trka receptor

Summary

Summary: A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with congenital insensitivity to pain with anhidrosis, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

Top Publications

  1. ncbi Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
    C Wiesmann
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 401:184-8. 1999
  2. ncbi Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
    D R Kaplan
    Eukaryotic Signal Transduction Group, NCI Frederick Cancer Research and Development Center, Maryland 21701
    Nature 350:158-60. 1991
  3. ncbi The Chagas' disease parasite Trypanosoma cruzi exploits nerve growth factor receptor TrkA to infect mammalian hosts
    Milena de Melo-Jorge
    Parasitology Research Center, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Cell Host Microbe 1:251-61. 2007
  4. ncbi Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation
    T T Yeo
    Department of Neurology, University of California at San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 17:7594-605. 1997
  5. ncbi NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75(NTR) receptor
    Robert G Goold
    The MRC Centre for Developmental Neurobiology, King s College London, London, UK
    J Neurochem 87:935-46. 2003
  6. ncbi Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures
    Giuseppe Conti
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    Neurosci Res 65:201-9. 2009
  7. ncbi Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cells
    Chunhui Li
    Laboratory of Neural Signalling, The Robarts Research Institute, London, Ontario, Canada
    J Neurochem 112:882-99. 2010
  8. ncbi Survival of cholinergic forebrain neurons in developing p75NGFR-deficient mice
    C E Van der Zee
    Department of Anatomy and Neurobiology, Tupper Building, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Science 274:1729-32. 1996
  9. ncbi NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes
    Jonah R Chan
    Department of Neurobiology, Stanford University School of Medicine, Fairchild Science Building D235, CA 94305, USA
    Neuron 43:183-91. 2004
  10. ncbi NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination
    Xinhua Lee
    Department of Discovery Biology, Biogen Idec, Cambridge, Massachusetts 02142, USA
    J Neurosci 27:220-5. 2007

Research Grants

  1. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
  2. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
  3. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2009
  4. Remark bundle structure and function in neuropathic pain
    John Griffin; Fiscal Year: 2009
  5. Remark bundle structure and function in neuropathic pain
    John W Griffin; Fiscal Year: 2010
  6. Remark bundle structure and function in neuropathic pain
    John Griffin; Fiscal Year: 2009
  7. Specific targeting of a neuronal subset using a novel chimeric vector pseudotype
    CHRISTOPHER TRIMBY; Fiscal Year: 2007
  8. Nerve Growth Factor-Mechanisms for Signal Transduction
    William Mobley; Fiscal Year: 2007
  9. NGF RECEPTOR REGULATION OF PROSTATE GROWTH
    Daniel Djakiew; Fiscal Year: 2001
  10. Imaging nerve growth factor signal transduction in live neurons
    Bianxiao Cui; Fiscal Year: 2007

Detail Information

Publications184 found, 100 shown here

  1. ncbi Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
    C Wiesmann
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 401:184-8. 1999
    ....
  2. ncbi Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
    D R Kaplan
    Eukaryotic Signal Transduction Group, NCI Frederick Cancer Research and Development Center, Maryland 21701
    Nature 350:158-60. 1991
    ..Activation of the trk tyrosine kinase receptor provides a possible mechanism for signal transduction by NGF...
  3. ncbi The Chagas' disease parasite Trypanosoma cruzi exploits nerve growth factor receptor TrkA to infect mammalian hosts
    Milena de Melo-Jorge
    Parasitology Research Center, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Cell Host Microbe 1:251-61. 2007
    ..Thus, TrkA, the nerve growth factor receptor commonly associated with neural survival and protection, may also underlie clinical progression of an important human parasitic disease...
  4. ncbi Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation
    T T Yeo
    Department of Neurology, University of California at San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 17:7594-605. 1997
    ..These findings indicate that p75NTR negatively regulates cholinergic neuronal phenotype of the basal forebrain cholinergic neurons, including cell size, target innervation, and neurotransmitter synthesis...
  5. ncbi NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75(NTR) receptor
    Robert G Goold
    The MRC Centre for Developmental Neurobiology, King s College London, London, UK
    J Neurochem 87:935-46. 2003
    ..Finally, inhibition of TrkA receptor tyrosine kinase activity in PC12 cells and superior cervical ganglion neurons with K252a potently and dose-..
  6. ncbi Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures
    Giuseppe Conti
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    Neurosci Res 65:201-9. 2009
    ..The neuroprotective action of NGF is mediated by the TrkA receptor. This study determined whether repeated ECS exposure increased TrkA and NGF protein levels...
  7. ncbi Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cells
    Chunhui Li
    Laboratory of Neural Signalling, The Robarts Research Institute, London, Ontario, Canada
    J Neurochem 112:882-99. 2010
    Ectopic expression of the TrkA receptor tyrosine kinase in tumors of the nervous system can mediate nerve growth factor (NGF)-dependent cell death by apoptosis and /or autophagy...
  8. ncbi Survival of cholinergic forebrain neurons in developing p75NGFR-deficient mice
    C E Van der Zee
    Department of Anatomy and Neurobiology, Tupper Building, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Science 274:1729-32. 1996
    ..Apparently, p75(NGFR) mediates apoptosis of these developing neurons in the absence of TrkA, and modulation of p75(NGFR) can promote neuronal survival. Cholinergic basal forebrain neurons are involved in learning and memory...
