integrins

Summary

Summary: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.

Top Publications

  1. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
  2. ncbi Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
  3. doi Integrins in cancer: biological implications and therapeutic opportunities
    Jay S Desgrosellier
    Department of Pathology, Moores University of California at San Diego Cancer Center, La Jolla, 92093 0803, United States
    Nat Rev Cancer 10:9-22. 2010
  4. doi The final steps of integrin activation: the end game
    Sanford J Shattil
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Mol Cell Biol 11:288-300. 2010
  5. doi The tail of integrins, talin, and kindlins
    Markus Moser
    Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Science 324:895-9. 2009
  6. ncbi Integrin signaling
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 285:1028-32. 1999
  7. doi Adhesion signaling - crosstalk between integrins, Src and Rho
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Cell Sci 122:1059-69. 2009
  8. doi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
  9. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
  10. pmc Integrins in cell migration
    Anna Huttenlocher
    Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wsconsin 53706, USA
    Cold Spring Harb Perspect Biol 3:a005074. 2011

Detail Information

Publications311 found, 100 shown here

  1. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
    In their roles as major adhesion receptors, integrins signal across the plasma membrane in both directions...
  2. ncbi Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
    ....
  3. doi Integrins in cancer: biological implications and therapeutic opportunities
    Jay S Desgrosellier
    Department of Pathology, Moores University of California at San Diego Cancer Center, La Jolla, 92093 0803, United States
    Nat Rev Cancer 10:9-22. 2010
    ..The importance of integrins in several cell types that affect tumour progression has made them an appealing target for cancer therapy...
  4. doi The final steps of integrin activation: the end game
    Sanford J Shattil
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Mol Cell Biol 11:288-300. 2010
    Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby contributing to embryonic development and diseases such ..
  5. doi The tail of integrins, talin, and kindlins
    Markus Moser
    Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Science 324:895-9. 2009
    b>Integrins are transmembrane cell-adhesion molecules that carry signals from the outside to the inside of the cell and vice versa...
  6. ncbi Integrin signaling
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 285:1028-32. 1999
    ..The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals ..
  7. doi Adhesion signaling - crosstalk between integrins, Src and Rho
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Cell Sci 122:1059-69. 2009
    ..b>Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly...
  8. doi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
    ..As migration on two-dimensional substrates naturally overemphasizes the role of adhesion, the contribution of integrins during three-dimensional movement of leukocytes within tissues has remained controversial...
  9. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
    ..focal and fibrillar adhesions characterized on 2D substrates in their content of alpha5beta1 and alphavbeta3 integrins, paxillin, other cytoskeletal components, and tyrosine phosphorylation of focal adhesion kinase (FAK)...
  10. pmc Integrins in cell migration
    Anna Huttenlocher
    Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wsconsin 53706, USA
    Cold Spring Harb Perspect Biol 3:a005074. 2011
    ..Finally, we address mechanisms of adhesion assembly and disassembly and the role of adhesion in cellular polarity...
  11. ncbi Retinoic acid imprints gut-homing specificity on T cells
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunity 21:527-38. 2004
    ..These findings revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells...
  12. doi Integrins: masters and slaves of endocytic transport
    Patrick T Caswell
    Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, G61 3BX, Scotland
    Nat Rev Mol Cell Biol 10:843-53. 2009
    ..in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis ..
  13. pmc The C terminus of talin links integrins to cell cycle progression
    Pengbo Wang
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester M13 9PT, England, UK
    J Cell Biol 195:499-513. 2011
    b>Integrins are cell adhesion receptors that sense the extracellular matrix (ECM) environment...
  14. pmc Integrins in angiogenesis and lymphangiogenesis
    Christie J Avraamides
    Moores UCSD Cancer Center, 3, 855 Health Sciences Drive, La Jolla, California 92092 0819, USA
    Nat Rev Cancer 8:604-17. 2008
    ..Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a family of cell surface receptors whose ligands are extracellular matrix proteins and ..
  15. pmc Integrins
    Malgorzata Barczyk
    Department of Biomedicine, University of Bergen, Norway
    Cell Tissue Res 339:269-80. 2010
    b>Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes...
