protozoan proteins

Summary

Summary: Proteins found in any species of protozoan.

Top Publications

  1. pmc PlasmoDB: a functional genomic database for malaria parasites
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 37:D539-43. 2009
  2. pmc TriTrypDB: a functional genomic resource for the Trypanosomatidae
    Martin Aslett
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 38:D457-62. 2010
  3. doi CD8+ T effector memory cells protect against liver-stage malaria
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:1347-57. 2011
  4. pmc The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis
    Freya J I Fowkes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Med 7:e1000218. 2010
  5. pmc Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    G J Pazour
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biol 151:709-18. 2000
  6. pmc Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei
    T Nicolai Siegel
    Laboratory of Molecular Parasitology, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 23:1063-76. 2009
  7. pmc Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family
    Joel H Janes
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 7:e1002032. 2011
  8. pmc False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene
    Ousmane A Koita
    Mali Tulane Tropical Medicine Research Center, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 86:194-8. 2012
  9. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005
  10. pmc Proteomic analysis of a eukaryotic cilium
    Gregory J Pazour
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 170:103-13. 2005

Research Grants

Detail Information

Publications333 found, 100 shown here

  1. pmc PlasmoDB: a functional genomic database for malaria parasites
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 37:D539-43. 2009
    ..Various results can then be combined with each other on the query history page. Search results can be downloaded with associated functional data and registered users can store their query history for future retrieval or analysis...
  2. pmc TriTrypDB: a functional genomic resource for the Trypanosomatidae
    Martin Aslett
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nucleic Acids Res 38:D457-62. 2010
    ....
  3. doi CD8+ T effector memory cells protect against liver-stage malaria
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:1347-57. 2011
    ..Thus, we identify persistent CD8 T(EM) populations as essential for vaccine-induced pre-erythrocytic protection against malaria, a finding that has important implications for vaccine design...
  4. pmc The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis
    Freya J I Fowkes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Med 7:e1000218. 2010
    ..However, published evidence of the protective effect of these antibodies is conflicting...
  5. pmc Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    G J Pazour
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biol 151:709-18. 2000
    ..This indicates that IFT is important for primary cilia assembly in mammals. It is likely that primary cilia have an important function in the kidney and that defects in their assembly can lead to polycystic kidney disease...
  6. pmc Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei
    T Nicolai Siegel
    Laboratory of Molecular Parasitology, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 23:1063-76. 2009
    ....
  7. pmc Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family
    Joel H Janes
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 7:e1002032. 2011
    ....
  8. pmc False-negative rapid diagnostic tests for malaria and deletion of the histidine-rich repeat region of the hrp2 gene
    Ousmane A Koita
    Mali Tulane Tropical Medicine Research Center, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 86:194-8. 2012
    ..These findings suggest that the use of HRP2-based RDTs should be reconsidered...
  9. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005
    ..Thus, serological tools allow us to detect variations in malaria transmission over time. Such tools will be invaluable for monitoring trends in malaria endemicity and the effectiveness of malaria control programs...
  10. pmc Proteomic analysis of a eukaryotic cilium
    Gregory J Pazour
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 170:103-13. 2005
    ..The flagellum also contains many proteins that are conserved in humans but have not been previously characterized in any organism. The results indicate that flagella are far more complex than previously estimated...
  11. pmc Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern
    Mario Recker
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 7:e1001306. 2011
    ..falciparum malaria as a balanced process of parasite-intrinsic switching and immune-mediated selection...
  12. pmc Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom
    Infect Immun 78:145-53. 2010
    ....
  13. doi Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum
    Wai Hong Tham
    Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Vic, Australia
    Trends Parasitol 28:23-30. 2012
    ....
  14. pmc EuPathDB: a portal to eukaryotic pathogen databases
    Cristina Aurrecoechea
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 38:D415-9. 2010
    ..Search results are dynamically displayed as the strategy is constructed or modified, and can be downloaded, saved, revised, or shared with other database users...
  15. pmc Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites
    Shailja Singh
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS Pathog 6:e1000746. 2010
    ..Signaling pathway components involved in apical organelle discharge may serve as novel targets for drug development since inhibition of microneme and rhoptry secretion can block invasion and limit blood-stage parasite growth...
  16. pmc Plasmodium falciparum var gene expression is modified by host immunity
    George M Warimwe
    Kenya Medical Research Institute Wellcome Trust Research Programme, 80108 Kilifi, Kenya
    Proc Natl Acad Sci U S A 106:21801-6. 2009
    ..This may help the parasite to adapt effectively to the development of host antibodies through modification of the host-parasite relationship...
