mitogen receptors

Summary

Summary: Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes.

Top Publications

  1. ncbi DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria
    Oliver Gross
    Medical Faculty, University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 66:102-11. 2004
  2. pmc Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
    David Sancho
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    J Clin Invest 118:2098-110. 2008
  3. pmc Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis
    Nicola Ferri
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Pathol 164:1575-85. 2004
  4. pmc Crystallographic insight into collagen recognition by discoidin domain receptor 2
    Federico Carafoli
    Department of Life Sciences, Imperial College London, London SW7 2AZ, UK
    Structure 17:1573-81. 2009
  5. ncbi The discoidin domain receptor tyrosine kinases are activated by collagen
    W Vogel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell 1:13-23. 1997
  6. ncbi APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif
    E E Bates
    Laboratory for Immunological Research, Schering Plough, Dardilly, France
    J Immunol 163:1973-83. 1999
  7. ncbi Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer
    Jay Sulek
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Histochem Cytochem 55:347-53. 2007
  8. pmc Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production
    Chang Hung Chen
    Department of Immunology, Box 357330, University of Washington, Seattle, WA 98195, USA
    Blood 107:1459-67. 2006
  9. ncbi Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes
    Andrew S J Marshall
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Biol Chem 279:14792-802. 2004
  10. pmc Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications
    Ruth Bargal
    Department of Human Genetics, Hadassah Hebrew University Hospital, POB 12000, Jerusalem, 91120, Israel
    Am J Hum Genet 84:80-4. 2009

Research Grants

Detail Information

Publications161 found, 100 shown here

  1. ncbi DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria
    Oliver Gross
    Medical Faculty, University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
    Kidney Int 66:102-11. 2004
    ..The interaction between type IV collagen and cell surface receptors is believed important for normal renal function as well as significant in chronic renal diseases and we therefore analyzed mice with a targeted deletion of DDR1...
  2. pmc Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
    David Sancho
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    J Clin Invest 118:2098-110. 2008
    ..We conclude that DNGR-1 is a novel, highly specific marker of mouse and human DC subsets that can be exploited for CTL cross-priming and tumor therapy...
  3. pmc Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis
    Nicola Ferri
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Pathol 164:1575-85. 2004
    ..Taken together, these data provide evidence for the potential roles of DDR1 and DDR2 in the regulation of collagen turnover mediated by SMCs in obstructive diseases of blood vessels and the lung...
  4. pmc Crystallographic insight into collagen recognition by discoidin domain receptor 2
    Federico Carafoli
    Department of Life Sciences, Imperial College London, London SW7 2AZ, UK
    Structure 17:1573-81. 2009
    ..A comparison of the GVMGFO-binding sites of DDR2 and SPARC reveals a striking case of convergent evolution in collagen recognition...
  5. ncbi The discoidin domain receptor tyrosine kinases are activated by collagen
    W Vogel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell 1:13-23. 1997
    ..These results suggest that the discoidin-related DDR tyrosine kinases are novel collagen receptors with the potential to control cellular responses to the extracellular matrix...
  6. ncbi APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif
    E E Bates
    Laboratory for Immunological Research, Schering Plough, Dardilly, France
    J Immunol 163:1973-83. 1999
    ..DCIR represents a novel surface molecule expressed by Ag presenting cells, and of potential importance in regulation of DC function...
  7. ncbi Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer
    Jay Sulek
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Histochem Cytochem 55:347-53. 2007
    ..These data suggest that uPARAP/Endo180 participates in the connective tissue destruction during head and neck squamous cell carcinoma progression by mediating cellular uptake and lysosomal degradation of collagen...
  8. pmc Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production
    Chang Hung Chen
    Department of Immunology, Box 357330, University of Washington, Seattle, WA 98195, USA
    Blood 107:1459-67. 2006
    ..Thus, DCAL-2 may program DCs differently depending on whether DCs are signaled via TLRs or by T cells. DCAL-2 may be a potential immunotherapeutic target for modulating autoimmune diseases or for developing vaccines...
  9. ncbi Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes
    Andrew S J Marshall
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Biol Chem 279:14792-802. 2004
    ..These data suggest that MICL is a negative regulator of granulocyte and monocyte function...
