fc receptors

Summary

Summary: Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.

Top Publications

  1. ncbi Fcgamma receptors as regulators of immune responses
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054 Erlangen, Germany
    Nat Rev Immunol 8:34-47. 2008
  2. ncbi An Fc receptor structurally related to MHC class I antigens
    N E Simister
    Whitehead Institute for Biomedical Research, Nine Cambridge, Massachusetts 02142
    Nature 337:184-7. 1989
  3. ncbi Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008
  4. ncbi Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level
    Raimund J Ober
    Center for Immunology, University of Texas Southwestern Medical Center, and Department of Electrical Engineering, University of Texas at Dallas, USA
    Proc Natl Acad Sci U S A 101:11076-81. 2004
  5. ncbi Dependence of antibody-mediated presentation of antigen on FcRn
    Shuo Wang Qiao
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:9337-42. 2008
  6. ncbi Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008
  7. ncbi FcRn: the neonatal Fc receptor comes of age
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:715-25. 2007
  8. ncbi Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn
    Raimund J Ober
    Cancer Immunobiology Center and Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 172:2021-9. 2004
  9. ncbi Roles of Fc receptors in autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology, Japan Science and Technology Corporation, Institute of Development, Ageing and Cancer, Tohoku University, Seiryo, Sendai, Japan
    Nat Rev Immunol 2:580-92. 2002
  10. ncbi Immunoglobulin transport across polarized epithelial cells
    Raul Rojas
    Laboratory of Epithelial Cell Biology, Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Nat Rev Mol Cell Biol 3:944-55. 2002

Research Grants

  1. PHAGOCYTOSIS IN PULMONARY ALVEOLAR MACROPHAGES
    Steven Greenberg; Fiscal Year: 2000
  2. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
  3. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Walker; Fiscal Year: 1993
  4. Role of autoantibody isotype in pemphigus pathogenesis
    Aimee S Payne; Fiscal Year: 2010
  5. INTESTINAL AND PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 1999
  6. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
  7. Clinical Component
    Scott Plevy; Fiscal Year: 2003
  8. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2006
  9. PATHOPHYSIOLOGY OF CRYOGLOBULINEMIC GLOMERULONEPHRITIS
    CHARLES ALPERS; Fiscal Year: 2007
  10. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2006

Detail Information

Publications236 found, 100 shown here

  1. ncbi Fcgamma receptors as regulators of immune responses
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054 Erlangen, Germany
    Nat Rev Immunol 8:34-47. 2008
    In addition to their role in binding antigen, antibodies can regulate immune responses through interacting with Fc receptors (FcRs)...
  2. ncbi An Fc receptor structurally related to MHC class I antigens
    N E Simister
    Whitehead Institute for Biomedical Research, Nine Cambridge, Massachusetts 02142
    Nature 337:184-7. 1989
    ..b>Fc receptors on intestinal epithelial cells of the neonatal rat (FcRn) mediate the uptake of IgG from milk...
  3. ncbi Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008
    Numerous studies have demonstrated that targeting Ag to Fc receptors (FcR) on APCs can enhance humoral and cellular immunity...
  4. ncbi Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level
    Raimund J Ober
    Center for Immunology, University of Texas Southwestern Medical Center, and Department of Electrical Engineering, University of Texas at Dallas, USA
    Proc Natl Acad Sci U S A 101:11076-81. 2004
    ..Such retrograde movement may represent a mechanism for FcRn retrieval. Our studies provide insight into the events that lead to IgG exocytosis...
  5. ncbi Dependence of antibody-mediated presentation of antigen on FcRn
    Shuo Wang Qiao
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:9337-42. 2008
    ....
  6. ncbi Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008
    ....
  7. ncbi FcRn: the neonatal Fc receptor comes of age
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:715-25. 2007
    ..This Review summarizes these two areas of FcRn biology...
  8. ncbi Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn
    Raimund J Ober
    Cancer Immunobiology Center and Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 172:2021-9. 2004
    ..The studies provide a dynamic view of the trafficking of FcRn and its ligand and have relevance to understanding how FcRn functions to maintain IgG homeostasis...
  9. ncbi Roles of Fc receptors in autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology, Japan Science and Technology Corporation, Institute of Development, Ageing and Cancer, Tohoku University, Seiryo, Sendai, Japan
    Nat Rev Immunol 2:580-92. 2002
  10. ncbi Immunoglobulin transport across polarized epithelial cells
    Raul Rojas
    Laboratory of Epithelial Cell Biology, Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Nat Rev Mol Cell Biol 3:944-55. 2002
    ..Recent studies on the intracellular transport pathways of antibody-receptor complexes and antibody-stimulated receptor-mediated transcytosis are providing new insight into the nature and regulation of endocytic pathways...
