protozoan proteins

Summary

Summary: Proteins found in any species of protozoan.

Top Publications

  1. ncbi The genome of the African trypanosome Trypanosoma brucei
    Matthew Berriman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Science 309:416-22. 2005
  2. pmc Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children
    Thomas Lavstsen
    Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, Faculty of Health Sciences, University of Copenhagen, Rigshospitalet, 1014 Copenhagen K, Denmark
    Proc Natl Acad Sci U S A 109:E1791-800. 2012
  3. pmc PlasmoDB: a functional genomic database for malaria parasites
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 37:D539-43. 2009
  4. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
  5. pmc Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80
    My Hang Huynh
    Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Eukaryot Cell 8:530-9. 2009
  6. pmc The cellular and molecular basis for malaria parasite invasion of the human red blood cell
    Alan F Cowman
    The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, 3052, Australia
    J Cell Biol 198:961-71. 2012
  7. pmc TriTrypDB: a functional genomic resource for the Trypanosomatidae
    Martin Aslett
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 38:D457-62. 2010
  8. pmc A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells
    Antoine Claessens
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 109:E1772-81. 2012
  9. ncbi CD8+ T effector memory cells protect against liver-stage malaria
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:1347-57. 2011
  10. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005

Research Grants

  1. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2005
  2. Cryptosporidium parvum Histone Deacetylases
    STANLEY RIDER; Fiscal Year: 2007
  3. DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2002
  4. Randomized, controlled trial of daily trimethoprim-sulfamethoxazole or weekly chl
    CHRISTOPHER PLOWE; Fiscal Year: 2008
  5. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2007
  6. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
  7. RNA Uridylytransferases of Trypanosomes
    Ruslan Aphasizhev; Fiscal Year: 2009
  8. Modular design of central metabolism in methylotrophs
    Gregory Crowther; Fiscal Year: 2006
  9. EXPANDED PROTEIN STRUCTURE REFINEMENT AND VALIDATION
    Ethan Merritt; Fiscal Year: 2005
  10. Gut Epithelial Cell Receptors for C parvum Invasion
    ROBERTA O CONNOR; Fiscal Year: 2005

Detail Information

Publications373 found, 100 shown here

  1. ncbi The genome of the African trypanosome Trypanosoma brucei
    Matthew Berriman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Science 309:416-22. 2005
    ..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
  2. pmc Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children
    Thomas Lavstsen
    Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, Faculty of Health Sciences, University of Copenhagen, Rigshospitalet, 1014 Copenhagen K, Denmark
    Proc Natl Acad Sci U S A 109:E1791-800. 2012
    ..This study specifies the var/PfEMP1 types expressed in severe malaria in children, and thereby provides unique targets for future efforts to prevent and treat severe malaria infections...
  3. pmc PlasmoDB: a functional genomic database for malaria parasites
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 37:D539-43. 2009
    ..Various results can then be combined with each other on the query history page. Search results can be downloaded with associated functional data and registered users can store their query history for future retrieval or analysis...
  4. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    ..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
  5. pmc Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80
    My Hang Huynh
    Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Eukaryot Cell 8:530-9. 2009
    ..LIC constructs reduces both the time and cost required to determine localization of a new gene of interest. This should allow the opportunity for performing larger-scale studies of novel T. gondii genes...
  6. pmc The cellular and molecular basis for malaria parasite invasion of the human red blood cell
    Alan F Cowman
    The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, 3052, Australia
    J Cell Biol 198:961-71. 2012
    ..Significant effort has, therefore, focused on identifying the proteins involved and understanding the underlying mechanisms behind merozoite invasion into the protected niche inside the human erythrocyte...
  7. pmc TriTrypDB: a functional genomic resource for the Trypanosomatidae
    Martin Aslett
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 38:D457-62. 2010
    ....
  8. pmc A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells
    Antoine Claessens
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 109:E1772-81. 2012
    ..58). This work describes a binding phenotype for virulence-associated group A P. falciparum erythrocyte membrane protein 1 variants and identifies targets for interventions to treat or prevent cerebral malaria...
  9. ncbi CD8+ T effector memory cells protect against liver-stage malaria
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:1347-57. 2011
    ..Thus, we identify persistent CD8 T(EM) populations as essential for vaccine-induced pre-erythrocytic protection against malaria, a finding that has important implications for vaccine design...
  10. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005
    ..Thus, serological tools allow us to detect variations in malaria transmission over time. Such tools will be invaluable for monitoring trends in malaria endemicity and the effectiveness of malaria control programs...
  11. pmc A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies
    Anja Bengtsson
    Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 1014, Denmark
    J Immunol 190:240-9. 2013
    ..Our study challenges earlier conclusions that group A PfEMP1 proteins are not central to ICAM-1-specific IE adhesion and support the feasibility of developing a vaccine preventing cerebral malaria by inhibiting cerebral IE sequestration...
  12. pmc Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites
    Ashfaq Ghumra
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Pathog 8:e1002665. 2012
    ..The existence of shared surface epitopes amongst functionally similar disease-associated P. falciparum parasite isolates suggests that development of therapeutic interventions to prevent severe malaria is a realistic goal...
