s100 proteins

Summary

Summary: A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF-HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.

Top Publications

  1. ncbi S100 proteins: structure, functions and pathology
    Claus W Heizmann
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Front Biosci 7:d1356-68. 2002
  2. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
  3. ncbi S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
    Dirk Foell
    Department of Pediatrics, Institute of Experimental Dermatology, University of Muenster Albert Schweitzer Str 33, Muenster D 48149, Germany
    J Leukoc Biol 81:28-37. 2007
  4. doi Regulation of fibrinolysis by S100A10 in vivo
    Alexi P Surette
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS
    Blood 118:3172-81. 2011
  5. pmc S100A4 and metastasis: a small actor playing many roles
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Am J Pathol 176:528-35. 2010
  6. ncbi Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type
    R Donato
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
    Biochim Biophys Acta 1450:191-231. 1999
  7. doi S100B's double life: intracellular regulator and extracellular signal
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Biochim Biophys Acta 1793:1008-22. 2009
  8. doi S100B protein in neurodegenerative disorders
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Clin Chem Lab Med 49:409-24. 2011
  9. ncbi Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers
    S S Cross
    Academic Unit of Pathology, Division of Genomic Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Histopathology 46:256-69. 2005
  10. ncbi The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer
    Ulrike Stein
    Department of Surgery and Surgical Oncology, Robert Rössle Cancer Hospital, Charite Campus Buch, Berlin, Germany
    Gastroenterology 131:1486-500. 2006

Research Grants

Detail Information

Publications307 found, 100 shown here

  1. ncbi S100 proteins: structure, functions and pathology
    Claus W Heizmann
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Front Biosci 7:d1356-68. 2002
    b>S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation...
  2. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
    ..As a general mechanism, this change in fate highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions...
  3. ncbi S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
    Dirk Foell
    Department of Pediatrics, Institute of Experimental Dermatology, University of Muenster Albert Schweitzer Str 33, Muenster D 48149, Germany
    J Leukoc Biol 81:28-37. 2007
    ..One example known for many years to be expressed in cells of myeloid origin are phagocytic S100 proteins, which mediate inflammatory responses and recruit inflammatory cells to sites of tissue damage...
  4. doi Regulation of fibrinolysis by S100A10 in vivo
    Alexi P Surette
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS
    Blood 118:3172-81. 2011
    ..These results establish an important role for S100A10 in the regulation of fibrinolysis and angiogenesis in vivo, suggesting S100A10 plays a critical role in endothelial cell function...
  5. pmc S100A4 and metastasis: a small actor playing many roles
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Am J Pathol 176:528-35. 2010
    ..In this review, we summarize the evidence connecting S100A4 and cancer metastasis and discuss the mechanisms by which S100A4 promotes tumor progression...
  6. ncbi Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type
    R Donato
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
    Biochim Biophys Acta 1450:191-231. 1999
    ..Thus, any S100 dimer is suggested to expose two binding surfaces on opposite sides, which renders homodimeric S100 proteins ideal for crossbridging two homologous or heterologous target proteins...
  7. doi S100B's double life: intracellular regulator and extracellular signal
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Biochim Biophys Acta 1793:1008-22. 2009
    ..Future studies using S100B transgenic and S100B null mice might shed more light on the functional role(s) of the protein...
  8. doi S100B protein in neurodegenerative disorders
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Clin Chem Lab Med 49:409-24. 2011
    ..Moreover, there is no consistent evidence for a correlation between disease severity and concentrations of S100B in CSF or serum. Therefore, S100B has limited usefulness for monitoring disease progression...
  9. ncbi Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers
    S S Cross
    Academic Unit of Pathology, Division of Genomic Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Histopathology 46:256-69. 2005
    ..S100A6, S100A8, S100A9 and S100A11 have all been suggested to have potential roles in carcinogenesis and tumour progression but their expression has not been described in a wide range of human tissues and tumours...
  10. ncbi The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer
    Ulrike Stein
    Department of Surgery and Surgical Oncology, Robert Rössle Cancer Hospital, Charite Campus Buch, Berlin, Germany
    Gastroenterology 131:1486-500. 2006
    ..Our aim was to elucidate the impact of gain-of-function beta-catenin on the metastasis-associated gene S100A4 in human colon cancer cell lines and tumors...
  11. doi The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
    Sachie Hiratsuka
    Department of Pharmacology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Nat Cell Biol 10:1349-55. 2008
    ..Thus, blocking SAA3-TLR4 function in the pre-metastatic phase could prove to be an effective strategy for the prevention of pulmonary metastasis...
