env gene products

Summary

Summary: Retroviral proteins, often glycosylated, coded by the envelope (env) gene. They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease.

Top Publications

  1. ncbi Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
    S Mi
    Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
    Nature 403:785-9. 2000
  2. ncbi Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 7:1088-95. 2004
  3. pmc Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation
    Jean Louis Frendo
    Unité INSERM 427, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, 75006 Paris, France
    Mol Cell Biol 23:3566-74. 2003
  4. ncbi Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen
    N Sutkowski
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    Immunity 15:579-89. 2001
  5. ncbi Expression of HERV-W Env glycoprotein (syncytin) in the extravillous trophoblast of first trimester human placenta
    A Malassine
    INSERM U427, Faculte des Sciences Pharmaceutiques et Biologiques, Université Renée Descartes, France
    Placenta 26:556-62. 2005
  6. pmc Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease
    S R Broussard
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    J Virol 75:2262-75. 2001
  7. pmc Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins
    C Berlioz-Torrent
    CJF 97 03 INSERM, Interactions Moléculaires, Hôte Pathogène, Institut Cochin de Genetique Moleculaire, 75014 Paris, France
    J Virol 73:1350-61. 1999
  8. ncbi Mechanisms of viral membrane fusion and its inhibition
    D M Eckert
    Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, M I T, Cambridge, Massachusetts 02142, USA
    Annu Rev Biochem 70:777-810. 2001
  9. ncbi Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity
    Y Stauffer
    Department of Genetics and Microbiology, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Immunity 15:591-601. 2001
  10. ncbi Determinants of foamy virus envelope glycoprotein mediated resistance to superinfection
    Angelika Berg
    Institut fur Virologie und Immunbiologie, Universitat Wurzburg, 97078 Wurzburg, Germany
    Virology 314:243-52. 2003

Detail Information

Publications240 found, 100 shown here

  1. ncbi Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
    S Mi
    Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
    Nature 403:785-9. 2000
    ..Our data indicate that syncytin may mediate placental cytotrophoblast fusion in vivo, and thus may be important in human placental morphogenesis...
  2. ncbi Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 7:1088-95. 2004
    ..Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention...
  3. pmc Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation
    Jean Louis Frendo
    Unité INSERM 427, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, 75006 Paris, France
    Mol Cell Biol 23:3566-74. 2003
    ..Taken together, these results strongly support a direct role for Env-W in human trophoblast cell fusion and differentiation...
  4. ncbi Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen
    N Sutkowski
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    Immunity 15:579-89. 2001
    ..The T cell activation elicited by the Sag could play a central role in EBV infection and associated diseases...
  5. ncbi Expression of HERV-W Env glycoprotein (syncytin) in the extravillous trophoblast of first trimester human placenta
    A Malassine
    INSERM U427, Faculte des Sciences Pharmaceutiques et Biologiques, Université Renée Descartes, France
    Placenta 26:556-62. 2005
    ..HERV-W Env glycoprotein expressed in villous and extravillous trophoblast can be considered as a specific marker of the human trophoblast...
  6. pmc Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease
    S R Broussard
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    J Virol 75:2262-75. 2001
    ....
  7. pmc Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins
    C Berlioz-Torrent
    CJF 97 03 INSERM, Interactions Moléculaires, Hôte Pathogène, Institut Cochin de Genetique Moleculaire, 75014 Paris, France
    J Virol 73:1350-61. 1999
    ....
  8. ncbi Mechanisms of viral membrane fusion and its inhibition
    D M Eckert
    Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, M I T, Cambridge, Massachusetts 02142, USA
    Annu Rev Biochem 70:777-810. 2001
    ..This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible...
  9. ncbi Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity
    Y Stauffer
    Department of Genetics and Microbiology, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Immunity 15:591-601. 2001
    ..Endogenous SAgs induced via IFN-alpha by viral infections is a novel mechanism through which environmental factors may cause disease in genetically susceptible individuals...
  10. ncbi Determinants of foamy virus envelope glycoprotein mediated resistance to superinfection
    Angelika Berg
    Institut fur Virologie und Immunbiologie, Universitat Wurzburg, 97078 Wurzburg, Germany
    Virology 314:243-52. 2003
    ..This implies that all of them use the same receptor molecules for viral entry...
  11. ncbi Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication
    Enrique R Argañaraz
    Department of Medicine, School of Medicine, University of California, La Jolla, 92093, USA
    J Biol Chem 278:33912-9. 2003
    ..These strains efficiently overcome the deleterious effects of CD4 and replicate more aggressively in CD4-positive primary lymphocytes. These results highlight the importance of the virus-induced CD4 down-modulation in HIV-1 pathogenesis...
  12. ncbi The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses
    Alexandre Rolland
    Laboratoire d Immunochimie, Institut National de la Santé et de la Recherche Médicale Unité 548, Commissariat a l Energie Atomique, Grenoble, France
    J Immunol 176:7636-44. 2006
    ..Finally, ENV-SU endowed dendritic cells with the capacity to support a Th1-like type of Th cell differentiation. The data are discussed in the context of immune responses and chronic proinflammatory disorders...
  13. ncbi The M-PMV cytoplasmic targeting-retention signal directs nascent Gag polypeptides to a pericentriolar region of the cell
    Jeffrey N Sfakianos
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Traffic 4:660-70. 2003
    ..Thus the previously defined cytoplasmic targeting-retention signal appears to act as a cotranslational intracellular targeting signal that concentrates Gag proteins at the centriole for assembly of capsids...
  14. ncbi Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action
    A J G Pötgens
    Department of Anatomy II, University Hospital Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Hum Reprod Update 10:487-96. 2004
    ..In some of the hypotheses proposed, local coexpression of syncytin and receptor, leading to blocking of one factor by the other, is of functional relevance...
