fc receptors

Summary

Summary: Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.

Top Publications

  1. ncbi Fcgamma receptors as regulators of immune responses
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054 Erlangen, Germany
    Nat Rev Immunol 8:34-47. 2008
  2. ncbi Roles of Fc receptors in autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology, Japan Science and Technology Corporation, Institute of Development, Ageing and Cancer, Tohoku University, Seiryo, Sendai, Japan
    Nat Rev Immunol 2:580-92. 2002
  3. pmc Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008
  4. ncbi Albumin binding to FcRn: distinct from the FcRn-IgG interaction
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:4983-90. 2006
  5. ncbi Phagocytosis and clearance of apoptotic cells is mediated by MER
    R S Scott
    UNC Neuroscience Center, USA
    Nature 411:207-11. 2001
  6. pmc Role of IgA and IgA fc receptors in inflammation
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:1-9. 2010
  7. ncbi A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection
    T Yoneto
    Department of Allergology and Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 166:6236-41. 2001
  8. ncbi Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)
    A P West
    Division of Biology 156 29 and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 39:9698-708. 2000
  9. pmc Involvement of Fc receptors in disorders of the central nervous system
    Eitan Okun
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuromolecular Med 12:164-78. 2010
  10. pmc Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008

Detail Information

Publications250 found, 100 shown here

  1. ncbi Fcgamma receptors as regulators of immune responses
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054 Erlangen, Germany
    Nat Rev Immunol 8:34-47. 2008
    In addition to their role in binding antigen, antibodies can regulate immune responses through interacting with Fc receptors (FcRs)...
  2. ncbi Roles of Fc receptors in autoimmunity
    Toshiyuki Takai
    Department of Experimental Immunology, Japan Science and Technology Corporation, Institute of Development, Ageing and Cancer, Tohoku University, Seiryo, Sendai, Japan
    Nat Rev Immunol 2:580-92. 2002
  3. pmc Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008
    ....
  4. ncbi Albumin binding to FcRn: distinct from the FcRn-IgG interaction
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:4983-90. 2006
    ..Our results suggest that the FcRn-albumin interaction has unique features distinct from FcRn-IgG binding despite the overall similarity in the pH-dependent binding mechanism by which both ligands are protected from degradation...
  5. ncbi Phagocytosis and clearance of apoptotic cells is mediated by MER
    R S Scott
    UNC Neuroscience Center, USA
    Nature 411:207-11. 2001
    ..Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus...
  6. pmc Role of IgA and IgA fc receptors in inflammation
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:1-9. 2010
    ..However, IgA can also, when aggregated, be deleterious to the host, inducing inflammatory diseases. This Janus-like nature of IgA is mainly due to their heterogeneity in molecular forms and their interaction with IgA receptors...
  7. ncbi A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection
    T Yoneto
    Department of Allergology and Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 166:6236-41. 2001
    ..These results suggest that FcR-mediated Ab-dependent phagocytosis, which is located downstream of IFN-gamma production, is important as an effector mechanism to eliminate PRBC in blood-stage P. berghei XAT infection...
  8. ncbi Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)
    A P West
    Division of Biology 156 29 and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 39:9698-708. 2000
    ..The structure of human FcRn and studies of its ligand binding are relevant to current efforts to use FcRn-mediated regulation of IgG half-life in serum to increase the lifetimes of antibody-based therapeutics...
  9. pmc Involvement of Fc receptors in disorders of the central nervous system
    Eitan Okun
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neuromolecular Med 12:164-78. 2010
    ..Knowledge of the functions of FcRs in the nervous system in health and disease is leading to novel preventative and therapeutic strategies for stroke, Alzheimer's disease, and other neurological disorders...
  10. pmc Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008
    Numerous studies have demonstrated that targeting Ag to Fc receptors (FcR) on APCs can enhance humoral and cellular immunity...
  11. pmc Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level
    Raimund J Ober
    Center for Immunology, University of Texas Southwestern Medical Center, and Department of Electrical Engineering, University of Texas at Dallas, USA
    Proc Natl Acad Sci U S A 101:11076-81. 2004
    ..Such retrograde movement may represent a mechanism for FcRn retrieval. Our studies provide insight into the events that lead to IgG exocytosis...
  12. ncbi The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans
    M Firan
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Immunol 13:993-1002. 2001
    ..FcRn therefore plays a central role in the maternofetal delivery of IgG and this has implications for the use of protein engineering to improve the properties of therapeutic antibodies...
  13. ncbi FcRn: the neonatal Fc receptor comes of age
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:715-25. 2007
    ..This Review summarizes these two areas of FcRn biology...
  14. pmc Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals
    R C Monteiro
    Department of Pediatrics, University of Alabama at Birmingham
    J Clin Invest 92:1681-5. 1993
    ..The data indicate that expression of Fc alpha R molecules with a characteristic glycosylation pattern is upregulated on eosinophils in allergic individuals...
  15. ncbi Fc receptors as determinants of allergic reactions
    Stefan Kraft
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Trends Immunol 27:88-95. 2006
    ..in the positive and negative regulation of Fc receptor expression and signaling have shed light on the role of Fc receptors in our immune system, indicating them to be bifunctional, inhibitory and activating structures...
  16. ncbi Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn
    Raimund J Ober
    Cancer Immunobiology Center and Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 172:2021-9. 2004
    ..The studies provide a dynamic view of the trafficking of FcRn and its ligand and have relevance to understanding how FcRn functions to maintain IgG homeostasis...
  17. ncbi Immunoglobulin transport across polarized epithelial cells
    Raul Rojas
    Laboratory of Epithelial Cell Biology, Renal Electrolyte Division of the Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Nat Rev Mol Cell Biol 3:944-55. 2002
    ..Recent studies on the intracellular transport pathways of antibody-receptor complexes and antibody-stimulated receptor-mediated transcytosis are providing new insight into the nature and regulation of endocytic pathways...
  18. ncbi Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding
    W L Martin
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell 7:867-77. 2001
    ..The structure reveals conformational changes in Fc and three titratable salt bridges that confer pH-dependent binding, and can be used to guide rational design of therapeutic IgGs with longer serum half-lives...