  12. pmc S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9
    Mohammad Saleem
    Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:14825-30. 2006
    ..We suggest that S100A4 could be used as a biomarker for CaP progression and a novel therapeutic or chemopreventive target for human CaP treatment...
  13. ncbi Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implications
    Giuseppina Basta
    CNR, Institute of Clinical Physiology, San Cataldo Research Area, Via Moruzzi 1, 56124 Pisa, Italy
    Atherosclerosis 196:9-21. 2008
    ..In the atherosclerotic milieu, three classes of RAGE ligands, i.e., products of non-enzymatic glycoxidation, S100 proteins and amphoterin, appear to drive receptor-mediated cellular activation and potentially, acceleration of ..
  14. ncbi An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface
    Arunkumar B Deora
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 279:43411-8. 2004
    ..Translocation of annexin 2 to the cell surface dramatically increases tissue plasminogen activator-dependent plasminogen activation potential and may represent a novel stress-induced protein secretion pathway...
  15. ncbi S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors
    Mijung Kwon
    Department of Biochemistry, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1, Canada
    Front Biosci 10:300-25. 2005
    ..This review highlights the important part that S100A10 plays in plasmin regulation and the role this protein plays in cancer cell invasiveness and metastasis...
  16. pmc Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11
    Kai Li He
    Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 283:19192-200. 2008
    ..This mechanism prevents accumulation of free p11 in the endothelial cell and suggests that regulation of tPA-dependent cell surface fibrinolytic activity is precisely tuned to the intracellular level of p11...
  17. ncbi Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection
    Regine Gläser
    Clinical Research Unit of the Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Nat Immunol 6:57-64. 2005
    ..Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism. Thus, psoriasin may be key to the resistance of skin against E. coli...
  18. doi Regulation of S100A10 by the PML-RAR-α oncoprotein
    Paul A O'Connell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, USA
    Blood 117:4095-105. 2011
    ..These experiments show that S100A10 plays a crucial role in the generation of plasmin leading to fibrinolysis, thus providing a link to the clinical hemorrhagic phenotype of APL...
  19. doi Inflammation-associated S100 proteins: new mechanisms that regulate function
    Jesse Goyette
    Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia
    Amino Acids 41:821-42. 2011
    ..Conversely, S100A8 and S100A9 oxidation and S-nitrosylation may have important protective mechanisms in inflammation...
  20. ncbi Thrombin induces endothelial cell-surface exposure of the plasminogen receptor annexin 2
    Erica A Peterson
    Canadian Blood Services, R and D Department, 1800 Alta Vista Drive, Ottawa, ON K1G 4J5, Canada
    J Cell Sci 116:2399-408. 2003
    ..These data suggest a novel mechanism that links the coagulation and fibrinolysis pathways by thrombin-mediated feedback...
  21. pmc Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition
    Young Tae Lee
    Departments of Biochemistry and Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 47:10921-32. 2008
    ..A series of structure-based SIP mutations showed reduced S100A6 binding affinity, setting the stage for direct functional analysis of S100A6-SIP interactions...
  22. pmc RAGE signaling sustains inflammation and promotes tumor development
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 205:275-85. 2008
    ..We show that RAGE signaling drives the strength and maintenance of an inflammatory reaction during tumor promotion and provide direct genetic evidence for a novel role for RAGE in linking chronic inflammation and cancer...
  23. ncbi Mts1 regulates the assembly of nonmuscle myosin-IIA
    Zhong hua Li
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:14258-66. 2003
    ..Altogether, these observations are consistent with mts1 regulating myosin IIA assembly by monomer sequestration and suggest that mts1 regulates cell shape and motility through the modulation of myosin-IIA function...
  24. doi S100A6 - new facts and features
    Wiesława Leśniak
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 390:1087-92. 2009
    ..Additionally, S100A6 might have some extracellular activities. This review presents new facts and features concerning the S100A6 protein...
  25. doi S100A10 regulates plasminogen-dependent macrophage invasion
    Paul A O'Connell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Blood 116:1136-46. 2010
    ..This study establishes a direct involvement of S100A10 in macrophage recruitment in response to inflammatory stimuli...
  26. pmc Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex
    Stan F J van de Graaf
    Department of Cell Physiology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    EMBO J 22:1478-87. 2003
    ..In conclusion, the S100A10-annexin 2 complex plays a crucial role in routing of TRPV5 and TRPV6 to plasma membrane...