  15. pmc Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins
    Marianne Mangeney
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, F 94805 Villejuif, France
    Proc Natl Acad Sci U S A 104:20534-9. 2007
    ..Selective inactivation of immunosuppression, under conditions not affecting fusogenicity, should be important for understanding the role of this function in placental physiology and maternofetal tolerance...
  16. ncbi Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells
    A Malassine
    INSERM, U767, 4 avenue de l Observatoire, 75006 Paris, France Université Paris Descartes, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, 75006 Paris, France
    Placenta 28:185-91. 2007
    ..In vitro detection of HERV-FRD transcripts was restricted to villous trophoblastic cells and decreased significantly with time in culture. These results suggest that syncytin 2 might play a role in human trophoblastic cell fusion...
  17. pmc Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins
    Shan Lu Liu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 77:2850-8. 2003
    ....
  18. ncbi Identification of a major co-receptor for primary isolates of HIV-1
    H Deng
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
    Nature 381:661-6. 1996
    ..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta...
  19. pmc Transactivation of elements in the human endogenous retrovirus W family by viral infection
    Christoffer Nellåker
    The Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Retrovirology 3:44. 2006
    ....
  20. pmc Sheep retrovirus structural protein induces lung tumours
    Sarah K Wootton
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nature 434:904-7. 2005
    ....
  21. ncbi M-PMV capsid transport is mediated by Env/Gag interactions at the pericentriolar recycling endosome
    Jeffrey N Sfakianos
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Traffic 4:671-80. 2003
    ..Thus, for the first time, endocytic trafficking of a retroviral Env glycoprotein is linked to the efficient cytoplasmic transport of Gag...
  22. pmc Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus
    Rika Draenert
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 203:529-39. 2006
    ..These results reveal considerable concordance of adaptive cellular and humoral immune responses and HIV evolution in the same genetic environment, suggesting constraints on mutational pathways to HIV immune escape...
  23. pmc Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection
    Simon D W Frost
    Department of Pathology, University of California at San Diego, La Jolla, CA 92093 0679, USA
    Proc Natl Acad Sci U S A 102:18514-9. 2005
    ..Our results suggest that autologous neutralizing antibody responses may play a pivotal role in the diversification of HIV-1 envelope during the early stages of infection...
  24. ncbi Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions
    Hervé Perron
    bioMerieux, R and D, Chemin de l orme, 69280 Marcy l Etoile, France
    J Neurovirol 11:23-33. 2005
    ..This is compatible with a pathophysiological role in MS, but also illustrates the ambivalence of such HERV antigens, which can be expressed in cell-specific patterns, under physiological or pathological conditions...
  25. pmc Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope
    V Cheynet
    Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, INSERM U412, Ecole Normale Superieure de Lyon, 69364 Lyon, France
    J Virol 79:5585-93. 2005
    ..These SU and TM subunits are found associated as homotrimers. The intracytoplasmic tail is critical to the fusogenic phenotype, although its cleavage requirements seem to have diverged from those of classical retroviral maturation...
  26. ncbi Recombination: Multiply infected spleen cells in HIV patients
    Andreas Jung
    Department of Virology, University of the Saarland, 66421 Homburg, Germany
    Nature 418:144. 2002
    ..Although this creates problems for phylogenetic analyses, which ignore recombination effects, the intracellular variation may help to broaden immune recognition...
  27. ncbi Structural characterization of the fusion core in syncytin, envelope protein of human endogenous retrovirus family W
    Rui Gong
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
    Biochem Biophys Res Commun 331:1193-200. 2005
    ..The fusion core structure of syncytin was first demonstrated in endogenous retrovirus. These results support the explanation how syncytin mediates cytotrophoblast cell fusion involved in placental morphogenesis...
  28. pmc CD4-induced T-20 binding to human immunodeficiency virus type 1 gp120 blocks interaction with the CXCR4 coreceptor
    Wen Yuan
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Virol 78:5448-57. 2004
    ..Interactions between the gp41 HR2 region and coreceptor-binding regions of gp120 may also play a role in the function of the HIV-1 envelope glycoproteins...
  29. ncbi Expression of the human endogenous retrovirus-K transmembrane envelope, Rec and Np9 proteins in melanomas and melanoma cell lines
    Kristina Büscher
    Robert Koch Institute, Berlin, Germany
    Melanoma Res 16:223-34. 2006
    ..Additional experiments are needed to determine their involvement, if any, in cell proliferation and tumor progression...
  30. ncbi The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Immunol 179:1210-24. 2007
    ..These studies provide new insights into the role of HERV-mediated neuroinflammation and its contribution to an autoimmune disease...
  31. pmc Diversity of the human immunodeficiency virus type 1 (HIV-1) env sequence after vertical transmission in mother-child pairs infected with HIV-1 subtype A
    Chris Verhofstede
    AIDS Reference Laboratory, Ghent University Hospital, Ghent, Belgium
    J Virol 77:3050-7. 2003
    ..Phylogenetic tree topologies argue against selection processes as the major mechanism driving mother-to-child transmission but support the hypothesis that virus variability is mainly driven by the inoculum level and/or exposure time...
  32. pmc Wild-type-like viral replication potential of human immunodeficiency virus type 1 envelope mutants lacking palmitoylation signals
    Woan Eng Chan
    Institute of Biomedical Sciences, Academia Sinica, 128 Yen Chiu Yuan Road, Section 2, Nankang, Taipei 11529, Taiwan, Republic of China
    J Virol 79:8374-87. 2005
    ..Our results together support the notion that palmitoylation of the cytoplasmic tail of the HIV-1 Env is not essential for the HIV-1 virus life cycle...
  33. pmc CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor
    B Crise
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510 8023
    J Virol 64:5585-93. 1990
    ....
  34. pmc Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheep
    Marco Caporale
    Institute of Comparative Medicine, University of Glasgow Veterinary School, 464 Bearsden Road, Glasgow G61 1QH, Scotland
    J Virol 80:8030-7. 2006
    ..These data strongly suggest that the JSRV Env functions as a dominant oncoprotein in the natural immunocompetent host and that JSRV can induce OPA in the absence of viral spread...
