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Genomes and Genes
| env gene productsSummarySummary: Retroviral proteins, often glycosylated, coded by the envelope (env) gene. They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease. Top Publications
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Publications
Comparative immunogenicity of human immunodeficiency virus particles and corresponding polypeptides in a DNA vaccineWataru Akahata
Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892-3005, USA
J Virol 79:626-31. 2005..These data suggest that DNA vaccines encoding separated HIV polypeptides generate immune responses similar to those generated by viral particles...
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesisS Mi
Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
Nature 403:785-9. 2000..Our data indicate that syncytin may mediate placental cytotrophoblast fusion in vivo, and thus may be important in human placental morphogenesis...- Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelinationJoseph M Antony
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
Nat Neurosci 7:1088-95. 2004..Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention... - Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1Bing Li
Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
J Virol 80:5211-8. 2006.... - Transactivation of elements in the human endogenous retrovirus W family by viral infectionChristoffer Nellåker
The Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
Retrovirology 3:44. 2006.... - Identification of a major co-receptor for primary isolates of HIV-1H Deng
Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
Nature 381:661-6. 1996..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta... - The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retrovirusesS Bour
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
J Virol 70:8285-300. 1996..HIV-1 and HIV-2 thus appear to have evolved genetically distinct but functionally similar strategies to resolve the common problem of efficient release of progeny virus from infected cells... - The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]S Wyss
Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, Switzerland
J Virol 75:2982-92. 2001..Finally, the C-terminal dileucine was shown to assist the membrane-proximal Y712 motif in restricting the cell surface expression of Env... - The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytesJoseph M Antony
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
J Immunol 179:1210-24. 2007..These studies provide new insights into the role of HERV-mediated neuroinflammation and its contribution to an autoimmune disease... - Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infectionSimon D W Frost
Department of Pathology, University of California at San Diego, La Jolla, CA 92093 0679, USA
Proc Natl Acad Sci U S A 102:18514-9. 2005..Our results suggest that autologous neutralizing antibody responses may play a pivotal role in the diversification of HIV-1 envelope during the early stages of infection... - Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteinsC Berlioz-Torrent
CJF 97 03 INSERM, Interactions Moléculaires, Hôte Pathogène, Institut Cochin de Genetique Moleculaire, 75014 Paris, France
J Virol 73:1350-61. 1999.... - Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues--evidence for a function for envelope gene productsE Larsson
Department of Pathology, Uppsala University Hospital, Sweden
Ups J Med Sci 99:113-20. 1994.... - Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virusA D Miller
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
J Virol 65:2220-4. 1991..These simian virus-based packaging cells extend the host range of currently available murine and avian packaging cells and should be useful for efficient gene transfer into higher mammals... - Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiationJean Louis Frendo
Unité INSERM 427, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, 75006 Paris, France
Mol Cell Biol 23:3566-74. 2003..Taken together, these results strongly support a direct role for Env-W in human trophoblast cell fusion and differentiation... - HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5T Dragic
The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA
Nature 381:667-73. 1996..CC-CKR-5 is a second receptor for NSI primary viruses... - An inducible HIV type 1 gp41 HR-2 peptide-binding site on HIV type 1 envelope gp120S Munir Alam
Department of Medicine, Duke Center for AIDS Research, Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina 27707, USA