  9. ncbi NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes
    Jonah R Chan
    Department of Neurobiology, Stanford University School of Medicine, Fairchild Science Building D235, CA 94305, USA
    Neuron 43:183-91. 2004
    ..These findings indicate a novel role for growth factors in regulating the receptivity of axons to myelination and reveal that different axonal signals control central and peripheral myelination...
  10. ncbi NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination
    Xinhua Lee
    Department of Discovery Biology, Biogen Idec, Cambridge, Massachusetts 02142, USA
    J Neurosci 27:220-5. 2007
    ..The implications of these results relate specifically to the development of potential therapeutics targeting extrinsic growth factors that may regulate the axonal expression of modulators of oligodendrocyte development...
  11. ncbi Oncogenic rearrangements of the NTRK1/NGF receptor
    Marco A Pierotti
    Department of Experimental Oncology and Labs Operative Unit 3, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milan, Italy
    Cancer Lett 232:90-8. 2006
    ..The modalities of their activation, their mechanism of action, the contribution of activating sequences, and the molecular mechanisms underlying their generation will be discussed...
  12. ncbi Origin and evolution of the Trk family of neurotrophic receptors
    Elia Benito-Gutiérrez
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, Barcelona E 08028, Spain
    Mol Cell Neurosci 31:179-92. 2006
    ..It is suggestive to propose that subtle protein mutations, gene duplications, and co-options in particular territories of a primitive Nt/Trk system were instrumental to the development of a complex vertebrate nervous system...
  13. ncbi Decreased first phase insulin response in children with congenital insensitivity to pain with anhidrosis
    Ruth Schreiber
    Pediatric Department, Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
    J Pediatr Endocrinol Metab 18:873-7. 2005
    ..Additional studies on the clinical significance of NGF-TrkA effects on insulin secretion are required...
  14. ncbi The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA
    Smita Saxena
    Abteilung Neuropathologie, Institut fur Pathologie, Universitat Bern, CH 3010 Bern, Switzerland
    J Neurosci 25:10930-40. 2005
    Nerve growth factor (NGF) and its TrkA receptor exert important bioactivities on neuronal cells such as promoting survival and neurite outgrowth...
  15. ncbi Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes
    Angela Raucci
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Biol Chem 279:1747-56. 2004
    ..These results indicate that inhibition of chondrocyte proliferation by FGF requires both ERK1/2 and p38 MAPK signaling and also suggest that sustained activation of these pathways is required to achieve growth inhibition...
  16. ncbi Nerve growth factor activates persistent Rap1 signaling in endosomes
    C Wu
    Departments of Neurology and Neurological Sciences and of Pediatrics and the Program in Neuroscience, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:5406-16. 2001
    ..We propose that endosomes are a site from which NGF induces the prolonged activation of Rap1 and MAPK...
  17. ncbi Neurotrophin signalling in health and disease
    Moses V Chao
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Clin Sci (Lond) 110:167-73. 2006
    ..In this review, we consider the signalling pathways activated by neurotrophins in both health and disease states...
  18. ncbi Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain
    Chih Li Chen
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Neuron 49:365-77. 2006
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy...
  19. ncbi Molecular genetics of hereditary sensory neuropathies
    Michaela Auer-Grumbach
    Department of Internal Medicine, Medical Research Center, Medical University of Graz, Stiftingtalstrasse 24, A 8010 Graz, Austria
    Neuromolecular Med 8:147-58. 2006
    ..Nevertheless, it remains unclear how mutations in the known genes lead to the phenotype of HSN. In this review, we summarize the recent progress of the molecular genetics of the HSN and the implicated genes...
  20. ncbi Quantum dots monitor TrkA receptor dynamics in the interior of neural PC12 cells
    Sujata Sundara Rajan
    Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006 8921, USA
    Nano Lett 6:2049-59. 2006
    ..QDs are contained in microtubule-associated vesicles and possess transport properties that reflect TrkA receptor dynamics...
  21. ncbi Neurotrophic factor expression in childhood low-grade astrocytomas and ependymomas
    Antonio Chiaretti
    Paediatric Intensive Care Unit, Catholic University of Sacred Heart, 00168 Rome, Italy
    Childs Nerv Syst 20:412-9. 2004
    ..In accordance with the role of neurotrophic factors in tumour behaviour the aim of the present study was to investigate their expression in two childhood brain neoplasms, namely low-grade astrocytomas and ependymomas...
  22. ncbi On Trk for retrograde signaling
    F D Miller
    Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, H3A 2B4, Montreal, Quebec, Canada
    Neuron 32:767-70. 2001
    ....
  23. ncbi TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma
    Antonella Tacconelli
    Department of Experimental Medicine, University of L Aquila, Via Vetoio, Coppito 2, 67100 L Aquila, Italy
    Cancer Cell 6:347-60. 2004
    ....
  24. ncbi Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes
    F Iannone
    Rheumatology Unit, DIMIMP, Italy
    Rheumatology (Oxford) 41:1413-8. 2002
    ..We can speculate that NGF, like other growth factors, stimulates chondrocyte metabolism in the osteoarthritic process...
  25. ncbi Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules
    Takeshi Nakamura
    Department of Molecular Genetics, National Institute for Longevity Sciences, Program of Protecting the Brain, CREST, JST, Oobu, Aichi 474 8522, Japan
    Mol Cell Biol 22:8721-34. 2002
    ..These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases...