  35. ncbi Syncytin, a novel human endogenous retroviral gene in human placenta: evidence for its dysregulation in preeclampsia and HELLP syndrome
    Ina Knerr
    Department of Pediatrics, University of Erlangen Nuremberg, Germany
    Am J Obstet Gynecol 186:210-3. 2002
    ..We tested the hypothesis of whether the gene expression of syncytin may be altered in cases with placental dysfunction such as preeclampsia or HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome...
  36. ncbi An inducible HIV type 1 gp41 HR-2 peptide-binding site on HIV type 1 envelope gp120
    S Munir Alam
    Department of Medicine, Duke Center for AIDS Research, Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina 27707, USA
    AIDS Res Hum Retroviruses 20:836-45. 2004
    ..This may prove to be an important consideration when designing an HIV vaccine that utilizes constrained HIV Env proteins...
  37. pmc Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection
    M R Betts
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Virol 75:11983-91. 2001
    ..These results suggest that overall frequencies of HIV-specific T cells are not the sole determinant of immune-mediated protection in HIV-infection...
  38. pmc Intracellular trafficking of Gag and Env proteins and their interactions modulate pseudotyping of retroviruses
    Virginie Sandrin
    Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, INSERM U412, IFR128 Biosciences Lyon Gerland, Ecole Normal Supérieure de Lyon, France
    J Virol 78:7153-64. 2004
    ..Thus, intracellular colocalization, as well as interactions between Env and core proteins, may influence the recruitment of the glycoprotein onto viral particles and generate infectious pseudotyped viruses...
  39. ncbi Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues--evidence for a function for envelope gene products
    E Larsson
    Department of Pathology, Uppsala University Hospital, Sweden
    Ups J Med Sci 99:113-20. 1994
    ....
  40. pmc Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus
    A D Miller
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    J Virol 65:2220-4. 1991
    ..These simian virus-based packaging cells extend the host range of currently available murine and avian packaging cells and should be useful for efficient gene transfer into higher mammals...
  41. pmc Human immunodeficiency virus type 1 Env with an intersubunit disulfide bond engages coreceptors but requires bond reduction after engagement to induce fusion
    L G Abrahamyan
    Department of Molecular Biophysics and Physiology, Rush Medical College, Chicago, Illinois 60612, USA
    J Virol 77:5829-36. 2003
    ..The capture of this configuration of Env could yield a suitable antigen for vaccine development, and it may also be a target for pharmacological intervention against HIV-1 entry...
  42. ncbi An env-like protein encoded by a Drosophila retroelement: evidence that gypsy is an infectious retrovirus
    S U Song
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    Genes Dev 8:2046-57. 1994
    ..Thus, gypsy has the expected properties of an insect retrovirus...
  43. ncbi Expression cloning of new receptors used by simian and human immunodeficiency viruses
    H K Deng
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Howard Hughes Medical Institute, New York University Medical Center, New York 10016, USA
    Nature 388:296-300. 1997
    ..Usage of these new receptors following experimental infection of non-human primates with SIV strains may provide important insight into viral transmission and the mechanisms of SIV- and HIV-induced acquired immune-deficiency syndrome...
  44. ncbi HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    T Dragic
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA
    Nature 381:667-73. 1996
    ..CC-CKR-5 is a second receptor for NSI primary viruses...
  45. pmc Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5
    C B Davis
    Division of Molecular Pathogenesis, Skirball Institute for Biomolecular Medicine, NYU Medical Center 10016, USA
    J Exp Med 186:1793-8. 1997
    ..The results presented here provide the first evidence for activation of an intracellular signaling event that can initiate multiple signaling pathways as a consequence of contact between HIV-1 and chemokine receptors...
  46. pmc Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance
    Xiaobin Lu
    VIRxSYS Corporation, Gaithersburg, MD 20877, USA
    J Virol 78:7079-88. 2004
    ..These clones were not found to be escape mutants, as their replicative ability was severely attenuated, and they did not replicate in the presence of vector...
  47. pmc Expression and characterization of a soluble, active form of the jaagsiekte sheep retrovirus receptor, Hyal2
    Vladimir Vigdorovich
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 79:79-86. 2005
    ..In contrast to results obtained with avian retroviruses, purified receptor was not capable of promoting transduction of cells that do not express the virus receptor...
  48. pmc Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1
    Bing Li
    Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
    J Virol 80:5211-8. 2006
    ....
  49. pmc Functional characterization of two newly identified Human Endogenous Retrovirus coding envelope genes
    Sandra Blaise
    Unité de Biologie des Rétrovirus, Departement de Virologie, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Retrovirology 2:19. 2005
    ..Altogether, these results suggest that at least one of these env genes may play a role in placentation, but most probably through a process different from that of the two previously identified syncytins...
  50. pmc The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells
    S Hallenberger
    Institut fur Virologie, Philipps Universitat Marburg, Germany
    J Virol 71:1036-45. 1997
    ..In conclusion, among the known members of the subtilisin family, only furin and LPC/PC7 fulfill the requirements of a protease responsible for in vivo activation of HIV envelope glycoproteins...
  51. ncbi Inhibition of infectious murine leukemia virus production by Fv-4 env gene products exerting dominant negative effect on viral envelope glycoprotein
    Akiko Takeda
    International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Microbes Infect 9:1590-6. 2007
    ....
  52. ncbi Functional characterization of the placental fusogenic membrane protein syncytin
    Chingwen Chang
    Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan
    Biol Reprod 71:1956-62. 2004
    ..Our results suggest that the cytoplasmic domain of syncytin is not essential for syncytin-mediated fusion but may play a regulatory role, and an intramolecular interaction between HRA and B is involved in the fusion process...
