trka receptor

Summary

Summary: A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with congenital insensitivity to pain with anhidrosis, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

Top Publications

  1. ncbi NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway
    C L Howe
    Department of Neurology, Stanford University Medical Center, 1201 Welch Road, MSLS P211, Stanford, CA 94305, USA
    Neuron 32:801-14. 2001
  2. ncbi The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
    S O Meakin
    Neurodegeneration Research Group, The John P Robarts Research Institute, London, Ontario N6A 5K8, Canada
    J Biol Chem 274:9861-70. 1999
  3. pmc Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules
    Takeshi Nakamura
    Department of Molecular Genetics, National Institute for Longevity Sciences, Program of Protecting the Brain, CREST, JST, Oobu, Aichi 474 8522, Japan
    Mol Cell Biol 22:8721-34. 2002
  4. ncbi On Trk for retrograde signaling
    F D Miller
    Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, H3A 2B4, Montreal, Quebec, Canada
    Neuron 32:767-70. 2001
  5. ncbi Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
    C Wiesmann
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 401:184-8. 1999
  6. pmc A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs
    Yunfu Sun
    Department of Medicine, University of California San Diego, La Jolla, California 93093, USA
    Nat Neurosci 11:1283-93. 2008
  7. ncbi Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking
    Smita Saxena
    Division of Neuropathology, Institute of Pathology, University of Bern, CH 3010 Bern, Switzerland
    Mol Cell Neurosci 28:571-87. 2005
  8. pmc Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair
    A Micera
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 98:6162-7. 2001
  9. ncbi Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma
    Y Sakamoto
    Department of Surgery, Saga Medical School, Saga 849 8501, Japan
    Oncol Rep 8:477-84. 2001
  10. ncbi The trk proto-oncogene encodes a receptor for nerve growth factor
    R Klein
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Cell 65:189-97. 1991

Detail Information

Publications201 found, 100 shown here

  1. ncbi NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway
    C L Howe
    Department of Neurology, Stanford University Medical Center, 1201 Welch Road, MSLS P211, Stanford, CA 94305, USA
    Neuron 32:801-14. 2001
    ..Our results point to the existence of a population of signaling endosomes derived from clathrin-coated membranes in NGF-treated cells...
  2. ncbi The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
    S O Meakin
    Neurodegeneration Research Group, The John P Robarts Research Institute, London, Ontario N6A 5K8, Canada
    J Biol Chem 274:9861-70. 1999
    ..Importantly, overexpression of FRS-2 in cells expressing an NGF nonresponsive TrkA receptor mutant reconstitutes the ability of NGF to stop cell cycle progression and to stimulate neuronal ..
  3. pmc Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules
    Takeshi Nakamura
    Department of Molecular Genetics, National Institute for Longevity Sciences, Program of Protecting the Brain, CREST, JST, Oobu, Aichi 474 8522, Japan
    Mol Cell Biol 22:8721-34. 2002
    ..These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases...
  4. ncbi On Trk for retrograde signaling
    F D Miller
    Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, H3A 2B4, Montreal, Quebec, Canada
    Neuron 32:767-70. 2001
    ....
  5. ncbi Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
    C Wiesmann
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 401:184-8. 1999
    ....
  6. pmc A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs
    Yunfu Sun
    Department of Medicine, University of California San Diego, La Jolla, California 93093, USA
    Nat Neurosci 11:1283-93. 2008
    ..Together these results establish a central role for Islet1 in the transition from sensory neurogenesis to subtype specification...
  7. ncbi Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking
    Smita Saxena
    Division of Neuropathology, Institute of Pathology, University of Bern, CH 3010 Bern, Switzerland
    Mol Cell Neurosci 28:571-87. 2005
    ..Disrupting p75NTR recycling diminished TrkA activation in response to low concentrations of NGF, demonstrating a functional role for the recycling of p75NTR...
  8. pmc Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair
    A Micera
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 98:6162-7. 2001
    ..These data show a direct pro-fibrogenic effect of NGF on skin and lung fibroblasts and therefore indicate a role for NGF in tissue repair and fibrosis...
  9. ncbi Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma
    Y Sakamoto
    Department of Surgery, Saga Medical School, Saga 849 8501, Japan
    Oncol Rep 8:477-84. 2001
    ..The present findings revealed a novel mechanism in PDAC progression that is mediated via a NTs-Trk interaction...
  10. ncbi The trk proto-oncogene encodes a receptor for nerve growth factor
    R Klein
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Cell 65:189-97. 1991
    ..These results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor...
  11. pmc Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1
    H Keilhack
    Research Unit, Molecular Cell Biology, D 07747 Jena, Germany
    J Cell Biol 152:325-34. 2001
    ..Overexpression of SHP-1 results in Ros dephosphorylation and effectively downregulates Ros-dependent proliferation and transformation. We propose that SHP-1 is an important downstream regulator of Ros signaling...
