caveolins

Summary

Summary: The main structural proteins of CAVEOLAE. Several distinct genes for caveolins have been identified.

Top Publications

  1. ncbi Caveolae: from cell biology to animal physiology
    Babak Razani
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Pharmacol Rev 54:431-67. 2002
  2. ncbi Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    M Drab
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D 01307 Dresden, Germany
    Science 293:2449-52. 2001
  3. ncbi Regulated portals of entry into the cell
    Sean D Conner
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 422:37-44. 2003
  4. ncbi Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, The Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:38121-38. 2001
  5. ncbi Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
    Babak Razani
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:8635-47. 2002
  6. ncbi Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
    Oleg O Glebov
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 8:46-54. 2006
  7. ncbi Evidence for a regulated interaction between heterotrimeric G proteins and caveolin
    S Li
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 270:15693-701. 1995
  8. ncbi Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center and the Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 276:6727-38. 2001
  9. ncbi The multiple faces of caveolae
    Robert G Parton
    Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia
    Nat Rev Mol Cell Biol 8:185-94. 2007
  10. ncbi Exploring the caves: cavins, caveolins and caveolae
    Carsten G Hansen
    MRC LMB, Cambridge, UK
    Trends Cell Biol 20:177-86. 2010

Detail Information

Publications273 found, 100 shown here

  1. ncbi Caveolae: from cell biology to animal physiology
    Babak Razani
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Pharmacol Rev 54:431-67. 2002
    ..However, since the identification of a family of proteins termed "caveolins", that form and reside in caveolae, a better understanding has emerged...
  2. ncbi Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    M Drab
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D 01307 Dresden, Germany
    Science 293:2449-52. 2001
    ..Thus, caveolin-1 and caveolae play a fundamental role in organizing multiple signaling pathways in the cell...
  3. ncbi Regulated portals of entry into the cell
    Sean D Conner
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 422:37-44. 2003
    ....
  4. ncbi Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, The Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:38121-38. 2001
    ....
  5. ncbi Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
    Babak Razani
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:8635-47. 2002
    ..Our results show for the first time a clear role for caveolins in systemic lipid homeostasis in vivo and place caveolin-1/caveolae as major factors in hyperlipidemias and ..
  6. ncbi Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
    Oleg O Glebov
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 8:46-54. 2006
    ..We propose that flotillin-1 is one determinant of a clathrin-independent endocytic pathway in mammalian cells...
  7. ncbi Evidence for a regulated interaction between heterotrimeric G proteins and caveolin
    S Li
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 270:15693-701. 1995
    ..These data suggest that caveolin could function to negatively regulate the activation state of heterotrimeric G proteins...
  8. ncbi Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center and the Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 276:6727-38. 2001
    ..We localize the Type I TGF-beta receptor interaction to the scaffolding domain of Cav-1 and show that it occurs in a physiologically relevant time frame, acting to rapidly dampen signaling initiated by the TGF-beta receptor complex...
  9. ncbi The multiple faces of caveolae
    Robert G Parton
    Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia
    Nat Rev Mol Cell Biol 8:185-94. 2007
    ....
  10. ncbi Exploring the caves: cavins, caveolins and caveolae
    Carsten G Hansen
    MRC LMB, Cambridge, UK
    Trends Cell Biol 20:177-86. 2010
    ..Until recently, the only extensively characterised protein components of caveolae were the caveolins. Recently, data from several laboratories have demonstrated that a family of four related proteins, termed ..
  11. ncbi Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
    David A Zacharias
    Department of Pharmacology, Biomedical Sciences Graduate Program, and, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093 0647, USA
    Science 296:913-6. 2002
    ..Thus the nature of the lipid anchor on a protein is sufficient to determine submicroscopic localization within the plasma membrane...
  12. pmc Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation
    John H Chidlow
    Vascular Biology and Therapeutics Program, Department of Pharmacology, Yale University School of Medicine, Amistad Research Building, 10 Amistad Street, New Haven, CT 06520, USA
    Cardiovasc Res 86:219-25. 2010
    ..The organization and functions of caveolae are mediated by coat proteins (caveolins) and support or adapter proteins (cavins)...
  13. pmc Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae
    Eva Maria Damm
    Institute of Biochemistry, Swiss Federal Institute of Technology Zurich ETHZ, CH 8093 Zurich, Switzerland
    J Cell Biol 168:477-88. 2005
    ..Our results revealed the existence of a virus-activated endocytic pathway from the plasma membrane to the ER that involves neither clathrin nor caveolae and that can be activated also in the presence of cav-1...
  14. pmc Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation
    Chao Chi Ho
    Department of Pathology, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taipei, Taiwan
    Am J Pathol 161:1647-56. 2002
    ..We further revealed that up-regulated caveolin-1 in CL cells is necessary for mediating filopodia formation, which may enhance the invasive ability of lung adenocarcinoma cells...
  15. ncbi Caveolins and caveolae, roles in insulin signalling and diabetes
    Peter Stralfors
    Department of Clinical and Experimental Medicine, University of Linkoping, Linkoping, Sweden
    Adv Exp Med Biol 729:111-26. 2012
    ..Lack of caveolae makes animals and human beings insulin resistant, but there is presently no evidence that caveolae play a role in the pathogenesis of insulin resistance in obesity and Type 2 diabetes...
  16. pmc Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol
    A Bist
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 94:10693-8. 1997
    ..The findings of this study are consistent with the postulated role for caveolin as a regulator of cellular FC homeostasis in quiescent peripheral cells, and the coordinate regulation by SREBP of FC influx and efflux...
