fc receptors

Summary

Summary: Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.

Top Publications

  1. ncbi Albumin binding to FcRn: distinct from the FcRn-IgG interaction
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:4983-90. 2006
  2. ncbi Fcgamma receptors as regulators of immune responses
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054 Erlangen, Germany
    Nat Rev Immunol 8:34-47. 2008
  3. pmc Involvement of Fc receptors in disorders of the central nervous system
    Eitan Okun
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuromolecular Med 12:164-78. 2010
  4. pmc Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis
    Ekaterina Maidji
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, San Francisco, San Francisco, CA 94143 0512, USA
    Am J Pathol 168:1210-26. 2006
  5. ncbi Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    Masaru Yoshida
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunity 20:769-83. 2004
  6. ncbi Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89
    R J Pleass
    Department of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    J Biol Chem 274:23508-14. 1999
  7. ncbi Fc receptors and their role in immune regulation and autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology and CREST Program of Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Clin Immunol 25:1-18. 2005
  8. ncbi IgA Fc receptors
    Renato C Monteiro
    1INSERM E0225, Bichat Medical School, 16 rue Henri Huchard, Paris 75870, France
    Annu Rev Immunol 21:177-204. 2003
  9. pmc Role of IgA and IgA fc receptors in inflammation
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:1-9. 2010
  10. ncbi Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Nature 344:742-6. 1990

Detail Information

Publications271 found, 100 shown here

  1. ncbi Albumin binding to FcRn: distinct from the FcRn-IgG interaction
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:4983-90. 2006
    ..Our results suggest that the FcRn-albumin interaction has unique features distinct from FcRn-IgG binding despite the overall similarity in the pH-dependent binding mechanism by which both ligands are protected from degradation...
  2. ncbi Fcgamma receptors as regulators of immune responses
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054 Erlangen, Germany
    Nat Rev Immunol 8:34-47. 2008
    In addition to their role in binding antigen, antibodies can regulate immune responses through interacting with Fc receptors (FcRs)...
  3. pmc Involvement of Fc receptors in disorders of the central nervous system
    Eitan Okun
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuromolecular Med 12:164-78. 2010
    ..Knowledge of the functions of FcRs in the nervous system in health and disease is leading to novel preventative and therapeutic strategies for stroke, Alzheimer's disease, and other neurological disorders...
  4. pmc Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis
    Ekaterina Maidji
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, San Francisco, San Francisco, CA 94143 0512, USA
    Am J Pathol 168:1210-26. 2006
    ..These findings could explain the efficacy of hyperimmune IgG for treatment of primary CMV infection during gestation and support vaccination...
  5. ncbi Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    Masaru Yoshida
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunity 20:769-83. 2004
    ..These results explain how IgG is secreted onto mucosal surfaces and scavenges luminal antigens for recognition by the immune system...
  6. ncbi Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89
    R J Pleass
    Department of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    J Biol Chem 274:23508-14. 1999
    ..We have thus identified motifs in the interdomain region of IgA Fc critical for FcalphaR binding and triggering, significantly enhancing present understanding of the molecular basis of the IgA-FcalphaR interaction...
  7. ncbi Fc receptors and their role in immune regulation and autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology and CREST Program of Japan Science and Technology Agency, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Clin Immunol 25:1-18. 2005
    The activation threshold of cells in the immune system is often tuned by cell surface molecules. The Fc receptors expressed on various hematopoietic cells constitute critical elements for activating or downmodulating immune responses and ..
  8. ncbi IgA Fc receptors
    Renato C Monteiro
    1INSERM E0225, Bichat Medical School, 16 rue Henri Huchard, Paris 75870, France
    Annu Rev Immunol 21:177-204. 2003
    ..Finally, recent work points out a role for human IgA in treatment of infectious and neoplastic diseases...
  9. pmc Role of IgA and IgA fc receptors in inflammation
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:1-9. 2010
    ..However, IgA can also, when aggregated, be deleterious to the host, inducing inflammatory diseases. This Janus-like nature of IgA is mainly due to their heterogeneity in molecular forms and their interaction with IgA receptors...
  10. ncbi Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Nature 344:742-6. 1990
    ....
  11. pmc Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008
    ....
  12. pmc Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung
    Gerburg M Spiekermann
    The Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Boston, MA 02115, USA
    J Exp Med 196:303-10. 2002
    ..These data show that mucosal surfaces that express FcRn reabsorb IgG and explain a mechanism by which IgG may act in immune surveillance to retrieve lumenal antigens for processing in the lamina propria or systemically...
  13. pmc Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008
    Numerous studies have demonstrated that targeting Ag to Fc receptors (FcR) on APCs can enhance humoral and cellular immunity...
  14. ncbi Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)
    A P West
    Division of Biology 156 29 and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 39:9698-708. 2000
    ..The structure of human FcRn and studies of its ligand binding are relevant to current efforts to use FcRn-mediated regulation of IgG half-life in serum to increase the lifetimes of antibody-based therapeutics...
  15. ncbi FcRn: the neonatal Fc receptor comes of age
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:715-25. 2007
    ..This Review summarizes these two areas of FcRn biology...
  16. pmc Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice
    Konstantia Maria Chavele
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 120:1469-78. 2010
    ..We suggest that targeting MR may provide an alternative therapeutic approach in CGN while minimizing the impact on adaptive immune responses, which are affected by conventional immunosuppressive approaches...
  17. ncbi A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection
    T Yoneto
    Department of Allergology and Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 166:6236-41. 2001
    ..These results suggest that FcR-mediated Ab-dependent phagocytosis, which is located downstream of IFN-gamma production, is important as an effector mechanism to eliminate PRBC in blood-stage P. berghei XAT infection...
  18. ncbi Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors
    John C Martyn
    The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Vic, Australia
    Arch Virol 154:1129-38. 2009
    ..to recombinant soluble FcgammaRIIalpha receptor and to cell lines and antigen-presenting cells expressing Fc receptors (FcRs)...