AIDS Res Hum Retroviruses 20:836-45. 2004..This may prove to be an important consideration when designing an HIV vaccine that utilizes constrained HIV Env proteins... - Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistanceXiaobin Lu
VIRxSYS Corporation, Gaithersburg, MD 20877, USA
J Virol 78:7079-88. 2004..These clones were not found to be escape mutants, as their replicative ability was severely attenuated, and they did not replicate in the presence of vector... - Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5C B Davis
Division of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, NYU Medical Center 10016, USA
J Exp Med 186:1793-8. 1997..The results presented here provide the first evidence for activation of an intracellular signaling event that can initiate multiple signaling pathways as a consequence of contact between HIV-1 and chemokine receptors... - Diversity considerations in HIV-1 vaccine selectionBrian Gaschen
Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Science 296:2354-60. 2002..Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half... - Perinatal transmission of major, minor, and multiple maternal human immunodeficiency virus type 1 variants in utero and intrapartumR E Dickover
Department of Pediatrics, UCLA School of Medicine, Los Angeles, California 90095, USA
J Virol 75:2194-203. 2001..These data indicate that different selective pressures, depending on the timing of transmission, may be involved in determining the pattern of maternal HIV-1 variant transmission... - Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infectionM R Betts
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
J Virol 75:11983-91. 2001..These results suggest that overall frequencies of HIV-specific T cells are not the sole determinant of immune-mediated protection in HIV-infection... - Amphotropic murine leukaemia virus envelope protein is associated with cholesterol-rich microdomainsChristiane Beer
Molecular Biotechnology, German Research Centre for Biotechnology, GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
Virol J 2:36. 2005..g., measles virus and human immunodeficiency virus. For these viruses association of newly synthesized viral proteins with lipid rafts has been shown... - Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesionsHervé Perron
bioMerieux, R and D, Chemin de l orme, 69280 Marcy l Etoile, France
J Neurovirol 11:23-33. 2005..This is compatible with a pathophysiological role in MS, but also illustrates the ambivalence of such HERV antigens, which can be expressed in cell-specific patterns, under physiological or pathological conditions... - Lack of effect of cytoplasmic tail truncations on human immunodeficiency virus type 2 ROD env particle release activityS P Bour
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
J Virol 73:778-82. 1999.... - Transgenic Fv-4 mice resistant to Friend virusT I Limjoco
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
J Virol 67:4163-8. 1993..The phenotype of recovery from viremia in Fv4-11 mice was unexpected and suggests that low levels of expression of the Fv-4 gene enhance the effectiveness of the immune response... - GCMa regulates the syncytin-mediated trophoblastic fusionChenchou Yu
Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan
J Biol Chem 277:50062-8. 2002..Our results may help to explain the mechanism underlying the cell fusion event specific for syncytiotrophoblast formation... - Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope proteinP L Earl
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
J Virol 65:2047-55. 1991..The results are discussed in terms of the overall biosynthetic pathway of the envelope protein and provide a framework with which to assess the effects of mutations on structure and function... - Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptionsBeda Joos
University Hospital Zurich, Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, , , Switzerland
J Virol 79:9026-37. 2005.... - Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placentaAlan Smallwood
Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London SE5 9RS, United Kingdom
Biol Reprod 69:286-93. 2003..Therefore, the relative levels of 3.1 kb and 8 kb mRNAs in trophoblasts could regulate syncytin protein synthesis, possibly by competition of the two mRNA species for translational apparatus... - Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophagesBrandon L Walter
Rocky Mountain Laboratories, 903 S. 4th St, Hamilton, MT 59840, USA
J Virol 79:4828-37. 2005..Thus, the limited expression of CD4 on macrophages or other cell types could serve as a selective factor for V1 and V2 envelope sequences, and this selection could in turn influence many aspects of AIDS pathogenesis in vivo... - Expression cloning of new receptors used by simian and human immunodeficiency virusesH K Deng
Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Howard Hughes Medical Institute, New York University Medical Center, New York 10016, USA
Nature 388:296-300. 1997..Usage of these new receptors following experimental infection of non-human primates with SIV strains may provide important insight into viral transmission and the mechanisms of SIV- and HIV-induced acquired immune-deficiency syndrome... - Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virusElena Chertova
AIDS Vaccine Program, SAIC Frederick, Maryland 21702 1201, USA
J Virol 76:5315-25. 2002..These findings suggest that incorporation of SU-TM complexes into the viral membrane may be the primary factor determining the quantity of SU associated with SIV and HIV-1 virions, rather than shedding of SU from mature virions... - Selective pressures of human immunodeficiency virus type 1 (HIV-1) during pediatric infectionElcio Leal
Federal University of Sao Paulo, Sao Paulo, Brazil
Infect Genet Evol 7:694-707. 2007..The second region, restricted to amino acids 334-368 of Gp160, contains sites that might increase viral fitness during interhost transmission at the population level... - Altered placental syncytin and its receptor ASCT2 expression in placental development and pre-eclampsiaC P Chen
Division of High Risk Pregnancy, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, and Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan
BJOG 113:152-8. 2006..To investigate the alterations of syncytin, a fusogenic membrane protein involved in syncytiotrophoblastic layer formation, and its receptor ASCT2 expression in placental development and pre-eclampsia... - Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1J Stitz
Department of Medical Biotechnology, Paul Ehrlich Institut, Langen, 63225, Germany
Virology 273:16-20. 2000..Thus, HIV-1(GaLV) and HIV-1(10A1) pseudotype vectors may be useful for efficient gene transfer into a variety of human tissues like primary human hematopoietic cells... - Use of different but overlapping determinants in a retrovirus receptor accounts for non-reciprocal interference between xenotropic and polytropic murine leukemia virusesNeal S Van Hoeven
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Retrovirology 2:76. 2005..NRI also occurs between xenotropic and polytropic MLV. The common receptor, Xpr1, has been identified, but a specific receptor has yet to be described... - Structural characterization of the fusion core in syncytin, envelope protein of human endogenous retrovirus family WRui Gong
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
Biochem Biophys Res Commun 331:1193-200. 2005..The fusion core structure of syncytin was first demonstrated in endogenous retrovirus. These results support the explanation how syncytin mediates cytotrophoblast cell fusion involved in placental morphogenesis... - The sequence complementarity between HIV-1 5' splice site SD4 and U1 snRNA determines the steady-state level of an unstable env pre-mRNAS Kammler
, , Germany
RNA 7:421-34. 2001..This suggests that the GAR sequences may play a role in stabilizing the pre-mRNA by sequestering U1 snRNP to SD4... - Mechanisms of viral membrane fusion and its inhibitionD M Eckert
Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, M I T, Cambridge, Massachusetts 02142, USA
Annu Rev Biochem 70:777-810. 2001..This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible... - Developmental expression of HERV-R (ERV3) and HERV-K in human tissueAnn Catrin Andersson
Department of Pathology, Uppsala University Hospital, Uppsala, Sweden
Virology 297:220-5. 2002..Pol/Int was not possible to quantitate. It appears that ERV3 is expressed in an organ-specific way during embryogenesis and might suggest a possible role in the development and differentiation of human tissues... - Functional characterization of the placental fusogenic membrane protein syncytinChingwen Chang
Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan
Biol Reprod 71:1956-62. 2004..Our results suggest that the cytoplasmic domain of syncytin is not essential for syncytin-mediated fusion but may play a regulatory role, and an intramolecular interaction between HRA and B is involved in the fusion process... - Role of HIV-2 envelope in Lv2-mediated restrictionSandra Reuter
Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany
Virology 332:347-58. 2005..A remaining restriction to infection (19-fold) is preserved when endosomal acidification is prevented. This restriction to infection is also dependent on the presence of the point mutation at position 74 (G74E)... - Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infectionDaniel Shriner
