nerve tissue proteins


Top Publications

  1. ncbi Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    Taichi Hara
    Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
    Nature 441:885-9. 2006
  2. ncbi Loss of autophagy in the central nervous system causes neurodegeneration in mice
    Masaaki Komatsu
    Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Nature 441:880-4. 2006
  3. ncbi Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    Brinda Ravikumar
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 36:585-95. 2004
  4. pmc Membrane fusion: grappling with SNARE and SM proteins
    Thomas C Sudhof
    Department of Cellular and Molecular Physiology, Stanford University, Palo Alto, CA 94304, USA
    Science 323:474-7. 2009
  5. pmc Neuroligins and neurexins link synaptic function to cognitive disease
    Thomas C Sudhof
    Neuroscience Institute, Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road B249, Palo Alto, California 94304, USA
    Nature 455:903-11. 2008
  6. ncbi Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    L Mangiarini
    Division of Medical and Molecular Genetics, UMDS, Guy s Hospital, London, United Kingdom
    Cell 87:493-506. 1996
  7. ncbi In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    Qiao Zhou
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 455:627-32. 2008
  8. pmc miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
    Li Chun Cheng
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Nat Neurosci 12:399-408. 2009
  9. pmc Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression
    Dongbo Yu
    Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 9041, USA
    Cell 150:895-908. 2012
  10. ncbi Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    M Difiglia
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:1990-3. 1997

Detail Information

Publications393 found, 100 shown here

  1. ncbi Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    Taichi Hara
    Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
    Nature 441:885-9. 2006
  2. ncbi Loss of autophagy in the central nervous system causes neurodegeneration in mice
    Masaaki Komatsu
    Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Nature 441:880-4. 2006
    ..Our results indicate that autophagy is essential for the survival of neural cells, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies...
  3. ncbi Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    Brinda Ravikumar
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 36:585-95. 2004
    ..Our data provide proof-of-principle for the potential of inducing autophagy to treat Huntington disease...
  4. pmc Membrane fusion: grappling with SNARE and SM proteins
    Thomas C Sudhof
    Department of Cellular and Molecular Physiology, Stanford University, Palo Alto, CA 94304, USA
    Science 323:474-7. 2009
  5. pmc Neuroligins and neurexins link synaptic function to cognitive disease
    Thomas C Sudhof
    Neuroscience Institute, Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road B249, Palo Alto, California 94304, USA
    Nature 455:903-11. 2008
    ..In humans, alterations in genes encoding neurexins or neuroligins have recently been implicated in autism and other cognitive diseases, linking synaptic cell adhesion to cognition and its disorders...
  6. ncbi Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    L Mangiarini
    Division of Medical and Molecular Genetics, UMDS, Guy s Hospital, London, United Kingdom
    Cell 87:493-506. 1996
    ..This transgenic model will greatly assist in an eventual understanding of the molecular pathology of HD and may open the way to the testing of intervention strategies...
  7. ncbi In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    Qiao Zhou
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 455:627-32. 2008
    ..This study provides an example of cellular reprogramming using defined factors in an adult organ and suggests a general paradigm for directing cell reprogramming without reversion to a pluripotent stem cell state...
  8. pmc miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
    Li Chun Cheng
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Nat Neurosci 12:399-408. 2009
    ..Sox9 overexpression abolished neuronal differentiation, whereas Sox9 knockdown led to increased neuron formation. Thus miR-124-mediated repression of Sox9 is important for progression along the SVZ stem cell lineage to neurons...
  9. pmc Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression
    Dongbo Yu
    Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 9041, USA
    Cell 150:895-908. 2012
    ..These data demonstrate that chemically modified ss-siRNAs function through the RNAi pathway and provide allele-selective compounds for clinical development...
  10. ncbi Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    M Difiglia
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:1990-3. 1997
    ..Ubiquitin was also found in NIIs and DNs, which suggests that abnormal huntingtin is targeted for proteolysis but is resistant to removal. The aggregation of mutant huntingtin may be part of the pathogenic mechanism in HD...
  11. pmc The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease
    Amy N Packer
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 28:14341-6. 2008
    ..These data provide evidence for a double negative feedback loop between the REST silencing complex and the miRNAs it regulates...
  12. ncbi Molecular mechanisms and potential therapeutical targets in Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milan, Italy
    Physiol Rev 90:905-81. 2010
  13. pmc Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
    Christopher I Amos
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 40:616-22. 2008
    ..Haplotype analysis was consistent with there being a single risk variant in this region. We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk...
  14. ncbi The roles of intracellular protein-degradation pathways in neurodegeneration
    David C Rubinsztein
    Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY
    Nature 443:780-6. 2006
    ..However, enhancing macroautophagy with drugs such as rapamycin could offer a tractable therapeutic strategy for a number of these diseases...
  15. ncbi A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
    Shiaoching Gong
    GENSAT Project, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 260, New York 10021, USA
    Nature 425:917-25. 2003
    ..The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community...
  16. pmc The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing
    Eugene V Makeyev
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Cell 27:435-48. 2007
    ..Thus, miR-124 promotes NS development, at least in part by regulating an intricate network of NS-specific alternative splicing...
  17. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
    ..Together, these results implicate DISC1 in GSK3beta/beta-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders...
  18. ncbi The molecular motor toolbox for intracellular transport
    Ronald D Vale
    Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 112:467-80. 2003
    ..Remarkably, fungi, parasites, plants, and animals have distinct subsets of Toolbox motors in their genomes, suggesting an underlying diversity of strategies for intracellular transport...