  17. pmc Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice
    You Yang Zhao
    University of California at San Diego, Institute of Molecular Medicine, 9500 Gilman Drive, BSB 0623, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 99:11375-80. 2002
    b>Caveolins are important components of caveolae, which have been implicated in vesicular trafficking and signal transduction...
  18. ncbi Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade
    Scott E Woodman
    Department of Molecular Pharmacology, Division of Hormone Dependent Tumor Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:38988-97. 2002
    ..These results are consistent with previous in vitro data demonstrating that caveolins may function as negative regulators of the p42/44 MAPK cascade...
  19. ncbi Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains
    K S Song
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 271:9690-7. 1996
    ....
  20. ncbi Redox regulation of ischemic preconditioning is mediated by the differential activation of caveolins and their association with eNOS and GLUT-4
    Srikanth Koneru
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
    Am J Physiol Heart Circ Physiol 292:H2060-72. 2007
    ....
  21. ncbi Caveolin-1 is a negative regulator of caveolae-mediated endocytosis to the endoplasmic reticulum
    Phuong U Le
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 277:3371-9. 2002
    ..Caveolin-1 stabilizes the plasma membrane association of caveolae and thereby acts as a negative regulator of the caveolae-mediated endocytosis of AMF-R to the endoplasmic reticulum...
  22. pmc Identification, sequence, and expression of caveolin-2 defines a caveolin gene family
    P E Scherer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142 1479, USA
    Proc Natl Acad Sci U S A 93:131-5. 1996
    ..b>Caveolins 1 and 2 are similar in most respects...
  23. pmc Caveolin-1 and -2 in the exocytic pathway of MDCK cells
    P Scheiffele
    Cell Biology Programme, European Molecular Biology Laboratory, D 69012 Heidelberg, Germany
    J Cell Biol 140:795-806. 1998
    We have studied the biosynthesis and transport of the endogenous caveolins in MDCK cells. We show that in addition to homooligomers of caveolin-1, heterooligomeric complexes of caveolin-1 and -2 are formed in the ER...
  24. ncbi Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
    J Couet
    The Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 272:30429-38. 1997
    ..within the kinase domain of the EGF-R can mediate the interaction of the EGF-R with the scaffolding domains of caveolins 1 and 3 but not with caveolin 2...
  25. ncbi Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease
    Andrew F G Quest
    Centro FONDAP de Estudios Molecualrs de la Célula, Programa de Biologia Celular y Molecular, Universidad de Chile, Indepencia 1027, Santiago, Chile
    Biochem Cell Biol 82:129-44. 2004
    ..Here, more recent data addressing the role of caveolin-1 in cellular signaling and the development of diseases like cancer will be preferentially discussed...
  26. ncbi Alterations in membrane cholesterol that affect structure and function of caveolae
    Eric J Smart
    Department of Physiology, University of Kentucky Medical School, Lexington, Kentucky 40536, USA
    Methods Enzymol 353:131-9. 2002
    ..When used correctly, these methods are accepted as a specific way to perturb the structure and function of caveolae...
  27. ncbi Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains
    F Galbiati
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 275:23368-77. 2000
    ..These results suggest that caveolin-1 expression can modulate Wnt/beta-catenin/Lef-1 signaling by regulating the intracellular localization of beta-catenin...
  28. ncbi CAP defines a second signalling pathway required for insulin-stimulated glucose transport
    C A Baumann
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Nature 407:202-7. 2000
    ..Thus, localization of the Cbl-CAP complex to lipid rafts generates a pathway that is crucial in the regulation of glucose uptake...
  29. pmc Host but not parasite cholesterol controls Toxoplasma cell entry by modulating organelle discharge
    Isabelle Coppens
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8022, USA
    Mol Biol Cell 14:3804-20. 2003
    ..Cholesterol back-addition into host plasma membrane reverses this inhibitory effect of depletion on parasite secretion. These data define a new mechanism by which host cholesterol specifically controls entry of an intracellular pathogen...
  30. pmc Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation
    Franco Capozza
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 162:2029-39. 2003
    ..Our results provide the first genetic evidence that caveolin-1 indeed functions as a tumor suppressor gene in vivo...
  31. ncbi Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities
    F Galbiati
    Department of Molecular Pharmacology, Albert Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:21425-33. 2001
    ..These results have clear mechanistic implications for understanding the pathogenesis of LGMD-1C at a molecular level...
  32. ncbi Caveolae and caveolins in the respiratory system
    Reinoud Gosens
    Department of Molecular Pharmacology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Curr Mol Med 8:741-53. 2008
    ..They owe their characteristic Omega-shape to complexes of unique proteins, the caveolins, which indirectly tether cholesterol and sphingolipid-enriched membrane microdomains to the cytoskeleton...
  33. ncbi Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo
    S Li
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479 and Research Genetics, Huntsville, Alabama 35801, USA
    J Biol Chem 271:3863-8. 1996
    ....
  34. ncbi Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle
    Z Tang
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 271:2255-61. 1996
    ..Our results also suggest that other as yet unknown caveolin family members are likely to exist and may be expressed in a regulated or tissue-specific fashion...
  35. ncbi Caveolae and caveolins
    R G Parton
    Department of Physiology and Pharmacology, Centre for Molecular and Cellular Biology, University of Queensland, 4072Brisbane, Australia
    Curr Opin Cell Biol 8:542-8. 1996
    ..of VIP21-caveolin as a cholesterol-binding oligomeric protein, and evidence for functional interactions between caveolins and heterotrimeric G proteins...
