integrins

Summary

Summary: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.

Top Publications

  1. ncbi Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis
    Monique Clement
    INSERM U601, Institut de Biologie, 9 quai Moncousu, 44093 Nantes Cedex, France
    J Cell Sci 117:5059-69. 2004
  2. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
  3. ncbi Integrins in cancer: biological implications and therapeutic opportunities
    Jay S Desgrosellier
    Department of Pathology, Moores University of California at San Diego Cancer Center, La Jolla, 92093 0803, United States
    Nat Rev Cancer 10:9-22. 2010
  4. ncbi Integrins: masters and slaves of endocytic transport
    Patrick T Caswell
    Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, G61 3BX, Scotland
    Nat Rev Mol Cell Biol 10:843-53. 2009
  5. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
  6. ncbi Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
  7. ncbi HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    James Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:301-9. 2008
  8. ncbi Integrin signaling
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 285:1028-32. 1999
  9. ncbi Integrins
    Malgorzata Barczyk
    Department of Biomedicine, University of Bergen, Norway
    Cell Tissue Res 339:269-80. 2010
  10. ncbi Adhesion signaling - crosstalk between integrins, Src and Rho
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Cell Sci 122:1059-69. 2009

Research Grants

  1. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 1999
  2. BETA 1 INTEGRIN ANTAGONISM & RETINAL NEOVASCULARIZATION
    DONALD SENGER; Fiscal Year: 2001
  3. Regulation of Integrins in Neovasculature Development
    Tatiana Byzova; Fiscal Year: 2009
  4. Regulation of invadopodia formation in breast cancer cells
    Anthony J Koleske; Fiscal Year: 2010
  5. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
  6. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D Milner; Fiscal Year: 2009
  7. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D RICHARD MILNER; Fiscal Year: 2010
  8. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2010
  9. Molecular Basis of ILK/PINCH Function in Cell Adhesion
    Jun Qin; Fiscal Year: 2010
  10. HANTAVIRUS CELL INTERACTIONS
    ERICH MACKOW; Fiscal Year: 2003

Detail Information

Publications272 found, 100 shown here

  1. ncbi Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis
    Monique Clement
    INSERM U601, Institut de Biologie, 9 quai Moncousu, 44093 Nantes Cedex, France
    J Cell Sci 117:5059-69. 2004
    ....
  2. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
    In their roles as major adhesion receptors, integrins signal across the plasma membrane in both directions...
  3. ncbi Integrins in cancer: biological implications and therapeutic opportunities
    Jay S Desgrosellier
    Department of Pathology, Moores University of California at San Diego Cancer Center, La Jolla, 92093 0803, United States
    Nat Rev Cancer 10:9-22. 2010
    ..The importance of integrins in several cell types that affect tumour progression has made them an appealing target for cancer therapy...
  4. ncbi Integrins: masters and slaves of endocytic transport
    Patrick T Caswell
    Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, G61 3BX, Scotland
    Nat Rev Mol Cell Biol 10:843-53. 2009
    ..in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis ..
  5. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
    ..focal and fibrillar adhesions characterized on 2D substrates in their content of alpha5beta1 and alphavbeta3 integrins, paxillin, other cytoskeletal components, and tyrosine phosphorylation of focal adhesion kinase (FAK)...
  6. ncbi Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
    ....
  7. ncbi HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    James Arthos
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:301-9. 2008
    ..On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1...
  8. ncbi Integrin signaling
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 285:1028-32. 1999
    ..The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals ..
  9. ncbi Integrins
    Malgorzata Barczyk
    Department of Biomedicine, University of Bergen, Norway
    Cell Tissue Res 339:269-80. 2010
    b>Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes...
  10. ncbi Adhesion signaling - crosstalk between integrins, Src and Rho
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Cell Sci 122:1059-69. 2009
    ..b>Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly...
  11. ncbi Vinculin controls focal adhesion formation by direct interactions with talin and actin
    Jonathan D Humphries
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester M13 9PT, England, UK
    J Cell Biol 179:1043-57. 2007
    ..The vinculin tail, however, is responsible for the functional link of FAs to the actin cytoskeleton. We propose a new model that explains how vinculin orchestrates FAs...
  12. ncbi Imaging of integrins as biomarkers for tumor angiogenesis
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, California, USA
    Curr Pharm Des 14:2943-73. 2008
    ..The design, optimization, and characterization of imaging agents targeting integrins will be presented and areas needing extensive future research effort will be discussed...