  16. pmc Vinculin controls focal adhesion formation by direct interactions with talin and actin
    Jonathan D Humphries
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester M13 9PT, England, UK
    J Cell Biol 179:1043-57. 2007
    ..The vinculin tail, however, is responsible for the functional link of FAs to the actin cytoskeleton. We propose a new model that explains how vinculin orchestrates FAs...
  17. pmc Integrin ligands at a glance
    Jonathan D Humphries
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 119:3901-3. 2006
  18. doi HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    James Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:301-9. 2008
    ..On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1...
  19. ncbi Integrin signalling during tumour progression
    Wenjun Guo
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences, Sloan Kettering Institute Cornell University, New York, New York, USA
    Nat Rev Mol Cell Biol 5:816-26. 2004
    ..There is increasing evidence that certain integrins associate with receptor tyrosine kinases (RTKs) to activate signalling pathways that are necessary for tumour ..
  20. ncbi The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    J S Munger
    Department of Medicine, and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6402, USA
    Cell 96:319-28. 1999
    ..These data identify a novel mechanism for locally regulating TGF beta 1 function in vivo by regulating expression of the alpha v beta 6 integrin...
  21. pmc The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
    Nicholas J Anthis
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    EMBO J 28:3623-32. 2009
    Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that uniquely mediate inside-out signal transduction, whereby adhesion to the extracellular matrix is activated from within the cell by ..
  22. ncbi Complexes of tetraspanins with integrins: more than meets the eye
    F Berditchevski
    CRC Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, B15 2TA, UK
    J Cell Sci 114:4143-51. 2001
    ..A substantial fraction of tetraspanins colocalise with integrins in various intracellular vesicular compartments...
  23. doi The mechanical integrin cycle
    Eileen Puklin-Faucher
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Cell Sci 122:179-86. 2009
    ..As the major force-bearing adhesion-receptor protein, integrins have a central role in how cells sense and respond to the mechanics of their surroundings...
  24. ncbi Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    M Tamura
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Science 280:1614-7. 1998
    ..Overexpression of FAK partially antagonized the effects of PTEN. Thus, PTEN phosphatase may function as a tumor suppressor by negatively regulating cell interactions with the extracellular matrix...
  25. pmc The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins
    Christophe Guilluy
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Cell Biol 13:722-7. 2011
    ..The application of force on integrins triggers cytoskeletal rearrangements and growth of the associated adhesion complex, resulting in increased ..
  26. ncbi Imaging of integrins as biomarkers for tumor angiogenesis
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, California, USA
    Curr Pharm Des 14:2943-73. 2008
    ..The design, optimization, and characterization of imaging agents targeting integrins will be presented and areas needing extensive future research effort will be discussed...
  27. pmc Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    K M Hodivala-Dilke
    Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 103:229-38. 1999
    beta3 integrins have been implicated in a wide variety of functions, including platelet aggregation and thrombosis (alphaIIbbeta3) and implantation, placentation, angiogenesis, bone remodeling, and tumor progression (alphavbeta3)...
  28. ncbi Structural basis of collagen recognition by integrin alpha2beta1
    J Emsley
    Department of Biochemistry, University of Leicester, United Kingdom
    Cell 101:47-56. 2000
    ..The structural features observed here may represent a general mechanism for integrin-ligand recognition...
  29. doi Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship
    Pierre Jean Wipff
    Laboratory of Cell Biophysics, Bâtiment SG AA B143, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Eur J Cell Biol 87:601-15. 2008
    b>Integrins are crucial for the ability of cells to sense mechanical perturbations and to transmit intracellular stress to their environment...
  30. pmc Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
    Karl E Kadler
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Curr Opin Cell Biol 20:495-501. 2008
    ..I-containing fibrils do not form in the absence of fibronectin, fibronectin-binding and collagen-binding integrins, and collagen V...
  31. ncbi Integrin-regulated FAK-Src signaling in normal and cancer cells
    Satyajit K Mitra
    The Scripps Research Institute, Department of Immunology, IMM21 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 18:516-23. 2006
    b>Integrins can alter cellular behavior through the recruitment and activation of signaling proteins such as non-receptor tyrosine kinases including focal adhesion kinase (FAK) and c-Src that form a dual kinase complex...
  32. ncbi The integrin-growth factor receptor duet
    Naved Alam
    Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 213:649-53. 2007
    Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation...
