caveolins

Summary

Summary: The main structural proteins of CAVEOLAE. Several distinct genes for caveolins have been identified.

Top Publications

  1. ncbi The multiple faces of caveolae
    Robert G Parton
    Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia
    Nat Rev Mol Cell Biol 8:185-94. 2007
  2. ncbi Exploring the caves: cavins, caveolins and caveolae
    Carsten G Hansen
    MRC LMB, Cambridge, UK
    Trends Cell Biol 20:177-86. 2010
  3. ncbi Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
    Oleg O Glebov
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 8:46-54. 2006
  4. ncbi Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center and the Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 276:6727-38. 2001
  5. ncbi Evidence for a regulated interaction between heterotrimeric G proteins and caveolin
    S Li
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 270:15693-701. 1995
  6. ncbi Regulated portals of entry into the cell
    Sean D Conner
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 422:37-44. 2003
  7. ncbi Caveolae: from cell biology to animal physiology
    Babak Razani
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Pharmacol Rev 54:431-67. 2002
  8. pmc Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation
    John H Chidlow
    Vascular Biology and Therapeutics Program, Department of Pharmacology, Yale University School of Medicine, Amistad Research Building, 10 Amistad Street, New Haven, CT 06520, USA
    Cardiovasc Res 86:219-25. 2010
  9. pmc Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice
    You Yang Zhao
    University of California at San Diego, Institute of Molecular Medicine, 9500 Gilman Drive, BSB 0623, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 99:11375-80. 2002
  10. ncbi Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
    David A Zacharias
    Department of Pharmacology, Biomedical Sciences Graduate Program, and, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093 0647, USA
    Science 296:913-6. 2002

Detail Information

Publications250 found, 100 shown here

  1. ncbi The multiple faces of caveolae
    Robert G Parton
    Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4072, Australia
    Nat Rev Mol Cell Biol 8:185-94. 2007
    ....
  2. ncbi Exploring the caves: cavins, caveolins and caveolae
    Carsten G Hansen
    MRC LMB, Cambridge, UK
    Trends Cell Biol 20:177-86. 2010
    ..Until recently, the only extensively characterised protein components of caveolae were the caveolins. Recently, data from several laboratories have demonstrated that a family of four related proteins, termed ..
  3. ncbi Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
    Oleg O Glebov
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 8:46-54. 2006
    ..We propose that flotillin-1 is one determinant of a clathrin-independent endocytic pathway in mammalian cells...
  4. ncbi Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center and the Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 276:6727-38. 2001
    ..We localize the Type I TGF-beta receptor interaction to the scaffolding domain of Cav-1 and show that it occurs in a physiologically relevant time frame, acting to rapidly dampen signaling initiated by the TGF-beta receptor complex...
  5. ncbi Evidence for a regulated interaction between heterotrimeric G proteins and caveolin
    S Li
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 270:15693-701. 1995
    ..These data suggest that caveolin could function to negatively regulate the activation state of heterotrimeric G proteins...
  6. ncbi Regulated portals of entry into the cell
    Sean D Conner
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 422:37-44. 2003
    ....
  7. ncbi Caveolae: from cell biology to animal physiology
    Babak Razani
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Pharmacol Rev 54:431-67. 2002
    ..However, since the identification of a family of proteins termed "caveolins", that form and reside in caveolae, a better understanding has emerged...
  8. pmc Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation
    John H Chidlow
    Vascular Biology and Therapeutics Program, Department of Pharmacology, Yale University School of Medicine, Amistad Research Building, 10 Amistad Street, New Haven, CT 06520, USA
    Cardiovasc Res 86:219-25. 2010
    ..The organization and functions of caveolae are mediated by coat proteins (caveolins) and support or adapter proteins (cavins)...
  9. pmc Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice
    You Yang Zhao
    University of California at San Diego, Institute of Molecular Medicine, 9500 Gilman Drive, BSB 0623, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 99:11375-80. 2002
    b>Caveolins are important components of caveolae, which have been implicated in vesicular trafficking and signal transduction...
  10. ncbi Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
    David A Zacharias
    Department of Pharmacology, Biomedical Sciences Graduate Program, and, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093 0647, USA
    Science 296:913-6. 2002
    ..Thus the nature of the lipid anchor on a protein is sufficient to determine submicroscopic localization within the plasma membrane...
  11. ncbi Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, The Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:38121-38. 2001
    ....
  12. ncbi Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
    J Couet
    The Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 272:30429-38. 1997
    ..within the kinase domain of the EGF-R can mediate the interaction of the EGF-R with the scaffolding domains of caveolins 1 and 3 but not with caveolin 2...
  13. pmc Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae
    Eva Maria Damm
    Institute of Biochemistry, Swiss Federal Institute of Technology Zurich ETHZ, CH 8093 Zurich, Switzerland
    J Cell Biol 168:477-88. 2005
    ..Our results revealed the existence of a virus-activated endocytic pathway from the plasma membrane to the ER that involves neither clathrin nor caveolae and that can be activated also in the presence of cav-1...
  14. ncbi Redox regulation of ischemic preconditioning is mediated by the differential activation of caveolins and their association with eNOS and GLUT-4
    Srikanth Koneru
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
    Am J Physiol Heart Circ Physiol 292:H2060-72. 2007
    ....
  15. ncbi Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    M Drab
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D 01307 Dresden, Germany
    Science 293:2449-52. 2001
    ..Thus, caveolin-1 and caveolae play a fundamental role in organizing multiple signaling pathways in the cell...
  16. pmc Caveolin-1 and -2 in the exocytic pathway of MDCK cells
    P Scheiffele
    Cell Biology Programme, European Molecular Biology Laboratory, D 69012 Heidelberg, Germany
    J Cell Biol 140:795-806. 1998
    We have studied the biosynthesis and transport of the endogenous caveolins in MDCK cells. We show that in addition to homooligomers of caveolin-1, heterooligomeric complexes of caveolin-1 and -2 are formed in the ER...
  17. pmc Identification, sequence, and expression of caveolin-2 defines a caveolin gene family
    P E Scherer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142 1479, USA
    Proc Natl Acad Sci U S A 93:131-5. 1996
    ..b>Caveolins 1 and 2 are similar in most respects...
  18. ncbi Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways
    T R Bilderback
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045, USA
    J Biol Chem 274:257-63. 1999
    ..In summary, our results suggest that the interaction of caveolin with neurotrophin receptors may have functional consequences in regulating signaling through p75(NTR) and Trk A in neuronal and glial cell populations...