  27. doi Human S100A12: a novel key player in inflammation?
    Jens Pietzsch
    Department of Radiopharmaceutical Biology, Institute of Radiopharmacy, Research Center Dresden Rossendorf, POB 51 01 19, 01314 Dresden, Germany
    Amino Acids 36:381-9. 2009
    ..Recent clinical evidence suggests a high potential of S100A12 as a sensitive and specific diagnostic marker of localized inflammatory processes...
  28. ncbi S-100B and neuron-specific enolase in serum of mild traumatic brain injury patients. A comparison with health controls
    J R de Kruijk
    Neurology Dept University Hospital Maastricht, The Netherlands
    Acta Neurol Scand 103:175-9. 2001
    ..The aim of the study was to determine whether serum concentrations of neuron-specific enolase (NSE) and S100-B in mild traumatic brain injury (MTBI) patients are higher than in serum of healthy controls...
  29. pmc S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy
    Steven Greenway
    Division of Cardiovascular Research, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 164:253-62. 2004
    ..The relationship of increased S100A4/Mts1 to pathologically similar lesions in the transgenic mice and patients occurs despite differences in localization (endothelial versus smooth muscle cells)...
  30. ncbi Alterations in 5-HT1B receptor function by p11 in depression-like states
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA
    Science 311:77-80. 2006
    ..p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant...
  31. ncbi Proinflammatory S100 proteins in arthritis and autoimmune disease
    Dirk Foell
    Interdisciplinary Center for Clinical Research, University of Muenster, Muenster, Germany
    Arthritis Rheum 50:3762-71. 2004
  32. ncbi S100A10/p11: family, friends and functions
    Ursula Rescher
    Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Muenster, Von Esmarch Str 56, 48149 Muenster, Germany
    Pflugers Arch 455:575-82. 2008
    ..In contrast to all other S100 proteins, S100A10 is Ca(2+) insensitive because of amino acid replacements in its Ca(2+)-binding loops that lock the ..
  33. doi Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase
    Masahiro Honda
    Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Yamaguchi, Japan
    J Trauma 69:104-9. 2010
    ..In this study, serum GFAP, S-100B, and neuron-specific enolase (NSE) were compared in the same samples from severe trauma patients to assess their ability to predict abnormalities detectable on head computed tomography (CT)...
  34. doi The role of S100 genes in breast cancer progression
    Eadaoin McKiernan
    Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Tumour Biol 32:441-50. 2011
    ..Based on our findings, we conclude that the different S100 genes play varying roles in breast cancer progression. Specific S100 genes are potential targets for the treatment of basal-type breast cancers...
  35. pmc Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer
    Ronald Wolf
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    Cancer Lett 277:101-7. 2009
    ..The differential regulation, expression and distribution of hS100A7 and hS100A15 and their reported distinct functions are compelling reasons to discriminate among these proteins in normal breast and breast cancers...
  36. pmc S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways
    Mohd W Nasser
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 72:604-15. 2012
    ..In summary, our work used a powerful new model system to show that S100A7 enhances breast tumor growth and metastasis by activating proinflammatory and metastatic pathways...
  37. ncbi Silencing of the annexin II gene down-regulates the levels of S100A10, c-Myc, and plasmin and inhibits breast cancer cell proliferation and invasion
    Jian Zhang
    Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Saudi Med J 31:374-81. 2010
    ..To explore the roles of annexin II in breast cancer progression, and to study the effect of annexin II on breast cancer cell proliferation and invasion...
  38. ncbi RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 97:889-901. 1999
    ..These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury...
  39. pmc S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cells
    Stina Petersson
    Department of Clinical Genetics, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    BMC Cancer 7:205. 2007
    ..IFN-gamma also exerts anti-tumor action in a number of tumor cell types, including breast cancer. We therefore examined the effect of IFN-gamma and STAT-signaling on the psoriasin expression...
  40. doi The role of the annexin A2 heterotetramer in vascular fibrinolysis
    Patricia A Madureira
    Department of Biochemistry and Molecular Biology Dalhousie University, Halifax, NS, USA
    Blood 118:4789-97. 2011
    ..The AIIt mediated colocalization of the plasminogen activators with plasminogen results in the rapid and localized generation of plasmin to the endothelial cell surface, thereby regulating fibrinolysis...