  33. pmc Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo
    Catherine C Park
    Departments of Radiation Oncology and Pathology, University of California San Francisco Mt Zion Cancer Center, 1600 Divisadero Street, San Francisco, CA 94143 1708, USA
    Cancer Res 66:1526-35. 2006
    ..Our findings indicate that beta(1) integrin is a promising therapeutic target, and that the three-dimensional lrECM culture assay can be used to effectively distinguish malignant and normal tissue response to therapy...
  34. pmc Integrins and extracellular matrix in mechanotransduction
    Martin Alexander Schwartz
    Departments of Microbiology, Cell Biology, and Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Cold Spring Harb Perspect Biol 2:a005066. 2010
    b>Integrins bind extracellular matrix fibrils and associate with intracellular actin filaments through a variety of cytoskeletal linker proteins to mechanically connect intracellular and extracellular structures...
  35. pmc Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
    Mika Shimonaka
    Bayer Chair, Dept of Molecular Immunology and Allergy, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 161:417-27. 2003
    ..Spa1 effectively suppressed this polarization after SLC treatment. This unique characteristic of Rap1 may control chemokine-induced lymphocyte extravasation...
  36. doi Unique and redundant functions of integrins in the epidermis
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    FASEB J 24:4133-52. 2010
    ..Epidermal adhesion is mediated primarily by integrins, cell-surface receptors that connect the extracellular matrix to the cytoskeleton...
  37. doi Integrins: the keys to unlocking angiogenesis
    Rita Silva
    Adhesion and Angiogenesis Group, Centre for Tumour Biology, Cancer Research UK Clinical Centre, Institute of Cancer, Barts and The London and Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London UK
    Arterioscler Thromb Vasc Biol 28:1703-13. 2008
    ..b>Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them ..
  38. ncbi Cell-matrix adhesion
    Allison L Berrier
    Katrina Visiting Faculty Program, National Center on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland, USA
    J Cell Physiol 213:565-73. 2007
    ..Many of these interactions involve transmembrane integrin receptors. Integrins cluster in specific cell-matrix adhesions to provide dynamic links between extracellular and intracellular ..
  39. pmc The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:20877-82. 2009
    ..The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission...
  40. pmc Integrin-dependent actomyosin contraction regulates epithelial cell scattering
    Johan de Rooij
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 171:153-64. 2005
    ..is enhanced on collagen and fibronectin, as compared with laminin1, suggesting possible cross talk between integrins and cell-cell junctions...
  41. doi Integrins in immunity
    Rachel Evans
    Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:215-25. 2009
    ..the same biological rules as many other cell types, and this holds true particularly for the functioning of the integrins on these cells...
  42. pmc Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
    Akeila Bellahcene
    Metastasis Research Laboratory, University of Liege, Tour de Pathologie, 1, Bat B23, Sart Tilman via 4000 Liege, Belgium
    Nat Rev Cancer 8:212-26. 2008
    ....
  43. ncbi Integrin activation
    David A Calderwood
    Department of Pharmacology, Yale University School of Medicine, Sterling Hall of Medicine, New Haven, CT 06520, USA
    J Cell Sci 117:657-66. 2004
    ..Recent studies have shed light on the final intracellular steps in this process and have revealed a vital role for the cytoskeletal protein talin...
  44. doi Signal co-operation between integrins and other receptor systems
    Charles H Streuli
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, U K
    Biochem J 418:491-506. 2009
    ..In the present review we explore how one class of adhesion receptor, the integrins, co-operate with other types of receptor to control diverse aspects of cell fate...
  45. pmc Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination
    S Raghavan
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biol 150:1149-60. 2000
    The major epidermal integrins are alpha3beta1 and hemidesmosome-specific alpha6beta4; both share laminin 5 as ligand...
  46. pmc Structure and mechanics of integrin-based cell adhesion
    M Amin Arnaout
    Nephrology Division, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, United States
    Curr Opin Cell Biol 19:495-507. 2007
    b>Integrins are alpha/beta heterodimeric adhesion glycoprotein receptors that regulate a wide variety of dynamic cellular processes such as cell migration, phagocytosis, and growth and development...
  47. pmc The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission
    Fatima Nawaz
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 7:e1001301. 2011
    ..Understanding the structural features that characterize early-transmitting gp120s may aid in the design of an effective gp120-based subunit vaccine...