  19. ncbi Mast cell-derived cytokine expression induced via Fc receptors and Toll-like receptors
    Yoshimichi Okayama
    Laboratory for Allergy Transcriptome, RIKEN Research Center for Allergy and Immunology, Yokohama City, Kanagawa, Japan
    Chem Immunol Allergy 87:101-10. 2005
    ..The results indicated that human MCs might modulate the immune system in a receptor-specific manner by releasing cytokines in quantitatively and qualitatively different ways...
  20. ncbi Fc receptors as determinants of allergic reactions
    Stefan Kraft
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Trends Immunol 27:88-95. 2006
    ..in the positive and negative regulation of Fc receptor expression and signaling have shed light on the role of Fc receptors in our immune system, indicating them to be bifunctional, inhibitory and activating structures...
  21. pmc Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals
    R C Monteiro
    Department of Pediatrics, University of Alabama at Birmingham
    J Clin Invest 92:1681-5. 1993
    ..The data indicate that expression of Fc alpha R molecules with a characteristic glycosylation pattern is upregulated on eosinophils in allergic individuals...
  22. ncbi Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding
    W L Martin
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell 7:867-77. 2001
    ..The structure reveals conformational changes in Fc and three titratable salt bridges that confer pH-dependent binding, and can be used to guide rational design of therapeutic IgGs with longer serum half-lives...
  23. ncbi Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4+ T lymphocytes
    Thijs van Montfort
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, Meibergdreef 15, Amsterdam, The Netherlands
    J Immunol 178:3177-85. 2007
    ..The increased capture of the 2F5-neutralized virus by iMDDCs was negated upon blocking the Fc receptors. Blocking DC-SIGN on iMDDCs resulted in a 70-75% inhibition of HIV-1 capture at 37 degrees C, whereas at 4 ..
  24. ncbi Immature neutrophils mediate tumor cell killing via IgA but not IgG Fc receptors
    Marielle A Otten
    Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, The Netherlands
    J Immunol 174:5472-80. 2005
    ..This may provide a rationale for the disappointing results observed in some earlier clinical trials in which patients were treated with G-CSF and antitumor Ab-targeting FcgammaR...
  25. ncbi A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
    L Borges
    Immunex Corp, Seattle, WA 98101, USA
    J Immunol 159:5192-6. 1997
    ..Like killer inhibitory receptors, at least two LIRs bind to MHC class I Ags, but their different cellular distribution suggests a distinct role in immune system modulation...
  26. ncbi Immunoglobulin transport across polarized epithelial cells
    Raul Rojas
    Laboratory of Epithelial Cell Biology, Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Nat Rev Mol Cell Biol 3:944-55. 2002
    ..Recent studies on the intracellular transport pathways of antibody-receptor complexes and antibody-stimulated receptor-mediated transcytosis are providing new insight into the nature and regulation of endocytic pathways...
  27. ncbi Fc receptors and immunity to parasites
    R J Pleass
    Dept of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, DD1 9SY, Dundee, UK
    Trends Parasitol 17:545-51. 2001
    b>Fc receptors (FcRs) are crucial in the immune system; they mediate a plethora of biological functions as diverse as antigen presentation, phagocytosis, cytotoxicity, induction of inflammatory cascades and modulation of immune responses...
  28. ncbi Phagocytosis and clearance of apoptotic cells is mediated by MER
    R S Scott
    UNC Neuroscience Center, USA
    Nature 411:207-11. 2001
    ..Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus...
  29. pmc Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn
    E J Israel
    Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    Immunology 89:573-8. 1996
    ..These data suggest that FcRn can protect IgG from degradation, and is therefore important in maintaining IgG levels in the circulation...
  30. ncbi Roles of Fc receptors in autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology, Japan Science and Technology Corporation, Institute of Development, Ageing and Cancer, Tohoku University, Seiryo, Sendai, Japan
    Nat Rev Immunol 2:580-92. 2002
  31. ncbi Fc receptor but not complement binding is important in antibody protection against HIV
    Ann J Hessell
    Department of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 449:101-4. 2007
    ..Overall, the data suggest the potential importance of activity against both infected cells and free virus for effective protection against HIV...
  32. ncbi Complement, Fc receptors and antibodies: a Trojan horse in HIV infection?
    Heribert Stoiber
    Section of Hygiene and Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Curr Opin HIV AIDS 4:394-9. 2009
    ..Thus, immediately upon entering the host, independent on the route of infection, HIV activates the complement system. Although a first line of immune defense, complement cannot eliminate retroviral infections completely...
  33. ncbi Tryptophan- and dileucine-based endocytosis signals in the neonatal Fc receptor
    Z Wu
    Rosenstiel Center for Basic Biomedical Sciences, W. M. Keck Institute for Cellular Visualization, Brandeis University, Waltham, MA 02254-9110, USA
    J Biol Chem 276:5240-7. 2001
    ..This shift appeared to arise because the loss of endocytosis signals inhibited apical to basolateral transcytosis of FcRn more than basolateral to apical transcytosis...
  34. ncbi Decoding IgE Fc receptors
    Ming Zhang
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Res 37:1-16. 2007
    ..A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively...
  35. ncbi Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells
    J C Leung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam
    J Am Soc Nephrol 11:241-9. 2000
    ..The present study concluded that there was an absence of Fc alphaR1, ASGPR, or pIgR on human mesangial cells. These findings suggest that the predominant binding of human IgA to human mesangial cells is mediated by other mechanisms...
  36. ncbi The Fc receptor gamma-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin
    Oscar Berlanga
    Department of Pharmacology, University of Oxford, UK
    Eur J Biochem 269:2951-60. 2002
    ..These results demonstrate that reconstitution of the GPVI-FcR gamma-chain complex in cells expressing the necessary signalling network is sufficient to initiate signalling events in response to convulxin and collagen-related peptide...
  37. ncbi Critical role for complement receptor 3 (CD11b/CD18), but not for Fc receptors, in killing of Streptococcus pyogenes by neutrophils in human immune serum
    Maria Nilsson
    Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden
    Eur J Immunol 35:1472-81. 2005
    ..Surprisingly, blocking of the Fc receptors had little effect on the killing...
