Genomes and Genes
Summary: Proteins found in any species of protozoan.
Publications373 found, 100 shown here
- The genome of the African trypanosome Trypanosoma bruceiMatthew Berriman
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Science 309:416-22. 2005..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
- Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in childrenThomas Lavstsen
Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, Faculty of Health Sciences, University of Copenhagen, Rigshospitalet, 1014 Copenhagen K, Denmark
Proc Natl Acad Sci U S A 109:E1791-800. 2012..This study specifies the var/PfEMP1 types expressed in severe malaria in children, and thereby provides unique targets for future efforts to prevent and treat severe malaria infections...
- PlasmoDB: a functional genomic database for malaria parasitesCristina Aurrecoechea
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
Nucleic Acids Res 37:D539-43. 2009..Various results can then be combined with each other on the query history page. Search results can be downloaded with associated functional data and registered users can store their query history for future retrieval or analysis...
- Genome sequence of the human malaria parasite Plasmodium falciparumMalcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:498-511. 2002..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
- Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80My Hang Huynh
Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Eukaryot Cell 8:530-9. 2009..LIC constructs reduces both the time and cost required to determine localization of a new gene of interest. This should allow the opportunity for performing larger-scale studies of novel T. gondii genes...
- The cellular and molecular basis for malaria parasite invasion of the human red blood cellAlan F Cowman
The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, 3052, Australia
J Cell Biol 198:961-71. 2012..Significant effort has, therefore, focused on identifying the proteins involved and understanding the underlying mechanisms behind merozoite invasion into the protected niche inside the human erythrocyte...
- TriTrypDB: a functional genomic resource for the TrypanosomatidaeMartin Aslett
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
Nucleic Acids Res 38:D457-62. 2010....
- A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cellsAntoine Claessens
Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Proc Natl Acad Sci U S A 109:E1772-81. 2012..58). This work describes a binding phenotype for virulence-associated group A P. falciparum erythrocyte membrane protein 1 variants and identifies targets for interventions to treat or prevent cerebral malaria...
- CD8+ T effector memory cells protect against liver-stage malariaArturo Reyes-Sandoval
The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
J Immunol 187:1347-57. 2011..Thus, we identify persistent CD8 T(EM) populations as essential for vaccine-induced pre-erythrocytic protection against malaria, a finding that has important implications for vaccine design...
- Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposureC J Drakeley
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Proc Natl Acad Sci U S A 102:5108-13. 2005..Thus, serological tools allow us to detect variations in malaria transmission over time. Such tools will be invaluable for monitoring trends in malaria endemicity and the effectiveness of malaria control programs...
- A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodiesAnja Bengtsson
Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 1014, Denmark
J Immunol 190:240-9. 2013..Our study challenges earlier conclusions that group A PfEMP1 proteins are not central to ICAM-1-specific IE adhesion and support the feasibility of developing a vaccine preventing cerebral malaria by inhibiting cerebral IE sequestration...
- Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasitesAshfaq Ghumra
Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
PLoS Pathog 8:e1002665. 2012..The existence of shared surface epitopes amongst functionally similar disease-associated P. falciparum parasite isolates suggests that development of therapeutic interventions to prevent severe malaria is a realistic goal...
- Structural and functional insights into the malaria parasite moving junction complexBrigitte Vulliez-Le Normand
Unité d Immunologie Structurale, Institut Pasteur, Paris, France
PLoS Pathog 8:e1002755. 2012..These results identify the key residues governing the interactions between AMA1 and RON2 in P. falciparum and suggest novel approaches to antimalarial therapeutics...
- Spiroindolones, a potent compound class for the treatment of malariaMatthias Rottmann
Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH 4002 Basel, Switzerland
Science 329:1175-80. 2010..The optimized spiroindolone NITD609 shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model...
- The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysisFreya J I Fowkes
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
PLoS Med 7:e1000218. 2010..However, published evidence of the protective effect of these antibodies is conflicting...
- Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma bruceiT Nicolai Siegel
Laboratory of Molecular Parasitology, The Rockefeller University, New York, New York 10065, USA
Genes Dev 23:1063-76. 2009....
- Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparumFrancesco Silvestrini
double daggerDipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Mol Cell Proteomics 9:1437-48. 2010..falciparum, probably contributing to host cell remodeling in this phase of the life cycle, and that gametocyte-enriched molecules are recruited to modulate this process in gametocytogenesis...
- A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAsSarah Sebastian
Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
Cell Host Microbe 12:9-19. 2012..These findings indicate that CDPK1 is a multifunctional protein that translationally regulates mRNAs to ensure timely and stage-specific protein expression...
- Improved diagnostic testing and malaria treatment practices in ZambiaDavidson H Hamer
Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
JAMA 297:2227-31. 2007....