  19. ncbi Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells
    Gøril Berntzen
    Department of Molecular Biosciences, University of Oslo, P O Box 1041, 0316, Oslo, Norway
    J Immunol Methods 298:93-104. 2005
    ..The approach should be of interest to laboratories that do not have access to a bioreactor but still have a requirement for reasonable amounts of protein to be produced in an easy and cost-effective manner...
  20. pmc Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn
    E J Israel
    Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    Immunology 89:573-8. 1996
    ..These data suggest that FcRn can protect IgG from degradation, and is therefore important in maintaining IgG levels in the circulation...
  21. ncbi Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Nature 344:742-6. 1990
    ....
  22. ncbi Fc receptors and immunity to parasites
    R J Pleass
    Dept of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, DD1 9SY, Dundee, UK
    Trends Parasitol 17:545-51. 2001
    b>Fc receptors (FcRs) are crucial in the immune system; they mediate a plethora of biological functions as diverse as antigen presentation, phagocytosis, cytotoxicity, induction of inflammatory cascades and modulation of immune responses...
  23. doi Complement, Fc receptors and antibodies: a Trojan horse in HIV infection?
    Heribert Stoiber
    Section of Hygiene and Microbiology, Innsbruck Medical University, Innsbruck, Austria
    Curr Opin HIV AIDS 4:394-9. 2009
    ..Thus, immediately upon entering the host, independent on the route of infection, HIV activates the complement system. Although a first line of immune defense, complement cannot eliminate retroviral infections completely...
  24. ncbi Fc receptor but not complement binding is important in antibody protection against HIV
    Ann J Hessell
    Department of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 449:101-4. 2007
    ..Overall, the data suggest the potential importance of activity against both infected cells and free virus for effective protection against HIV...
  25. pmc MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells
    X Zhu
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:3266-76. 2001
    ....
  26. ncbi Tryptophan- and dileucine-based endocytosis signals in the neonatal Fc receptor
    Z Wu
    Rosenstiel Center for Basic Biomedical Sciences, W. M. Keck Institute for Cellular Visualization, Brandeis University, Waltham, MA 02254-9110, USA
    J Biol Chem 276:5240-7. 2001
    ..This shift appeared to arise because the loss of endocytosis signals inhibited apical to basolateral transcytosis of FcRn more than basolateral to apical transcytosis...
  27. ncbi Decoding IgE Fc receptors
    Ming Zhang
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Res 37:1-16. 2007
    ..A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively...
  28. pmc A full complement of receptors in immune complex diseases
    Jeffrey V Ravetch
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, New York 10021, USA
    J Clin Invest 110:1759-61. 2002
  29. pmc Dependence of antibody-mediated presentation of antigen on FcRn
    Shuo Wang Qiao
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:9337-42. 2008
    ....
  30. ncbi Fc receptors as potential targets for the treatment of allergy, autoimmune disease and cancer
    Toshiyuki Takai
    Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 3:187-97. 2003
    ..On the contrary, activating-type Fc receptors are crucial for the onset and exacerbation of such diseases...
  31. pmc A synthetic mimic of human Fc receptors: defined chemical modification of cell surfaces enables efficient endocytic uptake of human immunoglobulin-G
    Siwarutt Boonyarattanakalin
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Am Chem Soc 128:11463-70. 2006
    ..Certain human leukocytes and epithelial cells express Fc receptors (FcRs) that bind and internalize antibodies through this mechanism...
  32. ncbi Human anti-idiotypic antibodies can be good immunogens as they target FC receptors on antigen-presenting cells allowing efficient stimulation of both helper and cytotoxic T-cell responses
    L G Durrant
    CRC Academic Unit of Clinical Oncology, University of Nottingham, City Hospital, Nottingham, United Kingdom
    Int J Cancer 92:414-20. 2001
    ..Human anti-idiotypes are therefore good immunogens since they target Fc receptors on antigen-presenting cells, allowing efficient stimulation of both helper and cytotoxic T-cell responses...
  33. ncbi Polyclonal immunoglobulins (IVIg) modulate nitric oxide production and microglial functions in vitro via Fc receptors
    M Stangel
    Department of Neurology, Universitatsklinikum Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Neuroimmunol 112:63-71. 2001
    ..inhibition of Syk and phosphatidylinositol 3-kinase, two enzymes involved in the signalling cascade of Fc receptors. TNFalpha secretion was dose-dependently stimulated by IVIg in both untreated microglia and after stimulation ..
  34. pmc Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors
    Stephen L Sazinsky
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:20167-72. 2008
    ....
  35. ncbi Cross-talk between Fc receptors and integrins
    Alejandro Ortiz-Stern
    Department of Immunology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Apartado Postal 70228, Ciudad Universitaria, Mexico D F, C P 04510, Mexico
    Immunol Lett 90:137-43. 2003
    b>Fc receptors (FcRs) and integrins are both key players of immune responses. These receptors are capable of independent signaling that leads to various cell functions...
  36. pmc IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution
    T S Ramalingam
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 21:590-601. 2002
    ....
  37. ncbi Antibodies, Fc receptors and cancer
    Falk Nimmerjahn
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Opin Immunol 19:239-45. 2007
    ..These novel insights into antibody FcR interactions might be useful to produce the next generation of improved immunotherapeutic molecules...
  38. ncbi Channel catfish NK-like cells are armed with IgM via a putative FcmicroR
    Linling Shen
    Department of Microbiology, University of Mississippi, Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Dev Comp Immunol 27:699-714. 2003
    ..This is the first report suggesting that teleost NK-like cells express a putative FcmicroR which participates in antibody-dependent cell-mediated cytotoxicity...
  39. ncbi Fc receptor biology
    M Daeron
    Laboratoire d Immunologie Cellulaire et Clinique, INSERM U 255, Institut Curie, Paris, France
    Annu Rev Immunol 15:203-34. 1997
    This review deals with membrane Fc receptors (FcR) of the immunoglobulin superfamily. It is focused on the mechanisms by which FcR trigger and regulate biological responses of cells on which they are expressed...