  36. pmc Caveolin-deficient mice: insights into caveolar function human disease
    B Razani
    Department of Molecular Pharmacology, Division of Hormone Dependent Tumor Biology, The Albert Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 108:1553-61. 2001
  37. ncbi Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy
    C Minetti
    Servizio Malattie Neuro Muscolari, Universita di Genova, Istituto Giannina Gaslini, Genoa, Italy
    Nat Genet 18:365-8. 1998
    ..b>Caveolins are the principal protein components of caveolae (50-100 nm invaginations found in most cell types) which ..
  38. ncbi Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum
    Phuong U Le
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada
    J Cell Sci 116:1059-71. 2003
    ..Two distinct caveolae-mediated endocytic pathways therefore exist, including a novel direct pathway to the ER from the plasma membrane...
  39. ncbi Membrane microdomains and caveolae
    T V Kurzchalia
    Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Opin Cell Biol 11:424-31. 1999
    ..several recent papers have suggested that caveolae, which are considered to be a specific form of raft, and caveolins, the major membrane proteins of caveolae, are involved in the dynamic cholesterol-dependent regulation of ..
  40. ncbi Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria
    W P Li
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
    J Cell Sci 114:1397-408. 2001
    ..We conclude that caveolin-1 can be targeted to a variety of intracellular destinations, which suggests a novel mechanism for the intracellular traffic of this protein...
  41. pmc Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas
    K Wiechen
    Institute of Pathology, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Am J Pathol 158:833-9. 2001
    ..In addition, re-expression of caveolin-1 in HT-1080 fibrosarcoma cells potently inhibited colony formation. From these we conclude that caveolin-1 is likely to act as a tumor suppressor gene in human sarcomas...
  42. ncbi Role of caveolae and caveolins in health and disease
    Alex W Cohen
    Dept of Molecular Pharmacology and the Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Physiol Rev 84:1341-79. 2004
    ..That so many signaling molecules and signaling cascades are regulated by an interaction with the caveolins provides a paradigm by which numerous disease processes may be affected by ablation or mutation of these ..
  43. ncbi Caveolins and cellular cholesterol balance
    E Ikonen
    Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Traffic 1:212-7. 2000
    b>Caveolins are major integral membrane components of caveolae. Over the last few years, evidence has accumulated for a close link between caveolin, caveolae, and the regulation of cellular cholesterol levels...
  44. ncbi Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells
    Ayesha N Shajahan
    Department of Pharmacology, University of Illinois, College of Medicine, M C 868, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    J Biol Chem 279:20392-400. 2004
    ..Thus, Src-mediated phosphorylation of dynamin-2 is an essential requirement for scission of caveolae and the resultant transendothelial transport of albumin...
  45. ncbi Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy
    Takeharu Hayashi
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 313:178-84. 2004
    ..It was observed that the Thr63Ser mutation reduced the cell surface expression of caveolin-3, albeit the change was mild as compared with the LGMD mutations. These observations suggest that HCM is a clinical spectrum of CAV3 mutations...
  46. ncbi Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton
    Dorothy I Mundy
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    J Cell Sci 115:4327-39. 2002
    ..The behavior of cavicles suggests that they function as transport intermediates between caveolae and caveosomes...
  47. ncbi Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins
    K S Song
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 271:15160-5. 1996
    ..These results are consistent with previous immunoelectron microscopic studies demonstrating that dystrophin is localized to plasma membrane caveolae in smooth muscle cells...
  48. pmc A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes
    Mikko Karjalainen
    Department of Biological and Environmental Science Nanoscience Center, University of Jyvaskyla, FI 40351 Jyväskylä, Finland
    Mol Biol Cell 19:2857-69. 2008
    ..Our results together suggest that alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes...
  49. ncbi Caveolin scaffolding region and the membrane binding region of SRC form lateral membrane domains
    Stephen P Wanaski
    Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA
    Biochemistry 42:42-56. 2003
    ..Consequently, protein-induced membrane domains may affect cell signaling by organizing signal transduction components within the membrane and changing reaction rates...
  50. ncbi Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe
    D Volonte
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 274:12702-9. 1999
    Caveolae are vesicular organelles that represent a subcompartment of the plasma membrane. Caveolins and flotillins are two families of mammalian caveolae-associated integral membrane proteins...
  51. ncbi Caveolins and heart diseases
    Mathivadhani Panneerselvam
    Department of Anesthesiology, University of California, San Diego, CA, USA
    Adv Exp Med Biol 729:145-56. 2012
    b>Caveolins serve as a platform in plasma membrane associated caveolae to orchestrate various signaling molecules to effectively communicate extracellular signals into the interior of cell...
  52. ncbi Caveolins: structure and function in signal transduction
    Wanda M Krajewska
    University of Łódź, Department of Cytobiochemistry, Banacha 12 16, 90 237 Łódź, Poland
    Cell Mol Biol Lett 9:195-220. 2004
    ..These microdomains are referred to as/called caveolae. Caveolins are small proteins (18-24 kDa) that have a hairpin loop conformation with both the N and C termini exposed to ..
  53. ncbi Caveolin-1 expression enhances endothelial capillary tubule formation
    Jun Liu
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:10661-8. 2002
    ....
  54. ncbi P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins
    Julie Jodoin
    Laboratoire de Medecine Moleculaire, Centre de cancérologie Charles Bruneau, Universite du Quebec a Montreal, Hopital Sainte Justine, Montreal, Quebec, Canada
    J Neurochem 87:1010-23. 2003
    ..Thus, P-gp expressed at the BBB is mainly localized in caveolae and its activity may be modulated by interaction with caveolin-1...