- Genetic diversity among Plasmodium falciparum field isolates in Pakistan measured with PCR genotyping of the merozoite surface protein 1 and 2Najia K Ghanchi
Department of Pathology and Microbiology, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
Malar J 9:1. 2010..This study aimed to establish molecular characterization of P. falciparum field isolates in Pakistan measured with two highly polymorphic genetic markers, i.e. the merozoite surface protein 1 (msp-1)and 2 (msp-2)...
- Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein familyJoel H Janes
Department of Global Health, University of Washington, Seattle, Washington, United States of America
PLoS Pathog 7:e1002032. 2011....
- Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasitesDave Richard
Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia
J Biol Chem 285:14815-22. 2010..We propose that the formation of the AMA1-RON complex is essential for secretion of the rhoptry contents, which then allows the establishment of parasite infection within the parasitophorous vacuole...
- Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparumM B Reed
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Nature 403:906-9. 2000..This has important implications for the development and efficacy of future antimalarial agents...
- Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagellaG J Pazour
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Biol 151:709-18. 2000..This indicates that IFT is important for primary cilia assembly in mammals. It is likely that primary cilia have an important function in the kidney and that defects in their assembly can lead to polycystic kidney disease...
- Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparumLev Solyakov
Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, UK
Nat Commun 2:565. 2011..These studies not only reveal processes that are regulated by protein phosphorylation, but also define potential anti-malarial drug targets within the parasite kinome...
- Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoitesMallika Imwong
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
J Infect Dis 195:927-33. 2007..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection...
- Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responsesArturo Reyes-Sandoval
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom
Infect Immun 78:145-53. 2010....
- Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching patternMario Recker
Department of Zoology, University of Oxford, Oxford, United Kingdom
PLoS Pathog 7:e1001306. 2011..falciparum malaria as a balanced process of parasite-intrinsic switching and immune-mediated selection...
- Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigensAndrew R Williams
The Jenner Institute, University of Oxford, Oxford, United Kingdom
PLoS Pathog 8:e1002991. 2012..falciparum antigens and should help to guide the rational development of future multi-antigen vaccines...
- Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosettingInès Vigan-Womas
Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, Paris, France
PLoS Pathog 8:e1002781. 2012....
- Proteomic analysis of a eukaryotic ciliumGregory J Pazour
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Cell Biol 170:103-13. 2005..The flagellum also contains many proteins that are conserved in humans but have not been previously characterized in any organism. The results indicate that flagella are far more complex than previously estimated...
- Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondiiMichael S Behnke
Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, USA
PLoS ONE 5:e12354. 2010....
- Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexaDonatella Giovannini
Institut Pasteur, Unité de Biologie et Génétique du Paludisme, 75724 Paris, France
Cell Host Microbe 10:591-602. 2011..We propose that while the RON proteins act at the TJ, AMA1 mainly functions on the zoite surface to permit correct attachment to the cell, which may facilitate invasion depending on the zoite-cell combination...
- Toxoplasma gondii effectors are master regulators of the inflammatory responseMariane B Melo
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Trends Parasitol 27:487-95. 2011..We speculate that combinations of these effectors present in certain Toxoplasma strains work to maintain an optimal parasite burden in different hosts to ensure parasite transmission...
- Calcium-dependent signaling and kinases in apicomplexan parasitesOliver Billker
The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Cell Host Microbe 5:612-22. 2009..This Review summarizes the pivotal roles that calcium- and cyclic nucleotide-dependent kinases play in unique aspects of parasite biology...
- False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 geneOusmane A Koita
Mali Tulane Tropical Medicine Research Center, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali
Am J Trop Med Hyg 86:194-8. 2012..These findings suggest that the use of HRP2-based RDTs should be reconsidered...
- Molecular cloning and cellular localization of a BiP homologue in Trypanosoma brucei. Divergent ER retention signals in a lower eukaryoteJ D Bangs
Department of Microbiology and Immunology, Stanford School of Medicine, CA 94305 5402
J Cell Sci 105:1101-13. 1993..1989) Biochemistry 28, 6440-6446), indicates that endoplasmic reticulum retrieval signals in trypanosomes may be as divergent and heterogeneous as any seen in the other eukaryotes yet studied...
- EuPathDB: a portal to eukaryotic pathogen databasesCristina Aurrecoechea
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
Nucleic Acids Res 38:D415-9. 2010..Search results are dynamically displayed as the strategy is constructed or modified, and can be downloaded, saved, revised, or shared with other database users...
- Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasitesShailja Singh
Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
PLoS Pathog 6:e1000746. 2010..Signaling pathway components involved in apical organelle discharge may serve as novel targets for drug development since inhibition of microneme and rhoptry secretion can block invasion and limit blood-stage parasite growth...