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070, USA
Genetics 166:1155-64. 2004..We conclude that the genetic variation in these data sets can be explained by a predominance of random genetic drift of neutral mutations with brief episodes of natural selection that were frequently masked by recombination... - An essential role for the His-8 residue of the SDF-1alpha-chimeric, tropism-redirected Env protein of the Moloney murine leukemia virus in regulating postbinding fusion eventsMasumi Katane
Molecular Cell Science Laboratory, Discovery Research Institute, RIKEN, Wako, Saitama 351-0198, Japan
J Gene Med 6:260-7. 2004.... - Structural and immunogenicity analysis of chimeric B-cell epitope constructs derived from the gp46 and gp21 subunits of the envelope glycoproteins of HTLV-1R Sundaram
Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH 43210, USA
J Pept Res 63:132-40. 2004..The applicability of a chimeric approach is discussed in the context of recent findings regarding the role of gp21 transmembrane region in the viral fusion process... - M-PMV capsid transport is mediated by Env/Gag interactions at the pericentriolar recycling endosomeJeffrey N Sfakianos
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Traffic 4:671-80. 2003..Thus, for the first time, endocytic trafficking of a retroviral Env glycoprotein is linked to the efficient cytoplasmic transport of Gag... - Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirusAlla Danilkovitch-Miagkova
Laboratory of Immunobiology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 100:4580-5. 2003..We find activated RON in a subset of human bronchioloalveolar carcinoma tumors, suggesting RON involvement in this type of human lung cancer... - The avian retrovirus avian sarcoma/leukosis virus subtype A reaches the lipid mixing stage of fusion at neutral pHLaurie J Earp
Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
J Virol 77:3058-66. 2003..Possible roles for low pH at subsequent stages of viral entry are discussed... - HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formationRuben M Markosyan
Department of Molecular Biophysics and Physiology, Rush Medical College, Chicago, Illinois 60612, USA
Mol Biol Cell 14:926-38. 2003..It is concluded that an essential function of the bundle is to stabilize the pore against collapse and ensure its growth... - Determinants of high titer in recombinant porcine endogenous retrovirusesIan Harrison
National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
J Virol 78:13871-9. 2004..Taken together, these results show that the novel juxtaposition of env gene sequences enhanced the infectivity of PERV-A14/220 for human cells, perhaps by stabilization of the envelope glycoprotein or increased receptor binding... - HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cellsC Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 97:1178-83. 2000..En-velope treatment of lymphocytes led to the cleavage of FAK in a manner consistent with caspase-mediated cleavage... - Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptorD Weissman
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 389:981-5. 1997..Alternatively, envelope-mediated CCR5 signal transduction may influence viral-associated cytopathicity or apoptosis... - CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursorB Crise
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510 8023
J Virol 64:5585-93. 1990.... - Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entryZ Chen
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
J Virol 71:2705-14. 1997..These findings indicated that, in addition to CCR5, SIV can use one or more unknown coreceptors that are expressed on human PBMCs and CEMx174 cells... - Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheepMarco Caporale
Institute of Comparative Medicine, University of Glasgow Veterinary School, 464 Bearsden Road, Glasgow G61 1QH, Scotland
J Virol 80:8030-7. 2006..These data strongly suggest that the JSRV Env functions as a dominant oncoprotein in the natural immunocompetent host and that JSRV can induce OPA in the absence of viral spread... - Prognostic role of syncytin expression in breast cancerLars Inge Larsson
Department of Anatomy and Cell Biology, IBHV, KVL, Frederiksberg C, Copenhagen, Denmark
Hum Pathol 38:726-31. 2007..Thus, syncytin expression constitutes a positive prognostic factor in breast cancer--a phenomenon that may be related to the involvement of syncytin in mediating fusions between breast cancer cells and endothelial cells... - Low pH is required for avian sarcoma and leukosis virus Env-induced hemifusion and fusion pore formation but not for pore growthG B Melikyan