  13. pmc Structural and functional insights into the malaria parasite moving junction complex
    Brigitte Vulliez-Le Normand
    Unité d Immunologie Structurale, Institut Pasteur, Paris, France
    PLoS Pathog 8:e1002755. 2012
    ..These results identify the key residues governing the interactions between AMA1 and RON2 in P. falciparum and suggest novel approaches to antimalarial therapeutics...
  14. pmc Spiroindolones, a potent compound class for the treatment of malaria
    Matthias Rottmann
    Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH 4002 Basel, Switzerland
    Science 329:1175-80. 2010
    ..The optimized spiroindolone NITD609 shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model...
  15. pmc The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis
    Freya J I Fowkes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Med 7:e1000218. 2010
    ..However, published evidence of the protective effect of these antibodies is conflicting...
  16. pmc Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei
    T Nicolai Siegel
    Laboratory of Molecular Parasitology, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 23:1063-76. 2009
    ....
  17. pmc Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparum
    Francesco Silvestrini
    double daggerDipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Mol Cell Proteomics 9:1437-48. 2010
    ..falciparum, probably contributing to host cell remodeling in this phase of the life cycle, and that gametocyte-enriched molecules are recruited to modulate this process in gametocytogenesis...
  18. pmc A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs
    Sarah Sebastian
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Cell Host Microbe 12:9-19. 2012
    ..These findings indicate that CDPK1 is a multifunctional protein that translationally regulates mRNAs to ensure timely and stage-specific protein expression...
  19. pmc Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
    ....
  20. pmc Genetic diversity among Plasmodium falciparum field isolates in Pakistan measured with PCR genotyping of the merozoite surface protein 1 and 2
    Najia K Ghanchi
    Department of Pathology and Microbiology, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Malar J 9:1. 2010
    ..This study aimed to establish molecular characterization of P. falciparum field isolates in Pakistan measured with two highly polymorphic genetic markers, i.e. the merozoite surface protein 1 (msp-1)and 2 (msp-2)...
  21. pmc Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family
    Joel H Janes
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 7:e1002032. 2011
    ....
  22. pmc Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites
    Dave Richard
    Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia
    J Biol Chem 285:14815-22. 2010
    ..We propose that the formation of the AMA1-RON complex is essential for secretion of the rhoptry contents, which then allows the establishment of parasite infection within the parasitophorous vacuole...
  23. ncbi Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
    M B Reed
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Nature 403:906-9. 2000
    ..This has important implications for the development and efficacy of future antimalarial agents...
  24. pmc Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    G J Pazour
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biol 151:709-18. 2000
    ..This indicates that IFT is important for primary cilia assembly in mammals. It is likely that primary cilia have an important function in the kidney and that defects in their assembly can lead to polycystic kidney disease...
  25. ncbi Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum
    Lev Solyakov
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, UK
    Nat Commun 2:565. 2011
    ..These studies not only reveal processes that are regulated by protein phosphorylation, but also define potential anti-malarial drug targets within the parasite kinome...
  26. ncbi Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 195:927-33. 2007
    ..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection...
  27. pmc Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom
    Infect Immun 78:145-53. 2010
    ....
  28. pmc Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern
    Mario Recker
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 7:e1001306. 2011
    ..falciparum malaria as a balanced process of parasite-intrinsic switching and immune-mediated selection...
  29. pmc Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens
    Andrew R Williams
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 8:e1002991. 2012
    ..falciparum antigens and should help to guide the rational development of future multi-antigen vaccines...
  30. pmc Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosetting
    Inès Vigan-Womas
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, Paris, France
    PLoS Pathog 8:e1002781. 2012
    ....
  31. pmc Proteomic analysis of a eukaryotic cilium
    Gregory J Pazour
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 170:103-13. 2005
    ..The flagellum also contains many proteins that are conserved in humans but have not been previously characterized in any organism. The results indicate that flagella are far more complex than previously estimated...
  32. pmc Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii
    Michael S Behnke
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, USA
    PLoS ONE 5:e12354. 2010
    ....
  33. ncbi Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa
    Donatella Giovannini
    Institut Pasteur, Unité de Biologie et Génétique du Paludisme, 75724 Paris, France
    Cell Host Microbe 10:591-602. 2011
    ..We propose that while the RON proteins act at the TJ, AMA1 mainly functions on the zoite surface to permit correct attachment to the cell, which may facilitate invasion depending on the zoite-cell combination...
  34. pmc Toxoplasma gondii effectors are master regulators of the inflammatory response
    Mariane B Melo
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Trends Parasitol 27:487-95. 2011
    ..We speculate that combinations of these effectors present in certain Toxoplasma strains work to maintain an optimal parasite burden in different hosts to ensure parasite transmission...
  35. pmc Calcium-dependent signaling and kinases in apicomplexan parasites
    Oliver Billker
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Cell Host Microbe 5:612-22. 2009
    ..This Review summarizes the pivotal roles that calcium- and cyclic nucleotide-dependent kinases play in unique aspects of parasite biology...