  53. pmc Low pH is required for avian sarcoma and leukosis virus Env-induced hemifusion and fusion pore formation but not for pore growth
    G B Melikyan
    Department of Molecular Biophysics and Physiology, Rush Medical College, Chicago, Illinois 60612, USA
    J Virol 78:3753-62. 2004
    ..At this point, but not before, low pH can induce fusion and is in fact required for fusion to occur. However, low pH is no longer necessary after formation of the initial fusion pore: pore enlargement does not require low pH...
  54. ncbi Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
    T M Ross
    Yerkes Regional Primate Research Center, Division of Microbiology and Immunology, Emory University, Atlanta, Georgia 30329, USA
    Curr Biol 9:613-21. 1999
    ..The biological purpose of this internalization has, however, remained unclear...
  55. pmc Invertebrate retroviruses: ZAM a new candidate in D.melanogaster
    P Leblanc
    Unité INSERM U384, Faculte de Medecine, Place Henri Dunant, 63000 Clermont Ferrand, France
    EMBO J 16:7521-31. 1997
    ..This high copy number is associated with a high transcriptional rate of ZAM. The existence of these two categories of strains offers a new genetic system in which the properties of a potential invertebrate retrovirus can be tested...
  56. pmc Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus
    Alla Danilkovitch-Miagkova
    Laboratory of Immunobiology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 100:4580-5. 2003
    ..We find activated RON in a subset of human bronchioloalveolar carcinoma tumors, suggesting RON involvement in this type of human lung cancer...
  57. ncbi Simian immunodeficiency viruses (SIVs) from eastern and southern Africa: detection of a SIVagm variant from a chacma baboon
    E J Van Rensburg
    Department of Medical Virology, University of Stellenbosch and Tygerberg Hospital, South Africa
    J Gen Virol 79:1809-14. 1998
    ..Phylogenetic analysis of the env region showed the virus to be closely related to the South African vervet SIV strains, while analysis of its pol region confirmed the virus to be a SIVagm variant...
  58. ncbi The structural biology of type I viral membrane fusion
    Peter M Colman
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Mol Cell Biol 4:309-19. 2003
    ..Here, we review our understanding of the structural transitions that are involved in this fusion pathway, compare it to our understanding of influenza virus membrane fusion, and discuss the implications for retroviral membrane fusion...
  59. ncbi Relation between phylogeny of African green monkey CD4 genes and their respective simian immunodeficiency virus genes
    A Fomsgaard
    Statens Serum Institut, Technical University of Denmark, Copenhagen, Denmark
    J Med Primatol 26:120-8. 1997
    ..CD4 sequencing is suggested as a relevant method for genetic determination of primate species...
  60. ncbi Syncytin is involved in breast cancer-endothelial cell fusions
    B Bjerregaard
    Anatomy and Cell Biology, IBHV, KVL, Gronnegaardsvej 7, 1870 Frederiksberg C, Copenhagen, Denmark
    Cell Mol Life Sci 63:1906-11. 2006
    ..Moreover, a syncytin inhibitory peptide also inhibits fusions between cancer and endothelial cells. These results are the first to show that syncytin is expressed by human cancer cells and is involved in cancer-endothelial cell fusions...
  61. pmc The avian retrovirus avian sarcoma/leukosis virus subtype A reaches the lipid mixing stage of fusion at neutral pH
    Laurie J Earp
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 77:3058-66. 2003
    ..Possible roles for low pH at subsequent stages of viral entry are discussed...
  62. pmc Lack of effect of cytoplasmic tail truncations on human immunodeficiency virus type 2 ROD env particle release activity
    S P Bour
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 73:778-82. 1999
    ....
  63. pmc Amphotropic murine leukaemia virus envelope protein is associated with cholesterol-rich microdomains
    Christiane Beer
    Molecular Biotechnology, German Research Centre for Biotechnology, GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Virol J 2:36. 2005
    ..g., measles virus and human immunodeficiency virus. For these viruses association of newly synthesized viral proteins with lipid rafts has been shown...
  64. pmc Transgenic Fv-4 mice resistant to Friend virus
    T I Limjoco
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:4163-8. 1993
    ..The phenotype of recovery from viremia in Fv4-11 mice was unexpected and suggests that low levels of expression of the Fv-4 gene enhance the effectiveness of the immune response...
  65. ncbi Expression analyses of human endogenous retroviruses (HERVs): tissue-specific and developmental stage-dependent expression of HERVs
    Goichi Okahara
    Department of Molecular Biology, Ryukyu University School of Medicine, 207 Uehara, Okinawa 903 0215, Japan
    Genomics 84:982-90. 2004
    ..Term placentas in general showed larger interindividual differences in HERV expression levels. Our results suggest that HERVs might have more diverse effects than currently thought...
  66. pmc Evolution of the human immunodeficiency virus envelope gene is dominated by purifying selection
    C T T Edwards
    Nuffield Department of Clinical Medicine, University of Oxford, UK, and Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Genetics 174:1441-53. 2006
    ..This suggests the presence of deleterious mutations. We therefore conclude that intrahost HIV-1 evolution in envelope is dominated by purifying selection against low-frequency deleterious mutations that do not reach fixation...
  67. ncbi Detecting the expression of human endogenous retrovirus E envelope transcripts in human prostate adenocarcinoma
    Feng Wang-Johanning
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer 98:187-97. 2003
    ..The authors report that, in the current study, transcripts encoding the envelope region of an HERV family, HERV-E, were expressed in human prostate carcinoma...
  68. pmc Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae
    Anne Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unite Mixte de Recherche, 8122 Centre National de la Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif, France
    Proc Natl Acad Sci U S A 102:725-30. 2005
    ....
  69. ncbi Retroviral genomic RNAs are transported to the plasma membrane by endosomal vesicles
    Eugenia Basyuk
    IGMM CNRS UMR5535, Universite Montpellier II, IFR 24, 1919, route de Mende, 34293 Cedex 5, Montpellier, France
    Dev Cell 5:161-74. 2003
    ..This may allow retroviruses to hijack the endosomal machinery as part of their biosynthetic pathway. More generally, tethering to vesicles may provide an efficient mechanism for directed RNA transport...