  19. ncbi Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains
    F Galbiati
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 275:23368-77. 2000
    ..These results suggest that caveolin-1 expression can modulate Wnt/beta-catenin/Lef-1 signaling by regulating the intracellular localization of beta-catenin...
  20. ncbi The role of caveolae and caveolin in vesicle-dependent and vesicle-independent trafficking
    S Matveev
    University of Kentucky Medical School, Department of Physiology, 800 Rose Street, Lexington, KY 40536, USA
    Adv Drug Deliv Rev 49:237-50. 2001
    ..Caveolin also influences the formation, morphology, and function of caveolae. The ability of caveolae and caveolin to mediate macromolecular transport directly impacts a variety of physiological and pathophysiological processes...
  21. ncbi P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins
    Julie Jodoin
    Laboratoire de Medecine Moleculaire, Centre de cancérologie Charles Bruneau, Universite du Quebec a Montreal, Hopital Sainte Justine, Montreal, Quebec, Canada
    J Neurochem 87:1010-23. 2003
    ..Thus, P-gp expressed at the BBB is mainly localized in caveolae and its activity may be modulated by interaction with caveolin-1...
  22. pmc Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation
    Franco Capozza
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 162:2029-39. 2003
    ..Our results provide the first genetic evidence that caveolin-1 indeed functions as a tumor suppressor gene in vivo...
  23. pmc Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation
    Chao Chi Ho
    Department of Pathology, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taipei, Taiwan
    Am J Pathol 161:1647-56. 2002
    ..We further revealed that up-regulated caveolin-1 in CL cells is necessary for mediating filopodia formation, which may enhance the invasive ability of lung adenocarcinoma cells...
  24. ncbi Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo
    G Garcia-Cardena
    Department of Pharmacology, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 272:25437-40. 1997
    ....
  25. ncbi CAP defines a second signalling pathway required for insulin-stimulated glucose transport
    C A Baumann
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Nature 407:202-7. 2000
    ..Thus, localization of the Cbl-CAP complex to lipid rafts generates a pathway that is crucial in the regulation of glucose uptake...
  26. pmc Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae
    Babak Razani
    Department of Molecular Pharmacology, Institute for Smooth Muscle Biology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 22:2329-44. 2002
    ..Taken together, our data show for the first time a specific role for caveolin-2 in mammalian physiology independent of caveolin-1...
  27. ncbi Caveolin-1 expression enhances endothelial capillary tubule formation
    Jun Liu
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:10661-8. 2002
    ....
  28. ncbi Caveolins: structure and function in signal transduction
    Wanda M Krajewska
    University of Łódź, Department of Cytobiochemistry, Banacha 12 16, 90 237 Łódź, Poland
    Cell Mol Biol Lett 9:195-220. 2004
    ..These microdomains are referred to as/called caveolae. Caveolins are small proteins (18-24 kDa) that have a hairpin loop conformation with both the N and C termini exposed to ..
  29. ncbi Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities
    F Galbiati
    Department of Molecular Pharmacology, Albert Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:21425-33. 2001
    ..These results have clear mechanistic implications for understanding the pathogenesis of LGMD-1C at a molecular level...
  30. pmc Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol
    A Bist
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 94:10693-8. 1997
    ..The findings of this study are consistent with the postulated role for caveolin as a regulator of cellular FC homeostasis in quiescent peripheral cells, and the coordinate regulation by SREBP of FC influx and efflux...
  31. ncbi Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle
    Z Tang
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 271:2255-61. 1996
    ..Our results also suggest that other as yet unknown caveolin family members are likely to exist and may be expressed in a regulated or tissue-specific fashion...
  32. ncbi Caveolae and caveolins in the respiratory system
    Reinoud Gosens
    Department of Molecular Pharmacology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Curr Mol Med 8:741-53. 2008
    ..They owe their characteristic Omega-shape to complexes of unique proteins, the caveolins, which indirectly tether cholesterol and sphingolipid-enriched membrane microdomains to the cytoskeleton...
  33. ncbi Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo
    S Li
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479 and Research Genetics, Huntsville, Alabama 35801, USA
    J Biol Chem 271:3863-8. 1996
    ....
  34. ncbi Caveolae and caveolins
    R G Parton
    Department of Physiology and Pharmacology, Centre for Molecular and Cellular Biology, University of Queensland, 4072Brisbane, Australia
    Curr Opin Cell Biol 8:542-8. 1996
    ..of VIP21-caveolin as a cholesterol-binding oligomeric protein, and evidence for functional interactions between caveolins and heterotrimeric G proteins...
  35. pmc Caveolin-deficient mice: insights into caveolar function human disease
    B Razani
    Department of Molecular Pharmacology, Division of Hormone Dependent Tumor Biology, The Albert Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 108:1553-61. 2001
  36. ncbi Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy
    C Minetti
    Servizio Malattie Neuro Muscolari, Universita di Genova, Istituto Giannina Gaslini, Genoa, Italy
    Nat Genet 18:365-8. 1998
    ..b>Caveolins are the principal protein components of caveolae (50-100 nm invaginations found in most cell types) which ..
  37. ncbi Caveolins and cellular cholesterol balance
    E Ikonen
    Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Traffic 1:212-7. 2000
    b>Caveolins are major integral membrane components of caveolae. Over the last few years, evidence has accumulated for a close link between caveolin, caveolae, and the regulation of cellular cholesterol levels...
  38. ncbi Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation
    M L Lu
    Division of Urologic Surgery, Department of Surgery, Renal Division, Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:13442-51. 2001
    ..Using a mammalian two-hybrid assay system, we determine that the NH(2) terminus region of caveolin-1 is responsible for the interaction with both the NH(2)-terminal domain and the ligand-binding domain of AR...
  39. ncbi Role of caveolae and caveolins in health and disease
    Alex W Cohen
    Dept of Molecular Pharmacology and the Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Physiol Rev 84:1341-79. 2004
    ..That so many signaling molecules and signaling cascades are regulated by an interaction with the caveolins provides a paradigm by which numerous disease processes may be affected by ablation or mutation of these ..
  40. ncbi Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins
    K S Song
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 271:15160-5. 1996
    ..These results are consistent with previous immunoelectron microscopic studies demonstrating that dystrophin is localized to plasma membrane caveolae in smooth muscle cells...
  41. ncbi Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors
    X Feng
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    J Biol Chem 276:8341-9. 2001
    ..These findings suggest that intracellular distribution of activated TNF receptors may be regulated by caveolin-1 via its interaction with TRAF2...
