Genomes and Genes
n methyl d aspartate receptors
Summary: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
Publications371 found, 100 shown here
- A synaptic model of memory: long-term potentiation in the hippocampusT V Bliss
Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
Nature 361:31-9. 1993....
- Developmental and regional expression in the rat brain and functional properties of four NMDA receptorsH Monyer
Laboratory of Molecular Neuroscience, Heidelberg University, Federal Republic of Germany
Neuron 12:529-40. 1994..Thus, the distinct expression profiles and functional properties of NR2 subunits provide a basis for NMDA channel heterogeneity in the brain...
- Structural basis of long-term potentiation in single dendritic spinesMasanori Matsuzaki
Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
Nature 429:761-6. 2004..They further suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long-term memory...
- Glutamate exocytosis from astrocytes controls synaptic strengthPascal Jourdain
Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
Nat Neurosci 10:331-9. 2007..Thus, we provide the first combined functional and ultrastructural evidence for a physiological control of synaptic activity via exocytosis of glutamate from astrocytes...
- NMDA receptor subunits: function and pharmacologyPierre Paoletti
Laboratoire de Neurobiologie, CNRS UMR 8544 Ecole Normale Supérieure 46 rue d Ulm, 75005 Paris, France
Curr Opin Pharmacol 7:39-47. 2007....
- NMDA receptor subunits: diversity, development and diseaseS Cull-Candy
Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
Curr Opin Neurobiol 11:327-35. 2001..Recent studies are beginning to address the functional significance of NMDAR diversity under normal and pathological conditions...
- Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophreniaChang Gyu Hahn
Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Med 12:824-8. 2006..Therefore, these findings suggest that enhanced NRG1 signaling may contribute to NMDA hypofunction in schizophrenia...
- Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophreniaJohn E Lisman
Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Trends Neurosci 31:234-42. 2008..iii) Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia...
- NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivoYitao Liu
Brain Research Centre, Vancouver Coastal Health Research Institute and University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
J Neurosci 27:2846-57. 2007....
- Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experienceKazu Nakazawa
Howard Hughes Medical Institute, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 38:305-15. 2003..These results suggest that CA3 NRs play a crucial role in rapid hippocampal encoding of novel information for fast learning of one-time experience...
- Spine-neck geometry determines NMDA receptor-dependent Ca2+ signaling in dendritesJun Noguchi
Department of Cell Physiology, National Institute for Physiological Sciences and Graduate University of Advanced Studies SOKENDAI, Myodaiji, Okazaki 444 8787, Japan
Neuron 46:609-22. 2005..Spine-neck geometry is thus an important determinant of spine Ca2+ signaling, allowing small spines to be the preferential sites for isolated induction of long-term potentiation...
- Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathwaysG E Hardingham
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nat Neurosci 5:405-14. 2002..Specific blockade of extrasynaptic NMDA receptors may effectively prevent neuron loss following stroke and other neuropathological conditions associated with glutamate toxicity...
- NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKIIAndres Barria
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Neuron 48:289-301. 2005..The switch from NR2B to NR2A content in synaptic NMDA-Rs normally observed in many brain regions may contribute to reduced plasticity by controlling the binding of active CaMKII...
- Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticityKoji Yashiro
Department of Cell and Molecular Physiology, Neuroscience Center, and Neurobiology Curriculum, University of North Carolina, Neuroscience Research Building, Campus Box 7545, 115 Mason Farm Road, Chapel Hill, NC 27599 7545, USA
Neuropharmacology 55:1081-94. 2008..Finally, we use the visual cortex as a model system to illustrate how activity-dependent modifications in the NR2A/NR2B ratio may contribute to the development of cortical functions...
- Mice with reduced NMDA receptor expression display behaviors related to schizophreniaA R Mohn
Department of Medicine, University of North Carolina at Chapel Hill 27599 USA
Cell 98:427-36. 1999..These findings support a model in which reduced NMDA receptor activity results in schizophrenic-like behavior and reveals how pharmacological manipulation of monoaminergic pathways can affect this phenotype...
- Subunit arrangement and function in NMDA receptorsHiroyasu Furukawa
Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, New York 10032, USA
Nature 438:185-92. 2005....
- Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95H C Kornau
Center for Molecular Biology ZMBH, University of Heidelberg, Germany
Science 269:1737-40. 1995..The interaction of these proteins may affect the plasticity of excitatory synapses...
- Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neuronsDaniel Saal
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
Neuron 37:577-82. 2003....
- Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brainC Ikonomidou
Department of Pediatric Neurology, Charite Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
Science 283:70-4. 1999..These findings may have relevance to human neurodevelopmental disorders involving prenatal (drug-abusing mothers) or postnatal (pediatric anesthesia) exposure to drugs that block NMDA receptors...
- Ontogeny of postsynaptic density proteins at glutamatergic synapsesRonald S Petralia
Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
Mol Cell Neurosci 29:436-52. 2005..Development was marked by substantial decreases in NR2B and SAP102 and increases in NR2A, PSD-95, AMPA receptors, and CaMKII. Other components showed more moderate changes...