  38. ncbi Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells
    Gøril Berntzen
    Department of Molecular Biosciences, University of Oslo, P O Box 1041, 0316, Oslo, Norway
    J Immunol Methods 298:93-104. 2005
    ..The approach should be of interest to laboratories that do not have access to a bioreactor but still have a requirement for reasonable amounts of protein to be produced in an easy and cost-effective manner...
  39. ncbi Differential regulation of myelin phagocytosis by macrophages/microglia, involvement of target myelin, Fc receptors and activation by intravenous immunoglobulins
    Tanja Kuhlmann
    Department of Neuropathology, Charite, Humboldt Universitat, Berlin, Germany
    J Neurosci Res 67:185-90. 2002
    ..phagocytosis of PNS myelin by peripheral macrophages was associated with an increased expression of macrophage Fc receptors measured by FACS...
  40. pmc Antigen binding to secretory immunoglobulin A results in decreased sensitivity to intestinal proteases and increased binding to cellular Fc receptors
    Mélanie Duc
    Department of Immunology and Allergy, University State Hospital CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    J Biol Chem 285:953-60. 2010
    ..This identifies immune complexes as particular structural entities integrating the presence of bound antigens and adds to the known function of immune exclusion and mucus anchoring by SIgA...
  41. ncbi Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn
    Raimund J Ober
    Cancer Immunobiology Center and Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 172:2021-9. 2004
    ..The studies provide a dynamic view of the trafficking of FcRn and its ligand and have relevance to understanding how FcRn functions to maintain IgG homeostasis...
  42. ncbi Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc
    Andrew B Herr
    Division of Biology 114 96, California Institute of Technology, Pasadena, California 91125, USA
    Nature 423:614-20. 2003
    ....
  43. ncbi Fc receptors: role in biology and antibody therapy
    Jan G J van de Winkel
    Department of Immunology, University Medical Center Utrecht, and Genmab, P O Box 85199, 3508 AD Utrecht The Netherlands
    Immunol Lett 128:4-5. 2010
    ..b>Fc receptors have been found to be crucial for normal immunity and to play an important role in the mechanisms of action of ..
  44. pmc Antibody-based HIV-1 vaccines: recent developments and future directions
    David Montefiori
    Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Med 4:e348. 2007
  45. ncbi Transmembrane domains in the functions of Fc receptors
    Raphael Zidovetzki
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Biophys Chem 100:555-75. 2003
    ....
  46. ncbi Differential B cell expression of mouse Fc receptor homologs
    Randall S Davis
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, 35294 3300, USA
    Int Immunol 16:1343-53. 2004
    ..The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells...
  47. ncbi Fc receptors
    J V Ravetch
    DeWitt Wallace Research Laboratories, Sloan Kettering Institute for Cancer Research, New York, New York 10021
    Annu Rev Immunol 9:457-92. 1991
    ..The detailed analysis of the IgG and IgE Fc receptors has indicated that these molecules have evolved from a common precursor through gene duplication...
  48. ncbi Fc receptors as potential targets for the treatment of allergy, autoimmune disease and cancer
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 3:187-97. 2003
    ..On the contrary, activating-type Fc receptors are crucial for the onset and exacerbation of such diseases...
  49. pmc A synthetic mimic of human Fc receptors: defined chemical modification of cell surfaces enables efficient endocytic uptake of human immunoglobulin-G
    Siwarutt Boonyarattanakalin
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Am Chem Soc 128:11463-70. 2006
    ..Certain human leukocytes and epithelial cells express Fc receptors (FcRs) that bind and internalize antibodies through this mechanism...
  50. pmc A full complement of receptors in immune complex diseases
    Jeffrey V Ravetch
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, New York 10021, USA
    J Clin Invest 110:1759-61. 2002
  51. ncbi Human anti-idiotypic antibodies can be good immunogens as they target FC receptors on antigen-presenting cells allowing efficient stimulation of both helper and cytotoxic T-cell responses
    L G Durrant
    CRC Academic Unit of Clinical Oncology, University of Nottingham, City Hospital, Nottingham, United Kingdom
    Int J Cancer 92:414-20. 2001
    ..Human anti-idiotypes are therefore good immunogens since they target Fc receptors on antigen-presenting cells, allowing efficient stimulation of both helper and cytotoxic T-cell responses...
  52. pmc Dependence of antibody-mediated presentation of antigen on FcRn
    Shuo Wang Qiao
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:9337-42. 2008
    ....
  53. ncbi Polyclonal immunoglobulins (IVIg) modulate nitric oxide production and microglial functions in vitro via Fc receptors
    M Stangel
    Department of Neurology, Universitatsklinikum Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Neuroimmunol 112:63-71. 2001
    ..inhibition of Syk and phosphatidylinositol 3-kinase, two enzymes involved in the signalling cascade of Fc receptors. TNFalpha secretion was dose-dependently stimulated by IVIg in both untreated microglia and after stimulation ..
  54. pmc Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors
    Stephen L Sazinsky
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:20167-72. 2008
    ....
  55. ncbi Channel catfish NK-like cells are armed with IgM via a putative FcmicroR
    Linling Shen
    Department of Microbiology, University of Mississippi, Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Dev Comp Immunol 27:699-714. 2003
    ..This is the first report suggesting that teleost NK-like cells express a putative FcmicroR which participates in antibody-dependent cell-mediated cytotoxicity...
  56. ncbi Cross-talk between Fc receptors and integrins
    Alejandro Ortiz-Stern
    Department of Immunology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Apartado Postal 70228, Ciudad Universitaria, Mexico D F, C P 04510, Mexico
    Immunol Lett 90:137-43. 2003
    b>Fc receptors (FcRs) and integrins are both key players of immune responses. These receptors are capable of independent signaling that leads to various cell functions...
  57. pmc IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution
    T S Ramalingam
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 21:590-601. 2002
    ....
  58. ncbi Fc receptor biology
    M Daeron
    Laboratoire d Immunologie Cellulaire et Clinique, INSERM U 255, Institut Curie, Paris, France
    Annu Rev Immunol 15:203-34. 1997
    This review deals with membrane Fc receptors (FcR) of the immunoglobulin superfamily. It is focused on the mechanisms by which FcR trigger and regulate biological responses of cells on which they are expressed...
