s100 proteins

Summary

Summary: A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF-HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.

Top Publications

  1. ncbi S100 proteins: structure, functions and pathology
    Claus W Heizmann
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Front Biosci 7:d1356-68. 2002
  2. ncbi RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 97:889-901. 1999
  3. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
  4. pmc Functions of S100 proteins
    R Donato
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Mol Med 13:24-57. 2013
  5. ncbi Inflammation-associated S100 proteins: new mechanisms that regulate function
    Jesse Goyette
    Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia
    Amino Acids 41:821-42. 2011
  6. pmc S100A4 and metastasis: a small actor playing many roles
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Am J Pathol 176:528-35. 2010
  7. ncbi S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
    Dirk Foell
    Department of Pediatrics, Institute of Experimental Dermatology, University of Muenster Albert Schweitzer Str 33, Muenster D 48149, Germany
    J Leukoc Biol 81:28-37. 2007
  8. ncbi Regulation of fibrinolysis by S100A10 in vivo
    Alexi P Surette
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS
    Blood 118:3172-81. 2011
  9. ncbi S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)
    Ingo Marenholz
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zürich Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Biochem Biophys Res Commun 322:1111-22. 2004
  10. ncbi Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type
    R Donato
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
    Biochim Biophys Acta 1450:191-231. 1999

Detail Information

Publications342 found, 100 shown here

  1. ncbi S100 proteins: structure, functions and pathology
    Claus W Heizmann
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Front Biosci 7:d1356-68. 2002
    b>S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation...
  2. ncbi RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 97:889-901. 1999
    ..These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury...
  3. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
    ..As a general mechanism, this change in fate highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions...
  4. pmc Functions of S100 proteins
    R Donato
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Mol Med 13:24-57. 2013
    ..b>S100 proteins are only expressed in vertebrates and show cell-specific expression patterns...
  5. ncbi Inflammation-associated S100 proteins: new mechanisms that regulate function
    Jesse Goyette
    Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia
    Amino Acids 41:821-42. 2011
    ..Conversely, S100A8 and S100A9 oxidation and S-nitrosylation may have important protective mechanisms in inflammation...
  6. pmc S100A4 and metastasis: a small actor playing many roles
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Am J Pathol 176:528-35. 2010
    ..In this review, we summarize the evidence connecting S100A4 and cancer metastasis and discuss the mechanisms by which S100A4 promotes tumor progression...
  7. ncbi S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
    Dirk Foell
    Department of Pediatrics, Institute of Experimental Dermatology, University of Muenster Albert Schweitzer Str 33, Muenster D 48149, Germany
    J Leukoc Biol 81:28-37. 2007
    ..One example known for many years to be expressed in cells of myeloid origin are phagocytic S100 proteins, which mediate inflammatory responses and recruit inflammatory cells to sites of tissue damage...
  8. ncbi Regulation of fibrinolysis by S100A10 in vivo
    Alexi P Surette
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS
    Blood 118:3172-81. 2011
    ..These results establish an important role for S100A10 in the regulation of fibrinolysis and angiogenesis in vivo, suggesting S100A10 plays a critical role in endothelial cell function...
  9. ncbi S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)
    Ingo Marenholz
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zürich Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Biochem Biophys Res Commun 322:1111-22. 2004
    ..Despite their small molecular size and their conserved functional domain of two distinct EF-hands, S100 proteins developed a plethora of tissue-specific intra- and extracellular functions...
  10. ncbi Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type
    R Donato
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
    Biochim Biophys Acta 1450:191-231. 1999
    ..Thus, any S100 dimer is suggested to expose two binding surfaces on opposite sides, which renders homodimeric S100 proteins ideal for crossbridging two homologous or heterologous target proteins...
  11. pmc Identification and characterization of a fibroblast marker: FSP1
    F Strutz
    Penn Center for Molecular Studies of Kidney Disease, Department of Medicine, University of Pennsylvania, Philadelphia 19104 6144, USA
    J Cell Biol 130:393-405. 1995
    ..Use of the FSP1 marker, therefore, should further facilitate both the in vivo studies of fibrogenesis and the mapping of cell fate among fibroblasts...
  12. ncbi Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection
    Regine Gläser
    Clinical Research Unit of the Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Nat Immunol 6:57-64. 2005
    ..Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism. Thus, psoriasin may be key to the resistance of skin against E. coli...
  13. ncbi S100B's double life: intracellular regulator and extracellular signal
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Biochim Biophys Acta 1793:1008-22. 2009
    ..Future studies using S100B transgenic and S100B null mice might shed more light on the functional role(s) of the protein...
  14. pmc Seizure-promoting effect of blood-brain barrier disruption
    Nicola Marchi
    Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 48:732-42. 2007
    ..However, evidences also suggest that BBB failure may be an etiological factor contributing to the development of seizures...
  15. ncbi Phagocyte-specific S100 proteins are released from affected mucosa and promote immune responses during inflammatory bowel disease
    D Foell
    Department of Paediatrics, University of Munster, Germany
    J Pathol 216:183-92. 2008
    Phagocyte-derived S100 proteins are endogenous activators of innate immune responses...
  16. ncbi Binding of S100 proteins to RAGE: an update
    Estelle Leclerc
    Department of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA
    Biochim Biophys Acta 1793:993-1007. 2009
    ..However, the exact mechanism is unknown. Among RAGE ligands are members of the S100 protein family. S100 proteins are small calcium binding proteins with high structural homology...
  17. pmc RAGE signaling sustains inflammation and promotes tumor development
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 205:275-85. 2008
    ..We show that RAGE signaling drives the strength and maintenance of an inflammatory reaction during tumor promotion and provide direct genetic evidence for a novel role for RAGE in linking chronic inflammation and cancer...