  55. ncbi Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo
    P E Scherer
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 272:29337-46. 1997
    ..purpose, we generated a novel mono-specific monoclonal antibody probe that recognizes only caveolin-2, but not caveolins-1 and -3...
  56. ncbi Caveolae structure and function
    CANDICE M THOMAS
    Department of Pediatrics and the Kentucky Pediatric Research Institute, University of Kentucky, Lexington, KY, USA
    J Cell Mol Med 12:796-809. 2008
    ..This brief review will discuss a few of the key features of caveolae as it relates to signalling and disease processes...
  57. ncbi Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells
    Jürgen Zschocke
    Neurodegeneration Group, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Biol Chem 277:38772-80. 2002
    ..The observed mechanism of gene silencing by ER alpha may have implications for the transcriptional regulation of further ER alpha target genes...
  58. ncbi Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase
    Haojie Wang
    Department of Pharmacology and Medicine, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 279:17250-9. 2004
    ..Clearly, the caveolar Na(+)/K(+)-ATPase represents the signaling pool of the pump that interacts with Src and transmits the ouabain signals...
  59. pmc Impairment of caveolae formation and T-system disorganization in human muscular dystrophy with caveolin-3 deficiency
    Carlo Minetti
    Servizio Malattie Neuro Muscolari, Dipartimento di Pediatria, Universita di Genova, Istituto G Gaslini, Genova, Italy
    Am J Pathol 160:265-70. 2002
    ..These observations provide new perspectives in our understanding of the role of caveolin-3 in muscle and of the pathogenesis of muscle weakness in caveolin-3 deficient muscle...
  60. pmc Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells
    Federica Sotgia
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 22:3905-26. 2002
    The relationship between glycosylphosphatidyl inositol (GPI)-linked proteins and caveolins remains controversial...
  61. pmc Ligand-independent activation of oestrogen receptor alpha by caveolin-1
    A Schlegel
    Department of Molecular Pharmacology, The Albert Einstein Cancer Centre, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochem J 359:203-10. 2001
    ..Thus caveolin-1 is a novel ERalpha regulator that drives ERK1/2-independent phosphorylation and activation of AF-1...
  62. ncbi The proprotein convertase furin colocalizes with caveolin-1 in the Golgi apparatus and endosomes of hepatocytes
    Gaetan Mayer
    Departement de pathologie et biologie cellulaire, Universite de Montreal, PO Box 6128, Montreal, Quebec, H3C 3J7, Canada
    Cell Tissue Res 316:55-63. 2004
    ..Our results suggest that, in addition to the Golgi, furin-/caveolin-1-containing endosomes could represent a compartment where furin processes its substrates at the basolateral domain of the hepatocyte...
  63. ncbi Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms
    Robert G Parton
    Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis, and School of Biomedical Sciences, University of Queensland, Queensland, 4072, Australia
    Traffic 4:724-38. 2003
    ..exquisite sensitivity to cholesterol-sequestering agents, can involve caveolae but also exist in cells devoid of caveolins and caveolae...
  64. pmc Caveolins in vascular smooth muscle: form organizing function
    Christopher D Hardin
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Cardiovasc Res 69:808-15. 2006
    ..In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions of smooth muscle: contraction, growth/proliferation, and the ..
  65. ncbi Isoforms of caveolin-1 and caveolar structure
    T Fujimoto
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Cell Sci 113:3509-17. 2000
    ..When made to be expressed in HepG2 cells lacking endogenous caveolins, the alpha isoform formed caveolar depressions efficiently, but the beta isoform hardly did so...
  66. ncbi Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic
    Lucas Pelkmans
    Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Cell 118:767-80. 2004
    ....
  67. ncbi Hepatic overexpression of caveolins increases bile salt secretion in mice
    Mauricio Moreno
    Departamento de Gastroenterologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Hepatology 38:1477-88. 2003
    b>Caveolins are cholesterol-binding proteins involved in the regulation of several intracellular processes, including cholesterol transport...
  68. ncbi Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays
    Harriet Wikman
    Departments of Medical Genetics and Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
    J Pathol 203:584-93. 2004
    ..Some of these genes may provide novel diagnostic markers for lung cancer...
  69. pmc Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade
    David S Park
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biol Cell 13:3416-30. 2002
    ..In addition, the Ras-p42/44 MAPK cascade is hyper-activated. Because a similar premature lactation phenotype is observed in SOCS1 (-/-) null mice, we conclude that caveolin-1 is a novel suppressor of cytokine signaling...
  70. ncbi The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo
    K Das
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 274:18721-8. 1999
    The mammalian caveolin gene family consists of caveolins-1, -2, and -3. The expression of caveolin-3 is muscle-specific...
  71. pmc Caveolae and sorting in the trans-Golgi network of epithelial cells
    P Dupree
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 12:1597-605. 1993
    ..This connection is confirmed by the recent finding that the amino acid sequence of VIP21 is almost identical to that of caveolin, a protein previously localized to caveolae...
  72. ncbi Caveolins and macrophage lipid metabolism
    Peter Gargalovic
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Lipid Res 44:11-21. 2003
    ..Although caveolins are ubiquitously expressed, the majority of the available information comes from differentiated cells rich in ..