  48. pmc Integrins: roles in cancer development and as treatment targets
    H Jin
    John and Rebecca Moores Comprehensive Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0912, USA
    Br J Cancer 90:561-5. 2004
    ..Several integrins play key roles in promoting tumour angiogenesis and tumour metastasis...
  49. pmc Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth
    Dalit Barkan
    Department of Biology, Faculty of Sciences, Haifa University, Haifa, Israel
    Eur J Cancer 46:1181-8. 2010
    ..The roles of integrins, fibronectin, and collagen are discussed, as are factors that can change the ECM...
  50. ncbi Fibronectin at a glance
    Roumen Pankov
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 115:3861-3. 2002
  51. ncbi Paxillin and focal adhesion signalling
    C E Turner
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    Nat Cell Biol 2:E231-6. 2000
    ..Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals...
  52. doi The role of integrin binding sites in fibronectin matrix assembly in vivo
    Michael Leiss
    Max Planck Institute of Biochemistry, Department of Molecular Medicine, 82152 Martinsried, Germany
    Curr Opin Cell Biol 20:502-7. 2008
    ..Fibrillogenesis is initiated and governed by cell surface integrins that bind to specific sites in the FN molecule...
  53. doi Important role of integrins in the cancer biology
    R Rathinam
    Department of Biochemistry and Molecular Biology, Stanley S Scott Cancer Center, LSU School of Medicine, 1901 Perdido Street, New Orleans, LA, 70112, USA
    Cancer Metastasis Rev 29:223-37. 2010
    Adhesion of breast cancer cells is supported by various integrins. Cell adhesion is critical for maintenance of both three-dimensional and normal function of these tissues...
  54. ncbi Rap1: a turnabout for the crosstalk between cadherins and integrins
    Saverio Francesco Retta
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, I 10126 Torino, Italy
    Eur J Cell Biol 85:283-93. 2006
    The coordinate modulation of the cellular functions of cadherins and integrins plays an essential role in fundamental physiological and pathological processes, including morphogenesis, tissue differentiation and renewal, wound healing, ..
  55. doi Integrins as therapeutic targets
    Simon L Goodman
    Department of Cellular Pharmacology Oncology Platform, Merck KGaA, Frankfurterstrasse 250, 64271 Darmstadt, Germany
    Trends Pharmacol Sci 33:405-12. 2012
    b>Integrins are a large family of molecules that are central regulators in multicellular biology. They orchestrate cell-cell and cell-extracellular matrix (ECM) adhesive interactions from embryonic development to mature tissue function...
  56. ncbi Integrins in mechanotransduction
    Akira Katsumi
    Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 279:12001-4. 2004
    ..Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces...
  57. pmc Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site
    Saji Oommen
    Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 286:1083-92. 2011
    ..This interaction is biologically important because it mediates in vitro endothelial cell tube formation, wound healing, and cancer cell invasion. These novel findings identify EYP as a potential site for directed pharmacotherapy...
  58. ncbi Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility
    Lindsay Gillan
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Res 62:5358-64. 2002
    ..Furthermore, alpha(V)beta(3) integrin, but not beta(1) integrins, colocalizes to the focal adhesion plaques formed on PN...
  59. ncbi The interplay between Src and integrins in normal and tumor biology
    Martin P Playford
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Oncogene 23:7928-46. 2004
    ....
  60. ncbi FAK integrates growth-factor and integrin signals to promote cell migration
    D J Sieg
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Cell Biol 2:249-56. 2000
    ..Our results establish that FAK is an important receptor-proximal link between growth-factor-receptor and integrin signalling pathways...
  61. ncbi Structural basis for ligand recognition by integrins
    Junichi Takagi
    Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Opin Cell Biol 19:557-64. 2007
    b>Integrins, the major cell surface receptors mediating cell-extracellular matrix (ECM) adhesion, are central to the basic physiology underlying all multicellular organisms...
  62. pmc Integrins and cell-fate determination
    Charles H Streuli
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 122:171-7. 2009
    All cellular processes are determined by adhesive interactions between cells and their local microenvironment. Integrins, which constitute one class of cell-adhesion receptor, are multifunctional proteins that link cells to the ..
