tumor necrosis factor receptors

Summary

Summary: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.

Top Publications

  1. ncbi Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    Avi Ashkenazi
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Rev Cancer 2:420-30. 2002
  2. pmc Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    H Hsu
    Department of Cell Biology, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Proc Natl Acad Sci U S A 96:3540-5. 1999
  3. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
  4. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
  5. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
  6. pmc Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    H Yasuda
    Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, 519 Ishibashi machi, Shimotsuga gun, Tochigi 329 0512, Japan
    Proc Natl Acad Sci U S A 95:3597-602. 1998
  7. ncbi Apoptosis by death factor
    S Nagata
    Department of Genetics, Osaka University Medical School, Japan
    Cell 88:355-65. 1997
  8. ncbi A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    D M Anderson
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    Nature 390:175-9. 1997
  9. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
  10. ncbi Synaptic scaling mediated by glial TNF-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Nature 440:1054-9. 2006

Detail Information

Publications253 found, 100 shown here

  1. ncbi Targeting death and decoy receptors of the tumour-necrosis factor superfamily
    Avi Ashkenazi
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Rev Cancer 2:420-30. 2002
  2. pmc Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    H Hsu
    Department of Cell Biology, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Proc Natl Acad Sci U S A 96:3540-5. 1999
    ..These data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteoclast precursor cells...
  3. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated...
  4. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  5. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
    ..The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation...
  6. pmc Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    H Yasuda
    Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, 519 Ishibashi machi, Shimotsuga gun, Tochigi 329 0512, Japan
    Proc Natl Acad Sci U S A 95:3597-602. 1998
    ..ODF was found to be identical to TRANCE/RANKL, which enhances T-cell growth and dendritic-cell function. ODF seems to be an important regulator in not only osteoclastogenesis but also immune system...
  7. ncbi Apoptosis by death factor
    S Nagata
    Department of Genetics, Osaka University Medical School, Japan
    Cell 88:355-65. 1997
  8. ncbi A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    D M Anderson
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    Nature 390:175-9. 1997
    ..Thus RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells...
  9. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
    ..These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity...
  10. ncbi Synaptic scaling mediated by glial TNF-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Nature 440:1054-9. 2006
    ..We suggest that by modulating TNF-alpha levels, glia actively participate in the homeostatic activity-dependent regulation of synaptic connectivity...
  11. pmc RANK is essential for osteoclast and lymph node development
    W C Dougall
    Immunex Corporation, Seattle, Washington 98101 USA
    Genes Dev 13:2412-24. 1999
    ..These experiments reveal that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation...
  12. pmc BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
    ..These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function...
  13. ncbi Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
    J P Sheridan
    Department of Molecular Oncology, Genentech, South San Francisco, CA 94080 4918, USA
    Science 277:818-21. 1997
    ..DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli...
  14. ncbi The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
    ..However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF-induced cell death and NF-kappa B activation are distinct...
  15. ncbi An antagonist decoy receptor and a death domain-containing receptor for TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
    Science 277:815-8. 1997
    ..Another death domain-containing receptor for TRAIL (designated as death receptor-5), which preferentially engaged a FLICE (caspase-8)-related death protease, was also identified...
  16. ncbi Death receptors: signaling and modulation
    A Ashkenazi
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 281:1305-8. 1998
    ..Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery...
  17. ncbi OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells
    P R Rogers
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunity 15:445-55. 2001
    ..Moreover, retroviral transduction of OX40-/- T cells with Bcl-xL or Bcl-2 reverses their survival defect. Thus, a temporal relationship exists between CD28 and OX40, with OX40 being a critical regulator of antigen-driven T cell survival...
  18. ncbi An essential role for Scurfin in CD4+CD25+ T regulatory cells
    Roli Khattri
    Celltech R and D Inc, 1631 220th Street SE, Bothell, Washington 98021, USA
    Nat Immunol 4:337-42. 2003
    ..The forced expression of Foxp3 also delays disease in CTLA-4-/- mice, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the T(R) cell lineage...