  11. ncbi Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors
    John C Martyn
    The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Vic, Australia
    Arch Virol 154:1129-38. 2009
    ..to recombinant soluble FcgammaRIIalpha receptor and to cell lines and antigen-presenting cells expressing Fc receptors (FcRs)...
  12. ncbi Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding
    W L Martin
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell 7:867-77. 2001
    ..The structure reveals conformational changes in Fc and three titratable salt bridges that confer pH-dependent binding, and can be used to guide rational design of therapeutic IgGs with longer serum half-lives...
  13. ncbi Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)
    A P West
    Division of Biology 156 29 and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 39:9698-708. 2000
    ..The structure of human FcRn and studies of its ligand binding are relevant to current efforts to use FcRn-mediated regulation of IgG half-life in serum to increase the lifetimes of antibody-based therapeutics...
  14. ncbi Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn
    E J Israel
    Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    Immunology 89:573-8. 1996
    ..These data suggest that FcRn can protect IgG from degradation, and is therefore important in maintaining IgG levels in the circulation...
  15. ncbi Fc receptor but not complement binding is important in antibody protection against HIV
    Ann J Hessell
    Department of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 449:101-4. 2007
    ..Overall, the data suggest the potential importance of activity against both infected cells and free virus for effective protection against HIV...
  16. ncbi Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    Masaru Yoshida
    Gastroenterology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA
    Immunity 20:769-83. 2004
    ..These results explain how IgG is secreted onto mucosal surfaces and scavenges luminal antigens for recognition by the immune system...
  17. ncbi Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung
    Gerburg M Spiekermann
    The Combined Program in Pediatric Gastroenterology and Nutrition, Children's Hospital, Boston, MA 02115, USA
    J Exp Med 196:303-10. 2002
    ..These data show that mucosal surfaces that express FcRn reabsorb IgG and explain a mechanism by which IgG may act in immune surveillance to retrieve lumenal antigens for processing in the lamina propria or systemically...
  18. ncbi Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Nature 344:742-6. 1990
    ....
  19. ncbi Tryptophan- and dileucine-based endocytosis signals in the neonatal Fc receptor
    Z Wu
    Rosenstiel Center for Basic Biomedical Sciences, W. M. Keck Institute for Cellular Visualization, Brandeis University, Waltham, MA 02254-9110, USA
    J Biol Chem 276:5240-7. 2001
    ..This shift appeared to arise because the loss of endocytosis signals inhibited apical to basolateral transcytosis of FcRn more than basolateral to apical transcytosis...
  20. ncbi The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans
    M Firan
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Immunol 13:993-1002. 2001
    ..FcRn therefore plays a central role in the maternofetal delivery of IgG and this has implications for the use of protein engineering to improve the properties of therapeutic antibodies...
  21. ncbi MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells
    X Zhu
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:3266-76. 2001
    ....
  22. ncbi Albumin binding to FcRn: distinct from the FcRn-IgG interaction
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:4983-90. 2006
    ..Our results suggest that the FcRn-albumin interaction has unique features distinct from FcRn-IgG binding despite the overall similarity in the pH-dependent binding mechanism by which both ligands are protected from degradation...
  23. ncbi Decoding IgE Fc receptors
    Ming Zhang
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Res 37:1-16. 2007
    ..A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively...
  24. ncbi Cross-talk between Fc receptors and integrins
    Alejandro Ortiz-Stern
    Department of Immunology, , , Apartado Postal 70228, Ciudad Universitaria, , C.P. 04510, Mexico
    Immunol Lett 90:137-43. 2003
    b>Fc receptors (FcRs) and integrins are both key players of immune responses. These receptors are capable of independent signaling that leads to various cell functions...
  25. ncbi IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution
    T S Ramalingam
    Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 21:590-601. 2002
    ....
  26. ncbi Fc receptor biology
    M Daeron
    Laboratoire d Immunologie Cellulaire et Clinique, INSERM U 255, Institut Curie, Paris, France
    Annu Rev Immunol 15:203-34. 1997
    This review deals with membrane Fc receptors (FcR) of the immunoglobulin superfamily. It is focused on the mechanisms by which FcR trigger and regulate biological responses of cells on which they are expressed...
  27. ncbi Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung
    Masahiro Sakagami
    Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, 23298 0533, USA
    Pharm Res 23:270-9. 2006
    ..FcRn expression in the upper tracheobronchial airways of the lung is recognized. In this study, we sought to characterize the functional expression of FcRn within alveolar regions of lung tissue...
  28. ncbi Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells
    Gotz R A Ehrhardt
    Division of Clinical and Developmental Immunology, University of Alabama at Birmingham, Birmingham, Birmingham, AL 35294, USA
    J Exp Med 202:783-91. 2005
    ..Cell surface FcRH4 expression thus marks a unique population of memory B cells with distinctive morphology, functional capabilities, and tissue localization...
