peptide receptors

Summary

Summary: Cell surface receptors that bind peptide messengers with high affinity and regulate intracellular signals which influence the behavior of cells.

Top Publications

  1. ncbi Peptide receptors as molecular targets for cancer diagnosis and therapy
    Jean Claude Reubi
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, CH 3010 Berne, Switzerland
    Endocr Rev 24:389-427. 2003
  2. ncbi Formyl-peptide receptors revisited
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    Trends Immunol 23:541-8. 2002
  3. ncbi Identification of the cellular receptor for anthrax toxin
    K A Bradley
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, 1400 University Avenue, Madison, Wisconsin 53706, USA
    Nature 414:225-9. 2001
  4. ncbi Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting
    Jean Claude Reubi
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Berne, Switzerland
    Eur J Nucl Med Mol Imaging 30:781-93. 2003
  5. ncbi Expression and function of formyl peptide receptors on human fibroblast cells
    Scott E VanCompernolle
    Program in Molecular Cellular and Developmental Biology, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Immunol 171:2050-6. 2003
  6. pmc A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells
    S B Su
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    J Exp Med 189:395-402. 1999
  7. ncbi Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors
    V G Lelianova
    Department of Biochemistry, Imperial College, Exhibition Road, London SW7 2AY, United Kingdom
    J Biol Chem 272:21504-8. 1997
  8. pmc Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor
    J L Gao
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 189:657-62. 1999
  9. ncbi Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy
    Pascale Hoffmann
    Institut National de la Santé et de la Recherche Médicale EMI 01 05, Département réponse et dynamique cellulaires Laboratoire d Angiogenèse, Commissariat a l Energie Atomique Grenoble, France
    Endocrinology 147:1675-84. 2006
  10. ncbi The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors
    Mohammed Akhter Hossain
    Howard Florey Institute and Department of Biochemistry and Molecular Biology, University of Melbourne, Victoria, Australia
    J Biol Chem 283:17287-97. 2008

Detail Information

Publications282 found, 100 shown here

  1. ncbi Peptide receptors as molecular targets for cancer diagnosis and therapy
    Jean Claude Reubi
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, CH 3010 Berne, Switzerland
    Endocr Rev 24:389-427. 2003
    During the past decade, proof of the principle that peptide receptors can be used successfully for in vivo targeting of human cancers has been provided...
  2. ncbi Formyl-peptide receptors revisited
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    Trends Immunol 23:541-8. 2002
    ....
  3. ncbi Identification of the cellular receptor for anthrax toxin
    K A Bradley
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, 1400 University Avenue, Madison, Wisconsin 53706, USA
    Nature 414:225-9. 2001
    ..In addition, a soluble version of this domain can protect cells from the action of the toxin...
  4. ncbi Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting
    Jean Claude Reubi
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Berne, Switzerland
    Eur J Nucl Med Mol Imaging 30:781-93. 2003
    b>Peptide receptors have been found to represent excellent targets for in vivo cancer diagnosis and therapy. Recent in vitro studies have shown that many cancers can overexpress not only one but several peptide receptors concomitantly...
  5. ncbi Expression and function of formyl peptide receptors on human fibroblast cells
    Scott E VanCompernolle
    Program in Molecular Cellular and Developmental Biology, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Immunol 171:2050-6. 2003
    ..This first report of a functional formyl peptide receptor in cells of fibroblast origin opens new possibilities for the role of fibroblasts in innate immune responses...
  6. pmc A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells
    S B Su
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    J Exp Med 189:395-402. 1999
    ..In contrast, SAA was not a ligand or agonist for FPR, the high affinity fMLP receptor. Thus, SAA is the first chemotactic ligand identified for FPRL1. Our results suggest that FPRL1 mediates phagocyte migration in response to SAA...
  7. ncbi Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors
    V G Lelianova
    Department of Biochemistry, Imperial College, Exhibition Road, London SW7 2AY, United Kingdom
    J Biol Chem 272:21504-8. 1997
    ..Our findings suggest that latrophilin may bind unidentified endogenous ligands and transduce signals into nerve terminals, thus implicating G proteins in the control of synaptic vesicle exocytosis...
  8. pmc Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor
    J L Gao
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 189:657-62. 1999
    ..These results indicate that FPR functions in antibacterial host defense in vivo...
  9. ncbi Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy
    Pascale Hoffmann
    Institut National de la Santé et de la Recherche Médicale EMI 01 05, Département réponse et dynamique cellulaires Laboratoire d Angiogenèse, Commissariat a l Energie Atomique Grenoble, France
    Endocrinology 147:1675-84. 2006
    ..The expression pattern of EG-VEGF, its regulation by oxygen tension, and its complementary localization to that of VEGF suggest that this new factor might also be deregulated in preeclampsia...
  10. ncbi The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors
    Mohammed Akhter Hossain
    Howard Florey Institute and Department of Biochemistry and Molecular Biology, University of Melbourne, Victoria, Australia
    J Biol Chem 283:17287-97. 2008
    ..Our results provide new insights into the action of relaxins and demonstrate that the role of the A-chain for relaxin activity is both peptide- and receptor-dependent...
  11. ncbi High expression of peptide receptors as a novel target in gastrointestinal stromal tumours
    Jean Claude Reubi
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Murtenstrasse 31, PO Box 62, 3010 Bern, Switzerland
    Eur J Nucl Med Mol Imaging 31:803-10. 2004
    ..Using in vitro receptor autoradiography to measure peptide receptors, we found that 16/19 GIST expressed bombesin subtype 2 receptors, 16/19 expressed vasoactive intestinal ..
  12. ncbi A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors
    K Ichtchenko
    Departments of Pharmacology, New York University Medical Center, New York, 10016, USA
    J Biol Chem 274:5491-8. 1999
    ....
  13. ncbi Isolation and characterization of putative trefoil peptide receptors
    L Thim
    Department of Protein Chemistry, Health Care Discovery, Novo Nordisk A S, DK 2880, Bagsvaerd, Denmark
    Regul Pept 90:61-8. 2000
    ..This protein thus fulfils some of the criteria for being a TFF receptor or a TFF binding protein...
  14. pmc alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal
    K Ichtchenko
    Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    EMBO J 17:6188-99. 1998
    ..Exocytosis probably requires an additional receptor-independent activity of alpha-latrotoxin that is selectively inhibited by the LtxN4C mutation and by La3+...