  40. ncbi Human NK cells express Fc receptors for IgA which mediate signal transduction and target cell killing
    Gabriela Mota
    Center of Immunology, Institute of Virology, Bucharest, Romania
    Eur J Immunol 33:2197-205. 2003
    ..In this work the expression of Fc receptors for IgA (FcalphaR) on human NK cells and the signaling events were investigated...
  41. ncbi The role of IgA and IgA Fc receptors as anti-inflammatory agents
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:S61-4. 2010
    ....
  42. pmc Microglial Fc receptors mediate physiological changes resulting from antibody cross-linking of myelin oligodendrocyte glycoprotein
    Cecilia B Marta
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, United States
    J Neuroimmunol 196:35-40. 2008
    ..Here, we show that similar events occur when anti-MOG is cross-linked with Fc receptors (FcRs) present on microglia but not with complement...
  43. pmc Rhesus macaque polyclonal and monoclonal antibodies inhibit simian immunodeficiency virus in the presence of human or autologous rhesus effector cells
    Donald N Forthal
    Department of Medicine, Division of Infectious Diseases, School of Medicine, University of California Irvine, Irvine, CA 92697 4028, USA
    J Virol 80:9217-25. 2006
    ..Finally, our data underscore the potential importance of Fc-Fc receptor interactions in mediating biological activities of antibody...
  44. pmc Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis
    Ekaterina Maidji
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, San Francisco, San Francisco, CA 94143 0512, USA
    Am J Pathol 168:1210-26. 2006
    ..These findings could explain the efficacy of hyperimmune IgG for treatment of primary CMV infection during gestation and support vaccination...
  45. ncbi Crystal structure of the complex of rat neonatal Fc receptor with Fc
    W P Burmeister
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125
    Nature 372:379-83. 1994
    ..4) and suggesting an unusual orientation of FcRn on the membrane...
  46. ncbi Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4+ T lymphocytes
    Thijs van Montfort
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, Meibergdreef 15, Amsterdam, The Netherlands
    J Immunol 178:3177-85. 2007
    ..The increased capture of the 2F5-neutralized virus by iMDDCs was negated upon blocking the Fc receptors. Blocking DC-SIGN on iMDDCs resulted in a 70-75% inhibition of HIV-1 capture at 37 degrees C, whereas at 4 ..
  47. pmc Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung
    Gerburg M Spiekermann
    The Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Boston, MA 02115, USA
    J Exp Med 196:303-10. 2002
    ..These data show that mucosal surfaces that express FcRn reabsorb IgG and explain a mechanism by which IgG may act in immune surveillance to retrieve lumenal antigens for processing in the lamina propria or systemically...
  48. ncbi Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors
    John C Martyn
    The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Vic, Australia
    Arch Virol 154:1129-38. 2009
    ..to recombinant soluble FcgammaRIIalpha receptor and to cell lines and antigen-presenting cells expressing Fc receptors (FcRs)...
  49. ncbi A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
    L Borges
    Immunex Corp, Seattle, WA 98101, USA
    J Immunol 159:5192-6. 1997
    ..Like killer inhibitory receptors, at least two LIRs bind to MHC class I Ags, but their different cellular distribution suggests a distinct role in immune system modulation...
  50. ncbi An Fc receptor structurally related to MHC class I antigens
    N E Simister
    Whitehead Institute for Biomedical Research, Nine Cambridge, Massachusetts 02142
    Nature 337:184-7. 1989
    ..b>Fc receptors on intestinal epithelial cells of the neonatal rat (FcRn) mediate the uptake of IgG from milk...
  51. ncbi Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    Masaru Yoshida
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunity 20:769-83. 2004
    ..These results explain how IgG is secreted onto mucosal surfaces and scavenges luminal antigens for recognition by the immune system...
  52. pmc Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells
    Gotz R A Ehrhardt
    Division of Clinical and Developmental Immunology, University of Alabama at Birmingham, Birmingham, Birmingham, AL 35294, USA
    J Exp Med 202:783-91. 2005
    ..Cell surface FcRH4 expression thus marks a unique population of memory B cells with distinctive morphology, functional capabilities, and tissue localization...
  53. ncbi IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells
    Ira Miller
    Institute of Cancer Genetics and the Department of Pathology, Columbia University, New York, NY 10032, USA
    Blood 99:2662-9. 2002
    ..All IRTA genes code for transmembrane receptors that are closely related to Fc receptors in their most amino-terminal extracellular domains and that possess cytoplasmic domains containing ITIM (..
  54. ncbi Fc receptors
    J V Ravetch
    DeWitt Wallace Research Laboratories, Sloan Kettering Institute for Cancer Research, New York, New York 10021
    Annu Rev Immunol 9:457-92. 1991
    ..The detailed analysis of the IgG and IgE Fc receptors has indicated that these molecules have evolved from a common precursor through gene duplication...
  55. ncbi Fc receptors: rubor redux
    J V Ravetch
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 78:553-60. 1994
  56. ncbi IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor
    Rashid Deane
    Division of Neurovascular Biology, Department of Neurosurgery, Arthur Kornberg Medical Research Building, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 25:11495-503. 2005
    ..Our data suggest that the FcRn pathway at the BBB plays a crucial role in IgG-assisted Abeta removal from the aging brain...
  57. ncbi Species-specific evolution of the FcR family in endothermic vertebrates
    Svetlana A Fayngerts
    Laboratory of Immunogenetics, Institute of Cytology and Genetics, Novosibirsk, Russia
    Immunogenetics 59:493-506. 2007
    ....
  58. ncbi Immature neutrophils mediate tumor cell killing via IgA but not IgG Fc receptors
    Marielle A Otten
    Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, The Netherlands
    J Immunol 174:5472-80. 2005
    ..This may provide a rationale for the disappointing results observed in some earlier clinical trials in which patients were treated with G-CSF and antitumor Ab-targeting FcgammaR...