Department of Molecular Biophysics and Physiology, Rush Medical College, Chicago, Illinois 60612, USA
J Virol 78:3753-62. 2004..At this point, but not before, low pH can induce fusion and is in fact required for fusion to occur. However, low pH is no longer necessary after formation of the initial fusion pore: pore enlargement does not require low pH... - Quantitative analysis of human endogenous retrovirus-W env in neuroinflammatory diseasesJoseph M Antony
Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
AIDS Res Hum Retroviruses 22:1253-9. 2006..033 log10/ml versus MS: 2.9 log10/ml). These observations emphasize the selective induction of syncytin-1 in brain tissue of MS patients but also illustrate the complex dynamics of this retroelement in neuroinflammatory processes... - Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of diseaseHong Zhang
Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA
Retrovirology 3:73. 2006..We investigated the possible influence of viral genotype and humoral immune response on disease progression in infants... - CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicityBridget A Puffer
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Virol 76:2595-605. 2002..Finally, genetic modification of viral Envs to enhance CD4 independence may also result in improved humoral immune responses... - Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteinsB Kobe
St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
Proc Natl Acad Sci U S A 96:4319-24. 1999..The structure of gp21 implies that the N-terminal fusion peptide is in close proximity to the C-terminal transmembrane domain and likely represents a postfusion conformation... - Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virusRika Draenert
Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Exp Med 203:529-39. 2006..These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape... - Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4R L Willey
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
J Virol 66:7193-200. 1992.... - CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissuesMagda Matouskova
Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo námìstí 2, 16637 Prague 6, Czech Republic
Exp Cell Res 312:1011-20. 2006.... - Characterization of human immunodeficiency virus type 1 from a previously unexplored region of South Africa with a high HIV prevalencePascal Obong Bessong
Department of Microbiology, University of Venda, Thohoyandou, South Africa
AIDS Res Hum Retroviruses 21:103-9. 2005..These data suggest that HIV-1 subtype C is the predominant subtype circulating in the Limpopo Province, and that viral strains from this region are indistinguishable from those found in other parts of South Africa... - Protection of rhesus monkeys against infection with minimally pathogenic simian-human immunodeficiency virus: correlations with neutralizing antibodies and cytotoxic T cellsGerald V Quinnan
Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
J Virol 79:3358-69. 2005..Induction of cross-reactive, primary HIV-1-neutralizing antibodies is feasible and, when potent, may result in complete protection against infection with a heterologous challenge virus strain... - Human immunodeficiency virus-like particles activate multiple types of immune cellsGangadhara Sailaja
Emory Vaccine Center and Department of Microbiology and Immunology, Rollins Research Center 3086, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
Virology 362:331-41. 2007..VLPs containing FL were an effective form of antigen in activating immune cells via dendritic cells, and immunization with HIV VLPs containing FL resulted in enhanced T helper type 2-like immune responses... - Genetic and biologic characterization of HIV type 1 subtype C isolates from south BrazilJoana P Monteiro
Laboratório Avançado de Saúde Pública, Centro de Pesquisa Gonçalo Moniz, Fundacao Oswaldo Cruz, Salvador, Bahia, Brazil
AIDS Res Hum Retroviruses 23:135-43. 2007..Biological characterization confirms the hypothesis that subtype C is distinct from the others in the evolution of coreceptor utilization... - Sequential priming and boosting with heterologous HIV immunogens predominantly stimulated T cell immunity against conserved epitopesJianqing Xu
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS STD Control and Prevention NCAIDS, Beijing, China
AIDS 20:2293-303. 2006..The effort to develop an effective preventive vaccine against HIV-1 infection is challenged by the wide genetic diversity of HIV-1 among different isolates... 
Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinantYaoxing Huang
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
J Acquir Immune Defic Syndr 47:403-11. 2008..A phase 1 clinical trial of this product has been successfully completed, and its use in prime-boost studies is now underway...- Immunogenicity of virus-like particles containing modified human immunodeficiency virus envelope proteinsFu Shi Quan
Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322, United States
Vaccine 25:3841-50. 2007..Therefore, this study suggests that VLPs containing modified HIV Env have the potential to be developed as candidate vaccines capable of inducing cellular and humoral immune responses including neutralizing activities... - Immunogenicity of attenuated vesicular stomatitis virus vectors expressing HIV type 1 Env and SIV Gag proteins: comparison of intranasal and intramuscular vaccination routesMichael A Egan
Wyeth Vaccines Research, Pearl River, New York 10965, USA
AIDS Res Hum Retroviruses 20:989-1004. 2004.... - Standardized assessment of NAb responses elicited in rhesus monkeys immunized with single- or multi-clade HIV-1 envelope immunogensMichael S Seaman
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, 330 Brookline Ave RE 204, Boston, MA 02215, USA
Virology 367:175-86. 2007.... - Susceptibility of recently transmitted subtype B human immunodeficiency virus type 1 variants to broadly neutralizing antibodiesEsther D Quakkelaar
Department of Clinical Viro Immunology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
J Virol 81:8533-42. 2007.... - HIV type 1 vaccines for worldwide use: predicting in-clade and cross-clade breadth of immune responsesAdam C Finnefrock
Vaccine and Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
AIDS Res Hum Retroviruses 23:1283-92. 2007..For more diverse proteins, adding a second strain can add a significant increase in breadth, although for three or more strains the intrinsic diversity of the protein leads to diminishing improvement... - Design, construction, and characterization of a multigenic modified vaccinia Ankara candidate vaccine against human immunodeficiency virus type 1 subtype C/B'Zhiwei Chen
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
J Acquir Immune Defic Syndr 47:412-21. 2008..ADMVA has since been advanced into clinical trials. A phase 1 study has been completed, and a prime-boost with ADVAX (see accompanying article) is now underway... - Comparison of HIV Type 1 ADA gp120 monomers versus gp140 trimers as immunogens for the induction of neutralizing antibodiesMikyung Kim
Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
AIDS Res Hum Retroviruses 21:58-67. 2005..This ADAgp140 immunogen may be considered a starting point from which to engineer additional improvements for cross-reactive neutralizing antibody induction... - Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccineAndrew T Catanzaro
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Building 40, Bethesda, MD 20892 3017, USA
Vaccine 25:4085-92. 2007..Compared to a four-plasmid product, Gag- and Nef-specific T cell responses were improved, while Env-specific responses were maintained. This candidate vaccine has now advanced to Phase II evaluation... - Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaquePhilip M McKenna
Department of Microbiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
J Virol 78:13455-9. 2004..6P). There was no evidence of CD4(+) T-cell loss, and plasma viremia was controlled to undetectable levels by 6 weeks postchallenge and has remained suppressed out to 22 weeks postchallenge... - Specific amino acids in the N-terminus of the gp41 ectodomain contribute to the stabilization of a soluble, cleaved gp140 envelope glycoprotein from human immunodeficiency virus type 1Antu K Dey
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Room W 805, New York, NY 10021, USA
Virology 360:199-208. 2007..The ability to increase the stability of gp140 trimers might be useful for neutralizing antibody-based vaccine strategies based on the use of this type of immunogen... - Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusionElaine R Thomas
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
Virology 360:105-19. 2007.... - Evaluation of envelope vaccines derived from the South African subtype C human immunodeficiency virus type 1 TV1 strainYing Lian
Chiron Corp, 4560 Horton St, 4 3, Emeryville, CA 94608
J Virol 79:13338-49. 2005..The pilot-scale production of the various TV1 DNA vaccine constructs and env proteins described here should provide an initial platform upon which to improve the immunogenicity of these subtype C HIV envelope vaccines... - A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1 (HIV-1)(HXB2) Rev/Env or codon-optimized HIV-1(JR-FL) gp120 generates durable immune responses in miceViviana Buffa