  19. ncbi NeuN, a neuronal specific nuclear protein in vertebrates
    R J Mullen
    Department of Anatomy, University of Utah School of Medicine, Salt Lake City 84132
    Development 116:201-11. 1992
    ..This mAb and the protein recognized by it serve as an excellent marker for neurons in the central and peripheral nervous systems in both the embryo and adult, and the protein may be important in the determination of neuronal phenotype...
  20. ncbi Huntington's disease: from molecular pathogenesis to clinical treatment
    Christopher A Ross
    Departments of Psychiatry, Neurology, Pharmacology, and Neuroscience, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet Neurol 10:83-98. 2011
    ..Thus, Huntington's disease is also emerging as a model for strategies to develop therapeutic interventions, not only to slow progression of manifest disease but also to delay, or ideally prevent, its onset...
  21. pmc Linking neurodevelopmental and synaptic theories of mental illness through DISC1
    Nicholas J Brandon
    Pfizer Neuroscience, Groton, Connecticut 06437, USA
    Nat Rev Neurosci 12:707-22. 2011
  22. pmc Induction of human neuronal cells by defined transcription factors
    Zhiping P Pang
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA
    Nature 476:220-3. 2011
    ..These methods may facilitate robust generation of patient-specific human neurons for in vitro disease modelling or future applications in regenerative medicine...
  23. ncbi Identification and characterization of a spinal muscular atrophy-determining gene
    S Lefebvre
    Unite de Recherches sur les Handicaps Genetiques de l Enfant, Institut National de la Sante et de la Recherche Medicale, Institut Necker, Hopital des Enfants Malades, Paris, France
    Cell 80:155-65. 1995
    ..These data suggest that this gene, termed the survival motor neuron (SMN) gene, is an SMA-determining gene...
  24. pmc Coupling of the nucleus and cytoplasm: role of the LINC complex
    Melissa Crisp
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610
    J Cell Biol 172:41-53. 2006
    ..2005), support a model in which Sun proteins tether nesprins in the ONM via interactions spanning the PNS. In this way, Sun proteins and nesprins form a complex that links the nucleoskeleton and cytoskeleton (the LINC complex)...
  25. ncbi Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    Pascale N Lacor
    Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, USA5
    J Neurosci 24:10191-200. 2004
    ..Results suggest the hypothesis that targeting and functional disruption of particular synapses by Abeta oligomers may provide a molecular basis for the specific loss of memory function in early AD...
  26. pmc alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    M G Spillantini
    Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, Cambridge CB2 2PY, United Kingdom
    Proc Natl Acad Sci U S A 95:6469-73. 1998
    ..These findings indicate that alpha-synuclein forms the major filamentous component of Lewy bodies and Lewy neurites...
  27. ncbi Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
    ..Thus, acidosis injures the brain via membrane receptor-based mechanisms with resultant toxicity of [Ca2+]i, disclosing new potential therapeutic targets for stroke...
  28. pmc Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
    Pablo Pelegrin
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    EMBO J 25:5071-82. 2006
  29. ncbi The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
    R Rohatgi
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 97:221-31. 1999
    ..Therefore, N-WASP and the Arp2/3 complex comprise a core mechanism that directly connects signal transduction pathways to the stimulation of actin polymerization...
  30. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    ..Thus, ngn3 is required for the specification of a common precursor for the four pancreatic endocrine cell types...
  31. ncbi Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 305:1292-5. 2004
    ..These findings may underlie the toxic gain-of-function by the mutants...
  32. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
    ..Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol...
  33. ncbi Vascular niche for adult hippocampal neurogenesis
    T D Palmer
    Stanford University, Department of Neurosurgery, Palo Alto, California 94305, USA
    J Comp Neurol 425:479-94. 2000
    ..This environment may provide a novel interface where mesenchyme-derived cells and circulating factors influence plasticity in the adult central nervous system...
  34. ncbi CLIP identifies Nova-regulated RNA networks in the brain
    Jernej Ule
    Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA
    Science 302:1212-5. 2003
    ..Thus, CLIP reveals that Nova coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA...
  35. pmc Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis
    Holly B Kordasiewicz
    Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Neuron 74:1031-44. 2012
    ..Rather than requiring continuous treatment, our findings establish a therapeutic strategy for sustained HD disease reversal produced by transient ASO-mediated diminution of huntingtin synthesis...
  36. ncbi BAR domains as sensors of membrane curvature: the amphiphysin BAR structure
    Brian J Peter
    Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 303:495-9. 2004
    ..From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module...
  37. pmc Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis
    Faraaz B Chekeni
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 467:863-7. 2010
    ..Collectively, these data identify PANX1 as a plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechanism of PANX1 activation by caspases...
  38. pmc Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis
    Kim B Jensen
    Laboratory for Epidermal Stem Cell Biology, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
    Cell Stem Cell 4:427-39. 2009
    ..Our results suggest that Lrig1-positive cells constitute a previously unidentified reservoir of adult mouse interfollicular epidermal stem cells...
  39. pmc Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
    Kirupa Sathasivam
    Department of Medical and Molecular Genetics, King s College London, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 110:2366-70. 2013
    ..RNA-targeted therapeutic strategies designed to lower the levels of HTT are under development. Many of these approaches would not prevent the production of exon 1 HTT and should be reviewed in light of our findings...
  40. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
    ..These findings identify a cellular and molecular target for the pungent action of mustard oils and support an emerging role for TRP channels as ionotropic cannabinoid receptors...