  19. ncbi The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion
    I Gramaglia
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 165:3043-50. 2000
    ..In this way, OX40 signals promote survival of greater numbers of T cells with time and control the size of the memory T cell pool...
  20. ncbi Tumor necrosis factor signaling
    H Wajant
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring, Germany
    Cell Death Differ 10:45-65. 2003
    ..In particular, the multiple facets of crosstalk between the various signalling pathways engaged by TNF will be addressed...
  21. ncbi Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Immunity 2:561-72. 1995
    ..TNF alpha and the 55 kDa TNF receptor are necessary conditions for protection against murine M. tuberculosis infection, but are not solely responsible for the tissue damage observed...
  22. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
    ..These results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology...
  23. ncbi The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
    G Mosialos
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
    Cell 80:389-99. 1995
    ..The interaction of LMP1 with these TNFR family-associated proteins is further evidence for their role in signaling and links LMP1-mediated transformation to signal transduction from the TNFR family...
  24. ncbi Osteoclast differentiation and activation
    William J Boyle
    Protein Pathways, Inc, Woodland Hills, California 91367, USA
    Nature 423:337-42. 2003
    ..Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss...
  25. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
    ..These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development...
  26. ncbi GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations
    Simona Ronchetti
    Eur J Immunol 34:613-22. 2004
    ..These results indicate a novel function for GITR as costimulatory molecule of T cell subsets...
  27. ncbi TWEAK attenuates the transition from innate to adaptive immunity
    Heather Maecker
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cell 123:931-44. 2005
    ..Thus, TWEAK suppresses production of IFN-gamma and IL-12, curtailing the innate response and its transition to adaptive TH1 immunity...
  28. ncbi Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute Karolinska Hospital, Stockholm 17176, Sweden
    Lancet 363:675-81. 2004
    ..We aimed to assess combination treatment with etanercept and methotrexate versus the monotherapies in patients with rheumatoid arthritis...
  29. ncbi Apo2L/TRAIL and its death and decoy receptors
    H N LeBlanc
    Department of Molecular Oncology, Genetech, Inc, South San Francisco, CA 94080, USA
    Cell Death Differ 10:66-75. 2003
    ..In this review, we focus on the apoptotic signalling pathways stimulated by Apo2L/TRAIL and summarise what is known about its physiological role...
  30. ncbi LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator
    D N Mauri
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 8:21-30. 1998
    ..This characterizes herpesvirus gD as a membrane-bound viokine and establishes LIGHT-HVEM as integral components of the lymphotoxin cytokine-receptor system...
  31. ncbi Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
    R I Montgomery
    Northwestern University Medical School, Department of Microbiology Immunology, Chicago, Illinois 60611, USA
    Cell 87:427-36. 1996
    ..The contribution of HVEM to HSV entry into human cells was demonstrable in activated T cells. HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family...
  32. ncbi The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor
    B R Wong
    Laboratory of Immunology, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:28355-9. 1998
    ..Furthermore, transfection experiments with TRANCE-R deletion mutants revealed that multiple regions of the TRANCE-R can mediate NF-kappaB activation...
  33. ncbi FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
    M R Sprick
    Tumor Immunology Program, German Cancer Research Center DKFZ Heidelberg
    Immunity 12:599-609. 2000
    ..FADD/MORT1- and caspase-8-deficient Jurkat cells expressing only TRAIL-R2 were resistant to TRAIL-induced apoptosis. Thus, FADD/MORT1 and caspase-8 are essential for apoptosis induction via TRAIL-R2...
  34. ncbi Tumor necrosis factor receptor and Fas signaling mechanisms
    D Wallach
    Department of Biological Chemistry, Weizmann Institute, Rehovot, Israel
    Annu Rev Immunol 17:331-67. 1999
    ....