  42. ncbi Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton
    Dorothy I Mundy
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    J Cell Sci 115:4327-39. 2002
    ..The behavior of cavicles suggests that they function as transport intermediates between caveolae and caveosomes...
  43. ncbi Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells
    Ayesha N Shajahan
    Department of Pharmacology, University of Illinois, College of Medicine, M C 868, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    J Biol Chem 279:20392-400. 2004
    ..Thus, Src-mediated phosphorylation of dynamin-2 is an essential requirement for scission of caveolae and the resultant transendothelial transport of albumin...
  44. ncbi Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy
    Takeharu Hayashi
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 313:178-84. 2004
    ..It was observed that the Thr63Ser mutation reduced the cell surface expression of caveolin-3, albeit the change was mild as compared with the LGMD mutations. These observations suggest that HCM is a clinical spectrum of CAV3 mutations...
  45. pmc A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes
    Mikko Karjalainen
    Department of Biological and Environmental Science Nanoscience Center, University of Jyvaskyla, FI 40351 Jyväskylä, Finland
    Mol Biol Cell 19:2857-69. 2008
    ..Our results together suggest that alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes...
  46. ncbi Caveolin scaffolding region and the membrane binding region of SRC form lateral membrane domains
    Stephen P Wanaski
    Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA
    Biochemistry 42:42-56. 2003
    ..Consequently, protein-induced membrane domains may affect cell signaling by organizing signal transduction components within the membrane and changing reaction rates...
  47. pmc Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport
    Eric J Smart
    Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 101:3450-5. 2004
    ..Pharmacological treatment of mice with ezetimibe disrupts the heterocomplex in only hypercholesterolemic animals. These data suggest that ANX2 and CAV1 are components of an intestinal sterol transport complex...
  48. ncbi The proprotein convertase furin colocalizes with caveolin-1 in the Golgi apparatus and endosomes of hepatocytes
    Gaetan Mayer
    Departement de pathologie et biologie cellulaire, Universite de Montreal, PO Box 6128, Montreal, Quebec, H3C 3J7, Canada
    Cell Tissue Res 316:55-63. 2004
    ..Our results suggest that, in addition to the Golgi, furin-/caveolin-1-containing endosomes could represent a compartment where furin processes its substrates at the basolateral domain of the hepatocyte...
  49. pmc Caveolins in vascular smooth muscle: form organizing function
    Christopher D Hardin
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Cardiovasc Res 69:808-15. 2006
    ..In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions of smooth muscle: contraction, growth/proliferation, and the ..
  50. pmc Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells
    Federica Sotgia
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 22:3905-26. 2002
    The relationship between glycosylphosphatidyl inositol (GPI)-linked proteins and caveolins remains controversial...
  51. pmc Impairment of caveolae formation and T-system disorganization in human muscular dystrophy with caveolin-3 deficiency
    Carlo Minetti
    Servizio Malattie Neuro Muscolari, Dipartimento di Pediatria, Universita di Genova, Istituto G Gaslini, Genova, Italy
    Am J Pathol 160:265-70. 2002
    ..These observations provide new perspectives in our understanding of the role of caveolin-3 in muscle and of the pathogenesis of muscle weakness in caveolin-3 deficient muscle...
  52. pmc Ligand-independent activation of oestrogen receptor alpha by caveolin-1
    A Schlegel
    Department of Molecular Pharmacology, The Albert Einstein Cancer Centre, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochem J 359:203-10. 2001
    ..Thus caveolin-1 is a novel ERalpha regulator that drives ERK1/2-independent phosphorylation and activation of AF-1...
  53. ncbi Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms
    Robert G Parton
    Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis, and School of Biomedical Sciences, University of Queensland, Queensland, 4072, Australia
    Traffic 4:724-38. 2003
    ..exquisite sensitivity to cholesterol-sequestering agents, can involve caveolae but also exist in cells devoid of caveolins and caveolae...
  54. ncbi Isoforms of caveolin-1 and caveolar structure
    T Fujimoto
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Cell Sci 113:3509-17. 2000
    ..When made to be expressed in HepG2 cells lacking endogenous caveolins, the alpha isoform formed caveolar depressions efficiently, but the beta isoform hardly did so...
  55. ncbi The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo
    K Das
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 274:18721-8. 1999
    The mammalian caveolin gene family consists of caveolins-1, -2, and -3. The expression of caveolin-3 is muscle-specific...
  56. pmc Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade
    David S Park
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biol Cell 13:3416-30. 2002
    ..In addition, the Ras-p42/44 MAPK cascade is hyper-activated. Because a similar premature lactation phenotype is observed in SOCS1 (-/-) null mice, we conclude that caveolin-1 is a novel suppressor of cytokine signaling...
  57. ncbi Hepatic overexpression of caveolins increases bile salt secretion in mice
    Mauricio Moreno
    Departamento de Gastroenterologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Hepatology 38:1477-88. 2003
    b>Caveolins are cholesterol-binding proteins involved in the regulation of several intracellular processes, including cholesterol transport...
  58. ncbi Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays
    Harriet Wikman
    Departments of Medical Genetics and Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
    J Pathol 203:584-93. 2004
    ..Some of these genes may provide novel diagnostic markers for lung cancer...
  59. ncbi Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic
    Lucas Pelkmans
    Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Cell 118:767-80. 2004
    ....
  60. ncbi Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo
    P E Scherer
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 272:29337-46. 1997
    ..purpose, we generated a novel mono-specific monoclonal antibody probe that recognizes only caveolin-2, but not caveolins-1 and -3...
  61. ncbi Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells
    L Li
    Scott Department of Urology, Baylor College of Medicine, 6560 Fannon, Houston, TX 77030, USA
    Cancer Res 61:4386-92. 2001
    ....
  62. pmc VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles
    T V Kurzchalia
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 118:1003-14. 1992
    ..The transiently expressed protein appeared on the Golgi-apparatus, the plasma membrane and vesicular structures. We propose that VIP21 is a component of the molecular machinery of vesicular transport...
  63. pmc Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization
    Paula Upla
    Cell Biology, University of Jyvaskyla, FIN 40351 Jyvaskyla, Finland
    Mol Biol Cell 15:625-36. 2004
    ..In addition to natural ligands human echovirus-1 (EV1) gains entry into the cell by binding to alpha 2 beta 1 and taking advantage of alpha 2 beta 1 internalization via caveolae...