  41. ncbi SNAP receptors implicated in vesicle targeting and fusion
    T Sollner
    Rockefeller Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Nature 362:318-24. 1993
  42. pmc Rare deletions at the neurexin 3 locus in autism spectrum disorder
    Andrea K Vaags
    Program in Genetics and Genome Biology, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 90:133-41. 2012
    ..Notwithstanding these clinical complexities, this report on ASD-affected individuals who harbor NRXN3 exonic deletions advances the understanding of the genetic etiology of autism, further enabling molecular diagnoses...
  43. ncbi Protein aggregation and neurodegenerative disease
    Christopher A Ross
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Ross Research Building, Room 618, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Nat Med 10:S10-7. 2004
    ..There is now increased understanding of the pathways involved in protein aggregation, and some recent clues have emerged as to the molecular mechanisms of cellular toxicity. These are leading to approaches toward rational therapeutics...
  44. pmc Dendritic spine pathology in neuropsychiatric disorders
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 14:285-93. 2011
  45. pmc Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    Makiko Nagai
    Department of Neurology, Columbia University, 710 West 168th Street, New York, New York 10032, USA
    Nat Neurosci 10:615-22. 2007
    ..Identification of the astrocyte-derived soluble factor(s) may have far-reaching implications for ALS from both a pathogenic and therapeutic standpoint...
  46. pmc Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
    Alexander D Boiko
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304 5542, USA
    Nature 466:133-7. 2010
  47. pmc The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc
    Paul L Greer
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Cell 140:704-16. 2010
    ..We propose that this deregulation of AMPA receptor expression at synapses may contribute to the cognitive dysfunction that occurs in Angelman Syndrome and possibly other ASDs...
  48. ncbi Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation
    Simone Berkel
    Department of Molecular Human Genetics, Ruprecht Karls University, Heidelberg, Germany
    Nat Genet 42:489-91. 2010
    ..Our findings further link common genes between ASD and intellectual disability...
  49. pmc Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
    Michelle Gray
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 28:6182-95. 2008
    ..In summary, the BACHD model constitutes a novel and robust in vivo paradigm for the investigation of HD pathogenesis and treatment...
  50. ncbi Vertebrate neurogenesis is counteracted by Sox1-3 activity
    Magdalena Bylund
    Ludwig Institute of Cancer Research, Karolinska Institute, Box 240, SE 171 77 Stockholm, Sweden
    Nat Neurosci 6:1162-8. 2003
    ..These data suggest that the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins...
  51. pmc Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins
    Ethan R Graf
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 119:1013-26. 2004
  52. ncbi Immune recognition. A new receptor for beta-glucans
    G D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 413:36-7. 2001
    ..1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans...
  53. pmc DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212
    Ju Young Kim
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 63:761-73. 2009
  54. ncbi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008
  55. ncbi Disruption of two novel genes by a translocation co-segregating with schizophrenia
    J K Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Molecular Medicine Centre and MRC Human Genetics Unit, both at Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:1415-23. 2000
    ..Altogether, these observations indicate that DISC1 and DISC2 should be considered formal candidate genes for susceptibility to psychiatric illness...
  56. ncbi Neural stem and progenitor cells in nestin-GFP transgenic mice
    John L Mignone
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Comp Neurol 469:311-24. 2004
  57. pmc Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
    Joao Peca
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 472:437-42. 2011
    ..Our findings demonstrate a critical role for SHANK3 in the normal development of neuronal connectivity and establish causality between a disruption in the Shank3 gene and the genesis of autistic-like behaviours in mice...
  58. ncbi Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999
    ..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs...
  59. ncbi Neural circuitry that governs Drosophila male courtship behavior
    Petra Stockinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:795-807. 2005
    ..This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent...
  60. pmc ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes
    Sylvia O Suadicani
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Glia 60:1106-16. 2012
    ..Thus, on the basis of our present findings and our previous report, we propose that Panx1 channels serve as K(+) sensors for changes in the extracellular milieu such as those occurring under pathological conditions...
  61. ncbi Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
    G Schilling
    Department of Psychiatry, Division of Neuropathology, Johns Hopkins University, Baltimore, MD 21205 2196, USA
    Hum Mol Genet 8:397-407. 1999
    ..These findings are consistent with the idea that N-terminal fragments of huntingtin with a repeat expansion are toxic to neurons, and that N-terminal fragments are prone to form both intranuclear inclusions and neuritic aggregates...
  62. ncbi Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons
    P Scheiffele
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 101:657-69. 2000
    ..Our results suggest that neuroligins are part of the machinery employed during the formation and remodeling of CNS synapses...
  63. ncbi Neuroligin 2 is exclusively localized to inhibitory synapses
    Frederique Varoqueaux
    Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology, Gottingen, Germany
    Eur J Cell Biol 83:449-56. 2004
    ..Our findings identify neuroligin 2 as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization...
  64. ncbi Induction of pancreatic differentiation by signals from blood vessels
    E Lammert
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 294:564-7. 2001
    ..These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development...
  65. ncbi Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila
    Dhananjay A Wagh
    Lehrstuhl für Genetik und Neurobiologie, Theodor Boveri Institut für Biowissenschaften, Am Hubland, D 97074 Wurzburg, Germany
    Neuron 49:833-44. 2006
    ..We propose that BRP is critical for intact AZ structure and normal-evoked neurotransmitter release at chemical synapses of Drosophila...