  26. ncbi Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation
    Jerome Jullien
    Differentiation and Cell Cycle Group, Laboratoire de Biologie Moleculaire et Cellulaire, UMR 5665 CNRS, Ecole Normale Superieure de Lyon, France
    J Biol Chem 278:8706-16. 2003
    ..This approach and the fidelity of the biochemical properties of the TrkA-GFP demonstrate that real-time visualization of trafficking of tyrosine kinase receptors in the presence or absence of the ligand is feasible...
  27. ncbi NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals
    Jean Dominique Delcroix
    Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, USA
    Neuron 39:69-84. 2003
    ..Our results are evidence that signaling endosomes, with the characteristics of early endosomes, convey NGF signals from the target of nociceptive neurons to their cell bodies...
  28. ncbi Neurotrophic activities of trk receptors conserved over 600 million years of evolution
    Gad Beck
    Department of Biological Chemistry, Molecular Neurobiology Group, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurobiol 60:12-20. 2004
    ..Thus, Ltrk is required for neuronal survival, suggesting that trophic activities of the trk receptor family originated before the divergence of molluscan and vertebrate lineages approximately 600 million years ago...
  29. ncbi Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa
    Laura Lenzi
    Institute of Neurobiology and Molecular Medicine, Neurobiology Section, CNR, Viale Marx 43/15, 00137 Rome, Italy
    Vision Res 45:1491-500. 2005
    ..This suggests that NGF has an effect on RCS rat retina, probably also through the stimulation of other biological mediators produced and released in the retina...
  30. ncbi Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth
    Yasuhiro Indo
    Department of Pediatrics, Kumamoto University School of Medicine, Japan
    Clin Auton Res 12:I20-32. 2002
    ..cause CIPA, the molecular pathology of CIPA provides unique opportunities to explore critical roles of the NGF-TRKA receptor system...
  31. ncbi Intraocular production and release of nerve growth factor after iridectomy
    Alessandro Lambiase
    Department of Ophthalmology, University of Rome Tor Vergata, Rome, Italy
    Invest Ophthalmol Vis Sci 43:2334-40. 2002
    ..Experimental iridectomy induces increased production of NGF in the iris and in the ciliary body and an increased concentration of NGF in the aqueous humor...
  32. ncbi Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment
    M Rihl
    Hannover Medical School MHH, Department of Rheumatology OE 6850, Carl Neuberg Str 1, 30625 Hannover, Germany
    Ann Rheum Dis 64:1542-9. 2005
    ..To investigate whether expression of the four members of the neurotrophin (NT) family and their four corresponding receptors is related to synovial inflammation in patients with spondyloarthritis (SpA).Material and..
  33. ncbi Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
    Kwang Mook Jung
    Department of Pathology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Biol Chem 278:42161-9. 2003
    ..our studies suggest that gamma-secretase-mediated p75NTR proteolysis plays a role in the formation/disassembly of the p75-TrkA receptor complex by regulating the availability of the p75 TM domain that is required for this interaction.
  34. ncbi Remodeling of the innervation of pancreatic islets accompanies insulitis preceding onset of diabetes in the NOD mouse
    Solveig Persson-Sjögren
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
    J Neuroimmunol 158:128-37. 2005
    ....
  35. ncbi Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor
    Y Indo
    Department of Pediatrics, Kumamoto University School of Medicine, Kumamoto, Japan
    Hum Mutat 18:462-71. 2001
    ..Defects in NGF signal transduction at the TRKA receptor lead to failure to support survival of sympathetic ganglion neurons and nociceptive sensory neurons derived ..
  36. ncbi Recent advances in hereditary sensory and autonomic neuropathies
    Kristien Verhoeven
    Peripheral Neuropathy Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Curr Opin Neurol 19:474-80. 2006
    ..SUMMARY: This review will discuss each of the different loci and genes of these disorders, showing glimpses into a possible underlying pathomechanism leading to the degeneration of sensory and autonomic neurons...
  37. ncbi Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function
    Yolanda de Pablo
    Cell Signaling and Apoptosis Group, Department Ciències Médiques Bàsiques, IRBLLEIDA, Lleida, Spain
    J Neurochem 104:124-39. 2008
    ..This is the first evidence that a Tyr residue can simultaneously regulate TrkA receptor trafficking and activity.
  38. ncbi Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity
    N Y Ip
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591
    Proc Natl Acad Sci U S A 89:3060-4. 1992
    ..However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4...
  39. ncbi Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor
    A Chittka
    Cell Biology Program, Weill Graduate School of Cornell University Medical College, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:10705-10. 1999
    ..The translocation of SC-1 to the nucleus was specific for p75, as NGF binding to the TrkA receptor did not lead to nuclear localization of SC-1...
  40. ncbi Nerve growth factor helps protect retina in experimental retinal detachment
    Xiaodong Sun
    Eye Research Institute of Shanghai JiaoTong University, Shanghai, China
    Ophthalmologica 222:58-61. 2008
    ..To investigate the expression of nerve growth factor (NGF) and its receptor TrkA on the retina at different time points after retinal detachment (RD) and the protection effect of NGF in experimental RD...