  63. pmc Synergistic control of cell adhesion by integrins and syndecans
    Mark R Morgan
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Nat Rev Mol Cell Biol 8:957-69. 2007
    ..The integrins and the syndecans are two adhesion receptor families that mediate adhesion, but their relative and functional ..
  64. pmc Focal adhesion disassembly requires clathrin-dependent endocytosis of integrins
    Wei Ting Chao
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, 1 Baylor Plaza, BCM335, RM T419, Houston, TX 77030, USA
    FEBS Lett 583:1337-43. 2009
    ..show that adhesion turnover is mediated through dynamin- and clathrin-dependent endocytosis of activated beta1 integrins. Consistent with this, clathrin and the clathrin adaptors AP-2 and disabled-2 (DAB2) distribute along with ..
  65. pmc Functional atlas of the integrin adhesome
    Ronen Zaidel-Bar
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
    Nat Cell Biol 9:858-67. 2007
    ..We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions...
  66. pmc Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1
    X Z Huang
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, San Francisco, California 94143 0854, USA
    Mol Cell Biol 20:5208-15. 2000
    ..Our results suggest that the alpha9 integrin is required for the normal development of the lymphatic system, including the thoracic duct, and that alpha9 deficiency could be one cause of congenital chylothorax...
  67. ncbi A novel, tissue-specific integrin subunit, beta nu, expressed in the midgut of Drosophila melanogaster
    G H Yee
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Development 118:845-58. 1993
    The integrins are a family of cell surface receptors for extracellular matrix proteins and counter-receptors on other cells...
  68. ncbi Integrins and anoikis
    S M Frisch
    Burnham Institute, La Jolla Cancer Research Center, CA 92037, USA
    Curr Opin Cell Biol 9:701-6. 1997
    ..Focal adhesion kinase, when activated by integrins, can suppress anoikis...
  69. ncbi Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
    C Berlin
    Department of Pathology, Stanford University, California 94305
    Cell 74:185-95. 1993
    ..Alpha 4 beta 7 can also bind VCAM-1, but this requires greater integrin activation than binding to MAdCAM-1. The findings imply a selective role for the interaction of alpha 4 beta 7 and MAdCAM-1 lymphocyte in homing to mucosal sites...
  70. pmc Role of integrins in regulating epidermal adhesion, growth and differentiation
    Fiona M Watt
    Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 21:3919-26. 2002
    ..expression is altered when the epidermis is damaged or diseased, and there is good evidence that specific integrins can contribute positively or negatively to pathogenesis...
  71. ncbi Regulation of integrin function by the urokinase receptor
    Y Wei
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 273:1551-5. 1996
    ..The urokinase-type plasminogen activator receptor (uPAR) and integrins formed stable complexes that both inhibited native integrin adhesive function and promoted adhesion to ..
  72. pmc The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1
    Nicholas E Vlahakis
    Lung Biology Center, University of California San Francisco, San Francisco, California, 94143 2922, USA
    J Biol Chem 280:4544-52. 2005
    ..The interaction between alpha9beta1 and VEGF-C and/or -D may begin to explain the abnormal lymphatic phenotype of the alpha9 knock-out mice...
  73. ncbi Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
    Motomu Shimaoka
    The Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 112:99-111. 2003
    ..Pulling down on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in affinity...
  74. pmc Kindlin-2 controls bidirectional signaling of integrins
    Eloi Montanez
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Genes Dev 22:1325-30. 2008
    ..We found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindlin-2 is required for talin-induced integrin activation...
  75. pmc Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain
    Adam L Feire
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:15470-5. 2004
    ..entry, HCMV induces cellular morphological changes and signaling cascades consistent with engagement of cellular integrins; however, HCMV structural proteins do not possess the widely used RGD integrin-binding motif...
  76. ncbi Requirement of vascular integrin alpha v beta 3 for angiogenesis
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 264:569-71. 1994
    ..These findings suggest that alpha v beta 3 may be a useful therapeutic target for diseases characterized by neovascularization...
  77. pmc The integrins
    Yoshikazu Takada
    Department of Dermatology, University of California Davis School of Medicine, Second Avenue, Sacramento, CA 95817, USA
    Genome Biol 8:215. 2007
    The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands...