  41. doi Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli
    Arby Abtin
    Department of Dermatology, Medical University of Vienna, Waehringer Guertal 18 20, 1090 Vienna, Austria
    FASEB J 22:2168-76. 2008
    ..coli supernatant. Taken together, our data demonstrate that bacterial flagellin is essential and sufficient for the induction of S100A7c expression in KCs by E. coli...
  42. ncbi RAGE: a multi-ligand receptor unveiling novel insights in health and disease
    P Alexiou
    Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Greece
    Curr Med Chem 17:2232-52. 2010
    ..Additionally, its potential as an attractive pharmacotherapeutic target will be explored by pointing out the pharmacotherapeutic agents that have been developed for RAGE blockade...
  43. ncbi Pathologies involving the S100 proteins and RAGE
    C W Heizmann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Switzerland
    Subcell Biochem 45:93-138. 2007
    The S100 proteins are exclusively expressed in vertebrates and are the largest subgroup within the superfamily of EF-hand Ca2(+)-binding proteins Generally, S100 proteins are organized as tight homodimers (some as heterodimers)...
  44. ncbi S100 proteins in the epidermis
    Richard L Eckert
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Invest Dermatol 123:23-33. 2004
    The S100 proteins comprise a family of 21 low molecular weight (9-13 kDa) proteins that are characterized by the presence of two calcium-binding EF-hand motifs...
  45. doi Nuclear S100A4 is a novel prognostic marker in colorectal cancer
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Eur J Cancer 46:2919-25. 2010
    ....
  46. pmc The metastasis associated protein S100A4: role in tumour progression and metastasis
    D M Helfman
    Department of Cell Biology and Anatomy, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    Br J Cancer 92:1955-8. 2005
    ..Below we discuss its biochemical properties and possible cellular functions in metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation...
  47. doi The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome
    H Worthmann
    Department of Neurology, Medical School of Hannover, Hannover, Germany
    Cerebrovasc Dis 30:85-92. 2010
    ..The present study aimed to clarify the temporal dynamics of discrete inflammatory markers/mediators for future mechanism-targeting anti-inflammatory strategies in ischemic brain damage...
  48. ncbi Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury
    P E Vos
    Department of Neurology, University Medical Centre Nijmegen, The Netherlands
    Neurology 62:1303-10. 2004
    ..To study the ability of glial (glial fibrillary acidic protein [GFAP] and S100b) and neuronal (neuron specific enolase [NSE]) protein levels in peripheral blood to predict outcome after severe traumatic brain injury...
  49. pmc p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1
    Christophe Girard
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    EMBO J 21:4439-48. 2002
    ..p11 association with the TASK-1 channel masks an endoplasmic reticulum retention signal identified as Lys-Arg-Arg that precedes the Ser-Ser-Val sequence...
  50. ncbi Effects of head and extracranial injuries on serum protein S100B levels in trauma patients
    Olli Savola
    Department of Neurology, Oulu University Hospital, Oulu, Finland
    J Trauma 56:1229-34; discussion 1234. 2004
    ..Serum protein S100B determinations have been recently suggested as markers of traumatic brain injury. However, little is known about the effects of extracranial injuries on S100B levels in trauma patients...
  51. pmc S100A7 and the progression of breast cancer
    Ethan D Emberley
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res 6:153-9. 2004
    ..Subsequent studies have started to describe a functional role for these S100 proteins as well as their mechanism of action and the biochemical pathways they modify...
  52. ncbi S100B in schizophrenia: an update
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Gen Physiol Biophys 28:F76-81. 2009
    ..These findings suggest that the activation of astrocytes might be an important pathogenic factor for the development of schizophrenia...
  53. pmc The 1.5 Å crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding
    HaJeung Park
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:40762-70. 2010
    ..of the pattern recognition receptor, RAGE with key ligands such as advanced glycation end products (AGE), S100 proteins, amyloid β, and HMGB1 has been linked to diabetic complications, inflammatory and neurodegenerative disorders,..
  54. doi S100-B protein as a screening tool for the early assessment of minor head injury
    Drissa Zongo
    Service des urgences adultes, Hopital Pellegrin, Bordeaux, France
    Ann Emerg Med 59:209-18. 2012
    ..We evaluate S100-B protein measurement as a screening tool in a large population of patients with minor head injury...
  55. ncbi Brain- and heart-type fatty acid-binding proteins in the brain: tissue distribution and clinical utility
    Maurice M A L Pelsers
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Clin Chem 50:1568-75. 2004
    ..We investigated the tissue distribution of brain- and heart-type fatty acid-binding proteins (B-FABP and H-FABP) in segments of the human brain and the potential of either protein to serve as plasma marker for diagnosis of brain injury...
