env gene products

Summary

Summary: Retroviral proteins, often glycosylated, coded by the envelope (env) gene. They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease.

Top Publications

  1. pmc Comparative immunogenicity of human immunodeficiency virus particles and corresponding polypeptides in a DNA vaccine
    Wataru Akahata
    Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892 3005, USA
    J Virol 79:626-31. 2005
  2. ncbi Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
    S Mi
    Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
    Nature 403:785-9. 2000
  3. pmc Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins
    Marianne Mangeney
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, F 94805 Villejuif, France
    Proc Natl Acad Sci U S A 104:20534-9. 2007
  4. ncbi Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta
    Reiner Strick
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054, Erlangen, Germany
    J Mol Med (Berl) 85:23-38. 2007
  5. ncbi Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen
    N Sutkowski
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    Immunity 15:579-89. 2001
  6. pmc Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease
    S R Broussard
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    J Virol 75:2262-75. 2001
  7. pmc Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1
    Bing Li
    Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
    J Virol 80:5211-8. 2006
  8. ncbi The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses
    Alexandre Rolland
    Laboratoire d Immunochimie, Institut National de la Santé et de la Recherche Médicale Unité 548, Commissariat a l Energie Atomique, Grenoble, France
    J Immunol 176:7636-44. 2006
  9. ncbi Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 7:1088-95. 2004
  10. ncbi Expression analyses of human endogenous retroviruses (HERVs): tissue-specific and developmental stage-dependent expression of HERVs
    Goichi Okahara
    Department of Molecular Biology, Ryukyu University School of Medicine, 207 Uehara, Okinawa 903 0215, Japan
    Genomics 84:982-90. 2004

Detail Information

Publications216 found, 100 shown here

  1. pmc Comparative immunogenicity of human immunodeficiency virus particles and corresponding polypeptides in a DNA vaccine
    Wataru Akahata
    Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892 3005, USA
    J Virol 79:626-31. 2005
    ..These data suggest that DNA vaccines encoding separated HIV polypeptides generate immune responses similar to those generated by viral particles...
  2. ncbi Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
    S Mi
    Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
    Nature 403:785-9. 2000
    ..Our data indicate that syncytin may mediate placental cytotrophoblast fusion in vivo, and thus may be important in human placental morphogenesis...
  3. pmc Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins
    Marianne Mangeney
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, F 94805 Villejuif, France
    Proc Natl Acad Sci U S A 104:20534-9. 2007
    ..Selective inactivation of immunosuppression, under conditions not affecting fusogenicity, should be important for understanding the role of this function in placental physiology and maternofetal tolerance...
  4. ncbi Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta
    Reiner Strick
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054, Erlangen, Germany
    J Mol Med (Berl) 85:23-38. 2007
    ..Interactions between Syncytin-1 and TGF-beta may contribute to the etiology of EnCa progression and also help to clarify the regulation of cell-cell fusions occurring in development and in other syncytial cell tumors...
  5. ncbi Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen
    N Sutkowski
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    Immunity 15:579-89. 2001
    ..The T cell activation elicited by the Sag could play a central role in EBV infection and associated diseases...
  6. pmc Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease
    S R Broussard
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    J Virol 75:2262-75. 2001
    ....
  7. pmc Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1
    Bing Li
    Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
    J Virol 80:5211-8. 2006
    ....
  8. ncbi The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses
    Alexandre Rolland
    Laboratoire d Immunochimie, Institut National de la Santé et de la Recherche Médicale Unité 548, Commissariat a l Energie Atomique, Grenoble, France
    J Immunol 176:7636-44. 2006
    ..Finally, ENV-SU endowed dendritic cells with the capacity to support a Th1-like type of Th cell differentiation. The data are discussed in the context of immune responses and chronic proinflammatory disorders...
  9. ncbi Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 7:1088-95. 2004
    ..Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention...
  10. ncbi Expression analyses of human endogenous retroviruses (HERVs): tissue-specific and developmental stage-dependent expression of HERVs
    Goichi Okahara
    Department of Molecular Biology, Ryukyu University School of Medicine, 207 Uehara, Okinawa 903 0215, Japan
    Genomics 84:982-90. 2004
    ..Term placentas in general showed larger interindividual differences in HERV expression levels. Our results suggest that HERVs might have more diverse effects than currently thought...
  11. ncbi Mechanisms of viral membrane fusion and its inhibition
    D M Eckert
    Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, M I T, Cambridge, Massachusetts 02142, USA
    Annu Rev Biochem 70:777-810. 2001
    ..This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible...
  12. pmc Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection
    Simon D W Frost
    Department of Pathology, University of California at San Diego, La Jolla, CA 92093 0679, USA
    Proc Natl Acad Sci U S A 102:18514-9. 2005
    ..Our results suggest that autologous neutralizing antibody responses may play a pivotal role in the diversification of HIV-1 envelope during the early stages of infection...
  13. pmc Transactivation of elements in the human endogenous retrovirus W family by viral infection
    Christoffer Nellåker
    The Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Retrovirology 3:44. 2006
    ....
  14. ncbi Identification of a major co-receptor for primary isolates of HIV-1
    H Deng
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
    Nature 381:661-6. 1996
    ..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta...
  15. ncbi Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity
    Y Stauffer
    Department of Genetics and Microbiology, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Immunity 15:591-601. 2001
    ..Endogenous SAgs induced via IFN-alpha by viral infections is a novel mechanism through which environmental factors may cause disease in genetically susceptible individuals...
  16. pmc Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein
    P L Earl
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 65:2047-55. 1991
    ..The results are discussed in terms of the overall biosynthetic pathway of the envelope protein and provide a framework with which to assess the effects of mutations on structure and function...
  17. ncbi Expression of the human endogenous retrovirus-K transmembrane envelope, Rec and Np9 proteins in melanomas and melanoma cell lines
    Kristina Büscher
    Robert Koch Institute, Berlin, Germany
    Melanoma Res 16:223-34. 2006
    ..Additional experiments are needed to determine their involvement, if any, in cell proliferation and tumor progression...
  18. ncbi Determinants of foamy virus envelope glycoprotein mediated resistance to superinfection
    Angelika Berg
    Institut fur Virologie und Immunbiologie, Universitat Wurzburg, 97078 Wurzburg, Germany
    Virology 314:243-52. 2003
    ..This implies that all of them use the same receptor molecules for viral entry...