  29. ncbi Antibodies, Fc receptors and cancer
    Falk Nimmerjahn
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Opin Immunol 19:239-45. 2007
    ..These novel insights into antibody FcR interactions might be useful to produce the next generation of improved immunotherapeutic molecules...
  30. ncbi Channel catfish NK-like cells are armed with IgM via a putative FcmicroR
    Linling Shen
    Department of Microbiology, University of Mississippi, Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Dev Comp Immunol 27:699-714. 2003
    ..This is the first report suggesting that teleost NK-like cells express a putative FcmicroR which participates in antibody-dependent cell-mediated cytotoxicity...
  31. ncbi Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors
    Meili Zhang
    Metabolism Branch, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 108:705-10. 2006
    ..We demonstrated that the expression of FcRgamma on polymorphonuclear leukocytes and monocytes was not required for HeFi-1-mediated tumor growth inhibition in vivo, although it was required for daclizumab...
  32. ncbi Role of IgA and IgA fc receptors in inflammation
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:1-9. 2010
    ..However, IgA can also, when aggregated, be deleterious to the host, inducing inflammatory diseases. This Janus-like nature of IgA is mainly due to their heterogeneity in molecular forms and their interaction with IgA receptors...
  33. ncbi Microglial Fc receptors mediate physiological changes resulting from antibody cross-linking of myelin oligodendrocyte glycoprotein
    Cecilia B Marta
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, United States
    J Neuroimmunol 196:35-40. 2008
    ..Here, we show that similar events occur when anti-MOG is cross-linked with Fc receptors (FcRs) present on microglia but not with complement...
  34. ncbi Immature neutrophils mediate tumor cell killing via IgA but not IgG Fc receptors
    Marielle A Otten
    Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, The Netherlands
    J Immunol 174:5472-80. 2005
    ..This may provide a rationale for the disappointing results observed in some earlier clinical trials in which patients were treated with G-CSF and antitumor Ab-targeting FcgammaR...
  35. ncbi Phagocytosis and clearance of apoptotic cells is mediated by MER
    R S Scott
    UNC Neuroscience Center, USA
    Nature 411:207-11. 2001
    ..Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus...
  36. ncbi Involvement of Fc receptors in disorders of the central nervous system
    Eitan Okun
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuromolecular Med 12:164-78. 2010
    ..Knowledge of the functions of FcRs in the nervous system in health and disease is leading to novel preventative and therapeutic strategies for stroke, Alzheimer's disease, and other neurological disorders...
  37. ncbi Complement, Fc receptors and antibodies: a Trojan horse in HIV infection?
    Heribert Stoiber
    Section of Hygiene and Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Curr Opin HIV AIDS 4:394-9. 2009
    ..Thus, immediately upon entering the host, independent on the route of infection, HIV activates the complement system. Although a first line of immune defense, complement cannot eliminate retroviral infections completely...
  38. ncbi Human NK cells express Fc receptors for IgA which mediate signal transduction and target cell killing
    Gabriela Mota
    Center of Immunology, Institute of Virology, Bucharest, Romania
    Eur J Immunol 33:2197-205. 2003
    ..In this work the expression of Fc receptors for IgA (FcalphaR) on human NK cells and the signaling events were investigated...
  39. ncbi The role of IgA and IgA Fc receptors as anti-inflammatory agents
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:S61-4. 2010
    ....
  40. ncbi Fc receptors
    J V Ravetch
    DeWitt Wallace Research Laboratories, Sloan Kettering Institute for Cancer Research, New York, New York 10021
    Annu Rev Immunol 9:457-92. 1991
    ..The detailed analysis of the IgG and IgE Fc receptors has indicated that these molecules have evolved from a common precursor through gene duplication...
  41. ncbi Fc receptors: rubor redux
    J V Ravetch
    Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021
    Cell 78:553-60. 1994
  42. ncbi Regulation of antibody responses via antibodies, complement, and Fc receptors
    B Heyman
    Department of Genetics and Pathology, Uppsala University, Sweden
    Annu Rev Immunol 18:709-37. 2000
    ..IgG can enhance primary antibody responses in the absence of the complement system and seems to be dependent on Fc receptors for IgG (FcgammaRs). IgE enhances antibody responses via the low-affinity receptor for IgE (FcepsilonRII/CD23)...
  43. ncbi IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor
    Rashid Deane
    Division of Neurovascular Biology, Department of Neurosurgery, Arthur Kornberg Medical Research Building, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 25:11495-503. 2005
    ..Our data suggest that the FcRn pathway at the BBB plays a crucial role in IgG-assisted Abeta removal from the aging brain...
  44. ncbi IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy
    G Hatzivassiliou
    Institute of Cancer Genetics, Columbia University, New York, NY 10032, USA
    Immunity 14:277-89. 2001
    ..In tumor cell lines with 1q21 abnormalities, IRTA2 expression is deregulated. Thus, IRTA1 and IRTA2 are novel immunoreceptors implicated in B cell development and lymphomagenesis...