  13. ncbi Integrins: the keys to unlocking angiogenesis
    Rita Silva
    Adhesion and Angiogenesis Group, Centre for Tumour Biology, Cancer Research UK Clinical Centre, Institute of Cancer, Barts and The London and Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London UK
    Arterioscler Thromb Vasc Biol 28:1703-13. 2008
    ..b>Integrins are cell adhesion molecules that are expressed on the surface of endothelial cells and pericytes, making them ..
  14. ncbi Cell-matrix adhesion
    Allison L Berrier
    Katrina Visiting Faculty Program, National Center on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland, USA
    J Cell Physiol 213:565-73. 2007
    ..Many of these interactions involve transmembrane integrin receptors. Integrins cluster in specific cell-matrix adhesions to provide dynamic links between extracellular and intracellular ..
  15. ncbi The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
    Nicholas J Anthis
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    EMBO J 28:3623-32. 2009
    Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that uniquely mediate inside-out signal transduction, whereby adhesion to the extracellular matrix is activated from within the cell by ..
  16. ncbi The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission
    Fatima Nawaz
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 7:e1001301. 2011
    ..Understanding the structural features that characterize early-transmitting gp120s may aid in the design of an effective gp120-based subunit vaccine...
  17. ncbi The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
    Claudia Cicala
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:20877-82. 2009
    ..The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission...
  18. ncbi Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    M Tamura
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Science 280:1614-7. 1998
    ..Overexpression of FAK partially antagonized the effects of PTEN. Thus, PTEN phosphatase may function as a tumor suppressor by negatively regulating cell interactions with the extracellular matrix...
  19. ncbi The final steps of integrin activation: the end game
    Sanford J Shattil
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Mol Cell Biol 11:288-300. 2010
    Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby contributing to embryonic development and diseases such ..
  20. ncbi Integrins: roles in cancer development and as treatment targets
    H Jin
    John and Rebecca Moores Comprehensive Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0912, USA
    Br J Cancer 90:561-5. 2004
    ..Several integrins play key roles in promoting tumour angiogenesis and tumour metastasis...
  21. ncbi The interplay between Src and integrins in normal and tumor biology
    Martin P Playford
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Oncogene 23:7928-46. 2004
    ....
  22. ncbi Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility
    Lindsay Gillan
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Res 62:5358-64. 2002
    ..Furthermore, alpha(V)beta(3) integrin, but not beta(1) integrins, colocalizes to the focal adhesion plaques formed on PN...
  23. ncbi Integrin ligands at a glance
    Jonathan D Humphries
    Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 119:3901-3. 2006
  24. ncbi Integrins and cell-fate determination
    Charles H Streuli
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 122:171-7. 2009
    All cellular processes are determined by adhesive interactions between cells and their local microenvironment. Integrins, which constitute one class of cell-adhesion receptor, are multifunctional proteins that link cells to the ..
  25. ncbi Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1
    X Z Huang
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, San Francisco, California 94143 0854, USA
    Mol Cell Biol 20:5208-15. 2000
    ..Our results suggest that the alpha9 integrin is required for the normal development of the lymphatic system, including the thoracic duct, and that alpha9 deficiency could be one cause of congenital chylothorax...
  26. ncbi FAK integrates growth-factor and integrin signals to promote cell migration
    D J Sieg
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Cell Biol 2:249-56. 2000
    ..Our results establish that FAK is an important receptor-proximal link between growth-factor-receptor and integrin signalling pathways...
  27. ncbi Structural basis for ligand recognition by integrins
    Junichi Takagi
    Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Opin Cell Biol 19:557-64. 2007
    b>Integrins, the major cell surface receptors mediating cell-extracellular matrix (ECM) adhesion, are central to the basic physiology underlying all multicellular organisms...
  28. ncbi Integrins in angiogenesis and lymphangiogenesis
    Christie J Avraamides
    Moores UCSD Cancer Center, 3, 855 Health Sciences Drive, La Jolla, California 92092 0819, USA
    Nat Rev Cancer 8:604-17. 2008
    ..Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a family of cell surface receptors whose ligands are extracellular matrix proteins and ..
  29. ncbi Integrins and anoikis
    S M Frisch
    Burnham Institute, La Jolla Cancer Research Center, CA 92037, USA
    Curr Opin Cell Biol 9:701-6. 1997
    ..Focal adhesion kinase, when activated by integrins, can suppress anoikis...
  30. ncbi Signal co-operation between integrins and other receptor systems
    Charles H Streuli
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, U K
    Biochem J 418:491-506. 2009
    ..In the present review we explore how one class of adhesion receptor, the integrins, co-operate with other types of receptor to control diverse aspects of cell fate...
  31. ncbi Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
    Motomu Shimaoka
    The Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 112:99-111. 2003
    ..Pulling down on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in affinity...