  15. ncbi Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin
    Y A Ushkaryov
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235
    Science 257:50-6. 1992
    ..The polymorphic structure of the neurexins, their neural localization, and their sequence similarity to proteins associated with neurogenesis suggest a function as cell recognition molecules in the nerve terminal...
  16. ncbi A soluble receptor decoy protects rats against anthrax lethal toxin challenge
    Heather M Scobie
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
    J Infect Dis 192:1047-51. 2005
    ..Stoichiometric concentrations of sCMG2 protect rats against lethal toxin challenge, making sCMG2 one of the most effective anthrax antitoxins described to date...
  17. pmc Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei
    Haydn M Prosser
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 104:648-53. 2007
    ....
  18. pmc Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptor
    T Powers
    Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco 94143, USA
    EMBO J 16:4880-6. 1997
    ..Our data illustrate the extreme functional conservation between prokaryotic and eukaryotic SRP and SRP receptors and suggest that the basic mechanism of co-translational protein targeting is conserved between bacteria and mammals...
  19. doi Cardiovascular effects of relaxin: from basic science to clinical therapy
    Xiao Jun Du
    Experimental Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Vic 3008, Australia
    Nat Rev Cardiol 7:48-58. 2010
    ....
  20. pmc Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution
    J K Burkhardt
    The University of Chicago, Department of Pathology, Chicago, Illinois 60637, USA
    J Cell Biol 139:469-84. 1997
    ..These results suggest that dynamitin plays a pivotal role in regulating organelle movement at the level of motor-cargo binding...
  21. ncbi Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis
    Chrishan S Samuel
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia
    FASEB J 17:121-3. 2003
    ..Together, these data indicate that relaxin may provide a means to regulate excessive collagen deposition in diseased states characterized by pulmonary fibrosis...
  22. doi Membrane receptors: structure and function of the relaxin family peptide receptors
    Roy C K Kong
    Florey Neuroscience Institutes, University of Melbourne, Victoria 3010, Australia
    Mol Cell Endocrinol 320:1-15. 2010
    ..contrast, relaxin-3 and INSL5 interact with another class of type I GPCRs which lack a large ectodomain, the peptide receptors GPCR135 and GPCR142, respectively...
  23. pmc Demonstration of a multistep mechanism for assembly of the SRP x SRP receptor complex: implications for the catalytic role of SRP RNA
    Xin Zhang
    Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    J Mol Biol 381:581-93. 2008
    ..This provides a coherent model that explains how the 4.5S RNA exerts its catalytic role in SRP x SR complex assembly...
  24. ncbi alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor
    V G Krasnoperov
    Department of Environmental Medicine, New York University Medical Center, New York 10016, USA
    Neuron 18:925-37. 1997
    ..Interaction of CIRL with a specific presynaptic neurotoxin and with a component of the docking-fusion machinery suggests its role in regulation of neurosecretion...
  25. ncbi Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1
    Isabelle I Salles
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cell Microbiol 8:1272-81. 2006
    ..Overall, results from the current study suggest that receptor levels dictate the extent of PA oligomer stability, and shifts in this normal process can lead to cell death via apoptosis in the absence of toxin catalytic subunits...
  26. pmc Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process
    Laurence Abrami
    Department of Genetics and Microbiology, University of Geneva, 1211 Geneva 4, Switzerland
    J Cell Biol 160:321-8. 2003
    ..e., slow endocytosis as a monomer and rapid clathrin-mediated uptake on clustering, make it an ideal anthrax toxin receptor...
  27. ncbi LGR7-truncate is a splice variant of the relaxin receptor LGR7 and is a relaxin antagonist in vitro
    D J Scott
    Howard Florey Institute, University of Melbourne, Victoria 3010, Australia
    Ann N Y Acad Sci 1041:22-6. 2005
    ..Expression of LGR7-Truncate with LGR7 in HEK-293T cells resulted in decreased relaxin-induced signaling of LGR7. LGR7-Truncate is potentially an endogenous regulator of LGR7 signaling...
  28. ncbi Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse
    J L Gao
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 51:270-6. 1998
    ..These results suggest that the FPR gene cluster has undergone differential expansion in mammals with FPRL2, Fpr-rs2, Fpr-rs3, Fpr-rs4, and Fpr-rs5 arising after divergence of human and mouse...
  29. ncbi Quickening the pace of anthrax research: three advances point towards possible therapies
    G Jilani Chaudry
    Trends Microbiol 10:58-62. 2002
    ..Finally, the susceptibility of certain inbred mice to anthrax lethal toxin was associated with mutations in the kinesin-like protein Kif1C, a discovery that could help to explain how anthrax toxin kills animals...
  30. ncbi Synthesis of guanidinium-derived receptor libraries and screening for selective peptide receptors in water
    Kim B Jensen
    Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
    Chemistry 8:1300-9. 2002
    ..2 x 10(4) +/- 2.5 x 10(4) (15 % DMSO/H(2)O, pH 8.75) and with appreciable selectivity over the tripeptide enantiomer 22 and the side chain deprotected tripeptide 20...
  31. ncbi Reactivation of formyl peptide receptors triggers the neutrophil NADPH-oxidase but not a transient rise in intracellular calcium
    Johan Bylund
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    J Biol Chem 278:30578-86. 2003
    ..We show that the deactivated formyl peptide receptors (FPRs) can be reactivated/resensitized by the cytoskeleton-disrupting drug cytochalasin B...
  32. ncbi Relaxin receptor expression in hepatic stellate cells and in cirrhotic rat liver tissue
    Robert G Bennett
    Medical Research Service, Veterans Affairs Medical Center, Omaha, NE 68105, USA
    Ann N Y Acad Sci 1041:185-9. 2005
    ..In conclusion, both LGR7 and LGR8 are expressed in activated HSCs and cirrhotic liver, suggesting that relaxin, InsL3, or relaxin-3 may be useful in the treatment of hepatic fibrosis...
  33. ncbi Genetic targeting of relaxin and insulin-like factor 3 receptors in mice
    Aparna A Kamat
    Department of Obstetrics and Gynecology, 6550 Fannin Street, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 145:4712-20. 2004
    ..Our data indicate that neither Insl3 nor Lgr8 contribute to the RLN signaling pathway. We conclude that the Insl3/Lgr8 and Rln1/Lgr7 actions do not overlap in vivo...