  70. ncbi Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
    J Lama
    La Jolla Institute for Allergy and Immunology Molecular Immunology Division, 10355 Science Center Drive, San Diego, California 92121, USA
    Curr Biol 9:622-31. 1999
    ..Such functional convergence strongly suggests that CD4 downregulation is critical for optimal viral replication, yet the significance of this phenomenon has so far remained a puzzle...
  71. pmc Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4
    R L Willey
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 66:7193-200. 1992
    ....
  72. pmc Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein
    P L Earl
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 65:2047-55. 1991
    ..The results are discussed in terms of the overall biosynthetic pathway of the envelope protein and provide a framework with which to assess the effects of mutations on structure and function...
  73. ncbi Diversity considerations in HIV-1 vaccine selection
    Brian Gaschen
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 296:2354-60. 2002
    ..Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half...
  74. ncbi Correlation between disease severity and in vitro cytokine production mediated by MSRV (multiple sclerosis associated retroviral element) envelope protein in patients with multiple sclerosis
    Alexandre Rolland
    Laboratoire d Immunochimie, CEA INSERM U548, 17 rue des Martyrs 38054 Grenoble, France
    J Neuroimmunol 160:195-203. 2005
    ..Altogether our data suggest that MSRV envelope protein may induce an abnormal cytokine secretion, thus contributing to the inflammatory process in MS...
  75. pmc Sequential roles of receptor binding and low pH in forming prehairpin and hairpin conformations of a retroviral envelope glycoprotein
    Shutoku Matsuyama
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
    J Virol 78:8201-9. 2004
    ....
  76. pmc Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
    Maria Castedo
    Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    EMBO J 21:4070-80. 2002
    ..Cdk1 inhibition prevents the death of syncytia elicited by HIV-1 infection of primary CD4 lymphoblasts. Thus, HIV-1 elicits a pro-apoptotic signal transduction pathway relying on the sequential action of cyclin B-Cdk1, mTOR and p53...
  77. pmc Perinatal transmission of major, minor, and multiple maternal human immunodeficiency virus type 1 variants in utero and intrapartum
    R E Dickover
    Department of Pediatrics, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 75:2194-203. 2001
    ..These data indicate that different selective pressures, depending on the timing of transmission, may be involved in determining the pattern of maternal HIV-1 variant transmission...
  78. pmc The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses
    S Bour
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
    J Virol 70:8285-300. 1996
    ..HIV-1 and HIV-2 thus appear to have evolved genetically distinct but functionally similar strategies to resolve the common problem of efficient release of progeny virus from infected cells...
  79. pmc The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]
    S Wyss
    Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, Switzerland
    J Virol 75:2982-92. 2001
    ..Finally, the C-terminal dileucine was shown to assist the membrane-proximal Y712 motif in restricting the cell surface expression of Env...
  80. ncbi GCMa regulates the syncytin-mediated trophoblastic fusion
    Chenchou Yu
    Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan
    J Biol Chem 277:50062-8. 2002
    ..Our results may help to explain the mechanism underlying the cell fusion event specific for syncytiotrophoblast formation...
  81. pmc Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions
    Beda Joos
    University Hospital Zurich, Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, Ramistrasse 100, CH 8091 Zurich, Switzerland
    J Virol 79:9026-37. 2005
    ....
  82. ncbi Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta
    Alan Smallwood
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London SE5 9RS, United Kingdom
    Biol Reprod 69:286-93. 2003
    ..Therefore, the relative levels of 3.1 kb and 8 kb mRNAs in trophoblasts could regulate syncytin protein synthesis, possibly by competition of the two mRNA species for translational apparatus...
  83. pmc Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus
    Elena Chertova
    AIDS Vaccine Program, SAIC Frederick, Maryland 21702 1201, USA
    J Virol 76:5315-25. 2002
    ..These findings suggest that incorporation of SU-TM complexes into the viral membrane may be the primary factor determining the quantity of SU associated with SIV and HIV-1 virions, rather than shedding of SU from mature virions...
  84. ncbi Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta
    Reiner Strick
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054, Erlangen, Germany
    J Mol Med (Berl) 85:23-38. 2007
    ..Interactions between Syncytin-1 and TGF-beta may contribute to the etiology of EnCa progression and also help to clarify the regulation of cell-cell fusions occurring in development and in other syncytial cell tumors...
  85. ncbi Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design
    P W Parren
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Lett 57:105-12. 1997
    ..Potential vaccines should be designed to elicit responses against native envelope...
  86. pmc A study of low pH-induced refolding of Env of avian sarcoma and leukosis virus into a six-helix bundle
    R M Markosyan
    Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Biophys J 87:3291-8. 2004
    ..This suggests that the six-helix bundle can form before hemifusion and that subsequent conformational changes, such as formation of the trimeric hairpin, are responsible for pore formation and/or growth...
  87. pmc Directed evolution of retrovirus envelope protein cytoplasmic tails guided by functional incorporation into lentivirus particles
    Christoph A Merten
    Division of Medical Biotechnology, Paul Ehrlich Institut, Paul Ehrlich Str 51 59, 63225 Langen, Germany
    J Virol 79:834-40. 2005
    ..Interestingly, in some of the selected variants, the R-peptide cleavage site had shifted closer to the C terminus. These data demonstrate a valuable approach for the engineering of chimeric viruses and vector particles...
  88. pmc Identification, phylogeny, and evolution of retroviral elements based on their envelope genes
    L Benit
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS UMR 1573, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Virol 75:11709-19. 2001
    ....
  89. ncbi Selective pressures of human immunodeficiency virus type 1 (HIV-1) during pediatric infection
    Elcio Leal
    Federal University of Sao Paulo, Sao Paulo, Brazil
    Infect Genet Evol 7:694-707. 2007
    ..The second region, restricted to amino acids 334-368 of Gp160, contains sites that might increase viral fitness during interhost transmission at the population level...