  35. ncbi TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
    B R Wong
    The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 272:25190-4. 1997
    ..These results suggest a role for this TNF-related ligand in the regulation of the T cell-dependent immune response...
  36. pmc Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
    M A Degli-Esposti
    Department of Biochemistry and the Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 186:1165-70. 1997
    ..Moreover, unlike TRAIL-R1 and -R2, in a transient overexpression system TRAIL-R3 does not induce apoptosis...
  37. ncbi Apoptotic pathways: paper wraps stone blunts scissors
    D R Green
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Cell 102:1-4. 2000
  38. pmc Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells
    Kuibeom Ko
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Japan
    J Exp Med 202:885-91. 2005
    ..Agonistic anti-GITR mAb is therefore instrumental in treating advanced cancers...
  39. pmc The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
    M Grell
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Proc Natl Acad Sci U S A 95:570-5. 1998
    ..In accordance with this reasoning, the lower signaling capability of homotrimeric lymphotoxin, compared with TNF, correlates with a lower stability of the lymphotoxin-TNF-R1 complex at 37 degrees C...
  40. ncbi A novel receptor for Apo2L/TRAIL contains a truncated death domain
    S A Marsters
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080 4918, USA
    Curr Biol 7:1003-6. 1997
    ..Upon overexpression, DcR2 did not activate apoptosis or nuclear factor-kappaB; however, it substantially reduced cellular sensitivity to Apo2L-induced apoptosis. These results suggest that DcR2 functions as an inhibitory Apo2L receptor...
  41. ncbi Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Endocr Rev 20:345-57. 1999
    ....
  42. ncbi Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia
    J M Dopp
    Department of Neurology, UCLA 90095, USA
    J Neuroimmunol 75:104-12. 1997
    ..Different patterns of TNFR expression by glia at sites of CNS inflammation may be critical in determining whether TNF has activational, proliferative, or cytotoxic effects on these cells...
  43. pmc Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
    Y Yamada
    Department of Pathology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 94:1441-6. 1997
    ..The results indicate that TNF, signaling through the TNFR-I, can initiate liver regeneration and acts by activating an interleukin 6-dependent pathway that involves the STAT3 transcription factor...
  44. ncbi Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway
    P M Chaudhary
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Immunity 7:821-30. 1997
    ..Thus, both DR5 and DR4 use FADD, TRADD, and RIP in their signal transduction pathways, and FADD is the common mediator of apoptosis by all known death domain-containing receptors...
  45. ncbi Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis
    G C Suvannavejh
    Department of Microbiology Immunology, Interdepartmental Immunology Center, Northwestern University Medical School, 303 E Chicago Avenue, Illinois 60611, USA
    Cell Immunol 205:24-33. 2000
    ..These results have important implications for therapies targeting p55 and p75 receptors for treating autoimmune diseases...
  46. ncbi Expression and function of OX40 ligand on human dendritic cells
    Y Ohshima
    University of Montreal, Centre de Recherche Louis Charles Simard, Notre Dame Hospital, Quebec, Canada
    J Immunol 159:3838-48. 1997
    ..Thus, the expression of OX40L on DC suggests a physiologic role of this molecule during T cell priming by virtue of its ability to costimulate both T cell and DC activation and differentiation...
  47. ncbi Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
    M Takeuchi
    Yamanouchi Pharmaceutical Co Ltd, Tsukuba, Ibaraki 305, Japan
    J Biol Chem 271:19935-42. 1996
    ..Thus, distinct domains of TRAF2 are involved in recruitment and signaling functions...
  48. pmc TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL
    H Walczak
    Immunex Corporation, 51 University Street, Seattle, WA 98101, USA
    EMBO J 16:5386-97. 1997
    ..The existence of two distinct receptors for the same ligand suggests an unexpected complexity to TRAIL biology, reminiscent of dual receptors for TNF, the canonical member of this family...
  49. pmc A regulatory role for TRAF1 in antigen-induced apoptosis of T cells
    D E Speiser
    Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada
    J Exp Med 185:1777-83. 1997
    ....