  10. pmc Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications
    Ruth Bargal
    Department of Human Genetics, Hadassah Hebrew University Hospital, POB 12000, Jerusalem, 91120, Israel
    Am J Hum Genet 84:80-4. 2009
    ..The results of this study will permit an accurate early prenatal diagnosis and carrier screening for families at risk...
  11. ncbi The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo
    Dirk Wienke
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    Cancer Res 67:10230-40. 2007
    ..Together, these data argue that elevated expression of this receptor in tumor cells could have important consequences in subsets of basal-like carcinomas for which there is a current lack of effective treatment...
  12. ncbi Identification of CLEC12B, an inhibitory receptor on myeloid cells
    Sabrina C Hoffmann
    Institute for Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    J Biol Chem 282:22370-5. 2007
    ....
  13. ncbi Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2
    Rosalyn Ram
    AGY Therapeutics, Inc, 270 East Grand Avenue, South San Francisco, CA 94080, USA
    J Neurooncol 76:239-48. 2006
    ..These results suggest that DDR1a plays a critical role in inducing tumor cell adhesion and invasion, and this invasive phenotype is caused by activation of matrix metalloproteinase-2...
  14. ncbi Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors
    H L Weiner
    Division of Pediatric Neurosurgery, New York University School of Medicine, New York 10016, USA
    Neurosurgery 47:1400-9. 2000
    ..Here, we analyze the cellular origin and distribution of DDR1 expression in human brain tumors and its expression in tumor cells relative to surrounding brain...
  15. ncbi Mammalian collagen receptors
    Birgit Leitinger
    National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK
    Matrix Biol 26:146-55. 2007
    ..In this review, we discuss the structure and function of these receptors, focussing on the principles involved in collagen recognition...
  16. ncbi Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression
    Guangpei Hou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Circ Res 90:1147-9. 2002
    ..These results suggest that active DDR1 kinase is a central mediator of SMC migration...
  17. ncbi An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors
    A Shrivastava
    Begeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Mol Cell 1:25-34. 1997
    ....
  18. pmc The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism
    J P Labrador
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO Rep 2:446-52. 2001
    ..Together our results suggest that DDR2 acts as an extracellular matrix sensor to modulate cell proliferation...
  19. pmc Structural basis of the collagen-binding mode of discoidin domain receptor 2
    Osamu Ichikawa
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    EMBO J 26:4168-76. 2007
    ..The surface profile of the collagen-binding site suggests that the DDR2-DS domain recognizes specific sites on fibrillar collagen. This study provides a molecular basis for the collagen-binding mode of the DDR2-DS domain...
  20. pmc CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes
    Cristal Huysamen
    Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa
    J Biol Chem 283:16693-701. 2008
    ..These data indicate that CLEC9A functions as an activation receptor...
  21. ncbi Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation
    Kyungmi Yang
    Biomedical Research Center, Korea Institute of Science and Technology, 39 1, Hawolgok dong, Sungbuk Ku, Seoul 136 791, Korea
    J Biol Chem 280:39058-66. 2005
    ....
  22. ncbi Discoidin domain receptor 1-deficient mice are resistant to bleomycin-induced lung fibrosis
    Carmel Avivi-Green
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 174:420-7. 2006
    ..Based on previous findings showing increased DDR1 expression in bronchoalveolar lavage cells from patients with idiopathic pulmonary fibrosis, we hypothesized that DDR1 mediates disease progression after lung injury...
  23. ncbi Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors
    J C Boyington
    Structural Biology Section, Office of the Scientific Director, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852, USA
    Immunity 10:75-82. 1999
    ..The formation of this dimer reveals a putative ligand-binding region for HLA-E and suggests how NKG2 interacts with CD94...
  24. ncbi The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2
    Birgit Leitinger
    Department of Medicine, The Sackler Institute for Muscular Skeletal Research, University College London, 5 University Street, London WC1E 6JJ, UK
    J Mol Biol 344:993-1003. 2004
    ..The discovery of a site-specific interaction of DDR2 with collagen II gives novel insight into the nature of the interaction of collagen II with matrix receptors...
  25. ncbi Overexpression of protein tyrosine kinases in human esophageal cancer
    T Nemoto
    Division of Clinical Pathology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Pathobiology 65:195-203. 1997
    ..In addition, we confirmed the expression of two isoforms of DDR/trkE/Cak in normal and cancerous esophagus. Our study suggests that DDR/trkE/Cak plays an important role in the regulation of proliferation of esophageal cancer...