  78. pmc Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): role of heparan sulfate, DC-SIGN, integrins and signaling
    Nagaraj Kerur
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Virology 406:103-16. 2010
    ..In addition to the previously identified integrins alpha3beta1, alphavbeta3 and alphavbeta5, integrin alpha5beta1 was also utilized for infection...
  79. ncbi Role of integrins in cell invasion and migration
    John D Hood
    Scripps Research Institute, Departments of Immunology and Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Cancer 2:91-100. 2002
    ..The attachment is mediated by cell-surface receptors known as integrins, which bind to components of the extracellular matrix...
  80. pmc The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1
    Jeffrey C Nolz
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Biol 182:1231-44. 2008
    ..These findings identify a previously unknown mechanism by which the WAVE2 complex regulates TCR signaling to Rap1 and integrin activation...
  81. doi Outside-in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation?
    Eliane J Muller
    Molecular Dermatology, Institute of Animal Pathology and DermFocus, Vetsuisse Faculty, University of Bern, Bern, Switzerland
    J Invest Dermatol 128:501-16. 2008
    ..Recent insights into adhesion receptor signaling now propose that integrins, but also cadherins, can centrally control these programs...
  82. ncbi Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion
    H Gardner
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
    Dev Biol 175:301-13. 1996
    ..Further in vitro analysis of cell spreading and migration suggests that alpha 1 beta 1 is not required for binding to collagen I and implicates a third receptor, possibly integrin alpha 3 beta 1, in collagen I binding...
  83. pmc The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment
    Triantafyllos Chavakis
    Department of Internal Medicine I, University Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    J Exp Med 198:1507-15. 2003
    ..of RAGE with the beta2-integrin Mac-1 and, to a lower extent, with p150,95 but not with LFA-1 or with beta1-integrins. The RAGE-Mac-1 interaction was augmented by the proinflammatory RAGE-ligand, S100-protein...
  84. pmc Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts
    K P McHugh
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 105:433-40. 2000
    ..Thus, although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteoclast function...
  85. ncbi Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
    J O Lee
    Laboratory of X ray Crystallography, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115
    Cell 80:631-8. 1995
    ..We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain...
  86. ncbi Signalling via integrins: implications for cell survival and anticancer strategies
    Stephanie Hehlgans
    OncoRay, Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74 PF 86, 01307 Dresden, Germany
    Biochim Biophys Acta 1775:163-80. 2007
    ..b>Integrins are heterodimeric cell-surface molecules that on one side link the actin cytoskeleton to the cell membrane and ..
  87. ncbi Integrin traffic
    Teijo Pellinen
    VTT Medical Biotechnology, FIN 20520 Turku, Finland
    J Cell Sci 119:3723-31. 2006
    ..migration and the maintenance of cell polarity are all processes that depend on the correct targeting of integrins and the dynamic remodelling of integrin-containing adhesion sites...
  88. pmc Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions
    Francesco J Conti
    The Scripps Research Institute, Department of Cell Biology and Institute of Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    Development 136:3597-606. 2009
    Talin 1 and 2 connect integrins to the actin cytoskeleton and regulate the affinity of integrins for ligands...
  89. ncbi The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing
    Yung Feng Liao
    Center for Engineering in Medicine and Surgical Service, Massachusetts General Hospital and Harvard Medical School, the Shriners Burns Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 277:14467-74. 2002
    ..Nonetheless, integrins that bind the EIIIA segment have not been identified...
  90. doi Integrins as therapeutic targets: lessons and opportunities
    Dermot Cox
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Nat Rev Drug Discov 9:804-20. 2010
    The integrins are a large family of cell adhesion molecules that are essential for the regulation of cell growth and function...
  91. ncbi Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours
    F A L M Eskens
    Erasmus Medical Center, Department of Medical Oncology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Cancer 39:917-26. 2003
    A single-agent dose escalating phase I and pharmacokinetic study with Cilengitide, an inhibitor of the integrins alphavbeta3 and alphavbeta5, was performed to determine its safety and toxicity...
  92. pmc Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton
    Shizhen Emily Wang
    Division of Tumor Cell Biology, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    Cancer Res 69:475-82. 2009
    ..transforming growth factor beta (TGF-beta) induced focal adhesion kinase (FAK)-dependent clustering of HER2 and integrins alpha(6), beta(1), and beta(4) in HER2-overexpressing mammary epithelial cells without altering the total and ..
