tumor necrosis factor receptors

Summary

Summary: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.

Top Publications

  1. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
  2. ncbi Synaptic scaling mediated by glial TNF-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Nature 440:1054-9. 2006
  3. ncbi CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    Rebecca S McHugh
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:311-23. 2002
  4. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
  5. ncbi Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    Avi Ashkenazi
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Rev Cancer 2:420-30. 2002
  6. ncbi Apoptosis by death factor
    S Nagata
    Department of Genetics, Osaka University Medical School, Japan
    Cell 88:355-65. 1997
  7. ncbi An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 274:782-4. 1996
  8. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
  9. ncbi Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
    Y Lin
    Department of Cell and Cancer Biology, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 13:2514-26. 1999
  10. ncbi Osteoclast differentiation and activation
    William J Boyle
    Protein Pathways, Inc, Woodland Hills, California 91367, USA
    Nature 423:337-42. 2003

Research Grants

  1. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2003
  2. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2007
  3. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor M Amiji; Fiscal Year: 2010
  4. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2006
  5. Cytoprotective cytokine signaling and reperfusion injury
    Douglas Mann; Fiscal Year: 2009
  6. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
  7. Decoy receptor 3 and liver cirrhosis
    Sunghee Kim; Fiscal Year: 2006
  8. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2006
  9. Biomarkers of Vascular Disease Progression in Type 1 Diabetes Mellitus
    Maria Lopes Virella; Fiscal Year: 2009
  10. Regulation of NF-kB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2003

Detail Information

Publications221 found, 100 shown here

  1. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated...
  2. ncbi Synaptic scaling mediated by glial TNF-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Nature 440:1054-9. 2006
    ..We suggest that by modulating TNF-alpha levels, glia actively participate in the homeostatic activity-dependent regulation of synaptic connectivity...
  3. ncbi CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    Rebecca S McHugh
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:311-23. 2002
    ..Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset...
  4. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
    ..The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation...
  5. ncbi Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    Avi Ashkenazi
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Rev Cancer 2:420-30. 2002
  6. ncbi Apoptosis by death factor
    S Nagata
    Department of Genetics, Osaka University Medical School, Japan
    Cell 88:355-65. 1997
  7. ncbi An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 274:782-4. 1996
    ..These results have implications for the treatment of inflammatory and proliferative diseases...
  8. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
    ..These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity...
  9. ncbi Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
    Y Lin
    Department of Cell and Cancer Biology, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 13:2514-26. 1999
    ..Further more, RIP cleavage was also detected in other death receptor-mediated apoptosis. Therefore, our study provides a potential mechanism to convert cells from life to death in death receptor-mediated apoptosis...
  10. ncbi Osteoclast differentiation and activation
    William J Boyle
    Protein Pathways, Inc, Woodland Hills, California 91367, USA
    Nature 423:337-42. 2003
    ..Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss...
  11. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
    ..These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development...
  12. ncbi BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
    ..These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function...
  13. ncbi Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    H Hsu
    Department of Cell Biology, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Proc Natl Acad Sci U S A 96:3540-5. 1999
    ..These data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteoclast precursor cells...
  14. ncbi An essential role for Scurfin in CD4+CD25+ T regulatory cells
    Roli Khattri
    Celltech R and D Inc, 1631 220th Street SE, Bothell, Washington 98021, USA
    Nat Immunol 4:337-42. 2003
    ..The forced expression of Foxp3 also delays disease in CTLA-4-/- mice, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the T(R) cell lineage...
  15. ncbi The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
    ..However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF-induced cell death and NF-kappa B activation are distinct...
  16. ncbi Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells
    Kuibeom Ko
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Japan
    J Exp Med 202:885-91. 2005
    ..Agonistic anti-GITR mAb is therefore instrumental in treating advanced cancers...
  17. ncbi Apo2L/TRAIL and its death and decoy receptors
    H N LeBlanc
    Department of Molecular Oncology, Genetech, Inc, South San Francisco, CA 94080, USA
    Cell Death Differ 10:66-75. 2003
    ..In this review, we focus on the apoptotic signalling pathways stimulated by Apo2L/TRAIL and summarise what is known about its physiological role...
  18. ncbi LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator
    D N Mauri
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 8:21-30. 1998
    ..This characterizes herpesvirus gD as a membrane-bound viokine and establishes LIGHT-HVEM as integral components of the lymphotoxin cytokine-receptor system...