  73. ncbi Elevated expression of caveolin-1 in adenocarcinoma of the colon
    S W Fine
    Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
    Am J Clin Pathol 115:719-24. 2001
    b>Caveolins 1, 2, and 3 are the principal proteins of caveolae, the vesicular invaginations of the plasma membrane. Several reports have suggested that caveolin-1 may have a role in cellular transformation and tumorigenesis...
  74. ncbi Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors
    X Feng
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    J Biol Chem 276:8341-9. 2001
    ..These findings suggest that intracellular distribution of activated TNF receptors may be regulated by caveolin-1 via its interaction with TRAF2...
  75. pmc Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell
    T Fujimoto
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Cell Biol 152:1079-85. 2001
    ..It also suggests that LD is related to trafficking of lipid molecules mediated by caveolins.
  76. ncbi Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation
    M L Lu
    Division of Urologic Surgery, Department of Surgery, Renal Division, Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:13442-51. 2001
    ..Using a mammalian two-hybrid assay system, we determine that the NH(2) terminus region of caveolin-1 is responsible for the interaction with both the NH(2)-terminal domain and the ligand-binding domain of AR...
  77. ncbi Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae
    Lucas Pelkmans
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nature 436:128-33. 2005
    ..Our observations reveal new principles in caveolae trafficking and suggest that the dynamic properties of caveolae and their transport competence are regulated by different kinases operating at several levels...
  78. ncbi Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways
    T R Bilderback
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045, USA
    J Biol Chem 274:257-63. 1999
    ..In summary, our results suggest that the interaction of caveolin with neurotrophin receptors may have functional consequences in regulating signaling through p75(NTR) and Trk A in neuronal and glial cell populations...
  79. pmc Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport
    Eric J Smart
    Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 101:3450-5. 2004
    ..Pharmacological treatment of mice with ezetimibe disrupts the heterocomplex in only hypercholesterolemic animals. These data suggest that ANX2 and CAV1 are components of an intestinal sterol transport complex...
  80. ncbi Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3). Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31)
    J A Engelman
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    FEBS Lett 429:330-6. 1998
    b>Caveolins (Cav-1, -2, and -3) are a gene family of cytoplasmic membrane-anchored scaffolding proteins that: (i) help to sculpt caveolae membranes from the plasma membrane proper; and (ii) participate in the sequestration of inactive ..
  81. ncbi Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    J Lipid Res 43:579-89. 2002
    ..These studies demonstrate that NPC1 regulates cholesterol transport to caveolin-1 and caveolin-2 containing compartments such as the TGN and plasma membrane caveolae...
  82. ncbi Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells
    L Li
    Scott Department of Urology, Baylor College of Medicine, 6560 Fannon, Houston, TX 77030, USA
    Cancer Res 61:4386-92. 2001
    ....
  83. ncbi Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae
    D J Dietzen
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 270:6838-42. 1995
    ..Thus, palmitoylation of cysteine residues in nonmembrane spanning Src family protein tyrosine kinases has different consequences than in the transmembrane protein caveolin...
  84. pmc Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol
    Lyne Labrecque
    Centre de cancérologie Charles Bruneau, Hopital Sainte Justine, Montreal, Quebec, Canada H3T 1C5
    Mol Biol Cell 14:334-47. 2003
    ..Overall, these results suggest that caveolin-1 plays multiple roles in the VEGF-induced signaling cascade...
  85. pmc Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts
    J R Glenney
    Lucille P Markey Cancer Center, Lexington, KY
    Proc Natl Acad Sci U S A 89:10517-21. 1992
    ..This includes brightly fluorescent membrane patches in many cases concentrated at the margin of cells and in arrays. Caveolae may be distinct from other membrane domains due at least in part to caveolin...
  86. ncbi Role of GTP hydrolysis in fission of caveolae directly from plasma membranes
    J E Schnitzer
    Department of Pathology, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA
    Science 274:239-42. 1996
    ..Thus, caveolae may bud to form discrete carrier vesicles that participate in membrane trafficking...
  87. pmc VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles
    T V Kurzchalia
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 118:1003-14. 1992
    ..The transiently expressed protein appeared on the Golgi-apparatus, the plasma membrane and vesicular structures. We propose that VIP21 is a component of the molecular machinery of vesicular transport...
  88. ncbi Do caveolins regulate cells by actions outside of caveolae?
    Brian P Head
    Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
    Trends Cell Biol 17:51-7. 2007
    ..Recent work shows that caveolins can act independently of caveolae, both in cells that lack caveolae (e.g...
  89. ncbi Caveolae and caveolin-3 in muscular dystrophy
    F Galbiati
    Department of Pharmacology, University of Pittsburgh School of Medicine, Biomedical Science Tower (BST, Rm E1356, Pittsburgh, PA 15261, USA
    Trends Mol Med 7:435-41. 2001
    ..By contrast, upregulation of the caveolin-3 protein is associated with Duchenne muscular dystrophy (DMD). Thus, tight regulation of caveolin-3 appears essential for maintaining normal muscle health and homeostasis...
  90. ncbi Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae
    Lucas Pelkmans
    Swiss Federal Institute of Technology Zurich ETHZ, HPM1 Building, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 296:535-9. 2002
    ..They were necessary for formation of caveolae-derived endocytic vesicles and for infection of the cell. Thus, caveolar endocytosis is ligand-triggered and involves extensive rearrangement of the actin cytoskeleton...
  91. pmc Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets
    A G Ostermeyer
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    J Cell Biol 152:1071-8. 2001
    ....