  93. pmc Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8
    Liudmila S Chesnokova
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 106:20464-9. 2009
    ..of cells expressing gB and gHgL can be blocked by vitronectin or triggered by addition of soluble truncated integrins alphavbeta6 and alphavbeta8...
  94. ncbi Integrins in cell adhesion and signaling
    S K Akiyama
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Hum Cell 9:181-6. 1996
    ..The best characterized cell adhesion receptors are the integrins. Integrins comprise a family of more than 23 noncovalent, heterodimeric complexes consisting of an alpha and a ..
  95. pmc Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells
    Heather M Bill
    Van Andel Research Institute, 333 Bostwick Ave, SE, Grand Rapids, MI 49503, USA
    Mol Cell Biol 24:8586-99. 2004
    ..The ability of integrins to induce the activation of EGFR and its subsequent regulation of Erk and Akt activation permitted adhesion-..
  96. pmc Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 186:1044-59. 2011
    ....
  97. pmc Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development
    Arjan van der Flier
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 137:2439-49. 2010
    ..Here, we report on the roles of the alpha5 and alphav integrins, which are the major endothelial fibronectin receptors, in developmental angiogenesis...
  98. doi Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells
    Yannick D Benoit
    CIHR Team on Digestive Epithelium, Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Biochem Biophys Res Commun 399:434-9. 2010
    ..is expressed in human intestinal epithelial crypt cells (HIECs) and represents one of the major RGD-binding integrins expressed by these cells...
  99. pmc Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets
    Christopher S Stipp
    Departments of Biology and Molecular Physiology and Biophysics, 210 Iowa Avenue, BBE 236, University of Iowa, Iowa City, IA 52242, USA
    Expert Rev Mol Med 12:e3. 2010
    Within the integrin family of cell adhesion receptors, integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 make up a laminin-binding subfamily...
  100. pmc Kindlins in FERM adhesion
    Nikolay L Malinin
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, OH 44195, USA
    Blood 115:4011-7. 2010
    ..This review discusses recent progress in the studies of Kindlin protein family, emphasizing newly identified functions and potential mechanisms underlying differential activities of the family members...
  101. pmc Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain
    Aaron K Mobley
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Cell Sci 122:1842-51. 2009
    ..Collectively, these data identify essential functions for beta8 integrin in regulating neurovascular unit physiology in the post-natal mouse brain...

Research Grants90

  1. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 1999
    ..We propose, in this application, to examine a family of receptors for ECM proteins, the integrins, and the cell-matrix interactions in the human TM...
  2. BETA 1 INTEGRIN ANTAGONISM & RETINAL NEOVASCULARIZATION
    DONALD SENGER; Fiscal Year: 2001
    ..VEGF markedly induces expression of the alpha-1-beta-1, alpha-2-beta-1, and alpha- 5-beta-3 cell surface integrins in dermal microvascular endothelial cells (ECs), and antagonism of alpha-1-beta-1, alpha-2-beta-1, and alpha-5 ..
  3. Regulation of Integrins in Neovasculature Development
    Tatiana Byzova; Fiscal Year: 2009
    ..Angiogenesis is driven by Vascular Endothelial Growth Factor (VEGF) and cell adhesion receptors, integrins on endothelial and blood cells...
  4. Regulation of invadopodia formation in breast cancer cells
    Anthony J Koleske; Fiscal Year: 2010
    ..In turn, Arg phosphorylates cortactin to promote dynamic invadopodia-like cell edge protrusions. Integrins 1 and 3, and Arg are all upregulated in highly invasive breast cancer cells, and inhibiting Arg or cortactin ..
  5. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
    ..3) Assess the effect of the bicistronic Ad-uPAR-pl6 construct on the expression of integrins (particularly avlI3) and molecules involved in signaling pathways mediated by integrins...
  6. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D Milner; Fiscal Year: 2009
    ..tested by this proposal is that cerebral ischemia induces brain endothelial cell expression of the a51 and av3 integrins, and that fibronectin promotes cerebral angiogenesis, via these integrins...
  7. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D RICHARD MILNER; Fiscal Year: 2010
    ..tested by this proposal is that cerebral ischemia induces brain endothelial cell expression of the a51 and av3 integrins, and that fibronectin promotes cerebral angiogenesis, via these integrins...