  64. pmc Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol
    Lyne Labrecque
    Centre de cancérologie Charles Bruneau, Hopital Sainte Justine, Montreal, Quebec, Canada H3T 1C5
    Mol Biol Cell 14:334-47. 2003
    ..Overall, these results suggest that caveolin-1 plays multiple roles in the VEGF-induced signaling cascade...
  65. ncbi Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae
    D J Dietzen
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 270:6838-42. 1995
    ..Thus, palmitoylation of cysteine residues in nonmembrane spanning Src family protein tyrosine kinases has different consequences than in the transmembrane protein caveolin...
  66. ncbi Role of GTP hydrolysis in fission of caveolae directly from plasma membranes
    J E Schnitzer
    Department of Pathology, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA
    Science 274:239-42. 1996
    ..Thus, caveolae may bud to form discrete carrier vesicles that participate in membrane trafficking...
  67. pmc Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts
    J R Glenney
    Lucille P Markey Cancer Center, Lexington, KY
    Proc Natl Acad Sci U S A 89:10517-21. 1992
    ..This includes brightly fluorescent membrane patches in many cases concentrated at the margin of cells and in arrays. Caveolae may be distinct from other membrane domains due at least in part to caveolin...
  68. ncbi Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae
    Lucas Pelkmans
    Swiss Federal Institute of Technology Zurich ETHZ, HPM1 Building, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 296:535-9. 2002
    ..They were necessary for formation of caveolae-derived endocytic vesicles and for infection of the cell. Thus, caveolar endocytosis is ligand-triggered and involves extensive rearrangement of the actin cytoskeleton...
  69. ncbi Do caveolins regulate cells by actions outside of caveolae?
    Brian P Head
    Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
    Trends Cell Biol 17:51-7. 2007
    ..Recent work shows that caveolins can act independently of caveolae, both in cells that lack caveolae (e.g...
  70. ncbi Caveolae and caveolin-3 in muscular dystrophy
    F Galbiati
    Department of Pharmacology, University of Pittsburgh School of Medicine, Biomedical Science Tower (BST, Rm E1356, Pittsburgh, PA 15261, USA
    Trends Mol Med 7:435-41. 2001
    ..By contrast, upregulation of the caveolin-3 protein is associated with Duchenne muscular dystrophy (DMD). Thus, tight regulation of caveolin-3 appears essential for maintaining normal muscle health and homeostasis...
  71. pmc Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets
    A G Ostermeyer
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    J Cell Biol 152:1071-8. 2001
    ....
  72. ncbi Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette
    H Lee
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Endocrinol 14:1750-75. 2000
    ..We discuss the possible implications of our findings in the context of signal transduction...
  73. ncbi Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins
    Andrew J Halayko
    Canada Research Chair in Airway Cell and Molecular Biology, Department of Physiology, Section of Respiratory Disease, Health Sciences Centre, University of Manitoba, Winnipeg, MB, R3A 1R8 Canada
    Proc Am Thorac Soc 5:80-8. 2008
    ..This review summarizes mechanisms regulating ASM cell phenotype plasticity, and the role of caveolae as determinants of the functional diversity of ASM cells of a particular phenotypic state...
  74. ncbi The differential miscibility of lipids as the basis for the formation of functional membrane rafts
    A Rietveld
    European Molecular Biology Laboratory, Cell Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Biochim Biophys Acta 1376:467-79. 1998
    ..These domains are dynamic assemblies to which specific proteins are selectively sequestered while others are excluded. The proteins associated to rafts can act as organizers and can modulate raft size and function...
  75. ncbi Caveolin-1 peptide exerts cardioprotective effects in myocardial ischemia-reperfusion via nitric oxide mechanism
    L H Young
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Heart Circ Physiol 280:H2489-95. 2001
    ..These results provide evidence that caveolin-1 peptide significantly attenuated PMN-induced post-I/R cardiac contractile dysfunction in the isolated perfused rat heart, probably via enhanced release of endothelium-derived NO...
  76. ncbi Colocalization prostacyclin (PGI2) synthase--caveolin-1 in endothelial cells and new roles for PGI2 in angiogenesis
    E Spisni
    Department of Experimental Biology, University of Bologna, 40126 Bologna, Italy
    Exp Cell Res 266:31-43. 2001
    ....
  77. ncbi Modulation of the endothelial nitric-oxide synthase-caveolin interaction in cardiac myocytes. Implications for the autonomic regulation of heart rate
    O Feron
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:30249-54. 1998
    ..Thus, our results suggest that acylated eNOS may couple muscarinic receptor activation to heart rate control and indicate a key role for eNOS/caveolin interactions in the cholinergic modulation of cardiac myocyte function...
  78. ncbi Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains
    D Gingras
    Laboratoire d Oncologie Moléculaire Ste Justine UQAM, Departement de Chimie Biochimie, Universite du Quebec a Montreal, Canada
    Biochem Biophys Res Commun 247:888-93. 1998
    ..These findings may provide new insights into the functions played by Rho proteins and caveolae in signal transduction events...
  79. pmc Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation
    R T Watson
    Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    J Cell Biol 154:829-40. 2001
    ..These data demonstrate that the insulin stimulation of GLUT4 translocation in adipocytes requires the spatial separation and distinct compartmentalization of the PI-3 kinase and TC10 signaling pathways...
  80. ncbi Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria
    W P Li
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA
    J Cell Sci 114:1397-408. 2001
    ..We conclude that caveolin-1 can be targeted to a variety of intracellular destinations, which suggests a novel mechanism for the intracellular traffic of this protein...
  81. ncbi Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle
    Franco Capozza
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 288:C1317-31. 2005
    ..These findings may have clinical implications for the early diagnosis and treatment of caveolinopathies...
  82. ncbi Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer
    Daqing Wu
    Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, NC 27858, USA
    Cancer Res 62:2423-9. 2002
    ..This study provides several independent lines of evidence supporting the hypothesis that PKCepsilon expression may be sufficient to maintain prostate cancer growth and survival after androgen ablation...
  83. ncbi Membrane microdomains and caveolae
    T V Kurzchalia
    Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Opin Cell Biol 11:424-31. 1999
    ..several recent papers have suggested that caveolae, which are considered to be a specific form of raft, and caveolins, the major membrane proteins of caveolae, are involved in the dynamic cholesterol-dependent regulation of ..