  17. doi Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum
    Lev Solyakov
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, UK
    Nat Commun 2:565. 2011
    ..These studies not only reveal processes that are regulated by protein phosphorylation, but also define potential anti-malarial drug targets within the parasite kinome...
  18. pmc The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission
    Rita Tewari
    Institute of Genetics, QMC, University of Nottingham, Nottingham NG7 2UH, UK
    Cell Host Microbe 8:377-87. 2010
    ....
  19. pmc Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:13275-80. 2011
    ..Collectively, these results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON2 as a potential vaccine candidate...
  20. pmc Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites
    Dave Richard
    Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia
    J Biol Chem 285:14815-22. 2010
    ..We propose that the formation of the AMA1-RON complex is essential for secretion of the rhoptry contents, which then allows the establishment of parasite infection within the parasitophorous vacuole...
  21. pmc Draft genome sequencing of giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species?
    Oscar Franzén
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    PLoS Pathog 5:e1000560. 2009
    ..01% in WB). The genomic differences between WB and GS may explain some of the observed biological and clinical differences between the two isolates, and it suggests that assemblage A and B Giardia can be two different species...
  22. pmc Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes
    Karla Pérez-Toledo
    Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional IPN, Apartado Postal 14 740, 07360, Mexico D F, Mexico
    Nucleic Acids Res 37:2596-606. 2009
    ..This is the first report implicating an HP1 protein in the control of antigenic variation of a protozoan parasite...
  23. ncbi Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method
    Christopher J Tonkin
    Plant Cell Biology Research Centre, School of Botany, The University of Melbourne, Parkville, VIC 3010, Australia
    Mol Biochem Parasitol 137:13-21. 2004
    ..falciparum proteins...
  24. doi An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages
    Judith Maxwell Silverman
    Department of Medicine, Division of Infectious Diseases, University of British Columbia, Faculties of Medicine and Science, 2733 Heather St, Vancouver, BC V5Z 3J5, Canada
    J Cell Sci 123:842-52. 2010
    ..Moreover, we describe a mechanism for the direct delivery of Leishmania molecules into macrophages. These findings suggest that, like mammalian exosomes, Leishmania exosomes function in long-range communication and immune modulation...
  25. ncbi The genome of the African trypanosome Trypanosoma brucei
    Matthew Berriman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Science 309:416-22. 2005
    ..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
  26. pmc Spiroindolones, a potent compound class for the treatment of malaria
    Matthias Rottmann
    Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH 4002 Basel, Switzerland
    Science 329:1175-80. 2010
    ..The optimized spiroindolone NITD609 shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model...
  27. ncbi In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
    Christin Sisowath
    Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Infect Dis 191:1014-7. 2005
    ..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
  28. doi Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines
    Simon J Draper
    Jenner Institute, University of Oxford, Oxford, OX3 7DQ, United Kingdom
    J Immunol 185:7583-95. 2010
    ..These data encourage the further clinical development and coadministration of protein and viral vector vaccine platforms in an attempt to induce broad cellular and humoral immune responses against blood-stage malaria Ags in humans...
  29. pmc Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum
    Christopher J Tonkin
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    PLoS Biol 7:e84. 2009
    ..This work highlights the pivotal but distinct role for both PfSir2 paralogues in epigenetic silencing of P. falciparum virulence genes and the control of pathogenicity of malaria infection...
  30. pmc Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites
    Sash Lopaticki
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Infect Immun 79:1107-17. 2011
    ..This validates the use of a combination of these ligands as a potential vaccine that would have broad activity against P. falciparum...
  31. pmc A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes
    Jeffrey D Dvorin
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 328:910-2. 2010
    ..The arrest was downstream of cyclic guanosine monophosphate-dependent protein kinase (PfPKG) function and independent of protease processing. Thus, PfCDPK5 plays an essential role during the blood stage of malaria replication...
  32. pmc Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara
    Daniel P Webster
    Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK
    Proc Natl Acad Sci U S A 102:4836-41. 2005
    ....
  33. pmc var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2
    Letusa Albrecht
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Malar J 10:17. 2011
    ..Binding of the pRBC is mediated by Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a large multi-variant molecule encoded by a family of ≈60 var genes...
  34. pmc Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169
    Susanne Kramer
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    J Cell Sci 121:3002-14. 2008
    ....
  35. pmc Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80
    My Hang Huynh
    Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Eukaryot Cell 8:530-9. 2009
    ..LIC constructs reduces both the time and cost required to determine localization of a new gene of interest. This should allow the opportunity for performing larger-scale studies of novel T. gondii genes...
  36. pmc Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex
    Thomas Nebl
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    PLoS Pathog 7:e1002222. 2011
    ..This suggests that invasion motor activity could be regulated not only by phosphorylation but also by the direct binding of calcium ions to this new component...