  56. doi S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid
    Hye Sook Min
    Department of Pathology, National Cancer Center, Goyang, Gyenggi, Korea
    Mod Pathol 21:748-55. 2008
    ..In conclusion, S100A4 expression in papillary microcarcinomas may indicate the presence of nodal metastasis. Thus, S100A4 immunohistochemistry may be valuable for predicting metastatic potential in papillary microcarcinomas...
  57. doi Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 26:171-9. 2011
    ..The potential of neural-derived IgG autoantibodies as part of a biomarker panel for the diagnosis of Lewy body-associated dementias should be further evaluated...
  58. ncbi Cell-surface attachment of pedestal-forming enteropathogenic E. coli induces a clustering of raft components and a recruitment of annexin 2
    Nicole Zobiack
    Institute for Medical Biochemistry, Center for Molecular Biology of Inflammation, Von Esmarch Str 56, D 48149 Munster, Germany
    J Cell Sci 115:91-8. 2002
    ....
  59. ncbi Intracellular and extracellular roles of S100 proteins
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, 06122 Perugia, Italy
    Microsc Res Tech 60:540-51. 2003
    ..Structural information indicates that most of S100 proteins exist in the form of antiparallelly packed homodimers (in some cases heterodimers), capable of functionally ..
  60. doi The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury
    Jane Topolovec-Vranic
    Trauma and Neurosurgery Program, St Michael s Hospital, Toronto, Canada
    J Trauma 71:S478-86. 2011
    ..To determine, using a civilian model of mild traumatic brain injury (TBI), the added value of biomarker sampling upon prognostication of outcome at 1 week and 6 weeks postinjury...
  61. ncbi S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes
    Mikael Schneider
    The Laboratory of Molecular and Cellular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Medicine B, H S Rigshospitalet, Copenhagen University Hospital, Denmark
    Cardiovasc Res 75:40-50. 2007
    ..We therefore hypothesized that S100A4 could play a supportive role in the injured heart...
  62. doi Can low serum levels of S100B predict normal CT findings after minor head injury in adults?: an evidence-based review and meta-analysis
    Johan Undén
    Department of Anaesthesia and Intensive Care, Halmstad Regional Hospital, Halmstad, Sweden
    J Head Trauma Rehabil 25:228-40. 2010
    ..To determine whether low levels of S100B in serum can predict normal computed tomography (CT) findings after minor head injury (MHI) in adults...
  63. pmc Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-κB in human osteoarthritis chondrocytes
    Zafar Rasheed
    Department of Medicine, Division of Rheumatology, MetroHealth Medical Center Case Western Reserve University, Hamann Bldg, Suite 586, 2500 Metro Health Drive, Cleveland, OH 44109, USA
    Rheumatology (Oxford) 50:838-51. 2011
    ..To investigate whether advanced glycation end products (AGEs) induce the expression of IL-6 and IL-8 through the receptor for AGEs (RAGE)-activated pathways in human OA chondrocytes...
  64. pmc S100B protein stimulates microglia migration via RAGE-dependent up-regulation of chemokine expression and release
    Roberta Bianchi
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, 06122 Perugia, Italy
    J Biol Chem 286:7214-26. 2011
    ..These results suggests that S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE-dependent regulation of several inflammation-related events including activation and migration of microglia...
  65. ncbi Phenotypic and functional characteristics of mesenchymal stem cells differentiated along a Schwann cell lineage
    Jenny Caddick
    Blond McIndoe Research Laboratories, University of Manchester, Manchester, United Kingdom
    Glia 54:840-9. 2006
    ..These findings support the assertion that MSCs can be differentiated into cells that are Schwann cell-like in terms of both phenotype and function...
  66. pmc Nuclear S100A7 is associated with poor prognosis in head and neck cancer
    Satyendra Chandra Tripathi
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 5:e11939. 2010
    ..This study aimed to determine the clinical significance of S100A7 overexpression in HNSCC...
  67. pmc The economic impact of S-100B as a pre-head CT screening test on emergency department management of adult patients with mild traumatic brain injury
    Shuolun Ruan
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurotrauma 26:1655-64. 2009
    ..Despite its high sensitivity and excellent negative predictive value, serum S-100B has low specificity and low positive predictive value, limiting its ability to reduce numbers of CT scans and hospital costs...