  19. ncbi Death receptors: signaling and modulation
    A Ashkenazi
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 281:1305-8. 1998
    ..Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery...
  20. ncbi An antagonist decoy receptor and a death domain-containing receptor for TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
    Science 277:815-8. 1997
    ..Another death domain-containing receptor for TRAIL (designated as death receptor-5), which preferentially engaged a FLICE (caspase-8)-related death protease, was also identified...
  21. ncbi Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute Karolinska Hospital, Stockholm 17176, Sweden
    Lancet 363:675-81. 2004
    ..We aimed to assess combination treatment with etanercept and methotrexate versus the monotherapies in patients with rheumatoid arthritis...
  22. ncbi Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
    R I Montgomery
    Northwestern University Medical School, Department of Microbiology Immunology, Chicago, Illinois 60611, USA
    Cell 87:427-36. 1996
    ..The contribution of HVEM to HSV entry into human cells was demonstrable in activated T cells. HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family...
  23. ncbi Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia
    J M Dopp
    Department of Neurology, UCLA 90095, USA
    J Neuroimmunol 75:104-12. 1997
    ..Different patterns of TNFR expression by glia at sites of CNS inflammation may be critical in determining whether TNF has activational, proliferative, or cytotoxic effects on these cells...
  24. ncbi Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Endocr Rev 20:345-57. 1999
    ....
  25. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  26. ncbi Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    H Yasuda
    Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, 519 Ishibashi machi, Shimotsuga gun, Tochigi 329 0512, Japan
    Proc Natl Acad Sci U S A 95:3597-602. 1998
    ..ODF was found to be identical to TRANCE/RANKL, which enhances T-cell growth and dendritic-cell function. ODF seems to be an important regulator in not only osteoclastogenesis but also immune system...
  27. ncbi Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Immunity 2:561-72. 1995
    ..TNF alpha and the 55 kDa TNF receptor are necessary conditions for protection against murine M. tuberculosis infection, but are not solely responsible for the tissue damage observed...
  28. ncbi Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes
    Long Jin
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Invest Dermatol 122:1175-9. 2004
    ..Because RANTES has been implicated in inflammation, TWEAK/Fn14 interaction in human keratinocytes may be involved in the pathophysiology of inflammatory skin disorders...
  29. ncbi Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
    M F McDermott
    Medical Unit, St Bartholomew s and The Royal London Hospital School of Medicine and Dentistry, Whitechapel, London, England
    Cell 97:133-44. 1999
    ..TNFR1-associated periodic syndromes (TRAPS) establish an important class of mutations in TNF receptors. Detailed analysis of one such mutation suggests impaired cytokine receptor clearance as a novel mechanism of disease...
  30. ncbi TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor
    Steven R Wiley
    Amgen Corporation, Seattle, WA 98101, USA
    Cytokine Growth Factor Rev 14:241-9. 2003
    ..Although these studies have contributed a significant amount of new information, numerous questions still remain regarding the role of TWEAK in both normal physiology and the pathogenesis of human disease...
  31. ncbi Efficacy and safety of combination etanercept and methotrexate versus etanercept alone in patients with rheumatoid arthritis with an inadequate response to methotrexate: the ADORE study
    P L C M van Riel
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands
    Ann Rheum Dis 65:1478-83. 2006
    ..The response was defined by the presence of Disease Activity Score-28 joint count (DAS28) >or=3.2 or a combination of >or=5 swollen joints, >or=5 painful joints and erythrocyte sedimentation rate >or=10 mm/h.)..
  32. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
    ..These results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology...
  33. ncbi Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8
    Mariola Fotin-Mleczek
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Cell Sci 115:2757-70. 2002
    ..Hence, TNF-R2 triggering can interfere with TNF-R1-induced apoptosis by inhibition of NF-kappaB-dependent production of anti-apoptotic factors and by blocking the action of anti-apoptotic factors at the post-transcriptional level...
  34. ncbi Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4
    Kim Newton
    Molecular Oncology Department, Genentech, Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 24:1464-9. 2004
    ..Thus, we can exclude RIP3 as an essential modulator of NF-kappa B signaling downstream of several receptor systems...