  19. ncbi Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design
    P W Parren
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Lett 57:105-12. 1997
    ..Potential vaccines should be designed to elicit responses against native envelope...
  20. pmc CD4-induced T-20 binding to human immunodeficiency virus type 1 gp120 blocks interaction with the CXCR4 coreceptor
    Wen Yuan
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Virol 78:5448-57. 2004
    ..Interactions between the gp41 HR2 region and coreceptor-binding regions of gp120 may also play a role in the function of the HIV-1 envelope glycoproteins...
  21. ncbi The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Immunol 179:1210-24. 2007
    ..These studies provide new insights into the role of HERV-mediated neuroinflammation and its contribution to an autoimmune disease...
  22. ncbi Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions
    Hervé Perron
    bioMerieux, R and D, Chemin de l orme, 69280 Marcy l Etoile, France
    J Neurovirol 11:23-33. 2005
    ..This is compatible with a pathophysiological role in MS, but also illustrates the ambivalence of such HERV antigens, which can be expressed in cell-specific patterns, under physiological or pathological conditions...
  23. ncbi An inducible HIV type 1 gp41 HR-2 peptide-binding site on HIV type 1 envelope gp120
    S Munir Alam
    Department of Medicine, Duke Center for AIDS Research, Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina 27707, USA
    AIDS Res Hum Retroviruses 20:836-45. 2004
    ..This may prove to be an important consideration when designing an HIV vaccine that utilizes constrained HIV Env proteins...
  24. pmc Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection
    M R Betts
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Virol 75:11983-91. 2001
    ..These results suggest that overall frequencies of HIV-specific T cells are not the sole determinant of immune-mediated protection in HIV-infection...
  25. pmc Intracellular trafficking of Gag and Env proteins and their interactions modulate pseudotyping of retroviruses
    Virginie Sandrin
    Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, INSERM U412, IFR128 Biosciences Lyon Gerland, Ecole Normal Supérieure de Lyon, France
    J Virol 78:7153-64. 2004
    ..Thus, intracellular colocalization, as well as interactions between Env and core proteins, may influence the recruitment of the glycoprotein onto viral particles and generate infectious pseudotyped viruses...
  26. pmc Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation
    Jean Louis Frendo
    Unité INSERM 427, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, 75006 Paris, France
    Mol Cell Biol 23:3566-74. 2003
    ..Taken together, these results strongly support a direct role for Env-W in human trophoblast cell fusion and differentiation...
  27. ncbi Retroviral genomic RNAs are transported to the plasma membrane by endosomal vesicles
    Eugenia Basyuk
    IGMM CNRS UMR5535, Universite Montpellier II, IFR 24, 1919, route de Mende, 34293 Cedex 5, Montpellier, France
    Dev Cell 5:161-74. 2003
    ..This may allow retroviruses to hijack the endosomal machinery as part of their biosynthetic pathway. More generally, tethering to vesicles may provide an efficient mechanism for directed RNA transport...
  28. ncbi Detecting the expression of human endogenous retrovirus E envelope transcripts in human prostate adenocarcinoma
    Feng Wang-Johanning
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer 98:187-97. 2003
    ..The authors report that, in the current study, transcripts encoding the envelope region of an HERV family, HERV-E, were expressed in human prostate carcinoma...
  29. pmc Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins
    C Berlioz-Torrent
    CJF 97 03 INSERM, Interactions Moléculaires, Hôte Pathogène, Institut Cochin de Genetique Moleculaire, 75014 Paris, France
    J Virol 73:1350-61. 1999
    ....
  30. pmc Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus
    A D Miller
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    J Virol 65:2220-4. 1991
    ..These simian virus-based packaging cells extend the host range of currently available murine and avian packaging cells and should be useful for efficient gene transfer into higher mammals...
  31. ncbi Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues--evidence for a function for envelope gene products
    E Larsson
    Department of Pathology, Uppsala University Hospital, Sweden
    Ups J Med Sci 99:113-20. 1994
    ....
  32. pmc Wild-type-like viral replication potential of human immunodeficiency virus type 1 envelope mutants lacking palmitoylation signals
    Woan Eng Chan
    Institute of Biomedical Sciences, Academia Sinica, 128 Yen Chiu Yuan Road, Section 2, Nankang, Taipei 11529, Taiwan, Republic of China
    J Virol 79:8374-87. 2005
    ..Our results together support the notion that palmitoylation of the cytoplasmic tail of the HIV-1 Env is not essential for the HIV-1 virus life cycle...
  33. pmc Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5
    C B Davis
    Division of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, NYU Medical Center 10016, USA
    J Exp Med 186:1793-8. 1997
    ..The results presented here provide the first evidence for activation of an intracellular signaling event that can initiate multiple signaling pathways as a consequence of contact between HIV-1 and chemokine receptors...
  34. ncbi HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    T Dragic
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA
    Nature 381:667-73. 1996
    ..CC-CKR-5 is a second receptor for NSI primary viruses...
  35. pmc Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance
    Xiaobin Lu
    VIRxSYS Corporation, Gaithersburg, MD 20877, USA
    J Virol 78:7079-88. 2004
    ..These clones were not found to be escape mutants, as their replicative ability was severely attenuated, and they did not replicate in the presence of vector...
  36. ncbi Syncytin is involved in breast cancer-endothelial cell fusions
    B Bjerregaard
    Anatomy and Cell Biology, IBHV, KVL, Gronnegaardsvej 7, 1870 Frederiksberg C, Copenhagen, Denmark
    Cell Mol Life Sci 63:1906-11. 2006
    ..Moreover, a syncytin inhibitory peptide also inhibits fusions between cancer and endothelial cells. These results are the first to show that syncytin is expressed by human cancer cells and is involved in cancer-endothelial cell fusions...
  37. pmc The avian retrovirus avian sarcoma/leukosis virus subtype A reaches the lipid mixing stage of fusion at neutral pH
    Laurie J Earp
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 77:3058-66. 2003
    ..Possible roles for low pH at subsequent stages of viral entry are discussed...