  92. ncbi The role of caveolae and caveolin in vesicle-dependent and vesicle-independent trafficking
    S Matveev
    University of Kentucky Medical School, Department of Physiology, 800 Rose Street, Lexington, KY 40536, USA
    Adv Drug Deliv Rev 49:237-50. 2001
    ..Caveolin also influences the formation, morphology, and function of caveolae. The ability of caveolae and caveolin to mediate macromolecular transport directly impacts a variety of physiological and pathophysiological processes...
  93. pmc Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization
    Paula Upla
    Cell Biology, University of Jyvaskyla, FIN 40351 Jyvaskyla, Finland
    Mol Biol Cell 15:625-36. 2004
    ..In addition to natural ligands human echovirus-1 (EV1) gains entry into the cell by binding to alpha 2 beta 1 and taking advantage of alpha 2 beta 1 internalization via caveolae...
  94. ncbi Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines
    J A Engelman
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    FEBS Lett 448:221-30. 1999
    ..identified five independent BAC clones (approximately 100-200 kb) containing D7S522 and the human genes encoding caveolins 1 and 2...
  95. ncbi Caveolin, caveolae, and endothelial cell function
    Philippe G Frank
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Arterioscler Thromb Vasc Biol 23:1161-8. 2003
    ..These novel findings suggest an important role for caveolin-1 in the pathogenesis of cancer, atherosclerosis, and vascular disease...
  96. ncbi Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains
    Todd E Fox
    Department of Pharmacology College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Biol Chem 282:12450-7. 2007
    ..Taken together, these data demonstrate that structured membrane microdomains are necessary for ceramide-induced activation of PKC zeta and resultant diminished Akt activity, leading to vascular smooth muscle cell growth arrest...
  97. pmc Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles
    Matthew Kirkham
    Institute for Molecular Bioscience, University of Queensland, Queensland 4072, Australia
    J Cell Biol 168:465-76. 2005
    ..These carriers contained GPI-anchored proteins and fluid phase markers and represented the major vehicles mediating CTB uptake in both WT and caveolae-null cells...
  98. pmc Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice
    Terence M Williams
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Biol Cell 14:1027-42. 2003
    ..This is the first in vivo demonstration that caveolin-1 can function as a transformation suppressor gene...
  99. pmc Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking
    Peter Thomsen
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, DK 2200 Copenhagen N, Denmark
    Mol Biol Cell 13:238-50. 2002
    ..We therefore conclude that caveolae are not involved in constitutive endocytosis but represent a highly stable plasma membrane compartment anchored by the actin cytoskeleton...
  100. pmc Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae
    Babak Razani
    Department of Molecular Pharmacology, Institute for Smooth Muscle Biology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 22:2329-44. 2002
    ..Taken together, our data show for the first time a specific role for caveolin-2 in mammalian physiology independent of caveolin-1...
  101. ncbi Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo
    G Garcia-Cardena
    Department of Pharmacology, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 272:25437-40. 1997
    ....

Research Grants62

  1. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..Caveolae are specialized microdomains containing the structural proteins, caveolins that bind, organize and regulate receptors and signaling molecules involved in numerous cell functions including ..
  2. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..My long-term goals are to study the pathways and the molecular mechanisms by which the caveolins are involved in IPF...
  3. Analysis of the Spatiotemporal Regulation of Lipolysis
    Lisa M DiPilato; Fiscal Year: 2012
    ..In this proposal, I set out to elucidate signaling complexes formed by key scaffolding proteins, caveolins and A kinase anchoring proteins (AKAPs) at lipid droplets that organize the spatiotemporal regulation of ..
  4. Mechanical Signaling Mechanisms in Cardiac Tissue
    David E Dostal; Fiscal Year: 2013
    ..These studies will involve the role of caveolins and in mediating regulation of JNK and p381, as well as temporal regulation of the cross-talk mechanisms that ..
  5. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
    ..In this regard, the role of caveolae and caveolins in the lung is an exciting and emerging area of research...
  6. Role of Caveolin in Scleroderma Tissue Fibrosis and Vasculopathy
    Sergio A Jimenez; Fiscal Year: 2012
    ..Recent studies on idiopathic PAH and idiopathic pulmonary fibrosis identified caveolins as important participants in the pathogenesis of both diseases...
  7. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
    ..The PI will introduce anti-sense constructs for Rab3A, Rab3D, caveolins 1, 2, and 3, PKC epsilon, PKC zeta, osteonectin, and adipocyte alpha3 VI collagen...
  8. Caveolae and adipocyte lipid metabolism
    Paul F Pilch; Fiscal Year: 2013
    ..They are comprised of small integral membrane proteins, caveolins 1 &2, and peripheral membrane proteins of the cavin family (cavin-1- 3)...
  9. Caveolae, T-type Calcium Channels and Cardiac Hypertrophy
    RAVI CHANDRA BALIJEPALLI; Fiscal Year: 2013
    ..Certain proteins such as caveolins and Ca2+ channels found in the heart control the cardiac contractile function and could offer protection during ..
  10. Beta-1 Integrin and Caveolin-3 in Cardiac Mechanotransduction
    ROBERT SCOTT ROSS; Fiscal Year: 2013
    ..Key proteins of these areas are the integrins and caveolins. Integrins are a large family of cell- surface adhesive receptors that are also signaling molecules in virtually ..
  11. Exercise as a novel strategy to target methamphetamine-induced cerebrovascular to
    Michal Toborek; Fiscal Year: 2013
    ..We believe that the data obtained from this proposal will provide evidence that even moderate exercise can significantly contribute to brain regeneration in chronic cerebrovascular disorders. ..