  36. pmc False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene
    Ousmane A Koita
    Mali Tulane Tropical Medicine Research Center, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 86:194-8. 2012
    ..These findings suggest that the use of HRP2-based RDTs should be reconsidered...
  37. ncbi Molecular cloning and cellular localization of a BiP homologue in Trypanosoma brucei. Divergent ER retention signals in a lower eukaryote
    J D Bangs
    Department of Microbiology and Immunology, Stanford School of Medicine, CA 94305 5402
    J Cell Sci 105:1101-13. 1993
    ..1989) Biochemistry 28, 6440-6446), indicates that endoplasmic reticulum retrieval signals in trypanosomes may be as divergent and heterogeneous as any seen in the other eukaryotes yet studied...
  38. pmc EuPathDB: a portal to eukaryotic pathogen databases
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 38:D415-9. 2010
    ..Search results are dynamically displayed as the strategy is constructed or modified, and can be downloaded, saved, revised, or shared with other database users...
  39. pmc Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites
    Shailja Singh
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS Pathog 6:e1000746. 2010
    ..Signaling pathway components involved in apical organelle discharge may serve as novel targets for drug development since inhibition of microneme and rhoptry secretion can block invasion and limit blood-stage parasite growth...
  40. ncbi Serology: a robust indicator of malaria transmission intensity?
    Patrick Corran
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine LSHTM, Keppel St, London, WC1E 7HT, UK
    Trends Parasitol 23:575-82. 2007
    ..Here we present a suggested methodology, highlight the advantages and shortcomings of serological measurements of malaria transmission and identify areas in which further work is desirable...
  41. pmc Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum
    Ellen Yeh
    Department of Pathology, Stanford Medical School, Stanford, California, United States of America
    PLoS Biol 9:e1001138. 2011
    ..Moreover, apicoplast-minus P. falciparum strains will be a powerful tool for further investigation of apicoplast biology as well as drug and vaccine development...
  42. ncbi Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii
    Peter J Bradley
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:34245-58. 2005
    ....
  43. ncbi Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide
    Michelle L Tonkin
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    Science 333:463-7. 2011
    ..Besides providing insights into host cell invasion by apicomplexan parasites, the structure offers a basis for designing therapeutics targeting these global pathogens...
  44. ncbi Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites
    Jose Juan Lopez-Rubio
    Unité de Biologie des Interactions Hôte Parasite, CNRS URA2581, Institut Pasteur, Paris, France
    Cell Host Microbe 5:179-90. 2009
    ..Our data point to the existence of perinuclear repressive centers associated with control of expression of malaria parasite genes involved in phenotypic variation and pathogenesis...
  45. pmc Plasmodium falciparum var gene expression is modified by host immunity
    George M Warimwe
    Kenya Medical Research Institute Wellcome Trust Research Programme, 80108 Kilifi, Kenya
    Proc Natl Acad Sci U S A 106:21801-6. 2009
    ..This may help the parasite to adapt effectively to the development of host antibodies through modification of the host-parasite relationship...
  46. pmc Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients
    Timothy Robinson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e23204. 2011
    ..falciparum taken directly from malaria patients provides high quality data useful for drug resistance studies, genomic structural analyses and population genetics, and also robustly represents clonal multiplicity...
  47. pmc Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria
    Thomas M Clausen
    Department of Infectious Diseases, Centre for Medical Parasitology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 287:23332-45. 2012
    ..Based on these novel PfEMP1 structure-function studies, we have constructed a small VAR2CSA antigen that has the capacity to induce highly adhesion-blocking antibodies...
  48. ncbi Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response
    Fabienne Plattner
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Cell Host Microbe 3:77-87. 2008
    ..Thus, profilin is an essential element of two aspects of T. gondii infection. Like bacterial flagellin, profilin plays a role in motility while serving as a microbial ligand recognized by the host innate immune system...
  49. pmc Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria
    Damien R Drew
    The Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    PLoS ONE 7:e51023. 2012
    ..Our findings support the concept that a multi-allele AMA1 vaccine would give broad coverage against the diversity of AMA1 alleles and establish new tools to define polymorphisms important for vaccine escape...
  50. ncbi Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum
    Wai Hong Tham
    Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Vic, Australia
    Trends Parasitol 28:23-30. 2012
    ....
  51. ncbi Intracellular parasite invasion strategies
    L D Sibley
    Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 304:248-53. 2004
    ..Efficient invasion has brought widespread success to this group, which includes Toxoplasma, Plasmodium, and Cryptosporidium...
  52. pmc Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 109:3416-21. 2012
    ....
  53. pmc Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:13275-80. 2011
    ..Collectively, these results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON2 as a potential vaccine candidate...
  54. pmc Draft genome sequencing of giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species?
    Oscar Franzén
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    PLoS Pathog 5:e1000560. 2009
    ..01% in WB). The genomic differences between WB and GS may explain some of the observed biological and clinical differences between the two isolates, and it suggests that assemblage A and B Giardia can be two different species...
  55. pmc Prediction of residues in discontinuous B-cell epitopes using protein 3D structures
    Pernille Haste Andersen
    Center for Biological Sequence Analysis, BioCentrum, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Protein Sci 15:2558-67. 2006
    ..Predictions by the DiscoTope method can guide experimental epitope mapping in both rational vaccine design and development of diagnostic tools, and may lead to more efficient epitope identification...