  66. ncbi Isolation and characterization of multipotent skin-derived precursors from human skin
    Jean G Toma
    Department of Developmental Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Stem Cells 23:727-37. 2005
    ..Together, these data indicate that SKPs are an endogenous multipotent precursor cell present in human skin that can be isolated and expanded and differentiate into both neural and mesodermal cell types...
  67. pmc Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
    Janghoo Lim
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 452:713-8. 2008
    ..This model provides mechanistic insight into the molecular pathogenesis of SCA1 as well as other polyglutamine diseases...
  68. pmc Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders
    Christelle M Durand
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Nat Genet 39:25-7. 2007
    ..These mutations concern only a small number of individuals, but they shed light on one gene dosage-sensitive synaptic pathway that is involved in autism spectrum disorders...
  69. pmc The pannexin 1 channel activates the inflammasome in neurons and astrocytes
    William R Silverman
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 284:18143-51. 2009
    ..Thus, in contrast to macrophages and monocytes in which low intracellular K(+) has been suggested to trigger inflammasome activation, in neural cells, high extracellular K(+) activates caspase-1 probably through pannexin 1...
  70. ncbi Linear ubiquitination prevents inflammation and regulates immune signalling
    Bjorn Gerlach
    Tumour Immunology Unit, Department of Medicine, Imperial College London, W12 0NN London, UK
    Nature 471:591-6. 2011
    ..Our results provide evidence for the relevance of linear ubiquitination in vivo in preventing inflammation and regulating immune signalling...
  71. ncbi Activity-dependent proteolytic cleavage of neuroligin-1
    Kunimichi Suzuki
    Department of Neuropathology and Neuroscience, The University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 0033, Japan
    Neuron 76:410-22. 2012
    ..Collectively, neuronal activity-dependent proteolytic processing of NLG1 may negatively regulate the remodeling of spines at excitatory synapses...
  72. ncbi Neuroligins determine synapse maturation and function
    Frederique Varoqueaux
    Department of Molecular Neurobiology and Center for the Molecular Physiology of the Brain, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Neuron 51:741-54. 2006
    ..Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts...
  73. ncbi Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
    J S Steffan
    Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, California 92697, USA
    Nature 413:739-43. 2001
    ..These findings raise the possibility that therapy with HDAC inhibitors may slow or prevent the progressive neurodegeneration seen in Huntington's disease and other polyglutamine-repeat diseases, even after the onset of symptoms...
  74. ncbi HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin
    Atsushi Iwata
    Department of Biological Sciences, Bio X Program, Stanford University, Stanford, California 94305 5430, USA
    J Biol Chem 280:40282-92. 2005
    ..These data suggest that HDAC6-dependent retrograde transport on microtubules is used by cells to increase the efficiency and selectivity of autophagic degradation...
  75. pmc Neurexin-neuroligin signaling in synapse development
    Ann Marie Craig
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 2B5, Canada
    Curr Opin Neurobiol 17:43-52. 2007
  76. pmc Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:2115-29. 2010
  77. ncbi Differentiation of mouse embryonic stem cells into a defined neuronal lineage
    Miriam Bibel
    Friedrich Miescher Institute, CH 4058 Basel, Switzerland
    Nat Neurosci 7:1003-9. 2004
    ..As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics...
  78. ncbi Altered microRNA regulation in Huntington's disease models
    Soon Tae Lee
    Neurodegeneration Research Laboratory, Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea
    Exp Neurol 227:172-9. 2011
    ..Our results show that transgenic HD mice have abnormal miRNA biogenesis. This information should aid in future studies on therapeutic application of miRNAs in HD...
  79. pmc The immediate early gene arc/arg3.1: regulation, mechanisms, and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
    J Neurosci 28:11760-7. 2008
    ..In sum, Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to diverse forms of synaptic plasticity, thereby optimizing information storage in active networks...
  80. ncbi The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes
    C J Schoenherr
    Division of Biology 216 76, California Institute of Technology, Pasadena 91125
    Science 267:1360-3. 1995
    ..NRSF represents the first example of a vertebrate silencer protein that potentially regulates a large battery of cell type-specific genes, and therefore may function as a master negative regulator of neurogenesis...
  81. pmc Arc in synaptic plasticity: from gene to behavior
    Erica Korb
    Gladstone Institute of Neurological Disease, San Francisco, CA, USA
    Trends Neurosci 34:591-8. 2011
    ..We will also attempt to clarify how its molecular functions correspond to its requirement in various forms of plasticity, discuss Arc's role in behavior and disease, and highlight critical unresolved questions...
  82. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
    ..The encoded protein resembles extracellular matrix proteins involved in cell adhesion. The reeler phenotype thus seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin...
  83. ncbi Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    R Kruger
    Nat Genet 18:106-8. 1998
  84. ncbi Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    M H Polymeropoulos
    Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1430, USA
    Science 276:2045-7. 1997
    ..This finding of a specific molecular alteration associated with PD will facilitate the detailed understanding of the pathophysiology of the disorder...
  85. pmc SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
    Fumiyo Ikeda
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor Stern Kai 7, D 60590 Frankfurt, Main, Germany
    Nature 471:637-41. 2011
    ..In addition, SHARPIN deficiency leads to rapid cell death upon tumour-necrosis factor α (TNF-α) stimulation via FADD- and caspase-8-dependent pathways. SHARPIN thus activates NF-κB and inhibits apoptosis via distinct pathways in vivo...