  18. ncbi Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers
    S S Cross
    Academic Unit of Pathology, Division of Genomic Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Histopathology 46:256-69. 2005
    ..S100A6, S100A8, S100A9 and S100A11 have all been suggested to have potential roles in carcinogenesis and tumour progression but their expression has not been described in a wide range of human tissues and tumours...
  19. pmc S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9
    Mohammad Saleem
    Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:14825-30. 2006
    ..We suggest that S100A4 could be used as a biomarker for CaP progression and a novel therapeutic or chemopreventive target for human CaP treatment...
  20. ncbi S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors
    Mijung Kwon
    Department of Biochemistry, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1, Canada
    Front Biosci 10:300-25. 2005
    ..This review highlights the important part that S100A10 plays in plasmin regulation and the role this protein plays in cancer cell invasiveness and metastasis...
  21. ncbi An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface
    Arunkumar B Deora
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 279:43411-8. 2004
    ..Translocation of annexin 2 to the cell surface dramatically increases tissue plasminogen activator-dependent plasminogen activation potential and may represent a novel stress-induced protein secretion pathway...
  22. ncbi S100-B protein as a screening tool for the early assessment of minor head injury
    Drissa Zongo
    Service des urgences adultes, Hopital Pellegrin, Bordeaux, France
    Ann Emerg Med 59:209-18. 2012
    ..We evaluate S100-B protein measurement as a screening tool in a large population of patients with minor head injury...
  23. ncbi Thrombin induces endothelial cell-surface exposure of the plasminogen receptor annexin 2
    Erica A Peterson
    Canadian Blood Services, R and D Department, 1800 Alta Vista Drive, Ottawa, ON K1G 4J5, Canada
    J Cell Sci 116:2399-408. 2003
    ..These data suggest a novel mechanism that links the coagulation and fibrinolysis pathways by thrombin-mediated feedback...
  24. pmc Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11
    Kai Li He
    Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 283:19192-200. 2008
    ..This mechanism prevents accumulation of free p11 in the endothelial cell and suggests that regulation of tPA-dependent cell surface fibrinolytic activity is precisely tuned to the intracellular level of p11...
  25. ncbi Regulation of S100A10 by the PML-RAR-α oncoprotein
    Paul A O'Connell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, USA
    Blood 117:4095-105. 2011
    ..These experiments show that S100A10 plays a crucial role in the generation of plasmin leading to fibrinolysis, thus providing a link to the clinical hemorrhagic phenotype of APL...
  26. ncbi S100A6 - new facts and features
    Wiesława Leśniak
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 02 093 Warsaw, Poland
    Biochem Biophys Res Commun 390:1087-92. 2009
    ..Additionally, S100A6 might have some extracellular activities. This review presents new facts and features concerning the S100A6 protein...
  27. pmc Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition
    Young Tae Lee
    Departments of Biochemistry and Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
    Biochemistry 47:10921-32. 2008
    ..A series of structure-based SIP mutations showed reduced S100A6 binding affinity, setting the stage for direct functional analysis of S100A6-SIP interactions...
  28. ncbi Mts1 regulates the assembly of nonmuscle myosin-IIA
    Zhong hua Li
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:14258-66. 2003
    ..Altogether, these observations are consistent with mts1 regulating myosin IIA assembly by monomer sequestration and suggest that mts1 regulates cell shape and motility through the modulation of myosin-IIA function...
  29. ncbi The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer
    Ulrike Stein
    Department of Surgery and Surgical Oncology, Robert Rössle Cancer Hospital, Charite Campus Buch, Berlin, Germany
    Gastroenterology 131:1486-500. 2006
    ..Our aim was to elucidate the impact of gain-of-function beta-catenin on the metastasis-associated gene S100A4 in human colon cancer cell lines and tumors...
  30. ncbi S100A4, a mediator of metastasis
    Sarah C Garrett
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 281:677-80. 2006
  31. pmc Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex
    Stan F J van de Graaf
    Department of Cell Physiology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    EMBO J 22:1478-87. 2003
    ..In conclusion, the S100A10-annexin 2 complex plays a crucial role in routing of TRPV5 and TRPV6 to plasma membrane...
  32. pmc S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy
    Steven Greenway
    Division of Cardiovascular Research, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 164:253-62. 2004
    ..The relationship of increased S100A4/Mts1 to pathologically similar lesions in the transgenic mice and patients occurs despite differences in localization (endothelial versus smooth muscle cells)...
  33. ncbi S100A10 regulates plasminogen-dependent macrophage invasion
    Paul A O'Connell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Blood 116:1136-46. 2010
    ..This study establishes a direct involvement of S100A10 in macrophage recruitment in response to inflammatory stimuli...
  34. ncbi S-100B and neuron-specific enolase in serum of mild traumatic brain injury patients. A comparison with health controls
    J R de Kruijk
    Neurology Dept University Hospital Maastricht, The Netherlands
    Acta Neurol Scand 103:175-9. 2001
    ..The aim of the study was to determine whether serum concentrations of neuron-specific enolase (NSE) and S100-B in mild traumatic brain injury (MTBI) patients are higher than in serum of healthy controls...
  35. ncbi Proinflammatory S100 proteins in arthritis and autoimmune disease
    Dirk Foell
    Interdisciplinary Center for Clinical Research, University of Muenster, Muenster, Germany
    Arthritis Rheum 50:3762-71. 2004
  36. pmc Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease
    D Foell
    Department of Paediatrics, University of Munster, Germany
    Gut 52:847-53. 2003
    ..Promising anti-inflammatory effects of blocking agents for RAGE have been reported in murine models of colitis...