  32. ncbi Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): role of heparan sulfate, DC-SIGN, integrins and signaling
    Nagaraj Kerur
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Virology 406:103-16. 2010
    ..In addition to the previously identified integrins alpha3beta1, alphavbeta3 and alphavbeta5, integrin alpha5beta1 was also utilized for infection...
  33. ncbi The integrins
    Yoshikazu Takada
    Department of Dermatology, University of California Davis School of Medicine, Second Avenue, Sacramento, CA 95817, USA
    Genome Biol 8:215. 2007
    The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands...
  34. ncbi Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain
    Adam L Feire
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:15470-5. 2004
    ..entry, HCMV induces cellular morphological changes and signaling cascades consistent with engagement of cellular integrins; however, HCMV structural proteins do not possess the widely used RGD integrin-binding motif...
  35. ncbi Integrins and extracellular matrix in mechanotransduction
    Martin Alexander Schwartz
    Departments of Microbiology, Cell Biology, and Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Cold Spring Harb Perspect Biol 2:a005066. 2010
    b>Integrins bind extracellular matrix fibrils and associate with intracellular actin filaments through a variety of cytoskeletal linker proteins to mechanically connect intracellular and extracellular structures...
  36. ncbi Requirement of vascular integrin alpha v beta 3 for angiogenesis
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 264:569-71. 1994
    ..These findings suggest that alpha v beta 3 may be a useful therapeutic target for diseases characterized by neovascularization...
  37. ncbi Role of integrins in cell invasion and migration
    John D Hood
    Scripps Research Institute, Departments of Immunology and Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Cancer 2:91-100. 2002
    ..The attachment is mediated by cell-surface receptors known as integrins, which bind to components of the extracellular matrix...
  38. ncbi The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1
    Jeffrey C Nolz
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Biol 182:1231-44. 2008
    ..These findings identify a previously unknown mechanism by which the WAVE2 complex regulates TCR signaling to Rap1 and integrin activation...
  39. ncbi Signalling via integrins: implications for cell survival and anticancer strategies
    Stephanie Hehlgans
    OncoRay, Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74 PF 86, 01307 Dresden, Germany
    Biochim Biophys Acta 1775:163-80. 2007
    ..b>Integrins are heterodimeric cell-surface molecules that on one side link the actin cytoskeleton to the cell membrane and ..
  40. ncbi Outside-in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation?
    Eliane J Muller
    Molecular Dermatology, Institute of Animal Pathology and DermFocus, Vetsuisse Faculty, University of Bern, Bern, Switzerland
    J Invest Dermatol 128:501-16. 2008
    ..Recent insights into adhesion receptor signaling now propose that integrins, but also cadherins, can centrally control these programs...
  41. ncbi Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
    J O Lee
    Laboratory of X ray Crystallography, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115
    Cell 80:631-8. 1995
    ..We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain...
  42. ncbi Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts
    K P McHugh
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 105:433-40. 2000
    ..Thus, although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteoclast function...
  43. ncbi The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment
    Triantafyllos Chavakis
    Department of Internal Medicine I, University Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    J Exp Med 198:1507-15. 2003
    ..of RAGE with the beta2-integrin Mac-1 and, to a lower extent, with p150,95 but not with LFA-1 or with beta1-integrins. The RAGE-Mac-1 interaction was augmented by the proinflammatory RAGE-ligand, S100-protein...
  44. ncbi Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion
    H Gardner
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
    Dev Biol 175:301-13. 1996
    ..Further in vitro analysis of cell spreading and migration suggests that alpha 1 beta 1 is not required for binding to collagen I and implicates a third receptor, possibly integrin alpha 3 beta 1, in collagen I binding...
  45. ncbi Integrin traffic
    Teijo Pellinen
    VTT Medical Biotechnology, FIN-20520 Turku, Finland
    J Cell Sci 119:3723-31. 2006
    ..migration and the maintenance of cell polarity are all processes that depend on the correct targeting of integrins and the dynamic remodelling of integrin-containing adhesion sites...
  46. ncbi The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing
    Yung-Feng Liao
    Center for Engineering in Medicine and Surgical Service, Massachusetts General Hospital and Harvard Medical School, the Shriners Burns Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 277:14467-74. 2002
    ..Nonetheless, integrins that bind the EIIIA segment have not been identified...
  47. ncbi Integrin-dependent actomyosin contraction regulates epithelial cell scattering
    Johan de Rooij
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 171:153-64. 2005
    ..is enhanced on collagen and fibronectin, as compared with laminin1, suggesting possible cross talk between integrins and cell-cell junctions...