  59. ncbi Regulation of antibody responses via antibodies, complement, and Fc receptors
    B Heyman
    Department of Genetics and Pathology, Uppsala University, Sweden
    Annu Rev Immunol 18:709-37. 2000
    ..IgG can enhance primary antibody responses in the absence of the complement system and seems to be dependent on Fc receptors for IgG (FcgammaRs). IgE enhances antibody responses via the low-affinity receptor for IgE (FcepsilonRII/CD23)...
  60. ncbi Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung
    Masahiro Sakagami
    Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, 23298 0533, USA
    Pharm Res 23:270-9. 2006
    ..FcRn expression in the upper tracheobronchial airways of the lung is recognized. In this study, we sought to characterize the functional expression of FcRn within alveolar regions of lung tissue...
  61. pmc Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors
    Meili Zhang
    Metabolism Branch, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 108:705-10. 2006
    ..We demonstrated that the expression of FcRgamma on polymorphonuclear leukocytes and monocytes was not required for HeFi-1-mediated tumor growth inhibition in vivo, although it was required for daclizumab...
  62. ncbi Fc receptors are major mediators of antibody based inflammation in autoimmunity
    P Mark Hogarth
    Helen McPherson Smith Laboratory, Austin Research Institute, Heidelberg, Vic, Australia
    Curr Opin Immunol 14:798-802. 2002
    ..Of increasing interest are Fc receptors, which have been more closely investigated in the past decade using recombinant proteins, gene deficient mice ..
  63. ncbi Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity
    Michaela Robbie-Ryan
    Graduate Program in Immunology and Molecular Pathogenesis, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 170:1630-4. 2003
    ..Notably, mice reconstituted with FcgammaRIII(-/-) BMMC exhibit a relapsing-remitting course of disease. These data demonstrate that both activating and inhibitory FcRs expressed on mast cells influence the course of EAE...
  64. ncbi The impact of Fc receptors on the development of autoimmune diseases
    S Kleinau
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Curr Pharm Des 9:1861-70. 2003
    ..of autoantibodies to self-antigens, which initiate an inflammatory response through binding to immunoglobulin Fc receptors (FcRs) or via complement components...
  65. ncbi Transmembrane domains in the functions of Fc receptors
    Raphael Zidovetzki
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Biophys Chem 100:555-75. 2003
    ....
  66. pmc Myosin vb is associated with plasma membrane recycling systems
    L A Lapierre
    Departments of Medicine, Surgery, and Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia 30912, USA
    Mol Biol Cell 12:1843-57. 2001
    ..The dominant negative effects of the myosin Vb tail chimera indicate that this unconventional myosin is required for transit out of plasma membrane recycling systems...
  67. ncbi Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo
    Jiri Trcka
    The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center and Weill Graduate School of Cornell University, New York, NY 10021, USA
    Immunity 16:861-8. 2002
    ..Thus, either complement or macrophages expressing activating Fc gamma R can independently and alternatively mediate disease in a model of autoimmune vitiligo...
  68. ncbi Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family
    Randall S Davis
    Division of Hematology Oncology, University of Alabama at Birmingham, AL 35294, USA
    Immunol Rev 190:123-36. 2002
    Newfound relatives of the classical Fc receptors (FcR) have been provisionally named the Fc receptor homologs (FcRH)...
  69. ncbi Channel catfish cytotoxic cells: a mini-review
    Linling Shen
    Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Dev Comp Immunol 26:141-9. 2002
    ..The availability of various cloned cytotoxic cell lines should enable unambiguous functional studies to be performed in ways not currently possible with any other fish species...
  70. ncbi A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1
    Sergei V Guselnikov
    Laboratory of Immunogenetics, Institute of Cytology and Genetics, Lavrentjev St 10, Novosibirsk 630090, Russia
    Immunogenetics 54:87-95. 2002
    A group of genes encoding proteins structurally related to the leukocyte Fc receptors (FcRs) and termed the IFGP family was identified in human and mouse...
  71. pmc Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor
    Steven M Claypool
    Harvard Medical School, Program in Immunology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Mol Biol Cell 15:1746-59. 2004
    ..Thus, the strong cell surface polarity displayed by hFcRn results from dominant basolateral sorting by motifs in the cytoplasmic tail that nonetheless allows for a cycle of bidirectional transcytosis...
  72. ncbi Human antibody-Fc receptor interactions illuminated by crystal structures
    Jenny M Woof
    Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
    Nat Rev Immunol 4:89-99. 2004
    ..classes trigger different effector mechanisms through interaction of immunoglobulin Fc regions with specific Fc receptors (FcRs) on immune cells...
  73. ncbi Bivalent binding of IgA1 to FcalphaRI suggests a mechanism for cytokine activation of IgA phagocytosis
    Andrew B Herr
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Mol Biol 327:645-57. 2003
    ..The bivalent, pH-dependent interaction between FcalphaRI and IgA has important implications for cytokine-dependent phagocytosis of IgA and the FcalphaRI-mediated degradation or recycling of IgA...
  74. ncbi Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells
    Randall S Davis
    Division of Hematology Oncology, University of Alabama, Bimingham 35294, USA
    Int Immunol 14:1075-83. 2002
    ..FcRX transcripts are found primarily in secondary lymphoid tissues, where they are expressed by B lineage cells. FcRX thus may function as a secreted or intracellular protein in normal and neoplastic B cells...
  75. ncbi Neonatal Fc receptors discriminates and monitors the pathway of native and modified immunoglobulin G in placental endothelial cells
    Luminita Radulescu
    Institute of Cellular Biology and Pathology Nicolae Simionescu, 8, B P Hasdeu Street, Bucharest, 79691, Romania
    Hum Immunol 65:578-85. 2004
    ..We questioned the role of neonatal Fc receptors (FcRn) in the traffic of IgG in human placental endothelial cells (HPEC)...
  76. pmc Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin
    Steven M Claypool
    Harvard Medical School, Program in Immunology, Gastroenterogy Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 277:28038-50. 2002
    ..These results show that human FcRn travels to the cell surface via the normal secretory pathway and that the appropriate expression and function of human FcRn in MDCK cells depends upon the co-expression of human beta(2)m...