  8. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2010
    ..Analysis of FAK Activity Binding interactions between extracellular matrix proteins such as fibronectin and integrins play fundamental roles during development by controlling cell adhesion, motility, and survival...
  9. Molecular Basis of ILK/PINCH Function in Cell Adhesion
    Jun Qin; Fiscal Year: 2010
    ..This interaction (cell adhesion) is mediated primarily by integrins, a group of heterodimeric transmembrane receptors that bind to ECM proteins via their extracellular domains...
  10. HANTAVIRUS CELL INTERACTIONS
    ERICH MACKOW; Fiscal Year: 2003
    ..We have recently determined that alphanubeta3 and alphaIIbbeta3 integrins are cellular receptors for pathogenic, but not non-pathogenic, hantaviruses and this finding directly relates ..
  11. Brain tumor angiogenesis: Integrin ceramide signaling
    Anat Erdreich Epstein; Fiscal Year: 2007
    ..Our goal in this proposal is to examine ceramide as a molecular target in inhibition of endothelial integrins alphavbeta3/beta5...
  12. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    MARY STEPP; Fiscal Year: 1992
    ..A family of integral membrane, cell- surface glycoproteins called integrins (formerly termed "fibronectin receptors", vitro-nectin receptors) function in mediating migration of cells ..
  13. Regulation of Vascular Tone and Ca channels by Integrins
    Michael Davis; Fiscal Year: 2009
    Interactions between vascular integrins and extracellular matrix (ECM) components of the blood vessel wall are important determinants of arteriolar tone and blood flow control...
  14. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy B Macklin; Fiscal Year: 2010
    ..We hypothesize that PLP interacts with integrins and neurotransmitter receptors, and thereby modulates a series of events in developing brain as well as in the ..
  15. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy Macklin; Fiscal Year: 2009
    ..We hypothesize that PLP interacts with integrins and neurotransmitter receptors, and thereby modulates a series of events in developing brain as well as in the ..
  16. Integrin Signaling in Nervous System Development
    Louis Reichardt; Fiscal Year: 2005
    ..Work over the past decade has shown that integrins mediate many of these interactions...
  17. Endothelial Cell Adhesion and Function on Smooth Muscle
    GEORGE TRUSKEY; Fiscal Year: 2009
    ..b>Integrins play an important role in endothelial force transduction...
  18. Endothelial Cell Adhesion and Function on Smooth Muscle
    George A Truskey; Fiscal Year: 2010
    ..b>Integrins play an important role in endothelial force transduction...
  19. Functional Roles of Integrins in Modulating Neural Responses of Mechanically Sens
    Michael Hadjiargyrou; Fiscal Year: 2007
    ..The current proposal seeks to investigate the functional roles that trans-membrane proteins, integrins, play in modulating neural responses of cutaneous mechanoreceptors...
  20. INTEGRIN SIGNALING PATHWAYS IN PROSTATE CANCER
    Lucia R Languino; Fiscal Year: 2010
    b>Integrins comprise a large family of cell surface receptors with critical roles in cancer cell proliferation, invasion and metastatic potential...
  21. Activation of alpha5beta3 integrin on blood and endothelial cells
    Tatiana Byzova; Fiscal Year: 2007
    The family of cell surface molecules, the integrins, mediates multiple physiological and pathological responses, including inflammation, atherosclerosis and cancer development, thrombus formation and angiogenesis...
  22. INTEGRIN REGULATION AND FUNCTIONS IN ADULT BRAIN
    Christine Gall; Fiscal Year: 2007
    ..Research in this program has shown that integrins are concentrated at synapses and influence neurotrophin expression, and glutamate receptor and ion channel ..
  23. Beta2 Integrin Activation and Signaling
    Vineet Gupta; Fiscal Year: 2007
    The leukocyte specific beta2 integrins are central to the biological function of these cells...
  24. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2010
    DESCRIPTION: Integrins are a broad family of cell surface adhesion and signaling molecules which link the extracellular matrix (ECM) to the cytoskeleton of the cell...
  25. Regulation of dendritic spine shape and synapse and dendrite stability by Arg
    Anthony J Koleske; Fiscal Year: 2010
    ..We seek to understand how integrins signal through Arg and its effectors to control the formation and maintenance of neural circuitry...