  84. ncbi The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1
    Akiko Kimura
    Department of Medicine, Life Sciences Institute, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 277:30153-8. 2002
    ..Taken together, these data indicate that the insulin receptor directly catalyzes the tyrosine phosphorylation of caveolin...
  85. ncbi Cellular spelunking: exploring adipocyte caveolae
    Paul F Pilch
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    J Lipid Res 48:2103-11. 2007
    ....
  86. ncbi Internalization of cholera toxin by different endocytic mechanisms
    M L Torgersen
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Cell Sci 114:3737-47. 2001
    ..In conclusion, a large fraction of CT can be endocytosed by clathrin-dependent as well as by caveolae- and clathrin-independent endocytosis in different cell types...
  87. pmc Assembly of endocytic machinery around individual influenza viruses during viral entry
    Michael J Rust
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nat Struct Mol Biol 11:567-73. 2004
    ..CCP formation at these sites is much faster than elsewhere on the cell surface, suggesting a virus-induced CCP formation mechanism that may be commonly exploited by many other types of viruses...
  88. pmc Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis
    Guangwen Cao
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Pathol 162:1241-8. 2003
    ..These results demonstrate that disruption of the Cav1 gene promotes the progressive steps required for urinary calcium stone formation and establish a new mouse model for urinary stone disease...
  89. ncbi Polarization of caveolins and caveolae during migration of immortalized neurons
    D Lentini
    Department of Experimental Medicine, University of Milano Bicocca, Monza, Italy
    J Neurochem 104:514-23. 2008
    ..line of immortalized murine neurons (gonadotropin-releasing hormone expressing neurons; GN11), enriched with caveolins and caveolae invaginations that show in vitro chemotaxis upon serum exposure...
  90. pmc Scavenger receptor BI (SR-BI) clustered on microvillar extensions suggests that this plasma membrane domain is a way station for cholesterol trafficking between cells and high-density lipoprotein
    Yinan Peng
    Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Mol Biol Cell 15:384-96. 2004
    ..We speculate that SR-BI is in a more fluid membrane domain that will favor rapid cholesterol flux between the membrane and HDL...
  91. ncbi Altered expression of caveolin-1 and increased cholesterol in detergent insoluble membrane fractions from liver in mice with Niemann-Pick disease type C
    W S Garver
    Angel Charity for Children Wings for Genetic Research, Section of Medical and Molecular Genetics, The University of Arizona, College of Medicine, Tucson 85724, USA
    Biochim Biophys Acta 1361:272-80. 1997
    ....
  92. pmc Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes
    G Muller
    Aventis Pharma Germany, 65926 Frankfurt am Main, Germany
    Mol Cell Biol 21:4553-67. 2001
    ....
  93. ncbi Characterisation of caveolins from cartilage: expression of caveolin-1, -2 and -3 in chondrocytes and in alginate cell culture of the rat tibia
    W Schwab
    Institute of Anatomy, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Germany
    Histochem Cell Biol 112:41-9. 1999
    ..There is evidence that caveolin-2 and -3 are upregulated during growth and development of articular cartilage, suggesting a role for caveolins in chondrocyte differentiation.
  94. ncbi Smooth muscle excitation-contraction coupling: a role for caveolae and caveolins?
    M J Taggart
    Department of Medicine and Maternal and Fetal Health Research Centre, University of Manchester, Manchester Royal Infirmary, Manchester M13 9WL, England
    News Physiol Sci 16:61-5. 2001
    ..evidence suggests an important role for membranous invaginations termed caveolae, and their integral protein components caveolins, in the coordination of extracellular contractile stimuli and intracellular effectors in smooth muscle.
  95. doi Formation of N-type (Cav2.2) voltage-gated calcium channel membrane microdomains: Lipid raft association and clustering
    Philip Robinson
    Faculty of Life Sciences, University of Manchester, Core Technology Facility, Manchester, M13 9NT, United Kingdom
    Cell Calcium 48:183-94. 2010
    ..However, formation of clusters supporting "hotspots" of Ca(v) activity requires aggregation of macromolecular complexes containing raft components, stabilised by interactions with the cytoskeleton...
  96. ncbi Lipid rafts and insulin signaling
    Perry E Bickel
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 282:E1-E10. 2002
    ..Direct interactions between resident raft proteins (caveolins and flotillin-1) and insulin-signaling molecules may organize these molecules in space and time to ensure ..
  97. ncbi Multiple functions of caveolin-1
    Pingsheng Liu
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas 75235 9039, USA
    J Biol Chem 277:41295-8. 2002
  98. ncbi Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia
    Philippe G Frank
    Department of Molecular Pharmacology and the Albert Einstein Diabetes Research and Training Center DRTC, and Department of Urology, Albert Einstein College of Medicine, The Bronx, New York 10461, USA
    Curr Opin Lipidol 15:523-9. 2004
    ..These include endothelial cells, macrophages, and smooth muscle cells. Caveolae and caveolin-1 are involved in regulating several signal transduction pathways and processes that play an important role in atherosclerosis...
  99. ncbi T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin
    C D Wolfgang
    Laboratory of Molecular Biology, Division of Basic Sciences, National Cancer Institute, NIH, 37 Convent Drive, MSC 4255, Bethesda, MD 20892, USA
    Cancer Res 61:8122-6. 2001
    ..These results suggest that TARP has a role in regulating growth and gene expression in prostate cancer cells...
  100. ncbi Caveolae and caveolins in the cardiovascular system
    Jean Philippe Gratton
    Laboratory of Endothelial Cell Biology, Institut de Recherches Cliniques de Montreal, Canada
    Circ Res 94:1408-17. 2004
    Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many cellular processes, including transcytosis of macromolecules, cholesterol transport, and signal transduction...
  101. ncbi Ganglioside GM1 levels are a determinant of the extent of caveolae/raft-dependent endocytosis of cholera toxin to the Golgi apparatus
    Hao Pang
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Cell Sci 117:1421-30. 2004
    ....

Research Grants79

  1. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 1999
    ..The PI will introduce anti-sense constructs for Rab3A, Rab3D, caveolins 1, 2, and 3, PKC epsilon, PKC zeta, osteonectin, and adipocyte alpha3 VI collagen...
  2. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2002
    ..The PI will introduce anti-sense constructs for Rab3A, Rab3D, caveolins 1, 2, and 3, PKC epsilon, PKC zeta, osteonectin, and adipocyte alpha3 VI collagen...
  3. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2001
    ..The PI will introduce anti-sense constructs for Rab3A, Rab3D, caveolins 1, 2, and 3, PKC epsilon, PKC zeta, osteonectin, and adipocyte alpha3 VI collagen...