  41. ncbi Rapid physical mapping of the human trk protooncogene (NTRK1) to human chromosome 1q21-q22 by P1 clone selection, fluorescence in situ hybridization (FISH), and computer-assisted microscopy
    H U Weier
    Center for Molecular Cytogenetics, Lawrence Berkeley Laboratory, Berkeley, California 94720, USA
    Genomics 26:390-3. 1995
    ..The scheme presented here can easily be generalized to map physically very small nonrepetitive genomic DNA fragments or incomplete cDNAs...
  42. ncbi The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor
    S Pollack
    Department of Biochemistry, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, United Kingdom
    Mol Pharmacol 56:185-95. 1999
    ..Because L-753, 000 selectively potentiates the NT-3-induced stimulation of TrkA without inhibiting Trks and other protein kinases, it represents a novel class of selective modifiers of neurotrophin actions...
  43. ncbi POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression
    E J Huang
    Program in Neuroscience, Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0723 USA
    Development 126:2869-82. 1999
    ..In conclusion, our data indicate the specific functions of Brn-3a in controlling the survival and differentiation of trigeminal neurons by regulating expression of each of the three Trk receptors...
  44. ncbi Nerve growth factor induces vascular endothelial growth factor expression in granulosa cells via a trkA receptor/mitogen-activated protein kinase-extracellularly regulated kinase 2-dependent pathway
    Marcela Julio-Pieper
    Laboratorio de Endocrinología y Biología de la Reproducción, Hospital Clinico Universidad de Chile, Santos Dumont 999 Independencia, Santiago, Chile
    J Clin Endocrinol Metab 94:3065-71. 2009
    ..Nerve growth factor (NGF) may be one of these factors, because NGF promotes angiogenesis and synthesis of angiogenic factors in other tissues and is produced by human granulosa cells (hGCs)...
  45. ncbi Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression
    J H Lin
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 95:393-407. 1998
    ..ETS genes may therefore participate in the development of selective sensory-motor circuits in the spinal cord...
  46. ncbi Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo
    I Farinas
    Department of Physiology, University of California, San Francisco 94143, USA
    Neuron 21:325-34. 1998
    ..Results also indicate that survival of cells expressing both receptors can be maintained by activation of either one alone. NT-3 can thus activate more than one Trk receptor in vivo, which when coexpressed are functionally redundant...
  47. ncbi Humoral immunodeficiency in congenital insensitivity to pain with anhidrosis
    Sara Sebnem Kilic
    Department of Pediatric Immunology, Uludag University School of Medicine, Gorukle, Bursa, 16059, Turkey
    Neurogenetics 10:161-5. 2009
    ..The implication of the immune system of the reported patient broadens the clinical phenotype associated with NTRK1 mutations...
  48. ncbi Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma
    Marco Coassin
    CIR, Laboratory of Ophthalmology, University Campus Bio Medico, Via Alvaro del Portillo, 21, 00128, Rome, Italy
    Graefes Arch Clin Exp Ophthalmol 246:1743-9. 2008
    ..Therefore, this study sought to address whether timely changes in NGF and its receptors, trkA(NGFR) and p75(NTR), might explain the progression of retinal damage during experimental glaucoma...
  49. ncbi Expression of NGF, Trka and p75 in human cartilage
    A Gigante
    Clinica Ortopedica, Universita di Ancona, Via Tronto 10, 60020 Torrette di Ancona, Italy
    Eur J Histochem 47:339-44. 2003
    ....
  50. ncbi Neural crest development and neuroblastoma: the genetic and biological link
    Akira Nakagawara
    Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Prog Brain Res 146:233-42. 2004
    ..Thus, the enigmatic clinical behaviors of neuroblastoma are strictly linked to the molecular mechanism of neural crest development...
  51. ncbi Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation
    Y Zhang
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 20:5671-8. 2000
    ..Thus, interactions between Trk receptor tyrosine kinases and intracellular signaling molecules are dictated both by phosphotyrosine motifs within the receptors and by the intracellular location of phosphorylated receptors...
  52. ncbi Distinct effects of p75 in mediating actions of neurotrophins on basal forebrain oligodendrocytes
    Yangzhou Du
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Mol Cell Neurosci 31:366-75. 2006
    ..On the other hand, K252a, an inhibitor of trk receptors, abolished the effects of the neurotrophins, including BDNF. All neurotrophins activated their respective trk receptors...
  53. ncbi Runx1 selectively regulates cell fate specification and axonal projections of dorsal root ganglion neurons
    Masaaki Yoshikawa
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8577, Japan
    Dev Biol 303:663-74. 2007
    ..Our results suggest that Runx1 is involved in the cell fate specification of cutaneous neurons, as well as their projections to central and peripheral targets...
  54. ncbi IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1
    C Miranda
    INSERM Unité 145 and IFR 50, Faculte de Medecine, Nice, France
    J Cell Physiol 186:35-46. 2001
    ..Here, we show that IRS-1 and IRS-2 are phosphorylated on tyrosine in presence of both TRK-T1 and the activated TrkA receptor. These tyrosine phosphorylations lead to IRS-1- and IRS-2-induced recruitment of p85PI3K, SHP-2, and Grb2 and ..
  55. ncbi The p75 neurotrophin receptor: multiple interactors and numerous functions
    Jannifer J Gentry
    Center for Molecular Neuroscience, Department of Biochemistry, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Prog Brain Res 146:25-39. 2004
    ..Here, we review these p75NTR interacting factors and the current evidence as to how they contribute to the functional effects of p75NTR activation...