  37. doi Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial
    Kwaku Poku Asante
    Kintampo Health Research Centre, Kintampo, Ghana
    Lancet Infect Dis 11:741-9. 2011
    ..8 month follow-up data have been reported for safety and immunogenicity of RTS,S/AS01(E) when integrated into the EPI. We report extended follow-up to 19 months, including efficacy results...
  38. pmc Genetic diversity among Plasmodium falciparum field isolates in Pakistan measured with PCR genotyping of the merozoite surface protein 1 and 2
    Najia K Ghanchi
    Department of Pathology and Microbiology, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Malar J 9:1. 2010
    ..This study aimed to establish molecular characterization of P. falciparum field isolates in Pakistan measured with two highly polymorphic genetic markers, i.e. the merozoite surface protein 1 (msp-1)and 2 (msp-2)...
  39. doi Molecular analysis of pfatp6 and pfmdr1 polymorphisms and their association with in vitro sensitivity in Plasmodium falciparum isolates from the Thai-Myanmar border
    Papichaya Phompradit
    Thailand Center of Excellence on Drug Discovery and Development, Thammasat University, Rangsit Campus, Patumthani 12121, Thailand
    Acta Trop 120:130-5. 2011
    ..No association between mutation or amplification of pfatp6 gene and in vitro susceptibility of P. falciparum isolates was found...
  40. pmc Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component
    Cindy Tamminga
    U S Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 6:e25868. 2011
    ..As adenovirus vaccine vectors induce both these responses in humans, a Phase 1/2a clinical trial was conducted to evaluate the efficacy of an adenovirus serotype 5-vectored malaria vaccine against sporozoite challenge...
  41. pmc Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance
    Maria Isabel Veiga
    Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e20212. 2011
    ..Our work unveils new candidate markers of P. falciparum multidrug resistance in vitro, while contributing to the understanding of subjacent genetic complexity, essential for future evidence-based drug policy decisions...
  42. doi Apical membrane antigen 1: a malaria vaccine candidate in review
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    Trends Parasitol 24:74-84. 2008
    ..The current understanding of AMA1 will be presented, particularly in relation to the vaccine potential of AMA1 and the approaches being taken towards clinical development...
  43. ncbi From the circumsporozoite protein to the RTS, S/AS candidate vaccine
    Joe Cohen
    GlaxoSmithKline Biologicals, Belgium
    Hum Vaccin 6:90-6. 2010
    ....
  44. doi Spread and evolution of Plasmodium falciparum drug resistance
    Toshihiro Mita
    Department of International Affairs and Tropical Medicine, Tokyo Women s Medical University, School of Medicine, 9 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Parasitol Int 58:201-9. 2009
    ....
  45. pmc Radial spoke proteins of Chlamydomonas flagella
    Pinfen Yang
    Department of Biological Sciences, Marquette University, Milwaukee, WI 53233, USA
    J Cell Sci 119:1165-74. 2006
    ..The human genes encoding these proteins are candidates for causing primary ciliary dyskinesia, a severe inherited disease involving missing or defective axonemal structures, including the radial spokes...
  46. doi Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia
    Jack S Richards
    Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, Australia
    Clin Infect Dis 51:e50-60. 2010
    ..Erythrocyte-binding antigens (EBAs) are important erythrocyte invasion ligands used by merozoites and may be targets of protective immunity, but there are limited data examining their potential importance...
  47. doi Functional dissection of the apicomplexan glideosome molecular architecture
    Karine Frénal
    Department of Microbiology and Molecular Medicine, Centre Medical Universitaire, University of Geneva, CH 1211 Geneva 4, Switzerland
    Cell Host Microbe 8:343-57. 2010
    ....
  48. pmc A multifunctional serine protease primes the malaria parasite for red blood cell invasion
    Konstantinos Koussis
    Division of Parasitology, National Institute for Medical Research, London, UK
    EMBO J 28:725-35. 2009
    ..We propose that PfSUB1 is a multifunctional processing protease with an essential role in both egress of the malaria merozoite and remodelling of its surface in preparation for erythrocyte invasion...
  49. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    ..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
  50. ncbi Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes
    Sharon Yeoh
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Cell 131:1072-83. 2007
    ..Our findings reveal the presence in the malarial parasitophorous vacuole of a regulated, PfSUB1-mediated proteolytic processing event required for release of viable parasites from the host erythrocyte...
  51. ncbi Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex
    Ben J Mans
    National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Cycle 3:1612-37. 2004
    ..A primitive NPC with approximately 20 proteins and a Src1p-Man1-like membrane protein with a DNA-tethering HEH domain are inferred to have been integral perinuclear components in the las common ancestor of modern eukaryotes...