  4. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
    ..The PI will introduce anti-sense constructs for Rab3A, Rab3D, caveolins 1, 2, and 3, PKC epsilon, PKC zeta, osteonectin, and adipocyte alpha3 VI collagen...
  5. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2000
    ..The PI will introduce anti-sense constructs for Rab3A, Rab3D, caveolins 1, 2, and 3, PKC epsilon, PKC zeta, osteonectin, and adipocyte alpha3 VI collagen...
  6. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2002
    ..The PI will introduce anti-sense constructs for Rab3A, Rab3D, caveolins 1, 2, and 3, PKC epsilon, PKC zeta, osteonectin, and adipocyte alpha3 VI collagen...
  7. P2Y2 Purinergic Receptor and Membrane Microdomains
    Fernando Gonzalez; Fiscal Year: 2004
    ..Specific Aim 3: To test the hypothesis that membrane microdomain scaffolding molecules, caveolins and beta-arrestins, affect P2Y receptor coupling to signaling pathways...
  8. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2011
    ..Caveolae are specialized microdomains containing the structural proteins, caveolins that bind, organize and regulate receptors and signaling molecules involved in numerous cell functions including ..
  9. Analysis of the Spatiotemporal Regulation of Lipolysis
    Lisa M DiPilato; Fiscal Year: 2010
    ..In this proposal, I set out to elucidate signaling complexes formed by key scaffolding proteins, caveolins and A kinase anchoring proteins (AKAPs) at lipid droplets that organize the spatiotemporal regulation of ..
  10. CAVEOLAE AND CAVEOLINS IN C6 GLIAL CELL DIFFERENTIATION
    Walter Silva; Fiscal Year: 2001
    ..constitute an excellent model system for the study of the physiological relevance in glial cells of caveolae and caveolins. In addition, the ability to induce the differentiation of C6 cells into mature astrocytic cells permits the ..
  11. CAVEOLAE AND CAVEOLINS IN C6 GLIAL CELL DIFFERENTIATION
    Walter Silva; Fiscal Year: 2000
    ..constitute an excellent model system for the study of the physiological relevance in glial cells of caveolae and caveolins. In addition, the ability to induce the differentiation of C6 cells into mature astrocytic cells permits the ..
  12. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..My long-term goals are to study the pathways and the molecular mechanisms by which the caveolins are involved in IPF...
  13. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan Predescu; Fiscal Year: 2009
    ..My long-term goals are to study the pathways and the molecular mechanisms by which the caveolins are involved in IPF...
  14. Exercise as a novel strategy to target methamphetamine-induced cerebrovascular to
    MICHAL J TOBOREK; Fiscal Year: 2010
    ..We believe that the data obtained from this proposal will provide evidence that even moderate exercise can significantly contribute to brain regeneration in chronic cerebrovascular disorders. ..
  15. Exercise as a novel strategy to target methamphetamine-induced cerebrovascular to
    Michal Toborek; Fiscal Year: 2009
    ..We believe that the data obtained from this proposal will provide evidence that even moderate exercise can significantly contribute to brain regeneration in chronic cerebrovascular disorders. ..
  16. Structure/Function Modularity in Nitric Oxide Synthase
    Bettie Sue Masters; Fiscal Year: 2005
    ..co-crystallization and surface plasmon resonance techniques, to measure interactions with bradykinin receptors, caveolins, dynamin, and nostrin or their respective interactive domains; and 3) to identify and quantify the various ..
  17. Structure/Function Modularity in Nitric Oxide Synthase
    Bettie Sue Masters; Fiscal Year: 2006
    ..co-crystallization and surface plasmon resonance techniques, to measure interactions with bradykinin receptors, caveolins, dynamin, and nostrin or their respective interactive domains; and 3) to identify and quantify the various ..
  18. Structure/Function Modularity in Nitric Oxide Synthase
    Bettie Sue Masters; Fiscal Year: 2007
    ..co-crystallization and surface plasmon resonance techniques, to measure interactions with bradykinin receptors, caveolins, dynamin, and nostrin or their respective interactive domains; and 3) to identify and quantify the various ..
  19. Structure/Function Modularity in Nitric Oxide Synthase
    Bettie Sue Masters; Fiscal Year: 2004
    ..co-crystallization and surface plasmon resonance techniques, to measure interactions with bradykinin receptors, caveolins, dynamin, and nostrin or their respective interactive domains; and 3) to identify and quantify the various ..
  20. K Channel & c-Src Signaling Complexes in Smooth Muscle
    Enrico Stefani; Fiscal Year: 2004
    ..3 channels, 5-HT receptors, c-Src tyrosine kinase and caveolins, all critical regulators of SM function...
  21. K Channel & c-Src Signaling Complexes in Smooth Muscle
    Enrico Stefani; Fiscal Year: 2006
    ..3 channels, 5-HT receptors, c-Src tyrosine kinase and caveolins, all critical regulators of SM function...
  22. K Channel & c-Src Signaling Complexes in Smooth Muscle
    Enrico Stefani; Fiscal Year: 2005
    ..3 channels, 5-HT receptors, c-Src tyrosine kinase and caveolins, all critical regulators of SM function...
  23. K Channel & c-Src Signaling Complexes in Smooth Muscle
    Enrico Stefani; Fiscal Year: 2007
    ..3 channels, 5-HT receptors, c-Src tyrosine kinase and caveolins, all critical regulators of SM function...
  24. Cellular Signaling and Muscular Dystrophies
    THOMAS RANDO; Fiscal Year: 2003
    ..of muscular dystrophy are due to abnormalities of membrane proteins and protein complexes, such as integrins and caveolins, that are known to regulate cellular signaling pathways in general, and cell survival signaling in particular, ..
  25. Cellular Signaling and Muscular Dystrophies
    THOMAS RANDO; Fiscal Year: 2002
    ..of muscular dystrophy are due to abnormalities of membrane proteins and protein complexes, such as integrins and caveolins, that are known to regulate cellular signaling pathways in general, and cell survival signaling in particular, ..
  26. Cellular Signaling and Muscular Dystrophies
    THOMAS RANDO; Fiscal Year: 2005
    ..of muscular dystrophy are due to abnormalities of membrane proteins and protein complexes, such as integrins and caveolins, that are known to regulate cellular signaling pathways in general, and cell survival signaling in particular, ..