  26. doi Extended and bent conformations of the mannose receptor family
    O Llorca
    Centro de Investigaciones Biologicas, Spanish National Research Council CSIC, Ramiro de Maeztu 9, Campus Universidad Complutense, 28040 Madrid, Spain
    Cell Mol Life Sci 65:1302-10. 2008
    ..Conformational transitions between these two states seem to regulate the interaction of these receptors with ligands and their oligomerization...
  27. ncbi The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis
    L H Engelholm
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Lab Invest 81:1403-14. 2001
    ..The data suggest a function of this novel protease receptor in bone development, possibly mediated through its interactions with uPAR, MMP-13, or collagen V...
  28. pmc The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair
    G Hou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Clin Invest 107:727-35. 2001
    ..Our results support the hypothesis that DDR1 plays an important role as a collagen receptor, mediating intimal thickening after vascular injury...
  29. pmc GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis
    Justin Sturge
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK
    J Cell Biol 162:789-94. 2003
    ..From these studies, we conclude that Endo180 is a crucial link between uPA-uPAR and setting of the internal cellular compass...
  30. pmc Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand
    Elwira Pyz
    The Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, South Africa
    Eur J Immunol 38:1157-63. 2008
    ..Finally, we show that mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis...
  31. pmc A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake
    Lucy East
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    EMBO Rep 4:710-6. 2003
    ....
  32. ncbi Collagen-receptor signaling in health and disease
    W F Vogel
    Laboratory of Extracellular Matrix Signaling and Tumor Invasion, Georg Speyer Haus, Institute for Biomedical Research, affiliated with the Johann Wolfgang Goethe University Frankfurt, 60596 Frankfurt am Main, Germany
    Eur J Dermatol 11:506-14. 2001
    ..Some recently discovered mechanisms of locally controlled expression of collagen, collagen-binding receptors and collagen-degrading proteases in the cellular microenvironment are described...
  33. pmc uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
    Lars H Engelholm
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 160:1009-15. 2003
    ..These studies identify a central function of uPARAP/Endo180 in cellular collagen interactions...
  34. ncbi The mannose receptor family
    Lucy East
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary Jean Mitchell Green Building Chester Beatty Laboratories, 237 Fulham Road, SW3 6JB, London, UK
    Biochim Biophys Acta 1572:364-86. 2002
    ..In addition, they differ in their ability to mediate endocytic and phagocytic events and in their intracellular destinations. Together, they represent a unique group of multidomain, multifunctional receptors...
  35. pmc Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen
    Steven J Wall
    Division of Hematology Oncology and Department of Pediatrics, University of Southern California and the Saban Research Institute of Childrens Hospital, Los Angeles, California 90027, USA
    J Biol Chem 280:40187-94. 2005
    ..Our data provide evidence for a novel direct mechanism by which cell contact with fibrillar collagen restricts proliferation...
  36. ncbi Exploring the collagen-binding site of the DDR1 tyrosine kinase receptor
    Rahim Abdulhussein
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 279:31462-70. 2004
    ....
  37. ncbi Endo180 binds to the C-terminal region of type I collagen
    Emily K Thomas
    Vanderbilt Ingram Cancer Center, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 280:22596-605. 2005
    ..The interaction between Endo180 and the C-terminal region of type I collagen appears to play an important role in cell-matrix adhesion...
  38. ncbi The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family
    Matthew J Howard
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary Jean Mitchell Green Building, Chester Beatty Laboratories, 237 Fulham Rd, London SW3 6JB, United Kingdom
    J Biol Chem 277:32320-31. 2002
    ..These findings demonstrate that despite an overall structural similarity, members of this receptor family employ distinct trafficking mechanisms that may reflect important differences in their physiological functions...
  39. ncbi The discoidin domain receptor DDR2 is a receptor for type X collagen
    Birgit Leitinger
    Division of Biomedical Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Matrix Biol 25:355-64. 2006
    ..Our study is the first to describe a non-fibrillar collagen ligand for DDR2 and will form the basis for further studies into the biological function of collagen X during endochondral ossification...
  40. ncbi Discoidin domain receptor 1 is activated independently of beta(1) integrin
    W Vogel
    Programme in Molecular Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 275:5779-84. 2000
    ..Finally, we show that overexpression of dominant negative DDR1 in the myoblast cell line C2C12 blocks cellular differentiation and the formation of myofibers...
