zebrafish
    LORI ISOM; Fiscal Year: 2006
    ..abstract_text> ..
  59. RUNX2 AND PPAR-GAMMA IN CHONDROCYTE FUNCTION
    Masahiro Iwamoto; Fiscal Year: 2009
    ..abstract_text> ..
  60. Invasion and Angiogenesis in Malignant Gliomas
    David Zagzag; Fiscal Year: 2008
    ..Results from these experiments will lead to future strategies designed to inhibit specific molecular components implicated in these critical processes. ..
  61. Sodium Channel Beta Subunit Cell Adhesive Interactions
    Lori L Isom; Fiscal Year: 2010
    ....