  37. ncbi The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
    Sachie Hiratsuka
    Department of Pharmacology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Nat Cell Biol 10:1349-55. 2008
    ..Thus, blocking SAA3-TLR4 function in the pre-metastatic phase could prove to be an effective strategy for the prevention of pulmonary metastasis...
  38. ncbi S100A10/p11: family, friends and functions
    Ursula Rescher
    Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Muenster, Von Esmarch Str 56, 48149 Muenster, Germany
    Pflugers Arch 455:575-82. 2008
    ..In contrast to all other S100 proteins, S100A10 is Ca(2+) insensitive because of amino acid replacements in its Ca(2+)-binding loops that lock the ..
  39. ncbi S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products
    John H Boyd
    Critical Care Research Laboratories, St Paul Hospital, University of British Columbia, Vancouver, Canada
    Circ Res 102:1239-46. 2008
    ..This finding provides a novel mechanistic link between circulating pathogen-associated molecular products and subsequent cardiac dysfunction...
  40. ncbi S100B/RAGE-dependent activation of microglia via NF-kappaB and AP-1 Co-regulation of COX-2 expression by S100B, IL-1beta and TNF-alpha
    Roberta Bianchi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, C P 81 Succ 3, 06122 Perugia, Italy
    Neurobiol Aging 31:665-77. 2010
    ..Given the crucial roles of COX-2, IL-1beta and TNF-alpha in the inflammatory response, we propose that, by engaging RAGE, S100B might play an important role in microglia activation in the course of brain damage...
  41. ncbi The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation
    Olga V Moroz
    Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK
    J Mol Biol 391:536-51. 2009
    ..The role of both zinc and calcium in target binding by S100A12 during host-parasite responses is confirmed by experiments with paramyosin from the tropical parasites Onchocerca volvulus and Brugia malayi...
  42. ncbi Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implications
    Giuseppina Basta
    CNR, Institute of Clinical Physiology, San Cataldo Research Area, Via Moruzzi 1, 56124 Pisa, Italy
    Atherosclerosis 196:9-21. 2008
    ..In the atherosclerotic milieu, three classes of RAGE ligands, i.e., products of non-enzymatic glycoxidation, S100 proteins and amphoterin, appear to drive receptor-mediated cellular activation and potentially, acceleration of ..
  43. ncbi Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study
    Joachim Gerss
    Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany
    Ann Rheum Dis 71:1991-7. 2012
    ..The present study investigated whether patients with JIA at risk of relapse can be identified by biomarkers even if clinical signs of disease activity are absent...
  44. ncbi The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family
    Magdalini Kypriotou
    Laboratory of Cutaneous Biology, Service of Dermatology and Venereology, Beaumont Hospital CHUV, Lausanne, Switzerland
    Exp Dermatol 21:643-9. 2012
    ..Here, we review the EDC genes and the progress in this field...
  45. ncbi Regulation of S100A8 by glucocorticoids
    Kenneth Hsu
    Inflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Immunol 174:2318-26. 2005
    ..Results support the proposal that A8 has anti-inflammatory properties that may be independent of hetero-complex formation with A9 and may also enable localized defense in the absence of overriding deleterious host responses...
  46. pmc S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cells
    Stina Petersson
    Department of Clinical Genetics, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    BMC Cancer 7:205. 2007
    ..IFN-gamma also exerts anti-tumor action in a number of tumor cell types, including breast cancer. We therefore examined the effect of IFN-gamma and STAT-signaling on the psoriasin expression...
  47. pmc Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer
    Ronald Wolf
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    Cancer Lett 277:101-7. 2009
    ..The differential regulation, expression and distribution of hS100A7 and hS100A15 and their reported distinct functions are compelling reasons to discriminate among these proteins in normal breast and breast cancers...
  48. ncbi The role of the annexin A2 heterotetramer in vascular fibrinolysis
    Patricia A Madureira
    Department of Biochemistry and Molecular Biology Dalhousie University, Halifax, NS, USA
    Blood 118:4789-97. 2011
    ..The AIIt mediated colocalization of the plasminogen activators with plasminogen results in the rapid and localized generation of plasmin to the endothelial cell surface, thereby regulating fibrinolysis...
  49. ncbi The role of S100 genes in breast cancer progression
    Eadaoin McKiernan
    Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Tumour Biol 32:441-50. 2011
    ..Based on our findings, we conclude that the different S100 genes play varying roles in breast cancer progression. Specific S100 genes are potential targets for the treatment of basal-type breast cancers...
  50. ncbi Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase
    Masahiro Honda
    Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Yamaguchi, Japan
    J Trauma 69:104-9. 2010
    ..In this study, serum GFAP, S-100B, and neuron-specific enolase (NSE) were compared in the same samples from severe trauma patients to assess their ability to predict abnormalities detectable on head computed tomography (CT)...
  51. ncbi Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli
    Arby Abtin
    Department of Dermatology, Medical University of Vienna, Waehringer Guertal 18 20, 1090 Vienna, Austria
    FASEB J 22:2168-76. 2008
    ..coli supernatant. Taken together, our data demonstrate that bacterial flagellin is essential and sufficient for the induction of S100A7c expression in KCs by E. coli...
  52. ncbi Alterations in 5-HT1B receptor function by p11 in depression-like states
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA
    Science 311:77-80. 2006
    ..p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant...
  53. pmc Evidence for a wide extra-astrocytic distribution of S100B in human brain
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Neurosci 8:2. 2007
    ..However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity...