  41. ncbi Expression of Endo180 is spatially and temporally regulated during wound healing
    H A Honardoust
    Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada
    Histopathology 49:634-48. 2006
    ..The aim of this study was to examine the expression of Endo180 during gingival wound regeneration...
  42. pmc Complementary roles of intracellular and pericellular collagen degradation pathways in vivo
    Rebecca A Wagenaar-Miller
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Room 211, Bethesda, MD 20892, USA
    Mol Cell Biol 27:6309-22. 2007
    ..These findings have important implications for the use of pharmacological inhibitors of collagenase activity to prevent connective tissue destruction in a variety of diseases...
  43. ncbi Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor
    H Sheikh
    Department of Biology, Sir Alexander Fleming Building, Imperial College of Science, Technology and Medicine, Imperial College Road, London SW7 2AZ, UK
    J Cell Sci 113:1021-32. 2000
    ....
  44. pmc Identification of disulfide-linked dimers of the receptor tyrosine kinase DDR1
    Rahim Abdulhussein
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 283:12026-33. 2008
    ..The identification of DDR1 dimers provides new insights into the molecular structure of receptor tyrosine kinases and suggests distinct signaling mechanisms of each receptor subfamily...
  45. pmc A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse
    Kiyoshi Kano
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113 8657, Japan
    Mol Endocrinol 22:1866-80. 2008
    ..Taken together, our results indicate that the absence of DDR2 leads to growth retardation and gonadal dysfunction due to peripheral defects in hormonal-responsive pathways in slie mice...
  46. doi Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions
    Richard W Farndale
    Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, UK
    Biochem Soc Trans 36:241-50. 2008
    ..Thus the availability of extracellular collagen-binding proteins may be important in regulating and facilitating direct collagen-receptor interaction...
  47. ncbi Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. Identification of collagen binding sites in DDR2
    Birgit Leitinger
    Sackler Institute for Muscular Skeletal Research, Department of Medicine, University College London, 5 University St, London WC1E 6JJ, United Kingdom
    J Biol Chem 278:16761-9. 2003
    ..In addition, the same loops were required for collagen-dependent receptor activation. It is concluded that the loop region opposite to the polypeptide chain termini of the DDR2 discoidin domain constitutes the collagen recognition site...
  48. ncbi The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling
    Niels Behrendt
    Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, Bldg 7 2, DK 2100 Copenhagen O, Denmark
    Biol Chem 385:103-36. 2004
    ..Both receptors have additional functions that are currently being unraveled. The present discussion of uPAR and uPARAP is centered on their protein structure and molecular and cellular function...
  49. ncbi Localization of discoidin domain receptors in rat kidney
    Rutha Lee
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, Minn, USA
    Nephron Exp Nephrol 97:e62-70. 2004
    ..They are candidate effectors in tissue injury and fibrosis. We investigated the DDR expression in normal and remnant rat kidneys...
  50. pmc Uptake of denatured collagen into hepatic stellate cells: evidence for the involvement of urokinase plasminogen activator receptor-associated protein/Endo180
    Seyed Ali Mousavi
    Department of Molecular Biosciences, University of Oslo, Blindernveien 31, 0316 Oslo, Norway
    Biochem J 387:39-46. 2005
    ..These results together suggest that uPARAP/Endo180 mediates endocytosis of collagen in rat liver stellate cells...
  51. ncbi Elevated expression of tyrosine kinase DDR2 in primary biliary cirrhosis
    Tin K Mao
    Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis, TB 192, Davis, CA 95616, USA
    Autoimmunity 35:521-9. 2002
    ..Primary biliary cirrhosis (PBC) is characterized by chronic progressive destruction of small intrahepatic bile ducts with portal inflammation and cholestasis, leading to fibrosis...
  52. pmc Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor
    Dirk Wienke
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    Mol Biol Cell 14:3592-604. 2003
    ....
  53. ncbi Mannose receptor regulation of macrophage cell migration
    Justin Sturge
    Breakthrough Breast Cancer Research Centre, 237 Fulham Road, London, SW3 6JB UK
    J Leukoc Biol 82:585-93. 2007
    ..As MR is down-regulated during macrophage activation, these findings have implications for the regulation of macrophage migration during different stages of pathogenesis...