  59. ncbi Antibodies, Fc receptors and cancer
    Falk Nimmerjahn
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Opin Immunol 19:239-45. 2007
    ..These novel insights into antibody FcR interactions might be useful to produce the next generation of improved immunotherapeutic molecules...
  60. ncbi The role of IgA and IgA Fc receptors as anti-inflammatory agents
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:S61-4. 2010
    ....
  61. pmc Microglial Fc receptors mediate physiological changes resulting from antibody cross-linking of myelin oligodendrocyte glycoprotein
    Cecilia B Marta
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, United States
    J Neuroimmunol 196:35-40. 2008
    ..Here, we show that similar events occur when anti-MOG is cross-linked with Fc receptors (FcRs) present on microglia but not with complement...
  62. ncbi Human NK cells express Fc receptors for IgA which mediate signal transduction and target cell killing
    Gabriela Mota
    Center of Immunology, Institute of Virology, Bucharest, Romania
    Eur J Immunol 33:2197-205. 2003
    ..In this work the expression of Fc receptors for IgA (FcalphaR) on human NK cells and the signaling events were investigated...
  63. pmc Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity
    Falk Nimmerjahn
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:8433-7. 2007
    ..which is a prerequisite for antibody-mediated effector functions, such as the interaction with cellular Fc receptors or the complement component C1q...
  64. pmc Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level
    Raimund J Ober
    Center for Immunology, University of Texas Southwestern Medical Center, and Department of Electrical Engineering, University of Texas at Dallas, USA
    Proc Natl Acad Sci U S A 101:11076-81. 2004
    ..Such retrograde movement may represent a mechanism for FcRn retrieval. Our studies provide insight into the events that lead to IgG exocytosis...
  65. ncbi Human antibody-Fc receptor interactions illuminated by crystal structures
    Jenny M Woof
    Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
    Nat Rev Immunol 4:89-99. 2004
    ..classes trigger different effector mechanisms through interaction of immunoglobulin Fc regions with specific Fc receptors (FcRs) on immune cells...
  66. ncbi Crystal structure of the complex of rat neonatal Fc receptor with Fc
    W P Burmeister
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125
    Nature 372:379-83. 1994
    ..4) and suggesting an unusual orientation of FcRn on the membrane...
  67. pmc Rhesus macaque polyclonal and monoclonal antibodies inhibit simian immunodeficiency virus in the presence of human or autologous rhesus effector cells
    Donald N Forthal
    Department of Medicine, Division of Infectious Diseases, School of Medicine, University of California Irvine, Irvine, CA 92697 4028, USA
    J Virol 80:9217-25. 2006
    ..Finally, our data underscore the potential importance of Fc-Fc receptor interactions in mediating biological activities of antibody...
  68. pmc Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells
    Gotz R A Ehrhardt
    Division of Clinical and Developmental Immunology, University of Alabama at Birmingham, Birmingham, Birmingham, AL 35294, USA
    J Exp Med 202:783-91. 2005
    ..Cell surface FcRH4 expression thus marks a unique population of memory B cells with distinctive morphology, functional capabilities, and tissue localization...
  69. ncbi An Fc receptor structurally related to MHC class I antigens
    N E Simister
    Whitehead Institute for Biomedical Research, Nine Cambridge, Massachusetts 02142
    Nature 337:184-7. 1989
    ..b>Fc receptors on intestinal epithelial cells of the neonatal rat (FcRn) mediate the uptake of IgG from milk...
  70. ncbi Fc receptors: rubor redux
    J V Ravetch
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 78:553-60. 1994
  71. ncbi The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans
    M Firan
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Immunol 13:993-1002. 2001
    ..FcRn therefore plays a central role in the maternofetal delivery of IgG and this has implications for the use of protein engineering to improve the properties of therapeutic antibodies...
  72. pmc MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells
    X Zhu
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:3266-76. 2001
    ....
  73. pmc Identification of a family of Fc receptor homologs with preferential B cell expression
    R S Davis
    Divisions of Hematology Oncology, Department of Medicine, University of Alabama, Birmingham 35294 3300, USA
    Proc Natl Acad Sci U S A 98:9772-7. 2001
    ....
  74. ncbi Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway
    Jennifer A Dumont
    Syntonix Pharmaceuticals, Inc, Waltham, Massachusetts 02451, USA
    J Aerosol Med 18:294-303. 2005
    ....
  75. ncbi An extended family of Fc receptor relatives
    Randall S Davis
    Division of Developmental and Clinical Immunology, University of Alabama, Birmingham, USA
    Eur J Immunol 35:674-80. 2005
    ..Their ligands, function, and prospective roles as diagnostic B cell markers and therapeutic targets are topics of intense interest...
  76. ncbi Human placental Fc receptors and the trapping of immune complexes
    N E Simister
    Rosenstiel Center for Basic Biomedical Sciences, W M Keck Institute for Cellular Visualization, Brandeis University, Waltham, MA 02254 9110, USA
    Vaccine 16:1451-5. 1998
    ..The receptors responsible for trapping immune complexes appear to be Fc gamma RIa, Fc gamma RIIa, and Fc gamma RIIIa on stromal macrophages, and Fc gamma RII on fetal capillary endothelial cells...
  77. ncbi Divergent roles for Fc receptors and complement in vivo
    J V Ravetch
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10021, USA
    Annu Rev Immunol 16:421-32. 1998
    ..These results necessitate a fundamental revision of the role of these antibody-binding systems in the immune response...
  78. ncbi IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells
    Ira Miller
    Institute of Cancer Genetics and the Department of Pathology, Columbia University, New York, NY 10032, USA
    Blood 99:2662-9. 2002
    ..All IRTA genes code for transmembrane receptors that are closely related to Fc receptors in their most amino-terminal extracellular domains and that possess cytoplasmic domains containing ITIM (..