  77. pmc Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor
    Devin B Tesar
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Traffic 7:1127-42. 2006
    ..We also demonstrate that hdFc and wtFc have different intracellular fates, with more hdFc than wtFc being trafficked to lysosomes and degraded, suggesting a role for avidity effects in FcRn-mediated IgG transport...
  78. pmc Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene
    Manzoor A Wani
    Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:5084-9. 2006
    ..This experiment of nature affirms our hypothesis that FcRn binds IgG and albumin, salvages both from a degradative fate, and maintains their physiologic concentrations...
  79. pmc Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors
    Yoshikatsu Kaneko
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:789-97. 2006
    ..These results establish the significance of specific IgG subclasses and their cognate FcgammaRs in renal disease...
  80. ncbi Cytotoxic antibodies trigger inflammation through Fc receptors
    R Clynes
    Program in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Immunity 3:21-6. 1995
    ..Roles have been proposed for Fc receptors, complement, and complement receptors in the pathogenesis of these disorders, although the contribution of each ..
  81. pmc How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis
    Shuo Wang Qiao
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunology 120:145-7. 2007
  82. pmc Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn
    C J Fitzer-Attas
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California 94143, USA
    J Exp Med 191:669-82. 2000
    ..Since FcgammaR-mediated phagocytosis did occur at modest levels in a delayed fashion in triple mutant macrophages, these Src family kinases are not absolutely required for uptake of IgG-opsonized particles...
  83. pmc Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors
    Eric T Harvill
    Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802, USA
    Infect Immun 76:2177-82. 2008
    ..anthracis-challenged mice. Adoptively transferred sera were protective in mice lacking complement, Fc receptors, or both, suggesting that they operate independent of these effectors...
  84. ncbi Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89
    R J Pleass
    Department of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    J Biol Chem 274:23508-14. 1999
    ..We have thus identified motifs in the interdomain region of IgA Fc critical for FcalphaR binding and triggering, significantly enhancing present understanding of the molecular basis of the IgA-FcalphaR interaction...
  85. ncbi Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus
    Qingshun Lin
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 177:1646-54. 2006
    Immune complex (IC)-mediated tissue inflammation is controlled by stimulatory and inhibitory IgG Fc receptors (FcgammaRs)...
  86. doi In vivo veritas: the surprising roles of Fc receptors in immunity
    Jeffrey Ravetch
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, New York, USA
    Nat Immunol 11:183-5. 2010
    Jeffrey Ravetch describes how he came to identify the in vivo function of the once mysterious Fc receptors.
  87. ncbi Antibody- and Fc-receptor-based therapeutics for malaria
    Jianguo Shi
    Institute of Genetics, School of Biology, University of Nottingham NG7 2RD, UK
    Clin Sci (Lond) 110:11-9. 2006
    ..These Abs also aid investigation of immune mechanisms operating to control the disease and are valuable tools in developing neutralization assays for vaccine design. This review explores how this might be achieved...
  88. pmc Mapping of the neonatal Fc receptor in the rodent eye
    Hyuncheol Kim
    Department of Ophthalmology, Duke University Medical Center, 1530 Erwin, Durham, NC 27705, USA
    Invest Ophthalmol Vis Sci 49:2025-9. 2008
    ..The goal of this study was to localize FcRn receptor expression in the rat's eye...
  89. ncbi IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy
    G Hatzivassiliou
    Institute of Cancer Genetics, Columbia University, New York, NY 10032, USA
    Immunity 14:277-89. 2001
    ..In tumor cell lines with 1q21 abnormalities, IRTA2 expression is deregulated. Thus, IRTA1 and IRTA2 are novel immunoreceptors implicated in B cell development and lymphomagenesis...
  90. pmc FcRn-mediated antibody transport across epithelial cells revealed by electron tomography
    Wanzhong He
    Division of Biology 114 96, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 455:542-6. 2008
    ..Markers for early, late and recycling endosomes each labelled vesicles in different and overlapping morphological classes, revealing spatial complexity in endo-lysosomal trafficking...
  91. ncbi Effects of mutations in potential phosphorylation sites on transcytosis of FcRn
    K M McCarthy
    Rosenstiel Center for Basic Biomedical Sciences, W. M. Keck Institute for Cellular Visualization, and Biology Department, Brandeis University, Waltham, MA 02254-9110, USA
    J Cell Sci 114:1591-8. 2001
    ..FcRn-S313A recycled more Fc to the apical medium than the wild-type receptor, suggesting that Ser-313 is required to allow FcRn to be diverted from an apical recycling pathway to a transcytotic pathway...
  92. ncbi Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types
    Yutaka Kanda
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, 3 6 6 Asahi machi, Machida shi, Tokyo 194 8533, Japan
    Glycobiology 17:104-18. 2007
    ..The present study provides basic information on the effects of core fucose-lacking N-linked Fc oligosaccharides on antibody biological activities...
  93. ncbi Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G
    Jinchun Zhou
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9093, USA
    J Mol Biol 332:901-13. 2003
    ..In turn, understanding human FcRn function has significance for the optimization of the serum half-lives of therapeutic and prophylactic antibodies...
  94. ncbi Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates
    Amita Datta-Mannan
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Drug Metab Dispos 35:86-94. 2007
    ..This work provides further insights into how the FcRn/IgG interaction may be modulated to develop monoclonal antibodies with improved therapeutic properties...
  95. ncbi NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant
    Wendy Zhou
    Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Transpl Immunol 12:9-18. 2003
    ..The human PBMC-NOD/SCID chimera developed by injection of blood group O human PBMC might be a useful in vivo model to test effects of immunosuppressants or other approaches on human B cells that respond to blood group A antigens...
  96. ncbi Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor
    Amita Datta-Mannan
    Department of Drug Disposition Development Commercialization and Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 282:1709-17. 2007
    ....
  97. ncbi Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice
    Amit Garg
    Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, Buffalo, NY 14260, USA
    J Pharmacokinet Pharmacodyn 34:687-709. 2007
    ..2 and 0.86 +/- 0.3 in control and FcRn-KO mice. The PBPK model, which incorporates the influence of FcRn on IgG clearance and disposition, was found to provide accurate predictions of IgG tissue kinetics in control and FcRn-knockout mice...