  56. ncbi Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells
    Yumiko Abe
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago IL, USA
    Spine (Phila Pa 1976) 32:635-42. 2007
    ..In vitro studies of the effects of proinflammatory cytokines on the production of nerve growth factor (NGF) by human intervertebral disc (IVD) cells...
  57. ncbi NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis
    A H Salehi
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada
    Neuron 27:279-88. 2000
    ..Our results show that NRAGE contributes to p75NTR-dependent cell death and suggest novel functions for MAGE family proteins...
  58. ncbi Molecular characterization of the TrkA/NGF receptor minimal enhancer reveals regulation by multiple cis elements to drive embryonic neuron expression
    L Ma
    Center for Developmental Biology, UT Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Development 127:3777-88. 2000
    ..These results provide a foundation for identification of the transcriptional machinery that specifies neurotrophin receptor expression...
  59. ncbi High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
    B L Hempstead
    Department of Medicine, Cornell University Medical College, New York, New York 10021
    Nature 350:678-83. 1991
    ..These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor...
  60. ncbi TrkA receptor "hot spots" for binding of NT-3 as a heterologous ligand
    Ljubica Ivanisevic
    Lady Davis Institute Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 282:16754-63. 2007
    ..This study demonstrates that Trk signaling is more complex than previously thought because it involves several receptor subdomains and hot spots...
  61. ncbi Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies
    S Shatzky
    Genetics Institute, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel
    Am J Med Genet 92:353-60. 2000
    ..Three polymorphisms in the TrkA protein kinase encoding domain were also observed...
  62. ncbi The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
    S X Bamji
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Cell Biol 140:911-23. 1998
    ..Together, these data indicate that p75NTR can signal to mediate apoptosis, and that this mechanism is essential for naturally occurring sympathetic neuron death...
  63. ncbi Pacinian corpuscle development involves multiple Trk signaling pathways
    J Sedy
    Institute of Anatomy, Charles University, First Faculty of Medicine, U nemocnice 3, 128 00 Prague, Czech Republic
    Dev Dyn 231:551-63. 2004
    ..In addition, NT3/TrkB and/or NT3/TrkA signaling plays a greater role than NT3/TrkC signaling in afferents to developing Pacinian corpuscles...
  64. ncbi Differences in the surface binding and endocytosis of neurotrophins by p75NTR
    Smita Saxena
    Division of Neuropathology, Institute of Pathology, University of Bern, CH-3010 Bern, Switzerland
    Mol Cell Neurosci 26:292-307. 2004
    ..Our results suggest that p75NTR may have multiple roles in different subcellular locations, functioning both at the cell surface and also within endocytic compartments...
  65. ncbi Suppression of neurite outgrowth by high-dose nerve growth factor is independent of functional p75NTR receptors
    Anna M Conti
    Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Neurobiol Dis 15:106-14. 2004
    ..Inhibition could be mediated by either the p75NTR or TrkA receptor. We used a functional block of p75NTR by REX antibody in rat dorsal root ganglion neurons and dorsal root ..
  66. ncbi Nerve growth factor receptor-mediated gene transfer
    Nan Ma
    Institute of Bioengineering and Nanotechnology, Singapore
    Mol Ther 9:270-81. 2004
    ..These properties make the chimeric peptide a promising gene delivery vector for targeting specific subtypes of neurons...
  67. ncbi Sortilin is essential for proNGF-induced neuronal cell death
    Anders Nykjaer
    Department of Medical Biochemistry, Ole Worms Alle 170, Aarhus University, Gustav Wieds Vej 10, DK 8000 Aarhus C, Denmark
    Nature 427:843-8. 2004
    ..Here we report that proNGF creates a signalling complex by simultaneously binding to p75NTR and sortilin. Thus sortilin acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGF...
  68. ncbi TrkA and mitogen-activated protein kinase phosphorylation are enhanced in sympathetic neurons lacking functional p75 neurotrophin receptor expression
    Sari S Hannila
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Eur J Neurosci 19:2903-8. 2004
    ..These data provide new insight into the mechanism underlying enhanced neurite outgrowth in p75(-/-) neurons, demonstrating that trkA and MAPK signalling in sympathetic neurons are increased when p75NTR function is disrupted...
  69. ncbi Inhibition of neuronal phenotype by PTEN in PC12 cells
    Sergei Musatov
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:3627-31. 2004
    ..Our findings may shed new light on the role of this tumor suppressor during normal brain development and suggest a previously uncharacterized mechanism of PTEN action in neuron-like cells...
  70. ncbi The p75 neurotrophin receptor enhances TrkA signalling by binding to Shc and augmenting its phosphorylation
    W Ruwan Epa
    Physiology Department, University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 89:344-53. 2004
    ..Whilst providing evidence that p75(NTR) augments TrkA signal transduction, these results do not preclude the presence of a p75(NTR)-TrkA high-affinity NGF receptor...
  71. ncbi Differential change in mRNA expression of p75 and Trk neurotrophin receptors in nucleus gracilis after spinal nerve ligation in the rat
    Virginia M Goettl
    Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, S 2056 William H Davis Medical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Exp Neurol 187:533-6. 2004
    ..Decreased Trk mRNA may result in decreased NT activity in the NuGr. The p75 receptor influences Trk activity and cell survival, thus its role in PN warrants further investigation...