  38. ncbi Relation between phylogeny of African green monkey CD4 genes and their respective simian immunodeficiency virus genes
    A Fomsgaard
    Statens Serum Institut, Technical University of Denmark, Copenhagen, Denmark
    J Med Primatol 26:120-8. 1997
    ..CD4 sequencing is suggested as a relevant method for genetic determination of primate species...
  39. ncbi M-PMV capsid transport is mediated by Env/Gag interactions at the pericentriolar recycling endosome
    Jeffrey N Sfakianos
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Traffic 4:671-80. 2003
    ..Thus, for the first time, endocytic trafficking of a retroviral Env glycoprotein is linked to the efficient cytoplasmic transport of Gag...
  40. pmc Lack of effect of cytoplasmic tail truncations on human immunodeficiency virus type 2 ROD env particle release activity
    S P Bour
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 73:778-82. 1999
    ....
  41. pmc Transgenic Fv-4 mice resistant to Friend virus
    T I Limjoco
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:4163-8. 1993
    ..The phenotype of recovery from viremia in Fv4-11 mice was unexpected and suggests that low levels of expression of the Fv-4 gene enhance the effectiveness of the immune response...
  42. pmc Amphotropic murine leukaemia virus envelope protein is associated with cholesterol-rich microdomains
    Christiane Beer
    Molecular Biotechnology, German Research Centre for Biotechnology, GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Virol J 2:36. 2005
    ..g., measles virus and human immunodeficiency virus. For these viruses association of newly synthesized viral proteins with lipid rafts has been shown...
  43. ncbi Recombination: Multiply infected spleen cells in HIV patients
    Andreas Jung
    Department of Virology, University of the Saarland, 66421 Homburg, Germany
    Nature 418:144. 2002
    ..Although this creates problems for phylogenetic analyses, which ignore recombination effects, the intracellular variation may help to broaden immune recognition...
  44. ncbi The M-PMV cytoplasmic targeting-retention signal directs nascent Gag polypeptides to a pericentriolar region of the cell
    Jeffrey N Sfakianos
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Traffic 4:660-70. 2003
    ..Thus the previously defined cytoplasmic targeting-retention signal appears to act as a cotranslational intracellular targeting signal that concentrates Gag proteins at the centriole for assembly of capsids...
  45. ncbi Diversity considerations in HIV-1 vaccine selection
    Brian Gaschen
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 296:2354-60. 2002
    ..Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half...
  46. ncbi Correlation between disease severity and in vitro cytokine production mediated by MSRV (multiple sclerosis associated retroviral element) envelope protein in patients with multiple sclerosis
    Alexandre Rolland
    Laboratoire d Immunochimie, CEA INSERM U548, 17 rue des Martyrs 38054 Grenoble, France
    J Neuroimmunol 160:195-203. 2005
    ..Altogether our data suggest that MSRV envelope protein may induce an abnormal cytokine secretion, thus contributing to the inflammatory process in MS...
  47. pmc Perinatal transmission of major, minor, and multiple maternal human immunodeficiency virus type 1 variants in utero and intrapartum
    R E Dickover
    Department of Pediatrics, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 75:2194-203. 2001
    ..These data indicate that different selective pressures, depending on the timing of transmission, may be involved in determining the pattern of maternal HIV-1 variant transmission...
  48. pmc Sequential roles of receptor binding and low pH in forming prehairpin and hairpin conformations of a retroviral envelope glycoprotein
    Shutoku Matsuyama
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
    J Virol 78:8201-9. 2004
    ....
  49. pmc The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]
    S Wyss
    Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, Switzerland
    J Virol 75:2982-92. 2001
    ..Finally, the C-terminal dileucine was shown to assist the membrane-proximal Y712 motif in restricting the cell surface expression of Env...
  50. pmc Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
    Maria Castedo
    Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    EMBO J 21:4070-80. 2002
    ..Cdk1 inhibition prevents the death of syncytia elicited by HIV-1 infection of primary CD4 lymphoblasts. Thus, HIV-1 elicits a pro-apoptotic signal transduction pathway relying on the sequential action of cyclin B-Cdk1, mTOR and p53...
  51. pmc The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses
    S Bour
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 70:8285-300. 1996
    ..HIV-1 and HIV-2 thus appear to have evolved genetically distinct but functionally similar strategies to resolve the common problem of efficient release of progeny virus from infected cells...
  52. ncbi GCMa regulates the syncytin-mediated trophoblastic fusion
    Chenchou Yu
    Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan
    J Biol Chem 277:50062-8. 2002
    ..Our results may help to explain the mechanism underlying the cell fusion event specific for syncytiotrophoblast formation...
  53. pmc Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions
    Beda Joos
    University Hospital Zurich, Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, Ramistrasse 100, CH 8091 Zurich, Switzerland
    J Virol 79:9026-37. 2005
    ....
  54. pmc Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus
    Elena Chertova
    AIDS Vaccine Program, SAIC Frederick, Maryland 21702 1201, USA
    J Virol 76:5315-25. 2002
    ..These findings suggest that incorporation of SU-TM complexes into the viral membrane may be the primary factor determining the quantity of SU associated with SIV and HIV-1 virions, rather than shedding of SU from mature virions...
  55. ncbi Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta
    Alan Smallwood
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London SE5 9RS, United Kingdom
    Biol Reprod 69:286-93. 2003
    ..Therefore, the relative levels of 3.1 kb and 8 kb mRNAs in trophoblasts could regulate syncytin protein synthesis, possibly by competition of the two mRNA species for translational apparatus...
  56. pmc Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages
    Brandon L Walter
    Rocky Mountain Laboratories, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 79:4828-37. 2005
    ..Thus, the limited expression of CD4 on macrophages or other cell types could serve as a selective factor for V1 and V2 envelope sequences, and this selection could in turn influence many aspects of AIDS pathogenesis in vivo...
  57. ncbi Expression cloning of new receptors used by simian and human immunodeficiency viruses
    H K Deng
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Howard Hughes Medical Institute, New York University Medical Center, New York 10016, USA
    Nature 388:296-300. 1997
    ..Usage of these new receptors following experimental infection of non-human primates with SIV strains may provide important insight into viral transmission and the mechanisms of SIV- and HIV-induced acquired immune-deficiency syndrome...
  58. pmc Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses
    Yi Liu
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    Virology 374:229-33. 2008
    ....