  90. pmc Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages
    Brandon L Walter
    Rocky Mountain Laboratories, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 79:4828-37. 2005
    ..Thus, the limited expression of CD4 on macrophages or other cell types could serve as a selective factor for V1 and V2 envelope sequences, and this selection could in turn influence many aspects of AIDS pathogenesis in vivo...
  91. pmc Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses
    Yi Liu
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    Virology 374:229-33. 2008
    ....
  92. pmc Human immunodeficiency virus type 1 Gag contains a dileucine-like motif that regulates association with multivesicular bodies
    O Wolf Lindwasser
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 143, New York, NY 10021, USA
    J Virol 78:6013-23. 2004
    ..We propose that HIV-1 Gag contains a signal that promotes interaction with the cellular endocytic machinery and that the site of particle production is regulated by the subcellular distribution of cholesterol...
  93. pmc Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry
    Z Chen
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 71:2705-14. 1997
    ..These findings indicated that, in addition to CCR5, SIV can use one or more unknown coreceptors that are expressed on human PBMCs and CEMx174 cells...
  94. ncbi Structural and immunogenicity analysis of chimeric B-cell epitope constructs derived from the gp46 and gp21 subunits of the envelope glycoproteins of HTLV-1
    R Sundaram
    Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH 43210, USA
    J Pept Res 63:132-40. 2004
    ..The applicability of a chimeric approach is discussed in the context of recent findings regarding the role of gp21 transmembrane region in the viral fusion process...
  95. pmc Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease
    Hong Zhang
    Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA
    Retrovirology 3:73. 2006
    ..We investigated the possible influence of viral genotype and humoral immune response on disease progression in infants...
  96. ncbi An essential role for the His-8 residue of the SDF-1alpha-chimeric, tropism-redirected Env protein of the Moloney murine leukemia virus in regulating postbinding fusion events
    Masumi Katane
    Molecular Cell Science Laboratory, Discovery Research Institute, RIKEN, Wako, Saitama 351 0198, Japan
    J Gene Med 6:260-7. 2004
    ....
  97. ncbi Role of HIV-2 envelope in Lv2-mediated restriction
    Sandra Reuter
    Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Virology 332:347-58. 2005
    ..A remaining restriction to infection (19-fold) is preserved when endosomal acidification is prevented. This restriction to infection is also dependent on the presence of the point mutation at position 74 (G74E)...
  98. pmc Determinants of high titer in recombinant porcine endogenous retroviruses
    Ian Harrison
    National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    J Virol 78:13871-9. 2004
    ..Taken together, these results show that the novel juxtaposition of env gene sequences enhanced the infectivity of PERV-A14/220 for human cells, perhaps by stabilization of the envelope glycoprotein or increased receptor binding...
  99. ncbi Quantitative analysis of human endogenous retrovirus-W env in neuroinflammatory diseases
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    AIDS Res Hum Retroviruses 22:1253-9. 2006
    ..033 log10/ml versus MS: 2.9 log10/ml). These observations emphasize the selective induction of syncytin-1 in brain tissue of MS patients but also illustrate the complex dynamics of this retroelement in neuroinflammatory processes...
  100. ncbi Prognostic role of syncytin expression in breast cancer
    Lars Inge Larsson
    Department of Anatomy and Cell Biology, IBHV, KVL, Frederiksberg C, Copenhagen, Denmark
    Hum Pathol 38:726-31. 2007
    ..Thus, syncytin expression constitutes a positive prognostic factor in breast cancer--a phenomenon that may be related to the involvement of syncytin in mediating fusions between breast cancer cells and endothelial cells...
  101. ncbi Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
    D Weissman
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 389:981-5. 1997
    ..Alternatively, envelope-mediated CCR5 signal transduction may influence viral-associated cytopathicity or apoptosis...

Research Grants62

  1. Intersubtype recombinants for polyvalent anti-HIV vaccine
    Yong Gao; Fiscal Year: 2013
    ....
  2. Optimization of HIV vaccines for the induction of cross-reactive antibodies
    Shan Lu; Fiscal Year: 2013
    ..RELEVANCE: To optimize the next generation polyvalent Env HIV vaccine formulations using the multi-gene, polyvalent DNA prime - protein boost technology platform. ..
  3. Single-particle Reconstruction of HIV-1 Envelope Glycoprotein Trimers
    Joseph G Sodroski; Fiscal Year: 2013
    ..We will develop methods in electron microscopy that allow a detailed structural blueprint of the HIV-1 envelope glycoprotein spike to be realized. ..
  4. Engineered lipid vesicles as potent vaccine vectors for HIV
    Darrell J Irvine; Fiscal Year: 2013
    ....
  5. Broadly Reactive Antibodies Against Chimeric Virus-Host Antigens
    Donald N Forthal; Fiscal Year: 2013
    ..We propose an exceptionally novel approach to discover such immunogens. If successful, this research may lead directly to a vaccine that prevents HIV infection. ..
  6. Endogenous retroviruses and gene regulation after injury
    Kiho Cho; Fiscal Year: 2010
    ..Furthermore, the findings from this study may lead to a further investigation into the development of a novel therapeutic protocol for burn patients in combination with current regimens. ..
  7. T-follicular helper cells in Env-immunized macaques
    CHARLES DAVID PAUZA; Fiscal Year: 2013
    ..There have been few efforts to determine mechanisms underlying the well-known transient antibody responses to Env glycoproteins. Our work concentrates on one aspect of antibody generation and tests its relationship to vaccine efficacy. ..
  8. Induction of neutralizing antibodies targeting CD4 binding region of HIV-1 Env
    Shan Lu; Fiscal Year: 2013
    ..Goal 5: To provide support to major projects on structure analysis of Env and to study the structure of novel antigens, and antigen-antibody interactions (Core A). ..