  54. pmc The metastasis associated protein S100A4: role in tumour progression and metastasis
    D M Helfman
    Department of Cell Biology and Anatomy, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    Br J Cancer 92:1955-8. 2005
    ..Below we discuss its biochemical properties and possible cellular functions in metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation...
  55. ncbi Pathologies involving the S100 proteins and RAGE
    C W Heizmann
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Switzerland
    Subcell Biochem 45:93-138. 2007
    The S100 proteins are exclusively expressed in vertebrates and are the largest subgroup within the superfamily of EF-hand Ca2(+)-binding proteins Generally, S100 proteins are organized as tight homodimers (some as heterodimers)...
  56. ncbi S100 proteins in the epidermis
    Richard L Eckert
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Invest Dermatol 123:23-33. 2004
    The S100 proteins comprise a family of 21 low molecular weight (9-13 kDa) proteins that are characterized by the presence of two calcium-binding EF-hand motifs...
  57. ncbi Intracellular and extracellular roles of S100 proteins
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, 06122 Perugia, Italy
    Microsc Res Tech 60:540-51. 2003
    ..Structural information indicates that most of S100 proteins exist in the form of antiparallelly packed homodimers (in some cases heterodimers), capable of functionally ..
  58. pmc S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways
    Mohd W Nasser
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 72:604-15. 2012
    ..In summary, our work used a powerful new model system to show that S100A7 enhances breast tumor growth and metastasis by activating proinflammatory and metastatic pathways...
  59. ncbi S100B protein in neurodegenerative disorders
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Clin Chem Lab Med 49:409-24. 2011
    ..Moreover, there is no consistent evidence for a correlation between disease severity and concentrations of S100B in CSF or serum. Therefore, S100B has limited usefulness for monitoring disease progression...
  60. ncbi RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Mol Med 7:711-24. 2007
    ..b>S100 proteins are expressed in vertebrates exclusively, display a cell-specific distribution, and regulate a large variety ..
  61. ncbi Silencing of the annexin II gene down-regulates the levels of S100A10, c-Myc, and plasmin and inhibits breast cancer cell proliferation and invasion
    Jian Zhang
    Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Saudi Med J 31:374-81. 2010
    ..To explore the roles of annexin II in breast cancer progression, and to study the effect of annexin II on breast cancer cell proliferation and invasion...
  62. ncbi Human S100A12: a novel key player in inflammation?
    Jens Pietzsch
    Department of Radiopharmaceutical Biology, Institute of Radiopharmacy, Research Center Dresden Rossendorf, POB 51 01 19, 01314 Dresden, Germany
    Amino Acids 36:381-9. 2009
    ..Recent clinical evidence suggests a high potential of S100A12 as a sensitive and specific diagnostic marker of localized inflammatory processes...
  63. ncbi Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury
    Jurgen Harder
    Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Invest Dermatol 130:1355-64. 2010
    ..Thus, a disturbed skin barrier may trigger AMP induction in AD and psoriasis. The functional role of AMP in AD, especially with regard to the control of S. aureus colonization, needs further analysis...
  64. ncbi The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes
    I S Thorey
    Institute of Cell Biology, , , , Switzerland
    J Biol Chem 276:35818-25. 2001
    ....
  65. ncbi Nuclear S100A4 is a novel prognostic marker in colorectal cancer
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Eur J Cancer 46:2919-25. 2010
    ....
  66. pmc S100A7 and the progression of breast cancer
    Ethan D Emberley
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res 6:153-9. 2004
    ..Subsequent studies have started to describe a functional role for these S100 proteins as well as their mechanism of action and the biochemical pathways they modify...
  67. ncbi The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome
    H Worthmann
    Department of Neurology, Medical School of Hannover, Hannover, Germany
    Cerebrovasc Dis 30:85-92. 2010
    ..The present study aimed to clarify the temporal dynamics of discrete inflammatory markers/mediators for future mechanism-targeting anti-inflammatory strategies in ischemic brain damage...
  68. pmc p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1
    Christophe Girard
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    EMBO J 21:4439-48. 2002
    ..p11 association with the TASK-1 channel masks an endoplasmic reticulum retention signal identified as Lys-Arg-Arg that precedes the Ser-Ser-Val sequence...
  69. ncbi Effects of head and extracranial injuries on serum protein S100B levels in trauma patients
    Olli Savola
    Department of Neurology, Oulu University Hospital, Oulu, Finland
    J Trauma 56:1229-34; discussion 1234. 2004
    ..Serum protein S100B determinations have been recently suggested as markers of traumatic brain injury. However, little is known about the effects of extracranial injuries on S100B levels in trauma patients...
  70. ncbi High-level expression of S100A4 correlates with lymph node metastasis and poor prognosis in patients with gastric cancer
    Yuan Yu Wang
    Wenzhou Medical College, Wenzhou, Zhejiang, People s Republic of China
    Ann Surg Oncol 17:89-97. 2010
    ..The present study investigated the clinical significance of S100 calcium binding protein A4 in the development, progression, and metastasis of gastric cancer...
  71. ncbi Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury
    P E Vos
    Department of Neurology, University Medical Centre Nijmegen, The Netherlands
    Neurology 62:1303-10. 2004
    ..To study the ability of glial (glial fibrillary acidic protein [GFAP] and S100b) and neuronal (neuron specific enolase [NSE]) protein levels in peripheral blood to predict outcome after severe traumatic brain injury...
  72. ncbi Spatial and temporal expression of S100B in cells of oligodendrocyte lineage
    S Hachem
    Unité INSERM 469, Centre CNRS INSERM de Pharmacologie et d Endocrinologie, Montpellier Cedex, France
    Glia 51:81-97. 2005
    ....