  50. ncbi TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
    Xiaoming Li
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nature 416:345-7. 2002
    ..These findings identify a physiologic role for c-IAP1 and define a mechanism by which TNF-RII-regulated ubiquitin protein ligase activity can potentiate TNF-induced apoptosis...
  51. ncbi Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8
    Mariola Fotin-Mleczek
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Cell Sci 115:2757-70. 2002
    ..Hence, TNF-R2 triggering can interfere with TNF-R1-induced apoptosis by inhibition of NF-kappaB-dependent production of anti-apoptotic factors and by blocking the action of anti-apoptotic factors at the post-transcriptional level...
  52. pmc BCMA is essential for the survival of long-lived bone marrow plasma cells
    BRIAN P O'CONNOR
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    J Exp Med 199:91-8. 2004
    ..These findings offer new insights into the molecular basis for the long-term survival of PCs...
  53. ncbi TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor
    Steven R Wiley
    Amgen Corporation, Seattle, WA 98101, USA
    Cytokine Growth Factor Rev 14:241-9. 2003
    ..Although these studies have contributed a significant amount of new information, numerous questions still remain regarding the role of TWEAK in both normal physiology and the pathogenesis of human disease...
  54. pmc Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
    Y Lin
    Department of Cell and Cancer Biology, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 13:2514-26. 1999
    ..Further more, RIP cleavage was also detected in other death receptor-mediated apoptosis. Therefore, our study provides a potential mechanism to convert cells from life to death in death receptor-mediated apoptosis...
  55. ncbi CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    Rebecca S McHugh
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:311-23. 2002
    ..Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset...
  56. ncbi Anti-TNFalpha therapy in rheumatoid arthritis and autoimmunity
    Paola Caramaschi
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Verona, Verona, Italy
    Rheumatol Int 26:209-14. 2006
    ..Both CRP and Blys do not seem to participate in this phenomenon. Other autoantibodies were detected in a few patients, but no case of onset of new autoimmune disorders was observed...
  57. ncbi TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor
    Tara C Polek
    Department of Bioimmunotherapy, Section of Cytokine Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:32317-23. 2003
    ..We propose that the biological effects of TWEAK are mediated by binding to one of at least two distinct receptors that induce differential activation of downstream signaling pathways...
  58. ncbi BAFF: a fundamental survival factor for B cells
    Fabienne Mackay
    Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Nat Rev Immunol 2:465-75. 2002
    ..The elucidation of the role of BAFF has set the stage for a new approach to the treatment of autoimmune disease...
  59. pmc A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure
    Mohit Jain
    Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 119:2058-68. 2009
    ..Although many of the processes and downstream signals regulated by the TWEAK/Fn14 pathway have been implicated in the development of cardiac dysfunction, the role of TWEAK in the cardiovascular system is completely unknown...
  60. ncbi Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction
    Jagan R Muppidi
    Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 21:461-5. 2004
    ..Here, we discuss how receptor submembrane localization and the formation of alternate signaling complexes can alter the fate of cells stimulated through TNFRs with a death domain, also known as "death receptors."..
  61. ncbi Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis
    Hillarie L Plessner
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Infect Dis 195:1643-50. 2007
    ..These findings begin to clarify the mechanistic difference between anti-TNF agents and their role in the exacerbation of tuberculosis...
  62. ncbi TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    J J Peschon
    Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 160:943-52. 1998
    ..In summary, these data help clarify the biologic roles of p55 and p75 in mediating and modulating the biologic activity of TNF and provide genetic evidence for an antagonistic role of p75 in vivo...
  63. ncbi An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 274:782-4. 1996
    ..These results have implications for the treatment of inflammatory and proliferative diseases...
  64. ncbi Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulation
    Milada Mahic
    Biotechnology Centre and Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, Norway
    Eur J Immunol 38:640-6. 2008
    ..However, neither blocking antibodies to CTLA-4, CD80 nor CD86 could reverse CD8(+) T(R)-mediated suppression, indicating that other mechanism(s) must be employed by these cells...