- Serology: a robust indicator of malaria transmission intensity?Patrick Corran
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine LSHTM, Keppel St, London, WC1E 7HT, UK
Trends Parasitol 23:575-82. 2007..Here we present a suggested methodology, highlight the advantages and shortcomings of serological measurements of malaria transmission and identify areas in which further work is desirable...
- Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparumEllen Yeh
Department of Pathology, Stanford Medical School, Stanford, California, United States of America
PLoS Biol 9:e1001138. 2011..Moreover, apicoplast-minus P. falciparum strains will be a powerful tool for further investigation of apicoplast biology as well as drug and vaccine development...
- Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondiiPeter J Bradley
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 280:34245-58. 2005....
- Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptideMichelle L Tonkin
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
Science 333:463-7. 2011..Besides providing insights into host cell invasion by apicomplexan parasites, the structure offers a basis for designing therapeutics targeting these global pathogens...
- Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasitesJose Juan Lopez-Rubio
Unité de Biologie des Interactions Hôte Parasite, CNRS URA2581, Institut Pasteur, Paris, France
Cell Host Microbe 5:179-90. 2009..Our data point to the existence of perinuclear repressive centers associated with control of expression of malaria parasite genes involved in phenotypic variation and pathogenesis...
- Plasmodium falciparum var gene expression is modified by host immunityGeorge M Warimwe
Kenya Medical Research Institute Wellcome Trust Research Programme, 80108 Kilifi, Kenya
Proc Natl Acad Sci U S A 106:21801-6. 2009..This may help the parasite to adapt effectively to the development of host antibodies through modification of the host-parasite relationship...
- Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patientsTimothy Robinson
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS ONE 6:e23204. 2011..falciparum taken directly from malaria patients provides high quality data useful for drug resistance studies, genomic structural analyses and population genetics, and also robustly represents clonal multiplicity...
- Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malariaThomas M Clausen
Department of Infectious Diseases, Centre for Medical Parasitology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
J Biol Chem 287:23332-45. 2012..Based on these novel PfEMP1 structure-function studies, we have constructed a small VAR2CSA antigen that has the capacity to induce highly adhesion-blocking antibodies...
- Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 responseFabienne Plattner
Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Cell Host Microbe 3:77-87. 2008..Thus, profilin is an essential element of two aspects of T. gondii infection. Like bacterial flagellin, profilin plays a role in motility while serving as a microbial ligand recognized by the host innate immune system...
- Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malariaDamien R Drew
The Burnet Institute for Medical Research and Public Health, Melbourne, Australia
PLoS ONE 7:e51023. 2012..Our findings support the concept that a multi-allele AMA1 vaccine would give broad coverage against the diversity of AMA1 alleles and establish new tools to define polymorphisms important for vaccine escape...
- Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparumWai Hong Tham
Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Vic, Australia
Trends Parasitol 28:23-30. 2012....
- Intracellular parasite invasion strategiesL D Sibley
Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
Science 304:248-53. 2004..Efficient invasion has brought widespread success to this group, which includes Toxoplasma, Plasmodium, and Cryptosporidium...
- Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome speciesAndrew P Jackson
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
Proc Natl Acad Sci U S A 109:3416-21. 2012....
- Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasionPrakash Srinivasan
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
Proc Natl Acad Sci U S A 108:13275-80. 2011..Collectively, these results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON2 as a potential vaccine candidate...
- Draft genome sequencing of giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species?Oscar Franzén
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
PLoS Pathog 5:e1000560. 2009..01% in WB). The genomic differences between WB and GS may explain some of the observed biological and clinical differences between the two isolates, and it suggests that assemblage A and B Giardia can be two different species...
- Prediction of residues in discontinuous B-cell epitopes using protein 3D structuresPernille Haste Andersen
Center for Biological Sequence Analysis, BioCentrum, Technical University of Denmark, DK 2800 Lyngby, Denmark
Protein Sci 15:2558-67. 2006..Predictions by the DiscoTope method can guide experimental epitope mapping in both rational vaccine design and development of diagnostic tools, and may lead to more efficient epitope identification...
- Chloroquine resistance before and after its withdrawal in KenyaLeah Mwai
Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
Malar J 8:106. 2009..Changes to those that occurred in the dihydrofolate reductase gene (dhfr) that confers resistance to the replacement drug, pyrimethamine/sulphadoxine were also compared...
- The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmissionRita Tewari
Institute of Genetics, QMC, University of Nottingham, Nottingham NG7 2UH, UK
Cell Host Microbe 8:377-87. 2010....
- Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illnessDanielle I Stanisic
Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
Infect Immun 77:1165-74. 2009..However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation...