  12. ncbi The Chagas' disease parasite Trypanosoma cruzi exploits nerve growth factor receptor TrkA to infect mammalian hosts
    Milena de Melo-Jorge
    Parasitology Research Center, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Cell Host Microbe 1:251-61. 2007
    ..Thus, TrkA, the nerve growth factor receptor commonly associated with neural survival and protection, may also underlie clinical progression of an important human parasitic disease...
  13. ncbi Nerve growth factor activates persistent Rap1 signaling in endosomes
    C Wu
    Departments of Neurology and Neurological Sciences and of Pediatrics and the Program in Neuroscience, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:5406-16. 2001
    ..We propose that endosomes are a site from which NGF induces the prolonged activation of Rap1 and MAPK...
  14. ncbi Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor
    Y Indo
    Department of Pediatrics, Kumamoto University School of Medicine, Kumamoto, Japan
    Hum Mutat 18:462-71. 2001
    ..Defects in NGF signal transduction at the TRKA receptor lead to failure to support survival of sympathetic ganglion neurons and nociceptive sensory neurons derived ..
  15. ncbi Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
    D R Kaplan
    Eukaryotic Signal Transduction Group, NCI Frederick Cancer Research and Development Center, Maryland 21701
    Nature 350:158-60. 1991
    ..Activation of the trk tyrosine kinase receptor provides a possible mechanism for signal transduction by NGF...
  16. ncbi Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells
    Katharina Hansen
    Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
    J Neurochem 103:259-75. 2007
    ..Our findings suggest that TrkA activation in human glioblastomas might be beneficial therapeutically, especially as several of the currently used chemotherapeutics also induce autophagic cell death...
  17. ncbi A synthetic peptide modeled on PDNF, Chagas' disease parasite neurotrophic factor, promotes survival and differentiation of neuronal cells through TrkA receptor
    Marina V Chuenkova
    Parasitology Research Center, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA
    Biochemistry 44:15685-94. 2005
    ....
  18. ncbi Nerve growth factor effect on human primary fibroblastic-keratocytes: possible mechanism during corneal healing
    Alessandra Micera
    CIR Laboratory of Ophthalmology, University Campus Bio Medico and G B Bietti, Foundation, Via Emilio Longoni 83, 00155 Rome, Italy
    Exp Eye Res 83:747-57. 2006
    ..To sum up, the findings of this study indicate that NGF can modulate some functional activities of fibroblastic-keratocytes, thus substantiating the healing effects of NGF on corneal wound-healing...
  19. ncbi Trk receptor tyrosine kinases: a bridge between cancer and neural development
    A Nakagawara
    Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, 260 8717, Chiba, Japan
    Cancer Lett 169:107-14. 2001
    ..In this short review, the dynamic role of the Trk family receptors signaling in neural development, neurogenic tumors and other cancers will be discussed...
  20. ncbi Expression and activation of the nerve growth factor receptor TrkA in serous ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, Norway
    Clin Cancer Res 9:2248-59. 2003
    ..In addition, we wished to study the possible link between expression of NGF, a novel angiogenic factor and its receptor TrkA, and the expression of factors involved in angiogenesis in effusions and solid tumors...
  21. doi CCM2 mediates death signaling by the TrkA receptor tyrosine kinase
    Liraz Harel
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    Neuron 63:585-91. 2009
    The TrkA receptor tyrosine kinase is crucial for differentiation and survival of nerve-growth-factor-dependent neurons. Paradoxically, TrkA also induces cell death in pediatric tumor cells of neural origin, via an unknown mechanism...
  22. ncbi A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor
    Simon S Murray
    Skirball Institute of Bimolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 24:2742-9. 2004
    ..Coexpression of NRH2 with TrkA receptors resulted in the formation of high-affinity binding sites for NGF. These results indicate that a transmembrane protein related to p75NTR is capable of modulating Trk receptor binding properties...
  23. doi Nerve growth factor enhances cough and airway obstruction via TrkA receptor- and TRPV1-dependent mechanisms
    A Z El-Hashim
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Safat 13110, Kuwait
    Thorax 64:791-7. 2009
    ..Nerve growth factor (NGF) is an important mediator of airway hyper-responsiveness and hyperalgesia but its role in cough is unknown...
  24. ncbi Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophils
    O Noga
    Allergy and Asthma Clinic, Charite, Campus Virchow, Humboldt University, Berlin, Germany
    Clin Exp Allergy 32:1348-54. 2002
    ..Recent studies have shown that nerve growth factor (NGF) can act on several immune cells as well as residential cells. But little is known about their role in modulating eosinophil function via activation of high-affinity receptors...
  25. ncbi Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight
    Sonia Covaceuszach
    LaylineGenomics, Roma, Italy
    Proteins 58:717-27. 2005
    ..The structure of the MNAC13 Fab fragment may assist in the rational structure-based design of high affinity humanized forms of MNAC13, appropriate for therapeutic approaches in neuropathy and inflammatory pain states...
  26. pmc Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures
    Giuseppe Conti
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    Neurosci Res 65:201-9. 2009
    ..The neuroprotective action of NGF is mediated by the TrkA receptor. This study determined whether repeated ECS exposure increased TrkA and NGF protein levels...