  56. pmc Chloroquine resistance before and after its withdrawal in Kenya
    Leah Mwai
    Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
    Malar J 8:106. 2009
    ..Changes to those that occurred in the dihydrofolate reductase gene (dhfr) that confers resistance to the replacement drug, pyrimethamine/sulphadoxine were also compared...
  57. pmc The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission
    Rita Tewari
    Institute of Genetics, QMC, University of Nottingham, Nottingham NG7 2UH, UK
    Cell Host Microbe 8:377-87. 2010
    ....
  58. pmc Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness
    Danielle I Stanisic
    Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Infect Immun 77:1165-74. 2009
    ..However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation...
  59. pmc Dried blood spots as a source of anti-malarial antibodies for epidemiological studies
    Patrick H Corran
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Malar J 7:195. 2008
    ..Although recommendations for the storage and analysis of small molecule analytes in blood spots exist, there are no published systematic studies of the stability of antibodies under different storage conditions...
  60. pmc Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Eukaryot Cell 8:520-9. 2009
    ....
  61. ncbi G protein signaling events are activated at the leading edge of chemotactic cells
    C A Parent
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 95:81-91. 1998
    ....
  62. ncbi Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method
    Christopher J Tonkin
    Plant Cell Biology Research Centre, School of Botany, The University of Melbourne, Parkville, VIC 3010, Australia
    Mol Biochem Parasitol 137:13-21. 2004
    ..falciparum proteins...
  63. ncbi An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages
    Judith Maxwell Silverman
    Department of Medicine, Division of Infectious Diseases, University of British Columbia, Faculties of Medicine and Science, 2733 Heather St, Vancouver, BC V5Z 3J5, Canada
    J Cell Sci 123:842-52. 2010
    ..Moreover, we describe a mechanism for the direct delivery of Leishmania molecules into macrophages. These findings suggest that, like mammalian exosomes, Leishmania exosomes function in long-range communication and immune modulation...
  64. pmc Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes
    Karla Pérez-Toledo
    Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional IPN, Apartado Postal 14 740, 07360, Mexico D F, Mexico
    Nucleic Acids Res 37:2596-606. 2009
    ..This is the first report implicating an HP1 protein in the control of antigenic variation of a protozoan parasite...
  65. pmc Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development
    Gunnar R Mair
    Leiden Malaria Research Group, Department of Parasitology, Centre for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Pathog 6:e1000767. 2010
    ..Therefore, translational repression may offer avenues as a target for the generation of transmission blocking strategies and contribute to limiting the spread of malaria...
  66. pmc South American Plasmodium falciparum after the malaria eradication era: clonal population expansion and survival of the fittest hybrids
    Sean M Griffing
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e23486. 2011
    ..Understanding the population substructure of P. falciparum has implications for vaccine, drug, and epidemiologic studies, including monitoring malaria during and after the elimination phase...
  67. pmc Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion
    Jeffrey Mital
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA
    Mol Biol Cell 16:4341-9. 2005
    ..The data suggest a model in which attachment of the parasite to the host cell occurs in two distinct stages, the second of which requires TgAMA1 and is involved in regulating rhoptry secretion...
  68. pmc Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites
    Sash Lopaticki
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Infect Immun 79:1107-17. 2011
    ..This validates the use of a combination of these ligands as a potential vaccine that would have broad activity against P. falciparum...
  69. pmc Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum
    Christopher J Tonkin
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    PLoS Biol 7:e84. 2009
    ..This work highlights the pivotal but distinct role for both PfSir2 paralogues in epigenetic silencing of P. falciparum virulence genes and the control of pathogenicity of malaria infection...
  70. ncbi Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines
    Simon J Draper
    Jenner Institute, University of Oxford, Oxford, OX3 7DQ, United Kingdom
    J Immunol 185:7583-95. 2010
    ..These data encourage the further clinical development and coadministration of protein and viral vector vaccine platforms in an attempt to induce broad cellular and humoral immune responses against blood-stage malaria Ags in humans...
  71. ncbi In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
    Christin Sisowath
    Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Infect Dis 191:1014-7. 2005
    ..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
  72. pmc Therapeutic vaccination with recombinant adenovirus reduces splenic parasite burden in experimental visceral leishmaniasis
    Asher Maroof
    Centre for Immunology and Infection, Hull York Medical School and Department of Biology, University of York, Heslington, UK
    J Infect Dis 205:853-63. 2012
    ..These studies indicate the usefulness of adenoviral vectors to deliver leishmanial antigens in a potent and host protective manner to animals with existing L. donovani infection...
  73. pmc The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites
    Mauld Lamarque
    UMR 5235 CNRS, Université de Montpellier 2, Montpellier, France
    PLoS Pathog 7:e1001276. 2011
    ..gondii and P. falciparum entry into their host cells. This work provides the first evidence that AMA1 uses the rhoptry neck protein RON2 as a receptor to promote invasion by Apicomplexa parasites...