  48. ncbi Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions
    Francesco J Conti
    The Scripps Research Institute, Department of Cell Biology and Institute of Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    Development 136:3597-606. 2009
    Talin 1 and 2 connect integrins to the actin cytoskeleton and regulate the affinity of integrins for ligands...
  49. ncbi Integrins as therapeutic targets: lessons and opportunities
    Dermot Cox
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Nat Rev Drug Discov 9:804-20. 2010
    The integrins are a large family of cell adhesion molecules that are essential for the regulation of cell growth and function...
  50. ncbi Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton
    Shizhen Emily Wang
    Division of Tumor Cell Biology, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    Cancer Res 69:475-82. 2009
    ..transforming growth factor beta (TGF-beta) induced focal adhesion kinase (FAK)-dependent clustering of HER2 and integrins alpha(6), beta(1), and beta(4) in HER2-overexpressing mammary epithelial cells without altering the total and ..
  51. ncbi Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours
    F A L M Eskens
    Erasmus Medical Center, Department of Medical Oncology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Cancer 39:917-26. 2003
    A single-agent dose escalating phase I and pharmacokinetic study with Cilengitide, an inhibitor of the integrins alphavbeta3 and alphavbeta5, was performed to determine its safety and toxicity...
  52. ncbi Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8
    Liudmila S Chesnokova
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 106:20464-9. 2009
    ..of cells expressing gB and gHgL can be blocked by vitronectin or triggered by addition of soluble truncated integrins alphavbeta6 and alphavbeta8...
  53. ncbi Structure and mechanics of integrin-based cell adhesion
    M Amin Arnaout
    Nephrology Division, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, United States
    Curr Opin Cell Biol 19:495-507. 2007
    b>Integrins are alpha/beta heterodimeric adhesion glycoprotein receptors that regulate a wide variety of dynamic cellular processes such as cell migration, phagocytosis, and growth and development...
  54. ncbi Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets
    Christopher S Stipp
    Departments of Biology and Molecular Physiology and Biophysics, 210 Iowa Avenue, BBE 236, University of Iowa, Iowa City, IA 52242, USA
    Expert Rev Mol Med 12:e3. 2010
    Within the integrin family of cell adhesion receptors, integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 make up a laminin-binding subfamily...
  55. ncbi Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain
    Aaron K Mobley
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Cell Sci 122:1842-51. 2009
    ..Collectively, these data identify essential functions for beta8 integrin in regulating neurovascular unit physiology in the post-natal mouse brain...
  56. ncbi Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 186:1044-59. 2011
    ....
  57. ncbi Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells
    Yannick D Benoit
    CIHR Team on Digestive Epithelium, Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Biochem Biophys Res Commun 399:434-9. 2010
    ..is expressed in human intestinal epithelial crypt cells (HIECs) and represents one of the major RGD-binding integrins expressed by these cells...
  58. ncbi Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells
    Heather M Bill
    Van Andel Research Institute, 333 Bostwick Ave, SE, Grand Rapids, MI 49503, USA
    Mol Cell Biol 24:8586-99. 2004
    ..The ability of integrins to induce the activation of EGFR and its subsequent regulation of Erk and Akt activation permitted adhesion-..
  59. ncbi Quantitative proteomics identifies a Dab2/integrin module regulating cell migration
    Anjali Teckchandani
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 186:99-111. 2009
    ..Surface levels of integrins beta1, alpha1, alpha2, and alpha3 but not alpha5 or alphav chains were specifically increased on Dab2-deficient ..
  60. ncbi Integrins in cell adhesion and signaling
    S K Akiyama
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Hum Cell 9:181-6. 1996
    ..The best characterized cell adhesion receptors are the integrins. Integrins comprise a family of more than 23 noncovalent, heterodimeric complexes consisting of an alpha and a ..
  61. ncbi Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development
    Arjan van der Flier
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 137:2439-49. 2010
    ..Here, we report on the roles of the alpha5 and alphav integrins, which are the major endothelial fibronectin receptors, in developmental angiogenesis...
  62. ncbi Integrins as a distinct subtype of dependence receptors
    D G Stupack
    Department of Pathology, UCSD School of Medicine and Moore s UCSD Comprehensive Cancer Center 3855 Health Sciences Drive MC 0803 La Jolla, CA 92093 0803, USA
    Cell Death Differ 12:1021-30. 2005
    ..The integrins are a family of heterodimeric receptors for extracellular matrix (ECM) proteins, mediating cell anchorage and ..
  63. ncbi Kindlins in FERM adhesion
    Nikolay L Malinin
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, OH 44195, USA
    Blood 115:4011-7. 2010
    ..This review discusses recent progress in the studies of Kindlin protein family, emphasizing newly identified functions and potential mechanisms underlying differential activities of the family members...