  45. ncbi Bivalent binding of IgA1 to FcalphaRI suggests a mechanism for cytokine activation of IgA phagocytosis
    Andrew B Herr
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Mol Biol 327:645-57. 2003
    ..The bivalent, pH-dependent interaction between FcalphaRI and IgA has important implications for cytokine-dependent phagocytosis of IgA and the FcalphaRI-mediated degradation or recycling of IgA...
  46. ncbi A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection
    T Yoneto
    Department of Allergology and Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 166:6236-41. 2001
    ..These results suggest that FcR-mediated Ab-dependent phagocytosis, which is located downstream of IFN-gamma production, is important as an effector mechanism to eliminate PRBC in blood-stage P. berghei XAT infection...
  47. ncbi Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells
    Gøril Berntzen
    Department of Molecular Biosciences, University of Oslo, P O Box 1041, 0316, Oslo, Norway
    J Immunol Methods 298:93-104. 2005
    ..The approach should be of interest to laboratories that do not have access to a bioreactor but still have a requirement for reasonable amounts of protein to be produced in an easy and cost-effective manner...
  48. ncbi Transmembrane domains in the functions of Fc receptors
    Raphael Zidovetzki
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Biophys Chem 100:555-75. 2003
    ....
  49. ncbi Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin
    Steven M Claypool
    Harvard Medical School, Program in Immunology, Gastroenterogy Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 277:28038-50. 2002
    ..These results show that human FcRn travels to the cell surface via the normal secretory pathway and that the appropriate expression and function of human FcRn in MDCK cells depends upon the co-expression of human beta(2)m...
  50. ncbi A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1
    Sergei V Guselnikov
    Laboratory of Immunogenetics, Institute of Cytology and Genetics, Lavrentjev St 10, Novosibirsk 630090, Russia
    Immunogenetics 54:87-95. 2002
    A group of genes encoding proteins structurally related to the leukocyte Fc receptors (FcRs) and termed the IFGP family was identified in human and mouse...
  51. ncbi Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity
    Michaela Robbie-Ryan
    Graduate Program in Immunology and Molecular Pathogenesis, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 170:1630-4. 2003
    ..Notably, mice reconstituted with FcgammaRIII(-/-) BMMC exhibit a relapsing-remitting course of disease. These data demonstrate that both activating and inhibitory FcRs expressed on mast cells influence the course of EAE...
  52. ncbi Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor
    Steven M Claypool
    Harvard Medical School, Program in Immunology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Mol Biol Cell 15:1746-59. 2004
    ..Thus, the strong cell surface polarity displayed by hFcRn results from dominant basolateral sorting by motifs in the cytoplasmic tail that nonetheless allows for a cycle of bidirectional transcytosis...
  53. ncbi Human antibody-Fc receptor interactions illuminated by crystal structures
    Jenny M Woof
    Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
    Nat Rev Immunol 4:89-99. 2004
    ..classes trigger different effector mechanisms through interaction of immunoglobulin Fc regions with specific Fc receptors (FcRs) on immune cells...
  54. ncbi Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo
    Jiri Trcka
    The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center and Weill Graduate School of Cornell University, New York, NY 10021, USA
    Immunity 16:861-8. 2002
    ..Thus, either complement or macrophages expressing activating Fc gamma R can independently and alternatively mediate disease in a model of autoimmune vitiligo...
  55. ncbi Neonatal Fc receptors discriminates and monitors the pathway of native and modified immunoglobulin G in placental endothelial cells
    Luminita Radulescu
    Institute of Cellular Biology and Pathology Nicolae Simionescu, 8, B. P. Hasdeu Street, Bucharest, 79691, Romania
    Hum Immunol 65:578-85. 2004
    ..We questioned the role of neonatal Fc receptors (FcRn) in the traffic of IgG in human placental endothelial cells (HPEC)...
  56. ncbi Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells
    Randall S Davis
    Division of Hematology Oncology, University of Alabama, Bimingham 35294, USA
    Int Immunol 14:1075-83. 2002
    ..FcRX transcripts are found primarily in secondary lymphoid tissues, where they are expressed by B lineage cells. FcRX thus may function as a secreted or intracellular protein in normal and neoplastic B cells...
  57. ncbi Channel catfish cytotoxic cells: a mini-review
    Linling Shen
    Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Dev Comp Immunol 26:141-9. 2002
    ..The availability of various cloned cytotoxic cell lines should enable unambiguous functional studies to be performed in ways not currently possible with any other fish species...
  58. ncbi Myosin vb is associated with plasma membrane recycling systems
    L A Lapierre
    Departments of Medicine, Surgery, and Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia 30912, USA
    Mol Biol Cell 12:1843-57. 2001
    ..The dominant negative effects of the myosin Vb tail chimera indicate that this unconventional myosin is required for transit out of plasma membrane recycling systems...