- Dried blood spots as a source of anti-malarial antibodies for epidemiological studiesPatrick H Corran
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Malar J 7:195. 2008..Although recommendations for the storage and analysis of small molecule analytes in blood spots exist, there are no published systematic studies of the stability of antibodies under different storage conditions...
- Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joiningBarbara A Fox
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
Eukaryot Cell 8:520-9. 2009....
- G protein signaling events are activated at the leading edge of chemotactic cellsC A Parent
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cell 95:81-91. 1998....
- Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation methodChristopher J Tonkin
Plant Cell Biology Research Centre, School of Botany, The University of Melbourne, Parkville, VIC 3010, Australia
Mol Biochem Parasitol 137:13-21. 2004..falciparum proteins...
- An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophagesJudith Maxwell Silverman
Department of Medicine, Division of Infectious Diseases, University of British Columbia, Faculties of Medicine and Science, 2733 Heather St, Vancouver, BC V5Z 3J5, Canada
J Cell Sci 123:842-52. 2010..Moreover, we describe a mechanism for the direct delivery of Leishmania molecules into macrophages. These findings suggest that, like mammalian exosomes, Leishmania exosomes function in long-range communication and immune modulation...
- Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genesKarla Pérez-Toledo
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional IPN, Apartado Postal 14 740, 07360, Mexico D F, Mexico
Nucleic Acids Res 37:2596-606. 2009..This is the first report implicating an HP1 protein in the control of antigenic variation of a protozoan parasite...
- Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote developmentGunnar R Mair
Leiden Malaria Research Group, Department of Parasitology, Centre for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
PLoS Pathog 6:e1000767. 2010..Therefore, translational repression may offer avenues as a target for the generation of transmission blocking strategies and contribute to limiting the spread of malaria...
- South American Plasmodium falciparum after the malaria eradication era: clonal population expansion and survival of the fittest hybridsSean M Griffing
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 6:e23486. 2011..Understanding the population substructure of P. falciparum has implications for vaccine, drug, and epidemiologic studies, including monitoring malaria during and after the elimination phase...
- Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasionJeffrey Mital
Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
Mol Biol Cell 16:4341-9. 2005..The data suggest a model in which attachment of the parasite to the host cell occurs in two distinct stages, the second of which requires TgAMA1 and is involved in regulating rhoptry secretion...
- Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasitesSash Lopaticki
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Infect Immun 79:1107-17. 2011..This validates the use of a combination of these ligands as a potential vaccine that would have broad activity against P. falciparum...
- Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparumChristopher J Tonkin
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
PLoS Biol 7:e84. 2009..This work highlights the pivotal but distinct role for both PfSir2 paralogues in epigenetic silencing of P. falciparum virulence genes and the control of pathogenicity of malaria infection...
- Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccinesSimon J Draper
Jenner Institute, University of Oxford, Oxford, OX3 7DQ, United Kingdom
J Immunol 185:7583-95. 2010..These data encourage the further clinical development and coadministration of protein and viral vector vaccine platforms in an attempt to induce broad cellular and humoral immune responses against blood-stage malaria Ags in humans...
- In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)Christin Sisowath
Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
J Infect Dis 191:1014-7. 2005..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
- Therapeutic vaccination with recombinant adenovirus reduces splenic parasite burden in experimental visceral leishmaniasisAsher Maroof
Centre for Immunology and Infection, Hull York Medical School and Department of Biology, University of York, Heslington, UK
J Infect Dis 205:853-63. 2012..These studies indicate the usefulness of adenoviral vectors to deliver leishmanial antigens in a potent and host protective manner to animals with existing L. donovani infection...
- The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasitesMauld Lamarque
UMR 5235 CNRS, Université de Montpellier 2, Montpellier, France
PLoS Pathog 7:e1001276. 2011..gondii and P. falciparum entry into their host cells. This work provides the first evidence that AMA1 uses the rhoptry neck protein RON2 as a receptor to promote invasion by Apicomplexa parasites...
- Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene lociSteven Kelly
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Mol Biochem Parasitol 154:103-9. 2007
- In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in AfricaChristin Sisowath
Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
J Infect Dis 199:750-7. 2009..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
- Genome of the host-cell transforming parasite Theileria annulata compared with T. parvaArnab Pain
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Science 309:131-3. 2005....
- Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth controlBarbara A Butcher
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
PLoS Pathog 7:e1002236. 2011..We conclude that encounter between Toxoplasma ROP16 and the host cell STAT signaling cascade has pleiotropic downstream effects that act in multiple and complex ways to direct the course of infection...
- A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondiiBrooke R Anderson-White
Department of Biology, Boston College, Chestnut Hill, MA, USA
Cell Microbiol 13:18-31. 2011..Furthermore we identified IMC15 as an early marker of budding and, lastly, the dynamic patterns observed throughout cytokinesis provide a timeline for daughter parasite development and division...
- Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complexThomas Nebl
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
PLoS Pathog 7:e1002222. 2011..This suggests that invasion motor activity could be regulated not only by phosphorylation but also by the direct binding of calcium ions to this new component...
- Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trialKwaku Poku Asante
Kintampo Health Research Centre, Kintampo, Ghana
Lancet Infect Dis 11:741-9. 2011..8 month follow-up data have been reported for safety and immunogenicity of RTS,S/AS01(E) when integrated into the EPI. We report extended follow-up to 19 months, including efficacy results...
- Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP componentCindy Tamminga
U S Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
PLoS ONE 6:e25868. 2011..As adenovirus vaccine vectors induce both these responses in humans, a Phase 1/2a clinical trial was conducted to evaluate the efficacy of an adenovirus serotype 5-vectored malaria vaccine against sporozoite challenge...
- Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus AnkaraDaniel P Webster
Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK
Proc Natl Acad Sci U S A 102:4836-41. 2005....
- Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistanceMaria Isabel Veiga
Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e20212. 2011..Our work unveils new candidate markers of P. falciparum multidrug resistance in vitro, while contributing to the understanding of subjacent genetic complexity, essential for future evidence-based drug policy decisions...
- Molecular analysis of pfatp6 and pfmdr1 polymorphisms and their association with in vitro sensitivity in Plasmodium falciparum isolates from the Thai-Myanmar borderPapichaya Phompradit
Thailand Center of Excellence on Drug Discovery and Development, Thammasat University, Rangsit Campus, Patumthani 12121, Thailand
Acta Trop 120:130-5. 2011..No association between mutation or amplification of pfatp6 gene and in vitro susceptibility of P. falciparum isolates was found...
- var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2Letusa Albrecht
Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
Malar J 10:17. 2011..Binding of the pRBC is mediated by Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a large multi-variant molecule encoded by a family of ≈60 var genes...
- A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytesJeffrey D Dvorin
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Science 328:910-2. 2010..The arrest was downstream of cyclic guanosine monophosphate-dependent protein kinase (PfPKG) function and independent of protease processing. Thus, PfCDPK5 plays an essential role during the blood stage of malaria replication...
- Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169Susanne Kramer
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
J Cell Sci 121:3002-14. 2008....
- From the circumsporozoite protein to the RTS, S/AS candidate vaccineJoe Cohen
GlaxoSmithKline Biologicals, Belgium
Hum Vaccin 6:90-6. 2010....
- Apical membrane antigen 1: a malaria vaccine candidate in reviewEdmond J Remarque
Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
Trends Parasitol 24:74-84. 2008..The current understanding of AMA1 will be presented, particularly in relation to the vaccine potential of AMA1 and the approaches being taken towards clinical development...
- Spread and evolution of Plasmodium falciparum drug resistanceToshihiro Mita
Department of International Affairs and Tropical Medicine, Tokyo Women s Medical University, School of Medicine, 9 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
Parasitol Int 58:201-9. 2009....
- A multifunctional serine protease primes the malaria parasite for red blood cell invasionKonstantinos Koussis
Division of Parasitology, National Institute for Medical Research, London, UK
EMBO J 28:725-35. 2009..We propose that PfSUB1 is a multifunctional processing protease with an essential role in both egress of the malaria merozoite and remodelling of its surface in preparation for erythrocyte invasion...
- Functional dissection of the apicomplexan glideosome molecular architectureKarine Frénal
Department of Microbiology and Molecular Medicine, Centre Medical Universitaire, University of Geneva, CH 1211 Geneva 4, Switzerland
Cell Host Microbe 8:343-57. 2010....
- Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemiaJack S Richards
Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, Australia
Clin Infect Dis 51:e50-60. 2010..Erythrocyte-binding antigens (EBAs) are important erythrocyte invasion ligands used by merozoites and may be targets of protective immunity, but there are limited data examining their potential importance...
- Radial spoke proteins of Chlamydomonas flagellaPinfen Yang
Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
J Cell Sci 119:1165-74. 2006..The human genes encoding these proteins are candidates for causing primary ciliary dyskinesia, a severe inherited disease involving missing or defective axonemal structures, including the radial spokes...
- Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytesSharon Yeoh
Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Cell 131:1072-83. 2007..Our findings reveal the presence in the malarial parasitophorous vacuole of a regulated, PfSUB1-mediated proteolytic processing event required for release of viable parasites from the host erythrocyte...
- Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complexBen J Mans
National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20892, USA
Cell Cycle 3:1612-37. 2004..A primitive NPC with approximately 20 proteins and a Src1p-Man1-like membrane protein with a DNA-tethering HEH domain are inferred to have been integral perinuclear components in the las common ancestor of modern eukaryotes...