  79. ncbi IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor
    Rashid Deane
    Division of Neurovascular Biology, Department of Neurosurgery, Arthur Kornberg Medical Research Building, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 25:11495-503. 2005
    ..Our data suggest that the FcRn pathway at the BBB plays a crucial role in IgG-assisted Abeta removal from the aging brain...
  80. pmc Neutrophils interact with adenovirus vectors via Fc receptors and complement receptor 1
    Matthew J Cotter
    Department of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Virol 79:14622-31. 2005
    ..These results demonstrate opsonin-dependent adenovirus vector interactions with neutrophils and their corresponding receptors...
  81. pmc Fc receptors are required in passive and active immunity to melanoma
    R Clynes
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY, USA
    Proc Natl Acad Sci U S A 95:652-6. 1998
    ....
  82. ncbi Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on adipocytes
    Jenny Palming
    Department of Metabolism and Cardiovascular Research, Institute of Medicine, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Biochem Biophys Res Commun 343:43-8. 2006
    ..05), but did not influence lipolysis. In conclusion, immunoglobulins produced by plasma cells in human adipose tissue could influence adipocyte metabolism and cytokine production...
  83. pmc Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
    Masaru Yoshida
    Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 116:2142-2151. 2006
    ....
  84. ncbi Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung
    Masahiro Sakagami
    Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, 23298 0533, USA
    Pharm Res 23:270-9. 2006
    ..FcRn expression in the upper tracheobronchial airways of the lung is recognized. In this study, we sought to characterize the functional expression of FcRn within alveolar regions of lung tissue...
  85. ncbi Species-specific evolution of the FcR family in endothermic vertebrates
    Svetlana A Fayngerts
    Laboratory of Immunogenetics, Institute of Cytology and Genetics, Novosibirsk, Russia
    Immunogenetics 59:493-506. 2007
    ....
  86. ncbi Regulation of antibody responses via antibodies, complement, and Fc receptors
    B Heyman
    Department of Genetics and Pathology, Uppsala University, Sweden
    Annu Rev Immunol 18:709-37. 2000
    ..IgG can enhance primary antibody responses in the absence of the complement system and seems to be dependent on Fc receptors for IgG (FcgammaRs). IgE enhances antibody responses via the low-affinity receptor for IgE (FcepsilonRII/CD23)...
  87. pmc Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors
    Meili Zhang
    Metabolism Branch, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 108:705-10. 2006
    ..We demonstrated that the expression of FcRgamma on polymorphonuclear leukocytes and monocytes was not required for HeFi-1-mediated tumor growth inhibition in vivo, although it was required for daclizumab...
  88. ncbi Fc receptors are major mediators of antibody based inflammation in autoimmunity
    P Mark Hogarth
    Helen McPherson Smith Laboratory, Austin Research Institute, Heidelberg, Vic, Australia
    Curr Opin Immunol 14:798-802. 2002
    ..Of increasing interest are Fc receptors, which have been more closely investigated in the past decade using recombinant proteins, gene deficient mice ..
  89. pmc Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin
    Steven M Claypool
    Harvard Medical School, Program in Immunology, Gastroenterogy Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 277:28038-50. 2002
    ..These results show that human FcRn travels to the cell surface via the normal secretory pathway and that the appropriate expression and function of human FcRn in MDCK cells depends upon the co-expression of human beta(2)m...
  90. ncbi In vivo veritas: the surprising roles of Fc receptors in immunity
    Jeffrey Ravetch
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, New York, USA
    Nat Immunol 11:183-5. 2010
    Jeffrey Ravetch describes how he came to identify the in vivo function of the once mysterious Fc receptors.
  91. ncbi A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1
    Sergei V Guselnikov
    Laboratory of Immunogenetics, Institute of Cytology and Genetics, Lavrentjev St 10, Novosibirsk 630090, Russia
    Immunogenetics 54:87-95. 2002
    A group of genes encoding proteins structurally related to the leukocyte Fc receptors (FcRs) and termed the IFGP family was identified in human and mouse...
  92. ncbi Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo
    Jiri Trcka
    The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center and Weill Graduate School of Cornell University, New York, NY 10021, USA
    Immunity 16:861-8. 2002
    ..Thus, either complement or macrophages expressing activating Fc gamma R can independently and alternatively mediate disease in a model of autoimmune vitiligo...
  93. pmc How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis
    Shuo Wang Qiao
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunology 120:145-7. 2007
  94. ncbi The impact of Fc receptors on the development of autoimmune diseases
    S Kleinau
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Curr Pharm Des 9:1861-70. 2003
    ..of autoantibodies to self-antigens, which initiate an inflammatory response through binding to immunoglobulin Fc receptors (FcRs) or via complement components...
  95. ncbi Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity
    Michaela Robbie-Ryan
    Graduate Program in Immunology and Molecular Pathogenesis, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 170:1630-4. 2003
    ..Notably, mice reconstituted with FcgammaRIII(-/-) BMMC exhibit a relapsing-remitting course of disease. These data demonstrate that both activating and inhibitory FcRs expressed on mast cells influence the course of EAE...
  96. ncbi Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family
    Randall S Davis
    Division of Hematology Oncology, University of Alabama at Birmingham, AL 35294, USA
    Immunol Rev 190:123-36. 2002
    Newfound relatives of the classical Fc receptors (FcR) have been provisionally named the Fc receptor homologs (FcRH)...
  97. ncbi Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells
    Randall S Davis
    Division of Hematology Oncology, University of Alabama, Bimingham 35294, USA
    Int Immunol 14:1075-83. 2002
    ..FcRX transcripts are found primarily in secondary lymphoid tissues, where they are expressed by B lineage cells. FcRX thus may function as a secreted or intracellular protein in normal and neoplastic B cells...
  98. pmc FcRn-mediated antibody transport across epithelial cells revealed by electron tomography
    Wanzhong He
    Division of Biology 114 96, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 455:542-6. 2008
    ..Markers for early, late and recycling endosomes each labelled vesicles in different and overlapping morphological classes, revealing spatial complexity in endo-lysosomal trafficking...