  35. ncbi TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
    B R Wong
    Laboratory of Immunology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 4:1041-9. 1999
    ..These results define a mechanism by which TRANCE activates Src family kinases and PKB and provide evidence of cross-talk between TRAF proteins and Src family kinases...
  36. ncbi TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
    J Cell Biol 182:171-84. 2008
    ..Lysosomal degradation of cIAP1-TRAF2 by TWEAK/FN14 therefore critically alters the balance of life/death signals emanating from TNF-R1 in immortalized cells...
  37. ncbi CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
    Ann E Herman
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    J Exp Med 199:1479-89. 2004
    ..Thus, CD4+CD25+69- Tregs operate directly in the autoimmune lesion and are dependent on ICOS to keep it in a nondestructive state...
  38. ncbi Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB
    Xuezhong Yang
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 63:1122-9. 2003
    ..Furthermore, we have found that we can improve TRAIL sensitivity in NB by reconstituting caspase 8 with IFN-gamma and TR2 with chemotherapeutic agents...
  39. ncbi TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease
    Linda C Burkly
    Department of Immunobiology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    Cytokine 40:1-16. 2007
    ..In addition to a perspective of the biology, we discuss potential therapeutic strategies targeting this pathway for the treatment of tissue injury, chronic inflammatory diseases and cancer...
  40. ncbi Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes
    Michael Karpusas
    Biogen, Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Mol Biol 315:1145-54. 2002
    ..Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D-E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA, TACI and BAFF-R...
  41. ncbi Expression and function of OX40 ligand on human dendritic cells
    Y Ohshima
    University of Montreal, Centre de Recherche Louis Charles Simard, Notre Dame Hospital, Quebec, Canada
    J Immunol 159:3838-48. 1997
    ..Thus, the expression of OX40L on DC suggests a physiologic role of this molecule during T cell priming by virtue of its ability to costimulate both T cell and DC activation and differentiation...
  42. ncbi osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
    ....
  43. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001
    ..In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA...
  44. ncbi Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5
    N Mitsiades
    National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 61:2704-12. 2001
    ....
  45. ncbi Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Neurochem 96:706-18. 2006
    ..These findings support the hypothesis that TNF-alpha may play a role in the selective vulnerability of the nigrostriatal pathway associated with dopaminergic neurotoxicity and perhaps Parkinson's disease...
  46. ncbi Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death
    Georgios V Georgakis
    Department of Lymphoma/Myeloma, M.D. Anderson Cancer Center (MDACC, Houston, TX 77030, USA
    Br J Haematol 130:501-10. 2005
    ..Our data demonstrate that HGS-ETR1 and HGS-ETR2 monoclonal antibodies can induce cell death in a variety of cultured and primary lymphoma cells, and may have therapeutic value in lymphoma...
  47. ncbi Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine and the Houston VA, Houston, Tex 77030, USA
    Circulation 109:1594-602. 2004
    ..Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure...
  48. ncbi Role of SODD in regulation of tumor necrosis factor responses
    Hidetoshi Takada
    Advanced Medical Discovery Institute, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    Mol Cell Biol 23:4026-33. 2003
    ..Interestingly, the apoptotic arm of TNF signaling is not hyperresponsive in the SODD-deficient cells. Together, these results suggest that SODD is critical for the regulation of TNF signaling...
  49. ncbi Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor
    W R Godfrey
    Department of Pathology, Stanford University School of Medicine, California 94305
    J Exp Med 180:757-62. 1994
    ..We describe gp34 as a new member of the TNF family, and find that the recombinant ligand expressed in COS cells costimulates phorbol myristate acetate, phytohemagglutinin, and anti-CD3-induced CD4+ T cell proliferation...
  50. ncbi Control of synaptic strength by glial TNFalpha
    Eric C Beattie
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Science 295:2282-5. 2002
    ..Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury...
  51. ncbi The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
    Arthritis Rheum 50:2750-6. 2004
    ..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...
  52. ncbi Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis
    Helmut Franck
    Center of Rheumatology, Oberammergau and the Department of Gastroenterology, Endocrinology and Metabolism, Philipps-University, Marburg, Germany
    J Rheumatol 31:2236-41. 2004
    ....
  53. ncbi Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat
    M Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Neurosci Lett 347:179-82. 2003
    ..TNFR upregulation in injured and adjacent uninjured DRG neurons may be essential for mediating enhanced TNF effects and thus contribute to the development of pain-related behavior...