  34. pmc The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane
    J D Miller
    Department of Biochemistry and Biophysics, University of California Medical School, San Francisco 94143 0448
    J Cell Biol 128:273-82. 1995
    ..These findings suggest that a cascade of three directly interacting GTPases functions during protein targeting to the ER membrane...
  35. pmc The signal recognition particle receptor is a complex that contains two distinct polypeptide chains
    S Tajima
    J Cell Biol 103:1167-78. 1986
    ..Mp30 binds to SRP-Sepharose directly and is present in the ER membrane in several-fold molar excess of SR alpha and SR beta. The affinity of mp30 for SRP suggests that it may serve a yet unknown function in protein translocation...
  36. pmc Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo
    Shihui Liu
    Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:12424-9. 2009
    ..Finally, the CMG2-null mice are also shown to be highly resistant to B. anthracis spore infection, attesting to the importance of both anthrax toxin and CMG2 in anthrax infections...
  37. pmc Signal recognition particle (SRP) and SRP receptor: a new paradigm for multistate regulatory GTPases
    Shu ou Shan
    Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Biochemistry 48:6696-704. 2009
    ..We suggest that these multistate regulatory GTPases are uniquely suited to provide spatial and temporal control of complex cellular pathways that require multiple molecular events to occur in a highly coordinated fashion...
  38. ncbi Isolation and biochemical characterization of a Ca2+-independent alpha-latrotoxin-binding protein
    B A Davletov
    Department of Biochemistry, Imperial College, London, SW7 2AY, United Kingdom
    J Biol Chem 271:23239-45. 1996
    ..Our data suggest that latrophilin may represent the Ca2+-independent receptor and/or molecular target for alpha-latrotoxin...
  39. pmc Molecular cloning, characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptor
    B L Tang
    Membrane Biology Laboratory, National University of Singapore
    J Cell Biol 120:325-38. 1993
    ..These tubular structures may serve to mediate transport between the intermediate compartment and the Golgi apparatus...
  40. ncbi A revised model for invariant chain-mediated assembly of MHC class II peptide receptors
    Norbert Koch
    Division of Immunobiology, Institute of Genetics, University of Bonn, Bonn, Germany
    Trends Biochem Sci 32:532-7. 2007
    ..How do inherited allo- or isotypic subunits of MHC class II combine to produce such a variety of functional peptide receptors? We propose a new mechanism in which pairing of matched MHC class II alpha- and beta-subunits is coordinated ..
  41. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
    ..RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors...
  42. ncbi A tetrameric complex of membrane proteins in the endoplasmic reticulum
    E Hartmann
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Eur J Biochem 214:375-81. 1993
    ..The delta subunit spans the membrane only once and has its major portion, containing a disulfide bridge, at the lumenal side. The gamma subunit is predicted to span the membrane four times...
  43. ncbi Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes
    M Durstin
    Department of Physiology, University of Connecticut Health Center, Farmington
    Biochem Biophys Res Commun 201:174-9. 1994
    ..In contrast, FPRL2 RNA is detectable in monocytes but not in neutrophils, and its product could not be activated by N-formylpeptides. Thus, the regulation of FPRL2 gene expression in vivo differs from FPR1 and FPRL1...
  44. ncbi EP 91073 prevents EP 80661-induced penile erection: new evidence for the existence of specific EP peptide receptors mediating penile erection
    M R Melis
    Bernard B. Brodie Department of Neuroscience, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
    Neuropharmacology 41:254-62. 2001
    ..by activating specific receptors in the paraventricular nucleus, located possibly in oxytocinergic neurons mediating penile erection, and show that EP 91073 acts as an antagonist of these EP peptide receptors mediating penile erection.
  45. pmc Multiple conformational switches in a GTPase complex control co-translational protein targeting
    Xin Zhang
    Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 106:1754-9. 2009
    ..Thus, the SRP and SR GTPases, without recruiting external regulatory factors, constitute a self-sufficient system that provides exquisite spatial and temporal control of a complex cellular process...
  46. pmc Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants
    Saulius Sumanas
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 621 C Young Dr South, Los Angeles, CA 90095, USA
    Blood 106:534-41. 2005
    ..Further functional studies of these novel genes should help to elucidate critical early steps leading to the formation of vertebrate blood vessels...
  47. pmc Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport
    F M Townsley
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 12:2821-9. 1993
    ..We suggest that movement of the receptor is controlled by conformational changes and intermolecular interactions within the membrane bilayer...
  48. ncbi The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiae
    K J Blumer
    Department of Biochemistry, University of California, Berkeley 94720
    J Biol Chem 263:10836-42. 1988
    ..These findings demonstrate unequivocally that the STE2 gene product is the membrane component responsible for the ligand recognition function of the yeast alpha-factor receptor...
  49. ncbi Bidirectional transport by distinct populations of COPI-coated vesicles
    L Orci
    Department of Morphology, Faculty of Medicine, University of Geneva Medical Center, Switzerland
    Cell 90:335-49. 1997
    ....
  50. ncbi International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides
    Ross A Bathgate
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Pharmacol Rev 58:7-31. 2006
    ..peptide 3 (LGR8), relaxin-3 (GPCR135), and insulin-like peptide 5 (LGPCR142) be named the relaxin family peptide receptors 1 through 4 (RXFP1-4)...
  51. pmc Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways
    M L Halls
    Department of Pharmacology, Monash University, Clayton, Victoria, Australia
    Br J Pharmacol 150:677-91. 2007
    ..Studies of the distribution and function of RXFP3 suggest that it is a potential target for anti-anxiety and anti-obesity drugs...
  52. ncbi The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy
    Daniela Pasquali
    Department of Clinical and Experimental Medicine and Surgery, Endocrine Unit, Second University of Napoli, Via Pansini 5, 80131 Napoli, Italy
    Endocrinology 147:4245-51. 2006
    ..Thus, the level of EG-VEGF/PK1 could be useful for prostate cancer outcome evaluation and as a target for prostate cancer treatment in the future...