  99. ncbi Bivalent binding of IgA1 to FcalphaRI suggests a mechanism for cytokine activation of IgA phagocytosis
    Andrew B Herr
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Mol Biol 327:645-57. 2003
    ..The bivalent, pH-dependent interaction between FcalphaRI and IgA has important implications for cytokine-dependent phagocytosis of IgA and the FcalphaRI-mediated degradation or recycling of IgA...
  100. ncbi Cytotoxic antibodies trigger inflammation through Fc receptors
    R Clynes
    Program in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Immunity 3:21-6. 1995
    ..Roles have been proposed for Fc receptors, complement, and complement receptors in the pathogenesis of these disorders, although the contribution of each ..
  101. ncbi Neonatal Fc receptors discriminates and monitors the pathway of native and modified immunoglobulin G in placental endothelial cells
    Luminita Radulescu
    Institute of Cellular Biology and Pathology Nicolae Simionescu, 8, B P Hasdeu Street, Bucharest, 79691, Romania
    Hum Immunol 65:578-85. 2004
    ..We questioned the role of neonatal Fc receptors (FcRn) in the traffic of IgG in human placental endothelial cells (HPEC)...

Research Grants70

  1. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ....
  2. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..major hypotheses regarding the actions of A( immunotherapy are the facilitation of microglial phagocytosis via Fc receptors and promotion of A( removal from the brain by increasing the brain/blood concentration gradient via anti-A( ..
  3. Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?
    Bryce Binstadt; Fiscal Year: 2012
    ..Arthritis in this mouse model depends primarily on complement C5 and not Fc receptors;conversely, endocarditis depends essentially on Fc receptors and not C5...
  4. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2013
    ..levels of natural IgM and IgG antibodies specific for RTL that would likely bind to and signal through Fc receptors (FcR) when complexed with injected RTL, and it is possible that this pathway involves inhibitory FcR such as Fc?..
  5. Regulation of TSLP receptor expression and function in eczema in mice and man
    Steven F Ziegler; Fiscal Year: 2013
    ..depends upon the capacity for dendritic cells (DCs) to upregulate TSLP receptor (TSLPR) following ligation of Fc receptors by allergen...
  6. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2013
    ..Because there is a dearth of clinical trials for APS, an increased understanding of the role of the immune system in causing APS may form the basis for a rational clinical trial in this disease. ..
  7. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
    ..Our studies will increase the understanding of the molecular basis of sex bias in lupus disease and could potentially lead to better diagnostic tools as well as disease monitoring, and effective treatments. 1 ..
  8. Glucose energy metabolism in the growth and survival of B lymphocytes
    THOMAS CRANE CHILES; Fiscal Year: 2010
    ..abstract_text> ..
  9. CRP, eNOS and Endothelial Dysfunction
    Philip W Shaul; Fiscal Year: 2010
    ..The proposed research program will determine how CRP and its cell surface receptors cause hypertension and insulin resistance. ..
  10. Immune activation by cetuximab in head and neck cancer patients
    Robert L Ferris; Fiscal Year: 2013
    ..abstract_text> ..
  11. Key determinants of dengue virus neutralization by naturally occurring human mAbs
    Scott A Smith; Fiscal Year: 2013
    ..These skills, along with didactic coursework, will help me to develop my career, as a physician-scientist, in a direction independently of my mentor. ..
  12. Humanization of hFcRn Mice for Physiological Evaluation of Therapeutic Antibodies
    MICHAEL VAN WILES; Fiscal Year: 2013
    ..We fully expect these models to more accurately reflect human IgG and human albumin biology and, therefore, rapidly advance drug development and FcRn biology. ..
  13. Syk blockade in bullous skin diseases
    Uma Sinha; Fiscal Year: 2012
    ..In this Phase I program we will provide proof-of-concept for Syk inhibitors in BP using both animal models and relevant ex vivo human biospecimens. ..
  14. Defining the interaction of FCRLA with immunoglobulin
    PETER DANIEL BURROWS; Fiscal Year: 2013
    ..FCRLA is a resident ER protein that associates with immunoglobulin in this organelle. Unique among Fc receptors, FCRLA can associate with multiple isotypes of Ig, IgM, IgG and IgA...
  15. Protective immunity against HIV: the role of IgG subclass and glycosylation
    Donald Forthal; Fiscal Year: 2009
    Project Summary Engagement of IgG Fc receptors (Fc?Rs) on natural killer cells, monocytes, macrophages, or dendritic cells may play a critical role in preventing lentivirus infection...
  16. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2009
    ..Our long term goal is to define the interactions of the crucial pathways that contribute to induction and propagation of the anti-phospholipid syndrome so as to best devise individualized therapies for patients with SLE. ..
  17. Validating a novel biomarker of clinical progression and survival in CLL
    Randall S Davis; Fiscal Year: 2013
    ....
  18. ANTIGEN SPECIFIC T CELL TOLERANCE BY ANTI CD3 ANTIBODIES
    Claudio Anasetti; Fiscal Year: 2012
    ..Showing that non-FcR-binding anti-CD3 mAbs spare T cells specific for viral and tumor-associated antigens is key to predict patient safety. ..
  19. Estrogen Effects on Vascular Inflammation are Age and Hormone-Status Dependent
    Fadi Hage; Fiscal Year: 2013
    ..for the pro-inflammatory effect of CRP, which is mediated via its interaction with the immunoglobulin G Fc receptors (Fc?Rs) on monocytes/macrophages...
  20. Protective Human Monoclonal Antibodies to HIV-1
    SUSAN B ZOLLA-PAZNER; Fiscal Year: 2012
    ..These antibodies could also be used to develop products to treat HIV infection when used in conjunction with anti-retroviral drugs. ..
  21. Bifunctional antibodies with targeted CNS delivery against West Nile virus
    Qiang Chen; Fiscal Year: 2013
    ....
  22. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2013
    ....
  23. Development Structure and Function of Broadly Neutralizing anti-HIV Antibodies
    JEFFREY VICTOR RAVETCH; Fiscal Year: 2013
    ..functions by solving crystal structures of designed and natural bNAbs complexed with HIV Env proteins and Fc receptors;design and test immunogens for eliciting bNAbs...