  27. Cellular Signaling and Muscular Dystrophies
    THOMAS RANDO; Fiscal Year: 2001
    ..of muscular dystrophy are due to abnormalities of membrane proteins and protein complexes, such as integrins and caveolins, that are known to regulate cellular signaling pathways in general, and cell survival signaling in particular, ..
  28. Cellular Signaling and Muscular Dystrophies
    THOMAS RANDO; Fiscal Year: 2004
    ..of muscular dystrophy are due to abnormalities of membrane proteins and protein complexes, such as integrins and caveolins, that are known to regulate cellular signaling pathways in general, and cell survival signaling in particular, ..
  29. Caveolins, Caveolae, and Lipid Rafts
    DOUGLAS LUBLIN; Fiscal Year: 2003
    ....
  30. Caveolins, Caveolae, and Lipid Rafts
    DOUGLAS LUBLIN; Fiscal Year: 2001
    ....
  31. Caveolins, Caveolae, and Lipid Rafts
    DOUGLAS LUBLIN; Fiscal Year: 2004
    ....
  32. Caveolins, Caveolae, and Lipid Rafts
    DOUGLAS LUBLIN; Fiscal Year: 2002
    ....
  33. Structure and Function of Membrane Rafts
    Deborah Brown; Fiscal Year: 2006
    ..There are three caveolin proteins in mammalian cells: caveolins-1, -2, and -3. Caveolins 1 and 2 are usually co-expressed, while caveolin-3 is restricted to muscle cells...
  34. Targeting and Trafficking of 5-HT2A serotonin Receptors
    Bryan Roth; Fiscal Year: 2006
    ..Specific Aim 2: To determine the relevance of 5-HT2A receptor interactions with caveolins-1 and flotillin, which target 5-HT2A receptors...
  35. Targeting and Trafficking of 5-HT2A serotonin Receptors
    Bryan Roth; Fiscal Year: 2007
    ..Specific Aim 2: To determine the relevance of 5-HT2A receptor interactions with caveolins-1 and flotillin, which target 5-HT2A receptors...
  36. Targeting and Trafficking of 5-HT2A serotonin Receptors
    Bryan Roth; Fiscal Year: 2009
    ..Specific Aim 2: To determine the relevance of 5-HT2A receptor interactions with caveolins-1 and flotillin, which target 5-HT2A receptors...
  37. Structure and Function of Membrane Rafts
    Deborah Brown; Fiscal Year: 2009
    ..There are three caveolin proteins in mammalian cells: caveolins-1, -2, and -3. Caveolins 1 and 2 are usually co-expressed, while caveolin-3 is restricted to muscle cells...
  38. Targeting and Trafficking of 5-HT2A serotonin Receptors
    Bryan Roth; Fiscal Year: 2006
    ..Specific Aim 2: To determine the relevance of 5-HT2A receptor interactions with caveolins-1 and flotillin, which target 5-HT2A receptors...
  39. Structure and Function of Membrane Rafts
    Deborah Brown; Fiscal Year: 2007
    ..There are three caveolin proteins in mammalian cells: caveolins-1, -2, and -3. Caveolins 1 and 2 are usually co-expressed, while caveolin-3 is restricted to muscle cells...
  40. Targeting and Trafficking of 5-HT2A serotonin Receptors
    Bryan Roth; Fiscal Year: 2005
    ..Specific Aim 2: To determine the relevance of 5-HT2A receptor interactions with caveolins-1 and flotillin, which target 5-HT2A receptors...
  41. Mechanical Signaling Mechanisms in Cardiac Tissue
    David E Dostal; Fiscal Year: 2011
    ..These studies will involve the role of caveolins and in mediating regulation of JNK and p381, as well as temporal regulation of the cross-talk mechanisms that ..
  42. Mechanical Signaling Mechanisms in Cardiac Tissue
    David E Dostal; Fiscal Year: 2010
    ..These studies will involve the role of caveolins and in mediating regulation of JNK and p381, as well as temporal regulation of the cross-talk mechanisms that ..
  43. Role of Caveolin Isoforms in PC12 Cell Differentiation
    Hector Maldonado; Fiscal Year: 2002
    ..differentiated phenotype, have been linked to or proposed to be regulated by CAV and its primary component caveolins. Recently, we have established the expression of all caveolin isoforms in C6 glial cell line and suggested a ..
  44. DEVELOPMENTAL REGULATION OF CYTOPLASMIC LIPID DROPLET SYNTHESIS
    JAMES MCMANAMAN; Fiscal Year: 2005
    ..The PAT family (Perilipin, Adipophilin, TIP47) of lipid droplet associated proteins and caveolins have been shown to play an essential role in the formation, stabilization and metabolism of lipid droplets in ..
  45. Adrenergic and Purinergic Regulation of Target Cells
    Paul A Insel; Fiscal Year: 2010
    ..MDCK and mpkCCD cells and assessment of sumoylation (a novel modification that we have recently identified) of caveolins;2) Functional roles of renal P2Y and adrenergic receptors using receptor-knockout mice...
  46. Adrenergic and Purinergic Regulation of Target Cells
    Paul Insel; Fiscal Year: 2009
    ..MDCK and mpkCCD cells and assessment of sumoylation (a novel modification that we have recently identified) of caveolins;2) Functional roles of renal P2Y and adrenergic receptors using receptor-knockout mice...
  47. Interactions of Na+/K+ ATPase with its signaling partners
    Zijian Xie; Fiscal Year: 2007
    ..Second, we shall test the hypothesis that caveolins are involved in assembly of the ouabain-activated signaling branches including those leading to the activationof ..
  48. Interactions of Na+/K+ ATPase with its signaling partners
    Zijian Xie; Fiscal Year: 2003
    ..Second, we shall test the hypothesis that caveolins are involved in assembly of the ouabain-activated signaling branches including those leading to the activationof ..
  49. Interactions of Na+/K+ ATPase with its signaling partners
    Zijian Xie; Fiscal Year: 2005
    ..Second, we shall test the hypothesis that caveolins are involved in assembly of the ouabain-activated signaling branches including those leading to the activationof ..
  50. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2010
    ..In this regard, the role of caveolae and caveolins in the lung is an exciting and emerging area of research...
  51. The Role of Caveolins in Lung Inflammation
    CHRISTINA PABELICK; Fiscal Year: 2009
    ..In this regard, the role of caveolae and caveolins in the lung is an exciting and emerging area of research...