  73. pmc Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function
    Olga V Moroz
    Wolfson Centre for Age Related Diseases, School of Biomedical and Health Sciences, King s College London, London, UK
    BMC Biochem 10:11. 2009
    ..S100A12 is an important factor in host/parasite defenses and in the inflammatory response. Like several other S100 proteins, it binds zinc and copper in addition to calcium...
  74. ncbi S100A4 mRNA is a diagnostic and prognostic marker in pancreatic carcinoma
    Naoki Ikenaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    J Gastrointest Surg 13:1852-8. 2009
    ..The aim of this study is to evaluate the clinical significance of S100A4 mRNA expression in pancreatic cancer...
  75. ncbi Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia
    Anya Pedersen
    University Medical Faculty, Department of Psychiatry, 48149 Munster, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 32:1789-92. 2008
    ..The findings support the hypothesis that astrocyte activation might contribute to the development of cognitive dysfunction in schizophrenia...
  76. pmc S100A expression in normal corneal-limbal epithelial cells and ocular surface squamous cell carcinoma tissue
    Jing Li
    Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University, China
    Mol Vis 17:2263-71. 2011
    ..To study the expression and cellular distribution of multiple S100A genes and proteins in normal corneal-limbal epithelium and ocular surface squamous cell carcinoma (SCC) tissue...
  77. ncbi S100B and NSE serum levels in obstructive sleep apnea syndrome
    Carla W Braga
    Departamento de Bioquimica, Rua Ramiro Barcelos 2600 anexo, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
    Sleep Med 7:431-5. 2006
    ..In the present work we measured the serum levels of S100B and NSE in order to evaluate the deleterious effects of OSAS to the brain...
  78. ncbi S100B gene polymorphisms predict prefrontal spatial function in both schizophrenia patients and healthy individuals
    Jinguo Zhai
    School of Mental Health, Jining Medical University, 45 Jianshe South Road, Jining 272013, Shandong Province, PR China
    Schizophr Res 134:89-94. 2012
    ..No SNP was associated with prefontal functions in the verbal domain (all Ps >0.05). These results extend our previous study and further confirm the important roles of the S100B gene in spatial abilities...
  79. ncbi S100A7, S100A10, and S100A11 are transglutaminase substrates
    M Ruse
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106 4970, USA
    Biochemistry 40:3167-73. 2001
    b>S100 proteins are a family of 10-14 kDa EF-hand-containing calcium binding proteins that function to transmit calcium-dependent cell regulatory signals...
  80. ncbi Potential inflammatory biomarkers in Alzheimer's disease
    Robert E Mrak
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Alzheimers Dis 8:369-75. 2005
    ....
  81. ncbi The metastasis associated protein S100A4: a potential novel link to inflammation and consequent aggressive behaviour of rheumatoid arthritis synovial fibroblasts
    L Oslejsková
    Institute of Rheumatology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Ann Rheum Dis 67:1499-504. 2008
    ....
  82. pmc S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation
    Hugo M Botelho
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, 2781 901 Oeiras, Portugal
    J Biol Chem 287:42233-42. 2012
    ..Following recent reports of amyloid formation by S100 proteins, we investigated the aggregation properties of S100A6...
  83. ncbi Risk variants in the S100B gene, associated with elevated S100B levels, are also associated with visuospatial disability of schizophrenia
    Jinguo Zhai
    School of Mental Health, Jining Medical University, Jining 272013, Shandong Province, People s Republic of China
    Behav Brain Res 217:363-8. 2011
    ..These results implicate a role for S100B gene polymorphisms in the cognitive functions of schizophrenia patients and encourage further investigation into spatial disability as an endophenotype of schizophrenia...
  84. ncbi Fecal S100A12: a novel noninvasive marker in children with Crohn's disease
    Naomi S H de Jong
    School of Women s and Children s Health, University of New South Wales, Australia
    Inflamm Bowel Dis 12:566-72. 2006
    ....
  85. ncbi S100A4: a common mediator of epithelial-mesenchymal transition, fibrosis and regeneration in diseases?
    Mikael Schneider
    Laboratory of Molecular and Cellular Cardiology, Department of Biochemistry, Pharmacology, and Genetics, University Hospital of Odense, 29, Sdr Boulevard, DK 5000, Odense C, Denmark
    J Mol Med (Berl) 86:507-22. 2008
    ....
  86. ncbi Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer
    Nikhil A Gokhale
    Department of Chemistry, University of Illinois, Chicago, Illinois 60607 7061, USA
    J Biol Chem 280:42831-40. 2005
    ..Collectively, these studies elucidate the structural determinant of the PtdIns(4,5)P2 selectivity of A2t and suggest that A2t may be involved in the regulation of PtdIns(4,5)P2 clustering in the cell...
  87. ncbi BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene
    Richard D Kennedy
    Cancer Research Centre, Queen s University Belfast, Belfast City Hospital, Belfast, United Kingdom
    Cancer Res 65:10265-72. 2005
    ..Therefore, we identified a novel transcriptional mechanism that is likely to contribute to BRCA1-mediated resistance to etoposide...
  88. ncbi RAGE: a multi-ligand receptor unveiling novel insights in health and disease
    P Alexiou
    Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Greece
    Curr Med Chem 17:2232-52. 2010
    ..Additionally, its potential as an attractive pharmacotherapeutic target will be explored by pointing out the pharmacotherapeutic agents that have been developed for RAGE blockade...
  89. pmc Carboxylated N-glycans on RAGE promote S100A12 binding and signaling
    Geetha Srikrishna
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Cell Biochem 110:645-59. 2010
    ..These results demonstrate that carboxylated N-glycans on RAGE enhance binding potential and promote receptor clustering and subsequent signaling events following oligomeric S100A12 binding...