  53. ncbi Desensitization of chemokine receptor CCR5 in dendritic cells at the early stage of differentiation by activation of formyl peptide receptors
    Y Le
    Laboratory of Molecular Immunoregulation, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Clin Immunol 99:365-72. 2001
    Chemokine receptors are subjected to heterologous desensitization by activation of formyl peptide receptors. We investigated the cross-talk between formyl peptide receptors and the chemokine receptor CCR5 in human monocyte-differentiated ..
  54. pmc Anthrax toxin receptor 2-dependent lethal toxin killing in vivo
    Heather M Scobie
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS Pathog 2:e111. 2006
    ..Moreover, a D683K mutant form of PA that bound specifically to human and rat ANTXR2 mediated killing of rats by anthrax lethal toxin, providing strong evidence for the physiological importance of ANTXR2 in anthrax disease pathogenesis...
  55. pmc Paracrine regulation of mammalian oocyte maturation and male germ cell survival
    Kazuhiro Kawamura
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 101:7323-8. 2004
    ....
  56. pmc Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation
    D Borden Lacy
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:13147-51. 2004
    ..We present an example of a receptor negatively regulating pH-dependent membrane insertion...
  57. ncbi Relaxin family peptide receptors--from orphans to therapeutic targets
    Emma T Van der Westhuizen
    Department of Pharmacology, Monash University, Clayton, 3800 Vic, Australia
    Drug Discov Today 13:640-51. 2008
    ..Several of them are the cognate ligands for 4 G-protein-coupled relaxin family peptide receptors (RXFPs; formerly LGR7, LGR8, GPCR135, GPCR142)...
  58. pmc Receptors of anthrax toxin and cell entry
    Gisou van der Goot
    Global Health Institute, Ecole Polytechnique Federale de Lausanne, SV AI Extension, Station 15, 1015 Lausanne, Switzerland
    Mol Aspects Med 30:406-12. 2009
    ..The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed...
  59. doi Molecular imaging targeting peptide receptors
    Margret Schottelius
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, D 81675 Munchen, Germany
    Methods 48:161-77. 2009
    ....
  60. pmc Latrophilin fragments behave as independent proteins that associate and signal on binding of LTX(N4C)
    Kirill E Volynski
    Department of Biological Sciences, Imperial College, London, UK
    EMBO J 23:4423-33. 2004
    ..These findings define a novel principle of structural and functional organisation of the cleaved, two-subunit GPCRs...
  61. ncbi RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle
    Richard J Spanggord
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94705, USA
    Nat Struct Mol Biol 12:1116-22. 2005
    ..The orientation of the RNA suggests how peptide binding and GTP hydrolysis can be coupled through direct structural contact during cycles of SRP-directed protein translocation...
  62. ncbi A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer
    Stephanie Schulz
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 12:4545-52. 2006
    ..However, quantification of GCC expression in tissues by the quantitative reverse transcription-PCR (qRT-PCR) has not undergone analytic and clinicopathologic validation...
  63. ncbi Relaxin receptors in hepatic stellate cells and cirrhotic liver
    Robert G Bennett
    Department of Medical Research, Veterans Affairs Medical Center, 4001 Woolworth Avenue, Omaha, NE 68105, USA
    Biochem Pharmacol 73:1033-40. 2007
    ..Cirrhosis also caused increased expression of both receptors. Therefore, agents that stimulate LGR8 and LGR7 may be therapeutically useful to limit the activation of hepatic stellate cells in liver injury...
  64. pmc Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin
    Andrew R Kompa
    Department of Pharmacology, Monash University, Victoria, 3800, Australia Howard Florey Institute, University of Melbourne, Victoria, 3010, Australia
    Br J Pharmacol 137:710-8. 2002
    ..In non-MI animals, PTX treatment also reduced inotropic responses to relaxin. Differences between responses to (-)-isoprenaline and relaxin can be explained by changes in coupling efficiency occurring at the level of adenylate cyclase...
  65. ncbi Distinct modes of signal recognition particle interaction with the ribosome
    Martin R Pool
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, D 69120 Heidelberg, Germany
    Science 297:1345-8. 2002
    ..When SRP54 contacts SR, SRP54 is rearranged such that it is no longer close to L23a. This repositioning may allow the translocon to dock with the ribosome, leading to insertion of the signal peptide into the translocation channel...
  66. pmc Recognition of a subset of signal sequences by Ssh1p, a Sec61p-related protein in the membrane of endoplasmic reticulum of yeast Saccharomyces cerevisiae
    Sandra Wittke
    Max Delbrück Laboratorium, 50829 Cologne, Germany
    Mol Biol Cell 13:2223-32. 2002
    ....
  67. pmc Predominant membrane localization is an essential feature of the bacterial signal recognition particle receptor
    Miryana Mircheva
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, 79104 Freiburg, Germany
    BMC Biol 7:76. 2009
    ..So far, the exact function of the soluble SR in E. coli is unknown, but it has been suggested that, in contrast to eukaryotes, the prokaryotic SR might bind SRP-RNCs already in the cytosol and only then initiates membrane targeting...
  68. ncbi Activation of orphan receptors by the hormone relaxin
    Sheau Yu Hsu
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 295:671-4. 2002
    ..The wide and divergent distribution of the two relaxin receptors implicates their roles in reproductive, brain, renal, cardiovascular, and other functions...
  69. pmc Relaxin receptors and nitric oxide synthases: search for the missing link
    Silvia Nistri
    Dept Anatomy, Histology and Forensic Medicine, University of Florence, V, le G, Pieraccini, 6 I 50139 Florence, Italy
    Reprod Biol Endocrinol 1:5. 2003
  70. ncbi The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site
    Katharina F Stengel
    Biochemie Zentrum der Universitat Heidelberg, INF 328, D 69120, Heidelberg, Germany
    FEBS Lett 581:5671-6. 2007
    ..In cpFtsY this motif is extended, which might be responsible for the enhanced attachment of the protein to the thylakoid membrane...
  71. doi A cleavable N-terminal membrane anchor is involved in membrane binding of the Escherichia coli SRP receptor
    Benjamin Weiche
    Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Albert Ludwigs Universitat Freiburg, 79104 Freiburg, Germany
    J Mol Biol 377:761-73. 2008
    ..These data suggest that membrane binding and function of FtsY are in part regulated by proteolytic cleavage of the conserved 14-amino-acid motif...