  65. pmc TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
    J Cell Biol 182:171-84. 2008
    ..Lysosomal degradation of cIAP1-TRAF2 by TWEAK/FN14 therefore critically alters the balance of life/death signals emanating from TNF-R1 in immortalized cells...
  66. ncbi Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes
    Long Jin
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Invest Dermatol 122:1175-9. 2004
    ..Because RANTES has been implicated in inflammation, TWEAK/Fn14 interaction in human keratinocytes may be involved in the pathophysiology of inflammatory skin disorders...
  67. pmc Efficacy and safety of combination etanercept and methotrexate versus etanercept alone in patients with rheumatoid arthritis with an inadequate response to methotrexate: the ADORE study
    P L C M van Riel
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands
    Ann Rheum Dis 65:1478-83. 2006
    ..The response was defined by the presence of Disease Activity Score-28 joint count (DAS28) >or=3.2 or a combination of >or=5 swollen joints, >or=5 painful joints and erythrocyte sedimentation rate >or=10 mm/h.)..
  68. ncbi Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
    M F McDermott
    Medical Unit, St Bartholomew s and The Royal London Hospital School of Medicine and Dentistry, Whitechapel, London, England
    Cell 97:133-44. 1999
    ..TNFR1-associated periodic syndromes (TRAPS) establish an important class of mutations in TNF receptors. Detailed analysis of one such mutation suggests impaired cytokine receptor clearance as a novel mechanism of disease...
  69. pmc Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4
    Kim Newton
    Molecular Oncology Department, Genentech, Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 24:1464-9. 2004
    ..Thus, we can exclude RIP3 as an essential modulator of NF-kappa B signaling downstream of several receptor systems...
  70. ncbi Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells
    Norihiro Harada
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 299:488-93. 2002
    ..These results indicated that TWEAK could induce pro-inflammatory reactions via Fn14 on HUVEC...
  71. ncbi B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
    Lai Guan Ng
    Arthritis and Asthma Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Immunol 173:807-17. 2004
    ..Thus, BAFF-R is important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells...
  72. pmc Tumor necrosis factor-alpha mediates orthopedic implant osteolysis
    K D Merkel
    Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Pathol 154:203-10. 1999
    ..Finally, the protective effect of deletion of both TNF receptors is recapitulated in mice lacking only the p55 receptor. Thus, targeting TNF and/or its p55 receptor may arrest wear particle osteolysis...
  73. ncbi The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    David L Boone
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
    Nat Immunol 5:1052-60. 2004
    ..The critical function of this deubiquitinating enzyme in the restriction of TLR signals emphasizes the importance of the regulation of ubiquitin conjugation in innate immune cells...
  74. ncbi Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:7724-31. 1999
    ....
  75. ncbi Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B
    I K Jang
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202 5120, USA
    Biochem Biophys Res Commun 242:613-20. 1998
    ..4-1BB-mediated NF-kappa B activation was inhibited by a dominant negative-TRAF2 or -NF-kappa B-inducing kinase (NIK). These data suggest that 4-1BB functions may be mediated by NF-kappa B activation, which requires a TRAF2/NIK pathway...
  76. ncbi Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5
    N Mitsiades
    National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 61:2704-12. 2001
    ....
  77. ncbi Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death
    Georgios V Georgakis
    Department of Lymphoma Myeloma, M D Anderson Cancer Center MDACC, Houston, TX 77030, USA
    Br J Haematol 130:501-10. 2005
    ..Our data demonstrate that HGS-ETR1 and HGS-ETR2 monoclonal antibodies can induce cell death in a variety of cultured and primary lymphoma cells, and may have therapeutic value in lymphoma...
  78. pmc osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
    ....
  79. ncbi Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes
    Michael Karpusas
    Biogen, Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Mol Biol 315:1145-54. 2002
    ..Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D-E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA, TACI and BAFF-R...