  74. pmc Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci
    Steven Kelly
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Biochem Parasitol 154:103-9. 2007
  75. pmc In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
    Christin Sisowath
    Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 199:750-7. 2009
    ..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
  76. ncbi Genome of the host-cell transforming parasite Theileria annulata compared with T. parva
    Arnab Pain
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 309:131-3. 2005
    ....
  77. pmc Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control
    Barbara A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    PLoS Pathog 7:e1002236. 2011
    ..We conclude that encounter between Toxoplasma ROP16 and the host cell STAT signaling cascade has pleiotropic downstream effects that act in multiple and complex ways to direct the course of infection...
  78. pmc A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii
    Brooke R Anderson-White
    Department of Biology, Boston College, Chestnut Hill, MA, USA
    Cell Microbiol 13:18-31. 2011
    ..Furthermore we identified IMC15 as an early marker of budding and, lastly, the dynamic patterns observed throughout cytokinesis provide a timeline for daughter parasite development and division...
  79. pmc Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex
    Thomas Nebl
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    PLoS Pathog 7:e1002222. 2011
    ..This suggests that invasion motor activity could be regulated not only by phosphorylation but also by the direct binding of calcium ions to this new component...
  80. ncbi Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial
    Kwaku Poku Asante
    Kintampo Health Research Centre, Kintampo, Ghana
    Lancet Infect Dis 11:741-9. 2011
    ..8 month follow-up data have been reported for safety and immunogenicity of RTS,S/AS01(E) when integrated into the EPI. We report extended follow-up to 19 months, including efficacy results...
  81. pmc Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component
    Cindy Tamminga
    U S Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 6:e25868. 2011
    ..As adenovirus vaccine vectors induce both these responses in humans, a Phase 1/2a clinical trial was conducted to evaluate the efficacy of an adenovirus serotype 5-vectored malaria vaccine against sporozoite challenge...
  82. pmc Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara
    Daniel P Webster
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK
    Proc Natl Acad Sci U S A 102:4836-41. 2005
    ....
  83. pmc Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance
    Maria Isabel Veiga
    Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e20212. 2011
    ..Our work unveils new candidate markers of P. falciparum multidrug resistance in vitro, while contributing to the understanding of subjacent genetic complexity, essential for future evidence-based drug policy decisions...
  84. ncbi Molecular analysis of pfatp6 and pfmdr1 polymorphisms and their association with in vitro sensitivity in Plasmodium falciparum isolates from the Thai-Myanmar border
    Papichaya Phompradit
    Thailand Center of Excellence on Drug Discovery and Development, Thammasat University, Rangsit Campus, Patumthani 12121, Thailand
    Acta Trop 120:130-5. 2011
    ..No association between mutation or amplification of pfatp6 gene and in vitro susceptibility of P. falciparum isolates was found...
  85. pmc var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2
    Letusa Albrecht
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Malar J 10:17. 2011
    ..Binding of the pRBC is mediated by Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a large multi-variant molecule encoded by a family of ≈60 var genes...
  86. pmc A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes
    Jeffrey D Dvorin
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 328:910-2. 2010
    ..The arrest was downstream of cyclic guanosine monophosphate-dependent protein kinase (PfPKG) function and independent of protease processing. Thus, PfCDPK5 plays an essential role during the blood stage of malaria replication...
  87. pmc Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169
    Susanne Kramer
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    J Cell Sci 121:3002-14. 2008
    ....
  88. ncbi From the circumsporozoite protein to the RTS, S/AS candidate vaccine
    Joe Cohen
    GlaxoSmithKline Biologicals, Belgium
    Hum Vaccin 6:90-6. 2010
    ....
  89. ncbi Apical membrane antigen 1: a malaria vaccine candidate in review
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    Trends Parasitol 24:74-84. 2008
    ..The current understanding of AMA1 will be presented, particularly in relation to the vaccine potential of AMA1 and the approaches being taken towards clinical development...
  90. ncbi Spread and evolution of Plasmodium falciparum drug resistance
    Toshihiro Mita
    Department of International Affairs and Tropical Medicine, Tokyo Women s Medical University, School of Medicine, 9 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Parasitol Int 58:201-9. 2009
    ....
  91. pmc A multifunctional serine protease primes the malaria parasite for red blood cell invasion
    Konstantinos Koussis
    Division of Parasitology, National Institute for Medical Research, London, UK
    EMBO J 28:725-35. 2009
    ..We propose that PfSUB1 is a multifunctional processing protease with an essential role in both egress of the malaria merozoite and remodelling of its surface in preparation for erythrocyte invasion...
  92. ncbi Functional dissection of the apicomplexan glideosome molecular architecture
    Karine Frénal
    Department of Microbiology and Molecular Medicine, Centre Medical Universitaire, University of Geneva, CH 1211 Geneva 4, Switzerland
    Cell Host Microbe 8:343-57. 2010
    ....
  93. ncbi Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia
    Jack S Richards
    Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, Australia
    Clin Infect Dis 51:e50-60. 2010
    ..Erythrocyte-binding antigens (EBAs) are important erythrocyte invasion ligands used by merozoites and may be targets of protective immunity, but there are limited data examining their potential importance...