  68. doi Stable knockdown of S100A4 suppresses cell migration and metastasis of osteosarcoma
    Masahiko Fujiwara
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Tumour Biol 32:611-22. 2011
    ....
  69. ncbi Schizophrenia-associated neural growth factors in peripheral blood. A review
    Nico J M van Beveren
    Erasmus University Medical Center, Department of Psychiatry, Post Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur Neuropsychopharmacol 16:469-80. 2006
    ....
  70. pmc Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response
    Christopher J Rivard
    Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 282:6644-52. 2007
    ..In summary, we describe the heretofore unrecognized up-regulation of a small calcium-binding protein, both in vitro and in vivo, whose absence profoundly delays osmoadaptation and slows cellular growth under hypertonic conditions...
  71. pmc DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism
    Xuyu Yang
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 71:2916-25. 2011
    ..These results suggest that a novel GAP-independent mechanism contributes to the tumor suppressive activity of DLC1, and highlight the importance and complexity of protein-protein interactions involving DLC1 in certain cancers...
  72. pmc The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography
    Thomas H Charpentier
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
    J Mol Biol 396:1227-43. 2010
    ....
  73. doi Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients
    Inês Esteves Baldeiras
    Neurology Department, Laboratory of Neurochemistry, Coimbra University Hospital, Praceta Mota Pinto, 3000 Coimbra, Portugal
    J Neurol 256:1540-50. 2009
    ..We propose that in cases with a 14-3-3 weak positive result, or in young patients with long disease duration, a second CSF marker would be valuable for the diagnosis of sCJD...
  74. pmc Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis
    David D Tieu
    Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill 60607, USA
    J Allergy Clin Immunol 125:667-75. 2010
    ..Decreased epithelial expression of mRNA for S100A7 (psoriasin) and S100A8/A9 (calprotectin) has been reported in patients with chronic rhinosinusitis (CRS)...
  75. pmc The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS Pathog 7:e1001315. 2011
    ....
  76. pmc Phenothiazines inhibit S100A4 function by inducing protein oligomerization
    Vladimir N Malashkevich
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:8605-10. 2010
    ..Together these studies support a unique mode of inhibition in which phenothiazines disrupt the S100A4/myosin-IIA interaction by sequestering S100A4 via small molecule-induced oligomerization...
  77. ncbi Structure of the negative regulatory domain of p53 bound to S100B(betabeta)
    R R Rustandi
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene Street, Baltimore, Maryland 21201, USA
    Nat Struct Biol 7:570-4. 2000
    ....
  78. doi The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption
    Regine Gläser
    Department of Dermatology, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    J Invest Dermatol 129:641-9. 2009
    ..coli. This indicates that the antimicrobial response in AD is not generally impaired, but greatly differs according to the type of AMP produced by the skin...
  79. pmc S100B inhibits myogenic differentiation and myotube formation in a RAGE-independent manner
    Guglielmo Sorci
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    Mol Cell Biol 23:4870-81. 2003
    ..Our data suggest that S100B might participate in the regulation of muscle development and regeneration by inhibiting crucial steps of the myogenic program in a RAGE-independent manner...
  80. ncbi Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase
    Shibani Bhattacharya
    Department of Biochemistry, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 42:14416-26. 2003
    ..These structural studies, in combination with available biochemical data, have been used to develop a model for calcium-induced activation of NDR kinase by S100B...
  81. pmc SIMPLE: a sequential immunoperoxidase labeling and erasing method
    George Glass
    University of Virginia, UVA Health System, Charlottesville, VA 22908, USA
    J Histochem Cytochem 57:899-905. 2009
    ..SIMPLE is greatly facilitated by the use of a whole-slide scanner, which can capture the results of each sequential stain without any information loss...
  82. pmc Epithelial cell-derived S100 calcium-binding proteins as key mediators in the hallmark acute neutrophil response during Candida vaginitis
    Junko Yano
    Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70119, USA
    Infect Immun 78:5126-37. 2010
    ....
  83. pmc Solution structure of S100A1 bound to the CapZ peptide (TRTK12)
    Nathan T Wright
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA
    J Mol Biol 386:1265-77. 2009
    ..Such comparisons, including those with other S100-target and S100-drug complexes, provide the basis for designing novel small-molecule inhibitors that could be specific for blocking one or more S100-target protein interactions...
  84. ncbi Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation
    Alexandre Semov
    Supratek Pharma Inc, Montreal, Quebec H9S 1A9, Canada
    J Biol Chem 280:20833-41. 2005
    ..Local plasmin formation induced by circulating S100A4 could contribute to tumor-induced angiogenesis and metastasis formation that makes this protein an attractive target for new anti-cancer and anti-angiogenic therapies...