  80. ncbi Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB
    Xuezhong Yang
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 63:1122-9. 2003
    ..Furthermore, we have found that we can improve TRAIL sensitivity in NB by reconstituting caspase 8 with IFN-gamma and TR2 with chemotherapeutic agents...
  81. ncbi Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Neurochem 96:706-18. 2006
    ..These findings support the hypothesis that TNF-alpha may play a role in the selective vulnerability of the nigrostriatal pathway associated with dopaminergic neurotoxicity and perhaps Parkinson's disease...
  82. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001
    ..In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA...
  83. ncbi TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease
    Linda C Burkly
    Department of Immunobiology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    Cytokine 40:1-16. 2007
    ..In addition to a perspective of the biology, we discuss potential therapeutic strategies targeting this pathway for the treatment of tissue injury, chronic inflammatory diseases and cancer...
  84. pmc CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
    Ann E Herman
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    J Exp Med 199:1479-89. 2004
    ..Thus, CD4+CD25+69- Tregs operate directly in the autoimmune lesion and are dependent on ICOS to keep it in a nondestructive state...
  85. ncbi TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
    B R Wong
    Laboratory of Immunology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 4:1041-9. 1999
    ..These results define a mechanism by which TRANCE activates Src family kinases and PKB and provide evidence of cross-talk between TRAF proteins and Src family kinases...
  86. pmc Role of SODD in regulation of tumor necrosis factor responses
    Hidetoshi Takada
    Advanced Medical Discovery Institute, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    Mol Cell Biol 23:4026-33. 2003
    ..Interestingly, the apoptotic arm of TNF signaling is not hyperresponsive in the SODD-deficient cells. Together, these results suggest that SODD is critical for the regulation of TNF signaling...
  87. ncbi Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine and the Houston VA, Houston, Tex 77030, USA
    Circulation 109:1594-602. 2004
    ..Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure...
  88. pmc Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor
    W R Godfrey
    Department of Pathology, Stanford University School of Medicine, California 94305
    J Exp Med 180:757-62. 1994
    ..We describe gp34 as a new member of the TNF family, and find that the recombinant ligand expressed in COS cells costimulates phorbol myristate acetate, phytohemagglutinin, and anti-CD3-induced CD4+ T cell proliferation...
  89. ncbi Control of synaptic strength by glial TNFalpha
    Eric C Beattie
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Science 295:2282-5. 2002
    ..Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury...
  90. ncbi Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis
    Helmut Franck
    Center of Rheumatology, Oberammergau and the Department of Gastroenterology, Endocrinology and Metabolism, Philipps University, Marburg, Germany
    J Rheumatol 31:2236-41. 2004
    ..Osteoporosis occurs frequently in patients with AS and OPG represents a soluble decoy receptor that neutralizes receptor activator of nuclear factor-kB ligand (RANKL), an essential cytokine for osteoclast function...
  91. pmc BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Australia
    J Clin Invest 112:286-97. 2003
    ..These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases...
  92. ncbi Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat
    M Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Neurosci Lett 347:179-82. 2003
    ..TNFR upregulation in injured and adjacent uninjured DRG neurons may be essential for mediating enhanced TNF effects and thus contribute to the development of pain-related behavior...
  93. ncbi Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
    Kazuo Sugamura
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Nat Rev Immunol 4:420-31. 2004
  94. ncbi The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
    Arthritis Rheum 50:2750-6. 2004
    ..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...
  95. ncbi Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses
    I Gramaglia
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 161:6510-7. 1998
    ..These data suggest that Ox-40/Ox-40L interactions act after initial activation events to prolong clonal expansion and enhance effector cytokine secretion, and may be involved in promoting long-lived primary CD4 responses...
  96. ncbi Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
    R M Pitti
    Department of Molecular Oncology, Molecular Biology, and Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 396:699-703. 1998
    ..Thus, certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL...