  54. ncbi Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses
    I Gramaglia
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 161:6510-7. 1998
    ..These data suggest that Ox-40/Ox-40L interactions act after initial activation events to prolong clonal expansion and enhance effector cytokine secretion, and may be involved in promoting long-lived primary CD4 responses...
  55. ncbi Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
    R M Pitti
    Department of Molecular Oncology, Molecular Biology, and Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 396:699-703. 1998
    ..Thus, certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL...
  56. ncbi Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:7724-31. 1999
    ....
  57. ncbi BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Australia
    J Clin Invest 112:286-97. 2003
    ..These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases...
  58. ncbi TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor
    Tara C Polek
    Department of Bioimmunotherapy, Section of Cytokine Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:32317-23. 2003
    ..We propose that the biological effects of TWEAK are mediated by binding to one of at least two distinct receptors that induce differential activation of downstream signaling pathways...
  59. ncbi Tumor necrosis factor receptor and Fas signaling mechanisms
    D Wallach
    Department of Biological Chemistry, Weizmann Institute, Rehovot, Israel
    Annu Rev Immunol 17:331-67. 1999
    ....
  60. ncbi Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
    Kazuo Sugamura
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan
    Nat Rev Immunol 4:420-31. 2004
  61. ncbi Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
    Y Yamada
    Department of Pathology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 94:1441-6. 1997
    ..The results indicate that TNF, signaling through the TNFR-I, can initiate liver regeneration and acts by activating an interleukin 6-dependent pathway that involves the STAT3 transcription factor...
  62. ncbi The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract
    M S Sheikh
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncogene 18:4153-9. 1999
    ..It is, therefore, possible that TRID overexpressing GIT tumors may gain a selective growth advantage by escaping from TRAIL-induced apoptosis...
  63. ncbi NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    O N Ozes
    Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, Indianapolis 46202, USA
    Nature 401:82-5. 1999
    ..Mutation of this amino acid blocks phosphorylation by Akt or TNF and activation of NF-kappaB. These findings indicate that Akt is part of a signalling pathway that is necessary for inducing key immune and inflammatory responses...
  64. ncbi Etanercept, infliximab, and leflunomide in established rheumatoid arthritis: clinical experience using a structured follow up programme in southern Sweden
    P Geborek
    Department of Rheumatology, Lund University Hospital, S 221 85 Lund, Sweden
    Ann Rheum Dis 61:793-8. 2002
    ....
  65. ncbi Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop
    Clarissa von Haefen
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, University of Berlin, Germany
    Oncogene 22:2236-47. 2003
    ..In addition, this is the first report to demonstrate death receptor-independent caspase-8 autoprocessing in vivo...
  66. ncbi Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    FASEB J 20:670-82. 2006
    ..Taken together, our results are indicative of a region-specific and dual role for TNF-alpha in the brain: a promoter of neurodegeneration in striatum and a protector against neurodegeneration in hippocampus...
  67. ncbi Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway
    Lara Marchetti
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, D 70569 Stuttgart, Germany
    J Biol Chem 279:32869-81. 2004
    ..Thus, the duration of NF-kappa B activation is a critical determinant for sensitivity toward excitotoxic stress and is dependent on a differential upstream signal pathway usage of the two TNFRs...
  68. ncbi Epstein-Barr virus immediate-early protein BZLF1 inhibits tumor necrosis factor alpha-induced signaling and apoptosis by downregulating tumor necrosis factor receptor 1
    Thomas E Morrison
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Virol 78:544-9. 2004
    ..Thus, EBV has developed a novel mechanism for evading TNF-alpha antiviral effects during lytic reactivation or primary infection...
  69. ncbi Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo
    V Mohamed-Ali
    Centre for Diabetes and Cardiovascular Risk, University College London Medical School, London N19 3UA, United Kingdom
    Am J Physiol 277:E971-5. 1999
    ....
  70. ncbi Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8
    F C Kischkel
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 276:46639-46. 2001
    ..Thus, apoptosis signaling by death receptors involves not only caspase-8 but also caspase-10, and both caspases may have equally important roles in apoptosis initiation...
  71. ncbi Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis
    Mathula Thangarajh
    Neurotec Department, Division of Neurology R54, Karolinska Institutet at Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    J Neuroimmunol 152:183-90. 2004
    ..In addition, each MS disease course was associated with a unique expression pattern for all four molecules...