  27. ncbi Survival of cholinergic forebrain neurons in developing p75NGFR-deficient mice
    C E Van der Zee
    Department of Anatomy and Neurobiology, Tupper Building, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Science 274:1729-32. 1996
    ..Apparently, p75(NGFR) mediates apoptosis of these developing neurons in the absence of TrkA, and modulation of p75(NGFR) can promote neuronal survival. Cholinergic basal forebrain neurons are involved in learning and memory...
  28. ncbi NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75(NTR) receptor
    Robert G Goold
    The MRC Centre for Developmental Neurobiology, King s College London, London, UK
    J Neurochem 87:935-46. 2003
    ..Finally, inhibition of TrkA receptor tyrosine kinase activity in PC12 cells and superior cervical ganglion neurons with K252a potently and dose-..
  29. ncbi An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors
    H Kong
    Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, USA
    J Neurosci 21:176-85. 2001
    ....
  30. ncbi NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals
    Jean Dominique Delcroix
    Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, USA
    Neuron 39:69-84. 2003
    ..Our results are evidence that signaling endosomes, with the characteristics of early endosomes, convey NGF signals from the target of nociceptive neurons to their cell bodies...
  31. ncbi NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination
    Xinhua Lee
    Department of Discovery Biology, Biogen Idec, Cambridge, Massachusetts 02142, USA
    J Neurosci 27:220-5. 2007
    ..The implications of these results relate specifically to the development of potential therapeutics targeting extrinsic growth factors that may regulate the axonal expression of modulators of oligodendrocyte development...
  32. ncbi Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome
    Francisca C Bronfman
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurosci 23:3209-20. 2003
    ..These data suggest that signaling endosomes containing activated p75 are involved in neurotrophin signaling, and that such endosomes may be temporally and spatially distinct from those containing trk receptors...
  33. pmc NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes
    Jonah R Chan
    Department of Neurobiology, Stanford University School of Medicine, Fairchild Science Building D235, CA 94305, USA
    Neuron 43:183-91. 2004
    ..These findings indicate a novel role for growth factors in regulating the receptivity of axons to myelination and reveal that different axonal signals control central and peripheral myelination...
  34. ncbi Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation
    T T Yeo
    Department of Neurology, University of California at San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 17:7594-605. 1997
    ..These findings indicate that p75NTR negatively regulates cholinergic neuronal phenotype of the basal forebrain cholinergic neurons, including cell size, target innervation, and neurotransmitter synthesis...
  35. doi Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cells
    Chunhui Li
    Laboratory of Neural Signalling, The Robarts Research Institute, London, Ontario, Canada
    J Neurochem 112:882-99. 2010
    Ectopic expression of the TrkA receptor tyrosine kinase in tumors of the nervous system can mediate nerve growth factor (NGF)-dependent cell death by apoptosis and /or autophagy...
  36. ncbi Identification and characterization of novel substrates of Trk receptors in developing neurons
    X Qian
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:1017-29. 1998
    ..Together, these observations indicate that rAPS and SH2-B mediate Trk signaling in developing neurons...
  37. ncbi Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
    Michael K Gross
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 34:535-49. 2002
    ..Lbx1, therefore, plays a critical role in the development of sensory pathways in the spinal cord that relay pain and touch...
  38. ncbi Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
    Kwang Mook Jung
    Department of Pathology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Biol Chem 278:42161-9. 2003
    ..our studies suggest that gamma-secretase-mediated p75NTR proteolysis plays a role in the formation/disassembly of the p75-TrkA receptor complex by regulating the availability of the p75 TM domain that is required for this interaction.
  39. ncbi Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes
    Angela Raucci
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Biol Chem 279:1747-56. 2004
    ..These results indicate that inhibition of chondrocyte proliferation by FGF requires both ERK1/2 and p38 MAPK signaling and also suggest that sustained activation of these pathways is required to achieve growth inhibition...
  40. ncbi Origin and evolution of the Trk family of neurotrophic receptors
    Elia Benito-Gutiérrez
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, Barcelona E 08028, Spain
    Mol Cell Neurosci 31:179-92. 2006
    ..It is suggestive to propose that subtle protein mutations, gene duplications, and co-options in particular territories of a primitive Nt/Trk system were instrumental to the development of a complex vertebrate nervous system...
  41. ncbi The p75 neurotrophin receptor: multiple interactors and numerous functions
    Jannifer J Gentry
    Center for Molecular Neuroscience, Department of Biochemistry, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Prog Brain Res 146:25-39. 2004
    ..Here, we review these p75NTR interacting factors and the current evidence as to how they contribute to the functional effects of p75NTR activation...
  42. ncbi Neural crest development and neuroblastoma: the genetic and biological link
    Akira Nakagawara
    Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Prog Brain Res 146:233-42. 2004
    ..Thus, the enigmatic clinical behaviors of neuroblastoma are strictly linked to the molecular mechanism of neural crest development...