  97. ncbi NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    O N Ozes
    Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, Indianapolis 46202, USA
    Nature 401:82-5. 1999
    ..Mutation of this amino acid blocks phosphorylation by Akt or TNF and activation of NF-kappaB. These findings indicate that Akt is part of a signalling pathway that is necessary for inducing key immune and inflammatory responses...
  98. ncbi The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract
    M S Sheikh
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncogene 18:4153-9. 1999
    ..It is, therefore, possible that TRID overexpressing GIT tumors may gain a selective growth advantage by escaping from TRAIL-induced apoptosis...
  99. pmc Etanercept, infliximab, and leflunomide in established rheumatoid arthritis: clinical experience using a structured follow up programme in southern Sweden
    P Geborek
    Department of Rheumatology, Lund University Hospital, S 221 85 Lund, Sweden
    Ann Rheum Dis 61:793-8. 2002
    ....
  100. ncbi Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    FASEB J 20:670-82. 2006
    ..Taken together, our results are indicative of a region-specific and dual role for TNF-alpha in the brain: a promoter of neurodegeneration in striatum and a protector against neurodegeneration in hippocampus...
  101. ncbi Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop
    Clarissa von Haefen
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, University of Berlin, Germany
    Oncogene 22:2236-47. 2003
    ..In addition, this is the first report to demonstrate death receptor-independent caspase-8 autoprocessing in vivo...

Research Grants81

  1. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2003
    ..abstract_text> ..
  2. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2007
    ..abstract_text> ..
  3. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor M Amiji; Fiscal Year: 2010
    ..In addition, NiMOS would be useful for other oral gene therapy strategies for treatment of diseases or oral DNA vaccination. ..
  4. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor Amiji; Fiscal Year: 2009
    ..In addition, NiMOS would be useful for other oral gene therapy strategies for treatment of diseases or oral DNA vaccination. ..
  5. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2006
    ..abstract_text> ..
  6. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2005
    ..abstract_text> ..
  7. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2003
    ..abstract_text> ..
  8. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2004
    ..abstract_text> ..
  9. CYTOKINE REGULATION IN SEPSIS AND INFLAMMATION
    Lyle Moldawer; Fiscal Year: 1993
    ..Such studies will strengthen our fundamental understanding of the metabolic response to injury and infection, and will provide a sound theoretical basis for future attempts to modulate the host response to injury and infection...
  10. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2004
    ..abstract_text> ..
  11. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2003
    ..abstract_text> ..
  12. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2005
    ..abstract_text> ..
  13. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2006
    ..abstract_text> ..
  14. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ....
  15. Cytoprotective cytokine signaling and reperfusion injury
    Douglas Mann; Fiscal Year: 2009
    ....
  16. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2005
    ..3). To determine whether overexpression of Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) in mouse lung exacerbates silica- induced lung injury. ..
  17. Decoy receptor 3 and liver cirrhosis
    Sunghee Kim; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  18. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2004
    ..3). To determine whether overexpression of Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) in mouse lung exacerbates silica- induced lung injury. ..
  19. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2002
    ..3). To determine whether overexpression of Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) in mouse lung exacerbates silica- induced lung injury. ..
  20. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2006
    ..3). To determine whether overexpression of Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) in mouse lung exacerbates silica- induced lung injury. ..
  21. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2002
    ..3). To determine whether overexpression of Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) in mouse lung exacerbates silica- induced lung injury. ..
  22. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2003
    ..3). To determine whether overexpression of Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) in mouse lung exacerbates silica- induced lung injury. ..
  23. Biomarkers of Vascular Disease Progression in Type 1 Diabetes Mellitus
    Maria Lopes Virella; Fiscal Year: 2009
    ..Competitive Revision to measure VCAM-1, ICAM-1, E-selectin, PAI-1, fibrinogen, CRP, IL-6, and soluble tumor necrosis factor receptors in these samples...
  24. Regulation of NF-kB in Lung Epithelium by ROS/RNS
    Yvonne Janssen Heininger; Fiscal Year: 2003
    ..abstract_text> ..