  72. ncbi Tumor necrosis factor signaling
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring, Germany
    Cell Death Differ 10:45-65. 2003
    ..In particular, the multiple facets of crosstalk between the various signalling pathways engaged by TNF will be addressed...
  73. ncbi Cell surface Death Receptor signaling in normal and cancer cells
    Nesrin Ozören
    Department of Medicine, University of Pennsylvania School of Medicine, CRB 437A, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Semin Cancer Biol 13:135-47. 2003
    ..FLIP and BCL-XL expression may reduce sensitivity of cancer cells to combination therapies...
  74. ncbi Modulation of T-cell responses to alloantigens by TR6/DcR3
    J Zhang
    Human Genome Sciences Inc, Rockville, Maryland, USA
    J Clin Invest 107:1459-68. 2001
    ..Such regulatory effects of TR6 probably occur via interference with interaction between pairs of related TNF and TNFR family members, LIGHT/TR2 being one of the possible candidate pairs...
  75. ncbi TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity
    Patrick J Donohue
    Department of Vascular Biology, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Arterioscler Thromb Vasc Biol 23:594-600. 2003
    ..TWEAK can also enhance both FGF-2 and VEGF-A mitogenic activity on ECs. Thus, TWEAK may act alone as well as in combination with FGF-2 or VEGF-A to regulate pathological angiogenesis...
  76. ncbi NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily
    G U von Bülow
    Department of Experimental Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Science 278:138-41. 1997
    ..TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate...
  77. ncbi A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses
    Francis Ka Ming Chan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:51613-21. 2003
    ..Thus, TNF-induced programmed necrosis is facilitated by TNFR-2 signaling and caspase inhibition and may play a role in controlling viral infection...
  78. ncbi High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment
    Maria Ziolkowska
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    Arthritis Rheum 46:1744-53. 2002
    ....
  79. ncbi B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses
    S Xu
    Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    Mol Cell Biol 21:4067-74. 2001
    ..These data suggest a functional redundancy of BCMA in B-cell physiology that is probably due to the presence of TACI, another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL...
  80. ncbi Molecular mechanisms of promoter regulation of the gp34 gene that is trans-activated by an oncoprotein Tax of human T cell leukemia virus type I
    K Ohtani
    Human Gene Sciences Center, Japan
    J Biol Chem 273:14119-29. 1998
    ..Our results imply complex regulation of expression of the gp34 gene and suggest implication of gp34 in proliferation of HTLV-I infected T cells...
  81. ncbi Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand
    Alexander Kotelkin
    Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:9156-72. 2003
    ....
  82. ncbi The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    David L Boone
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
    Nat Immunol 5:1052-60. 2004
    ..The critical function of this deubiquitinating enzyme in the restriction of TLR signals emphasizes the importance of the regulation of ubiquitin conjugation in innate immune cells...
  83. ncbi Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
    Susumu Nakata
    Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramcahi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
    Oncogene 23:6261-71. 2004
    ..These results suggest that this combined treatment with HDACIs and TRAIL is a promising strategy for new cancer therapeutics...
  84. ncbi BAFF: a fundamental survival factor for B cells
    Fabienne Mackay
    Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Nat Rev Immunol 2:465-75. 2002
    ..The elucidation of the role of BAFF has set the stage for a new approach to the treatment of autoimmune disease...
  85. ncbi Activation and accumulation of B cells in TACI-deficient mice
    M Yan
    Department of Molecular Oncology, Genentech Inc, San Francisco, CA 94080, USA
    Nat Immunol 2:638-43. 2001
    ..In vivo antigen challenge resulted in enhanced antigen-specific antibody production. Thus, TACI may play an unexpected inhibitory role in B cell activation that helps maintain immunological homeostasis...
  86. ncbi Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury
    P G Sullivan
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neurosci 19:6248-56. 1999
    ..Analysis of NF-kappaB activation and relative levels of MnSOD revealed delayed responses in the injured cortex of TNFR-KO animals compared with wild-type animals, implying that endogenous TNFalpha may be neuroprotective after TBI...