  85. pmc The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma
    Jing Lin
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:27487-98. 2010
    ..Thus, a well known marker for malignant melanoma, S100B, likely contributes to cancer progression by down-regulating the tumor suppressor protein, p53...
  86. pmc Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers
    Jan van Dieck
    Medical Research Council MRC Laboratory of Molecular Biology and MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, United Kingdom
    J Biol Chem 284:13804-11. 2009
    ..We found a stoichiometry of one dimer of S100 bound to a monomer of p53. We discovered that some S100 proteins could also bind to the tetramer...
  87. ncbi A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex
    Kimberly A McClintock
    Department of Biochemistry and McLaughlin Macromolecular Structure Facility, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 278:6251-7. 2003
    ..This would provide a larger, more complex site to interact with full-length target proteins and would account for the promiscuity observed for S100B target protein interactions...
  88. ncbi Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12
    Keith G Inman
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N Greene St, Baltimore, MD 21201, USA
    J Mol Biol 324:1003-14. 2002
    ....
  89. ncbi Insights into S100 target specificity examined by a new interaction between S100A11 and annexin A2
    Anne C Rintala-Dempsey
    Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada N6A 5C1
    Biochemistry 45:14695-705. 2006
    b>S100 proteins are a group of EF-hand calcium-signaling proteins, many of which interact with members of the calcium- and phospholipid-binding annexin family of proteins...
  90. ncbi S100 proteins as cancer biomarkers with focus on S100B in malignant melanoma
    Riikka Harpio
    DiaSorin AB, Stockholm, Sweden
    Clin Biochem 37:512-8. 2004
    ..Decreasing S100B concentrations reflect response to therapy while increasing S100B concentrations indicate tumor progression. Circulating S100B has a role to play in the decision to switch treatment regimens...
  91. ncbi Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene
    Birgitte Grum-Schwensen
    Department of Molecular Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Res 65:3772-80. 2005
    ..Taken together, our results point to a determinative role of host-derived stroma cells expressing S100A4 in tumor progression and metastasis...
  92. ncbi The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1
    Vijay Renigunta
    Institute of Physiology, Marburg University, Deutschhausstr 2, 35037 Marburg, Germany
    Traffic 7:168-81. 2006
    ..Thus, the cytosolic protein p11 may represent a 'retention factor' that causes localization of the channel to the ER...
  93. pmc Prognostic significance of serum S100B protein in high-risk surgically resected melanoma patients participating in Intergroup Trial ECOG 1694
    Ahmad A Tarhini
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Clin Oncol 27:38-44. 2009
    ..We evaluated adjuvant trial E1694 to more precisely define the prognostic significance of serum S100B in patients with high-risk resected melanoma...
  94. ncbi Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations
    A Petzold
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
    Brain 125:1462-73. 2002
    ..They may also be considered in future classifications of multiple sclerosis patients...
  95. ncbi Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation
    H J Huttunen
    Programme of Molecular Neurobiology, Institute of Biotechnology, and the Department of Biosciences, University of Helsinki, Helsinki FIN 00014, Finland
    J Biol Chem 275:40096-105. 2000
    ..b>S100 proteins, especially S100B, are abundantly expressed in the nervous system and are suggested to function as cytokines ..
  96. doi The prognostic value of serum S100B in patients with cutaneous melanoma: a meta-analysis
    Simone Mocellin
    Department of Oncological and Surgical Sciences, University of Padova, Padova, Italy
    Int J Cancer 123:2370-6. 2008
    ..Further investigation focusing on this subset of patients is justified and warranted before S100B can be implemented in the routine clinical management of melanoma...
  97. ncbi The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease?
    Patrizia Morbini
    Dipartimento di Anatomia ed Istologia Patologica, IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Mod Pathol 19:1437-45. 2006
    ....
  98. pmc S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4
    Edda Spiekerkoetter
    Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif 94305 5162, USA
    Circ Res 105:639-47, 13 p following 647. 2009
    ..S100A4/Mts1 is implicated in motility of human pulmonary artery smooth muscle cells (hPASMCs), through an interaction with the RAGE (receptor for advanced glycation end products)...