  52. pmc A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology
    Christian Flueck
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, University of Basel, Basel, Switzerland
    PLoS Pathog 6:e1000784. 2010
    ..These findings are highly relevant for our understanding of chromosome end biology and variegated expression in P. falciparum and other eukaryotes, and for the future analysis of the role of ApiAP2-DNA interactions in parasite biology...
  53. pmc Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery
    Jan Mani
    Institute of Cell Biology, University of Bern, Bern, Switzerland
    PLoS ONE 6:e22463. 2011
    ..Our results are also consistent with stage-specific regulation of translation in trypanosomes, but most likely in the context of initiation...
  54. pmc Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
    Andrew P Jackson
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 109:3416-21. 2012
    ....
  55. pmc Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1
    Louise Joergensen
    Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    PLoS Pathog 6:e1001083. 2010
    ..These new results on PfEMP1 antigen expression indicate that a re-evaluation of the molecular mechanisms involved in P. falciparum adhesion and of the accepted paradigm of absolutely mutually exclusive var gene transcription is required...
  56. pmc Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults
    Martha Sedegah
    U S Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 6:e24586. 2011
    ....
  57. pmc Metacaspases
    L Tsiatsiani
    Department of Plant Systems Biology, VIB, Ghent, Belgium
    Cell Death Differ 18:1279-88. 2011
    ..To prevent further misapplication of caspase-specific molecular probes for measuring and inhibiting metacaspase activity, we provide a list of probes suitable for metacaspases...
  58. ncbi Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD)
    Isabel L Mauricio
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Parasitol 36:757-69. 2006
    ..Furthermore, it can be used to detect recombination indirectly and for population genetics studies...
  59. doi Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes
    Daniel E Goldberg
    Howard Hughes Medical Institute, Washington University School of Medicine, Department of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Microbiol 8:617-21. 2010
    ..In addition, this export pathway provides potentially useful targets for the development of inhibitors to interfere with functions that are vital for the virulence and survival programmes of the parasite...
  60. pmc Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs
    Bécaye Fall
    1Laboratoire d étude de la chimiosensibilité du paludisme, Fédération deslaboratoires, Hôpital Principal de Dakar, Dakar, Senegal
    Malar J 10:310. 2011
    ..To examine whether parasite susceptibility has been affected by the widespread use of ACT, the ex vivo susceptibility of local isolates was assessed at the military hospital of Dakar...
  61. pmc Intraflagellar transport (IFT) protein IFT25 is a phosphoprotein component of IFT complex B and physically interacts with IFT27 in Chlamydomonas
    Zhaohui Wang
    Department of Biology, Texas A and M University, College Station, Texas, USA
    PLoS ONE 4:e5384. 2009
    ..The function of IFT proteins in flagellar assembly has been extensively investigated. However, much less is known about the molecular mechanism of how IFT is regulated...
  62. doi Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda
    Heidi Hopkins
    University of California, San Francisco, San Francisco, California, USA
    J Infect Dis 197:510-8. 2008
    ..In Africa, fever is often treated presumptively as malaria, resulting in misdiagnosis and the overuse of antimalarial drugs. Rapid diagnostic tests (RDTs) for malaria may allow improved fever management...
  63. doi Phosphatidylinositol-phosphates mediate cytoskeletal reorganization during phagocytosis via a unique modular protein consisting of RhoGEF/DH and FYVE domains in the parasitic protozoon Entamoeba histolytica
    Kumiko Nakada-Tsukui
    Department of Parasitology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    Cell Microbiol 11:1471-91. 2009
    ..Altogether, we demonstrated that PtdIns(3)P, PtdIns(4)P and EhFP4 coordinately regulate phagocytosis and phagosome maturation in this parasitic eukaryote...
  64. pmc The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites
    Mauld Lamarque
    UMR 5235 CNRS, Université de Montpellier 2, Montpellier, France
    PLoS Pathog 7:e1001276. 2011
    ..gondii and P. falciparum entry into their host cells. This work provides the first evidence that AMA1 uses the rhoptry neck protein RON2 as a receptor to promote invasion by Apicomplexa parasites...
  65. pmc Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial
    Ally Olotu
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Lancet Infect Dis 11:102-9. 2011
    ..We recently showed efficacy against clinical falciparum malaria in 5-17 month old children, during an average of 8 months follow-up. We aimed to assess the efficacy of RTS,S/AS01E during 15 months of follow-up...
  66. pmc The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex
    Jessica S Tyler
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 7:e1001282. 2011
    ..Hence, the entire C-terminal region of TgRON2 forms the crucial bridge between TgAMA1 and the rest of the MJ complex but this association is not required for rhoptry protein injection...