  87. ncbi Baseline factors that influence ASAS 20 response in patients with ankylosing spondylitis treated with etanercept
    John C Davis
    Division of Rheumatology, University of California, San Francisco 94143 0633, USA
    J Rheumatol 32:1751-4. 2005
    ..To examine the baseline demographic and disease characteristics that might influence improvement as measured by the Assessment in Ankylosing Spondylitis Response Criteria (ASAS 20) in patients with ankylosing spondylitis (AS)...
  88. ncbi Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL
    M MacFarlane
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 272:25417-20. 1997
    ..Thus, TRAIL receptor-3 may function as an antagonistic decoy receptor to attenuate the cytotoxic effect of TRAIL in most tissues that are TRAIL+, DR4+, and DR5+...
  89. ncbi Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation
    S R Ruuls
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 15:533-43. 2001
    ..We conclude that memTNF supports many processes underlying lymphoid tissue structure, but secreted TNF is needed for optimal inflammatory lesion development...
  90. ncbi Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury
    Albert Quintana
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Sciences, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
    J Neurosci Res 82:701-16. 2005
    ..Overall, these results suggest that TNFR1 is involved in the early establishment of the inflammatory response and that its deficiency causes a decreased inflammatory response and tissue damage following brain injury...
  91. ncbi Lack of efficacy of etanercept in Sjögren syndrome correlates with failed suppression of tumour necrosis factor alpha and systemic immune activation
    N M Moutsopoulos
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann Rheum Dis 67:1437-43. 2008
    ....
  92. ncbi Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells
    Jie Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 283:19665-77. 2008
    ....
  93. ncbi Host defense, viruses and apoptosis
    G N Barber
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, FL 33136, USA
    Cell Death Differ 8:113-26. 2001
    ..This likelihood is additionally underlined by the elaborate strategies developed by viruses to inhibit IFN-antiviral function and the mechanisms of cell death...
  94. ncbi Osteoprotegerin (OPG) acts as an endogenous decoy receptor in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells
    T Miyashita
    The First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Clin Exp Immunol 137:430-6. 2004
    ..In addition, IL-1beta seems to promote the growth of rheumatoid synovial tissues through stimulation of OPG production, which interferes with TRAIL death signals in a competitive manner...
  95. ncbi Sensitivity of prostate cells to TRAIL-induced apoptosis increases with tumor progression: DR5 and caspase 8 are key players
    Vincent Hesry
    GERHM INSERM U625, IFR140 GFAS, Universite de Rennes I, Rennes Cedex, France
    Prostate 66:987-95. 2006
    ....
  96. ncbi A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory response
    Dhaya Seshasayee
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 279:30202-9. 2004
    ..Thus, our study strongly suggests that administration of receptor fusion proteins to specifically block OPGL activity in vivo may result in blocking development of monocyte/macrophage-mediated diseases...
  97. ncbi Mechanical stress induces expression of cytokines in human periodontal ligament cells
    T Yamamoto
    Department of Dental Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Oral Dis 12:171-5. 2006
    ..Although the role of cytokines in hPDL function is not clearly understood, we investigated the effect of mechanical stress as hydrostatic pressure (HP) on cytokine expression in hPDL cells...
  98. ncbi Maturation-state dependent response of human periodontal ligament cells to an intermittent parathyroid hormone exposure in vitro
    S Lossdörfer
    Department of Orthodontics, Dental Clinic, University of Bonn, Bonn, Germany
    J Periodontal Res 41:62-72. 2006
    ....
  99. ncbi A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss
    Kazuhiro Aoki
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8044, USA
    J Clin Invest 116:1525-34. 2006
    ..These results suggest that a peptide that mimics a TNFR ligand contact site blocks bone resorption by interfering with recruitment and activation of osteoclasts by both RANKL and TNF...
  100. ncbi Tumor necrosis factor-alpha: alternative role as an inhibitor of osteoclast formation in vitro
    Renate Balga
    Group for Bone Biology, Department Clinical Research, University of Berne, Murtenstrasse 35, CH 3010 Berne, Switzerland
    Bone 39:325-35. 2006
    ....
  101. ncbi Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically
    Jane L Fisher
    St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy 3065, Victoria, Australia
    Cancer Res 66:3620-8. 2006
    ....

Research Grants81

  1. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2003
    ..abstract_text> ..
  2. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2007
    ..abstract_text> ..
  3. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor M Amiji; Fiscal Year: 2010
    ..In addition, NiMOS would be useful for other oral gene therapy strategies for treatment of diseases or oral DNA vaccination. ..