- A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brainShaoyu Ge
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 54:559-66. 2007....
- Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving miceAgnes Gruart
Division de Neurociencias, Universidad Pablo de Olavide, 41013 Sevilla, Spain
J Neurosci 26:1077-87. 2006..Our results provide evidence of a relationship between activity-dependent synaptic plasticity and associative learning in behaving mice...
- Recent advances in the phencyclidine model of schizophreniaD C Javitt
Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, N Y
Am J Psychiatry 148:1301-8. 1991..The purpose of the present paper is to review recent advances in the study of the molecular mechanisms of PCP action and to describe their implications for the understanding of schizophrenic pathophysiology...
- Requirement for hippocampal CA3 NMDA receptors in associative memory recallKazu Nakazawa
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 297:211-8. 2002..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall...
- Subunit-specific NMDA receptor trafficking to synapsesAndres Barria
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Neuron 35:345-53. 2002..Thus, as with AMPA-Rs, synaptic trafficking of NMDA-Rs is tightly regulated and has subunit-specific rules with functionally important consequences...
- The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memoryJ Z Tsien
Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
Cell 87:1327-38. 1996..Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories...
- Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPsSusumu Tomita
Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
Neuron 45:269-77. 2005..These results establish stargazin as a critical substrate in the bidirectional control of synaptic strength, which is thought to underlie aspects of learning and memory...
- Astrocytic control of synaptic NMDA receptorsC Justin Lee
Center for Neural Science, Division of Life Sciences, Korea Institute of Science and Technology, Seoul, Korea
J Physiol 581:1057-81. 2007..These results suggest that astrocytic G-protein coupled receptors that increase intracellular Ca2+ can tune synaptic NMDA receptor responses...
- Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptorFrank J S Lee
Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, University of Toronto, Toronto, M5T 1R8, Ontario, Canada
Cell 111:219-30. 2002..While one interaction is involved in the inhibition of NMDA receptor-gated currents, the other is implicated in the attenuation of NMDA receptor-mediated excitotoxicity through a PI-3 kinase-dependent pathway...
- NMDA receptor hypofunction model of schizophreniaJ W Olney
Department of Psychiatry, Washington University, School of Medicine, St Louis, MO 63110 1093, USA
J Psychiatr Res 33:523-33. 1999..In this article, we examine this hypothesis in terms of its strengths and weaknesses, its therapeutic implications and ways in which it can be further tested...
- SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spinesThu Jennifer Ngo-Anh
Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
Nat Neurosci 8:642-9. 2005..Thus, blocking SK channels facilitates the induction of long-term potentiation by enhancing NMDAR-dependent Ca(2+) signals within dendritic spines...
- Neuronal activity regulates diffusion across the neck of dendritic spinesBrenda L Bloodgood
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Science 310:866-9. 2005..The regulation of diffusional coupling provides a possible mechanism for determining the amplitude of postsynaptic potentials and the accumulation of plasticity-inducing molecules within the spine head...
- Internalization of ionotropic glutamate receptors in response to mGluR activationE M Snyder
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
Nat Neurosci 4:1079-85. 2001..These data suggest that expression of mGluR-LTD is at least partly postsynaptic, and that a functional consequence of dendritic protein synthesis is the regulation of glutamate receptor trafficking...
- Communication between the synapse and the nucleus in neuronal development, plasticity, and diseaseSonia Cohen
F M Kirby Neurobiology Center, Children s Hospital Boston and Departments of Neurology and Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Cell Dev Biol 24:183-209. 2008....
- Regulation of NMDA receptor trafficking by amyloid-betaEric M Snyder
Laboratory for Molecular and Cellular Neuroscience, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nat Neurosci 8:1051-8. 2005..Dephosphorylation of the NMDA receptor subunit NR2B at Tyr1472 correlated with receptor endocytosis. These data indicate a new mechanism by which amyloid-beta can cause synaptic dysfunction and contribute to Alzheimer disease pathology...
- Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophreniaKenji Hashimoto
Department of Psychiatry, Graduate School of Medicine, Chiba University, Japan
Arch Gen Psychiatry 60:572-6. 2003..The aim of this study was to examine whether serum levels of D- and L-serine in patients with schizophrenia are different from those of healthy controls...
- Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3AS Das
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 393:377-81. 1998..These data suggest that NR3A is involved in the development of synaptic elements by modulating NMDAR activity...
- Genetic enhancement of learning and memory in miceY P Tang
Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
Nature 401:63-9. 1999..Our results suggest that genetic enhancement of mental and cognitive attributes such as intelligence and memory in mammals is feasible...
- The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairmentsRobert W Buchanan
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Am J Psychiatry 164:1593-602. 2007..Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments...
- Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophreniaD Umbricht
Psychiatric University Hospital, Department of Research, PO Box 68, Zurich 8029, Switzerland
Arch Gen Psychiatry 57:1139-47. 2000....
- Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratomaJosep Dalmau
Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Ann Neurol 61:25-36. 2007..To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis...
- Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodiesJosep Dalmau
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Lancet Neurol 7:1091-8. 2008..We aimed to analyse the clinical and immunological features of patients with the disorder and examine the effects of antibodies against NMDA receptors in neuronal cultures...
- Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivoYugo Fukazawa
Mitsubishi Kagaku Institute of Life Sciences MITILS, Machida, 194 8511, Tokyo, Japan
Neuron 38:447-60. 2003..These observations suggest that mechanisms regulating the spine actin cytoskeleton contribute to the persistence of LTP...
- Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampusThomas E Bartlett
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
Neuropharmacology 52:60-70. 2007..4 microM. The lack of effect of 0.1 microM NVP on LTD contrasts with its marked effect on LTP and raises the possibility that different NVP-sensitive NR2 subunit-containing NMDA receptors are required for LTP and LTD in this preparation...
- Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant miceT Kutsuwada
Department of Neuropharmacology, Faculty of Medicine, Niigata University, Japan
Neuron 16:333-44. 1996..In the hippocampus of the mutant mice, synaptic NMDA responses and longterm depression were abolished. These results suggest that the epsilon 2 subunit plays an essential role in both neuronal pattern formation and synaptic plasticity...
- Modulation of triheteromeric NMDA receptors by N-terminal domain ligandsChristopher J Hatton
Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Supérueure, Paris, France
Neuron 46:261-74. 2005..Similarly, NR1/2A/2C receptors are inhibited by zinc with high potency but low efficacy. Therefore, interactions between homologous N-terminal domains determine the unique pharmacological properties of triheteromeric NMDARs...
- The Yin and Yang of NMDA receptor signallingGiles E Hardingham
Department of Preclinical Veterinary Sciences, Royal School of Veterinary Studies, Edinburgh University, Summerhall, UK
Trends Neurosci 26:81-9. 2003....
- Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptorT Nakazawa
Department of Oncology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
J Biol Chem 276:693-9. 2001..These data suggest that Tyr-1472 phosphorylation of GluR epsilon 2 is important for synaptic plasticity...
- Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant miceS G Grant
Center for Neurobiology and Behavior, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032
Science 258:1903-10. 1992..Thus, a common tyrosine kinase pathway may regulate the growth of neurons in the developing hippocampus and the strength of synaptic plasticity in the mature hippocampus...
- An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticityAkira Terashima
Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
Neuron 57:872-82. 2008..In addition, deletion of PICK1 or blockade of PICK1 PDZ binding prevented NMDAR-dependent LTD. Thus, PICK1 plays a critical role in bidirectional NMDAR-dependent long-term synaptic plasticity in the hippocampus...
- SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdalaE S Louise Faber
The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia
Nat Neurosci 8:635-41. 2005..Calcium influx through NMDARs activates SK channels and shunts the resultant excitatory postsynaptic potential. These results demonstrate a new role for SK channels as postsynaptic regulators of synaptic efficacy...
- NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidationE Shimizu
Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
Science 290:1170-4. 2000..Such a synaptic reinforcement process may also serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage...
- Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophreniaJoseph T Coyle
McLean Hospital, Belmont, Massachusetts 02478, USA
Ann N Y Acad Sci 1003:318-27. 2003..Thus, there is convincing evidence that hypofunction of a subset of NMDA receptors may contribute to the symptomatic features of schizophrenia...
- 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor compositionYves P Auberson
Novartis Pharma AG, Klybeckstrasse 141, 4002 Basel, Switzerland
Bioorg Med Chem Lett 12:1099-102. 2002..Their preference for the human NMDAR 1A/2A over 1A/2B subunit composition was optimized, leading to (1RS,1'S)-PEAQX (9r), which shows a >100-fold selectivity...
- NMDA receptor surface mobility depends on NR2A-2B subunitsLaurent Groc
Physiologie Cellulaire de la Synapse, Unité Mixte de Recherche UMR 5091, Centre National de la Recherche Scientifique CNRS, Universite Bordeaux 2, 33077 Bordeaux, France
Proc Natl Acad Sci U S A 103:18769-74. 2006..This suggests that the switch in synaptic NMDAR subtypes depends on the regulation of the receptor surface trafficking...
- LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1D R Grosshans
Department of Pharmacology, University of Colorado Health Science Center, 4200 E Ninth Ave Box C236, Denver, Colorado 80262, USA
Nat Neurosci 5:27-33. 2002..The present study suggests a developmental shift in the LTP-dependent trafficking of AMPA receptors. Moreover, our results indicate that insertion of NMDA receptors may be a key step in regulating synaptic plasticity...
- Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit traffickingPenelope J Hallett
MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurosci 26:4690-700. 2006..Modification of these pathways may be a useful therapeutic target for Parkinson's disease and other basal ganglia disorders in which abnormal function of striatal NMDA receptors contributes to the symptoms of the diseases...