  72. ncbi Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs
    Dik J Kwekkeboom
    Department of Nuclear Medicine, Erasmus Medical Center, University Hospital Rotterdam, Rotterdam, The Netherlands
    J Nucl Med 46:62S-6S. 2005
    ..These data compare favorably with those for the limited number of alternative treatment approaches...
  73. pmc Characterization of relaxin receptor (RXFP1) desensitization and internalization in primary human decidual cells and RXFP1-transfected HEK293 cells
    Andras Kern
    The Pacific Biosciences Research Center, University of Hawaii, Honolulu, Hawaii 96822, USA
    Endocrinology 150:2419-28. 2009
    ..These data suggest that the autocrine/paracrine actions of relaxin in the decidua are under additional controls at the level of expression of its receptor on the surface of its target cells...
  74. ncbi Crystal structure of a complex between anthrax toxin and its host cell receptor
    Eugenio Santelli
    Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 430:905-8. 2004
    ..The structure provides new leads for the discovery of anthrax anti-toxins, and should aid the design of cancer therapeutics...
  75. pmc Signal sequences activate the catalytic switch of SRP RNA
    Niels Bradshaw
    Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
    Science 323:127-30. 2009
    ..Thus, SRP RNA is a molecular switch that renders the SRP-SR GTPase engine responsive to signal peptide recruitment, coupling GTP hydrolysis to productive protein targeting...
  76. pmc SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction
    Saskia B Neher
    Howard Hughes Medical Institute, University of California at San Francisco, 600 16th Street, San Francisco, California 94158, USA
    Nat Struct Mol Biol 15:916-23. 2008
    ..These results demonstrate that the N-terminal helices of SRP and SR are autoinhibitory for complex formation in the absence of SRP RNA, suggesting a mechanism for RNA-mediated coordination of the SRP-SR interaction...
  77. pmc Localization of translocation complex components in Bacillus subtilis: enrichment of the signal recognition particle receptor at early sporulation septa
    Aileen Rubio
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0377, USA
    J Bacteriol 187:5000-2. 2005
    ..These results suggest FtsY delivers secreted proteins to SecYEG at the septum, consistent with initial septal localization of forespore membrane proteins...
  78. pmc Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum
    Elisabet C Mandon
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Cell Biol 162:575-85. 2003
    ..We propose that the ribosome-SR interaction accelerates targeting of the ribosome nascent chain complex to the RER, while the SRP-SR interaction is crucial for maintaining the fidelity of the targeting reaction...
  79. ncbi Expression of feeding-related peptide receptors mRNA in GT1-7 cell line and roles of leptin and orexins in control of GnRH secretion
    Ying Yang
    Rui Jin Hospital Affiliated to Shanghai Second Medical University, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China
    Acta Pharmacol Sin 26:976-81. 2005
    To investigate the expression of feeding-related peptide receptors mRNA in GT1-7 cell line and roles of leptin and orexins in the control of GnRH secretion.
  80. ncbi Relaxin is a key mediator of prostate growth and male reproductive tract development
    Chrishan S Samuel
    Molecular Medicine Research Institute, Sunnyvale, California, USA
    Lab Invest 83:1055-67. 2003
    ..Relaxin may mediate its effects on growth and development by serving as an antiapoptotic factor...
  81. pmc An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation
    Ying Jiang
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 180:1149-61. 2008
    ....
  82. ncbi Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions
    Ana Mingorance
    Development and Regeneration of the CNS, Barcelona Science Park IRBB, University of Barcelona, E 08028 Barcelona, Spain
    Mol Cell Neurosci 26:34-49. 2004
    ..In conclusion, our results show that Nogo and its receptor might play key roles during development of hippocampal connections and that they are implicated in neuronal plasticity in the adult...
  83. ncbi Adrenomedullin, a multifunctional regulatory peptide
    J P Hinson
    Department of Molecular and Cellular Biology, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London, United Kingdom
    Endocr Rev 21:138-67. 2000
    ..Finally, in Section V, we consider some unresolved issues and propose future areas for research...
  84. ncbi Membrane association of FtsY, the E. coli SRP receptor
    E De Leeuw
    Department of Microbiology, Institute of Molecular Biological Sciences, BioCentrum Amsterdam, The Netherlands
    FEBS Lett 416:225-9. 1997
    ..The domains were expressed both in vivo and in vitro to examine their subcellular localization. The results suggest that both domains associate with the membrane but that the nature of the association differs...
  85. ncbi The ERD2 gene determines the specificity of the luminal ER protein retention system
    M J Lewis
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 61:1359-63. 1990
    ..lactis allows equal recognition of DDEL and HDEL. Thus the specificity of the retention system is determined by the ERD2 gene. We conclude that ERD2 encodes the receptor that sorts luminal ER proteins...
  86. pmc Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members
    J Fullekrug
    Cell Biology and Cell Biophysics Program, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Mol Biol Cell 10:1939-55. 1999
    ....
  87. pmc A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit
    S C Ogg
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California School of Medicine, San Francisco, California 94143 0448, USA
    J Cell Biol 142:341-54. 1998
    ..This result suggests that SR functions as a regulatory switch that needs to associate with the ER membrane only transiently through interactions with other components...
  88. ncbi Neurexins are functional alpha-latrotoxin receptors
    S Sugita
    Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas 75235, USA
    Neuron 22:489-96. 1999
    ..Thus, alpha-latrotoxin is unique among neurotoxins, because it utilizes two unrelated receptors, probably to amplify recruitment of alpha-latrotoxin to active sites...
  89. pmc Genetic dissection of endocytic trafficking in Drosophila using a horseradish peroxidase-bride of sevenless chimera: hook is required for normal maturation of multivesicular endosomes
    A Sunio
    Center for Basic Neuroscience, Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    Mol Biol Cell 10:847-59. 1999
    ..Our genetic analysis indicates that Hook is required late in endocytic trafficking to negatively regulate delivery from mature MVBs to multilammelar late endosomes and lysosomes...
  90. ncbi Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum
    M J Lewis
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 68:353-64. 1992
    ..Ligand control of receptor movement may limit retrograde flow and thus minimize fruitless recycling of secretory proteins...
  91. ncbi SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane
    I Wada
    Department of Anatomy, McGill University, Montreal, Quebec, Canada
    J Biol Chem 266:19599-610. 1991
    ..We propose that the function of the complex is to regulate Ca(2+)-dependent retention mechanisms for luminal proteins of the endoplasmic reticulum...