  54. ncbi Distribution of Endo180 receptor and ligand in developing articular cartilage
    M J Howard
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Osteoarthritis Cartilage 12:74-82. 2004
    ....
  55. ncbi Sensing extracellular matrix: an update on discoidin domain receptor function
    Wolfgang F Vogel
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario Canada, M5S 1A8
    Cell Signal 18:1108-16. 2006
    ..By highlighting current questions about these unusual collagen receptors, we hope to attract new research on DDRs from a variety of different fields...
  56. doi Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen
    Antonios D Konitsiotis
    Division of National Heart and Lung Institute, Imperial College London, London SW7 2AZ
    J Biol Chem 283:6861-8. 2008
    ..Thus, DDR2 activation may be effected by single triple-helices rather than fibrillar collagen...
  57. pmc Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development
    W F Vogel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5
    Mol Cell Biol 21:2906-17. 2001
    ..These results suggest that DDR1 is a key mediator of the stromal-epithelial interaction during ductal morphogenesis in the mammary gland...
  58. ncbi Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation
    Andrew S J Marshall
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 36:2159-69. 2006
    ..This suggests that human MICL may be involved in the control of myeloid cell activation during inflammation...
  59. ncbi KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity
    Yanmei Han
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Rd, Shanghai 200433, China
    Blood 104:2858-66. 2004
    ..Taken together, our results demonstrate that KLRL1 belongs to the KLR family and is a novel inhibitory NK cell receptor...
  60. pmc Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180
    Angel Rivera-Calzada
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, Campus Universidad Complutense, 28040 Madrid, Spain
    EMBO Rep 4:807-12. 2003
    ..We show that for Endo180, the cysteine-rich domain contacts the second C-type lectin-like domain, thus providing structural insight into how modulation of its several ligand interactions may regulate Endo180 receptor function...
  61. ncbi Lectin binding sites in the vitelline envelope of Bufo arenarum oocytes: role in fertilization
    E J del Pino
    , , , Argentina
    Gamete Res 17:333-42. 1987
    ....
  62. pmc Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly
    Justin Sturge
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, England, UK
    J Cell Biol 175:337-47. 2006
    ..We propose migration driven by Endo180 as a model for the spatial regulation of contractility and adhesion dynamics by endosomes...
  63. pmc Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor
    Louise Bailey
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem J 363:67-72. 2002
    ..We conclude that Endo180 is unlikely to be a receptor for collagenase 3 in relation to either its activation or cell binding and internalization, and that other interaction partners must be sought...
  64. ncbi Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen
    Kazuo Ikeda
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:19206-12. 2002
    ..The data support a model in which Src and the DDR2 receptor cooperate in a regulated fashion to direct the phosphorylation of both the receptor and its targets...
  65. ncbi Characterization of sugar binding by the mannose receptor family member, Endo180
    Lucy East
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    J Biol Chem 277:50469-75. 2002
    ..Thus, although Endo180 and the mannose receptor are now both known to be mannose binding lectins, each receptor is likely to have a distinct set of glycoprotein ligands in vivo...
  66. ncbi Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells
    Wei Zhang
    Department of Microbiology, The Fourth Military Medical University, Xi an, Shaanxi 710032, P R China
    Mol Cell Biochem 290:43-53. 2006
    ..All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II...
  67. doi Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice
    Christopher Franco
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Circ Res 102:1202-11. 2008
    ..In conclusion, our data support a role for DDR1 in the regulation of both inflammation and fibrosis early in plaque development. Deletion of DDR1 attenuated atherogenesis and resulted in the formation of matrix-rich plaques...
  68. ncbi Discoidin domain receptor 2 inhibits fibrillogenesis of collagen type 1
    Cosmin Mihai
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Mol Biol 361:864-76. 2006
    ..Our results demonstrate a novel and important functional role of the DDR2 ECD that may contribute to collagen regulation via modulation of fibrillogenesis...
  69. ncbi [Structural basis for biological processes activated by collagen-binding proteins]
    Noritaka Nishida
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Seikagaku 80:483-92. 2008
  70. pmc Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis
    Wataru Matsuyama
    Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Am J Pathol 168:866-77. 2006
    ..We propose that DDR1 contributes to fibroblast survival in the tissue microenvironment of IPF and that DDR1 up-regulation may occur in other fibroproliferative lung diseases as well...