- NMDA receptors are critical for unleashing consolidated auditory fear memoriesCyrinne Ben Mamou
Psychology Department, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec H3A 1B1, Canada
Nat Neurosci 9:1237-9. 2006..These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state...
- Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPsH Markram
Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Jahnstrasse 29, D 69120 Heidelberg, Germany
Science 275:213-5. 1997..These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons...
- Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptorsTommaso Fellin
Istituto CNR di Neuroscienze, Universita di Padova, Viale G Colombo 3, 35121, Italy
Neuron 43:729-43. 2004..Our results reveal a distinct mechanism for neuronal excitation and synchrony and highlight a functional link between astrocytic glutamate and extrasynaptic NMDA receptors...
- Heteromeric NMDA receptors: molecular and functional distinction of subtypesH Monyer
Center for Molecular Biology, University of Heidelberg, Germany
Science 256:1217-21. 1992..Such heteromeric NMDA receptor subtypes may exist in neurons, since NR1 messenger RNA is synthesized throughout the mature rat brain, while NR2 messenger RNA show a differential distribution...
- Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiationCarl Weitlauf
Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
J Neurosci 25:8386-90. 2005..Furthermore, our data demonstrate that care must be exercised in the interpretation of data generated with AAM077 when the compound is applied before an agonist...
- Long-term potentiation--a decade of progress?R C Malenka
Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA
Science 285:1870-4. 1999..This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory...
- Synaptic distribution of the NR1, NR2A and NR2B subunits of the N-methyl-d-aspartate receptor in the rat lumbar spinal cord revealed with an antigen-unmasking techniqueGergely G Nagy
Spinal Cord Group, West Medical Building, Institute of Biomedical and Life Sciences, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
Eur J Neurosci 20:3301-12. 2004..These results suggest that many, but not all, glutamatergic synapses in the spinal cord possess NMDA receptors and that subunit composition varies in different regions...
- The role of CA3 hippocampal NMDA receptors in paired associate learningTarek Rajji
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
J Neurosci 26:908-15. 2006..The findings suggest that CA3 NMDA receptors specifically support the encoding of new experiences to involve incidental and contingent associations...
- D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learningSteven Duffy
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Neuropsychopharmacology 33:1004-18. 2008..By enhancing this form of synaptic plasticity, D-serine could improve cognitive flexibility in psychiatric disorders characterized by perseveration of aberrant ideation or behaviors...
- Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neuronsChristopher G Thomas
Vollum Inst, OHSU L474, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
J Neurophysiol 95:1727-34. 2006..Truncation of the NR2A C terminus did not eliminate synaptic expression of NR2A-containing receptors. Our results indicate that NR2A- and NR2B-containing receptors can be located in either synaptic or extrasynaptic compartments...
- Regulation of NMDA receptors by phosphorylationBo Shiun Chen
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neuropharmacology 53:362-8. 2007..Here we summarize recent advances in the characterization of NMDA receptor phosphorylation, emphasizing subunit-specific phosphorylation, which differentially controls the trafficking and surface expression of NMDA receptors...
- N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's diseaseMannie M Y Fan
Department of Psychiatry Kinsmen Laboratories of Neurological Research, Brain Research Centre, University of British Columbia, Vancouver, BC, Canada
Prog Neurobiol 81:272-93. 2007..Here, we review the literature to date and recent findings concerning the role of NMDARs in HD pathogenesis...
- The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memoryD M Bannerman
Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, England
Psychopharmacology (Berl) 188:552-66. 2006..The aim of this article is to provide a review of studies using N-methyl-D-aspartate (NMDA) receptor antagonists to assess the hippocampal long-term potentiation (LTP)/learning hypothesis...
- Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitterChristine I Nam
Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3200, USA
Proc Natl Acad Sci U S A 102:6137-42. 2005..These results demonstrate that postsynaptic assembly of the glutamatergic synapse may be initiated by presynaptic beta-neurexin and that glutamate release also is required for maturation of synapses...
- Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brainHon Kit Wong
Department of Biology and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
J Comp Neurol 450:303-17. 2002..This information will facilitate future research on NMDARs by providing clues to possible inclusion of the NR3A subunit in NMDARs in many brain regions...
- Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neuronsAnton Ivanov
INMED INSERM Unite 29, 163 Route de Luminy, 13009 Marseille, France
J Physiol 572:789-98. 2006..The negative regulation of the ERK activity might be one of the first signalling events determining brain injury and constitutes a putative target of new pharmacological applications...
- Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulatedGiles E Hardingham
Department of Preclinical Veterinary Sciences, Royal Dick School of Veterinary Studies, Edinburgh University, Summerhall, EH9 1QH, Edinburgh, UK
Biochim Biophys Acta 1600:148-53. 2002....
- Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesisMichael A Sutton
Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
Cell 125:785-99. 2006..These results indicate that NMDAR signaling during miniature synaptic transmission serves to stabilize synaptic function through active suppression of dendritic protein synthesis...
- Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantineFernanda G De Felice
Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
J Biol Chem 282:11590-601. 2007....
- Modular competition driven by NMDA receptor subtypes in spike-timing-dependent plasticityRichard C Gerkin
Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
J Neurophysiol 97:2851-62. 2007..Using a simple model, we show that such a modular competition recapitulates our observations...
- Pathologically activated therapeutics for neuroprotectionStuart A Lipton
Burnham Institute for Medical Research, The Salk Institute for Biological Studies, The Scripps Research Institute, and the University of California at San Diego 10901 North Torrey Pines Road, La Jolla, California 29, 037, USA
Nat Rev Neurosci 8:803-8. 2007..This approach has already met with success, and has led to the development of the potentially neuroprotective drug memantine, an N-methyl-D-aspartate (NMDA)-type and glutamate receptor antagonist...
- Compartmentalized dendritic plasticity and input feature storage in neuronsAttila Losonczy
Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Dr Ashburn, Virginia 20147, USA
Nature 452:436-41. 2008....
- In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal deathM A Martel
Centre for Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
Neuroscience 158:334-43. 2009..In this instance, subunit differences cannot account for the dichotomous nature of NMDA receptor signaling...
- NMDA spikes in basal dendrites of cortical pyramidal neuronsJ Schiller
Department of Physiology and Biophysics, Technion Medical School, Bat Galim, Haifa, Israel
Nature 404:285-9. 2000..In addition, NMDA spikes may serve as a powerful mechanism for modification of the cortical network by inducing long-term strengthening of co-activated neighbouring inputs...
- Novel presynaptic mechanisms for coincidence detection in synaptic plasticityIan Duguid
Wolfson Institute for Biomedical Research and Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
Curr Opin Neurobiol 16:312-22. 2006..Recent studies also indicate the existence of presynaptic coincidence detection that is independent of NMDA receptors, suggesting that such mechanisms have a widespread role in plasticity...
- Sensory processing in schizophrenia: neither simple nor intactDaniel C Javitt
Department of Psychiatry, New York University Langone School of Medicine, Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research NYU School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Schizophr Bull 35:1059-64. 2009..These studies also underscore the severe challenges that individuals with schizophrenia face when trying to decode the complex world around them...
- NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunitAlexander M Binshtok
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
J Neurosci 26:708-15. 2006....
- A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapyMelissa M Norberg
Institute of Living, New Haven, CT 06106, USA
Biol Psychiatry 63:1118-26. 2008..This article provides a quantitative review of DCS-augmented fear extinction and exposure therapy literature...
- Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactionsDaniel C Javitt
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric, Research, New York University School of Medicine, Orangeburg, New York 10962, USA
Int Rev Neurobiol 78:69-108. 2007..Finally, genetic linkage and in vivo neurochemical studies in schizophrenia highlight potential etiological mechanisms giving rise to glutamatergic/NMDA dysfunction in schizophrenia...
- Induction of synaptic long-term potentiation after opioid withdrawalRuth Drdla
Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria
Science 325:207-10. 2009..These findings provide a previously unrecognized target to selectively combat pro-nociceptive effects of opioids without compromising opioid analgesia...
- Long-term potentiation and memoryM A Lynch
Trinity College Institute of Neuroscience, Department of Physiology, Trinity College, Dublin, Ireland
Physiol Rev 84:87-136. 2004....
- Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worseChris G Parsons
Merz Pharmaceuticals, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
Neuropharmacology 53:699-723. 2007....
- LTP maintenance and its protein synthesis-dependenceWickliffe C Abraham
Department of Psychology, University of Otago, Box 56, 95 Union Street, Dunedin 9016, New Zealand
Neurobiol Learn Mem 89:260-8. 2008..However, we highlight areas of research that could be usefully conducted to further our understanding of the properties and protein synthesis-dependence of LTP...
- Ionotropic and metabotropic glutamate receptor structure and pharmacologyJames N C Kew
Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex CM19 5AW, UK
Psychopharmacology (Berl) 179:4-29. 2005..The development of selective ligands, including competitive agonists and antagonists and positive and negative allosteric modulators, has enabled investigation of the functional roles of glutamate receptor family members...
- Spinophilin regulates the formation and function of dendritic spinesJ Feng
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 97:9287-92. 2000..In conclusion, spinophilin appears to be required for the regulation of the properties of dendritic spines...
- Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptorsD J Wyllie
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
J Physiol 510:1-18. 1998..However, the latter were rather variable and some were slower than predicted. Slow decays were associated with patches that had large currents...
- Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor traffickingMyung Jong Kim
The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Neuron 46:745-60. 2005..Preferential coupling of NR2B to SynGAP could explain the subtype-specific function of NR2B-NMDARs in inhibition of Ras-ERK, removal of synaptic AMPARs, and weakening of synaptic transmission...