  92. ncbi Sequence of a second human KDEL receptor
    M J Lewis
    MRC Laboratory of Molecular Biology, Cambridge, U K
    J Mol Biol 226:913-6. 1992
    ..Here we report the identification of a related human protein with similar properties. This indicates that there are at least two distinct genes in humans that encode functional KDEL receptors...
  93. pmc An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY
    J Luirink
    Department of Microbiology, BioCentrum Amsterdam, The Netherlands
    EMBO J 13:2289-96. 1994
    ..These observations suggest that FtsY is the functional E. coli homolog of the mammalian SRP receptor...
  94. ncbi GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation
    J D Miller
    Department of Biochemistry and Biophysics, University of California Medical School, San Francisco 94143 0448
    Nature 366:351-4. 1993
    ..We propose that nucleotide-mediated conformational changes in SRP54 regulate the release of signal sequences and the docking of ribosomes at the endoplasmic reticulum...
  95. ncbi Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum
    F Letourneur
    Basel Institute for Immunology, Switzerland
    Cell 79:1199-207. 1994
    ..Together, these results suggest that coatomer plays an essential role in retrograde Golgi-to-ER transport and retrieval of dilysine-tagged proteins back to the ER...
  96. ncbi Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton
    E Särndahl
    Department of Cell Biology, Linkoping University, S 581 85 Linkoping, Sweden
    J Biol Chem 271:15267-71. 1996
    ..not only caused a release of Gi2 alpha-subunits from the cytoskeleton but also an association of formyl peptide receptors with the cytoskeleton...
  97. ncbi Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting
    G Bacher
    Zentrum für Molekalare Biologie der Universität Heidelberg, Germany
    Nature 381:248-51. 1996
    ..The contribution of the ribosome had previously escaped detection because only synthetic signal peptides were used in the analysis...
  98. ncbi The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand
    R L Cagan
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles 90024 1570
    Cell 69:393-9. 1992
    ..The receptor-mediated transfer of a transmembrane ligand represents a novel mechanism for protein transfer between developing cells...
  99. ncbi Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7
    Changlu Liu
    Johnson and Johnson Pharmaceutical Research and Development, L L C, San Diego, CA 92121, USA
    Mol Pharmacol 67:231-40. 2005
    ....
  100. ncbi Amylin receptors: molecular composition and pharmacology
    D L Hay
    School of Biological Sciences, University of Auckland, Symonds Street, Auckland, New Zealand
    Biochem Soc Trans 32:865-7. 2004
    ..The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed...
  101. ncbi Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species
    Jingcai Chen
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 312:83-95. 2005
    ..Boels and Schaller recently reported bradykinin as a ligand for GPCR142 (also known as GPR100). In this report, we demonstrate that bradykinin activates neither GPCR135 nor GPCR142, whereas relaxin-3 does...

Research Grants75

  1. SYNTHESIS & APPLICATIONS OF LABELLED FORMYLATING REAGENTS: AMINO ACIDS & PEPTIDE
    MANOUCHEHR SALJOUGHIAN; Fiscal Year: 1999
    ..6 Ci/mmole, and 95% chemical yield. Extensive 1H/3H NMR analysis showed the desired product with the formyl tritium at _ 8.1 ppm in the tritium spectrum and close to 100% radiochemical purity. ..
  2. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..Our team is composed of investigators in 4 different academic institutions in 3 different states, with enormous expertise in all aspects of this proposal. ..
  3. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin Tuder; Fiscal Year: 2009
    ..Our team is composed of investigators in 4 different academic institutions in 3 different states, with enormous expertise in all aspects of this proposal. ..
  4. DEVELOPMENT OF PET RADIOPHARMACEUTICALS TARGETING GRPR
    BUCK ROGERS; Fiscal Year: 2009
    ..These analogs should be useful for the clinical detection and staging of cancers that express GRPR. ..
  5. DEVELOPMENT OF PET RADIOPHARMACEUTICALS TARGETING GRPR
    Buck E Rogers; Fiscal Year: 2010
    ..These analogs should be useful for the clinical detection and staging of cancers that express GRPR. ..
  6. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2010
    ..Therapies that target this inflammatory pathway could improve the quality of life for patients with inflammatory bowel diseases and decrease the lifetime cost of treatment. ..
  7. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2010
    ..Therapies that target this inflammatory pathway could improve the quality of life for patients with inflammatory bowel diseases and decrease the lifetime cost of treatment. ..
  8. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2009
    ..Therapies that target this inflammatory pathway could improve the quality of life for patients with inflammatory bowel diseases and decrease the lifetime cost of treatment. ..
  9. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2010
    ..Disruption of tsetse reproduction would be an effective way to reduce or eliminate fly populations resulting in the prevention of trypanosome transmission to humans and livestock. ..
  10. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2009
    ..Disruption of tsetse reproduction would be an effective way to reduce or eliminate fly populations resulting in the prevention of trypanosome transmission to humans and livestock. ..
  11. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2010
    ..Disruption of tsetse reproduction would be an effective way to reduce or eliminate fly populations resulting in the prevention of trypanosome transmission to humans and livestock. ..
  12. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ....
  13. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MIETTINEN; Fiscal Year: 2009
    ....
  14. MOLECULAR EPIDEMIOLOGY OF CT DETECTED LUNG CANCER
    Joel Weissfeld; Fiscal Year: 2001
    ..abstract_text> ..
  15. MOLECULAR MECHANISMS OF THE ITCH SENSATION IN THE SPINAL CORD
    ZHOUFENG CHEN; Fiscal Year: 2010
    ..Our proposed studies will lead to a better understanding of the itch pathway and pave the way for better designing the strategy for the treatment of chronic itch. ..
  16. MOLECULAR MECHANISMS OF THE ITCH SENSATION IN THE SPINAL CORD
    ZHOUFENG CHEN; Fiscal Year: 2009
    ..Our proposed studies will lead to a better understanding of the itch pathway and pave the way for better designing the strategy for the treatment of chronic itch. ..
  17. Mechanisms of chemoattractant receptor regulation
    HEINI MIETTINEN; Fiscal Year: 2002
    ..This work should provide novel information regarding the regulation of chemoattractant receptor-mediated cell activation. ..