  90. ncbi Overexpression of protein S100A4 is independently associated with overall survival in stage C colonic cancer but only in cytoplasm at the advancing tumour front
    P S S Kho
    Department of Medicine, Concord Hospital, Sydney, New South Wales, Australia
    Int J Colorectal Dis 27:1409-17. 2012
    ..This study investigated the association between S100A4 and overall survival and other clinicopathological features in patients with stage C colonic cancer...
  91. ncbi Brain- and heart-type fatty acid-binding proteins in the brain: tissue distribution and clinical utility
    Maurice M A L Pelsers
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Clin Chem 50:1568-75. 2004
    ..We investigated the tissue distribution of brain- and heart-type fatty acid-binding proteins (B-FABP and H-FABP) in segments of the human brain and the potential of either protein to serve as plasma marker for diagnosis of brain injury...
  92. pmc The 1.5 Å crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding
    HaJeung Park
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:40762-70. 2010
    ..of the pattern recognition receptor, RAGE with key ligands such as advanced glycation end products (AGE), S100 proteins, amyloid β, and HMGB1 has been linked to diabetic complications, inflammatory and neurodegenerative disorders,..
  93. ncbi S100B in schizophrenia: an update
    Matthias Rothermundt
    Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
    Gen Physiol Biophys 28:F76-81. 2009
    ..These findings suggest that the activation of astrocytes might be an important pathogenic factor for the development of schizophrenia...
  94. ncbi S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid
    Hye Sook Min
    Department of Pathology, National Cancer Center, Goyang, Gyenggi, Korea
    Mod Pathol 21:748-55. 2008
    ..In conclusion, S100A4 expression in papillary microcarcinomas may indicate the presence of nodal metastasis. Thus, S100A4 immunohistochemistry may be valuable for predicting metastatic potential in papillary microcarcinomas...
  95. pmc Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response
    Christopher J Rivard
    Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 282:6644-52. 2007
    ..In summary, we describe the heretofore unrecognized up-regulation of a small calcium-binding protein, both in vitro and in vivo, whose absence profoundly delays osmoadaptation and slows cellular growth under hypertonic conditions...
  96. ncbi Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 26:171-9. 2011
    ..The potential of neural-derived IgG autoantibodies as part of a biomarker panel for the diagnosis of Lewy body-associated dementias should be further evaluated...
  97. ncbi Phenotypic and functional characteristics of mesenchymal stem cells differentiated along a Schwann cell lineage
    Jenny Caddick
    Blond McIndoe Research Laboratories, University of Manchester, Manchester, United Kingdom
    Glia 54:840-9. 2006
    ..These findings support the assertion that MSCs can be differentiated into cells that are Schwann cell-like in terms of both phenotype and function...
  98. ncbi S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes
    Mikael Schneider
    The Laboratory of Molecular and Cellular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Medicine B, H S Rigshospitalet, Copenhagen University Hospital, Denmark
    Cardiovasc Res 75:40-50. 2007
    ..We therefore hypothesized that S100A4 could play a supportive role in the injured heart...
  99. ncbi The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury
    Jane Topolovec-Vranic
    Trauma and Neurosurgery Program, St Michael s Hospital, Toronto, Canada
    J Trauma 71:S478-86. 2011
    ..To determine, using a civilian model of mild traumatic brain injury (TBI), the added value of biomarker sampling upon prognostication of outcome at 1 week and 6 weeks postinjury...
  100. pmc DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism
    Xuyu Yang
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 71:2916-25. 2011
    ..These results suggest that a novel GAP-independent mechanism contributes to the tumor suppressive activity of DLC1, and highlight the importance and complexity of protein-protein interactions involving DLC1 in certain cancers...
  101. ncbi Can low serum levels of S100B predict normal CT findings after minor head injury in adults?: an evidence-based review and meta-analysis
    Johan Undén
    Department of Anaesthesia and Intensive Care, Halmstad Regional Hospital, Halmstad, Sweden
    J Head Trauma Rehabil 25:228-40. 2010
    ..To determine whether low levels of S100B in serum can predict normal computed tomography (CT) findings after minor head injury (MHI) in adults...

Research Grants62

  1. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..b>S100 proteins are an important class of protein that are required for calcium signal transduction...
  2. DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm Birth
    Irina A Buhimschi; Fiscal Year: 2013
    ..This body of knowledge, corroborated with the evidence that HMGB1 and S100 proteins are putative RAGE ligands, has led us to propose an active role for the DAMP- RAGE axis in inducing antenatal ..
  3. 950 MHz NMR Spectrometer with Cryogenic Probe
    DAVID JOSEPH WEBER; Fiscal Year: 2010
    ..Dr. David J. Weber (UMB), Structure/function and inhibition of protein-protein complexes involving S100 proteins;2. Dr. Michael Summers (UMBC) NMR studies of retroviral genome packaging;3. Dr...
  4. Invivo role of S100A4 in OA pathophysiology
    Raghunatha R Yammani; Fiscal Year: 2013
    ..b>S100 proteins are low molecular weight, acidic, calcium-binding proteins that play an important role in various cellular ..
  5. Epithelial Cell-Derived IL-1-alpha as a Novel Danger Signal in IBD Pathogenesis
    Eleni Stylianou; Fiscal Year: 2013
    ..protein 1 (HMGB1), nucleic acids, uric acid, degradation products of the extracellular matrix, calcium-binding S100 proteins, and many others...