  67. pmc Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A
    Michele D Spring
    United States Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 4:e5254. 2009
    ....
  68. pmc Plasmodium vivax: who cares?
    Mary R Galinski
    Emory Vaccine Center and Yerkes National Primate Research Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA
    Malar J 7:S9. 2008
    ....
  69. pmc The origin of malignant malaria
    Stephen M Rich
    Laboratory of Medical Zoology, Division of Entomology PSIS, University of Massachusetts, Amherst, MA 01003, USA
    Proc Natl Acad Sci U S A 106:14902-7. 2009
    ..reichenowi. More recently, mutations in the dominant invasion receptor EBA 175 in the P. falciparum lineage provided the parasite with preference for the overabundant Neu5Ac precursor, accounting for its extreme human pathogenicity...
  70. pmc Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children
    Gerald K K Cham
    Centre for Medical Parasitology, University of Copenhagen, Copenhagen K, Denmark
    Infect Immun 78:4653-9. 2010
    ..The results imply that anti-PfEMP1 antibodies effectively structure PfEMP1 expression and play a major role in limiting parasite multiplication in the blood...
  71. pmc High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model
    Sheetij Dutta
    Department of Epitope Mapping, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 4:e8138. 2009
    ..High titers of cross-strain inhibitory antibodies against AMA1 are therefore critical to confer solid protection, and the Aotus model can be used to down-select future AMA1 formulations, prior to advanced human trials...
  72. pmc Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses
    Lucia Peixoto
    Department of Biology and Penn Genome Frontiers Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Host Microbe 8:208-18. 2010
    ..These results highlight the value of integrative genomic approaches in prioritizing candidates for functional validation...
  73. pmc Assessment of the prozone effect in malaria rapid diagnostic tests
    Philippe Gillet
    Department of Clinical Sciences, Institute of Tropical Medicine ITM, Nationalestraat 155, B 2000 Antwerp, Belgium
    Malar J 8:271. 2009
    ..In this study, a panel of malaria RDTs was challenged with clinical samples with P. falciparum hyperparasitaemia (> 5% infected red blood cells)...
  74. pmc Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age
    Philip Bejon
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    N Engl J Med 359:2521-32. 2008
    ..We evaluated the efficacy of RTS,S given with a more immunogenic adjuvant system (AS01E) in children 5 to 17 months of age, a target population for vaccine licensure...
  75. ncbi An in vitro system for developmental and genetic studies of Leishmania donovani phosphoglycans
    Sophie Goyard
    Department of Molecular Microbiology, Washington University Medical School, Campus Box 8230, 660 S Euclid Ave, St Louis, MO 63110, USA
    Mol Biochem Parasitol 130:31-42. 2003
    ..These and other data suggest that LdB axenic amastigotes will be generally useful as a differentiation model in studies of gene expression, virulence, glycoconjugate function and drug susceptibility in L. donovani...
  76. pmc Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1
    D C Ghislaine Mayer
    Department of Biology, Virginia Commonwealth University, 1000 West Cary Street, Room 126, Richmond, VA 23284 2012, USA
    Proc Natl Acad Sci U S A 106:5348-52. 2009
    ....
  77. pmc Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 5:e15391. 2010
    ..Our data confirms the feasibility and potential of multi-allele PfAMA1 formulations, and highlights the need for adjuvants with improved antibody potentiation properties for AMA1-based vaccines...
  78. pmc A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii
    Brooke R Anderson-White
    Department of Biology, Boston College, Chestnut Hill, MA, USA
    Cell Microbiol 13:18-31. 2011
    ..Furthermore we identified IMC15 as an early marker of budding and, lastly, the dynamic patterns observed throughout cytokinesis provide a timeline for daughter parasite development and division...
  79. pmc The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands
    Min Zhang
    Michael Heidelberger Division, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 207:1465-74. 2010
    ..Thus, to complete their life cycle, Plasmodium sporozoites exploit the mechanism that regulates stress responses in eukaryotic cells...
  80. doi Analysis of Plasmodium falciparum var genes expressed in children from Papua New Guinea
    Nicole Falk
    Swiss Tropical Institute, Basel, Switzerland
    J Infect Dis 200:347-56. 2009
    ..We conducted a case-control study in Papua New Guinea and analyzed transcribed var genes in naturally infected children...
  81. pmc A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
    Infect Immun 76:2660-70. 2008
    ..This suggests that vaccines based upon the DiCo mix approach provide a broader functional immunity than immunization with a single allele...