  86. pmc Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
    Marta Martinez-Vicente
    Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Neurosci 13:567-76. 2010
    ..We propose that inefficient engulfment of cytosolic components by autophagosomes is responsible for their slower turnover, functional decay and accumulation inside HD cells...
  87. pmc The Arc of synaptic memory
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Exp Brain Res 200:125-40. 2010
    ..Arc holds considerable promise as a "master regulator" of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated...
  88. ncbi Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis
    Michael A Sutton
    Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 125:785-99. 2006
    ..These results indicate that NMDAR signaling during miniature synaptic transmission serves to stabilize synaptic function through active suppression of dendritic protein synthesis...
  89. ncbi CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
    Y Kawaguchi
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Nat Genet 8:221-8. 1994
    ..Southern blot analyses and genomic cloning demonstrates the existence of related genes. These results raise the possibility that similar abnormalities in related genes may give rise to diseases similar to MJD...
  90. ncbi Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
    M Trommsdorff
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Cell 97:689-701. 1999
    ..These findings suggest that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1...
  91. ncbi The autistic neuron: troubled translation?
    Raymond J Kelleher
    Center for Human Genetic Research, Harvard Partners Center for Genetics and Genomics, Massachusetts General Hospital, Program in Neuroscience and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 135:401-6. 2008
    ..We propose that aberrant synaptic protein synthesis may represent one possible pathway leading to autistic phenotypes, including cognitive impairment and savant abilities...
  92. pmc Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
    Andrew C Elden
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 466:1069-75. 2010
    ..Furthermore, these findings indicate that the TDP-43-ATXN2 interaction may be a promising target for therapeutic intervention in ALS and other TDP-43 proteinopathies...
  93. pmc CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila
    Christiane Zweier
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:655-66. 2009
    ..We therefore propose that an analogous shared synaptic mechanism contributes to the similar clinical phenotypes resulting from defects in human NRXN1 and CNTNAP2...
  94. pmc Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
    Stephane Jamain
    Laboratoire de génétique humaine et fonctions cognitives, Universite Paris 7, Institut National de la Santé et la Recherche Médicale E0021, 75015 Paris, France
    Nat Genet 34:27-9. 2003
    ..These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism...
  95. ncbi Wallerian degeneration, wld(s), and nmnat
    Michael P Coleman
    Laboratory of Molecular Signaling, The Babraham Institute, Cambridge CB223AT, United Kingdom
    Annu Rev Neurosci 33:245-67. 2010
  96. ncbi Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats
    Liliana B Menalled
    Department of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 465:11-26. 2003
    ..Because of their early behavioral anomalies and regionally specific pathology, these mice provide a powerful tool with which to evaluate the effectiveness of new therapies and to study the mechanisms involved in the neuropathology of HD...
  97. ncbi Reelin and brain development
    Fadel Tissir
    Developmental Genetics Unit, Universite Catholique de Louvain, UCL 7382, 73 Avenue E Mounier, B1200 Brussels, Belgium
    Nat Rev Neurosci 4:496-505. 2003
  98. pmc Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
    Akiko Hayashi-Takagi
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:327-32. 2010
    ..Furthermore, the concept of a signalosome involving disease-associated factors, such as DISC1 and glutamate, may well contribute to the multifactorial and polygenetic characteristics of schizophrenia...
  99. ncbi Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension
    Maurice A Curtis
    Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Science 315:1243-9. 2007
  100. ncbi The DISC locus in psychiatric illness
    J E Chubb
    Medical Genetics Section, The Centre for Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 13:36-64. 2008
    ..DISC1 is a hub protein in a multidimensional risk pathway for major mental illness, and studies of this pathway are opening up opportunities for a better understanding of causality and possible mechanisms of intervention...
  101. pmc Characterization of the proteome, diseases and evolution of the human postsynaptic density
    Alex Bayes
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, UK
    Nat Neurosci 14:19-21. 2011
    ..The hPSD is an important structure for nervous system disease and behavior...

Research Grants91

  1. Sustained, Non-viral Ocular Therapy Using Nanoparticles
    Muna Naash; Fiscal Year: 2006
    ..When taken together, these studies will provide valuable insight into non-viral gene therapy as a prospective method for the treatment of inherited blinding diseases. [unreadable] [unreadable] [unreadable]..
    Harry Orr; Fiscal Year: 2002
    ..To gain insight into ataxin-7 function a series of experiments are proposed to characterize the cellular and subcellular expression of ataxin-7 and to identify proteins that interact with ataxin-7 using the yeast two-hybrid system. ..
  3. Androgens and apoE4 induced cognitive impairments
    Jacob Raber; Fiscal Year: 2005
  4. Neurochemical Correlates of Pathology in Spinocerebellar Ataxias
    GULIN OZ; Fiscal Year: 2008
    ..Successful application of such treatments is expected to reduce the burden caused by these diseases on individuals, their families and society. [unreadable] [unreadable] [unreadable]..
    Kenneth Hensley; Fiscal Year: 2005
    ..abstract_text> ..
  6. Microarrays for Alzheimer's Disease Mouse Models
    P Reddy; Fiscal Year: 2003
    ..The outcome of this proposed investigation will be useful in screening several mitochondrial antioxidants in AD transgenic mouse models as pre-clinical trials of AD patients...
  7. Nectin-1: Synaptic processing and functions
    Howard J Federoff; Fiscal Year: 2010
    ..Subsequently, we examine whether expression of trans-dominant nectin-1 mutants will affect hippocampal dependent learning ..
    Alexander Varshavsky; Fiscal Year: 2007
    ..cerevisiae. ..