  64. ncbi Molecular basis of the recognition of nephronectin by integrin alpha8beta1
    Yuya Sato
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 284:14524-36. 2009
    ....
  65. ncbi Vascular integrins: therapeutic and imaging targets of tumor angiogenesis
    Curzio Ruegg
    Division of Experimental Oncology, Centre Pluridisciplinaire d Oncologie, 155, Chemin des Boveresses, CH1066, Epalinges, Switzerland
    Recent Results Cancer Res 180:83-101. 2010
    ..In preclinical studies, pharmacological inhibition of vascular integrins suppressed angiogenesis and inhibited tumor progression...
  66. ncbi Lymph node stromal cells support dendritic cell-induced gut-homing of T cells
    Rosalie Molenaar
    Department of Molecular Cell Biology and Immunology, VU Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 183:6395-402. 2009
    ..Therefore, cooperation of sessile lymph node stromal cells with mobile dendritic cells warrants the imprinting of tissue specific homing receptors on activated T cells...
  67. ncbi Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression
    Michael Stefanidakis
    Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland
    Blood 108:1441-50. 2006
    Leukocyte motility is known to be dependent on both beta2-integrins and matrix metalloproteinases MMP-2/-9 or gelatinases, which mediate leukocyte adhesion and the proteolysis needed for invasion, respectively...
  68. ncbi Fibronectin- and vitronectin-induced microglial activation and matrix metalloproteinase-9 expression is mediated by integrins alpha5beta1 and alphavbeta5
    Richard Milner
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 20550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 178:8158-67. 2007
    ..showed that the influence of fibronectin and vitronectin was mediated by the alpha(5)beta(1) and alpha(v)beta(5) integrins, respectively...
  69. ncbi Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix
    Pierre Jean Wipff
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Cell Biol 179:1311-23. 2007
    ..This process is inhibited either by antagonizing integrins or reducing ECM compliance and is independent from protease activity...
  70. ncbi Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development
    Kelly Beumer
    Department of Biology, University of Utah, Salt Lake City, UT 84112 0840, USA
    Development 129:3381-91. 2002
    ..We show that PS integrins function upstream of CaMKII in the development of synaptic architecture at the NMJ...
  71. ncbi Focal adhesion kinase modulates cell adhesion strengthening via integrin activation
    Kristin E Michael
    Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Mol Biol Cell 20:2508-19. 2009
    ..This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-ECM forces...
  72. ncbi Forces for morphogenesis investigated with laser microsurgery and quantitative modeling
    M Shane Hutson
    Department of Physics and Free Electron Laser Laboratory, Duke University, Durham, NC 27708, USA
    Science 300:145-9. 2003
    ....
  73. ncbi Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control
    S Lindemann
    Eccles Program in Human Biology and Genetics and the Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Biol Chem 276:33947-51. 2001
    ..Additional studies demonstrated that beta(3) integrins are the primary membrane receptor that distributes eIF4E within the cell...
  74. ncbi Vitronectin and its receptors
    B Felding Habermann
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037
    Curr Opin Cell Biol 5:864-8. 1993
    ..is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha IIb beta 3...
  75. ncbi Extracellular matrix and integrin signalling: the shape of things to come
    N J Boudreau
    Surgical Research Laboratory, University of California, San Francisco, CA 94143, USA
    Biochem J 339:481-8. 1999
    The extracellular matrix (ECM) and integrins collaborate to regulate gene expression associated with cell growth, differentiation and survival...
  76. ncbi Getting to the site of inflammation: the leukocyte adhesion cascade updated
    Klaus Ley
    Robert M Berne Cardiovascular Research Center and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 7:678-89. 2007
    ..This Review focuses on new aspects of one of the central paradigms of inflammation and immunity--the leukocyte adhesion cascade...
  77. ncbi Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer
    G Gasparini
    Division of Medical Oncology, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
    Clin Cancer Res 4:2625-34. 1998
    ....
  78. ncbi The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
    J S Munger
    Department of Medicine, and Kaplan Cancer Center, New York University School of Medicine, New York 10016 6402, USA
    Cell 96:319-28. 1999
    ..These data identify a novel mechanism for locally regulating TGF beta 1 function in vivo by regulating expression of the alpha v beta 6 integrin...
  79. ncbi A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors
    Yiwen Jan
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 116:751-62. 2004
    ..Thus, we have elucidated an integrin-controlled pathway that is, at least in part, responsible for the cell survival effects of cell-ECM interactions...
  80. ncbi Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells
    Ralph Knoll
    Institute of Molecular Medicine, University of California at San Diego, La Jolla, Calif, USA
    Circulation 116:515-25. 2007
    ..Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly understood...