  94. pmc Radial spoke proteins of Chlamydomonas flagella
    Pinfen Yang
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
    J Cell Sci 119:1165-74. 2006
    ..The human genes encoding these proteins are candidates for causing primary ciliary dyskinesia, a severe inherited disease involving missing or defective axonemal structures, including the radial spokes...
  95. ncbi Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes
    Sharon Yeoh
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Cell 131:1072-83. 2007
    ..Our findings reveal the presence in the malarial parasitophorous vacuole of a regulated, PfSUB1-mediated proteolytic processing event required for release of viable parasites from the host erythrocyte...
  96. ncbi Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex
    Ben J Mans
    National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Cycle 3:1612-37. 2004
    ..A primitive NPC with approximately 20 proteins and a Src1p-Man1-like membrane protein with a DNA-tethering HEH domain are inferred to have been integral perinuclear components in the las common ancestor of modern eukaryotes...
  97. pmc A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology
    Christian Flueck
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, University of Basel, Basel, Switzerland
    PLoS Pathog 6:e1000784. 2010
    ..These findings are highly relevant for our understanding of chromosome end biology and variegated expression in P. falciparum and other eukaryotes, and for the future analysis of the role of ApiAP2-DNA interactions in parasite biology...
  98. pmc Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial
    Ally Olotu
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Lancet Infect Dis 11:102-9. 2011
    ..We recently showed efficacy against clinical falciparum malaria in 5-17 month old children, during an average of 8 months follow-up. We aimed to assess the efficacy of RTS,S/AS01E during 15 months of follow-up...
  99. pmc Intraflagellar transport (IFT) protein IFT25 is a phosphoprotein component of IFT complex B and physically interacts with IFT27 in Chlamydomonas
    Zhaohui Wang
    Department of Biology, Texas A and M University, College Station, Texas, USA
    PLoS ONE 4:e5384. 2009
    ..The function of IFT proteins in flagellar assembly has been extensively investigated. However, much less is known about the molecular mechanism of how IFT is regulated...
  100. pmc Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery
    Jan Mani
    Institute of Cell Biology, University of Bern, Bern, Switzerland
    PLoS ONE 6:e22463. 2011
    ..Our results are also consistent with stage-specific regulation of translation in trypanosomes, but most likely in the context of initiation...
  101. pmc The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex
    Jessica S Tyler
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 7:e1001282. 2011
    ..Hence, the entire C-terminal region of TgRON2 forms the crucial bridge between TgAMA1 and the rest of the MJ complex but this association is not required for rhoptry protein injection...

Research Grants65

  1. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2005
    ..abstract_text> ..
  2. Cryptosporidium parvum Histone Deacetylases
    STANLEY RIDER; Fiscal Year: 2007
    ..There are currently no highly effective treatments for Cryptosporidium parvum. This research is a beginning step toward identifying novel methods to control this parasite. [unreadable] [unreadable] [unreadable]..
  3. DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2002
    ..abstract_text> ..
  4. Randomized, controlled trial of daily trimethoprim-sulfamethoxazole or weekly chl
    CHRISTOPHER PLOWE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  5. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
    ....
  7. RNA Uridylytransferases of Trypanosomes
    Ruslan Aphasizhev; Fiscal Year: 2009
    ..Sequences of the newly identified UTP-specific transferases will be used to establish characteristic protein motifs for this family of enzymes. ..
  8. Modular design of central metabolism in methylotrophs
    Gregory Crowther; Fiscal Year: 2006
    ..abstract_text> ..
  9. EXPANDED PROTEIN STRUCTURE REFINEMENT AND VALIDATION
    Ethan Merritt; Fiscal Year: 2005
    ..This, in turn, will make it easier to identify key biological features such as the presence and conformation of bound ligands, and the nature of hinge and inter-domain motions. ..
  10. Gut Epithelial Cell Receptors for C parvum Invasion
    ROBERTA O CONNOR; Fiscal Year: 2005
    ..New England Medical Center, in association with Tufts University and the wider Boston scientific community provides researchers with diverse and excellent scientific resources, and is exceptional environment for a young scientist...
  11. Role of Cryptosporidium Mucins in Host-parasite interactions
    ROBERTA O CONNOR; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Software tools for analysis and visulaization of protein structure
    Ethan A Merritt; Fiscal Year: 2010
    ..The algorithms and computation tools developed as part of this work will be distributed freely, and we will provide web-based state of the art analysis of structures submitted by external researchers. ..
  13. MOLECULAR EVOLUTION OF P. FALCIPARUM AND P VIVAX
    Ananias Escalante; Fiscal Year: 2003
    ....
  14. A randomized, controlled clinical trial of chloroquine as chemoprophylaxis versus
    MIRIAM LAUFER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Plasmodium vivax recombinant CS protein vaccine
    B Sim; Fiscal Year: 2006
    ..abstract_text> ..
  16. High Throughput Analysis of Malarial Surface Antigens
    ANDREW OLEINIKOV; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. APEs as novel drug targets in AIDS opportunistic pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2008
    ..Moreover, Toxoplasma can be informative as a model organism to study Plasmodium, the causative agent of malaria. [unreadable] [unreadable] [unreadable] [unreadable]..