  9. Polyvalent DNA Plus Protein HIV Vaccines
    Shan Lu; Fiscal Year: 2010
    ..This will allows us to effectively screen a large number of unique primary Env antigens to formulate the effective polyvalent HIV vaccines for the next phase of clinical testing. ..
  10. High Mannose Type Carbohydrate-based HIV/AIDS Vaccine
    Yu Geng; Fiscal Year: 2009
    ..If success, this novel formulation of immunogen from yeast mutant strain will be a safe, cheap, and effective HIV/AIDS vaccine against a broad range of HIV-1 primary isolates. ..
  11. MUCOSAL IMMUNITY TO HIV ENV BY ORAL VACCINATION
    Danuta Kozbor; Fiscal Year: 2001
    ..vaccination with plasmid DNA encoding gp160 in combination with recombinant viral vectors expressing the env gene products to enhance the antigen-specific mucosal and systemic immunity...
  12. Nipah Virus Pathobiology and Effects on Innate Immunity
    Linda Baum; Fiscal Year: 2009
    ..The co-investigators have a unique combination of expertise, and propose an innovative set of studies into the glycobiology of NiV pathogenesis. ..
  13. Development of a rapid glycosylation profiling system using mass spec data
    HEATHER R DESAIRE; Fiscal Year: 2012
    ..abstract_text> ..
  14. STRUCTURE/FUNCTION ANALYSIS OF THE HIV ENV GENE PRODUCT
    Eric Hunter; Fiscal Year: 2003
    ....
  15. Mechanism of p12I and p30II in HTLV1 Infection
    Michael Lairmore; Fiscal Year: 2003
    ..This complex retrovirus encodes typical gag, pol, and env gene products, as well as unique regulatory and accessory genes encoded in pX ORF I-IV between the env gene and the 3' LTR...
  16. HIV-1 DNA VACCINES THAT TARGET AND ACTIVATE CD40
    JEFFREY LEDBETTER; Fiscal Year: 2001
    ..Antibody responses towards HIV-1 env will be tested by epitope specific ELISA assays and viral neutralization assays. ..
  17. ALTERATIONS OF ION TRANSPORT BY HIV
    Robert Garry; Fiscal Year: 2000
    ..The env gene products, SU (gpl20) and TM (gp4l) have been implicated in HIV cytopathogenesis...
  18. GLYCOSYLATION OF SIV GP120--ROLE IN THE IMMUNE RESPONSE
    NORMAN SALZMAN; Fiscal Year: 1991
    ..persons show humoral and cell-mediated immune responses to HIv antigens and in particular to the env gene products of HIV, the external envelope glycoprotein gp120 (EEG)...
  19. Novel Chimeric Env Glycoproteins for AIDS Vaccines
    Ling Ye; Fiscal Year: 2005
    ..We will also test the effectiveness of different priming-boosting protocols in eliciting cross-reactive neutralizing antibodies against HIV. ..
  20. Multi-component HIV Vaccines Using Engineered Envelopes
    Susan Barnett; Fiscal Year: 2004
    ..These efforts are expected to lead to the selection of a strong candidate vaccine regimen for future clinical evaluations. ..
  21. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2004
    ..Understanding this process in detail should lead to better antiviral therapeutic strategies and aid with viral targeting approaches for gene therapy protocols. ..
  22. Development of Novel Immunogens for Vaccines to HIV-1
    Robert Whalen; Fiscal Year: 2009
    ..In a third aim, various formats of Env will be tested to determine which one is optimal for presenting the most immunogenic Env sequences. Virus-like particles in which the Env complex is stabilized will be targeted. ..
  23. Creation of Stable Cleaved Trimers of the HIV-1 Envelope Protein
    Robert Whalen; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  24. Studies of p30 II and p13 II in HTLV-1 Infection
    Michael Lairmore; Fiscal Year: 2004
    ..This complex retrovirus encodes typical gag, pol, and env gene products, as well as unique regulatory and accessory genes encoded in pX ORF I-IV...
  25. DNA Vaccines With HIV Virus-like Particles
    Ted Ross; Fiscal Year: 2003
    ..elicit both humoral and cell-mediated immune responses to the major structural proteins of HIV, the Gag and Env gene products. The VLP has safety mutations designed into vaccine in order to meet U.S...
  26. Novel HIV-1 vaccine candidates using newly transmitted clade C Envs as immunogens
    Jerry L Blackwell; Fiscal Year: 2010
    ..abstract_text> ..
  27. HIV ENV TRANSMEMBRANE DOMAIN AND FUSION
    RANDALL OWENS; Fiscal Year: 1999
    ....
  28. NOVEL VERTEBRATE PROTEIN PRODUCTION--HIV
    David Kabat; Fiscal Year: 1991
    ..These studies will thoroughly characterize a novel and promising method for producing vertebrate proteins, and will also result in important information about leukemia and AIDS...
  29. Targeting HIV-1 Envelope glycoprotein incorporation
    Juan Lama; Fiscal Year: 2009
    ..We propose to identify and characterize antiretroviral compounds that block HIV through a novel mechanism. These unique compounds could be used for the treatment of HIV infection. ..
  30. REGULATION OF HIV ENV FUNCTION DURING VIRION MATURATION
    Christopher Aiken; Fiscal Year: 2007
    ..These studies will reveal new fundamental insights into the regulation of HIV-t entry and the role of the gp41 cytoplasmic tail in HIV-1 replication. ..
  31. MUCOSALLY DELIVERED DNA/MVA VACCINES IN A SHIV MODEL
    Thomas VanCott; Fiscal Year: 2004
    ..6PD will be evaluated and correlated with mucosal and system immunogenicity parameters. By relating these results to challenge studies, insight may be gained into correlates of protection at mucosal surfaces. ..
  32. Clinical Relevance of Transient Nevirapine Resistance
    Louise Kuhn; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  33. Chimeric Adenovirus Vaccine Vectors for HIV/SIV
    DAN BAROUCH; Fiscal Year: 2005
    ..Within the two-year time frame of this award, sufficient data will be generated with candidate chimeric rAd vaccines to justify further vaccine/challenge studies in rhesus monkeys. ..