  12. Integrins and Caveolin Proteins in Cardiac Hypertrophy and Failure
    David M Roth; Fiscal Year: 2013
    ..Identification of root causes of cardiac dysfunction and importantly, studies which could lead to novel therapeutics of this common disease, are essential, and will be the focus of this proposal. ..
  13. Investigation of Caveolin Structure, Topology, and Oligomerization
    Kerney Jebrell Glover; Fiscal Year: 2013
    ..b>Caveolins (1, 2, and 3) are the most important proteins found in caveolae, and are responsible for giving caveolae their ..
  14. Implications of caveolae in Tat signaling and integrity of brain endothelium
    Min Seon Park; Fiscal Year: 2012
    ..localization of Tat to caveolae, the subset of lipid rafts characterized by the presence of proteins termed caveolins. The importance of this observation is related to the fact that a variety of cell surface receptors and ..
  15. Caveolins, Caveolae, and Lipid Rafts
    DOUGLAS LUBLIN; Fiscal Year: 2004
    ....
  16. Structure and Function of Membrane Rafts
    Deborah Brown; Fiscal Year: 2009
    ..There are three caveolin proteins in mammalian cells: caveolins-1, -2, and -3. Caveolins 1 and 2 are usually co-expressed, while caveolin-3 is restricted to muscle cells...
  17. Caveolae in Insulin Signaling
    CYNTHIA MASTICK; Fiscal Year: 2007
    ..the characterization of a unique insulin-stimulated signaling pathway that leads to tyrosine phosphorylation of caveolins-1 and -2, structural components of specialized cell surface domains termed caveolae...
  18. CAVEOLINS, SIGNALING AND CELL TRANSFORMATION
    Michael Lisanti; Fiscal Year: 2008
    ..endothelia vs. fatty stromal cells (mammary adipocytes), in the context of mammary tumorigenesis. ..
  19. Caveolae and Anesthetic Induced Cardiac Protection
    David M Roth; Fiscal Year: 2010
    ..b>Caveolins, proteins abundant in caveolae, provide a scaffold to organize, traffic and regulate signaling molecules...
  20. Raft/Caveolar Mechanisms in Pulmonary Hypertension
    PRAVIN SEHGAL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. Novel Actions of Estradiol that Influence Brain Function
    Paul G Mermelstein; Fiscal Year: 2010
    ..abstract_text> ..
  22. CELLULAR PHYSIOLOGY OF STAT3
    PRAVIN SEHGAL; Fiscal Year: 2002
    ..Establishing the basic subunit structure of the cytosolic 200-400 kDa and 1-2 MDa STAT3-containing complexes in IL-6-free and IL-6-treated cells is a sine qua non for further progress in this field. ..
  23. Caveolin-1/lGF-IR Interactions in Oligodendrocytes
    Daniel Mikol; Fiscal Year: 2004
    ..Understanding the interplay between the IGF-IR and caveolin-1 and their control of OLG phenotype will provide insight into the molecular basis of myelination by OLGs and, hopefully, guide new treatments for MS. ..
  24. NFAT-mediated gene expression and striatal plasticity
    PAUL MERMELSTEIN; Fiscal Year: 2008
    ..Ultimately, this project will lead to a better understanding of the role NFAT-dependent transcription plays in shaping long-term changes in brain function. ..
  25. NEW PATHWAY LIMITS CELLULAR CHOLESTEROL CONTENT
    Phoebe Fielding; Fiscal Year: 2004
    ..Each of these studies has significant relevance to the basis of FC accumulation in atherosclerosis. ..
  26. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    ..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
  27. Pulsed EPR Spectrometer
    Timothy Springer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTOR
    Senitiroh Hakomori; Fiscal Year: 2003
    ..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..
  29. Notch Signaling and Satellite Cell Activation
    THOMAS RANDO; Fiscal Year: 2009
    ..abstract_text> ..
  30. PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURY
    DIPAK DAS; Fiscal Year: 2009
    ....
  31. ASYMMETRIC DISTRIBUTION OF CHOLESTEROL IN MEMBRANES
    Friedhelm Schroeder; Fiscal Year: 2010
    ..If this process were understood, new therapeutic targets for increasing cholesterol efflux for lowering plasma cholesterol could potentially be developed. ..
  32. Thrombin,Sepsis and Mechanisms of Inflammation
    Chinnaswamy Tiruppathi; Fiscal Year: 2010
    ..It is hoped that this work will lead to the development of new drug targeting acute lung injury associated with leaky lung microvessel and tissue edema formation. ..
  33. Caveolae Mediated Bacterial Uptake in the Urinary Tract
    Soman N Abraham; Fiscal Year: 2010
    ....
  34. Adrenergic and Purinergic Regulation of Target Cells
    Paul A Insel; Fiscal Year: 2010
    ..MDCK and mpkCCD cells and assessment of sumoylation (a novel modification that we have recently identified) of caveolins;2) Functional roles of renal P2Y and adrenergic receptors using receptor-knockout mice...
  35. BONE FACTORS AND ENDOCHONDRAL OSSIFICATION
    Barbara Boyan; Fiscal Year: 2001
    ..It is suggested that these results will provide insight into the role these factors play in bone development and repair. ..
  36. Cocaine Regulation of Norepinephrine Transporter
    LANKUPALLE JAYANTHI; Fiscal Year: 2005
    ..Results from these studies will provide valuable scientific insights to our understanding of the role of drugs of abuse in regulating NET function and expression. ..