  59. ncbi Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family
    Randall S Davis
    Division of Hematology/Oncology, University of Alabama at Birmingham, AL 35294, USA
    Immunol Rev 190:123-36. 2002
    Newfound relatives of the classical Fc receptors (FcR) have been provisionally named the Fc receptor homologs (FcRH)...
  60. ncbi The impact of Fc receptors on the development of autoimmune diseases
    S Kleinau
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Curr Pharm Des 9:1861-70. 2003
    ..of autoantibodies to self-antigens, which initiate an inflammatory response through binding to immunoglobulin Fc receptors (FcRs) or via complement components...
  61. ncbi Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene
    Manzoor A Wani
    Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:5084-9. 2006
    ..This experiment of nature affirms our hypothesis that FcRn binds IgG and albumin, salvages both from a degradative fate, and maintains their physiologic concentrations...
  62. ncbi Effects of mutations in potential phosphorylation sites on transcytosis of FcRn
    K M McCarthy
    Rosenstiel Center for Basic Biomedical Sciences, W. M. Keck Institute for Cellular Visualization, and Biology Department, Brandeis University, Waltham, MA 02254-9110, USA
    J Cell Sci 114:1591-8. 2001
    ..FcRn-S313A recycled more Fc to the apical medium than the wild-type receptor, suggesting that Ser-313 is required to allow FcRn to be diverted from an apical recycling pathway to a transcytotic pathway...
  63. ncbi Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn
    C J Fitzer-Attas
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California 94143, USA
    J Exp Med 191:669-82. 2000
    ..Since FcgammaR-mediated phagocytosis did occur at modest levels in a delayed fashion in triple mutant macrophages, these Src family kinases are not absolutely required for uptake of IgG-opsonized particles...
  64. ncbi Crystal structure of the complex of rat neonatal Fc receptor with Fc
    W P Burmeister
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125
    Nature 372:379-83. 1994
    ..4) and suggesting an unusual orientation of FcRn on the membrane...
  65. ncbi A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
    L Borges
    Immunex Corp, Seattle, WA 98101, USA
    J Immunol 159:5192-6. 1997
    ..Like killer inhibitory receptors, at least two LIRs bind to MHC class I Ags, but their different cellular distribution suggests a distinct role in immune system modulation...
  66. ncbi Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus
    Qingshun Lin
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 177:1646-54. 2006
    Immune complex (IC)-mediated tissue inflammation is controlled by stimulatory and inhibitory IgG Fc receptors (FcgammaRs)...
  67. ncbi Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors
    Eric T Harvill
    Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802, USA
    Infect Immun 76:2177-82. 2008
    ..anthracis-challenged mice. Adoptively transferred sera were protective in mice lacking complement, Fc receptors, or both, suggesting that they operate independent of these effectors...
  68. ncbi How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis
    Shuo-Wang Qiao
    Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunology 120:145-7. 2007
  69. ncbi Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors
    Yoshikatsu Kaneko
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:789-97. 2006
    ..These results establish the significance of specific IgG subclasses and their cognate FcgammaRs in renal disease...
  70. ncbi Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor
    Devin B Tesar
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Traffic 7:1127-42. 2006
    ..We also demonstrate that hdFc and wtFc have different intracellular fates, with more hdFc than wtFc being trafficked to lysosomes and degraded, suggesting a role for avidity effects in FcRn-mediated IgG transport...
  71. ncbi Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89
    R J Pleass
    Department of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    J Biol Chem 274:23508-14. 1999
    ..We have thus identified motifs in the interdomain region of IgA Fc critical for FcalphaR binding and triggering, significantly enhancing present understanding of the molecular basis of the IgA-FcalphaR interaction...
  72. ncbi Antibody- and Fc-receptor-based therapeutics for malaria
    Jianguo Shi
    Institute of Genetics, School of Biology, University of Nottingham NG7 2RD, UK
    Clin Sci (Lond) 110:11-9. 2006
    ..These Abs also aid investigation of immune mechanisms operating to control the disease and are valuable tools in developing neutralization assays for vaccine design. This review explores how this might be achieved...
  73. ncbi Mapping of the neonatal Fc receptor in the rodent eye
    Hyuncheol Kim
    Department of Ophthalmology, Duke University Medical Center, 1530 Erwin, Durham, NC 27705, USA
    Invest Ophthalmol Vis Sci 49:2025-9. 2008
    ..The goal of this study was to localize FcRn receptor expression in the rat's eye...
  74. ncbi FcRn-mediated antibody transport across epithelial cells revealed by electron tomography
    Wanzhong He
    Division of Biology 114 96, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 455:542-6. 2008
    ..Markers for early, late and recycling endosomes each labelled vesicles in different and overlapping morphological classes, revealing spatial complexity in endo-lysosomal trafficking...