National AIDS Center, Department of Drugs and Evaluation, Istituto Superiore di Sanit, Viale Regina Elena 299, 00161, Rome, Italy
J Gen Virol 87:1625-34. 2006..These data provide the first evidence that a single, direct, in vivo administration of a lentiviral vector encoding a viral gene might represent a useful strategy for vaccine development... - Ancestral and consensus envelope immunogens for HIV-1 subtype CDenise L Kothe
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Virology 352:438-49. 2006..These results establish the utility of centralized HIV-1 subtype C Env immunogens and warrant their continued evaluation as potential components of future AIDS vaccines... - Development of V2-deleted trimeric envelope vaccine candidates from human immunodeficiency virus type 1 (HIV-1) subtypes B and CSusan W Barnett
Vaccines Research Department, Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608, USA
Microbes Infect 7:1386-91. 2005.... - Induction of neutralizing antibodies against human immunodeficiency virus type 1 primary isolates by Gag-Env pseudovirion immunizationJason Hammonds
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Virol 79:14804-14. 2005.... - Preclinical evaluation of cellular immune responses elicited by a polyvalent DNA prime/protein boost HIV-1 vaccineAnthony D Cristillo
Advanced BioScience Laboratories, Department of Cell Biology, 5510 Nicholson Lane, Kensington, MD 20895, USA
Virology 346:151-68. 2006.... - Immunization with HIV-1 SF162-derived Envelope gp140 proteins does not protect macaques from heterologous simian-human immunodeficiency virus SHIV89.6P infectionRong Xu
Seattle Biomedical Research Institute, Seattle, WA 98109, USA
Virology 349:276-89. 2006..Our results suggest that even small differences in HIV Envelope immunogen structure can affect the neutralizing antibody responses generated following infection... - Development of a candidate DNA/MVA HIV-1 subtype C vaccine for IndiaSanjeev Kumar
Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India
Vaccine 24:2585-93. 2006..This is the first reported candidate HIV-1 DNA/MVA vaccine employing the Indian subtype C sequences and constitutes a part of a vaccine scheduled to enter a preclinical non-human primate evaluation in India... - Neutralization and infectivity characteristics of envelope glycoproteins from human immunodeficiency virus type 1 infected donors whose sera exhibit broadly cross-reactive neutralizing activityFatim Cham
Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Virology 347:36-51. 2006.... - Human immunodeficiency virus type 1 subtype B ancestral envelope protein is functional and elicits neutralizing antibodies in rabbits similar to those elicited by a circulating subtype B envelopeN A Doria-Rose
Seattle Biomedical Research Institute, Washington, USA
J Virol 79:11214-24. 2005..The results were similar for rabbits immunized in parallel with a natural isolate, HIV-1 SF162. Further design efforts to better present conserved neutralization determinants are warranted... - Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidatesBarton F Haynes
Box 3258, RP 1 Building, Building 107, Circuit Drive, Duke University Medical Center, Durham, NC 27710, USA
Expert Rev Vaccines 5:347-63. 2006.... - Impact of natural polymorphism within the gp41 cytoplasmic tail of human immunodeficiency virus type 1 on the intracellular distribution of envelope glycoproteins and viral assemblyMarie Lambelé
Universite Francois Rabelais, Tours, France
J Virol 81:125-40. 2007..Thus, polymorphisms in primary HIV-1 gp41 CTs at the quasispecies or subtype level can influence the intracellular distribution of Env, its incorporation into virions, and viral replication capacity... - The C108g epitope in the V2 domain of gp120 functions as a potent neutralization target when introduced into envelope proteins derived from human immunodeficiency virus type 1 primary isolatesAbraham Pinter
Laboratory of Retroviral Biology, Public Health Research Institute, 225 Warren Street, Newark, NJ 07103 3535, USA
J Virol 79:6909-17. 2005.... - A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary virusesHua Xin Liao
Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA
Virology 353:268-82. 2006..Our study also shows the feasibility of iterative improvements in Env immunogenicity by rational design of centralized genes... - Immunology. Close to the edge: neutralizing the HIV-1 envelopeGary J Nabel