  43. ncbi TrkA receptor "hot spots" for binding of NT-3 as a heterologous ligand
    Ljubica Ivanisevic
    Lady Davis Institute Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 282:16754-63. 2007
    ..This study demonstrates that Trk signaling is more complex than previously thought because it involves several receptor subdomains and hot spots...
  44. doi Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function
    Yolanda de Pablo
    Cell Signaling and Apoptosis Group, Department Ciències Médiques Bàsiques, IRBLLEIDA, Lleida, Spain
    J Neurochem 104:124-39. 2008
    ..This is the first evidence that a Tyr residue can simultaneously regulate TrkA receptor trafficking and activity.
  45. pmc Nerve growth factor induces vascular endothelial growth factor expression in granulosa cells via a trkA receptor/mitogen-activated protein kinase-extracellularly regulated kinase 2-dependent pathway
    Marcela Julio-Pieper
    Laboratorio de Endocrinología y Biología de la Reproducción, Hospital Clinico Universidad de Chile, Santos Dumont 999 Independencia, Santiago, Chile
    J Clin Endocrinol Metab 94:3065-71. 2009
    ..Nerve growth factor (NGF) may be one of these factors, because NGF promotes angiogenesis and synthesis of angiogenic factors in other tissues and is produced by human granulosa cells (hGCs)...
  46. doi Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma
    Marco Coassin
    CIR, Laboratory of Ophthalmology, University Campus Bio Medico, Via Alvaro del Portillo, 21, 00128, Rome, Italy
    Graefes Arch Clin Exp Ophthalmol 246:1743-9. 2008
    ..Therefore, this study sought to address whether timely changes in NGF and its receptors, trkA(NGFR) and p75(NTR), might explain the progression of retinal damage during experimental glaucoma...
  47. doi Humoral immunodeficiency in congenital insensitivity to pain with anhidrosis
    Sara Sebnem Kilic
    Department of Pediatric Immunology, Uludag University School of Medicine, Gorukle, Bursa, 16059, Turkey
    Neurogenetics 10:161-5. 2009
    ..The implication of the immune system of the reported patient broadens the clinical phenotype associated with NTRK1 mutations...
  48. ncbi Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes
    F Iannone
    Rheumatology Unit, DIMIMP, Italy
    Rheumatology (Oxford) 41:1413-8. 2002
    ..We aimed to investigate the expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) on chondrocytes from human healthy and osteoarthritic cartilage...
  49. pmc Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation
    Jerome Jullien
    Differentiation and Cell Cycle Group, Laboratoire de Biologie Moleculaire et Cellulaire, UMR 5665 CNRS, Ecole Normale Superieure de Lyon, France
    J Biol Chem 278:8706-16. 2003
    ..This approach and the fidelity of the biochemical properties of the TrkA-GFP demonstrate that real-time visualization of trafficking of tyrosine kinase receptors in the presence or absence of the ligand is feasible...
  50. ncbi Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells
    Yumiko Abe
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago IL, USA
    Spine (Phila Pa 1976) 32:635-42. 2007
    ..In vitro studies of the effects of proinflammatory cytokines on the production of nerve growth factor (NGF) by human intervertebral disc (IVD) cells...
  51. ncbi Nerve growth factor helps protect retina in experimental retinal detachment
    Xiaodong Sun
    Eye Research Institute of Shanghai JiaoTong University, Shanghai, China
    Ophthalmologica 222:58-61. 2008
    ..To investigate the expression of nerve growth factor (NGF) and its receptor TrkA on the retina at different time points after retinal detachment (RD) and the protection effect of NGF in experimental RD...
  52. ncbi Runx1 selectively regulates cell fate specification and axonal projections of dorsal root ganglion neurons
    Masaaki Yoshikawa
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8577, Japan
    Dev Biol 303:663-74. 2007
    ..Our results suggest that Runx1 is involved in the cell fate specification of cutaneous neurons, as well as their projections to central and peripheral targets...
  53. ncbi Decreased first phase insulin response in children with congenital insensitivity to pain with anhidrosis
    Ruth Schreiber
    Pediatric Department, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Pediatr Endocrinol Metab 18:873-7. 2005
    ..Additional studies on the clinical significance of NGF-TrkA effects on insulin secretion are required...
  54. pmc Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment
    M Rihl
    Hannover Medical School MHH, Department of Rheumatology OE 6850, Carl Neuberg Str 1, 30625 Hannover, Germany
    Ann Rheum Dis 64:1542-9. 2005
    ..To investigate whether expression of the four members of the neurotrophin (NT) family and their four corresponding receptors is related to synovial inflammation in patients with spondyloarthritis (SpA).Material and..
  55. ncbi The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA
    Smita Saxena
    Abteilung Neuropathologie, Institut fur Pathologie, Universitat Bern, CH 3010 Bern, Switzerland
    J Neurosci 25:10930-40. 2005
    Nerve growth factor (NGF) and its TrkA receptor exert important bioactivities on neuronal cells such as promoting survival and neurite outgrowth...