  72. ncbi Nestin-expressing neural stem cells identified in the scar following myocardial infarction
    Jessica Drapeau
    Department of Physiology, University of Montreal, Montreal, Quebec, Canada
    J Cell Physiol 204:51-62. 2005
    ..These data highlight the novel observation that neural stem cells were recruited to the infarct region of the damaged rat heart and may contribute in part to nerve fiber growth and subsequent innervation of the scar...
  73. ncbi Study of expression patterns and levels of neurotrophins and neurotrophin receptors in ulcerative colitis
    Malin Johansson
    Department of Integrative Medical Biology, Section of Anatomy, Umea University, Umea, Sweden
    Inflamm Bowel Dis 13:398-409. 2007
    ..Neurotrophins may be involved in ulcerative colitis (UC). Yet, it is unclear whether if their effects should be blocked...
  74. ncbi The expression of neurotrophins and their receptors in the prenatal and adult human testis: evidence for functions in Leydig cells
    Dieter Muller
    Institute for Hormone and Fertility Research, University of Hamburg, Falkenried 88, 20251 Hamburg, Germany
    Histochem Cell Biol 126:199-211. 2006
    ....
  75. ncbi Expression of neurotrophic factors in neonatal rats after peripheral inflammation
    Chih Cheng Chien
    Department of Medicine, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    J Pain 8:161-7. 2007
    ..This work provided further detailed information about possible neurotransmitters and peptides involved in this process. This might also lead to future clinical application...
  76. ncbi Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?
    Grant D Nicol
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Interv 7:26-41. 2007
    ..Furthermore, controversy exists as to the downstream signaling pathways involved in NGF-induced peripheral sensitization...
  77. ncbi Neurotrophin-3 administration alters neurotrophin, neurotrophin receptor and nestin mRNA expression in rat dorsal root ganglia following axotomy
    L T Kuo
    Department of Molecular Neuroscience, Division of Neuropathology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroscience 147:491-507. 2007
    ..These data suggest that systemically administered NT-3 may counteract the decrease, or even increase, neurotrophin responsiveness in both ipsi- and contralateral ganglia after nerve injury...
  78. ncbi Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines
    Harald Stephan
    Department of Pediatric Hematology, Oncology and Endocrinology, University Hospital of Essen, Essen, Germany
    Pediatr Blood Cancer 50:218-22. 2008
    ..Expression of Trk receptors has been implicated in the pathogenesis and prognosis of embryonal tumors, including neuroblastoma, nephroblastoma, and medulloblastoma...
  79. ncbi A model for neuronal competition during development
    Christopher D Deppmann
    Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 320:369-73. 2008
    ..We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects...
  80. ncbi Inflammation causes expression of NGF in epithelial cells of the rat colon
    Roger D P Stanzel
    Gastrointestinal Diseases Research Unit, Queens University, Kingston, Ontario, Canada
    Exp Neurol 211:203-13. 2008
    ..We conclude that NGF is principally synthesized by epithelial cells in the inflamed colon, where the presence of specific receptors suggests the potential for wide-spread action...
  81. ncbi p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation
    Joe P S Makkerh
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada
    EMBO Rep 6:936-41. 2005
    ..Coexpression of p75 NTR attenuated ubiquitination of TrkA and TrkB and delayed nerve growth factor-induced TrkA receptor internalization and receptor degradation...
  82. ncbi Nerve growth factor sensitivity is broadly distributed among myenteric neurons of the rat colon
    Agueda Lin
    Gastrointestinal Diseases Research Unit, Queen's University, Hotel Dieu Hospital, 166 Brock Street, Kingston, Ontario K7L 5G2, Canada
    J Comp Neurol 490:194-206. 2005
    ..We conclude that functional receptors for NGF are widely distributed among the diverse enteric phenotypes and argue for a novel NGF-mediated regulatory system within the ENS...
  83. ncbi Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro
    E Gascon
    Department of Neuroscience, University of Geneva Medical School, 1 rue Michel Servet, CH 1211, Geneva, Switzerland
    Eur J Neurosci 21:69-80. 2005
    ....
  84. ncbi The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC
    B Fayard
    Division of Neuropathology, Institute of Pathology, University of Bern, Bern, Switzerland
    J Neurosci Res 80:18-28. 2005
    ..Taken together, these data indicate that pro-BDNF binds to and activates TrkB and could be involved in TrkB-mediated neurotrophic activity in vivo...
  85. ncbi Multiple acute effects on the membrane potential of PC12 cells produced by nerve growth factor (NGF)
    Kazuhiro Shimazu
    Section on Growth Factors, NICHD, National Institutes of Health (NIH, Maryland, USA
    J Cell Physiol 203:501-9. 2005
    ..These results suggest that three different currents are implicated in rapid NGF-induced membrane voltage changes, namely an acutely activated Na+ current, Ca2+-dependent potassium currents and non-selective cation currents...
  86. ncbi Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking
    Smita Saxena
    Division of Neuropathology, Institute of Pathology, University of Bern, CH 3010 Bern, Switzerland
    Mol Cell Neurosci 28:571-87. 2005
    ..Disrupting p75NTR recycling diminished TrkA activation in response to low concentrations of NGF, demonstrating a functional role for the recycling of p75NTR...
  87. ncbi p75NTR-mediated signaling promotes the survival of myoblasts and influences muscle strength
    Shailaja Reddypalli
    Department of Biology, University of Texas at San Antonio, 78249, USA
    J Cell Physiol 204:819-29. 2005
    ..Taken together, the data indicate that the p75(NTR) mediates survival of myoblasts prior to differentiation and that the activity of this receptor during myogenesis is important for developing muscle...