  59. ncbi Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication
    Enrique R Argañaraz
    Department of Medicine, School of Medicine, University of California, La Jolla, 92093, USA
    J Biol Chem 278:33912-9. 2003
    ..These strains efficiently overcome the deleterious effects of CD4 and replicate more aggressively in CD4-positive primary lymphocytes. These results highlight the importance of the virus-induced CD4 down-modulation in HIV-1 pathogenesis...
  60. ncbi Selective pressures of human immunodeficiency virus type 1 (HIV-1) during pediatric infection
    Elcio Leal
    Federal University of Sao Paulo, Sao Paulo, Brazil
    Infect Genet Evol 7:694-707. 2007
    ..The second region, restricted to amino acids 334-368 of Gp160, contains sites that might increase viral fitness during interhost transmission at the population level...
  61. pmc Human immunodeficiency virus type 1 Gag contains a dileucine-like motif that regulates association with multivesicular bodies
    O Wolf Lindwasser
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 143, New York, NY 10021, USA
    J Virol 78:6013-23. 2004
    ..We propose that HIV-1 Gag contains a signal that promotes interaction with the cellular endocytic machinery and that the site of particle production is regulated by the subcellular distribution of cholesterol...
  62. ncbi Quantitative analysis of human endogenous retrovirus-W env in neuroinflammatory diseases
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    AIDS Res Hum Retroviruses 22:1253-9. 2006
    ..033 log10/ml versus MS: 2.9 log10/ml). These observations emphasize the selective induction of syncytin-1 in brain tissue of MS patients but also illustrate the complex dynamics of this retroelement in neuroinflammatory processes...
  63. ncbi Structural characterization of the fusion core in syncytin, envelope protein of human endogenous retrovirus family W
    Rui Gong
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
    Biochem Biophys Res Commun 331:1193-200. 2005
    ..The fusion core structure of syncytin was first demonstrated in endogenous retrovirus. These results support the explanation how syncytin mediates cytotrophoblast cell fusion involved in placental morphogenesis...
  64. pmc CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor
    B Crise
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510 8023
    J Virol 64:5585-93. 1990
    ....
  65. ncbi Functional characterization of the placental fusogenic membrane protein syncytin
    Chingwen Chang
    Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan
    Biol Reprod 71:1956-62. 2004
    ..Our results suggest that the cytoplasmic domain of syncytin is not essential for syncytin-mediated fusion but may play a regulatory role, and an intramolecular interaction between HRA and B is involved in the fusion process...
  66. pmc Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA
    Retrovirology 3:73. 2006
    ..We investigated the possible influence of viral genotype and humoral immune response on disease progression in infants...
  67. pmc Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infection
    Daniel Shriner
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    Genetics 166:1155-64. 2004
    ..We conclude that the genetic variation in these data sets can be explained by a predominance of random genetic drift of neutral mutations with brief episodes of natural selection that were frequently masked by recombination...
  68. ncbi An essential role for the His-8 residue of the SDF-1alpha-chimeric, tropism-redirected Env protein of the Moloney murine leukemia virus in regulating postbinding fusion events
    Masumi Katane
    Molecular Cell Science Laboratory, Discovery Research Institute, RIKEN, Wako, Saitama 351 0198, Japan
    J Gene Med 6:260-7. 2004
    ....
  69. pmc Low pH is required for avian sarcoma and leukosis virus Env-induced hemifusion and fusion pore formation but not for pore growth
    G B Melikyan
    Department of Molecular Biophysics and Physiology, Rush Medical College, Chicago, Illinois 60612, USA
    J Virol 78:3753-62. 2004
    ..At this point, but not before, low pH can induce fusion and is in fact required for fusion to occur. However, low pH is no longer necessary after formation of the initial fusion pore: pore enlargement does not require low pH...
  70. pmc HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formation
    Ruben M Markosyan
    Department of Molecular Biophysics and Physiology, Rush Medical College, Chicago, Illinois 60612, USA
    Mol Biol Cell 14:926-38. 2003
    ..It is concluded that an essential function of the bundle is to stabilize the pore against collapse and ensure its growth...
  71. pmc Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus
    Alla Danilkovitch-Miagkova
    Laboratory of Immunobiology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 100:4580-5. 2003
    ..We find activated RON in a subset of human bronchioloalveolar carcinoma tumors, suggesting RON involvement in this type of human lung cancer...
  72. ncbi Structural and immunogenicity analysis of chimeric B-cell epitope constructs derived from the gp46 and gp21 subunits of the envelope glycoproteins of HTLV-1
    R Sundaram
    Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH 43210, USA
    J Pept Res 63:132-40. 2004
    ..The applicability of a chimeric approach is discussed in the context of recent findings regarding the role of gp21 transmembrane region in the viral fusion process...
  73. pmc Determinants of high titer in recombinant porcine endogenous retroviruses
    Ian Harrison
    National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    J Virol 78:13871-9. 2004
    ..Taken together, these results show that the novel juxtaposition of env gene sequences enhanced the infectivity of PERV-A14/220 for human cells, perhaps by stabilization of the envelope glycoprotein or increased receptor binding...
  74. pmc Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
    Rika Draenert
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 203:529-39. 2006
    ..These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape...
  75. ncbi CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues
    Magda Matouskova
    Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo námìstí 2, 16637 Prague 6, Czech Republic
    Exp Cell Res 312:1011-20. 2006
    ....
  76. ncbi Role of HIV-2 envelope in Lv2-mediated restriction
    Sandra Reuter
    Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Virology 332:347-58. 2005
    ..A remaining restriction to infection (19-fold) is preserved when endosomal acidification is prevented. This restriction to infection is also dependent on the presence of the point mutation at position 74 (G74E)...
  77. ncbi Altered placental syncytin and its receptor ASCT2 expression in placental development and pre-eclampsia
    C P Chen
    Division of High Risk Pregnancy, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, and Graduate Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan
    BJOG 113:152-8. 2006
    ..To investigate the alterations of syncytin, a fusogenic membrane protein involved in syncytiotrophoblastic layer formation, and its receptor ASCT2 expression in placental development and pre-eclampsia...
  78. pmc Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4
    R L Willey
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 66:7193-200. 1992
    ....