  71. ncbi Fusion expression of DDR2 extracellular domain in insect cells and its purification and function characterization
    Wei Zhang
    Department of Microbiology, The Fourth Military Medical University, Xi an, Shaanxi 710032, P R China
    J Cell Biochem 102:41-51. 2007
    ..These findings suggested that the expressed DR inhibited the activity of natural DDR2 and relevant MMP-1 and MMP-2 expression in RA synoviocytes and NIH3T3 cells provoked by collagen II...
  72. ncbi Altered fibroblast function following myocardial infarction
    Christina E Squires
    Division of Cardiothoracic Surgery Research, Room 629, Strom Thurmond Research Building, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA
    J Mol Cell Cardiol 39:699-707. 2005
    ..Additionally, our model provides a novel in vitro template for examining the cellular mechanisms of wound healing and scar formation post-MI...
  73. ncbi Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions
    Lee K Landeen
    Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 292:H2698-711. 2007
    ..These results highlight the importance of demonstrating CFb culture purity in functional studies of S1P and also identify conditions that modulate S1P receptor expression in CFbs...
  74. ncbi Natural compounds from Danshen suppress the activity of hepatic stellate cells
    Seong Hwan Oh
    Department of Family Medicine, Korea University, College of Medicine, Seoul, Korea
    Arch Pharm Res 29:762-7. 2006
    ....
  75. ncbi Suppression of discoidin domain receptor 1 by RNA interference attenuates lung inflammation
    Wataru Matsuyama
    Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, Kagoshima, Japan
    J Immunol 176:1928-36. 2006
    ..Considered together, we propose that DDR1 contributes to the development of bleomycin-induced pulmonary inflammation and fibrosis...
  76. ncbi Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture
    Min Chul Seo
    Department of Pharmacology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea
    J Neurosci Res 86:1087-95. 2008
    ..Our results suggest that collagen can induce inflammatory activation of brain microglia and that DDR1 mediates this effect of collagen in an integrin-independent manner...
  77. ncbi Extracellular matrix signaling through growth factor receptors during wound healing
    Kien T Tran
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Wound Repair Regen 12:262-8. 2004
    ..We provide a model framework for further studies into this emerging class of signals...
  78. ncbi Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes
    Yasuhiro Ebihara
    Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, 29401 5799, USA
    Exp Hematol 34:219-29. 2006
    ..Because myofibroblasts are thought to be an activated form of fibroblasts, we tested the hypothesis that fibroblasts are derived from HSCs...
  79. ncbi Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis
    Lin Xu
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    Arthritis Rheum 56:2663-73. 2007
    ..To investigate the role of the collagen receptor discoidin domain receptor 2 (DDR-2) in the pathogenesis of osteoarthritis (OA)...
  80. doi KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling
    Heidi N Hilton
    Development Group, Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Biochim Biophys Acta 1783:383-93. 2008
    ..Thus KIBRA may play a role in how the reproductive state influences the mammary epithelial cell to respond to changing cell-context information, such as experienced during the tissue remodeling events of mammary gland development...
  81. ncbi Function of discoidin domain receptor I in HGF-induced branching tubulogenesis of MDCK cells in collagen gel
    Chau Zen Wang
    Institute of Basic Medical Sciences, and Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    J Cell Physiol 203:295-304. 2005
    ..These results indicate that DDR1 plays important role in regulation of HGF-induced branching tubulogenesis by modulating cell proliferation, survival, and cell migration...
  82. pmc In vitro hematopoietic and endothelial potential of flk-1(-/-) embryonic stem cells and embryos
    A C Schuh
    Department of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5G 2C4
    Proc Natl Acad Sci U S A 96:2159-64. 1999
    ..Our results suggest that hematopoietic/endothelial progenitors arise independently of Flk-1, but that their subsequent migration and expansion require a Flk-1-mediated signal...
  83. ncbi Functional analysis of discoidin domain receptor 1: effect of adhesion on DDR1 phosphorylation
    Corine G M L'Hôte
    ICRF Molecular Oncology Laboratories, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    FASEB J 16:234-6. 2002
    ..This is the first RTK whose kinetics of phosphorylation is dependent on cellular context. The interaction of the cells with the matrix, rather than cell-cell contact, is probably responsible for the inhibition of phosphorylation...