  56. ncbi Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa
    Laura Lenzi
    Institute of Neurobiology and Molecular Medicine, Neurobiology Section, CNR, Viale Marx 43 15, 00137 Rome, Italy
    Vision Res 45:1491-500. 2005
    ..This suggests that NGF has an effect on RCS rat retina, probably also through the stimulation of other biological mediators produced and released in the retina...
  57. ncbi Distinct effects of p75 in mediating actions of neurotrophins on basal forebrain oligodendrocytes
    Yangzhou Du
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Mol Cell Neurosci 31:366-75. 2006
    ..On the other hand, K252a, an inhibitor of trk receptors, abolished the effects of the neurotrophins, including BDNF. All neurotrophins activated their respective trk receptors...
  58. ncbi Neurotrophin signalling in health and disease
    Moses V Chao
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Clin Sci (Lond) 110:167-73. 2006
    ..In this review, we consider the signalling pathways activated by neurotrophins in both health and disease states...
  59. ncbi Remodeling of the innervation of pancreatic islets accompanies insulitis preceding onset of diabetes in the NOD mouse
    Solveig Persson-Sjögren
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
    J Neuroimmunol 158:128-37. 2005
    ....
  60. ncbi TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma
    Antonella Tacconelli
    Department of Experimental Medicine, University of L Aquila, Via Vetoio, Coppito 2, 67100 L Aquila, Italy
    Cancer Cell 6:347-60. 2004
    ....
  61. ncbi Oncogenic rearrangements of the NTRK1/NGF receptor
    Marco A Pierotti
    Department of Experimental Oncology and Labs Operative Unit 3, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milan, Italy
    Cancer Lett 232:90-8. 2006
    ..The modalities of their activation, their mechanism of action, the contribution of activating sequences, and the molecular mechanisms underlying their generation will be discussed...
  62. ncbi Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain
    Chih Li Chen
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Neuron 49:365-77. 2006
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy...
  63. ncbi Molecular genetics of hereditary sensory neuropathies
    Michaela Auer-Grumbach
    Department of Internal Medicine, Medical Research Center, Medical University of Graz, Stiftingtalstrasse 24, A 8010 Graz, Austria
    Neuromolecular Med 8:147-58. 2006
    ..Nevertheless, it remains unclear how mutations in the known genes lead to the phenotype of HSN. In this review, we summarize the recent progress of the molecular genetics of the HSN and the implicated genes...
  64. ncbi Neurotrophic activities of trk receptors conserved over 600 million years of evolution
    Gad Beck
    Department of Biological Chemistry, Molecular Neurobiology Group, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurobiol 60:12-20. 2004
    ..Thus, Ltrk is required for neuronal survival, suggesting that trophic activities of the trk receptor family originated before the divergence of molluscan and vertebrate lineages approximately 600 million years ago...
  65. ncbi Neurotrophic factor expression in childhood low-grade astrocytomas and ependymomas
    Antonio Chiaretti
    Paediatric Intensive Care Unit, Catholic University of Sacred Heart, 00168 Rome, Italy
    Childs Nerv Syst 20:412-9. 2004
    ..In accordance with the role of neurotrophic factors in tumour behaviour the aim of the present study was to investigate their expression in two childhood brain neoplasms, namely low-grade astrocytomas and ependymomas...
  66. ncbi Quantum dots monitor TrkA receptor dynamics in the interior of neural PC12 cells
    Sujata Sundara Rajan
    Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006 8921, USA
    Nano Lett 6:2049-59. 2006
    ..QDs are contained in microtubule-associated vesicles and possess transport properties that reflect TrkA receptor dynamics...
  67. ncbi Recent advances in hereditary sensory and autonomic neuropathies
    Kristien Verhoeven
    Peripheral Neuropathy Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Curr Opin Neurol 19:474-80. 2006
    ..This review summarizes the genetic advances of hereditary sensory neuropathies and hereditary sensory and autonomic neuropathies, and provides information on phenotype-genotype correlation and on possible underlying pathomechanisms...
  68. ncbi Expression of NGF, Trka and p75 in human cartilage
    A Gigante
    Clinica Ortopedica, Universita di Ancona, Via Tronto 10, 60020 Torrette di Ancona, Italy
    Eur J Histochem 47:339-44. 2003
    ....
  69. ncbi Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth
    Yasuhiro Indo
    Department of Pediatrics, Kumamoto University School of Medicine, Japan
    Clin Auton Res 12:I20-32. 2002
    ..cause CIPA, the molecular pathology of CIPA provides unique opportunities to explore critical roles of the NGF-TRKA receptor system...
  70. ncbi Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies
    S Shatzky
    Genetics Institute, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel
    Am J Med Genet 92:353-60. 2000
    ..Three polymorphisms in the TrkA protein kinase encoding domain were also observed...
  71. ncbi IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1
    C Miranda
    INSERM Unité 145 and IFR 50, Faculte de Medecine, Nice, France
    J Cell Physiol 186:35-46. 2001
    ..Here, we show that IRS-1 and IRS-2 are phosphorylated on tyrosine in presence of both TRK-T1 and the activated TrkA receptor. These tyrosine phosphorylations lead to IRS-1- and IRS-2-induced recruitment of p85PI3K, SHP-2, and Grb2 and ..