  18. Mechanisms of chemoattractant receptor regulation
    HEINI MIETTINEN; Fiscal Year: 2004
    ..This work should provide novel information regarding the regulation of chemoattractant receptor-mediated cell activation. ..
  19. Mechanisms of chemoattractant receptor regulation
    HEINI MIETTINEN; Fiscal Year: 2005
    ..This work should provide novel information regarding the regulation of chemoattractant receptor-mediated cell activation. ..
  20. Mechanisms of chemoattractant receptor regulation
    HEINI MIETTINEN; Fiscal Year: 2003
    ..This work should provide novel information regarding the regulation of chemoattractant receptor-mediated cell activation. ..
  21. GLIAL B-AMYLOID PEPTIDE RECEPTORS IN ALZHEIMER'S DISEASE
    Kurt Brunden; Fiscal Year: 1993
    ..to BAP, IL-1, PGE2 synthesis) to investigate possible mechanisms of halting of slowing the progress of Alzheimer's Disease...
  22. ROLE OF ESTROGENS IN DEVELOPMENT OF LUNG CANCER
    CHHANDA GUPTA; Fiscal Year: 2001
    ..abstract_text> ..
  23. OPIOID PEPTIDES--RECEPTORS, BIOSYNTHESIS AND RELEASE
    HANS KOSTERLITZ; Fiscal Year: 1990
    ..The amount of released opioid varies between 18 to 30% of the tissue content...
  24. Development of At-211-Labeled Reagents for Therapy of Metastatic Prostate Cancer
    DANIEL SCOTT WILBUR; Fiscal Year: 2010
    ..The new reagents will target the prostate specific membrane antigens (PSMA) or gastrin-releasing peptide receptors (GRP-R) on human prostate cancer cells...
  25. HUMAN N FORMYL PEPTIDE RECEPTOR--REGULATION AND GENETICS
    David Haviland; Fiscal Year: 2000
    ....
  26. HUMAN N FORMYL PEPTIDE RECEPTOR--REGULATION AND GENETICS
    David Haviland; Fiscal Year: 1999
    ....
  27. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2004
    ..Due to its important relationship to mitogenic and other factors involved in carcinogenesis, these studies will greatly contribute to the general understanding of malignant transformation in gastrointestinal and other tissues. ..
  28. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2003
    ..Due to its important relationship to mitogenic and other factors involved in carcinogenesis, these studies will greatly contribute to the general understanding of malignant transformation in gastrointestinal and other tissues. ..
  29. MOLECULAR ANALYSES OF NEUROENDOCRINE PEPTIDE RECEPTORS
    Sunil Sreedharan; Fiscal Year: 1992
    ....
  30. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2000
    ..Due to its important relationship to mitogenic and other factors involved in carcinogenesis, these studies will greatly contribute to the general understanding of malignant transformation in gastrointestinal and other tissues. ..
  31. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2002
    ..Due to its important relationship to mitogenic and other factors involved in carcinogenesis, these studies will greatly contribute to the general understanding of malignant transformation in gastrointestinal and other tissues. ..
  32. DEVELOPMENT OF PEPTIDERGIC PROJECTIONS FROM ARCUATE NUCLEUS OF HYPOTHALAMUS
    Richard Simerly; Fiscal Year: 2000
    ..At present, three mammalian bombesin-like peptide receptors have been characterized; the GRP receptor (also known as the bombesin BB2 receptor), the NMB receptor (also ..
  33. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2001
    ..Due to its important relationship to mitogenic and other factors involved in carcinogenesis, these studies will greatly contribute to the general understanding of malignant transformation in gastrointestinal and other tissues. ..
  34. SIGNAL TRANSDUCTION OF A G PROTEIN COUPLED RECEPTOR
    Athan Kuliopulos; Fiscal Year: 1999
    ..These studies should provide the basis for understanding how this receptor activates the downstream signaling pathway and will serve as a general model for other G protein/receptor mutant-related human diseases. ..
  35. BENZODIAZEPINES AND THE GABA A RECEPTOR
    JOSEPH NEALE; Fiscal Year: 1999
    ..we will test the hypothesis that GABA-A subunit expression is regulated by metabotropic acidic amino acid/peptide receptors. Based on data obtained during the previous support interval, we propose that activation of metabotropic ..
  36. OPIOID PEPTIDE DRUG DEVELOPMENT AND BLOOD-BRAIN BARRIER
    William Pardridge; Fiscal Year: 1992
    ..The overall goal of these studies is to develop opioid chimeric peptides that are pharmacologically active in brain in vivo and that are capable of effective transport through the BBB following systemic administration...
  37. OPIOID PEPTIDE DRUG DEVELOPMENT AND BLOOD-BRAIN BARRIER
    William Pardridge; Fiscal Year: 1993
    ..The overall goal of these studies is to develop opioid chimeric peptides that are pharmacologically active in brain in vivo and that are capable of effective transport through the BBB following systemic administration...
  38. Functional characterization of ATP1A1 and DEspR variants associated with essentia
    Nelson Ruiz Opazo; Fiscal Year: 2009
    ....
  39. Functional characterization of ATP1A1 and DEspR variants associated with essentia
    Nelson Ruiz Opazo; Fiscal Year: 2010
    ....
  40. RAMP-altered Class B GPCR Hormone Recognition
    Augen A Pioszak; Fiscal Year: 2012
    ..These studies are also important for the general knowledge we will gain about GPCRs, which will be broadly applicable to several areas of human health and disease. ..
  41. GASTRIN RELEASING PEPTIDE RECEPTOR DESENSITIZATION
    RICHARD BENYA; Fiscal Year: 2000
    ..Finally, we will use synthetic peptides that block the activation of specific G proteins to determine the contribution of each to acute GRP-R desensitization in Swiss 3T3 cells. ..
  42. BRAINSTEM CIRCUITS CONTROLLING GASTROINTESTINAL FUNCTION
    RENATO TRAVAGLI; Fiscal Year: 2003
    ..2): activation of the cAMP-PK pathway reveals otherwise undetectable peptide receptors in GABAergic terminals of the DVC...
  43. BRAINSTEM CIRCUITS CONTROLLING GASTROINTESTINAL FUNCTION
    RENATO TRAVAGLI; Fiscal Year: 2006
    ..2): activation of the cAMP-PK pathway reveals otherwise undetectable peptide receptors in GABAergic terminals of the DVC...