  24. FcgRIIb protects fetus from allograft rejection
    Clark L Anderson; Fiscal Year: 2013
    ..What function, then, does RIIb serve? One possibility is that villus endothelial Fc receptors serve to trap and eliminate maternal IgG antibodies provoked by and directed toward foreign (paternal) antigen ..
  25. Fc gamma RIIB and Inflammation-Related Vascular Disease
    Philip W Shaul; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fc receptors (FcR) classically modulate responses to IgG in B cells and other effector cells in the immune system...
  26. Combination immunotherapy for neuroblastoma: model of innate tumor immunity
    Shakeel Modak; Fiscal Year: 2013
    ..Correlating donor-recipient KIR/HLA effects with outcome will clarify donor prioritization algorithms and provide prognostic value for future NK immunotherapy studies. ..
  27. Protective Effects of Anti-BclA Antibodies in Bacillus anthracis Infection
    JUAN B RODRIGUEZ BARRANTES; Fiscal Year: 2013
    ....
  28. Oxygen as a master immunologic switch
    Christopher A Pennell; Fiscal Year: 2013
    ..Collectively, this knowledge will facilitate groundbreaking approaches to enhance the efficacy of immunotherapy for glioma and other non-central nervous system tumors. ..
  29. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2011
    ..This application represents a multidisciplinary approach to build on a novel model for neuropsychiatric manifestations of lupus and a novel paradigm for antibody-mediated changes in cognition and behavior. ..
  30. The Role of Antibody-Mediated Protective Immunity Against Q fever
    Guoquan Zhang; Fiscal Year: 2010
    ..burnetii aerosol infection. ..
  31. CYTOKINE REGULATION OF RA SYNOVIOCYTE PHENOTYPE
    Lionel B Ivashkiv; Fiscal Year: 2013
    ..Fibrinogen activates signaling via [unreadable]2 integrins and immune complexes ligate Fc receptors. This finding was surprising, as [unreadable]2 integrins and Fc receptors signal via immunoreceptor tyrosine-..
  32. IgM Fc receptor in CLL
    Hiromi Kubagawa; Fiscal Year: 2013
    ..Evidence supporting the central hypothesis will greatly improve the understanding of the pathogenesis of CLL and justify the future exploration of the effectiveness of targeting Fc[unreadable]R in CLL. ..
  33. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..Project Description Page 6 ..
  34. Role of B-cells and CNS antibodies in modulating chronic microglial activation
    James R Lokensgard; Fiscal Year: 2013
    ..Based on these preliminary findings, it is likely that antibodies present within the CNS, operating through Fc receptors, and persisting Breg cells influence neuroimmune activation...
  35. Function of Phospholipase Cgamma2 in RANKL-Induced Osteoclastogenesis
    Yabing Chen; Fiscal Year: 2010
    ....
  36. An Advanced Model to Analyze CD4T Cel Reactions to Antibody and BCR V Regions
    Lawrence J Wysocki; Fiscal Year: 2012
    ..Neoantigenic Ab peptides may also activate CD4 T cells at sites of Ab deposition where APC gather Ab through Fc receptors or surface lectins...
  37. Role of autoantibody isotype in pemphigus pathogenesis
    Aimee S Payne; Fiscal Year: 2013
    ..In IgA pemphigus, neutrophilic skin abscesses are caused by anti-Dsg IgA binding to leukocyte Fc receptors, and anti-Dsg IgE may cause eosinophilic forms of pemphigus by analogy...
  38. Absorption of maternal antibodies from the gastrointestinal tract
    Lynn Puddington; Fiscal Year: 2012
    ..Our preliminary data challenge fundamental concepts in the basic understanding of the biology of FcRn, a molecular target with tremendous therapeutic potential to positively impact health in children and adults. ..
  39. Study of FcR Genes: Macrophages and Lymphocytes
    JEFFREY VICTOR RAVETCH; Fiscal Year: 2013
    ..These strains will be investigated for their ability to regulate FcgRIIB expression and for their interaction with other autoimmune susceptibility factors linked to human diseases. ..
  40. The Role of KIR and FcR Genotype in the Efficacy of mAb and IL2 Immunotherapy
    Paul M Sondel; Fiscal Year: 2013
    ....
  41. Role of Macrophage Activation in Carotid Plaque Instability
    Michelle R Lennartz; Fiscal Year: 2010
    ..Our data suggest that FcR signaling in involved in the development of unstable plaques. This research will determine the role of FcgR in plaque progression and rupture and provide novel targets for reducing heart attack and stroke. ..
  42. FASEB SRC on Immunoreceptors
    JENNIFER WOOF; Fiscal Year: 2012
    ..emphasis on antigen receptors, adhesion molecules, complement receptors, immunoglobulin family receptors and Fc receptors. This theme has enormous relevance for the biopharmaceutical industry because very many new drugs reaching the ..
  43. Chimeric IgG/A Tumor Immunotherapy
    KEITH WYCOFF; Fiscal Year: 2013
    ..Our collaborators at the University of Pennsylvania will evaluate the ability of these recombinant antibodies to shrink HER2-expressing syngeneic tumors in transgenic mice expressing both HER2/neu and human Fc?RI. ..
  44. Human immunoglobulin Fc receptor functions in sarcoidosis
    Jianming Wu; Fiscal Year: 2013
    ..the elevated immunoglobulins and immune complexes in the circulation and the altered expressions of IgG Fc receptors (Fc?Rs) on the immune cells are observed in sarcoidosis patients, suggesting that IgG immune complexes and ..
  45. Intestinal Immune Regulation by IgG and FcRn
    Richard S Blumberg; Fiscal Year: 2013
    ..In addition to identifying new therapeutic targets for the treatment of IBD and a host of other inflammatory diseases, this research will provide a firm basis upon which to extend the opportunities for FcRn-targeted therapies. ..
  46. Fcgamma mediated regulation of dendritic cell function
    Kavita Dhodapkar; Fiscal Year: 2012
    ....