Vaccine Research Center (VRC, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Science 308:1878-9. 2005 - Membrane embedded HIV-1 envelope on the surface of a virus-like particle elicits broader immune responses than soluble envelopesSean P McBurney
Center for Vaccine Research for Emerging Diseases and Biodefense, University of Pittsburgh School of Medicine, 9047 Biomedical Sciences Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
Virology 358:334-46. 2007..These lentiviral VLPs are effective mucosal immunogens that elicit broader immunity against Env determinants in both the systemic and mucosal immune compartments than soluble forms of Env... - Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesMing Li
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Virol 79:10108-25. 2005..These reference reagents will facilitate proficiency testing and other validation efforts aimed at improving assay performance across laboratories and can be used for standardized assessments of vaccine-elicited neutralizing antibodies... - Molecular characteristics of HIV type 1 circulating in São Paulo, BrazilLuis F M Brigido
Retrovirus Laboratory, Virology Service, Adolfo Lutz Institute, Sao Paulo, Brazil
AIDS Res Hum Retroviruses 21:673-82. 2005..A mosaic pol was observed in 9%, all B/F except for one G mosaic. A CRF-12-BF structure, observed in 20% of B/F pol mosaics, provides evidence for an epidemic relationship in the major South American metropolitan areas... - Antibody responses elicited in macaques immunized with human immunodeficiency virus type 1 (HIV-1) SF162-derived gp140 envelope immunogens: comparison with those elicited during homologous simian/human immunodeficiency virus SHIVSF162P4 and heterologous HNina R Derby
Seattle Biomedical Research Institute, WA 98109, USA
J Virol 80:8745-62. 2006.... - Cytolytic T lymphocytes (CTLs) from HIV-1 subtype C-infected Indian patients recognize CTL epitopes from a conserved immunodominant region of HIV-1 Gag and NefMadhuri R Thakar
National AIDS Research Institute, Bhosari, Pune, India
J Infect Dis 192:749-59. 2005..Three Gag and 4 Nef epitopes were novel. The identification of conserved epitopes will be important in the planning of an HIV-1 vaccine strategy for subtype C-affected regions...
Research Grants
- Nipah Virus Pathobiology and Effects on Innate ImmunityLinda Baum; Fiscal Year: 2009..The co-investigators have a unique combination of expertise, and propose an innovative set of studies into the glycobiology of NiV pathogenesis. ..
- THE ENVELOPE GENE PRODUCTS OF MURINE LEUKEMIA VIRUSMONICA ROTH; Fiscal Year: 1993..The viral gene products which are known to be required for the entry of the virus into the cells (env gene products) will be studied genetically and biochemically...
- LEUKEMOGENIC RETROVIRAL GLYCOPROTEIN: GP55-GP70SDavid Kabat; Fiscal Year: 1993..The murine model has unique experimental advantages...
- Intersubtype recombinants for polyvalent anti-HIV vaccineYong Gao; Fiscal Year: 2009....
- Mechanism of p12I and p30II in HTLV1 InfectionMichael Lairmore; Fiscal Year: 2003..This complex retrovirus encodes typical gag, pol, and env gene products, as well as unique regulatory and accessory genes encoded in pX ORF I-IV between the env gene and the 3' LTR...
- Intersubtype recombinants for polyvalent anti-HIV vaccineYong Gao; Fiscal Year: 2010....
- Novel HIV-1 vaccine candidates using newly transmitted clade C Envs as immunogensJerry Blackwell; Fiscal Year: 2007....
- DNA Vaccines With HIV Virus-like ParticlesTed Ross; Fiscal Year: 2003..elicit both humoral and cell-mediated immune responses to the major structural proteins of HIV, the Gag and Env gene products. The VLP has safety mutations designed into vaccine in order to meet U.S...
- Endogenous retroviruses and gene regulation after injuryKiho Cho; Fiscal Year: 2010..Furthermore, the findings from this study may lead to a further investigation into the development of a novel therapeutic protocol for burn patients in combination with current regimens. ..
- LEUKEMOGENIC MEMBRANE GLYCOPROTEINS: GP55S OF SFFVSDavid Kabat; Fiscal Year: 1991..forming virus (SFFV) encodes a membranes glycoprotein (gp55) which is structurally related to the larger env gene products of recombinant-type dualtropic MCF viruses, that gp55 causes mitosis of infected erythroblasts, and that the ..
- CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLSJohn Young; Fiscal Year: 2004..Understanding this process in detail should lead to better antiviral therapeutic strategies and aid with viral targeting approaches for gene therapy protocols. ..
- Creation of Stable Cleaved Trimers of the HIV-1 Envelope ProteinRobert Whalen; Fiscal Year: 2006....