  9. Nicotinic and neuroprotection in a parkinson mouse model
    Maryka Quik; Fiscal Year: 2007
    ..This may allow for the design of neuroprotective strategies for PD, a disorder for which only symptomatic treatment is currently available. ..
  10. Neural Bases of Auditory Processing Disorders in Adults
    Patrick Wong; Fiscal Year: 2007
    ..2) Whether it is feasible to use MRI to identify neurophysiologic anomalies in APD adults. If so, whether APD is associated with a collection of unifying or diverse neurophysiologic anomalies. [unreadable] [unreadable]..
    Neal Swerdlow; Fiscal Year: 2006
  12. Proteomic Biomarker Discovery in PD
    Howard Federoff; Fiscal Year: 2006
    ..We believe that these unique and innovative studies will provide a wealth of proleomics information that will translate to improved PD diagnosis and evaluation of therapeutic interventions. [unreadable] [unreadable]..
    Marina Emborg; Fiscal Year: 2003
    ..These studies will serve as the preclinical foundation to determine whether this in vivo method to deliver these potent trophic factor and antiapoptotic genes will be suitable for testing in patients with PD. ..
  14. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  15. Peripheral Macrophage Signatures of Inflammation in Neurodegenerative Diseases
    Howard Federoff; Fiscal Year: 2008
    ..As such, it is necessary to develop easily accessible, robust, specific, and sensitive biomarkers of early AD and PD, which would greatly facilitate the diagnosis and treatment of these diseases. [unreadable] [unreadable] [unreadable]..
  16. Parkinson's Disease Gene Therapy Study Group
    Howard Federoff; Fiscal Year: 2006
    ..Focus 5: Development of a hioethics approach to PD gene therapy. PP VIII. "Measuring and Explaining PD Patients' Participation Preferences Regarding Phase I Studies in Gene Transfer Therapy" (PI: Kim). ..
  17. Association and Function of Opioid Receptor Gene Variants to Substance Dependence
    Huiping Zhang; Fiscal Year: 2008
    ..Jeffrey Gruen (co-mentor), who are both excellent supervisors with substantial experience in genetic studies of complex disorders and who have both mentored numerous previous trainees. [unreadable] [unreadable] [unreadable]..
  18. Nicotinic Receptors in Parkinson's Disease
    Maryka Quik; Fiscal Year: 2007
    ..These data together with the results of the behavioral studies may form a basis for the use of nicotinic drugs in the treatment of Parkinson's disease. [unreadable] [unreadable]..
  19. Bioscope II - AFM system for Nanoimaging Core Facility
    Yuri Lyubchenko; Fiscal Year: 2007
    ..There are two NIH funded investigators outside the campus who also want to use the unique features of the integrated Bioscope/IX71 system. [unreadable] [unreadable] [unreadable]..
  20. Chronic drug exposures in monkeys: serial MRI studies
    Marc Kaufman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  21. Physiology and genetics of food procurement in rodents
    Neil Rowland; Fiscal Year: 2008
    ..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
  22. Nicotinic Receptor Template-guided Drug Design
    Palmer Taylor; Fiscal Year: 2008
    ..The final stages of investigation will include studies in rodents to determine efficacy and toxicity. ..
  23. CBP Acetyltransferase Function in Addictive Behavior
    Mark Mayford; Fiscal Year: 2007
    ..In this way we hope to expand our understanding of the transcriptional control of addictive mechanisms and identify new targets for potential therapeutic intervention. [unreadable] [unreadable] [unreadable]..
  24. Genomic Characterization in Depression and Suicide.
    Etienne Sibille; Fiscal Year: 2007
    ..The training program proposes formal courses, supervised training and frequent interactions with several research groups involved in pioneering aspects of genomic research in mood disorders. [unreadable] [unreadable]..
  25. Development & Applications of Knowledge-based Potentials
    Yaoqi Zhou; Fiscal Year: 2006
    ..The successful completion of the proposed studies will likely lead to a new generation of algorithms for more accurate structure determination. ..
  26. In vivo role of Rho-kinase in glucose metabolism
    Young Bum Kim; Fiscal Year: 2007
    ..These experiments could lead to the identification of a potential target for new diabetes drugs. [unreadable] [unreadable] [unreadable]..
    Grazyna Adamus; Fiscal Year: 2008
    ..unreadable] [unreadable]..
    Stephen Scheff; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  29. Cell Model of Parkinson's Disease and Screening for Therapeutic Compounds
    Wenzhen Duan; Fiscal Year: 2008
    ..Our proposed research has potential to find compounds which are neuroprotective and further be taken to preclinical and clinical trials of PD. [unreadable] [unreadable] [unreadable]..
  30. GM1 Ganglioside Effects on Parkinson's Disease
    Jay Schneider; Fiscal Year: 2007
    ..Working hypothesis: Long-term GM1 use will stabilize symptoms or slow the progression of symptoms in PD patients and this may be accompanied by reduced loss of striatal DA terminals over time. [unreadable] [unreadable]..
  31. Magnetic Resonance, EEG, and Behavior After Cocaine
    Marc Kaufman; Fiscal Year: 2008
    ..This work will facilitate the direct comparison of neurochemical data across species. ..
    MARINA PICCIOTTO; Fiscal Year: 2009
    ..We propose that this mouse model may have implications for the development of psychiatric disorders in subjects exposed to nicotine in utero. ..
    Howard Federoff; Fiscal Year: 2004
    ..abstract_text> ..