  72. ncbi NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis
    A H Salehi
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada
    Neuron 27:279-88. 2000
    ..Our results show that NRAGE contributes to p75NTR-dependent cell death and suggest novel functions for MAGE family proteins...
  73. ncbi Molecular characterization of the TrkA/NGF receptor minimal enhancer reveals regulation by multiple cis elements to drive embryonic neuron expression
    L Ma
    Center for Developmental Biology, UT Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Development 127:3777-88. 2000
    ..These results provide a foundation for identification of the transcriptional machinery that specifies neurotrophin receptor expression...
  74. ncbi Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation
    Y Zhang
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 20:5671-8. 2000
    ..Thus, interactions between Trk receptor tyrosine kinases and intracellular signaling molecules are dictated both by phosphotyrosine motifs within the receptors and by the intracellular location of phosphorylated receptors...
  75. pmc Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity
    N Y Ip
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591
    Proc Natl Acad Sci U S A 89:3060-4. 1992
    ..However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4...
  76. pmc Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor
    A Chittka
    Cell Biology Program, Weill Graduate School of Cornell University Medical College, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:10705-10. 1999
    ..The translocation of SC-1 to the nucleus was specific for p75, as NGF binding to the TrkA receptor did not lead to nuclear localization of SC-1...
  77. ncbi The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor
    S Pollack
    Department of Biochemistry, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, United Kingdom
    Mol Pharmacol 56:185-95. 1999
    ..Because L-753, 000 selectively potentiates the NT-3-induced stimulation of TrkA without inhibiting Trks and other protein kinases, it represents a novel class of selective modifiers of neurotrophin actions...
  78. pmc POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression
    E J Huang
    Program in Neuroscience, Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0723 USA
    Development 126:2869-82. 1999
    ..In conclusion, our data indicate the specific functions of Brn-3a in controlling the survival and differentiation of trigeminal neurons by regulating expression of each of the three Trk receptors...
  79. pmc The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
    S X Bamji
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Cell Biol 140:911-23. 1998
    ..Together, these data indicate that p75NTR can signal to mediate apoptosis, and that this mechanism is essential for naturally occurring sympathetic neuron death...
  80. ncbi Intraocular production and release of nerve growth factor after iridectomy
    Alessandro Lambiase
    Department of Ophthalmology, University of Rome Tor Vergata, Rome, Italy
    Invest Ophthalmol Vis Sci 43:2334-40. 2002
    ..To determine the presence of nerve growth factor (NGF), NGF mRNA, and NGF receptor (TrkA) in rabbit ocular tissues, and whether changes occur in NGF and NGF mRNA levels after experimental iridectomy...
  81. pmc Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo
    I Farinas
    Department of Physiology, University of California, San Francisco 94143, USA
    Neuron 21:325-34. 1998
    ..Results also indicate that survival of cells expressing both receptors can be maintained by activation of either one alone. NT-3 can thus activate more than one Trk receptor in vivo, which when coexpressed are functionally redundant...
  82. ncbi High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
    B L Hempstead
    Department of Medicine, Cornell University Medical College, New York, New York 10021
    Nature 350:678-83. 1991
    ..These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor...
  83. ncbi Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression
    J H Lin
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 95:393-407. 1998
    ..ETS genes may therefore participate in the development of selective sensory-motor circuits in the spinal cord...
  84. ncbi Rapid physical mapping of the human trk protooncogene (NTRK1) to human chromosome 1q21-q22 by P1 clone selection, fluorescence in situ hybridization (FISH), and computer-assisted microscopy
    H U Weier
    Center for Molecular Cytogenetics, Lawrence Berkeley Laboratory, Berkeley, California 94720, USA
    Genomics 26:390-3. 1995
    ..The scheme presented here can easily be generalized to map physically very small nonrepetitive genomic DNA fragments or incomplete cDNAs...
  85. ncbi Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro
    E Gascon
    Department of Neuroscience, University of Geneva Medical School, 1 rue Michel Servet, CH 1211, Geneva, Switzerland
    Eur J Neurosci 21:69-80. 2005
    ....
  86. ncbi The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC
    B Fayard
    Division of Neuropathology, Institute of Pathology, University of Bern, Bern, Switzerland
    J Neurosci Res 80:18-28. 2005
    ..Taken together, these data indicate that pro-BDNF binds to and activates TrkB and could be involved in TrkB-mediated neurotrophic activity in vivo...
  87. ncbi Multiple acute effects on the membrane potential of PC12 cells produced by nerve growth factor (NGF)
    Kazuhiro Shimazu
    Section on Growth Factors, NICHD, National Institutes of Health NIH, Maryland, USA
    J Cell Physiol 203:501-9. 2005
    ..These results suggest that three different currents are implicated in rapid NGF-induced membrane voltage changes, namely an acutely activated Na+ current, Ca2+-dependent potassium currents and non-selective cation currents...