  79. pmc Use of different but overlapping determinants in a retrovirus receptor accounts for non-reciprocal interference between xenotropic and polytropic murine leukemia viruses
    Neal S Van Hoeven
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Retrovirology 2:76. 2005
    ..NRI also occurs between xenotropic and polytropic MLV. The common receptor, Xpr1, has been identified, but a specific receptor has yet to be described...
  80. pmc Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheep
    Marco Caporale
    Institute of Comparative Medicine, University of Glasgow Veterinary School, 464 Bearsden Road, Glasgow G61 1QH, Scotland
    J Virol 80:8030-7. 2006
    ..These data strongly suggest that the JSRV Env functions as a dominant oncoprotein in the natural immunocompetent host and that JSRV can induce OPA in the absence of viral spread...
  81. ncbi Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1
    J Stitz
    Department of Medical Biotechnology, Paul Ehrlich Institut, Langen, 63225, Germany
    Virology 273:16-20. 2000
    ..Thus, HIV-1(GaLV) and HIV-1(10A1) pseudotype vectors may be useful for efficient gene transfer into a variety of human tissues like primary human hematopoietic cells...
  82. pmc The sequence complementarity between HIV-1 5' splice site SD4 and U1 snRNA determines the steady-state level of an unstable env pre-mRNA
    S Kammler
    , , Germany
    RNA 7:421-34. 2001
    ..This suggests that the GAR sequences may play a role in stabilizing the pre-mRNA by sequestering U1 snRNP to SD4...
  83. pmc Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins
    B Kobe
    St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Proc Natl Acad Sci U S A 96:4319-24. 1999
    ..The structure of gp21 implies that the N-terminal fusion peptide is in close proximity to the C-terminal transmembrane domain and likely represents a postfusion conformation...
  84. pmc Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry
    Z Chen
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 71:2705-14. 1997
    ..These findings indicated that, in addition to CCR5, SIV can use one or more unknown coreceptors that are expressed on human PBMCs and CEMx174 cells...
  85. pmc CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity
    Bridget A Puffer
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:2595-605. 2002
    ..Finally, genetic modification of viral Envs to enhance CD4 independence may also result in improved humoral immune responses...
  86. pmc HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells
    C Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:1178-83. 2000
    ..En-velope treatment of lymphocytes led to the cleavage of FAK in a manner consistent with caspase-mediated cleavage...
  87. ncbi Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
    D Weissman
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 389:981-5. 1997
    ..Alternatively, envelope-mediated CCR5 signal transduction may influence viral-associated cytopathicity or apoptosis...
  88. ncbi Developmental expression of HERV-R (ERV3) and HERV-K in human tissue
    Ann Catrin Andersson
    Department of Pathology, Uppsala University Hospital, Uppsala, Sweden
    Virology 297:220-5. 2002
    ..Pol/Int was not possible to quantitate. It appears that ERV3 is expressed in an organ-specific way during embryogenesis and might suggest a possible role in the development and differentiation of human tissues...
  89. ncbi Prognostic role of syncytin expression in breast cancer
    Lars Inge Larsson
    Department of Anatomy and Cell Biology, IBHV, KVL, Frederiksberg C, Copenhagen, Denmark
    Hum Pathol 38:726-31. 2007
    ..Thus, syncytin expression constitutes a positive prognostic factor in breast cancer--a phenomenon that may be related to the involvement of syncytin in mediating fusions between breast cancer cells and endothelial cells...
  90. ncbi Preclinical evaluation of cellular immune responses elicited by a polyvalent DNA prime/protein boost HIV-1 vaccine
    Anthony D Cristillo
    Advanced BioScience Laboratories, Department of Cell Biology, 5510 Nicholson Lane, Kensington, MD 20895, USA
    Virology 346:151-68. 2006
    ....
  91. ncbi Immunogenicity of attenuated vesicular stomatitis virus vectors expressing HIV type 1 Env and SIV Gag proteins: comparison of intranasal and intramuscular vaccination routes
    Michael A Egan
    Wyeth Vaccines Research, Pearl River, New York 10965, USA
    AIDS Res Hum Retroviruses 20:989-1004. 2004
    ....
  92. pmc The C108g epitope in the V2 domain of gp120 functions as a potent neutralization target when introduced into envelope proteins derived from human immunodeficiency virus type 1 primary isolates
    Abraham Pinter
    Laboratory of Retroviral Biology, Public Health Research Institute, 225 Warren Street, Newark, NJ 07103 3535, USA
    J Virol 79:6909-17. 2005
    ....
  93. pmc Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque
    Philip M McKenna
    Department of Microbiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
    J Virol 78:13455-9. 2004
    ..6P). There was no evidence of CD4(+) T-cell loss, and plasma viremia was controlled to undetectable levels by 6 weeks postchallenge and has remained suppressed out to 22 weeks postchallenge...
  94. ncbi HIV type 1 vaccines for worldwide use: predicting in-clade and cross-clade breadth of immune responses
    Adam C Finnefrock
    Vaccine and Biologics Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    AIDS Res Hum Retroviruses 23:1283-92. 2007
    ..For more diverse proteins, adding a second strain can add a significant increase in breadth, although for three or more strains the intrinsic diversity of the protein leads to diminishing improvement...
  95. ncbi Neutralization and infectivity characteristics of envelope glycoproteins from human immunodeficiency virus type 1 infected donors whose sera exhibit broadly cross-reactive neutralizing activity
    Fatim Cham
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Virology 347:36-51. 2006
    ....
  96. pmc Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody
    Mei Yun Zhang
    Human Immunovirology Group, Laboratory of Experimental and Computational Biology, Center for Cancer Research, National Cancer Institute Frederick, NIH, Frederick, Maryland 21702 1201, USA
    J Virol 78:9233-42. 2004
    ....
  97. ncbi Development of a candidate DNA/MVA HIV-1 subtype C vaccine for India
    Sanjeev Kumar
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India
    Vaccine 24:2585-93. 2006
    ..This is the first reported candidate HIV-1 DNA/MVA vaccine employing the Indian subtype C sequences and constitutes a part of a vaccine scheduled to enter a preclinical non-human primate evaluation in India...
  98. pmc Induction of neutralizing antibodies against human immunodeficiency virus type 1 primary isolates by Gag-Env pseudovirion immunization
    Jason Hammonds
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Virol 79:14804-14. 2005
    ....