  98. pmc Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway
    Bonny L Dickinson
    The Research Institute for Children, Children s Hospital, Department of Pediatrics, New Orleans, LA 70118, USA
    Mol Biol Cell 19:414-23. 2008
    ..These results suggest a novel mechanism for regulation of IgG transport by calmodulin-dependent sorting of FcRn and its cargo away from a degradative pathway and into a bidirectional transcytotic route...
  99. pmc Podocytes use FcRn to clear IgG from the glomerular basement membrane
    Shreeram Akilesh
    Department of Pathology and Immunology, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:967-72. 2008
    ....
  100. pmc Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn
    Adam R Mezo
    Syntonix Pharmaceuticals, Inc, 9 Fourth Avenue, Waltham, MA 02451, USA
    Proc Natl Acad Sci U S A 105:2337-42. 2008
    ..SYN1436 and related peptides thus represent a previously uncharacterized family of potential therapeutic agents for the treatment of humorally mediated autoimmune and other diseases...
  101. ncbi Investigation of IgG receptors expressed on the surface of human placental endothelial cells
    A Gafencu
    Institute of Cellular Biology and Pathology Nicolae Simionescu, 8, B P Hasdeu Street, POB 35 14, Sect 5, 79691, Bucharest, Romania
    Placenta 24:664-76. 2003
    ....

Research Grants77

  1. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 1993
    ..MHC genes and other genes playing important roles in the immune system (including T cell receptors, integrins, Fc receptors, the C3/C4/C5 complement component family, and the ABC family of transmembrane transporters)...
  2. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2009
    ..major hypotheses regarding the actions of A( immunotherapy are the facilitation of microglial phagocytosis via Fc receptors and promotion of A( removal from the brain by increasing the brain/blood concentration gradient via anti-A( ..
  3. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..Project Description Page 6 ..
  4. Key determinants of dengue virus neutralization by naturally occurring human mAbs
    Scott A Smith; Fiscal Year: 2012
    ..These skills, along with didactic coursework, will help me to develop my career, as a physician-scientist, in a direction independently of my mentor. ..
  5. PHAGOCYTOSIS IN PULMONARY ALVEOLAR MACROPHAGES
    Steven Greenberg; Fiscal Year: 2000
    ..a lymphocyte cell line that expresses a chimerib receptor whose cytosolic domain consists of the y subunit of Fc receptors. We will use lyn-deficient lymphocytes to address the requirement for this tyrosine kinase in pseudopod ..
  6. PHAGOCYTOSIS IN PULMONARY ALVEOLAR MACROPHAGES
    Steven Greenberg; Fiscal Year: 1999
    ..a lymphocyte cell line that expresses a chimerib receptor whose cytosolic domain consists of the y subunit of Fc receptors. We will use lyn-deficient lymphocytes to address the requirement for this tyrosine kinase in pseudopod ..
  7. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Walker; Fiscal Year: 1993
    ....
  8. Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?
    Bryce Binstadt; Fiscal Year: 2010
    ..Arthritis in this mouse model depends primarily on complement C5 and not Fc receptors;conversely, endocarditis depends essentially on Fc receptors and not C5...
  9. Role of autoantibody isotype in pemphigus pathogenesis
    Aimee S Payne; Fiscal Year: 2010
    ..In IgA pemphigus, neutrophilic skin abscesses are caused by anti-Dsg IgA binding to leukocyte Fc receptors, and anti-Dsg IgE may cause eosinophilic forms of pemphigus by analogy...
  10. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
    ..levels of natural IgM and IgG antibodies specific for RTL that would likely bind to and signal through Fc receptors (FcR) when complexed with injected RTL, and it is possible that this pathway involves inhibitory FcR such as Fc?..
  11. Protective Human Monoclonal Antibodies to HIV-1
    Susan Zolla Pazner; Fiscal Year: 2009
    ..These antibodies could also be used to develop products to treat HIV infection when used in conjunction with anti-retroviral drugs. ..
  12. Protective immunity against HIV: the role of IgG subclass and glycosylation
    Donald Forthal; Fiscal Year: 2009
    Project Summary Engagement of IgG Fc receptors (Fc?Rs) on natural killer cells, monocytes, macrophages, or dendritic cells may play a critical role in preventing lentivirus infection...
  13. INTESTINAL & PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 2000
    ..Lastly, the proposed work almost completes the studies that follow directly from the discovery by the P.I. of MHC class I-related FcRs, and additional time will be essential to consider and plan future research directions. ..
  14. INTESTINAL & PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 1999
    ..Lastly, the proposed work almost completes the studies that follow directly from the discovery by the P.I. of MHC class I-related FcRs, and additional time will be essential to consider and plan future research directions. ..
  15. Protective immunity against HIV: the role of IgG subclass and glycosylation
    Donald Forthal; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Engagement of IgG Fc receptors (Fc?Rs) on natural killer cells, monocytes, macrophages, or dendritic cells may play a critical role in preventing lentivirus infection...
  16. ROLE OF MONONUCLEAR LEUKOCYTES IN IMMUNITY
    Samuel Silverstein; Fiscal Year: 1990
    ....
  17. INTESTINAL AND PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 1999
    ....
  18. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
    ..of expertise will be used to design synthetic peptide and carbohydrate/lipid antigens to investigate how BCR or Fc receptors internalizes and initiate the processing of these antigens to their effective form that induces T cell ..
  19. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2006
    ..In addition, binding of CRP to phagocytic cells via Fc receptors, with a variety of functional consequences, has been described...
  20. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2004
    ..In addition, binding of CRP to phagocytic cells via Fc receptors, with a variety of functional consequences, has been described...
  21. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2002
    ..In addition, binding of CRP to phagocytic cells via Fc receptors, with a variety of functional consequences, has been described...
  22. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2003
    ..In addition, binding of CRP to phagocytic cells via Fc receptors, with a variety of functional consequences, has been described...
  23. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2002
    ..In addition, binding of CRP to phagocytic cells via Fc receptors, with a variety of functional consequences, has been described...