  34. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
  35. Single-chain Antibody Therapy for Prion Disease
    Howard Federoff; Fiscal Year: 2003
    ..Efficacy will be assessed by end-point PrPsc levels in brains and spleens of treated, challenged mice. Gross motor coordination behavioral will also be evaluated in treated mice by rota-rod performance. ..
    Harry Orr; Fiscal Year: 2003
    ..Understanding the importance of these factors for SCA1 pathogenesis should provide insights for polyglutamine diseases in general. ..
    Willis K Samson; Fiscal Year: 2010
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
  38. Altered Inhibitory Prefrontal Circuitry in Schizophrenia
    DAVID VOLK; Fiscal Year: 2003
    ..After a 3 month survival period, we will quantify any changes in the mRNA expression of PFC GABA markers using in situ hybridization and grain counting techniques. ..
  39. Blood-Brain-CSF Barriers, CNS Homeostasis, Drug Delivery
    MARTHA O DONNELL; Fiscal Year: 2002
    ..It is also intended to have three open workshops/debates during the meeting. One is already in place on "Microdialysis". The maximum permitted attendance at this meeting is 150 scientists. ..
  40. Neurobiological Basis for Cold Transduction
    David D McKemy; Fiscal Year: 2010
    ..With this animal model, we are investigating the peripheral projections of cold-sensitive afferents, the mechanisms of cold adaptation in native cells, and the in vivo role of these neurons in somatosensation. ..
    DIPAK SARKAR; Fiscal Year: 2002
    DIPAK SARKAR; Fiscal Year: 2002
    ..abstract_text> ..
    JOSE RIZO REY; Fiscal Year: 2002
    ..abstract_text> ..
  44. Genetic Screen For Oxidative Resistance in Mice
    Mark Mayford; Fiscal Year: 2002
    ..Although beyond the scope of this pilot grant, any heritable mutants will ultimately be positionally cloned to identify the molecular determinants of the observed phenotype. ..
  45. Mechanisms of HIV-Induced PNS Disease: The SIV Macaque Model
    Joseph Mankowski; Fiscal Year: 2009
    ..The goal of these comprehensive, integrated studies of HIV sensory neuropathy in our novel SIV primate model is to advance the understanding of HIV-SN pathogenesis to foster new therapeutic approaches. ..
    Palmer Taylor; Fiscal Year: 2003
    ..The Centralized Animal Facility is critically needed to support this effort and allow economies of scale for animal research. ..
  47. Ultra High Field 9.4T Animal Magnetic Resonance Scanner
    Marc Kaufman; Fiscal Year: 2004
    ..4 Tesla animal scanner. ..
  48. Dopamine, mutant synuclein, oxidative stress and inflammation
    Howard J Federoff; Fiscal Year: 2010
    ..Particularly we will study early changes in PD. The results of these studies may lead to the identIfication of potential therapies for PD. ..
  49. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
    ..abstract_text> ..
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  51. Effort-related Functions of Nucleus Accumbens Adenosine A2A Receptors
    John D Salamone; Fiscal Year: 2010
  52. Nanomedicine Center for Protein Deposition Diseases(RMI)
    Yuri Lyubchenko; Fiscal Year: 2004
    ..We assembled a multidisciplinary team of 12 investigators with broad expertise in nanobiology, imaging, spectroscopy, single molecule biophysics, proteomics, drug delivery and medicine. ..
  53. Regulation of growth and pruning of neuronal arbors
    Peter Scheiffele; Fiscal Year: 2010
    ..Moreover, defects in a-chimaerins have been proposed to be associated with autism and schizophrenia. Understanding the cellular functions of a-chimaerins is therefore highly relevant for human health. ..
  54. Learning and Adaptation in Primary Visual Cortex
    ANDREW TEICH; Fiscal Year: 2005
    ..The goal of Specific Aim 2 is to experimentally test the prediction that adaptation in alert, non-anesthetized subjects causes physiological changes that are a transient version of the changes seen in learning. ..
    DIPAK SARKAR; Fiscal Year: 2009
  56. Mucociliary Function in Chronic Bronchitis
    MATTHIAS A SALATHE; Fiscal Year: 2010
    ..The results of the proposed experiments, using novel and state-of-the-art methods, will provide new and important mechanistic insights into the regulation of mucociliary clearance in chronic bronchitis. ..
    Rodney L Parsons; Fiscal Year: 2010
    Grazyna Adamus; Fiscal Year: 2001
    ..3) Examine the role of cytokines and chemokines in the recruitment of cell to the eye in primary and recurrent uveitis associated with EAE after immunization of Lewis rats with MBP. ..
  59. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    Howard Federoff; Fiscal Year: 2002
    ..4) Bioinformatics methods to extract genetic regulatory networks from mined profile data. ..
  61. Anatomical Tracing of Activated Brain Circuits
    Mark Mayford; Fiscal Year: 2006
    ..The mice developed would have broad utility in studies of neuronal processing both in the study of normal brain function and in disease models. ..
    Ronald Wetzel; Fiscal Year: 2005
    ..An improved knowledge of structure will also improved our ability to identify and design therapeutic molecules for inhibiting the growth and toxicity of A-beta amyloid and other aggregates. ..
    Samuel Jacobson; Fiscal Year: 2001
    ..The results of this research will lead to the formulation of hypotheses about the underlying molecular events in these diseases and may evolve into recommendations for treatment paradigms in these blinding retinal degenerations. ..