  47. The Function of FcRn in Liver and the Role of N-Glycans
    Timothy T Kuo; Fiscal Year: 2010
    ....
  48. Immunobiology and Pathogenesis of Pulmonary Tularemia (Metzger, PD)
    Dennis W Metzger; Fiscal Year: 2013
    ..tularensis targeted to Fc receptors on lung antigen presenting cells or intranasal inoculation of an antioxidant mutant strain provides significant ..
  49. Study of FcR Genes: Macrophages and Lymphocytes
    JEFFREY VICTOR RAVETCH; Fiscal Year: 2012
    b>Fc receptors for IgG (Fc?R) are essential for mediating the effector properties of IgGs in vivo, as well as regulating the afferent response through the engagement of immune complexes with B cells and dendritic cells...
  50. Regulation of Persistent Ab Responses by Fc Receptors
    TIMOTHY L MANSER; Fiscal Year: 2010
    ..abstract_text> ..
  51. Zona Pellucida: Immunopathologic Study
    Kenneth S K Tung; Fiscal Year: 2013
    ..Our study will define many Treg functions relevant to many common human diseases such as: pemphigus vulgaris, IC disease (SLE), Sjogren's syndrome, APS1, gastritis, and male and female idiopathic infertility due to gonadal failure. ..
  52. Immunoglobulin as a novel ligand for HLA-DM
    Elizabeth D Mellins; Fiscal Year: 2012
    ..presenting cell types, such as macrophages and dendritic cells, that take up immune complexes via surface Fc receptors (FcR). These antigen/antibody complexes are also targeted to the endosomal pathway, where they encounter HLA-DM...
  53. Pathogenic Role of Islet Cell Autoantibodies in Type I Diabetes
    Raphael A Clynes; Fiscal Year: 2011
    ..abstract_text> ..
  54. Do peptide mimetics of gp41 improve antibody-epitope interactions?
    VINCENT JOSEPH VENDITTO; Fiscal Year: 2013
    ..The chemically modified peptides that induce neutralizing antibodies in rabbits could provide a widely applicable epitope design strategy for the development of vaccines to a variety of infectious diseases including HIV. ..
  55. FcRn-targeted mucosal HIV vaccine
    Xiaoping Zhu; Fiscal Year: 2013
    ....
  56. Mechanism-based Changes in Anti-METH Monoclonal Antibody Therapy During Pregnancy
    WILLIAM THOMAS ATCHLEY; Fiscal Year: 2013
    ....
  57. Innate Immunity: Elucidation and Modulation for Cancer Therapy
    Michael A Caligiuri; Fiscal Year: 2013
    ..The next 5 years of work will result in improved clinical outcome of cancer patients undergoing with mAb therapy. ..
  58. Therapeutic antibody to radiation inducible TIP1 activates immune effector cells
    Marshall Michener; Fiscal Year: 2012
    ..T cell response) based on opsonization of tumor cells by the anti-TIP-1 mAb and recognition of the Fc by Fc receptors on natural killer (NK) cells, dendritic cells (DC) and other cell types...
  59. Fc Receptor Signaling in Vaccine Design for the Elderly
    Biao Zheng; Fiscal Year: 2010
    ..b>Fc receptors (FcR) link the humoral and cellular branches of the immune system and have crucial functions in the activation ..
  60. Mechanistic studies of FcRn inhibitors for the treatment of IgG-mediated diseases
    ELIZABETH SALLY WARD; Fiscal Year: 2012
    ..We seek funds to carry out mechanistic and efficacy studies in mouse models that are a prerequisite to the use of these reagents to treat human disease. ..
  61. Immunomodulatory mechanism of volatile anesthetics
    Koichi Yuki; Fiscal Year: 2013
    ..Subsequently, our experimental results will provide insight into the underlying mechanism of volatile anesthetics-induced immunomodulation. ..
  62. Modeling FCRL6 regulation and function in transgenic mice
    Randall S Davis; Fiscal Year: 2013
    ..These studies will also facilitate the development of new targeted therapeutic interventions for modulating this interaction and effector lymphocyte function that are relevant to many human diseases. ..
  63. INTESTINAL & PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 2000
    ..Lastly, the proposed work almost completes the studies that follow directly from the discovery by the P.I. of MHC class I-related FcRs, and additional time will be essential to consider and plan future research directions. ..
  64. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2006
    ..Our preliminary studies have determined that Fc receptors for IgG are critical for antibody effectiveness, and that antibodies do not block bacterial adhesion or entry ..
  65. Recombinant Fc receptor therapeutics for systemic lupus erythematosus
    Periasamy Selvaraj; Fiscal Year: 2010
    ..affinity of Fc3Rs, which necessitates the administration of physiologically unattainable levels of recombinant Fc receptors. Furthermore, the high level of circulating IgG immediately will neutralize the action of high affinity ..
  66. IGA FC RECEPTORS
    JULIA PHILLIPS QUAGLIATA; Fiscal Year: 1993
    ..5) To establish whether the receptor plays a physiological role in the function of the cells...
  67. LIGAND BONDING FORCE AND CELL ADHESION BY CD16 ISOFORMS
    Cheng Zhu; Fiscal Year: 1999
    ..The proposed research will contribute to our understanding as to how the membrane anchor of Fc receptors affects their properties, their interactions with ligands, and the ability of such interactions to induce ..
  68. Ligand Binding Kinetics and Cell Adhesion by Fc Receptor
    Cheng Zhu; Fiscal Year: 2005
    ..It may also provide guidance to the development of Fc-gamma-R- based drugs for treatment of inflammatory disorders and auto-immune diseases. ..
  69. HUMAN NEUTROPHIL RC-RECEPTOR-MEDIATED PHAGOCYTOSIS
    Hattie Gresham; Fiscal Year: 1990
    ..mediators and intracellular enzymes in response to the binding of IgG containing immune complexes to PMN Fc receptors. The transmembrane signals that trigger ingestion of these complexes, lysosomal enzyme release, and/or ..
  70. Development of an anti-PSA IgE to treat prostate cancer
    Birgit Schultes; Fiscal Year: 2009
    ....