  24. Structure-Function Relationships of C-Reactive Protein
    Alok Agrawal; Fiscal Year: 2005
    ..In addition, binding of CRP to phagocytic cells via Fc receptors, with a variety of functional consequences, has been described...
  25. PATHOPHYSIOLOGY OF CRYOGLOBULNEMIC GLOMERULONEPHRITIS
    CHARLES ALPERS; Fiscal Year: 2005
    ..In this proposal, we seek support for studies that will define the role of the immunoglobulin binding Fc receptors (FcR) of leukocytes, major mediators of inflammation in immune complex deposition disease, in this model and ..
  26. PATHOPHYSIOLOGY OF CRYOGLOBULNEMIC GLOMERULONEPHRITIS
    CHARLES ALPERS; Fiscal Year: 2006
    ..In this proposal, we seek support for studies that will define the role of the immunoglobulin binding Fc receptors (FcR) of leukocytes, major mediators of inflammation in immune complex deposition disease, in this model and ..
  27. PATHOPHYSIOLOGY OF CRYOGLOBULINEMIC GLOMERULONEPHRITIS
    CHARLES ALPERS; Fiscal Year: 2004
    ..In this proposal, we seek support for studies that will define the role of the immunoglobulin binding Fc receptors (FcR) of leukocytes, major mediators of inflammation in immune complex deposition disease, in this model and ..
  28. PATHOPHYSIOLOGY OF CRYOGLOBULINEMIC GLOMERULONEPHRITIS
    CHARLES ALPERS; Fiscal Year: 2007
    ..In this proposal, we seek support for studies that will define the role of the immunoglobulin binding Fc receptors (FcR) of leukocytes, major mediators of inflammation in immune complex deposition disease, in this model and ..
  29. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2004
    ..Our preliminary studies have determined that Fc receptors for IgG are critical for antibody effectiveness, and that antibodies do not block bacterial adhesion or entry ..
  30. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2005
    ..Our preliminary studies have determined that Fc receptors for IgG are critical for antibody effectiveness, and that antibodies do not block bacterial adhesion or entry ..
  31. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2006
    ..Our preliminary studies have determined that Fc receptors for IgG are critical for antibody effectiveness, and that antibodies do not block bacterial adhesion or entry ..
  32. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2003
    ..Our preliminary studies have determined that Fc receptors for IgG are critical for antibody effectiveness, and that antibodies do not block bacterial adhesion or entry ..
  33. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2002
    ..Our preliminary studies have determined that Fc receptors for IgG are critical for antibody effectiveness, and that antibodies do not block bacterial adhesion or entry ..
  34. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard Blumberg; Fiscal Year: 2009
    ..This raises the possibility that blockade of FcRn function may be of therapeutic utility in colitis if our studies support an involvement of FcRn in inflammation. ..
  35. INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFE
    Richard Blumberg; Fiscal Year: 2007
    ..This raises the possibility that blockade of FcRn function may be of therapeutic utility in colitis if our studies support an involvement of FcRn in inflammation. ..
  36. Recombinant Fc receptor therapeutics for systemic lupus erythematosus
    Periasamy Selvaraj; Fiscal Year: 2009
    ..affinity of Fc3Rs, which necessitates the administration of physiologically unattainable levels of recombinant Fc receptors. Furthermore, the high level of circulating IgG immediately will neutralize the action of high affinity ..
  37. Recombinant Fc receptor therapeutics for systemic lupus erythematosus
    Periasamy Selvaraj; Fiscal Year: 2010
    ..affinity of Fc3Rs, which necessitates the administration of physiologically unattainable levels of recombinant Fc receptors. Furthermore, the high level of circulating IgG immediately will neutralize the action of high affinity ..
  38. SYNCYTIOTROPHOBLAST IGG FC RECEPTORS AND HIV INFECTION
    Daniel Sedmak; Fiscal Year: 1991
    ....
  39. Immune activation by cetuximab in head and neck cancer patients
    Robert L Ferris; Fiscal Year: 2010
    ..The lack of this information has negative impact on the development of strategies to optimize cetuximab-based immunotherapy and the selection of patients to be treated. ..
  40. Clinical Component
    Scott Plevy; Fiscal Year: 2003
    ..In Aim 3, the investigators will evaluate immune responses in microsphere-treated individuals and correlate the results with clinical remission or improvement. ..
  41. CYTOKINE REGULATION OF RA SYNOVIOCYTE PHENOTYPE
    Lionel B Ivashkiv; Fiscal Year: 2010
    ..Fibrinogen activates signaling via 22 integrins and immune complexes ligate Fc receptors. This finding was surprising, as 22 integrins and Fc receptors signal via immunoreceptor tyrosine-based ..
  42. Function of Phospholipase Cgamma2 in RANKL-Induced Osteoclastogenesis
    Yabing Chen; Fiscal Year: 2010
    ....
  43. Function of Phospholipase Cgamma2 in RANKL-Induced Osteoclastogenesis
    Yabing Chen; Fiscal Year: 2009
    ....
  44. Role of Macrophage Activation in Carotid Plaque Instability
    MICHELLE LENNARTZ; Fiscal Year: 2009
    ..Our data suggest that FcR signaling in involved in the development of unstable plaques. This research will determine the role of FcgR in plaque progression and rupture and provide novel targets for reducing heart attack and stroke. ..
  45. Role of Macrophage Activation in Carotid Plaque Instability
    Michelle R Lennartz; Fiscal Year: 2010
    ..Our data suggest that FcR signaling in involved in the development of unstable plaques. This research will determine the role of FcgR in plaque progression and rupture and provide novel targets for reducing heart attack and stroke. ..
  46. ROLE OF FC RECEPTOR IN THE AFFERENT LIMB OF THE AUTOIMMUNE RESPONSE
    Jeffrey Ravetch; Fiscal Year: 1999
    ..These immune responses will be compared to those displayed by autoimmune strains of mice. These studies will further explore the role of antibody receptors in autoimmune disease and may identify new targets for therapeutic intervention. ..
  47. IGA FC RECEPTORS
    JULIA PHILLIPS QUAGLIATA; Fiscal Year: 1993
    ..5) To establish whether the receptor plays a physiological role in the function of the cells...