- Changing subunit composition of heteromeric NMDA receptors during development of rat cortexM Sheng
Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
Nature 368:144-7. 1994..A progressive alteration in subunit composition seen postnatally could contribute to NMDA-receptor variation and changing synaptic plasticity during cortical development...
- IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pain 135:232-9. 2008..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
- Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slicesAlexander Z Harris
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Ave, K426, Bronx, NY 10461, USA
J Physiol 584:509-19. 2007..Our data suggest that any role played by extrasynaptic NMDARs in synaptic transmission is dictated by their subcellular location rather than their subunit composition or mobility...
- Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptorsI Perez-Otano
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 21:1228-37. 2001..Our data demonstrate a role for subunit oligomerization and specifically assembly with the NR1 subunit in the trafficking and plasma membrane targeting of the receptor complex...
- Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosusLarissa Lapteva
Sjögren s Syndrome Clinic, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 54:2505-14. 2006..To assess the association of cognitive dysfunction and depression with serum antibodies to N-methyl-D-aspartate (NMDA) receptor (anti-NR2) and analyze clinical and neuroimaging correlates in patients with systemic lupus erythematosus (SLE)...
- Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2Takashi Nishimura
Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466 8550, Japan
Mol Biol Cell 17:1273-85. 2006..Knockdown of Numb suppressed the ephrin-B1-induced spine development and maturation. These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2...
- A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 ratDaniel A Clayton
Medical Scientist Training Program, Neuroscience Program, and Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 22:3628-37. 2002..These data demonstrate the important role of NR2B in LTP and learning and memory and suggest a role for reduced NR2B expression in age-related cognitive decline...
- Predictors of Pregnancy Outcome in SLE and APSJane E Salmon; Fiscal Year: 2012....
- Presynaptic NMDAR Regulation of Substance P Release in the RVM After InjuryUCHECHUKWU PATRICK MADUKA; Fiscal Year: 2013....
- Central Mechanisms of Orofacial PainJianren Mao; Fiscal Year: 2012..The outcome of this study could lead to the development of new therapeutic tools to treat often intractable and debilitating clinical orofacial pain. ..
- PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSIONPatric K Stanton; Fiscal Year: 2012..The long-term regulation of transmitter release has far-reaching importance to normal synaptic processing dynamics, and controlling pathologic glutamate release during injury or disease. ..
- Dynamics of pH Regulation in the BrainMitchell Chesler; Fiscal Year: 2013....
- HCN Channel Trafficking in EpilepsyDane M Chetkovich; Fiscal Year: 2012....
- Glial-cytokine-neuronal interactions in the mechanisms of persistent painKe Ren; Fiscal Year: 2012..The outcome of these studies will enhance our understanding of functional linkage between the immune and nervous system and help to identify novel targets and agents for management of chronic pain. ..
- Expansion of intracranial hemorrhage by tPA after traumatic brain injuryABD ALROOF HIGAZI; Fiscal Year: 2013..We will test these tPA variants and use mice with genetic deletion of tPA to provide insight into the pathogenesis of progressive ICH post TBI and to develop novel therapeutic interventions. ..
- The Role of Gliotransmission in Cerebral IschemiaShinghua Ding; Fiscal Year: 2013..Results from this project will derive entirely new insights into the causes of ischemia-induced neurodegeneration. ..
- Synaptic targeting and regulation of NMDAR subunitsJOHN ALAN GRAY; Fiscal Year: 2013....
- Permeation, Block, and Gating of NMDA ReceptorsJon W Johnson; Fiscal Year: 2013..The goal is to understand the important differences between the actions of the drugs to provide insight into the drug characteristics that allow one to help Alzheimer's disease patients, and the other to mimic schizophrenia. ..
- Modulation of Hippocampal Synaptic PlasticityCharles F Zorumski; Fiscal Year: 2013..Our long-term goal is to identify ways to preserve and restore synaptic function in individuals with neuropsychiatric illnesses. ..
- GATING KINETICS OF GLYCINERGIC NMDA RECEPTORSKIRSTIE ALYSSA CUMMINGS; Fiscal Year: 2013..Insights from this proposal will spur rational hypotheses to address these gaps in knowledge and will afford a more comprehensive understanding of the underlying molecular mechanism of the pathophysiology of schizophrenia. ..
- Structure and Function of NMDA ReceptorsVasanthi Jayaraman; Fiscal Year: 2013..These functional and structural investigations will provide a comprehensive understanding of the mechanism by which agonists and modulators mediate NMDA receptor function. ..
- MECHANISMS UNDERLYING ADRENAL STEROID MODULATION OF LTPConstantine Pavlides; Fiscal Year: 2000..Understanding the mechanisms underlying their effects on synaptic plasticity will greatly enhance out understanding of how they may be involved in human disease. ..
- Rationally Designing Subunit Selective Antagonists for NR2C/D containing NMDA recTimothy M Acker; Fiscal Year: 2012..These studies will provide first in class subunit-selective pharmacological tools that will aid in furthering our understanding of the physiological and patho-physiological roles played by different NMDA receptors. ..