  82. pmc Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda
    Daniel J Kyabayinze
    Malaria Consortium Africa, Plot 2, Sturrock Road, P O Box 8045, Kampala, Uganda
    Malar J 7:221. 2008
    ..An assessment of the accuracy of Malaria Pf immuno-chromatographic test (ICT) and description of persistent antigenicity of HRP2 RDTs was undertaken in a hyperendemic area of Uganda...
  83. ncbi The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
    Najib M El-Sayed
    Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
    Science 309:409-15. 2005
    ....
  84. doi The development of the RTS,S malaria vaccine candidate: challenges and lessons
    W R Ballou
    Infectious Diseases Development, Global Health Division, Bill and Melinda Gates Foundation, PO Box 23350, Seattle, WA, USA
    Parasite Immunol 31:492-500. 2009
    ....
  85. ncbi Urban malaria in Dakar, Senegal: chemosusceptibility and genetic diversity of Plasmodium falciparum isolates
    Maud Henry
    Unité de Recherche en Biologie et Epidémiologie Parasitaires, Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France
    Am J Trop Med Hyg 75:146-51. 2006
    ..Areas with urban malaria should use vector control measures and efficient chemoprophylaxis for non-immune populations...
  86. pmc Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Eukaryot Cell 8:520-9. 2009
    ....
  87. ncbi Invasion of red blood cells by malaria parasites
    Alan F Cowman
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Cell 124:755-66. 2006
    ..While some Apicomplexa can invade many different host cells, the disease-associated blood-stage form of the malaria parasite is restricted to erythrocytes...
  88. doi Ubiquitylation is required for degradation of transmembrane surface proteins in trypanosomes
    Wei Lian Chung
    Department of Pathology, University of Cambridge, Cambridge, UK
    Traffic 9:1681-97. 2008
    ..Hence, ubiquitylation is an evolutionarily conserved mechanism for internalization of surface proteins, but aspects of the machinery differ substantially between the major eukaryotic lineages...
  89. ncbi A receptor for the malarial parasite Plasmodium vivax: the erythrocyte chemokine receptor
    R Horuk
    Genentech, Inc, South San Francisco, CA 94080
    Science 261:1182-4. 1993
    ..Third, both MGSA and IL-8 blocked the binding of the parasite ligand and the invasion of human erythrocytes by P. knowlesi, suggesting the possibility of receptor blockade for anti-malarial therapy...
  90. pmc An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype
    Inès Vigan-Womas
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, CNRS URA 2581, 25 rue du Dr Roux, F 75724 Paris, France
    Infect Immun 76:5565-80. 2008
    ....
  91. doi Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains
    Gerald K K Cham
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    J Immunol 183:3356-63. 2009
    ..The identification of PfEMP1 domains expressed by parasites causing disease in infants and young children is important for development of vaccines protecting against severe malaria...
  92. pmc A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3
    Masahiro Yamamoto
    Department of Microbiology and Immunology, Graduate School of Medicine, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 206:2747-60. 2009
    ..These results formally establish an essential and direct requirement of ROP16 in parasite-induced Stat3 activation and the significance of a single amino acid replacement in the function of type II ROP16...
  93. pmc The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness
    Isabelle R E Nett
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Mol Cell Proteomics 8:1527-38. 2009
    ....
  94. ncbi Comparison of PCR-RFLP and Genescan-based genotyping for analyzing infection dynamics of Plasmodium falciparum
    Nicole Falk
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 74:944-50. 2006
    ..This reflects the good performance of GeneScan-based genotyping for studies of parasite infection dynamics...
  95. ncbi Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity
    Morten A Nielsen
    Center for Medical Parasitology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    J Immunol 168:3444-50. 2002
    ..This opens the possibility of developing morbidity-reducing vaccines targeting a limited subset of common and particularly virulent VSA...
  96. pmc Comparison of Plasmodium falciparum allelic frequency distribution in different endemic settings by high-resolution genotyping
    Sonja Schoepflin
    Swiss Tropical Institute, Basel, Switzerland
    Malar J 8:250. 2009
    ..These previous reports relied on low resolution genotyping techniques...
  97. pmc Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 4:e8110. 2009
    ..This explains the broadened cross inhibition of diverse malaria parasites, and suggests multi-allele approaches warrant further clinical investigation...
  98. pmc A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
    Shane R Wilkinson
    School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, United Kingdom
    Proc Natl Acad Sci U S A 105:5022-7. 2008
    ..This potential for drug resistance by a simple mechanism has important implications, because nifurtimox is currently undergoing phase III clinical trials against African trypanosomiasis...
  99. pmc Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development
    Gunnar R Mair
    Leiden Malaria Research Group, Department of Parasitology, Centre for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Pathog 6:e1000767. 2010
    ..Therefore, translational repression may offer avenues as a target for the generation of transmission blocking strategies and contribute to limiting the spread of malaria...