  6. Protein dynamics of calcium-S100A5 in the presence and absence of target peptide
    Melissa A Liriano; Fiscal Year: 2012
    ..Aberrant levels ofthese signaling molecules have also been associated with various forms of cancer. Some S100 proteins have been found to directly promote the advancement of certain tumors via protein-protein interactions...
  7. Targeting RAGE/Abeta interaction with single chain monoclonal antibodies
    Estelle Leclerc; Fiscal Year: 2012
    ..We will then test the ability of these antibodies to block cell death triggered by the engagement of RAGE by distinct b amyloid oligomeric forms. ..
  8. S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancer
    GEETHA K SRIKRISHNA; Fiscal Year: 2010
    ..tissues;and Generate bone marrow chimeras to study if S100 deficient mice are more prone to tumors when S100 proteins are restored...
  9. CLINICAL TRIAL OF HEMATOCRIT STRATEGY IN HEART SURGERY
    Jane Newburger; Fiscal Year: 2004
    ..The inferences reached in this study population should be broadly generalized to infants with other forms of congenital heart disease undergoing early repair and thus should have substantial impact on clinical practice. ..
  10. Structure-Function Studies of Annexin I and II
    Hartmut Luecke; Fiscal Year: 2006
    ..5) Co-crystallize annexin with t-PA and solve the structure of this complex after characterizing complex formation in solution. ..
  11. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..RAGE ligands include calgranulin/S100 proteins that can exert inflammatory cytokine-like effects...
  12. Structure of calcyclin binding protein-S100A6 complex
    Walter Chazin; Fiscal Year: 2004
    DESCRIPTION (provided by applicant) S100 proteins constitute a major subfamily of EF-hand Ca2+-binding proteins that are characterized by cell type-specific expression and unusually high abundance in a variety of disease states, ..
  13. The Structure and Function of S100 Proteins
    DAVID JOSEPH WEBER; Fiscal Year: 2010
    ..but differences in the structures of two proteins in the "hinge" and C-terminal loop explains why these two S100 proteins bind tightly to different protein targets;(ix) together these data enabled us to start developing inhibitors ..
  14. DECIPHERING THE CELLULAR FUNCTION OF ALDOLASE
    DEAN TOLAN; Fiscal Year: 2003
    ..to bind to several important intracellular binding targets, such as F-actin and the calcium-binding S100 proteins. Evolutionary comparisons have revealed isozyme-specific residues (ISRs) and this proposal will determine ..
  15. ATOMIC STRUCTURE OF SMOOTH MUSCLE CALDESMON
    Roberto Dominguez; Fiscal Year: 2004
    ..including binding to actin, tropomyosin, and Ca2+-dependent regulatory proteins (such as calmodulin and S100 proteins)...
  16. 600 MHz NMR Spectrometer Console
    David Weber; Fiscal Year: 2007
    ..Dr. David J. Weber (PI), Structure/function and drug design for S100 proteins; 2. Dr. Lindsay Black, Structure/function studies of the phage IPI protein; 3. Dr...
  17. ROLES OF PHOSPHOLIPID AND CA2+ IN BRAIN
    JYH FA KUO; Fiscal Year: 1990
    ..It is hoped that the proposal will produce new knowledge regarding regulation of brain biology and pathology by phospholipid, Ca2+ and S-100 protein via protein phosphorylation reaction...
  18. Drug Discovery Academic Research Experience(DARE)
    Linda Van Eldik; Fiscal Year: 2006
    ....
  19. Detecting Axonal Damage After Mild Traumatic Brain Injury
    Jeffrey Bazarian; Fiscal Year: 2009
    ....
  20. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  21. Fine Needle Aspiration Biopsy(FNAB) Needle Device
    Vinod Shidham; Fiscal Year: 2002
    ..Apart from the worldwide market, the potential market in United States alone should exceed $1,500,000 per year. ..
  22. Comparative DNA Microarray Analysis of Brain Tumors
    Daniel Brat; Fiscal Year: 2006
    ....
  23. Epidemiology of Traumatic Brain Injury
    Jeffrey Bazarian; Fiscal Year: 2005
    ....
  24. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    ..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
  25. Neuroinflammation in Alzheimers Disease Murine Models
    Jeffrey Craft; Fiscal Year: 2007
    ..These mice may then be treated with test compounds to identify and/or verify the neuroinflammatory pathways through which these agents exert their effects. [unreadable] [unreadable]..
  26. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel J Brat; Fiscal Year: 2010
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
  27. MOLECULAR BASIS OF LOCAL ANESTHESIA
    Walter Chazin; Fiscal Year: 2008
    ....
  28. Secretomes captured in vivo via ultrafiltration probes
    Chun Ming Huang; Fiscal Year: 2008
    ..We believe that using CUF probes/Mass spectrometry will be a powerful tool which can be applied to other animal models and other human diseases. [unreadable] [unreadable] [unreadable]..
  29. Ultrasensitive FACTT assays for serum biomarkers
    Xiaowei Xu; Fiscal Year: 2008
    ..unreadable] [unreadable] ASSESSMENT: [unreadable] [unreadable] [unreadable]..
  30. Evaluation of pH Dependent Neuroprotectants in SAH Model
    Daniel Laskowitz; Fiscal Year: 2008
    ..In this project promising new drugs that may one day protect brain tissue from damage caused by SAH and stroke will be tested in an animal model of ischemia. [unreadable] [unreadable] [unreadable]..
  31. PKC and Cellular Signaling in the Suicide Brain
    Ghanshyam Pandey; Fiscal Year: 2009
    ..This knowledge may aid in developing better therapeutic strategies for the treatment of suicidal behavior. ..