  84. ncbi Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2
    Elvira Olaso
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:3606-13. 2002
    ..These data establish a role for DDR2 in critical events during wound repair...
  85. pmc DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells
    E Olaso
    Division of Liver Diseases and Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 108:1369-78. 2001
    ..Moreover, type I collagen-dependent upregulation of DDR2 expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity...
  86. ncbi Discoidin domain receptor 1 isoform-a (DDR1alpha) promotes migration of leukocytes in three-dimensional collagen lattices
    H Kamohara
    Laboratory of Molecular Immunoregulation, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    FASEB J 15:2724-6. 2001
    ..Consequently, we propose that the interaction of DDR1alpha with collagen of the ECM results in a requisite intracellular signaling that enables leukocytes to migrate in a tissue microenvironment and participate in host defense...
  87. pmc Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
    M G Achen
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 95:548-53. 1998
    ..In addition, VEGF-D is a mitogen for endothelial cells. The structural and functional similarities between VEGF-D and VEGF-C define a subfamily of the VEGFs...
  88. ncbi Mapping of epitopes in discoidin domain receptor 1 critical for collagen binding
    C A Curat
    Laboratory of Extracellular Matrix Signaling and Tumor Invasion, Georg-Speyer-Haus-Institute for Biomedical Research, Johann Wolfgang von Goethe University Frankfurt, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt, Germany
    J Biol Chem 276:45952-8. 2001
    ..Using these results, we were able to predict key sites in the collagen-binding epitope of DDR1 and to suggest a potential mechanism of signaling...
  89. ncbi Differential expression of vascular endothelial growth factor and its receptor mRNAs in the mouse uterus around the time of implantation
    I Chakraborty
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    J Endocrinol 147:339-52. 1995
    ..abstract truncated at 400 words)..
  90. pmc Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons
    R S Bhatt
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021 6399, USA
    Genes Dev 14:2216-28. 2000
    ..Our results therefore indicate that collagen-DDR1 signaling is essential for granule neuron axon formation and further suggest a unique role of pia in cerebellar cortex histogenesis...
  91. ncbi Isolation of the complementary DNA encoding a mouse heparin-binding growth factor receptor with the use of a unique kinase insert sequence
    O Katoh
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 53:1136-41. 1993
    ..The relative amounts of these mRNAs were different depending on the organs examined. Thus, these gene products may have different biological functions in organ development including the central nervous system...
  92. ncbi Coordinate expression of vascular endothelial growth factor receptor-1 (flt-1) and its ligand suggests a paracrine regulation of murine vascular development
    G Breier
    Max Planck Institut fur Physiologische und Klinische Forschung, Bad Nauheim, Germany
    Dev Dyn 204:228-39. 1995
    ..The data are consistent with the hypothesis that VEGF and its receptors have an important function both in the differentiation of the endothelial lineage and in the neovascularization of developing organs, and act in a paracrine fashion...
  93. ncbi Direct visualization of renal vascular morphogenesis in Flk1 heterozygous mutant mice
    B Robert
    Department of Comparative Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Am J Physiol 275:F164-72. 1998
    ....
  94. ncbi A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cell 89:981-90. 1997
    ....
  95. ncbi The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma
    A Sawano
    Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, 108, Japan
    Biochem Biophys Res Commun 238:487-91. 1997
    ..These results strongly suggest that Tyr-1169 on Flt-1 is a major binding site for PLCgamma and important for Flt-1 signal transduction within the cell...
  96. ncbi Two functional forms of vascular endothelial growth factor receptor-2/Flk-1 mRNA are expressed in normal rat retina
    Y Wen
    Department of Medicine, West Los Angeles VA Medical Center, California, USA
    J Biol Chem 273:2090-7. 1998
    ....
  97. ncbi Reactive oxygen species accelerate production of vascular endothelial growth factor by advanced glycation end products in RAW264.7 mouse macrophages
    Yoshishige Urata
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan
    Free Radic Biol Med 32:688-701. 2002
    ..These results suggest an important role for AGEs in stimulation of the development of angiogenesis observed in diabetic complications, and that ROS accelerates the AGE-stimulated VEGF expression...