- mu Opioid Receptor Function in the Enteric Nervous SystemCatia Sternini; Fiscal Year: 2007..abstract_text> ..
- MOLECULAR STUDIES OF BRAIN NMDA RECEPTORSR Suzanne Zukin; Fiscal Year: 2009..Findings from the proposed studies are relevant to our understanding of these devastating and often fatal disorders. ..
- MECHANISMS OF APOPTOTIC DEATH IN DOPAMINERGIC NEURONSAnna Liisa Nieminen; Fiscal Year: 2003..These experiments will yield new information to improve therapy of Parkinson s disease and to prevent the disease s progression. ..
- Steroids-Functional Modulators of Amino Acid ReceptorsDAVID FARB; Fiscal Year: 2007..unreadable] [unreadable]..
- Model Neuron Encoding the Realistic Learning RuleMakoto Nishiyama; Fiscal Year: 2006..These studies will contribute significantly to our understanding the cellular and molecular basis of learning and memory. [unreadable] [unreadable]..
- FOLIC ACID AND HOMOCYSTEINE: MECHANISMS OF HEART DEFECTSThomas Rosenquist; Fiscal Year: 2005..Project 4 will test the elements of each of these hypotheses in a population-based study. ..
- INTRACELLULAR CATIONS AND EXCITOTOXICITYIan Reynolds; Fiscal Year: 2002....
- Activity Dependent Modulation of SK2 ChannelsMike Lin; Fiscal Year: 2009..This proposal is targeted to study the basic mechanisms of synaptic plasticity and memory formation, and will contribute to our fundamental knowledge in plasticity and learning process. ..
- Mechanisms of Ethanol Action on NMDA Receptors and LTPRachel Linger; Fiscal Year: 2004..Biochemical methods will be employed to evaluate the surface expression of NMDARs. We hope that these studies will contribute to the understanding of alcoholism by enhancing our knowledge of how ethanol affects cognition. ..
- N-methyl-D-aspartate Receptors in the Enteric Nervous SystemARSEIMA DEL VALLE PINERO; Fiscal Year: 2008..The identification of the NMDA receptors in the enteric nervous system could lead to the development of drugs that selectively modulate bowel function. [unreadable] [unreadable] [unreadable]..
- Phencyclidine Abuse & Psychosis: Biomedical MechanismsDaniel C Javitt; Fiscal Year: 2010....
- MECHANISMS OF COGNITIVE DYSFUNCTION IN SCHIZOPHRENIADaniel Javitt; Fiscal Year: 2005..This study will evaluate neurophysiological and neurochemical hypotheses concerning potential etiology of early sensory processing dysfunction in schizophrenia. ..
- High-Density ERP mapping & FMRIDaniel Javitt; Fiscal Year: 2002..The equipment will also permit monitoring of background EEG during both human and animal studies. Software is requested for state-of-the-art ERP dipole mapping and ERP/MRI co-registration. ..
- TREATMENT OF NEGATIVE SYMPTOMS AND COGNITIVE IMPAIRMENTSDaniel Javitt; Fiscal Year: 2003..The study will provide new information on the efficacy of d-cycloserine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
- Antipsychotic Actions in Models of NMDA HypofunctionGary Duncan; Fiscal Year: 2007..unreadable] [unreadable]..
- ELEMENTARY SCHOOL NEUROSCIENCE LITERACYGary Duncan; Fiscal Year: 2006..unreadable] [unreadable]..
- NEUROPHYSIOLOGICAL NMDA DYSFUNCTION IN SCHIZOPHRENIADaniel Javitt; Fiscal Year: 2006..The research will build upon studies currently supported by NIH research and career development awards to the candidate, and will permit the candidate to continue to devote >75 percent effort to research. ..
- AIDS-Related Neurotoxicity and Novel NMDAR AntagonistsStuart Lipton; Fiscal Year: 2009..It is anticipated that these preclinical studies investigating the role of the NMDAR in neuronal cell injury may lead to new treatments for the neurological manifestations of AIDS. ..
- Erythropoietin PLUS IGF-IN NEUROPROTECTION FROM AIDSStuart Lipton; Fiscal Year: 2009..Hypothesis Tested: EPO+IGF-I act synergistically to activate the anti-apoptotic PI3 kinase/Akt signaling pathway, and thus provide a synergistic degree of neuroprotection. ..
- RETINAL GANGLION CELLS: ION CHANNELS & TRANSMITTERSStuart A Lipton; Fiscal Year: 2010..To characterize the ligand-binding site of NR3-containing receptors, and use information from  and  to distinguish expression of NR1/NR3 "doublet" receptors from NR1/NR2/NR3 "triplet" receptors on RGCs. ..
- ERYTHROPOIETIN-INDUCED NEUROPROTECTIONStuart Lipton; Fiscal Year: 2005....