  18. Analysis of the Plasmodium merozoite rhoptry proteome
    TOBILI SAM YELLOWE; Fiscal Year: 2006
    ..2) We will analyze rhoptries during schizont development by MudPIT analysis and evaluate the distribution of rhoptry proteins during rhoptry biogenesis. [unreadable] [unreadable]..
  19. KNEE STABILITY TRAINING IN INDIVDUALS WITH KNEE OSTEOARTHRITIS
    G Fitzgerald; Fiscal Year: 2007
    ....
  20. Evaluation of High-Capacity Adenovectors in the Eye
    Joseph Bruder; Fiscal Year: 2006
    ..The long-term goal of this proposal is the clinical testing and commercialization of PEDF expressing HC vector for the treatment of AMD and other ocular neovascular diseases. [unreadable] [unreadable]..
  21. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Targeting Cysteine Proteases: Antiparasitic Chemotherapy
    James McKerrow; Fiscal Year: 2008
    ..No Abstract Provided. ..
  23. Gene Expression in Trichomonas vaginalis
    Patricia Johnson; Fiscal Year: 2008
    ..Additionally, they will provide critical information on pivotal properties of gene expression that might lead to possible therapeutic applications. ..
  24. Role of dendritic cells in resistance to Toxoplasma.
    Christopher A Hunter; Fiscal Year: 2010
    ..gondii and their contribution to the development of innate and adaptive mechanisms of resistance to this pathogen. ..
  25. New Approaches to Schistosome vaccine antigen discovery
    Christopher King; Fiscal Year: 2008
    ..An effective vaccine could transform control programs for schistosomiasis by reducing the costs of repeated treatment, and the risk of developing drug resistance. ..
  26. BIOGENESIS OF HYDROGENOSOMES OF A TRICHOMONAD PARASITE
    Patricia Johnson; Fiscal Year: 2003
    ..This detailed analysis will provide valuable insights into the origin and biogenesis of hydrogenosomes and information of potential chemotherapeutic importance. ..
  27. Confocal Microscope for Microbiology
    L Sibley; Fiscal Year: 2002
    ..This instrument will greatly strengthen the research programs of these highly productive groups by applying high-resolution confocal microscopy to the study of human pathogens...
  28. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..abstract_text> ..
  29. REGULATION OF THE ERYTHROPOIETIN GENE
    H Bunn; Fiscal Year: 2003
    ..These studies should provide unique and highly relevant information about common mechanisms of oxygen sensing, signal transduction and gene regulation that enable organisms to adapt to hypoxia. ..
  30. Role of NFKB in resistance to Toxoplasma gondii
    Christopher Hunter; Fiscal Year: 2005
    ....
  31. REGULATION OF DEVELOPMENT BY PHOSPHORELAY SIGNALING
    CHARLES SINGLETON; Fiscal Year: 2002
    ..Finally genetic screens for suppressers or synthetic phenotypes will identify new and perhaps novel components of the regulatory pathway, including upstream inputs, phosphorelay regulators, and downstream effectors. ..
  32. Mucosal Immunity to Toxoplasma gondii
    L Sibley; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. GENE DISCOVERY IN TOXOPLASMA GONDII
    L Sibley; Fiscal Year: 2003
    ..In combination with the genetic tools available in T. gondii, this will greatly accelerate investigations into the complex developmental biology of apicomplexan parasites. ..
  34. A new family of secreted adhesive proteins in Plasmodium
    THOMAS TEMPLETON; Fiscal Year: 2008
    ....
  35. MOLECULAR ANALYSIS OF THE GLYCOSOME.
    Marilyn Parsons; Fiscal Year: 2004
    ..Their studies are aimed at understanding glycosomal biogenesis and protein input and the relationship of these processes and the molecules involved to peroxisome biogenesis in the human host. ..
  36. Forward Genetics in Tetrahymena: Cloning by Complementation
    ROBERT COYNE; Fiscal Year: 2008
    ..Numerous other basic studies with far-reaching relevance to human health would be facilitated by the availability of the proposed freely available resource. [unreadable] [unreadable] [unreadable] [unreadable]..
  37. Enzyme Targets-Sterol Synthesis-Opportunistic Pathogens
    WILLIAM NES; Fiscal Year: 2004
    ..The results from these studies will facilitate the design of therapeutic strategies aimed to provide species-specific discrimination of inhibition in the ergosterol biosynthetic pathway. ..
  38. OXYGEN SENSING AND SIGNAL TRANSDUCTION
    H Bunn; Fiscal Year: 2003
    ..abstract_text> ..
  39. Role of Macrophage Arginase in Anti-Bacterial Immunity
    Peter Murray; Fiscal Year: 2009
    ..The outcomes of the proposed studies will reveal new elements of Arg I function and provide rationale for approaching Arg I as a target in inflammatory diseases. ..
  40. Developing a Measure of Brain Insults In Kenyan Children
    Penny Holding; Fiscal Year: 2004
    ..The longer-term objective is to provide scientists in East Africa with a rigorously developed methodology for the investigation of the sequelae of brain disorders of pre-natal and peri-natal origin. ..