  88. ncbi p75NTR-mediated signaling promotes the survival of myoblasts and influences muscle strength
    Shailaja Reddypalli
    Department of Biology, University of Texas at San Antonio, 78249, USA
    J Cell Physiol 204:819-29. 2005
    ..Taken together, the data indicate that the p75(NTR) mediates survival of myoblasts prior to differentiation and that the activity of this receptor during myogenesis is important for developing muscle...
  89. ncbi Expression of the neurotrophin receptor TrkB is associated with unfavorable outcome in Wilms' tumor
    A Eggert
    Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Clin Oncol 19:689-96. 2001
    ..Conversely, TrkBtrunc expression is associated with excellent outcome, perhaps as a result of a dominant negative effect...
  90. pmc A model for neuronal competition during development
    Christopher D Deppmann
    Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 320:369-73. 2008
    ..We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects...
  91. ncbi Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation
    M K Jezierski
    Department of Human Anatomy and Medical Neurobiology, The Texas A and M University System Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843-1114, USA
    Neurobiol Aging 22:309-19. 2001
    ..Changes in the proportion or ratio of steroid receptor/coactivator systems in the aging forebrain may contribute to the refractory response to estrogen in the reproductively senescent animals...
  92. ncbi Nestin-expressing neural stem cells identified in the scar following myocardial infarction
    Jessica Drapeau
    Department of Physiology, University of Montreal, Montreal, Quebec, Canada
    J Cell Physiol 204:51-62. 2005
    ..These data highlight the novel observation that neural stem cells were recruited to the infarct region of the damaged rat heart and may contribute in part to nerve fiber growth and subsequent innervation of the scar...
  93. ncbi Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways
    T R Bilderback
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA
    J Neurochem 76:1540-51. 2001
    ..In summary, our data suggest that PI 3-kinase regulates the inhibitory crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways and that this interaction localizes to caveolae-related domains...
  94. ncbi Pacinian corpuscle development involves multiple Trk signaling pathways
    J Sedy
    Institute of Anatomy, Charles University, First Faculty of Medicine, U nemocnice 3, 128 00 Prague, Czech Republic
    Dev Dyn 231:551-63. 2004
    ..In addition, NT3/TrkB and/or NT3/TrkA signaling plays a greater role than NT3/TrkC signaling in afferents to developing Pacinian corpuscles...
  95. ncbi Differences in the surface binding and endocytosis of neurotrophins by p75NTR
    Smita Saxena
    Division of Neuropathology, Institute of Pathology, University of Bern, CH 3010 Bern, Switzerland
    Mol Cell Neurosci 26:292-307. 2004
    ..Our results suggest that p75NTR may have multiple roles in different subcellular locations, functioning both at the cell surface and also within endocytic compartments...
  96. ncbi Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors
    E Woodhall
    Department of Anatomy and Physiology, University of Tasmania, P.O. Box 252-24, Hobart, Tasmania 7001, Australia
    Brain Res Mol Brain Res 88:203-13. 2001
    ..The results of the experiments show that ECs express a number of growth factors and that BDNF in particular could act both in a paracrine and autocrine manner...
  97. ncbi Direct, complex effects of estrogens on basal forebrain cholinergic neurons
    Susan H Bora
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Exp Neurol 194:506-22. 2005
    ..Our findings support the idea that estrogens directly enhance cholinergic neuron function and that ERalpha plays a significant role in transducing these regulatory effects...
  98. ncbi TrkA NGF receptor plays a role in the modulation of p75NTR expression
    Sherri L Rankin
    Division of Basic Medical Sciences M5352, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Phillip Drive, St John s, Nfld, Canada A1B 3V6
    Neurosci Lett 383:305-10. 2005
    ..Together these results indicate a role for the individual tyrosine autophosphorylation sites of TrkA in regulating p75NTR expression...
  99. ncbi Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?
    Grant D Nicol
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Interv 7:26-41. 2007
    ..Furthermore, controversy exists as to the downstream signaling pathways involved in NGF-induced peripheral sensitization...
  100. ncbi Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines
    Harald Stephan
    Department of Pediatric Hematology, Oncology and Endocrinology, University Hospital of Essen, Essen, Germany
    Pediatr Blood Cancer 50:218-22. 2008
    ..Expression of Trk receptors has been implicated in the pathogenesis and prognosis of embryonal tumors, including neuroblastoma, nephroblastoma, and medulloblastoma...
  101. ncbi Study of expression patterns and levels of neurotrophins and neurotrophin receptors in ulcerative colitis
    Malin Johansson
    Department of Integrative Medical Biology, Section of Anatomy, Umea University, Umea, Sweden
    Inflamm Bowel Dis 13:398-409. 2007
    ..Neurotrophins may be involved in ulcerative colitis (UC). Yet, it is unclear whether if their effects should be blocked...

Research Grants75

  1. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..Aim 2: p75NTR and Trk receptors interact to regulate the affinity of TrkA receptor for its cognate ligand, NGF...
  2. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..Aim 2: p75NTR and Trk receptors interact to regulate the affinity of TrkA receptor for its cognate ligand, NGF...