- A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biologyChristian Flueck
Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, University of Basel, Basel, Switzerland
PLoS Pathog 6:e1000784. 2010..These findings are highly relevant for our understanding of chromosome end biology and variegated expression in P. falciparum and other eukaryotes, and for the future analysis of the role of ApiAP2-DNA interactions in parasite biology...
- Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trialAlly Olotu
Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
Lancet Infect Dis 11:102-9. 2011..We recently showed efficacy against clinical falciparum malaria in 5-17 month old children, during an average of 8 months follow-up. We aimed to assess the efficacy of RTS,S/AS01E during 15 months of follow-up...
- Intraflagellar transport (IFT) protein IFT25 is a phosphoprotein component of IFT complex B and physically interacts with IFT27 in ChlamydomonasZhaohui Wang
Department of Biology, Texas A and M University, College Station, Texas, USA
PLoS ONE 4:e5384. 2009..The function of IFT proteins in flagellar assembly has been extensively investigated. However, much less is known about the molecular mechanism of how IFT is regulated...
- Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machineryJan Mani
Institute of Cell Biology, University of Bern, Bern, Switzerland
PLoS ONE 6:e22463. 2011..Our results are also consistent with stage-specific regulation of translation in trypanosomes, but most likely in the context of initiation...
- The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complexJessica S Tyler
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Pathog 7:e1001282. 2011..Hence, the entire C-terminal region of TgRON2 forms the crucial bridge between TgAMA1 and the rest of the MJ complex but this association is not required for rhoptry protein injection...
- Translation Research in Plasmodium vivaxSocrates Herrera; Fiscal Year: 2005..abstract_text> ..
- Cryptosporidium parvum Histone DeacetylasesSTANLEY RIDER; Fiscal Year: 2007..There are currently no highly effective treatments for Cryptosporidium parvum. This research is a beginning step toward identifying novel methods to control this parasite. [unreadable] [unreadable] [unreadable]..
- DRUG-RESISTANT MALARIA IN MALAWICHRISTOPHER PLOWE; Fiscal Year: 2002..abstract_text> ..
- Randomized, controlled trial of daily trimethoprim-sulfamethoxazole or weekly chlCHRISTOPHER PLOWE; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWICHRISTOPHER PLOWE; Fiscal Year: 2007..unreadable] [unreadable]..
- TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWICHRISTOPHER PLOWE; Fiscal Year: 2003....
- RNA Uridylytransferases of TrypanosomesRuslan Aphasizhev; Fiscal Year: 2009..Sequences of the newly identified UTP-specific transferases will be used to establish characteristic protein motifs for this family of enzymes. ..
- Modular design of central metabolism in methylotrophsGregory Crowther; Fiscal Year: 2006..abstract_text> ..
- EXPANDED PROTEIN STRUCTURE REFINEMENT AND VALIDATIONEthan Merritt; Fiscal Year: 2005..This, in turn, will make it easier to identify key biological features such as the presence and conformation of bound ligands, and the nature of hinge and inter-domain motions. ..
- Gut Epithelial Cell Receptors for C parvum InvasionROBERTA O CONNOR; Fiscal Year: 2005..New England Medical Center, in association with Tufts University and the wider Boston scientific community provides researchers with diverse and excellent scientific resources, and is exceptional environment for a young scientist...
- Role of Cryptosporidium Mucins in Host-parasite interactionsROBERTA O CONNOR; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Software tools for analysis and visulaization of protein structureEthan A Merritt; Fiscal Year: 2010..The algorithms and computation tools developed as part of this work will be distributed freely, and we will provide web-based state of the art analysis of structures submitted by external researchers. ..
- MOLECULAR EVOLUTION OF P. FALCIPARUM AND P VIVAXAnanias Escalante; Fiscal Year: 2003....
- A randomized, controlled clinical trial of chloroquine as chemoprophylaxis versusMIRIAM LAUFER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Plasmodium vivax recombinant CS protein vaccineB Sim; Fiscal Year: 2006..abstract_text> ..
- High Throughput Analysis of Malarial Surface AntigensANDREW OLEINIKOV; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- APEs as novel drug targets in AIDS opportunistic pathogen ToxoplasmaWILLIAM SULLIVAN JR; Fiscal Year: 2008..Moreover, Toxoplasma can be informative as a model organism to study Plasmodium, the causative agent of malaria. [unreadable] [unreadable] [unreadable] [unreadable]..
- Analysis of the Plasmodium merozoite rhoptry proteomeTOBILI SAM YELLOWE; Fiscal Year: 2006..2) We will analyze rhoptries during schizont development by MudPIT analysis and evaluate the distribution of rhoptry proteins during rhoptry biogenesis. [unreadable] [unreadable]..