  41. PROTEIN PHOSPHORYLATION IN TRYPANOSOMES
    Marilyn Parsons; Fiscal Year: 2010
    ..Together these studies will signficantly expand our knowledge of the network of signaling interactions in trypanosomes, with the goal of identifying new drug and vaccine targets. ..
  42. THE PHYSIOLOGY OF DRUG RESISTANT MALARIA
    PAUL ROEPE; Fiscal Year: 2009
    ..Knowledge gained during this research will significantly expand our understanding of malarial parasite physiology and antimalarial drug resistance. ..
  43. A SARS-CoV Spike Protein Vaccine
    B Sim; Fiscal Year: 2005
    ..abstract_text> ..
  44. A Tetravalent Dengue Recombinanat Protein Vaccine
    B Sim; Fiscal Year: 2005
    ..abstract_text> ..
  45. Adherence of malaria-infected red cells
    Alan Cowman; Fiscal Year: 2009
    ..These studies will contribute to and increased understanding of the pathophysiology of falciparum malaria. ..
  46. Trichomonas vaginalis: Molecular Analysis of Adherence
    JOHN ALDERETE; Fiscal Year: 2007
    ..abstract_text> ..
  47. Role of SOCS proteins in host-pathogen responses
    Peter Murray; Fiscal Year: 2003
    ..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
  48. Calcium ATPases in Apicomplexan Parasites as Potential D
    L Sibley; Fiscal Year: 2006
    ..Knowledge gained through these studies may improve the ability to pharmacologically inhibit key calcium regulatory enzymes and hence block motility and invasion by this important group of parasites. ..
  49. Toxoplasma Gondii Regulation of Host Gene Expression
    Ira Blader; Fiscal Year: 2004
    ..abstract_text> ..
  50. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  51. A NOVEL MICROTUBULE-ASSOCIATED PROTEIN IN TRYPANOSOMES
    KENT HILL; Fiscal Year: 2002
    ....
  52. Biochemical and Functional Analysis of Trypanin
    KENT HILL; Fiscal Year: 2007
    ..Therefore, in addition to addressing fundamental questions in cell biology, this research directly impacts efforts to understand and treat infectious diseases and genetic diseases in humans. ..
  53. Immunoglobulin Allotypes in Hepatitis C Virus Infection
    JANARDAN PANDEY; Fiscal Year: 2008
    ..Results of this investigation will advance our understanding of the role of host genetic factors in clearance and persistence of hepatitis C virus infection. ..
  54. Molecular epidemiology of drug resistant malaria
    MIRIAM LAUFER; Fiscal Year: 2008
    ..abstract_text> ..
  55. CORE GRANT FOR VISION RESEARCH
    Noorjahan Panjwani; Fiscal Year: 2005
    ..abstract_text> ..
  56. Antigenic Variation and Drug Resistance In P. falciparum
    Qin Cheng; Fiscal Year: 2006
    ..The project has the potential to benefit the health of a substantial proportion of the world's population. ..
  57. The Role of Selectin-Mediated Recognition in Glaucoma
    Noorjahan Panjwani; Fiscal Year: 2006
    ..The proposed studies will determine whether the selectin-based carbohydrate recognition system plays a role in the pathogenic mechanisms of aqueous outflow resistance in glaucoma. ..
  58. Topoisomerases: Target for Antitrypanosomal Therapy
    Theresa Shapiro; Fiscal Year: 2006
    ..Compounds that appear most promising will be evaluated in mice. These studies take a multi-faceted, rational, and tangible approach to the development of much-needed new anti-trypanosomal chemotherapy. ..
  59. High Throughput Assay for Screening Compounds(RMI)
    James McKerrow; Fiscal Year: 2005
    ..Computational and informatics capability is in place to acquire, store and cross-reference this data, and provide access to the scientific community through an open-source website. ..
  60. Genetics & Population Structure of Plasmodium falciparum
    Stephen Rich; Fiscal Year: 2007
    ..This work will increase our understanding of the genomic evolution of this parasite will yield valuable information for evaluating appropriate strategies for intervening in disease transmission. ..
  61. BORRELIA EVOLUTION AND POPULATION STRUCTURE
    Stephen Rich; Fiscal Year: 2004
    ..abstract_text> ..
  62. Trypanosomatid Mitochondrial DNA Polymerases
    Michele Klingbeil; Fiscal Year: 2008
    ..The T. brucei pol I-like protein family also offers the unique opportunity to uncover insights into the evolutionary strategies used to produce a replicative polymerase. ..
  63. SWITCHING IN THE ORAL COMMENSAL CANDIDA GLABRATA
    David Soll; Fiscal Year: 2006
    ..abstract_text> ..
  64. Switching and Candida Pathogenesis-A Molecular Analysis
    David Soll; Fiscal Year: 2005
    ..The first three aims have been formulated so that they provide several independent starting points for a reverse genetic approach for elucidating switch loci and the switching mechanism. ..
  65. Host Protein Degradation by Schistosome Parasites
    James McKerrow; Fiscal Year: 2007
    ..abstract_text> ..