  37. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2005
    ..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
  38. Beta-Adrenergic Receptors of S49 Lymphoma Cells
    Paul Insel; Fiscal Year: 2005
    ..Moreover, the results should prove applicable to the many other hormone and neurotransmitter receptors that link to G proteins. ..
  39. GORDON CONF. MACROMOLECULAR ORGANIZATION & CELL FUNCTION
    CHRISTOPHER HARDIN; Fiscal Year: 2004
    ..Although much of the program is now in place, a number of slots are being kept open for presentations on the most recent developments in this rapidly-moving field, which will be filled early next year. ..
  40. GENE EXPRESSION IN LIMB GIRDLE MUSCULAR DYSTROPHY
    Elizabeth McNally; Fiscal Year: 2004
    ..Together, these experiments will outline the temporal profile of gene expression changes that arise in these disorders. ..
  41. Development of Hydrogel Spinal Disc Replacement
    Barbara Boyan; Fiscal Year: 2004
    ..abstract_text> ..
  42. IGG PLACENTAL TRANSPORT: ENDOTHELIAL CAVEOLAE
    John Robinson; Fiscal Year: 2004
    ..Our approaches to testing the predictions of this hypothesis incorporate methods of cell biology, immunology, biochemistry, ultrastructural analysis, and molecular biology. ..
  43. MOLECULAR DETERMINANTS OF CALCIUM RECEPTOR FUNCTION
    GERDA BREITWIESER; Fiscal Year: 2002
    ..abstract_text> ..
  44. DOPAMINE 2002
    Kim Neve; Fiscal Year: 2002
    ..The banquet will feature informal talks by 2000 Nobel Prize Laureates, Arvid Carlsson and Paul Greengard, and the opening lecture will be given by Marc Caron, the organizer of Dopamine '94 in Quebec City. ..
  45. Cellular Signaling and Muscular Dystrophies
    THOMAS RANDO; Fiscal Year: 2005
    ..of muscular dystrophy are due to abnormalities of membrane proteins and protein complexes, such as integrins and caveolins, that are known to regulate cellular signaling pathways in general, and cell survival signaling in particular, ..
  46. Postdoctoral Training in Renal Diseases and Hypertension
    BRUCE KONE; Fiscal Year: 2006
    ..It is the goal of the Program that its graduates will contribute to a new generation of academic nephrologists and renal investigators equipped to address the challenging problems in renal diseases and hypertension ..
  47. Failure of FasL Mediated Pathways in Tumor Angiogenesis
    Vijay Shah; Fiscal Year: 2006
    ..These insights may lead to novel and effective therapeutic strategies that target this pathway to prevent angiogenesis, and thereby prevent colorectal tumor development growth and spread. ..
  48. Characterization of Human Trace Amine Receptors
    Kim Neve; Fiscal Year: 2006
    ..TARs encoding full-length receptors are expressed on the cell surface, to identify agonists and antagonists for each TAR subtype, and to identify allelic variants that alter the function or ligand binding of a TAR subtype ..
  49. Metabolic Organization by the Caveolae and Cytoskeleton
    CHRISTOPHER HARDIN; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  50. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2006
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  51. New Directions in Biology and Disease of Skeletal Muscle
    Elizabeth McNally; Fiscal Year: 2006
    ..In addition, there will be two poster sessions. Trainees are strongly encouraged to attend and participate. [unreadable] [unreadable] [unreadable]..
  52. The Pathogenesis and Genetics of Environmental Asthma
    JONATHAN STAMLER; Fiscal Year: 2007
    ..In aggregate, the coupled scientific findings in this program will substantially enhance our understanding of the pathogenesis and genetics of asthma. ..
  53. Insulin Resistance and ABCA1 Transporter Function
    WILLIAM GARVER; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  54. Endothelial Nitric Oxide Synthase & Portal Hypertension
    Vijay Shah; Fiscal Year: 2002
    ..abstract_text> ..
  55. Pseudomonas invasion and the role of caveolin-2
    David Zaas; Fiscal Year: 2008
    ..A better understanding of these events is required for the eventual development of new adjunctive therapiesand possible prophylactic strategies for high risk patients. ..
  56. Feedback and Hormonal Regulation of Hepatic HMG-CoA Reductase
    GENE CHARLES NESS; Fiscal Year: 2010
    ....
  57. REGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN KIDNEY
    BRUCE KONE; Fiscal Year: 2002
    ....
  58. NEUROPEPTIDE-STEROID INTERACTIONS IN THE CNS
    Paul Micevych; Fiscal Year: 2003
    ..These experiments will not only tell us about the actions of steroids in specific circuits, but they will also provide important information about the interactions of neuropeptide circuits regulating behavior. ..
  59. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 2003
    ..In the inhibitory effect is confirmed, its mechanism will be studied in relation to activities of SDKs, MAPK, bcl-2, and other signal transducers. ..
  60. GPCRs: Evolving Concepts and Drug Discovery
    Paul Insel; Fiscal Year: 2004
    ..Attendees will thus have the chance to learn and discuss new cutting edge topics regarding GPCRs. ..
  61. Trafficking of Triacylglycerol in Adipocytes
    Perry Bickel; Fiscal Year: 2007
    ..By these studies, fundamental mechanisms of intracellular lipid trafficking should be revealed. ..
  62. LIGAND RECEPTOR INTERACTIONS IN UTIS
    SOMAN ABRAHAM; Fiscal Year: 2008
    ..In the age of increasing antibiotic resistance in bacteria and where the population of the aged and immunocompromised individuals continues to grow, these studies could prove to be extremely valuable. ..