  100. pmc Toxoplasma gondii targets a protein phosphatase 2C to the nuclei of infected host cells
    Luke A Gilbert
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095 1489, USA
    Eukaryot Cell 6:73-83. 2007
    ..The delivery of parasite effector proteins via the rhoptries provides a novel mechanism for Toxoplasma to directly access the command center of its host cell during infection by the parasite...
  101. pmc Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine
    Juliana Martha Sá
    Laboratory of Malaria and Vector Research and Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:18883-9. 2009
    ..Increasing use of AQ in Africa poses the threat of a selective sweep of highly AQ-resistant, CQ-resistant parasites with pfcrt and pfmdr1 mutations that are as advantaged and persistent as in South America...

Research Grants209 found, 100 shown here

  1. Development of a P. vivax immunization and sporozoite challenge model for human
    Socrates Herrera; Fiscal Year: 2009
    ..5 billion exposed humans. ..
  2. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2005
    ..abstract_text> ..
  3. Development of a P. vivax immunization and sporozoite challenge model for human
    Socrates Herrera; Fiscal Year: 2010
    ..5 billion exposed humans. ..
  4. The Plasmodium 2TM and PHIST protein families
    Thomas J Templeton; Fiscal Year: 2010
    ..The expression, cellular localization, and phenotype following targeted gene disruption will be studied for select PHIST domain proteins toward an understanding of their function within the erythrocyte cytoplasm. ..
  5. CYTOSOLIC GLYCOSYLATION
    Christopher West; Fiscal Year: 2001
    ....
  6. Modular design of central metabolism in methylotrophs
    Gregory Crowther; Fiscal Year: 2006
    ..abstract_text> ..
  7. Cryptosporidium parvum Histone Deacetylases
    STANLEY RIDER; Fiscal Year: 2007
    ..There are currently no highly effective treatments for Cryptosporidium parvum. This research is a beginning step toward identifying novel methods to control this parasite. ..
  8. Software tools for analysis and visulaization of protein structure
    Ethan Merritt; Fiscal Year: 2007
    ..The algorithms and computation tools developed as part of this work will be distributed freely, and we will provide web-based state of the art analysis of structures submitted by external researchers. ..
  9. Cytosolic Proline Hydroxylation and Glycosylation
    Christopher West; Fiscal Year: 2007
    ....
  10. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher M West; Fiscal Year: 2010
    ..gondii, which is widely disseminated latently in the human population and for which, if it is re-activated, pharmacological therapies are extremely limited. ..
  11. Protein trafficking to lysosome-like vacuoles in Giardai
    Maria C Touz; Fiscal Year: 2010
    ..Besides, enlighten the endosomal-lysosomal pathway in Giardia may contribute to the design of therapeutic agents against this important human pathogen. ..
  12. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher M West; Fiscal Year: 2011
    ..gondii, which is widely disseminated latently in the human population and for which, if it is re-activated, pharmacological therapies are extremely limited. ..
  13. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher West; Fiscal Year: 2009
    ..gondii, which is widely disseminated latently in the human population and for which, if it is re-activated, pharmacological therapies are extremely limited. ..
  14. Cytosolic Proline Hydroxylation and Glycosylation
    Christopher West; Fiscal Year: 2009
    ..drug discovery initiatives for animal P4H enzymes might find unanticipated applications in control of protozoan infectious disease, as inhibitors might compromise pathogen adaptation to hypoxic conditions or stress! ..
  15. RNA Uridylytransferases of Trypanosomes
    Ruslan Aphasizhev; Fiscal Year: 2009
    ..Sequences of the newly identified UTP-specific transferases will be used to establish characteristic protein motifs for this family of enzymes. ..
  16. Protein trafficking to lysosome-like vacuoles in Giardai
    MARIA TOUZ; Fiscal Year: 2007
    ..Besides, enlighten the endosomal-lysosomal pathway in Giardia may contribute to the design of therapeutic agents against this important human pathogen. ..
  17. CYTOSOLIC GLYCOSYLATION
    Christopher West; Fiscal Year: 2005
    ..In addition, the enzyme sequences are expected to be useful for the identification of homologous genes, in the cytoplasm or Golgi, of other 'lower' organisms as their genome sequences are completed. ..
  18. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher M West; Fiscal Year: 2010
    ..The knowledge gained is expected to generate new ideas of how the proteome is regulated in select protists in response to external signals such as O2 and internal signals such as sugar metabolites. ..
  19. CYTOPLASMIC FUCOSYLATION
    Christopher West; Fiscal Year: 1993
    ..A rational interpretation of these analyses would benefit from an understanding of the multiple potential cellular origins of these substances...