  81. ncbi MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice
    Krishna Kumar Veeravalli
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
    PLoS ONE 5:e11583. 2010
    ..present study, MMP-9, uPAR and cathepsin B genes were downregulated in glioma xenograft cells using shRNA plasmid constructs and we evaluated the involvement of integrins and changes in their adhesion, migration and invasive potential.
  82. ncbi Integrins and proximal signaling mechanisms in cardiovascular disease
    Hind Lal
    Division of Molecular Cardiology, Cardiovascular Research Institute, The Texas AandM University System Health Science Center, College of Medicine, Baylor College of Dentistry, The Texas A and M Health Science Center, Dallas, TX, USA
    Front Biosci 14:2307-34. 2009
    b>Integrins are heterodimeric cell-surface molecules, which act as the principle mediators of molecular dialog between a cell and its extracellular matrix environment...
  83. ncbi Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis
    Sam M Janes
    Keratinocyte Laboratory, CR-UK London Research Institute, 44 Lincoln's Inn Fields, WC2A 3PX, England
    J Cell Biol 166:419-31. 2004
    ..of this finding, we transduced an alphav-negative human SCC line with retroviral vectors encoding alphav integrins. alphavbeta5-expressing cells underwent suspension-induced apoptosis (anoikis), whereas alphav-negative cells ..
  84. ncbi Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches
    Robert M Bellin
    Department of Biology, College of the Holy Cross, 1 College Street, Worcester, MA 01610, USA
    Proc Natl Acad Sci U S A 106:22102-7. 2009
    ..Of significant interest has been the contribution of the transmembrane proteins involved, and integrins in particular, because of their connectivity to both the extracellular matrix and the cytoskeleton...
  85. ncbi Integrins and coagulation: a role for ROS/redox signaling?
    David Gregg
    Division of Cardiology, University of California San Francisco, USA
    Antioxid Redox Signal 6:757-64. 2004
    ..Ligation of integrins in endothelial cells and platelets induces activation of the Ras/mitogen-activated protein kinase, nuclear ..
  86. ncbi A 2D-DIGE approach to identify proteins involved in inside-out control of integrins
    Jeroen D Langereis
    Department of Respiratory Medicine, University Medical Center, Utrecht, The Netherlands
    J Proteome Res 8:3824-33. 2009
    Leukocyte integrins are functionally regulated by "inside-out" signaling, meaning that stimulus-induced signaling pathways act on the intracellular integrin tail and induce activation of the receptor at the outside...
  87. ncbi Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins
    Dirk Schneider
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    J Biol Chem 279:9840-6. 2004
    The alpha and beta subunits of alpha/beta heterodimeric integrins function together to bind ligands in the extracellular region and transduce signals across cellular membranes...
  88. ncbi Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells
    Sophie Kusy
    IPBC, CNRS UMR 6187, Faculté des Sciences de Poitiers, 40 Avenue du Recteur Pineau, Poitiers 86022, France
    Neoplasia 7:457-65. 2005
    ..Thus, in this in vivo lung cancer model, SEMA3F has potent antitumor effects, which may impinge on activated integrin and MAPK signaling...
  89. ncbi Regulation of cell adhesion signaling by synthetic glycopolymer matrix in primary cultured hepatocyte
    Sang-Heon Kim
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, 226-8501 Yokohama, Japan
    FEBS Lett 553:433-9. 2003
    ..The data suggest that the glycopolymer will be a good artificial matrix to regulate integrin-mediated signaling and cell growth through the unique ASGPR-carbohydrate interaction...
  90. ncbi Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes
    Edith Hintermann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:8004-15. 2005
    Keratinocyte integrins alpha6beta4 and alpha3beta1 bind laminin-5, a component of basement membranes...
  91. ncbi Regulation of cell adhesion and migration in lens development
    Peggy S Zelenka
    Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892 0704, USA
    Int J Dev Biol 48:857-65. 2004
    ..This review will summarize those findings and relate them to relevant studies of the lens to provide an outline of the cellular events that lead to lens morphogenesis...
  92. ncbi Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1
    David P Choma
    Center for Cell Biology and Cancer Research, Albany Medical College, MC 165, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cell Sci 117:3947-59. 2004
    Epithelial cell migration is a crucial event in wound healing, yet little is known about mechanisms whereby integrins regulate epithelial cell polarization and migration...
  93. ncbi CNTO 95, a fully human monoclonal antibody that inhibits alphav integrins, has antitumor and antiangiogenic activity in vivo
    Mohit Trikha
    Centocor, Inc, Malvern, PA 19355, USA
    Int J Cancer 110:326-35. 2004
    b>Integrins of the alphav family, such as alphavbeta3 and alphavbeta5, are implicated in tumor-induced angiogenesis; but their role in tumor growth has not been fully explored...