  99. ncbi Plasma S-100B protein in Chinese patients with schizophrenia: comparison with healthy controls and effect of antipsychotics treatment
    Si Hai Ling
    Beijing Anding Hospital affiliated to Capital University of Medical Sciences, Beijing, China
    J Psychiatr Res 41:36-42. 2007
    ..To examine the possibility that structural damage to the brain may play a role in the pathogenesis of schizophrenia by measuring the level of plasma S-100B, a calcium-binding protein found predominantly in the cytosol of glial cells...
  100. pmc Serum markers to detect metastatic uveal melanoma
    Vivian Barak
    Immunology Laboratory for Tumor Diagnosis, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Anticancer Res 27:1897-900. 2007
    ..S-100beta and melanoma-inhibitory activity (MIA) serum levels are elevated in metastatic cutaneous melanoma. The ability of OPN, S-100beta and MIA serum levels to be used as non-invasive markers for detecting metastatic UM was tested...
  101. ncbi The C-terminal region of S100A4 is important for its metastasis-inducing properties
    Shu Zhang
    Cancer and Polio Research Fund Laboratories, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Oncogene 24:4401-11. 2005
    ..The results suggest that the ability to interact with protein target(s) is important in S100A4-induced metastasis...

Research Grants68

  1. Structure/function studies of S100 proteins and p53
    David Weber; Fiscal Year: 2003
    ..It will be interesting to determine whether these or other p53-binding proteins enhance and/or compete with the S 100B-p53 interaction. ..
  2. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..b>S100 proteins are an important class of protein that are required for calcium signal transduction...
  3. Recanalization Therapies and Markers of Stroke Outcome
    Joseph Broderick; Fiscal Year: 2006
    ..We are confident that these projects will lead to better and safer therapy for patients with acute ischemic stroke...
  4. CLINICAL TRIAL OF HEMATOCRIT STRATEGY IN HEART SURGERY
    Jane Newburger; Fiscal Year: 2004
    ..The inferences reached in this study population should be broadly generalized to infants with other forms of congenital heart disease undergoing early repair and thus should have substantial impact on clinical practice. ..
  5. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    VIRGINIA PICKEL; Fiscal Year: 2001
    ..The findings have implications for understanding mechanisms important for drug abuse, forebrain analgesia, and several motor and sensory disorders in humans. ..
  6. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    VIRGINIA PICKEL; Fiscal Year: 1993
    ..The findings have implications for understanding mechanisms important for drug abuse, forebrain analgesia, and several motor and sensory disorders in humans...
  7. Structure-Function Studies of Annexin I and II
    Hartmut Luecke; Fiscal Year: 2006
    ..5) Co-crystallize annexin with t-PA and solve the structure of this complex after characterizing complex formation in solution. ..
  8. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2007
    ..RAGE ligands include calgranulin/S100 proteins that can exert inflammatory cytokine-like effects...
  9. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..RAGE ligands include calgranulin/S100 proteins that can exert inflammatory cytokine-like effects...
  10. BRAIN OXYGENATION AND METABOLISM
    Anna Pastuszko; Fiscal Year: 2002
    ..3. Polyethylene glycol modified hemoglobin (PEG) can provide significant improvements in oxygen delivery and protection from the metabolic disturbances of CPB. ..
  11. NIAMS: CORT (Psoriasis Center of Research Translation)
    Kevin Cooper; Fiscal Year: 2007
    ..Project 2 is a basic study that determines novel roles for S100 proteins in the pathogenesis of psoriasis, including proof-of-principle testing of S100 and macrophage interplay in ..
  12. Structure/function studies of S100 proteins and p53
    David Weber; Fiscal Year: 2006
    ..It will be interesting to determine whether these or other p53-binding proteins enhance and/or compete with the S 100B-p53 interaction. ..
  13. The Structure and Function of S100 Proteins
    David Weber; Fiscal Year: 2009
    ..but differences in the structures of two proteins in the "hinge" and C-terminal loop explains why these two S100 proteins bind tightly to different protein targets; (ix) together these data enabled us to start developing inhibitors ..
  14. The Structure and Function of S100 Proteins
    David Weber; Fiscal Year: 2009
    ..but differences in the structures of two proteins in the "hinge" and C-terminal loop explains why these two S100 proteins bind tightly to different protein targets; (ix) together these data enabled us to start developing inhibitors ..
  15. S100 PROTEINS: STRUCTURAL BASIS OF FUNCTIONAL PROPERTIES
    Walter Chazin; Fiscal Year: 2007
    ..This proposal is aimed at understanding how S100 proteins modulate the activities of their binding partners and participate in signal transduction pathways, by studying ..