  44. GASTRIN RELEASING PEPTIDE RECEPTOR DESENSITIZATION
    RICHARD BENYA; Fiscal Year: 1999
    ..Finally, we will use synthetic peptides that block the activation of specific G proteins to determine the contribution of each to acute GRP-R desensitization in Swiss 3T3 cells. ..
  45. BRAINSTEM CIRCUITS CONTROLLING GASTROINTESTINAL FUNCTION
    RENATO TRAVAGLI; Fiscal Year: 2005
    ..2): activation of the cAMP-PK pathway reveals otherwise undetectable peptide receptors in GABAergic terminals of the DVC...
  46. GASTRIN RELEASING PEPTIDE RECEPTOR DESENSITIZATION
    RICHARD BENYA; Fiscal Year: 2000
    ..Finally, we will use synthetic peptides that block the activation of specific G proteins to determine the contribution of each to acute GRP-R desensitization in Swiss 3T3 cells. ..
  47. BRAINSTEM CIRCUITS CONTROLLING GASTROINTESTINAL FUNCTION
    RENATO TRAVAGLI; Fiscal Year: 2004
    ..2): activation of the cAMP-PK pathway reveals otherwise undetectable peptide receptors in GABAergic terminals of the DVC...
  48. GASTRIN RELEASING PEPTIDE RECEPTOR DESENSITIZATION
    RICHARD BENYA; Fiscal Year: 2001
    ..Finally, we will use synthetic peptides that block the activation of specific G proteins to determine the contribution of each to acute GRP-R desensitization in Swiss 3T3 cells. ..
  49. BRAINSTEM CIRCUITS CONTROLLING GASTROINTESTINAL FUNCTION
    RENATO TRAVAGLI; Fiscal Year: 2003
    ..2): activation of the cAMP-PK pathway reveals otherwise undetectable peptide receptors in GABAergic terminals of the DVC...
  50. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2003
    ..Results will likely contribute to the general understanding of mechanisms of gene expression and signaling in cancer biology. ..
  51. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2004
    ..Results will likely contribute to the general understanding of mechanisms of gene expression and signaling in cancer biology. ..
  52. CNS OPIOID MECHANISMS THAT MODULATE REWARD AND AVERSION
    KENNETH CARR; Fiscal Year: 1992
    ....
  53. Effects of Formyl Peptide Receptor variants on function
    John Mills; Fiscal Year: 2004
    ..In addition, we will evaluate them for altered chemotactic activity toward fMLP and the potent agonist fMMWLL.and determine their affinities for virally derived peptides. ..
  54. MECHANISMS OF IMPAIRED REGENERATION IN CIRRHOTIC LIVER
    STEVEN RAPER; Fiscal Year: 1993
    ..mimic the action of SS-14, and alter intracellular accumulation of cyclic AMP; 4) Signaling mechanisms of GI peptide receptors for hepatic proliferation are linked to G proteins, and alterations of G protein structure and function ..
  55. Effects of Formyl Peptide Receptor variants on function
    John Mills; Fiscal Year: 2005
    ..In addition, we will evaluate them for altered chemotactic activity toward fMLP and the potent agonist fMMWLL.and determine their affinities for virally derived peptides. ..
  56. PROTEIN TRANSLOCATION ACROSS ORGANELLE MEMBRANES
    Arnold Strauss; Fiscal Year: 1991
    ..These studies will begin to delineate the basic mechanisms of mitochondrial biogenesis and characterize the molecular and structural basis for MCAD deficiency, a common cause of sudden infant death and Reye's syndrome...
  57. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2003
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
  58. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2005
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
  59. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2004
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
  60. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2006
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
  61. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2006
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
  62. Gastrin-Releasing Peptide Receptor Desensitization
    RICHARD BENYA; Fiscal Year: 2004
    The objective of this proposal is to determine the degree to which functional gastrin-releasing peptide receptors (GRP-R) are expressed in colon cancer, and to elucidate the mechanism(s) by which these receptors regulate the ..
  63. Gastrin-Releasing Peptide Receptor Desensitization
    RICHARD BENYA; Fiscal Year: 2003
    The objective of this proposal is to determine the degree to which functional gastrin-releasing peptide receptors (GRP-R) are expressed in colon cancer, and to elucidate the mechanism(s) by which these receptors regulate the ..
  64. Gastrin-Releasing Peptide Receptor Desensitization
    RICHARD BENYA; Fiscal Year: 2007
    The objective of this proposal is to determine the degree to which functional gastrin-releasing peptide receptors (GRP-R) are expressed in colon cancer, and to elucidate the mechanism(s) by which these receptors regulate the ..
  65. Gastrin-Releasing Peptide Receptor Desensitization
    RICHARD BENYA; Fiscal Year: 2005
    The objective of this proposal is to determine the degree to which functional gastrin-releasing peptide receptors (GRP-R) are expressed in colon cancer, and to elucidate the mechanism(s) by which these receptors regulate the ..
  66. Gastrin-Releasing Peptide Receptor Desensitization
    RICHARD BENYA; Fiscal Year: 2006
    The objective of this proposal is to determine the degree to which functional gastrin-releasing peptide receptors (GRP-R) are expressed in colon cancer, and to elucidate the mechanism(s) by which these receptors regulate the ..
  67. Exploration and development of antiangiogenic peptides for breast cancer
    Aleksander Popel; Fiscal Year: 2009
    ..We have identified a number of peptide receptors on the endothelial cells in vitro using receptor neutralization by monoclonal antibodies...
  68. Sclerostin and Gsalpha signaling in osteoblasts
    JOY Y WU; Fiscal Year: 2010
    ..This proposal seeks to understand how these two pathways interact at the molecular level, as greater insights into the processes by which bone mass is increased may ultimately result in novel therapies for osteoporosis. ..
  69. Exploration and development of antiangiogenic peptides for breast cancer
    Aleksander S Popel; Fiscal Year: 2010
    ..We have identified a number of peptide receptors on the endothelial cells in vitro using receptor neutralization by monoclonal antibodies...
  70. BIOSYNTHESIS AND SECRETION OF PEPTIDE HORMONES
    HOWARD TAGER; Fiscal Year: 1993
    ....