  75. ncbi In vivo veritas: the surprising roles of Fc receptors in immunity
    Jeffrey Ravetch
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, New York, USA
    Nat Immunol 11:183-5. 2010
    Jeffrey Ravetch describes how he came to identify the in vivo function of the once mysterious Fc receptors.
  76. ncbi Cytotoxic antibodies trigger inflammation through Fc receptors
    R Clynes
    Program in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Immunity 3:21-6. 1995
    ..Roles have been proposed for Fc receptors, complement, and complement receptors in the pathogenesis of these disorders, although the contribution of each ..
  77. ncbi Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G
    Jinchun Zhou
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9093, USA
    J Mol Biol 332:901-13. 2003
    ..In turn, understanding human FcRn function has significance for the optimization of the serum half-lives of therapeutic and prophylactic antibodies...
  78. ncbi NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant
    Wendy Zhou
    Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    Transpl Immunol 12:9-18. 2003
    ..The human PBMC-NOD/SCID chimera developed by injection of blood group O human PBMC might be a useful in vivo model to test effects of immunosuppressants or other approaches on human B cells that respond to blood group A antigens...
  79. ncbi Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice
    Amit Garg
    Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, Buffalo, NY 14260, USA
    J Pharmacokinet Pharmacodyn 34:687-709. 2007
    ..2 and 0.86 +/- 0.3 in control and FcRn-KO mice. The PBPK model, which incorporates the influence of FcRn on IgG clearance and disposition, was found to provide accurate predictions of IgG tissue kinetics in control and FcRn-knockout mice...
  80. ncbi Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway
    Bonny L Dickinson
    The Research Institute for Children, Children s Hospital, Department of Pediatrics, New Orleans, LA 70118, USA
    Mol Biol Cell 19:414-23. 2008
    ..These results suggest a novel mechanism for regulation of IgG transport by calmodulin-dependent sorting of FcRn and its cargo away from a degradative pathway and into a bidirectional transcytotic route...
  81. ncbi Investigation of IgG receptors expressed on the surface of human placental endothelial cells
    A Gafencu
    Institute of Cellular Biology and Pathology 'Nicolae Simionescu, 8, B.P. Hasdeu Street, POB 35-14, Sect 5, 79691, Bucharest, Romania
    Placenta 24:664-76. 2003
    ....
  82. ncbi Beta 2-microglobulin deficient mice catabolize IgG more rapidly than FcRn- alpha-chain deficient mice
    Jonghan Kim
    Department of Internal Medicine, The Ohio State University, 012K Davis Heart and Lung Research Institute, 473 West Twelfth Avenue, Columbus, OH 43210, USA
    Exp Biol Med (Maywood) 233:603-9. 2008
    ..These results suggest that a beta 2m-associated effect other than FcRn prolongs the survival of both IgG and albumin, although leaky gene transcription in the AK strain cannot be ruled out...
  83. ncbi The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs
    Derry C Roopenian
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 170:3528-33. 2003
    ..FcRn is therefore a promising therapeutic target for enhancing protective humoral immunity, treating autoimmune disease, and improving drug efficacy...
  84. ncbi Pharmacokinetic/pharmacodynamic modeling of the effects of intravenous immunoglobulin on the disposition of antiplatelet antibodies in a rat model of immune thrombocytopenia
    Ryan J Hansen
    Department of Pharmaceutical Sciences, University at Buffalo, The State University at New York, Buffalo, New York 14260, USA
    J Pharm Sci 92:1206-15. 2003
    ..Using these models, it was estimated that 50 +/- 11% of the total protective effect of IVIG in this acute model of ITP can be accounted for by IVIG effects on 7E3 disposition...
  85. ncbi Crystal structure of the ectodomain of human FcalphaRI
    Yi Ding
    Ministry of Education Protein Science Laboratory and Laboratory of Structural Biology, Tsinghua University, Beijing, 100084, China
    J Biol Chem 278:27966-70. 2003
    ..Our data show that FcalphaRI, KIRs, and LIRs share a common hydrophobic core in their interdomain interface, and FcalphaRI is evolutionally closer to LIR than KIR...
  86. ncbi Chromosomal mapping of the high affinity Fc gamma receptor gene
    R J Oakey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710
    Immunogenetics 35:279-82. 1992
  87. ncbi Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn
    Adam R Mezo
    Syntonix Pharmaceuticals, Inc, 9 Fourth Avenue, Waltham, MA 02451, USA
    Proc Natl Acad Sci U S A 105:2337-42. 2008
    ..SYN1436 and related peptides thus represent a previously uncharacterized family of potential therapeutic agents for the treatment of humorally mediated autoimmune and other diseases...
  88. ncbi Podocytes use FcRn to clear IgG from the glomerular basement membrane
    Shreeram Akilesh
    Department of Pathology and Immunology, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:967-72. 2008
    ....
  89. ncbi Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor
    Amita Datta Mannan
    Department of Drug Disposition Development Commercialization and Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 282:1709-17. 2007
    ....