- Chemokines and Macrophages in HIV Neuronal ApoptosisStuart Lipton; Fiscal Year: 2003..Neuronal apoptosis due to gp120 or chemokines will be monitored using several approaches. ..
- ETHANOL SENSITIVITY OF NATIVE AND CLONED NMDA RECEPTORSJohn Woodward; Fiscal Year: 2009..Aim 3 will express ethanol-insensitive receptors identified in Aims 1 and 2 in neurons in vitro and in vivo to address which effects of ethanol are mediated by inhibition of NMDA receptors. ..
- Caspase Cleavage of MEF2 Mediates Neuronal ApoptosisStuart Lipton; Fiscal Year: 2007....
- Ethanol sensitivity--native /recombinant NMDA receptorsJohn Woodward; Fiscal Year: 2006..The successful completion of this training plan will substantially enhance the PI's research expertise and his ability to fulfill the goals of his research. ..
- S-Nitrosylation of Matrix Metalloproteinases in AIDSStuart Lipton; Fiscal Year: 2007..In the future, the work proposed here may lead to new therapeutic targets based on the novel extracellular signaling pathway involving NO-related molecules and the MMPs that will be studied. ..
- Neurobiology of Spatial Reversal LearningDeborah Watson; Fiscal Year: 2008..These goals serve the mission of a variety of NIH agencies (e.g., NICHD, NIMH, NIDA, NIHS, and NIAAA). [unreadable] [unreadable] [unreadable]..
- Escalating Cocaine Self-Administration: NMDA MechanismsRichard Allen; Fiscal Year: 2003..abstract_text> ..
- Protein Kinase C Modulation of NMDAR Ethanol SensitivityROSEANNA POPP; Fiscal Year: 2006..Thus, facilitating the future design of novel therapeutic strategies to be used in the treatment of alcoholism and alcohol abuse...
- Calcium Homeostasis and Neonatal Brain InjuryChristopher Turner; Fiscal Year: 2009....
- Novel pharmacotherapies for treatment of ADHDFRANK TARAZI; Fiscal Year: 2003..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
- DEVELOPMENTAL PLASTICITY AND CHRONIC EPILEPSYJohn Swann; Fiscal Year: 2007..Since there are so few animal models of early-onset epilepsy, the studies proposed here offer a unique opportunity to further an understanding of the biological origins of seizure disorders in infancy. ..
- Peripheral and Central Mechanism of Pain in Patients with FibromyalgiaROLAND M STAUD; Fiscal Year: 2010..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
- Cellular and Molecular Mechanisms of Learning in the ZebrafishDavid Glanzman; Fiscal Year: 2007..Such an understanding will facilitate the development of treatments for Alzheimer's disease and other disorders of memory. [unreadable] [unreadable] [unreadable]..
- Alcohol and Developing Neuronal CircuitsCARLOS VALENZUELA; Fiscal Year: 2009..Collectively, these studies will establish that network neuronal activity driven by the excitatory actions of GABAA is a novel and important target of the actions of EtOH during hippocampal development. ..
- Pre and Postsynaptic Consequences of Traumatic CNS InjuryScott M Thompson; Fiscal Year: 2011..Project Narrative: We seek to discover the causes of the form of epilepsy that occurs after a severe head injury and to develop new therapies to treat or prevent this condition. ..
- BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTIONJOSEPH ANTOGNINI; Fiscal Year: 2005..This information will aid the development of newer and safer anesthetics, as well as lead to clinically useful means of modulating the neurotransmitter systems that are themselves modulated by anesthetics. ..
- NALTREXONE BLOCKADE OF NMDAJohn Krystal; Fiscal Year: 2002..Thus, the blockade of the rewarding effects of ketamine by naltrexone may provide insight into an important mechanism underlying the psychopharmacology of ethanol and the treatment of alcoholism. ..
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2010..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
- Marine Toxin Impacts on Neurobehavioral FunctionEdward Levin; Fiscal Year: 2003..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
- NMDA Receptor Dynamics After Brain InjuryAnat Biegon; Fiscal Year: 2011..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
- Signaling cascades and memory deficits during agingThomas C Foster; Fiscal Year: 2010..The long range goal is to provide interventions to delay, prevent, or treat cognitive decline associated with unsuccessful aging in order to improve the health and well- being of older Americans ..
- Cellular and Molecular Basis of Long-Term HabituationDavid Glanzman; Fiscal Year: 2007..Such an understanding will facilitate the development of treatments of diseases of memory, such as Alzheimer's. ..
- Axonal Sprouting of GABAergic Neurons in EpileptogenesisSUZANNE BAUSCH; Fiscal Year: 2004..abstract_text> ..
- AMINO ACID NEUROTRANSMITTER DYSREGULATION IN ALCOHOLISMJohn Krystal; Fiscal Year: 2008..abstract_text> ..
- Norepinephrine Transporters: Targets for ADHDFRANK TARAZI; Fiscal Year: 2004..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..