  32. Axon Regeneration after Spinal Cord Injury in Mice
    Oswald Steward; Fiscal Year: 2009
    ..Together, these studies will provide a critical data base regarding the growth capacity of cortico-spinal tract axons in mice, which will be essential for future studies involving genetically modified mice. ..
  33. Amphiregulin in Psoriatic Epidermal Hyperplasia
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..
  34. Epigenetics of fetal alcohol syndrome
    Feng Zhou; Fiscal Year: 2009
    ..The effect of these epigenetic key genes will be confirmed in the in vivo model exposed to alcohol vapor chamber with alcohol exposure pattern and paradigms similar to the whole embryonic culture. ..
  35. PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia Subjects
    Ghanshyam N Pandey; Fiscal Year: 2011
    ..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
  36. S100 PROTEINS: STRUCTURAL BASIS OF FUNCTIONAL PROPERTIES
    Walter Chazin; Fiscal Year: 2009
    ..This proposal is aimed at understanding how S100 proteins modulate the activities of their binding partners and participate in signal transduction pathways, by studying ..
  37. FGF in sensory system development
    OLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010
    ..Moreover, a better understanding of the molecular pathways regulating normal development will be critical for rational strategies for hair cell replacement and regeneration in adult onset deafness. ..
  38. MATERNAL ALCOHOLISM AND CNS DEVELOPMENT IN OFFSPRING
    MARY DRUSE MANTEUFFEL; Fiscal Year: 2007
    ..Analyses will include western blot analyses, real-time quantitative RT-PCR, fluorescence and light microscopy, immunohistochemistry, and enzyme assays. ..
  39. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
  40. ApoE-mimetic peptides protect against brain injury
    Daniel Laskowitz; Fiscal Year: 2004
    ..We will use this system to investigate possible pharmacogenomic interactions between the therapeutic apoE peptide and the humanized apoE background in the targeted replacement mice. ..
  41. ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS
    Feng Zhou; Fiscal Year: 2003
    ....
  42. BHLH FACTOR IN DIABETES & PANCREAS DEVELOPMENT
    DEBRA BRAMBLETT; Fiscal Year: 2003
    ..The BETA4 knockout will be a mouse model system for the study of aspects of pancreas development and possibly pancreatic disease. ..
  43. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2004
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
  44. MICROGLIAL NEURON SPECIFIC TOXIN
    Daniel Laskowitz; Fiscal Year: 2003
    ..Conversely, drugs that show promise against AD and PD will be examined in this model system to see if they inhibit the production or action of the neuron- specific toxin. ..
  45. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..abstract_text> ..
  46. APOLIPOPROTEIN E EFFECT ON THE CNS IMMUNE RESPONSE
    Daniel Laskowitz; Fiscal Year: 2002
    ..abstract_text> ..
  47. GENETIC APPROACH TO CNS REGENERATION RESEARCH
    Oswald Steward; Fiscal Year: 2001
    ....
  48. Proteomics: The Next Grand Biological Challenge
    Walter Chazin; Fiscal Year: 2002
    ..A concentrated effort will be made to attract ethnic minorities, women and persons with disabilities as participants, organizers, and speakers. ..
  49. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
    ..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
  50. CYTOKINES, NEURODEGENERATION AND DOWN'S SYNDROME
    Sue Griffin; Fiscal Year: 2004
    ..Accomplishment of our aims will elucidate the pathogenic mechanisms underlying the cognitive decline apparent at middle age in Down's patients and provide targets for possible therapeutic intervention. ..
  51. Alcohol and SIV neuroinvasion in vivo and in vitro
    ANDREW MACLEAN; Fiscal Year: 2004
    ..This proposal combines in vitro and in vivo models and expertise in the neuropathogenesis of AIDS of the SIV macaque model with expertise in the biological effects of alcohol abuse. ..
  52. Bevacizumab and radiation therapy for sarcomas
    Sam Yoon; Fiscal Year: 2007
    ..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. [unreadable] [unreadable] [unreadable]..
  53. Focal Brain Ischemia in the TNF-alpha-Transgenic Rat
    L Pettigrew; Fiscal Year: 2007
    ....
  54. New Molecular Targets in Pulmonary Fibrosis
    Naftali Kaminski; Fiscal Year: 2006
    ..This will be done by assessing the effect of in-vitro inhibiting or inducing the expression of validated candidate molecules on ECM production and cytokine and growth factor secretion. ..
  55. BIOCHEMICAL MECHANISMS OF BRAIN INJURY
    EARL ELLIS; Fiscal Year: 2006
    ..Aims and Methods: Our approach will use astrocytes and neuronal plus glial cultures, Fura-2 measurement. ..
  56. Trigeminal Neuropathic Pain Mechanisms
    Michael Henry; Fiscal Year: 2006
    ..Identification of specific sodium channel alterations after injury may help develop more selective treatments for neuropathic pain. ..
  57. Rap 1-Mediated Protein Transport in Oral Cancer
    NISHA D SILVA; Fiscal Year: 2006
    ..The significance of this research is that it explores an important and novel mechanism for nucleocytoplasmic transport of pro-proliferative proteins in oral cancer, thereby identifying novel treatment targets. [unreadable] [unreadable]..
  58. Proteomics of Idiopathic Pulmonary Fibrosis
    Naftali Kaminski; Fiscal Year: 2006
    ..We assume that this approach will provide us with new molecular targets for therapeutic intervention in pulmonary fibrosis. ..
  59. Proposed Role for Neuronal Serotonin N-acetyltransferase
    Hari Manev; Fiscal Year: 2006
    ..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
  60. The Role of RAGE and EAE
    Shi Du Yan; Fiscal Year: 2005
    ....
  61. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..abstract_text> ..