  88. ncbi Direct, complex effects of estrogens on basal forebrain cholinergic neurons
    Susan H Bora
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Exp Neurol 194:506-22. 2005
    ..Our findings support the idea that estrogens directly enhance cholinergic neuron function and that ERalpha plays a significant role in transducing these regulatory effects...
  89. ncbi TrkA NGF receptor plays a role in the modulation of p75NTR expression
    Sherri L Rankin
    Division of Basic Medical Sciences-M5352, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Phillip Drive, St. John's, Nfld, Canada A1B 3V6
    Neurosci Lett 383:305-10. 2005
    ..Together these results indicate a role for the individual tyrosine autophosphorylation sites of TrkA in regulating p75NTR expression...
  90. ncbi P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1
    Zeljka Korade Mirnics
    Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neurobiol Dis 20:969-85. 2005
    ....
  91. ncbi Neurotrophin-induced upregulation of p75NTR via a protein kinase C-delta-dependent mechanism
    Sherri L Rankin
    Division of Biomedical Sciences, Memorial University of Newfoundland, St John s NL, Canada
    Brain Res 1217:10-24. 2008
    ....
  92. ncbi Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors
    E Woodhall
    Department of Anatomy and Physiology, University of Tasmania, P.O. Box 252-24, Hobart, Tasmania 7001, Australia
    Brain Res Mol Brain Res 88:203-13. 2001
    ..The results of the experiments show that ECs express a number of growth factors and that BDNF in particular could act both in a paracrine and autocrine manner...
  93. ncbi Amelioration of cholinergic neurons dysfunction in aged rats depends on the continuous supply of NGF
    Grazyna Niewiadomska
    Department of Neurophysiology, Nencki Institute, 3 Pasteur St, 02 093 Warsaw, Poland
    Neurobiol Aging 23:601-13. 2002
    ..NGF may be beneficial in enhancing cholinergic neurochemical parameters, but the protective effects seem to be dependent on the continuous supply of NGF...
  94. ncbi Molecular kinetics of nerve growth factor receptor trafficking and activation
    Jerome Jullien
    Differentiation and Cell Cycle Group, Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UMR 5665, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Biol Chem 277:38700-8. 2002
    ..Together, these data show that the primary effect of NGF treatment is a p75(NTR)-modulated decrease in TrkA transit time at the cell surface...
  95. ncbi p75 neurotrophin receptor is required for constitutive and NGF-induced survival signalling in PC12 cells and rat hippocampal neurones
    Nguyen Truc Bui
    Interdisciplinary Center for Clinical Research, Research Group 'Apoptosis and Cell Death, Faculty of Medicine, Westphalian Wilhelms-University, , Germany
    J Neurochem 81:594-605. 2002
    ..Our data suggest that the p75 neurotrophin receptor mediates constitutive and NGF-induced survival signalling in PC12 cells and hippocampal neurones, and that these effects are mediated via the PI3-kinase pathway...
  96. ncbi Role of low-affinity p75 receptor in nerve growth factor-inducible growth arrest of PC12 cells
    Hisanori Ito
    Laboratory of Molecular Biology, Gifu Pharmaceutical University, Gifu, Japan
    J Neurosci Res 69:653-61. 2002
    ..Our results suggest that NGF signaling via TrkA affects the differentiation characteristics of PC12 cells but that an additional signaling via p75 is necessary for the growth arrest of the cells...
  97. ncbi Neurotrophins and their receptors in early axonal regeneration along muscle-vein-combined grafts
    Alessia Pagnotta
    Istituto di Clinica Ortopedica, , Ancona, Italy
    Microsurgery 22:300-3. 2002
    ....
  98. ncbi Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75
    C Culmsee
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Ketzerbach 63, 35032, Marburg, Germany
    Neuroscience 115:1089-108. 2002
    ..Overall, our results indicate an essential role for p75NTR in supporting NGF-triggered TrkA signaling pathways mediating neuronal survival in hippocampal neurons...
  99. ncbi Retinoic acid combined with neurotrophin-3 enhances the survival and neurite outgrowth of embryonic sympathetic neurons
    L A Plum
    Interdepartmental Graduate Program in Nutritional Sciences and Department of Biochemistry, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
    Exp Biol Med (Maywood) 226:766-75. 2001
    ..Thus, during development, atRA may play a role in fine-tuning embryonic responsiveness to both NT-3 and NGF...
  100. ncbi Novel functional interactions between Trk kinase and p75 neurotrophin receptor in neuroblastoma cells
    Mahesh B Lachyankar
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Neurosci Res 71:157-72. 2003
    ..An anti-p75 antibody blocked the survival effect of NGF. Brain-derived neurotrophic factor also enhanced cell survival, indicating that in differentiated cells, NGF acts through the p75 receptor to prevent apoptosis...
  101. ncbi FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling
    Wen-Hua Zheng
    Douglas Hospital Research Center, Departments of Psychiatry, and Pharmacology and Therapeutics, McGill University, Montreal, Canada
    J Neurochem 80:1049-61. 2002
    ..NGF rapidly induced the phosphorylation of FKHRL1 in PC12 cells. This effect is mediated by high-affinity TrkA receptor as nerve growth factor (NGF) induced the phosphorylation of FKHRL1 only in TrkA expressing cells and not p75-..