  20. Structures and Functions of RNA Editing TUTases
    Ruslan Aphasizhev; Fiscal Year: 2011
    ..Targeting essential parasite-specific enzymes, such as mitochondrial RNA editing terminal uridylyl transferases (TUTases), is a promising approach toward a new generation of trypanocides. ..
  21. Analysis of the Plasmodium merozoite rhoptry proteome
    TOBILI SAM YELLOWE; Fiscal Year: 2006
    ..2) We will analyze rhoptries during schizont development by MudPIT analysis and evaluate the distribution of rhoptry proteins during rhoptry biogenesis. ..
  22. The Plastid of Toxoplasma gondii
    Marilyn Parsons; Fiscal Year: 2006
    ..The proposed experiments will provide additional insight into the biogenesis of the apicoplast and its importance to T. gondii and related pathogens. ..
  23. Molecular architecture, function and biogenesis of the ventral disc in Giardia in
    Scott C Dawson; Fiscal Year: 2010
    ..The research proposed here directly investigates the attachment mechanism of Giardia, and will offer additional targets for drug discovery. Specifically we investigate the function of the "ventral disc" a suction cup-like structure. ..
  24. Software tools for analysis and visulaization of protein structure
    Ethan A Merritt; Fiscal Year: 2010
    ..The algorithms and computation tools developed as part of this work will be distributed freely, and we will provide web-based state of the art analysis of structures submitted by external researchers. ..
  25. EXPANDED PROTEIN STRUCTURE REFINEMENT AND VALIDATION
    Ethan Merritt; Fiscal Year: 2005
    ..This, in turn, will make it easier to identify key biological features such as the presence and conformation of bound ligands, and the nature of hinge and inter-domain motions. ..
  26. MOLECULAR ANALYSIS OF THE GLYCOSOME.
    Marilyn Parsons; Fiscal Year: 2004
    ..Their studies are aimed at understanding glycosomal biogenesis and protein input and the relationship of these processes and the molecules involved to peroxisome biogenesis in the human host. ..
  27. PROTEIN PHOSPHORYLATION IN TRYPANOSOMES
    Marilyn Parsons; Fiscal Year: 2003
    ..Interwoven are studies of nucleolar function and proliferation. This will form a scaffold to which new findings can be linked, and allow phosphorylation pathways in T. brucei to be elucidated. ..
  28. Gut Epithelial Cell Receptors for C parvum Invasion
    ROBERTA O CONNOR; Fiscal Year: 2005
    ..New England Medical Center, in association with Tufts University and the wider Boston scientific community provides researchers with diverse and excellent scientific resources, and is exceptional environment for a young scientist...
  29. Protein Phosphorylation in Trypanososmes
    Marilyn Parsons; Fiscal Year: 2007
    ..Together these studies will significantly expand our knowledge of the network of signaling interactions in trypanosomes, with the goal of identifying new drug and vaccine targets. ..
  30. A new family of secreted adhesive proteins in Plasmodium
    THOMAS TEMPLETON; Fiscal Year: 2007
    ....
  31. RNA Uridylytransferases of Trypanosomes
    Ruslan Aphasizhev; Fiscal Year: 2007
    ..Sequences of the newly identified UTP-specific transferases will be used to establish characteristic protein motifs for this family of enzymes. ..
  32. Biology, immunology and therapy of Acanthamoeba keratitis
    Hassan Alizadeh; Fiscal Year: 2007
    ..The long-range goal of this project is to develop an anti-disease vaccine as a therapeutic adjunct for the management of Acanthamoeba keratitis. ..
  33. Role of Cryptosporidium Mucins in Host-parasite interactions
    ROBERTA O CONNOR; Fiscal Year: 2007
    ....
  34. Characterization of Proplasmepsin Maturase
    Daniel Goldberg; Fiscal Year: 2009
    ..The results obtained from our study should define a promising new drug target, with an eye towards future drug development. ..
  35. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2007
    ..gondii. Collectively, these aims will answer how TgGCN5 and its assocated molecules regulate transcription, significantly contributing to our knowledge about the gene regulatory circuitry in this group of important pathogens. ..
  36. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  37. BIOLOGY, IMMUNOLOGY & THERAPY OF ACANTHAMOEBA KERATITIS
    Hassan Alizadeh; Fiscal Year: 2009
    ....
  38. APEs as novel drug targets in AIDS opportunistic pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2007
    ..Toxoplasma is also listed by NIAID as a category B pathogen relevant to Biodefense research. Moreover, Toxoplasma can be informative as a model organism to study Plasmodium, the causative agent of malaria. ..