  34. A Universal Env Immunogen for all HIV-1 Subtypes
    Feng Gao; Fiscal Year: 2004
    ..Results from this study will determine if con/con Env protein can serve as a universal immunogen for all HIV-1 subtypes and will be used as a guideline to design broadly reactive immunization strategies. ..
  35. Pathogenesis of Essential Tremor: Cerebellar Metabolism
    Elan Louis; Fiscal Year: 2008
    ..abstract_text> ..
  36. Immunogenicity of an HIV virus-like particle vaccine
    Feng Gao; Fiscal Year: 2004
    ..abstract_text> ..
  37. Augmentation of DNA Vaccine-Elicited Immunity to HIV/SIV
    DAN BAROUCH; Fiscal Year: 2008
    ..The long-term objectives of these studies are to develop novel vaccine regimens that recruit APCs to the site of inoculation in animal models and to consider advancing the most promising strategies into clinical trials. ..
  38. Receptor usage and pathogenicity of feline lentiviruses
    BRIAN WILLETT; Fiscal Year: 2007
    ..abstract_text> ..
  39. Cytokine-Augmented DNA Vaccine-Elicited Immunity to HIV
    DAN BAROUCH; Fiscal Year: 2005
    ..Raphael Dolin, Dean for Clinical Programs, Harvard Medical School, will guide Dr. Barouch's development as an independent investigator. In addition, a committee of distinguished scientists will oversee his progress toward independence. ..
  40. IMMUNE CONTROL OF CAE LENTIVIRUS
    Donald Knowles; Fiscal Year: 2005
    ..Therefore, the second objective of this proposal is to evaluate virus replication following CAEV challenge of goats co-immunized with plasmid DNA expressing CAEV env and tat genes and caprine IFN. ..
  41. HIV Protective Immunity and Perinatal Exposure
    Louise Kuhn; Fiscal Year: 2006
    ..abstract_text> ..
  42. Role of Virus Recombination in Multiple Drug Resisitance
    Feng Gao; Fiscal Year: 2007
    ..Knowledge obtained from this study can be broadly applied toward understanding mechanisms of viral escape from immune surveillance and other selective forces. ..
  43. Novel Adenovirus Vaccine Vectors for HIV/SIV
    Dan H Barouch; Fiscal Year: 2010
    ..abstract_text> ..
  44. Recombinant Sendai Virus as a Novel HIV Vaccine Vector
    KAREN SLOBOD; Fiscal Year: 2004
    ..Studies described in this application may ultimately identify rSV as an effective intranasal vaccine vehicle useful in the prevention of HIV. ..
  45. NEUTRALIZATION RESISTANCE OF HIV-1
    Gerald Quinnan; Fiscal Year: 2005
    ..Neutralization sensitivity and immunogenicity of envelopes from similar donors will be studied. These findings are highly relevant to vaccine development. ..
  46. BIOLOGY OF PEDIATRIC HEPATITIS C INFECTION
    William Borkowsky; Fiscal Year: 2001
    ..The influence of both maternal and child alleles on transmission will be assessed. The correlation of immune responses measured in AIM 3 and the clinical outcome of HCV infection with HLA alleles in the child will be studied. ..
  47. HIV 1 RECOMBINANTS TRANSMITTED PERINATALLY
    Boris Renjifo; Fiscal Year: 2002
    ..This study may provide information that will eventually be useful for decreasing rates of perinatal infection. ..
  48. IMMUNE CONTROL OF EQUINE INFECTIOUS ANEMIA LENTIVIRUS
    Travis McGuire; Fiscal Year: 2002
    ....
  49. BEHAVIORAL AND VIROLOGIC FEATURES OF HIV+ IDUS IN CHINA
    Xiao Fang Yu; Fiscal Year: 2002
    ..These aims will be carried out in Guangxi Province through a longitudinal investigation of 600 drug users about whom demographic, social, and drug use information will be collected and analyzed. ..
  50. Identifying determinants of Hepatitis C Virus (HCV) tropism
    Tatjana Dragic; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  51. Modulation of HBV Replication by the Immunoproteasome
    Michael Robek; Fiscal Year: 2006
    ..These studies may provide a better understanding of the host factors that modulate HBV replication and that ultimately determine the outcome of infection. ..
  52. DESIGN OF NOVEL IMMUNOGENS AND ADJUVANTS FOR HIV VACCINE
    Barton Haynes; Fiscal Year: 2003
    ..abstract_text> ..
  53. New Model for NeuroAIDS Utilizing Monocyte-Derived HIV-1
    Tuofu Zhu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. NCRR FACSAria Cell Sorter
    Barton Haynes; Fiscal Year: 2004
    ..Advisory committees, institutional support, financial support for continued maintenance, and management plans are in place to insure that the instrument will be fully and appropriately utilized. ..
  55. Role of CD14+ Monocytes in HIV-1 Infection
    Tuofu Zhu; Fiscal Year: 2005
    ..Findings from this proposal will provide better understanding of productive infection of HIV-1 in CD 14+ monocytes in vivo, and may also provide great insights to developing new therapeutic strategies to enhance therapy efficacy. ..
  56. Conference HIV Vaccine Development Progress & Prospects
    Norman Letvin; Fiscal Year: 2004
    ..abstract_text> ..
  57. Minimal Levels of HIV-1 in Vaccinated & Exposed Persons
    Tuofu Zhu; Fiscal Year: 2007
    ..These studies should assist definition of virologic and immunologic characteristics required to attenuate and/or substantially control HIV-1 infection, a critical goal of AIDS vaccine development. ..
  58. Mucosal and Peripheral NK-T Cells in HIV Infection
    Otto Yang; Fiscal Year: 2007
    ..Exploring NK-T cells in HIV-1 infection could there have a high impact on the development of new strategies in prevention and treatment. [unreadable] [unreadable]..