- KNEE STABILITY TRAINING IN INDIVDUALS WITH KNEE OSTEOARTHRITISG Fitzgerald; Fiscal Year: 2007....
- Evaluation of High-Capacity Adenovectors in the EyeJoseph Bruder; Fiscal Year: 2006..The long-term goal of this proposal is the clinical testing and commercialization of PEDF expressing HC vector for the treatment of AMD and other ocular neovascular diseases. [unreadable] [unreadable]..
- GCN5-mediated transcription in AIDS pathogen ToxoplasmaWILLIAM SULLIVAN JR; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Targeting Cysteine Proteases: Antiparasitic ChemotherapyJames McKerrow; Fiscal Year: 2008..No Abstract Provided. ..
- Gene Expression in Trichomonas vaginalisPatricia Johnson; Fiscal Year: 2008..Additionally, they will provide critical information on pivotal properties of gene expression that might lead to possible therapeutic applications. ..
- Role of dendritic cells in resistance to Toxoplasma.Christopher A Hunter; Fiscal Year: 2010..gondii and their contribution to the development of innate and adaptive mechanisms of resistance to this pathogen. ..
- New Approaches to Schistosome vaccine antigen discoveryChristopher King; Fiscal Year: 2008..An effective vaccine could transform control programs for schistosomiasis by reducing the costs of repeated treatment, and the risk of developing drug resistance. ..
- BIOGENESIS OF HYDROGENOSOMES OF A TRICHOMONAD PARASITEPatricia Johnson; Fiscal Year: 2003..This detailed analysis will provide valuable insights into the origin and biogenesis of hydrogenosomes and information of potential chemotherapeutic importance. ..
- Confocal Microscope for MicrobiologyL Sibley; Fiscal Year: 2002..This instrument will greatly strengthen the research programs of these highly productive groups by applying high-resolution confocal microscopy to the study of human pathogens...
- Immunologic interaction of schistomiasis & acute malariaKirsten Lyke; Fiscal Year: 2005..abstract_text> ..
- REGULATION OF THE ERYTHROPOIETIN GENEH Bunn; Fiscal Year: 2003..These studies should provide unique and highly relevant information about common mechanisms of oxygen sensing, signal transduction and gene regulation that enable organisms to adapt to hypoxia. ..
- Role of NFKB in resistance to Toxoplasma gondiiChristopher Hunter; Fiscal Year: 2005....
- REGULATION OF DEVELOPMENT BY PHOSPHORELAY SIGNALINGCHARLES SINGLETON; Fiscal Year: 2002..Finally genetic screens for suppressers or synthetic phenotypes will identify new and perhaps novel components of the regulatory pathway, including upstream inputs, phosphorelay regulators, and downstream effectors. ..
- Mucosal Immunity to Toxoplasma gondiiL Sibley; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- GENE DISCOVERY IN TOXOPLASMA GONDIIL Sibley; Fiscal Year: 2003..In combination with the genetic tools available in T. gondii, this will greatly accelerate investigations into the complex developmental biology of apicomplexan parasites. ..
- A new family of secreted adhesive proteins in PlasmodiumTHOMAS TEMPLETON; Fiscal Year: 2008....
- MOLECULAR ANALYSIS OF THE GLYCOSOME.Marilyn Parsons; Fiscal Year: 2004..Their studies are aimed at understanding glycosomal biogenesis and protein input and the relationship of these processes and the molecules involved to peroxisome biogenesis in the human host. ..
- Forward Genetics in Tetrahymena: Cloning by ComplementationROBERT COYNE; Fiscal Year: 2008..Numerous other basic studies with far-reaching relevance to human health would be facilitated by the availability of the proposed freely available resource. [unreadable] [unreadable] [unreadable] [unreadable]..
- Enzyme Targets-Sterol Synthesis-Opportunistic PathogensWILLIAM NES; Fiscal Year: 2004..The results from these studies will facilitate the design of therapeutic strategies aimed to provide species-specific discrimination of inhibition in the ergosterol biosynthetic pathway. ..
- OXYGEN SENSING AND SIGNAL TRANSDUCTIONH Bunn; Fiscal Year: 2003..abstract_text> ..
- Role of Macrophage Arginase in Anti-Bacterial ImmunityPeter Murray; Fiscal Year: 2009..The outcomes of the proposed studies will reveal new elements of Arg I function and provide rationale for approaching Arg I as a target in inflammatory diseases. ..
- Developing a Measure of Brain Insults In Kenyan ChildrenPenny Holding; Fiscal Year: 2004..The longer-term objective is to provide scientists in East Africa with a rigorously developed methodology for the investigation of the sequelae of brain disorders of pre-natal and peri-natal origin. ..