  4. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2006
    ..abstract_text> ..
  5. Cytoprotective cytokine signaling and reperfusion injury
    Douglas Mann; Fiscal Year: 2009
    ....
  6. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ....
  7. Decoy receptor 3 and liver cirrhosis
    Sunghee Kim; Fiscal Year: 2006
    ....
  8. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2006
    ..3). To determine whether overexpression of Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) in mouse lung exacerbates silica- induced lung injury. ..
  9. Biomarkers of Vascular Disease Progression in Type 1 Diabetes Mellitus
    Maria Lopes Virella; Fiscal Year: 2009
    ..Competitive Revision to measure VCAM-1, ICAM-1, E-selectin, PAI-1, fibrinogen, CRP, IL-6, and soluble tumor necrosis factor receptors in these samples...
  10. Regulation of NF-kB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2003
    ..abstract_text> ..
  11. Redox Mechanisms of Ischemia Reperfusion Injury in the Liver
    John F Engelhardt; Fiscal Year: 2010
    ..e., stroke and cardiac infarct), hence, the proposed research may also enhance of our understanding of ischemic injuries in other organs. ..
  12. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2006
    ..abstract_text> ..
  13. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2007
    ..abstract_text> ..
  14. Soluble Decoy Receptor 3 in Bacterial Infection and Sepsis
    Sunghee Kim; Fiscal Year: 2006
    ....
  15. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  16. Respiratory Muscle Weakness in Chronic Inflammation
    Michael B Reid; Fiscal Year: 2010
    ..The goal of this project is to identify new therapies that preserve respiratory muscle function in order to lessen illness and prolong life. ..
  17. ADPKD: Understanding mechanisms, Discovering treatments.
    Xiaogang Li; Fiscal Year: 2010
    ..The information from our studies will be likely to open new avenues in the research of ADPKD and establish the foundation for developing effective therapies of the disease. ..
  18. Regulation of lymphocyte survival by NF-kB proteins
    Amer Beg; Fiscal Year: 2004
    ..These studies may also provide insights into development of strategies for enhancing lymphopoiesis under therapeutic settings. ..
  19. Role of NF-kB activation in acute allograft rejection
    Maria Luisa Alegre; Fiscal Year: 2010
    ..In this application we propose to investigate the mechanisms by which TCR-CARMA1-NF-?B regulates formation of nTregs, iTregs and Th17 cells and how these effects impact allograft fate. ..
  20. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2006
    ....
  21. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Low density lipoprotein receptor-related protein has emerged as an important regulator of inflammation and atherosclerosis. This proposal seeks to elucidate the responsible mechanisms. ..
  22. Targeting GITR for Tumor Immunotherapy
    Adam Cohen; Fiscal Year: 2007
    ..Gaining greater mechanistic understanding of the effects of anti-GITR antibody on tumor immunity will allow for more rational translation of this promising immunotherapeutic approach to the clinic. ..
  23. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Development of highly specific imaging agents for noninvasive detection of inflammation induced by heart attacks. ..
  24. Herpes simplex virus receptors and signal transduction
    PATRICIA SPEAR; Fiscal Year: 2003
    ..The studies described in this proposal are distinct from those supported by the parent grant but address questions that arise from findings made in the parent project. ..
  25. Cell-Based Assays for Identifying Anti-RANK Signaling Agents
    Xu Feng; Fiscal Year: 2007
    ....
  26. Brain Endothelial TNF-R1 Can Function to Inhibit Angiogenesis
    Candece L Gladson; Fiscal Year: 2010
    ..This approach would be a significant advance over the therapies currently being tested that retard the growth of the blood vessels, but do not eliminate them. ..
  27. Regulation of Type 2 NF-kappaB Activation and Inflammation
    Genhong Cheng; Fiscal Year: 2009
    ..Elucidating the molecular mechanisms responsible for inhibiting NF-kB activity will undoubtedly help in designing novel strategies to treat human diseases associated overactivation of NF-kB. ..
  28. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2005
    ....
  29. Regulation of Type 2 NF-kappaB Activation and Inflammation
    Genhong Cheng; Fiscal Year: 2010
    ..Elucidating the molecular mechanisms responsible for inhibiting NF-kB activity will undoubtedly help in designing novel strategies to treat human diseases associated overactivation of NF-kB. ..