  94. ncbi Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion
    D R Critchley
    Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK
    Biochem Soc Trans 32:831-6. 2004
    ..Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration...
  95. ncbi Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts
    Takaki Shima
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 100:14897-902. 2003
    ....
  96. ncbi Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits
    Sung Koo Kang
    Oriental Herbal Research Institute, Dongkuk University, Seoul 156 756, Republic of Korea
    J Biol Chem 279:36593-600. 2004
    ..G(h)/TG2 is coimmunoprecipitated by an integrin alpha(5) antibody and binds to the cytoplasmic tail peptide of integrins alpha(5), alpha(v), and alpha(IIb) subunits in the presence of guanosine 5'-3-O-(thio)triphosphate (GTPgammaS)...
  97. ncbi Deletion of mouse embryo fibroblast N-acetylglucosaminyltransferase V stimulates alpha5beta1 integrin expression mediated by the protein kinase C signaling pathway
    Hua Bei Guo
    Department of Biochemistry and Molecular Biology and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, USA
    J Biol Chem 280:8332-42. 2005
    ....
  98. ncbi Lamellipodia nucleation by filopodia depends on integrin occupancy and downstream Rac1 signaling
    Herve Guillou
    Universite Joseph Fourier, Grenoble, France
    Exp Cell Res 314:478-88. 2008
    ..Thereby, lamellipodia nucleation by filopodia requires integrin occupancy by matrix substrate and downstream Rac1 signaling...
  99. ncbi Differential regulation of the lateral mobility of plasma membrane phospholipids by the extracellular matrix and cholesterol
    O G Ramprasad
    Center for Cellular and Molecular Biology, Hyderabad, India
    J Cell Physiol 215:550-61. 2008
    ..molecules in the plasma membrane of intact cells under various conditions of specific interaction of integrins in the cell membrane with two extracellular matrix (ECM) components viz. fibronectin (FN) and laminin (LN)...
  100. ncbi The RGD integrin binding site in human L1-CAM is important for nuclear signaling
    Daniela Gast
    Tumor Immunology Programme, D010, German Cancer Research Center, Heidelberg, Germany
    Exp Cell Res 314:2411-8. 2008
    ..The RGD motif in the sixth Ig domain of L1 is a binding site for integrins. In the present study we analyzed the role of RGDs in L1-signaling using site-directed mutagenesis combined with ..
  101. ncbi Involvement of extracellular matrix and integrin-like proteins on conidial adhesion and appressorium differentiation in Magnaporthe oryzae
    Cheol Yong Bae
    Department of Agricultural Biotechnology, Center for Fungal Genetic Resources, Seoul National University, Seoul 151 921, Korea
    J Microbiol Biotechnol 17:1198-203. 2007
    ..These results suggest that extracellular matrix proteins might be involved in conidial adhesion and appressorium formation through integrin-like receptor mediation and modulation of cAMP-dependent signaling in the cells...

Research Grants88

  1. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 1999
    ..We propose, in this application, to examine a family of receptors for ECM proteins, the integrins, and the cell-matrix interactions in the human TM...
  2. BETA 1 INTEGRIN ANTAGONISM & RETINAL NEOVASCULARIZATION
    DONALD SENGER; Fiscal Year: 2001
    ..VEGF markedly induces expression of the alpha-1-beta-1, alpha-2-beta-1, and alpha- 5-beta-3 cell surface integrins in dermal microvascular endothelial cells (ECs), and antagonism of alpha-1-beta-1, alpha-2-beta-1, and alpha-5 ..
  3. Regulation of Integrins in Neovasculature Development
    Tatiana Byzova; Fiscal Year: 2009
    ..Angiogenesis is driven by Vascular Endothelial Growth Factor (VEGF) and cell adhesion receptors, integrins on endothelial and blood cells...
  4. Regulation of invadopodia formation in breast cancer cells
    Anthony J Koleske; Fiscal Year: 2010
    ..In turn, Arg phosphorylates cortactin to promote dynamic invadopodia-like cell edge protrusions. Integrins 1 and 3, and Arg are all upregulated in highly invasive breast cancer cells, and inhibiting Arg or cortactin ..
  5. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
    ..3) Assess the effect of the bicistronic Ad-uPAR-pl6 construct on the expression of integrins (particularly avlI3) and molecules involved in signaling pathways mediated by integrins...
  6. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D Milner; Fiscal Year: 2009
    ..tested by this proposal is that cerebral ischemia induces brain endothelial cell expression of the a51 and av3 integrins, and that fibronectin promotes cerebral angiogenesis, via these integrins...