  99. pmc Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants
    Y Li
    Vaccine Research Center, National Institutes of Health, 40 Convent Drive, Rm 4512, Bethesda, MD 20892, USA
    J Virol 80:1414-26. 2006
    ..Further mapping analysis of more conserved regions of gp120/gp41 may be required to determine the neutralizing specificity elicited by the trimeric immunogens...
  100. pmc Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies
    Ming Li
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Virol 79:10108-25. 2005
    ..These reference reagents will facilitate proficiency testing and other validation efforts aimed at improving assay performance across laboratories and can be used for standardized assessments of vaccine-elicited neutralizing antibodies...
  101. doi Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant
    Yaoxing Huang
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Acquir Immune Defic Syndr 47:403-11. 2008
    ..A phase 1 clinical trial of this product has been successfully completed, and its use in prime-boost studies is now underway...

Research Grants73

  1. Hemorrhagic Fever
    Christopher Broder; Fiscal Year: 2003
    ..Both of these research goals are priorities as immediate and long-term objectives for biodefense research on viral hemorrhagic fevers and emerging viruses. ..
  2. High Mannose Type Carbohydrate-based HIV/AIDS Vaccine
    Yu Geng; Fiscal Year: 2009
    ..If success, this novel formulation of immunogen from yeast mutant strain will be a safe, cheap, and effective HIV/AIDS vaccine against a broad range of HIV-1 primary isolates. ..
  3. MUCOSAL IMMUNITY TO HIV ENV BY ORAL VACCINATION
    Danuta Kozbor; Fiscal Year: 2001
    ..vaccination with plasmid DNA encoding gp160 in combination with recombinant viral vectors expressing the env gene products to enhance the antigen-specific mucosal and systemic immunity...
  4. MUCOSAL IMMUNITY TO HIV ENV BY ORAL VACCINATION
    Danuta Kozbor; Fiscal Year: 2001
    ..vaccination with plasmid DNA encoding gp160 in combination with recombinant viral vectors expressing the env gene products to enhance the antigen-specific mucosal and systemic immunity...
  5. MUCOSAL IMMUNITY TO HIV ENV BY ORAL VACCINATION
    Danuta Kozbor; Fiscal Year: 2000
    ..vaccination with plasmid DNA encoding gp160 in combination with recombinant viral vectors expressing the env gene products to enhance the antigen-specific mucosal and systemic immunity...
  6. Nipah Virus Pathobiology and Effects on Innate Immunity
    Linda Baum; Fiscal Year: 2009
    ..The co-investigators have a unique combination of expertise, and propose an innovative set of studies into the glycobiology of NiV pathogenesis. ..
  7. Nipah Virus Pathobiology and Effects on Innate Immunity
    Linda Baum; Fiscal Year: 2005
    ..The co-investigators have a unique combination of expertise, and propose an innovative set of studies into the glycobiology of NiV pathogenesis. ..
  8. Nipah Virus Pathobiology and Effects on Innate Immunity
    Linda Baum; Fiscal Year: 2006
    ..The co-investigators have a unique combination of expertise, and propose an innovative set of studies into the glycobiology of NiV pathogenesis. ..
  9. Nipah Virus Pathobiology and Effects on Innate Immunity
    Linda Baum; Fiscal Year: 2007
    ..The co-investigators have a unique combination of expertise, and propose an innovative set of studies into the glycobiology of NiV pathogenesis. ..
  10. Structure and Immunogenicity of Cleaved, Stabilized HIV-1 Envelope Trimers
    William Olson; Fiscal Year: 2009
    ..The overall outcome of these various studies will help design additional Env sequence modifications in Aim 1 that are intended to further improve immunogenicity or eliminate the causes of immunosuppression. ..
  11. Single-particle Reconstruction of HIV-1 Envelope Glycoprotein Trimers
    Joseph G Sodroski; Fiscal Year: 2011
    ..We will develop methods in electron microscopy that allow a detailed structural blueprint of the HIV-1 envelope glycoprotein spike to be realized. ..
  12. GENETIC DIVERSITY OF SIMIAN RETROVIRUSES
    CURTIS MACHIDA; Fiscal Year: 2000
    ..Yeast two-hybrid system identification of molecules interacting with simian retroviral env gene products. In Program of the Sixteen Annual Symposium on Nonhuman Primate Models for AIDS (held in Atlanta, GA, ..
  13. Induction of neutralizing antibodies targeting CD4 binding region of HIV-1 Env
    Shan Lu; Fiscal Year: 2009
    ....
  14. HIV-1 ENV PROTEINS--TARGETS FOR ANTIVIRAL CHEMOTHERAPY
    A Robert Neurath; Fiscal Year: 1993
    ..Accomplishment of these goals is expected to lead to improved combined therapy, and possibly prophylaxis of HIV-1 infections...
  15. Interferon inducing Newcastle disease viruses as HIV-1 vaccines
    Adolfo Garcia Sastre; Fiscal Year: 2009
    ..Our studies will unravel several of these properties and at the same time, will develop improved NDV-HIV vectors as potential novel immunogens to be used in HIV vaccine approaches. ..
  16. STRUCTURE/FUNCTION ANALYSIS OF THE HIV ENV GENE PRODUCT
    Eric Hunter; Fiscal Year: 2003
    ....
  17. STRUCTURE/FUNCTION ANALYSIS OF THE HIV ENV GENE PRODUCT
    Eric Hunter; Fiscal Year: 2001
    ....
  18. STRUCTURE/FUNCTION ANALYSIS OF THE HIV ENV GENE PRODUCT
    Eric Hunter; Fiscal Year: 2002
    ....
  19. THE ENVELOPE GENE PRODUCTS OF MURINE LEUKEMIA VIRUS
    MONICA ROTH; Fiscal Year: 1991
    ..The viral gene products which are known to be required for the entry of the virus into the cells (env gene products) will be studied genetically and biochemically...
  20. THE ENVELOPE GENE PRODUCTS OF MURINE LEUKEMIA VIRUS
    MONICA ROTH; Fiscal Year: 1990
    ..The viral gene products which are known to be required for the entry of the virus into the cells (env gene products) will be studied genetically and biochemically...
  21. ENVELOPE GENE PRODUCTS OF MURINE LEUKEMIA VIRUS 0
    MONICA ROTH; Fiscal Year: 1992
    ..The viral gene products which are known to be required for the entry of the virus into the cells (env gene products) will be studied genetically and biochemically...