  48. IGA FC RECEPTORS
    JULIA PHILLIPS QUAGLIATA; Fiscal Year: 1992
    ..5) To establish whether the receptor plays a physiological role in the function of the cells...
  49. Fc receptors in asthma pathogenesis
    Raphael Clynes; Fiscal Year: 2001
    Description (provided by applicant): Fc receptors, expressed on both professional antigen presenting cells (APCs) and myeloid effector cells, link the humoral and cellular arms at two key regulated steps in the host hypersensitive immune ..
  50. PROSTATE ANTIGENS/Fc RECEPTORS AND TUMOR IMMUNITY
    Paul Wallace; Fiscal Year: 2001
    ..abstract_text> ..
  51. FC RECEPTOR DEPENDENT NEUTROPHIL ACTIVATION
    Elahe Crockett; Fiscal Year: 1991
    ..The effect of CD11/CD18 modulation by various ligands on the function of Fc receptors will also be studied...
  52. FcgRIIb protects fetus from allograft rejection
    CLARK ANDERSON; Fiscal Year: 2009
    ..What function, then, does RIIb serve? One possibility is that villus endothelial Fc receptors serve to trap and eliminate maternal IgG antibodies provoked by and directed toward foreign (paternal) antigen ..
  53. FcgRIIb protects fetus from allograft rejection
    Clark L Anderson; Fiscal Year: 2010
    ..What function, then, does RIIb serve? One possibility is that villus endothelial Fc receptors serve to trap and eliminate maternal IgG antibodies provoked by and directed toward foreign (paternal) antigen ..
  54. FcgRIIb protects fetus from allograft rejection
    CLARK ANDERSON; Fiscal Year: 2009
    ..What function, then, does RIIb serve? One possibility is that villus endothelial Fc receptors serve to trap and eliminate maternal IgG antibodies provoked by and directed toward foreign (paternal) antigen ..
  55. LIGAND BONDING FORCE AND CELL ADHESION BY CD16 ISOFORMS
    Cheng Zhu; Fiscal Year: 1999
    ..The proposed research will contribute to our understanding as to how the membrane anchor of Fc receptors affects their properties, their interactions with ligands, and the ability of such interactions to induce ..
  56. FcgRIIb protects fetus from allograft rejection
    CLARK ANDERSON; Fiscal Year: 2009
    ..What function, then, does RIIb serve? One possibility is that villus endothelial Fc receptors serve to trap and eliminate maternal IgG antibodies provoked by and directed toward foreign (paternal) antigen ..
  57. Ligand Binding Kinetics and Cell Adhesion by Fc Receptor
    Cheng Zhu; Fiscal Year: 2004
    ..It may also provide guidance to the development of Fc-gamma-R- based drugs for treatment of inflammatory disorders and auto-immune diseases. ..
  58. Ligand Binding Kinetics and Cell Adhesion by Fc Receptor
    Cheng Zhu; Fiscal Year: 2003
    ..It may also provide guidance to the development of Fc-gamma-R- based drugs for treatment of inflammatory disorders and auto-immune diseases. ..
  59. Ligand Binding Kinetics and Cell Adhesion by Fc Receptor
    Cheng Zhu; Fiscal Year: 2002
    ..It may also provide guidance to the development of Fc-gamma-R- based drugs for treatment of inflammatory disorders and auto-immune diseases. ..
  60. Ligand Binding Kinetics and Cell Adhesion by Fc Receptor
    Cheng Zhu; Fiscal Year: 2005
    ..It may also provide guidance to the development of Fc-gamma-R- based drugs for treatment of inflammatory disorders and auto-immune diseases. ..
  61. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..These studies will also form a solid foundation for the development of novel decoy Fc?R-based therapies for treatment of AIHA and other antibody-mediated autoimmune disorders in humans. ..
  62. HUMAN NEUTROPHIL RC-RECEPTOR-MEDIATED PHAGOCYTOSIS
    Hattie Gresham; Fiscal Year: 1990
    ..mediators and intracellular enzymes in response to the binding of IgG containing immune complexes to PMN Fc receptors. The transmembrane signals that trigger ingestion of these complexes, lysosomal enzyme release, and/or ..
  63. Development of an anti-PSA IgE to treat prostate cancer
    Birgit Schultes; Fiscal Year: 2009
    ....
  64. HUMAN BLOOD MONOCYTE RECEPTOR EXPRESSION AND MODULATION
    Alan Schreiber; Fiscal Year: 1999
    ..It demonstrates that the mode of signalling and the consequences of receptor ligation via the three Fc receptors (FcgammaRI, II, and III and the receptors' A,B,C isoforms) differs with respect to the roles of Ca++, tyrosine ..
  65. CONTROL OF PERSISTENT ANTIBODY RESPONSE BY FC RECEPTORS
    Timothy Manser; Fiscal Year: 2002
    ..Mice deficient in the activation Fc receptors FcgammaRI and FcgammaRIII display dramatically enhanced IC deposition and retention on FDCs...
  66. CONTROL OF PERSISTENT ANTIBODY RESPONSE BY FC RECEPTORS
    Timothy Manser; Fiscal Year: 1999
    ..Mice deficient in the activation Fc receptors FcgammaRI and FcgammaRIII display dramatically enhanced IC deposition and retention on FDCs...
  67. ANTIGENIC DETERMINANTS OF VARICELLA VIRUS
    Charles Grose; Fiscal Year: 1993
    ....
  68. CONTROL OF PERSISTENT ANTIBODY RESPONSE BY FC RECEPTORS
    Timothy Manser; Fiscal Year: 2000
    ..Mice deficient in the activation Fc receptors FcgammaRI and FcgammaRIII display dramatically enhanced IC deposition and retention on FDCs...
  69. LYMPHOCYTE ACTIVATION BY IMMUNE COMPLEXES
    HAROLD LISCHNER; Fiscal Year: 1980
    ..been shown to be a consequence of interaction of the Fc portion of activated immunoglobulin G molecules with Fc receptors on the surfaces of the active cells...