  7. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D RICHARD MILNER; Fiscal Year: 2010
    ..tested by this proposal is that cerebral ischemia induces brain endothelial cell expression of the a51 and av3 integrins, and that fibronectin promotes cerebral angiogenesis, via these integrins...
  8. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2010
    ..Analysis of FAK Activity Binding interactions between extracellular matrix proteins such as fibronectin and integrins play fundamental roles during development by controlling cell adhesion, motility, and survival...
  9. Molecular Basis of ILK/PINCH Function in Cell Adhesion
    Jun Qin; Fiscal Year: 2010
    ..This interaction (cell adhesion) is mediated primarily by integrins, a group of heterodimeric transmembrane receptors that bind to ECM proteins via their extracellular domains...
  10. HANTAVIRUS CELL INTERACTIONS
    ERICH MACKOW; Fiscal Year: 2003
    ..We have recently determined that alphanubeta3 and alphaIIbbeta3 integrins are cellular receptors for pathogenic, but not non-pathogenic, hantaviruses and this finding directly relates ..
  11. Brain tumor angiogenesis: Integrin ceramide signaling
    Anat Erdreich Epstein; Fiscal Year: 2007
    ..Our goal in this proposal is to examine ceramide as a molecular target in inhibition of endothelial integrins alphavbeta3/beta5...
  12. MOLECULAR ASPECTS OF CORNEAL EPITHELIAL MIGRATION
    MARY STEPP; Fiscal Year: 1992
    ..A family of integral membrane, cell- surface glycoproteins called integrins (formerly termed "fibronectin receptors", vitro-nectin receptors) function in mediating migration of cells ..
  13. Regulation of Vascular Tone and Ca channels by Integrins
    Michael Davis; Fiscal Year: 2009
    Interactions between vascular integrins and extracellular matrix (ECM) components of the blood vessel wall are important determinants of arteriolar tone and blood flow control...
  14. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy Macklin; Fiscal Year: 2009
    ..We hypothesize that PLP interacts with integrins and neurotransmitter receptors, and thereby modulates a series of events in developing brain as well as in the ..
  15. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy B Macklin; Fiscal Year: 2010
    ..We hypothesize that PLP interacts with integrins and neurotransmitter receptors, and thereby modulates a series of events in developing brain as well as in the ..
  16. Integrin Signaling in Nervous System Development
    Louis Reichardt; Fiscal Year: 2005
    ..Work over the past decade has shown that integrins mediate many of these interactions...
  17. Endothelial Cell Adhesion and Function on Smooth Muscle
    George A Truskey; Fiscal Year: 2010
    ..b>Integrins play an important role in endothelial force transduction...
  18. Functional Roles of Integrins in Modulating Neural Responses of Mechanically Sens
    Michael Hadjiargyrou; Fiscal Year: 2007
    ..The current proposal seeks to investigate the functional roles that trans-membrane proteins, integrins, play in modulating neural responses of cutaneous mechanoreceptors...
  19. Endothelial Cell Adhesion and Function on Smooth Muscle
    GEORGE TRUSKEY; Fiscal Year: 2009
    ..b>Integrins play an important role in endothelial force transduction...
  20. INTEGRIN SIGNALING PATHWAYS IN PROSTATE CANCER
    Lucia R Languino; Fiscal Year: 2010
    b>Integrins comprise a large family of cell surface receptors with critical roles in cancer cell proliferation, invasion and metastatic potential...
  21. Activation of alpha5beta3 integrin on blood and endothelial cells
    Tatiana Byzova; Fiscal Year: 2007
    The family of cell surface molecules, the integrins, mediates multiple physiological and pathological responses, including inflammation, atherosclerosis and cancer development, thrombus formation and angiogenesis...
  22. INTEGRIN REGULATION AND FUNCTIONS IN ADULT BRAIN
    Christine Gall; Fiscal Year: 2007
    ..Research in this program has shown that integrins are concentrated at synapses and influence neurotrophin expression, and glutamate receptor and ion channel ..
  23. Beta2 Integrin Activation and Signaling
    Vineet Gupta; Fiscal Year: 2007
    The leukocyte specific beta2 integrins are central to the biological function of these cells...
  24. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2010
    DESCRIPTION: Integrins are a broad family of cell surface adhesion and signaling molecules which link the extracellular matrix (ECM) to the cytoskeleton of the cell...
  25. Regulation of dendritic spine shape and synapse and dendrite stability by Arg
    Anthony J Koleske; Fiscal Year: 2010
    ..We seek to understand how integrins signal through Arg and its effectors to control the formation and maintenance of neural circuitry...