  22. THE ENVELOPE GENE PRODUCTS OF MURINE LEUKEMIA VIRUS
    MONICA ROTH; Fiscal Year: 1993
    ..The viral gene products which are known to be required for the entry of the virus into the cells (env gene products) will be studied genetically and biochemically...
  23. INFLUENCE OF MULV ENV AND GAG GENES IN LEUKEMOGENESIS
    NANCY FAMULARI; Fiscal Year: 1980
    ..A correlation will be sought between specific aspects of the synthesis and processing of env gene products and the ability of AKR dualtropic MCF viruses to induce preleukemic changes and leukemia development in AKR ..
  24. NCI OUTSTANDING INVESTIGATOR GRANT
    Myron Essex; Fiscal Year: 1990
    ..let to identification of an HTLV agent as the apparent cause of AIDS, the first identification of the HTLV env gene products, the first demonstration of the pX putative transforming protein(s) of HTLV, and the link between HTLV-like ..
  25. HIV-1 gp140 Oligomers as Vaccine Immunogens
    Christopher Broder; Fiscal Year: 2001
    ..abstract_text> ..
  26. LEUKEMOGENIC RETROVIRAL GLYCOPROTEIN: GP55-GP70S
    David Kabat; Fiscal Year: 1993
    ..The murine model has unique experimental advantages...
  27. LEUKEMOGENIC RETROVIRAL GLYCOPROTEIN--GP55-GP70S
    David Kabat; Fiscal Year: 1992
    ..The murine model has unique experimental advantages...
  28. HIV-1 gp140 Oligomers as Vaccine Immunogens
    Christopher Broder; Fiscal Year: 2002
    ..abstract_text> ..
  29. Intersubtype recombinants for polyvalent anti-HIV vaccine
    Yong Gao; Fiscal Year: 2009
    ....
  30. Mechanism of p12I and p30II in HTLV1 Infection
    Michael Lairmore; Fiscal Year: 2002
    ..This complex retrovirus encodes typical gag, pol, and env gene products, as well as unique regulatory and accessory genes encoded in pX ORF I-IV between the env gene and the 3' LTR...
  31. Mechanism of p12I and p30II in HTLV1 Infection
    Michael Lairmore; Fiscal Year: 2003
    ..This complex retrovirus encodes typical gag, pol, and env gene products, as well as unique regulatory and accessory genes encoded in pX ORF I-IV between the env gene and the 3' LTR...
  32. Intersubtype recombinants for polyvalent anti-HIV vaccine
    Yong Gao; Fiscal Year: 2010
    ....
  33. Novel HIV-1 vaccine candidates using newly transmitted clade C Envs as immunogens
    Jerry Blackwell; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2000
    ..Understanding this process in detail should lead to better antiviral therapeutic strategies and aid with viral targeting approaches for gene therapy protocols. ..
  35. Multi-component HIV Vaccines Using Engineered Envelopes
    Susan Barnett; Fiscal Year: 2003
    ..These efforts are expected to lead to the selection of a strong candidate vaccine regimen for future clinical evaluations. ..
  36. VIRAL AND MOUSE GENES IN LEUKEMIA VIRUS INFECTION
    ERWIN FLEISSNER; Fiscal Year: 1980
    ..The structures of the viral env gene products produced in fibroblasts will be compared in tests with monoclonal antibodies and by sensitive peptide ..
  37. Multi-component HIV Vaccines Using Engineered Envelopes
    Susan Barnett; Fiscal Year: 2002
    ..These efforts are expected to lead to the selection of a strong candidate vaccine regimen for future clinical evaluations. ..
  38. DNA Vaccines With HIV Virus-like Particles
    Ted Ross; Fiscal Year: 2003
    ..elicit both humoral and cell-mediated immune responses to the major structural proteins of HIV, the Gag and Env gene products. The VLP has safety mutations designed into vaccine in order to meet U.S...
  39. DNA Vaccines With HIV Virus-like Particles
    Ted Ross; Fiscal Year: 2002
    ..elicit both humoral and cell-mediated immune responses to the major structural proteins of HIV, the Gag and Env gene products. The VLP has safety mutations designed into vaccine in order to meet U.S...
  40. DNA Vaccines With HIV Virus-like Particles
    Ted Ross; Fiscal Year: 2003
    ..elicit both humoral and cell-mediated immune responses to the major structural proteins of HIV, the Gag and Env gene products. The VLP has safety mutations designed into vaccine in order to meet U.S...
  41. Optimization of HIV vaccines for the induction of cross-reactive antibodies
    Shan Lu; Fiscal Year: 2009
    ..RELEVANCE: To optimize the next generation polyvalent Env HIV vaccine formulations using the multi-gene, polyvalent DNA prime - protein boost technology platform. ..
  42. Optimization of HIV vaccines for the induction of cross-reactive antibodies
    Shan Lu; Fiscal Year: 2010
    ..RELEVANCE: To optimize the next generation polyvalent Env HIV vaccine formulations using the multi-gene, polyvalent DNA prime - protein boost technology platform. ..
  43. HIV-1 DNA VACCINES THAT TARGET AND ACTIVATE CD40
    JEFFREY LEDBETTER; Fiscal Year: 2000
    ..Antibody responses towards HIV-1 env will be tested by epitope specific ELISA assays and viral neutralization assays. ..
  44. HIV-1 DNA VACCINES THAT TARGET AND ACTIVATE CD40
    JEFFREY LEDBETTER; Fiscal Year: 2001
    ..Antibody responses towards HIV-1 env will be tested by epitope specific ELISA assays and viral neutralization assays. ..
  45. ALTERATIONS OF ION TRANSPORT BY HIV
    Robert Garry; Fiscal Year: 2000
    ..The env gene products, SU (gpl20) and TM (gp4l) have been implicated in HIV cytopathogenesis...
  46. ALTERATIONS OF ION TRANSPORT BY HIV
    Robert Garry; Fiscal Year: 1999
    ..The env gene products, SU (gpl20) and TM (gp4l) have been implicated in HIV cytopathogenesis...
  47. Endogenous retroviruses and gene regulation after injury
    Kiho Cho; Fiscal Year: 2010
    ..Furthermore, the findings from this study may lead to a further investigation into the development of a novel therapeutic protocol for burn patients in combination with current regimens. ..