  52. The Role of Caveolins in Lung Inflammation
    CHRISTINA PABELICK; Fiscal Year: 2009
    ..In this regard, the role of caveolae and caveolins in the lung is an exciting and emerging area of research...
  53. The Role of Caveolins in Lung Inflammation
    CHRISTINA PABELICK; Fiscal Year: 2009
    ..In this regard, the role of caveolae and caveolins in the lung is an exciting and emerging area of research...
  54. Pseudomonas invasion and the role of caveolin-2
    David Zaas; Fiscal Year: 2006
    ..unreadable] [unreadable] (End of Abstract) [unreadable] [unreadable] [unreadable]..
  55. Role of Caveolin in Scleroderma Tissue Fibrosis and Vasculopathy
    Sergio Jimenez; Fiscal Year: 2009
    ..Recent studies on idiopathic PAH and idiopathic pulmonary fibrosis identified caveolins as important participants in the pathogenesis of both diseases...
  56. Role of Caveolin in Scleroderma Tissue Fibrosis and Vasculopathy
    Sergio A Jimenez; Fiscal Year: 2010
    ..Recent studies on idiopathic PAH and idiopathic pulmonary fibrosis identified caveolins as important participants in the pathogenesis of both diseases...
  57. Implications of caveolae in Tat signaling and integrity of brain endothelium
    Michal Toborek; Fiscal Year: 2009
    ..localization of Tat to caveolae, the subset of lipid rafts characterized by the presence of proteins termed caveolins. The importance of this observation is related to the fact that a variety of cell surface receptors and ..
  58. Implications of caveolae in Tat signaling and integrity of brain endothelium
    MICHAL J TOBOREK; Fiscal Year: 2010
    ..localization of Tat to caveolae, the subset of lipid rafts characterized by the presence of proteins termed caveolins. The importance of this observation is related to the fact that a variety of cell surface receptors and ..
  59. Caveolae in Insulin Signaling
    CYNTHIA MASTICK; Fiscal Year: 2005
    ..the characterization of a unique insulin-stimulated signaling pathway that leads to tyrosine phosphorylation of caveolins-1 and -2, structural components of specialized cell surface domains termed caveolae...
  60. Caveolae in Insulin Signaling
    CYNTHIA MASTICK; Fiscal Year: 2006
    ..the characterization of a unique insulin-stimulated signaling pathway that leads to tyrosine phosphorylation of caveolins-1 and -2, structural components of specialized cell surface domains termed caveolae...
  61. Caveolae in Insulin Signaling
    CYNTHIA MASTICK; Fiscal Year: 2007
    ..the characterization of a unique insulin-stimulated signaling pathway that leads to tyrosine phosphorylation of caveolins-1 and -2, structural components of specialized cell surface domains termed caveolae...
  62. Caveolae in Insulin Signaling
    CYNTHIA MASTICK; Fiscal Year: 2004
    ..the characterization of a unique insulin-stimulated signaling pathway that leads to tyrosine phosphorylation of caveolins-1 and -2, structural components of specialized cell surface domains termed caveolae...
  63. Raft/Caveolar Mechanisms in Pulmonary Hypertension
    PRAVIN SEHGAL; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  64. Raft/Caveolar Mechanisms in Pulmonary Hypertension
    PRAVIN SEHGAL; Fiscal Year: 2005
    ....
  65. Raft/Caveolar Mechanisms in Pulmonary Hypertension
    PRAVIN SEHGAL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  66. Raft/Caveolar Mechanisms in Pulmonary Hypertension
    PRAVIN SEHGAL; Fiscal Year: 2003
    ....
  67. Raft/Caveolar Mechanisms in Pulmonary Hypertension
    PRAVIN SEHGAL; Fiscal Year: 2004
    ....
  68. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2001
    ..Specific aim 1 is to investigate the dual requirement for caveolins 1 and 2 in the apical targeting of GPI-anchored proteins by Fischer Rat Thyroid (FRT) cells...
  69. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2000
    ..Specific aim 1 is to investigate the dual requirement for caveolins 1 and 2 in the apical targeting of GPI-anchored proteins by Fischer Rat Thyroid (FRT) cells...
  70. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 1999
    ..Specific aim 1 is to investigate the dual requirement for caveolins 1 and 2 in the apical targeting of GPI-anchored proteins by Fischer Rat Thyroid (FRT) cells...
  71. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2002
    ..Specific aim 1 is to investigate the dual requirement for caveolins 1 and 2 in the apical targeting of GPI-anchored proteins by Fischer Rat Thyroid (FRT) cells...
  72. Caveolae and Anesthetic Induced Cardiac Protection
    David Roth; Fiscal Year: 2009
    ..b>Caveolins, proteins abundant in caveolae, provide a scaffold to organize, traffic and regulate signaling molecules...
  73. Caveolae and Anesthetic Induced Cardiac Protection
    David Roth; Fiscal Year: 2009
    ..b>Caveolins, proteins abundant in caveolae, provide a scaffold to organize, traffic and regulate signaling molecules...
  74. Caveolae and Anesthetic Induced Cardiac Protection
    David Roth; Fiscal Year: 2007
    ..b>Caveolins, proteins abundant in caveolae, provide a scaffold to organize, traffic and regulate signaling molecules...
  75. CAVEOLINS, SIGNALING AND CELL TRANSFORMATION
    Michael Lisanti; Fiscal Year: 2006
    ..endothelia vs. fatty stromal cells (mammary adipocytes), in the context of mammary tumorigenesis. ..
  76. CAVEOLINS, SIGNALING AND CELL TRANSFORMATION
    Michael Lisanti; Fiscal Year: 2005
    ..endothelia vs. fatty stromal cells (mammary adipocytes), in the context of mammary tumorigenesis. ..
  77. CAVEOLINS, SIGNALING AND CELL TRANSFORMATION
    Michael Lisanti; Fiscal Year: 2004
    ..endothelia vs. fatty stromal cells (mammary adipocytes), in the context of mammary tumorigenesis. ..
  78. CAVEOLINS, SIGNALING AND CELL TRANSFORMATION
    Michael Lisanti; Fiscal Year: 2006
    ..endothelia vs. fatty stromal cells (mammary adipocytes), in the context of mammary tumorigenesis. ..
  79. CAVEOLINS, SIGNALING AND CELL TRANSFORMATION
    Michael Lisanti; Fiscal Year: 2007
    ..endothelia vs. fatty stromal cells (mammary adipocytes), in the context of mammary tumorigenesis. ..