  98. ncbi Discoidin domain receptor 1 controls growth and adhesion of mesangial cells
    Cyrile A Curat
    Georg Speyer Haus, Institute for Biomedical Research, Frankfurt am Main, Germany
    J Am Soc Nephrol 13:2648-56. 2002
    ..This is the first evidence indicating that DDR1 could be involved in the proliferative stage of renal disorders...
  99. ncbi Shear stress induces expression of vascular endothelial growth factor receptor Flk-1/KDR through the CT-rich Sp1 binding site
    Takeo Abumiya
    National Cardiovascular Center Research Institute, Osaka, Japan
    Arterioscler Thromb Vasc Biol 22:907-13. 2002
    ..These results suggest that shear stress induces Flk-1/KDR expression through the CT-rich Sp1 binding site...
  100. ncbi Interaction of discoidin domain receptor 1 isoform b (DDR1b) with collagen activates p38 mitogen-activated protein kinase and promotes differentiation of macrophages
    Wataru Matsuyama
    Laboratory of Molecular Immunoregulation, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    FASEB J 17:1286-8. 2003
    ..Thus, DDR1b in response to collagen transduces signals that promote maturation/differentiation of HLA-DR-positive antigen-presenting cells and contributes to the development of adaptive immunity in a tissue microenvironment...
  101. ncbi Adhesion activity of fetal gonadal cells to EGF and discoidin domains of milk fat globule-EGF factor 8 (MFG-E8), a secreted integrin-binding protein which is transiently expressed in mouse early gonadogenesis
    Maki Ishii
    Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Anat Embryol (Berl) 209:485-94. 2005
    ..5-dpc gonads. These findings therefore suggest that MFG-E8 mediates the cell-to-cell interaction among several somatic cell types and germ cells in mouse early gonadogenesis...

Research Grants62

  1. Characterization of Ocular Neural Stem Cells
    Iqbal Ahmad; Fiscal Year: 2004
    ..In addition, we will determine the distribution of mitogen receptors in different sub-populations of ocular progenitors in order to understand the basis of their responsiveness ..
  2. DDR1 controls tumor homing in breast to bone metastasis
    Celso Gomez Sanchez; Fiscal Year: 2004
    ..A survey of the CRISP database showed that the NIH currently funds no other research on DDR1. ..
  3. MICROTUBULE/KERATIN INTERACTIONS DURING SPERMATOGENESIS
    ABRAHAM KIERSZENBAUM; Fiscal Year: 2002
    ..Engineering mouse models in which the expression of K9 is null, is important for both reproductive biology and cancer research. ..
  4. PHOSPHATIDYLSERINE-SPECIFIC RECEPTOR FOR APOPTOTIC CELLS
    Valerie Fadok; Fiscal Year: 2004
    ..The investigators hypothesize that PS recognition has been preserved throughout phylogeny as an effective mechanism mediating the removal of apoantibodies. ..
  5. Clinical trial of self complementary AAV8-mediated gene transfer for hemophilia B
    Andrew M Davidoff; Fiscal Year: 2010
    ....
  6. Hedgehog, Patched, and Gli in Medulloblastoma
    Howard Weiner; Fiscal Year: 2007
    ..This system provides a unique opportunity to investigate an in vivo animal model of childhood medulloblastoma, and to determine the roles of Ptc and Gli in tumorigenesis. ..
  7. New Mexico NIEHS Center
    Scott Burchiel; Fiscal Year: 2006
    ..S.-Mexico community partners. ..
  8. Clinical trial of self complementary AAV8-mediated gene transfer for hemophilia B
    Andrew Davidoff; Fiscal Year: 2009
    ....
  9. rAAV-Mediated Gene Therapy for Hemophillia B
    Andrew Davidoff; Fiscal Year: 2009
    ..Data generated from these studies will provide insight and preclinical data for a gene therapy trial not only for hemophilia B, but also for other potential trials in which AAV-mediated liver-targeted gene therapy might be employed. ..
  10. IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS
    Scott Burchiel; Fiscal Year: 2001
    ..Finally, in Aim 4 we will assess the role of monocyte and P450 expression by Western blot and RT-PCR methods in subsets of HPBMC and human cell lines (above). ..
  11. IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS
    Scott Burchiel; Fiscal Year: 1993
    ..The results of these studies are likely to give broad insights into mechanisms of immunotoxicity produced by environmental and other agents that alter Ca+2 homeostasis and signal transduction in lymphoid cells...