  48. P12 AND P30 IN HTLV REPLICATION AND LYMPHOCYTE ACTIVATIO
    Michael Lairmore; Fiscal Year: 2003
    ..This complex retrovirus encodes typical gag, pol and env gene products as well as unique regulatory and accessory genes encoded in pX ORF I-IV between the env gene and the 3' LTR...
  49. Endogenous retroviruses and gene regulation after injury
    Kiho Cho; Fiscal Year: 2009
    ..Furthermore, the findings from this study may lead to a further investigation into the development of a novel therapeutic protocol for burn patients in combination with current regimens. ..
  50. GLYCOSYLATION OF SIV GP120--ROLE IN THE IMMUNE RESPONSE
    NORMAN SALZMAN; Fiscal Year: 1990
    ..persons show humoral and cell-mediated immune responses to HIv antigens and in particular to the env gene products of HIV, the external envelope glycoprotein gp120 (EEG)...
  51. LEUKEMOGENIC MEMBRANE GLYCOPROTEINS: GP55S OF SFFVS
    David Kabat; Fiscal Year: 1990
    ..forming virus (SFFV) encodes a membranes glycoprotein (gp55) which is structurally related to the larger env gene products of recombinant-type dualtropic MCF viruses, that gp55 causes mitosis of infected erythroblasts, and that the ..
  52. LEUKEMOGENIC MEMBRANE GLYCOPROTEINS: GP55S OF SFFVS
    David Kabat; Fiscal Year: 1991
    ..forming virus (SFFV) encodes a membranes glycoprotein (gp55) which is structurally related to the larger env gene products of recombinant-type dualtropic MCF viruses, that gp55 causes mitosis of infected erythroblasts, and that the ..
  53. Enhancement of virus-like particle immunogenicity
    Richard Compans; Fiscal Year: 2003
    ..Further, we will interact and collaborate with investigators in the other projects to develop improved VLP formulations to be evaluated in animal models, and considered for advancement to human trials. ..
  54. HIV-1 Env Vaccine Design
    John Moore; Fiscal Year: 2009
    ..This HIVRAD represents an innovative approach to addressing these challenges in order to provide a fundamental advance in our ability to elicit HFV-neutralizingantibodies with a vaccine. ..
  55. Multi-component HIV Vaccines Using Engineered Envelopes
    Susan Barnett; Fiscal Year: 2004
    ..These efforts are expected to lead to the selection of a strong candidate vaccine regimen for future clinical evaluations. ..
  56. Studies of p30 II and p13 II in HTLV-1 Infection
    Michael Lairmore; Fiscal Year: 2002
    ..This complex retrovirus encodes typical gag, pol, and env gene products, as well as unique regulatory and accessory genes encoded in pX ORF I-IV...
  57. Novel Chimeric Env Glycoproteins for AIDS Vaccines
    Ling Ye; Fiscal Year: 2004
    ..We will also test the effectiveness of different priming-boosting protocols in eliciting cross-reactive neutralizing antibodies against HIV. ..
  58. Development of Novel Immunogens for Vaccines to HIV-1
    ROBERT GERALD WHALEN; Fiscal Year: 2009
    ..In a third aim, various formats of Env will be tested to determine which one is optimal for presenting the most immunogenic Env sequences. Virus-like particles in which the Env complex is stabilized will be targeted. ..
  59. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2002
    ..Understanding this process in detail should lead to better antiviral therapeutic strategies and aid with viral targeting approaches for gene therapy protocols. ..
  60. Studies of p30 II and p13 II in HTLV-1 Infection
    Michael Lairmore; Fiscal Year: 2003
    ..This complex retrovirus encodes typical gag, pol, and env gene products, as well as unique regulatory and accessory genes encoded in pX ORF I-IV...
  61. Development of Novel Immunogens for Vaccines to HIV-1
    Robert Whalen; Fiscal Year: 2009
    ..In a third aim, various formats of Env will be tested to determine which one is optimal for presenting the most immunogenic Env sequences. Virus-like particles in which the Env complex is stabilized will be targeted. ..
  62. Development of Novel Immunogens for Vaccines to HIV-1
    Robert Whalen; Fiscal Year: 2005
    ..In a third aim, various formats of Env will be tested to determine which one is optimal for presenting the most immunogenic Env sequences. Virus-like particles in which the Env complex is stabilized will be targeted. ..
  63. Development of Novel Immunogens for Vaccines to HIV-1
    Robert Whalen; Fiscal Year: 2005
    ..This Project will contribute to the overall goals of the HIVRAD Program in developing approaches to increase the immunogenicity of HIV antigens. ..
  64. Development of Novel Immunogens for Vaccines to HIV-1
    Robert Whalen; Fiscal Year: 2006
    ..In a third aim, various formats of Env will be tested to determine which one is optimal for presenting the most immunogenic Env sequences. Virus-like particles in which the Env complex is stabilized will be targeted. ..
  65. Development of Novel Immunogens for Vaccines to HIV-1
    Robert Whalen; Fiscal Year: 2007
    ..In a third aim, various formats of Env will be tested to determine which one is optimal for presenting the most immunogenic Env sequences. Virus-like particles in which the Env complex is stabilized will be targeted. ..
  66. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2004
    ..Understanding this process in detail should lead to better antiviral therapeutic strategies and aid with viral targeting approaches for gene therapy protocols. ..
  67. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2001
    ..Understanding this process in detail should lead to better antiviral therapeutic strategies and aid with viral targeting approaches for gene therapy protocols. ..
  68. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2003
    ..Understanding this process in detail should lead to better antiviral therapeutic strategies and aid with viral targeting approaches for gene therapy protocols. ..
  69. Studies of p30 II and p13 II in HTLV-1 Infection
    Michael Lairmore; Fiscal Year: 2004
    ..This complex retrovirus encodes typical gag, pol, and env gene products, as well as unique regulatory and accessory genes encoded in pX ORF I-IV...
  70. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2003
    ..Understanding this process in detail should lead to better antiviral therapeutic strategies and aid with viral targeting approaches for gene therapy protocols. ..
  71. Creation of Stable Cleaved Trimers of the HIV-1 Envelope Protein
    Robert Whalen; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..