  90. ncbi Engineered human IgG antibodies with longer serum half-lives in primates
    Paul R Hinton
    Protein Design Labs, Inc, Fremont, California 94555, USA
    J Biol Chem 279:6213-6. 2004
    ..5. A pharmacokinetics study of two mutant IgG2 antibodies with increased FcRn binding affinity indicated that they had serum half-lives in rhesus monkeys approximately 2-fold longer than the wild-type antibody...
  91. ncbi Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates
    Amita Datta Mannan
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Drug Metab Dispos 35:86-94. 2007
    ..This work provides further insights into how the FcRn/IgG interaction may be modulated to develop monoclonal antibodies with improved therapeutic properties...
  92. ncbi A novel Fc gamma R-defined, IgG-containing organelle in placental endothelium
    Toshihiro Takizawa
    Department of Physiology and Cell Biology, Ohio State University, Columbus 43210, USA
    J Immunol 175:2331-9. 2005
    ..No IgG-containing organelles are associated with caveolin. These findings are compatible with Fc gammaRIIb-mediated transfer of IgG across the villus endothelium, independent of caveolae...
  93. ncbi Generation and characterization of a novel tetravalent anti-CD22 antibody with improved antitumor activity and pharmacokinetics
    Xiao-Yun Liu
    The Cancer Immunobiology Center, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, NB9.210, Dallas, Texas 75390-8576, USA
    Int Immunopharmacol 6:791-9. 2006
    ..tumor cells, to diffuse into various tissues, to be internalized by Daudi cells, to react with human neonatal Fc receptors (FcRn), and to persist in the circulation of normal mice...
  94. ncbi Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation
    Julia Skokowa
    Department of Clinical Immunology, Medical School Hannover, Hannover, Germany
    J Immunol 174:3041-50. 2005
    ....
  95. ncbi Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn)
    William F Dall'Acqua
    Department of Antibody Discovery and Protein Engineering, MedImmune, Inc, Gaithersburg, Maryland 20878, USA
    J Biol Chem 281:23514-24. 2006
    ..Therefore, the YTE substitutions allow the simultaneous modulation of serum half-life, tissue distribution and activity of a given human IgG1...
  96. ncbi Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction
    Jantine E Bakema
    Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    J Immunol 176:3603-10. 2006
    ..This suggests the involvement of additional amino acids in the FcalphaRI-FcR gamma-chain interaction...
  97. ncbi Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels
    Carlos Vaccaro
    Center for Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390-9093, USA
    Nat Biotechnol 23:1283-8. 2005
    ..Such FcRn blockers (or 'Abdegs,' for antibodies that enhance IgG degradation) may have uses in reducing IgG levels in antibody-mediated diseases and in inducing the rapid clearance of IgG-toxin or IgG-drug complexes...
  98. ncbi Immunohistochemistry in human placental tissue--pitfalls of antigen detection
    Arnd Honig
    Department of Obstetrics and Gynecology, Josef-Schneider-Strasse 4, , Germany
    J Histochem Cytochem 53:1413-20. 2005
    ..any placental EC staining with CD83, HLA-G, and IgG2b isotype control antibodies, presumably by blocking Fc receptors, whereas specific staining patterns remained unchanged...
  99. ncbi Hypercatabolism of IgG in mice with lupus-like syndrome
    J Zhou
    Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Lupus 14:458-66. 2005
    ..The hypercatabolism of IgG was explained by disease-induced impairment of the function of the receptor FcRn, which regulates the homeostasis of IgG...
  100. ncbi Overexpression of the human neonatal Fc-receptor alpha-chain in trophoblast-derived BeWo cells increases cellular retention of beta2-microglobulin
    I Ellinger
    Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    Placenta 26:171-82. 2005
    ..Flow cytometry revealed that beta2m plasma membrane expression was unaffected by alpha-chain overexpression whereas by fluorescence microscopy a preferential staining of beta2m in peripheral endosomes was observed...
  101. ncbi A common site of the Fc receptor gamma subunit interacts with the unrelated immunoreceptors FcalphaRI and FcepsilonRI
    Bruce D Wines
    Helen Macpherson Smith Trust Inflammatory Disease Laboratory, The Macfarlane Burnet Institute for Medical Research and Public Health, Austin Health Campus, Heidelberg, Victoria 3084, Australia
    J Biol Chem 281:17108-13. 2006
    ..of these two nonhomologous receptor interactions on FcRgamma Leu-14 and Leu-21 suggests that all the associated Fc receptors and the activating leukocyte receptor cluster members interact with this one site...

Research Grants76

  1. PHAGOCYTOSIS IN PULMONARY ALVEOLAR MACROPHAGES
    Steven Greenberg; Fiscal Year: 2000
    ..a lymphocyte cell line that expresses a chimerib receptor whose cytosolic domain consists of the y subunit of Fc receptors. We will use lyn-deficient lymphocytes to address the requirement for this tyrosine kinase in pseudopod ..