Research Grants75

  1. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..Aim 2: p75NTR and Trk receptors interact to regulate the affinity of TrkA receptor for its cognate ligand, NGF...
  2. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..Aim 2: p75NTR and Trk receptors interact to regulate the affinity of TrkA receptor for its cognate ligand, NGF...
  3. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2009
    ..between afferent neurons in DRG that is initiated, in part, by increases in nerve growth factor (NGF)/TrkA receptor and associated signaling pathways in colonic afferent neurons...
  4. Remark bundle structure and function in neuropathic pain
    John Griffin; Fiscal Year: 2009
    ..changes, new models of selective nociceptor injury, and a new genetically engineered mouse in which a TrkA receptor kinase mutation is "knocked-in" so that the TrkA is blocked in its signaling by a small molecule inhibitor, ..
  5. Remark bundle structure and function in neuropathic pain
    John W Griffin; Fiscal Year: 2010
    ..changes, new models of selective nociceptor injury, and a new genetically engineered mouse in which a TrkA receptor kinase mutation is "knocked-in" so that the TrkA is blocked in its signaling by a small molecule inhibitor, ..
  6. Remark bundle structure and function in neuropathic pain
    John Griffin; Fiscal Year: 2009
    ..changes, new models of selective nociceptor injury, and a new genetically engineered mouse in which a TrkA receptor kinase mutation is "knocked-in" so that the TrkA is blocked in its signaling by a small molecule inhibitor, ..
  7. Specific targeting of a neuronal subset using a novel chimeric vector pseudotype
    CHRISTOPHER TRIMBY; Fiscal Year: 2007
    ..Loop 2 confers the ability of NGF to bind the TrkA receptor, which is a receptor that is primarily expressed on sensory neurons including those projecting from the dorsal ..
  8. Nerve Growth Factor-Mechanisms for Signal Transduction
    William Mobley; Fiscal Year: 2007
    ..that the NGF signal is retrogradely transported through endosomes that contain NGF bound to its activated TrkA receptor in complex with associated signaling proteins...
  9. NGF RECEPTOR REGULATION OF PROSTATE GROWTH
    Daniel Djakiew; Fiscal Year: 2001
    ..of the prostate is mediated by the paracrine/autocrine interaction between NGF and its cognate high affinity TrkA receptor and the low affinity NGF receptor (LNGFR)...
  10. Imaging nerve growth factor signal transduction in live neurons
    Bianxiao Cui; Fiscal Year: 2007
    ..NGF-lacking endosomes with photo-activatable green fluorescence proteins that are fused to the C-terminal of TrkA receptor. 3...
  11. NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATION
    William Mobley; Fiscal Year: 2002
    ..in which one copy of the NGF gene has been disrupted, and mice in which both copies of the gene for the NGF TrkA receptor has been knocked-out. 4) To define NGF actions on degenerating BFCNs in Ts65Dn...
  12. STRUCTURE/FUNCTION OF TRK RECEPTORS FOR NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2001
    ..The hypothesis being tested is that multiple subdomains of the extracellular domain of the TrkA receptor simultaneously interact with numerous distinct regions of NGF...
  13. IDENTIFICATION OF A NOVEL SIGNAL PATHWAY FOR NGF
    Raymond Birge; Fiscal Year: 2003
    ..In the present application, we shall study the molecular mechanisms by which c-Crk couples the TrkA receptor to the cytoskeleton, with the long-term goal to understand how NGF promotes differentiation and survival...
  14. TRK RECEPTORS AND NEUROTROPHINS
    Luis Parada; Fiscal Year: 2005
    ..the third aim, we will exploit the existence of a TrkA enhancer, to perform structure/function analysis of the TrkA receptor in vivo...
  15. Combinatorial Approaches to Activators of the NGF Recep*
    Nicholas Webster; Fiscal Year: 2005
    ..closely related structures would be a valuable resource for the discovery of small molecule activators of the TrkA receptor. In this proposal, we would like to explore this hypothesis by screening this combinatorial library against ..
  16. Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders
    Alvin V Terry; Fiscal Year: 2010
    ..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
  17. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2011
    ..e., attention and cognitive flexibility). ..
  18. Drug Discovery for Cognitive Impairment Associated with Drugs of Abuse
    Alvin V Terry; Fiscal Year: 2010
    ..In addition to cognitive improvement, choline analogs could also prevent the neural toxicity associated with the chronic abuse of several addictive substances. ..
  19. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2010
    ..e., attention and cognitive flexibility). ..
  20. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2007
    ..These studies are significant because they will contribute to a better understanding of the toxicity associated with a class of agents that continues to pose a significant environmental risk to millions of people worldwide. ..
  21. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2009
    ..e., attention and cognitive flexibility). ..
  22. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2009
    ..e., attention and cognitive flexibility). ..
  23. Antipsychotics: Temporal Effects on Cognitive Function
    Alvin Terry; Fiscal Year: 2006
    ....
  24. Mechanism of Mechanoreceptor Inhibition by Aldosterone
    Heather Drummond; Fiscal Year: 2006
    ..The results from this proposal may help define the molecular mechanism of baroreceptor inhibition by aldosterone and provide a better understanding of the mechanism of autonomic dysfunction in hypertension and chronic heart failure. ..