    John Salamone; Fiscal Year: 2003
    ..Taken together, the results of these experiments will help to identify the pharmacological characteristics and brain circuits that underlie the motor effects of clozapine. ..
    Craig Stevens; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  66. Modulation of parasympathetic neurons by PACAP peptides
    RODNEY PARSONS; Fiscal Year: 2005
  67. TRPM4 Channels in the Control of Cerebral Artery Tone
    Scott Earley; Fiscal Year: 2005
    ..It is anticipated that these studies will generate significant new information regarding the role of mechanosensitive cation channels in the regulation of VSM membrane potential and the regulation of cerebral blood flow. ..
    Hidekazu Tsukamoto; Fiscal Year: 2005
    ..abstract_text> ..
  69. Genetic Determinants of Dental Fluorosis
    ERIC EVERETT; Fiscal Year: 2006
    ..This knowledge will allow optimal use of fluorides for an individual in the prevention of dental caries while minimizing the risks of excessive fluoride. [unreadable] [unreadable]..
  70. High Density Association Analysis of Lung Cancer
    Christopher I Amos; Fiscal Year: 2010
    ..We are collaborating with the International Lung Cancer Consortium so that it can further validate our findings for a variety of different populations, in future initiatives. ..
  71. Structure and mechanism of signal peptide peptidase
    Michael S Wolfe; Fiscal Year: 2010
    ..A structure of SPP would provide tremendous insight into the workings of an unusual new class of enzymes that are critical to both biology and medicine. ..
  72. Neurogenesis, Inflammation and Irradiation Injury
    ..abstract_text> ..
  73. GRSA Proteins in the Diagnosis of Breast Cancer
    WILLIAM NORTH; Fiscal Year: 2002
    ..These methods could be applicable to all patients with breast cancer or suspected breast cancer. ..
  74. The Role of Presenilin in Gamma-Secretase Activity
    Michael Wolfe; Fiscal Year: 2009
    ..for substrate-protease recognition? (3) What is the role of Aph-1 and NCT in the assembly and activity of the protease complex? (4) How do mutations in PS that cause familial AD alter the specificity and activity of gamma-secretase? ..
  75. Time-Dependent Changes in Respiratory Control After Perinatal Hyperoxia
    RYAN BAVIS; Fiscal Year: 2008
    ..Therefore, it is critical to understand how environmental conditions in early life influence development of protective chemoreflexes. [unreadable] [unreadable] [unreadable]..
  76. Aspartame Intake and the Risk of Cancer
    Eva Schernhammer; Fiscal Year: 2008
    ..Our results may help decision-makers formulate guidelines and direct future aspartame studies. Even a null finding would be important in this context. [unreadable] [unreadable] [unreadable]..
    Benjamin Gelman; Fiscal Year: 2007
    ..abstract_text> ..
  78. Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease
    Hoon Ryu; Fiscal Year: 2009
    ..These studies will provide novel mechanisms for preventing mitochondrial transcriptional dysfunction and help in the design of applicable compounds that modulate mitochondrial function. ..
  79. Preventing spike-wave epileptogenesis: critical periods & neuroimaging biomarkers
    Hal Blumenfeld; Fiscal Year: 2010
    ..untreated animals. We will also investigate the anatomical basis of white matter DTI abnormalities through electron microscopy to determine changes in axons and myelin in affected regions. 2. ..
  80. Inducible expression of mutant DISC1: transgenic mouse model
    Mikhail Pletnikov; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  81. Neural Melanocortin Signaling and Erectile Function
    Hunter Wessells; Fiscal Year: 2005
    ..The findings may allow us to develop receptor-specific therapeutic strategies, which may ultimately be beneficial to men and women with sexual dysfunction. ..
  82. APP, Alzheimer's Disease, and Synaptic Function
    THOMAS SUDHOF; Fiscal Year: 2008
    ..Together these studies will contribute to our understanding of APP function and Abeta toxicity in AD, and may suggest new avenues for interfering with the pathogenesis of AD. ..
  83. Genetic Susceptibility for Lung Cancer in African Americans
    Christopher Amos; Fiscal Year: 2009
    ..This analysis will allow us to identify groups of African-American individuals at particularly higher risks for developing lung cancer. ..
  84. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2006
    ..Finally, we will apply the methods that we are developing as part of existing studies of obesity, cancer-predisposition and rheumatoid arthritis. ..
  85. Liability Markers for Deficit Schizophrenia?
    L Hong; Fiscal Year: 2004
    ..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
  86. Pak1 - PIN Pathway in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2008
    ..Our proposed research is significant as this research might form the basis for new advances in identifying novel molecular targets, detecting, preventing and treating breast cancer, by identifying PIN as a key regulatory nodule. ..
  87. Sodium Channel Dysfunction and Epilepsy
    Andrew Escayg; Fiscal Year: 2008
    ..The GEFSP2 mice will be a valuable resource and will be made available to the scientific community. ..
  88. HER2 Pathway in Breast Cancer Progression and Treatment
    Rakesh Kumar; Fiscal Year: 2007
    ..abstract_text> ..
  89. Identifying molecular path of behavioural phenotype in schizophrenia
    L Hong; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  90. Mechanism of photoreceptor cell degeneration in animal models of retinal diseases
    Muna Naash; Fiscal Year: 2008
    ..cone OSs morphogenesis and maintenance. Experiments put forth in this application will provide biochemical and physiological evidence for the role of Rds and its associated proteins during genesis of rod and cone OSs. ..