  3. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2009
    ..between afferent neurons in DRG that is initiated, in part, by increases in nerve growth factor (NGF)/TrkA receptor and associated signaling pathways in colonic afferent neurons...
  4. Remark bundle structure and function in neuropathic pain
    John Griffin; Fiscal Year: 2009
    ..changes, new models of selective nociceptor injury, and a new genetically engineered mouse in which a TrkA receptor kinase mutation is "knocked-in" so that the TrkA is blocked in its signaling by a small molecule inhibitor, ..
  5. Remark bundle structure and function in neuropathic pain
    John W Griffin; Fiscal Year: 2010
    ..changes, new models of selective nociceptor injury, and a new genetically engineered mouse in which a TrkA receptor kinase mutation is "knocked-in" so that the TrkA is blocked in its signaling by a small molecule inhibitor, ..
  6. Remark bundle structure and function in neuropathic pain
    John Griffin; Fiscal Year: 2009
    ..changes, new models of selective nociceptor injury, and a new genetically engineered mouse in which a TrkA receptor kinase mutation is "knocked-in" so that the TrkA is blocked in its signaling by a small molecule inhibitor, ..
  7. Specific targeting of a neuronal subset using a novel chimeric vector pseudotype
    CHRISTOPHER TRIMBY; Fiscal Year: 2007
    ..Loop 2 confers the ability of NGF to bind the TrkA receptor, which is a receptor that is primarily expressed on sensory neurons including those projecting from the dorsal ..
  8. Nerve Growth Factor-Mechanisms for Signal Transduction
    William Mobley; Fiscal Year: 2007
    ..that the NGF signal is retrogradely transported through endosomes that contain NGF bound to its activated TrkA receptor in complex with associated signaling proteins...
  9. NGF RECEPTOR REGULATION OF PROSTATE GROWTH
    Daniel Djakiew; Fiscal Year: 2001
    ..of the prostate is mediated by the paracrine/autocrine interaction between NGF and its cognate high affinity TrkA receptor and the low affinity NGF receptor (LNGFR)...
  10. Imaging nerve growth factor signal transduction in live neurons
    Bianxiao Cui; Fiscal Year: 2007
    ..NGF-lacking endosomes with photo-activatable green fluorescence proteins that are fused to the C-terminal of TrkA receptor. 3...
  11. NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATION
    William Mobley; Fiscal Year: 2002
    ..in which one copy of the NGF gene has been disrupted, and mice in which both copies of the gene for the NGF TrkA receptor has been knocked-out. 4) To define NGF actions on degenerating BFCNs in Ts65Dn...
  12. STRUCTURE/FUNCTION OF TRK RECEPTORS FOR NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2001
    ..The hypothesis being tested is that multiple subdomains of the extracellular domain of the TrkA receptor simultaneously interact with numerous distinct regions of NGF...
  13. IDENTIFICATION OF A NOVEL SIGNAL PATHWAY FOR NGF
    Raymond Birge; Fiscal Year: 2003
    ..In the present application, we shall study the molecular mechanisms by which c-Crk couples the TrkA receptor to the cytoskeleton, with the long-term goal to understand how NGF promotes differentiation and survival...
  14. TRK RECEPTORS AND NEUROTROPHINS
    Luis Parada; Fiscal Year: 2005
    ..the third aim, we will exploit the existence of a TrkA enhancer, to perform structure/function analysis of the TrkA receptor in vivo...
  15. Combinatorial Approaches to Activators of the NGF Recep*
    Nicholas Webster; Fiscal Year: 2005
    ..closely related structures would be a valuable resource for the discovery of small molecule activators of the TrkA receptor. In this proposal, we would like to explore this hypothesis by screening this combinatorial library against ..
  16. Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders
    Alvin V Terry; Fiscal Year: 2010
    ..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
  17. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2011
    ..e., attention and cognitive flexibility). ..
  18. Drug Discovery for Cognitive Impairment Associated with Drugs of Abuse
    Alvin V Terry; Fiscal Year: 2010
    ..In addition to cognitive improvement, choline analogs could also prevent the neural toxicity associated with the chronic abuse of several addictive substances. ..
  19. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2010
    ..e., attention and cognitive flexibility). ..
  20. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2007
    ..These studies are significant because they will contribute to a better understanding of the toxicity associated with a class of agents that continues to pose a significant environmental risk to millions of people worldwide. ..
  21. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2009
    ..e., attention and cognitive flexibility). ..
  22. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2009
    ..e., attention and cognitive flexibility). ..
  23. Antipsychotics: Temporal Effects on Cognitive Function
    Alvin Terry; Fiscal Year: 2006
    ....
  24. Mechanism of Mechanoreceptor Inhibition by Aldosterone
    Heather Drummond; Fiscal Year: 2006
    ..The results from this proposal may help define the molecular mechanism of baroreceptor inhibition by aldosterone and provide a better understanding of the mechanism of autonomic dysfunction in hypertension and chronic heart failure. ..