  2. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
    ..levels of natural IgM and IgG antibodies specific for RTL that would likely bind to and signal through Fc receptors (FcR) when complexed with injected RTL, and it is possible that this pathway involves inhibitory FcR such as Fc?..
  3. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Walker; Fiscal Year: 1993
    ....
  4. Role of autoantibody isotype in pemphigus pathogenesis
    Aimee S Payne; Fiscal Year: 2010
    ..In IgA pemphigus, neutrophilic skin abscesses are caused by anti-Dsg IgA binding to leukocyte Fc receptors, and anti-Dsg IgE may cause eosinophilic forms of pemphigus by analogy...
  5. INTESTINAL AND PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 1999
    ....
  6. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
    ..of expertise will be used to design synthetic peptide and carbohydrate/lipid antigens to investigate how BCR or Fc receptors internalizes and initiate the processing of these antigens to their effective form that induces T cell ..
  7. Clinical Component
    Scott Plevy; Fiscal Year: 2003
    ..In Aim 3, the investigators will evaluate immune responses in microsphere-treated individuals and correlate the results with clinical remission or improvement. ..
  8. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2006
    ..In addition, binding of CRP to phagocytic cells via Fc receptors, with a variety of functional consequences, has been described...
  9. PATHOPHYSIOLOGY OF CRYOGLOBULINEMIC GLOMERULONEPHRITIS
    CHARLES ALPERS; Fiscal Year: 2007
    ..In this proposal, we seek support for studies that will define the role of the immunoglobulin binding Fc receptors (FcR) of leukocytes, major mediators of inflammation in immune complex deposition disease, in this model and ..
  10. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2006
    ..Our preliminary studies have determined that Fc receptors for IgG are critical for antibody effectiveness, and that antibodies do not block bacterial adhesion or entry ..
  11. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard Blumberg; Fiscal Year: 2007
    ..This raises the possibility that blockade of FcRn function may be of therapeutic utility in colitis if our studies support an involvement of FcRn in inflammation. ..
  12. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard Blumberg; Fiscal Year: 2009
    ..This raises the possibility that blockade of FcRn function may be of therapeutic utility in colitis if our studies support an involvement of FcRn in inflammation. ..
  13. Immune activation by cetuximab in head and neck cancer patients
    Robert L Ferris; Fiscal Year: 2010
    ..The lack of this information has negative impact on the development of strategies to optimize cetuximab-based immunotherapy and the selection of patients to be treated. ..
  14. CYTOKINE REGULATION OF RA SYNOVIOCYTE PHENOTYPE
    Lionel B Ivashkiv; Fiscal Year: 2010
    ..Fibrinogen activates signaling via 22 integrins and immune complexes ligate Fc receptors. This finding was surprising, as 22 integrins and Fc receptors signal via immunoreceptor tyrosine-based ..
  15. PROSTATE ANTIGENS/Fc RECEPTORS AND TUMOR IMMUNITY
    Paul Wallace; Fiscal Year: 2001
    ..abstract_text> ..
  16. FcgRIIb protects fetus from allograft rejection
    Clark L Anderson; Fiscal Year: 2010
    ..What function, then, does RIIb serve? One possibility is that villus endothelial Fc receptors serve to trap and eliminate maternal IgG antibodies provoked by and directed toward foreign (paternal) antigen ..
  17. FcgRIIb protects fetus from allograft rejection
    CLARK ANDERSON; Fiscal Year: 2009
    ..What function, then, does RIIb serve? One possibility is that villus endothelial Fc receptors serve to trap and eliminate maternal IgG antibodies provoked by and directed toward foreign (paternal) antigen ..
  18. FcgRIIb protects fetus from allograft rejection
    CLARK ANDERSON; Fiscal Year: 2009
    ..What function, then, does RIIb serve? One possibility is that villus endothelial Fc receptors serve to trap and eliminate maternal IgG antibodies provoked by and directed toward foreign (paternal) antigen ..
  19. Ligand Binding Kinetics and Cell Adhesion by Fc Receptor
    Cheng Zhu; Fiscal Year: 2005
    ..It may also provide guidance to the development of Fc-gamma-R- based drugs for treatment of inflammatory disorders and auto-immune diseases. ..
  20. HUMAN BLOOD MONOCYTE RECEPTOR EXPRESSION AND MODULATION
    Alan Schreiber; Fiscal Year: 1999
    ..It demonstrates that the mode of signalling and the consequences of receptor ligation via the three Fc receptors (FcgammaRI, II, and III and the receptors' A,B,C isoforms) differs with respect to the roles of Ca++, tyrosine ..
  21. ANTIGENIC DETERMINANTS OF VARICELLA VIRUS
    Charles Grose; Fiscal Year: 1993
    ....