- PROTEIN PHOSPHORYLATION IN TRYPANOSOMESMarilyn Parsons; Fiscal Year: 2010..Together these studies will signficantly expand our knowledge of the network of signaling interactions in trypanosomes, with the goal of identifying new drug and vaccine targets. ..
- THE PHYSIOLOGY OF DRUG RESISTANT MALARIAPAUL ROEPE; Fiscal Year: 2009..Knowledge gained during this research will significantly expand our understanding of malarial parasite physiology and antimalarial drug resistance. ..
- A SARS-CoV Spike Protein VaccineB Sim; Fiscal Year: 2005..abstract_text> ..
- A Tetravalent Dengue Recombinanat Protein VaccineB Sim; Fiscal Year: 2005..abstract_text> ..
- Adherence of malaria-infected red cellsAlan Cowman; Fiscal Year: 2009..These studies will contribute to and increased understanding of the pathophysiology of falciparum malaria. ..
- Trichomonas vaginalis: Molecular Analysis of AdherenceJOHN ALDERETE; Fiscal Year: 2007..abstract_text> ..
- Role of SOCS proteins in host-pathogen responsesPeter Murray; Fiscal Year: 2003..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
- Calcium ATPases in Apicomplexan Parasites as Potential DL Sibley; Fiscal Year: 2006..Knowledge gained through these studies may improve the ability to pharmacologically inhibit key calcium regulatory enzymes and hence block motility and invasion by this important group of parasites. ..
- Toxoplasma Gondii Regulation of Host Gene ExpressionIra Blader; Fiscal Year: 2004..abstract_text> ..
- Anti-Trypanosomal Agents from a Neotropical CloudforestWILLIAM SETZER; Fiscal Year: 2004..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
- A NOVEL MICROTUBULE-ASSOCIATED PROTEIN IN TRYPANOSOMESKENT HILL; Fiscal Year: 2002....
- Biochemical and Functional Analysis of TrypaninKENT HILL; Fiscal Year: 2007..Therefore, in addition to addressing fundamental questions in cell biology, this research directly impacts efforts to understand and treat infectious diseases and genetic diseases in humans. ..
- Immunoglobulin Allotypes in Hepatitis C Virus InfectionJANARDAN PANDEY; Fiscal Year: 2008..Results of this investigation will advance our understanding of the role of host genetic factors in clearance and persistence of hepatitis C virus infection. ..
- Molecular epidemiology of drug resistant malariaMIRIAM LAUFER; Fiscal Year: 2008..abstract_text> ..
- CORE GRANT FOR VISION RESEARCHNoorjahan Panjwani; Fiscal Year: 2005..abstract_text> ..
- Antigenic Variation and Drug Resistance In P. falciparumQin Cheng; Fiscal Year: 2006..The project has the potential to benefit the health of a substantial proportion of the world's population. ..
- The Role of Selectin-Mediated Recognition in GlaucomaNoorjahan Panjwani; Fiscal Year: 2006..The proposed studies will determine whether the selectin-based carbohydrate recognition system plays a role in the pathogenic mechanisms of aqueous outflow resistance in glaucoma. ..
- Topoisomerases: Target for Antitrypanosomal TherapyTheresa Shapiro; Fiscal Year: 2006..Compounds that appear most promising will be evaluated in mice. These studies take a multi-faceted, rational, and tangible approach to the development of much-needed new anti-trypanosomal chemotherapy. ..
- High Throughput Assay for Screening Compounds(RMI)James McKerrow; Fiscal Year: 2005..Computational and informatics capability is in place to acquire, store and cross-reference this data, and provide access to the scientific community through an open-source website. ..
- Genetics & Population Structure of Plasmodium falciparumStephen Rich; Fiscal Year: 2007..This work will increase our understanding of the genomic evolution of this parasite will yield valuable information for evaluating appropriate strategies for intervening in disease transmission. ..
- BORRELIA EVOLUTION AND POPULATION STRUCTUREStephen Rich; Fiscal Year: 2004..abstract_text> ..
- Trypanosomatid Mitochondrial DNA PolymerasesMichele Klingbeil; Fiscal Year: 2008..The T. brucei pol I-like protein family also offers the unique opportunity to uncover insights into the evolutionary strategies used to produce a replicative polymerase. ..
- SWITCHING IN THE ORAL COMMENSAL CANDIDA GLABRATADavid Soll; Fiscal Year: 2006..abstract_text> ..
- Switching and Candida Pathogenesis-A Molecular AnalysisDavid Soll; Fiscal Year: 2005..The first three aims have been formulated so that they provide several independent starting points for a reverse genetic approach for elucidating switch loci and the switching mechanism. ..
- Host Protein Degradation by Schistosome ParasitesJames McKerrow; Fiscal Year: 2007..abstract_text> ..