  25. Redox Mechanisms of Ischemia Reperfusion Injury in the Liver
    JOHN ENGELHARDT; Fiscal Year: 2009
    ..e., stroke and cardiac infarct), hence, the proposed research may also enhance of our understanding of ischemic injuries in other organs. ..
  26. Redox Mechanisms of Ischemia Reperfusion Injury in the Liver
    John F Engelhardt; Fiscal Year: 2010
    ..e., stroke and cardiac infarct), hence, the proposed research may also enhance of our understanding of ischemic injuries in other organs. ..
  27. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2007
    ..abstract_text> ..
  28. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2006
    ..abstract_text> ..
  29. Soluble Decoy Receptor 3 in Bacterial Infection and Sepsis
    Sunghee Kim; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  30. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ....
  31. SLEEP REGULATION AND TUMOR NECROSIS FACTOR
    James Krueger; Fiscal Year: 1993
    ....
  32. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  33. MOLECULAR MECHANISMS OF TUMOR NECROSIS FACTOR
    David Spriggs; Fiscal Year: 1990
    ....
  34. Respiratory Muscle Weakness in Chronic Inflammation
    Michael Reid; Fiscal Year: 2009
    ..The goal of this project is to identify new therapies that preserve respiratory muscle function in order to lessen illness and prolong life. ..
  35. Respiratory Muscle Weakness in Chronic Inflammation
    Michael B Reid; Fiscal Year: 2010
    ..The goal of this project is to identify new therapies that preserve respiratory muscle function in order to lessen illness and prolong life. ..
  36. NGF Receptor Regulates Prostate Growth
    Daniel Djakiew; Fiscal Year: 2009
    ..By lead compound optimization, we anticipate the development of novel chemotherapeutics with a novel mechanism of action for the treatment of prostate cancer. ..
  37. FINE MAPPING OF TNF RECEPTOR BINDING DOMAIN(S)
    MANN JY CHEN; Fiscal Year: 1993
    ..Important information regarding to the binding of TNF to each receptor and their functional implications can be obtained from this study whether the hypothesis tested true or not...
  38. ADPKD: Understanding mechanisms, Discovering treatments.
    Xiaogang Li; Fiscal Year: 2010
    ..The information from our studies will be likely to open new avenues in the research of ADPKD and establish the foundation for developing effective therapies of the disease. ..
  39. Regulation of lymphocyte survival by NF-kB proteins
    Amer Beg; Fiscal Year: 2002
    ..These studies may also provide insights into development of strategies for enhancing lymphopoiesis under therapeutic settings. ..
  40. Regulation of lymphocyte survival by NF-kB proteins
    Amer Beg; Fiscal Year: 2004
    ..These studies may also provide insights into development of strategies for enhancing lymphopoiesis under therapeutic settings. ..
  41. Regulation of lymphocyte survival by NF-kB proteins
    Amer Beg; Fiscal Year: 2003
    ..These studies may also provide insights into development of strategies for enhancing lymphopoiesis under therapeutic settings. ..
  42. Role of NF-kB activation in acute allograft rejection
    Maria Luisa Alegre; Fiscal Year: 2010
    ..In this application we propose to investigate the mechanisms by which TCR-CARMA1-NF-?B regulates formation of nTregs, iTregs and Th17 cells and how these effects impact allograft fate. ..
  43. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2001
    ....
  44. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2009
    ....
  45. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2006
    ....
  46. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2004
    ....
  47. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2002
    ....
  48. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2005
    ....
  49. REGULATION OF CD8 T CELL IMMUNITY BY TNF RECEPTORS
    Marulasiddappa Suresh; Fiscal Year: 2003
    ....
  50. Sulfur-pi: a highly stabilizing binding motif in TNF receptors
    Jonathan N Sachs; Fiscal Year: 2010
    ..This work will reveal new and critical chemical details about these proteins that can then be used for designing new treatments. ..
  51. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2005
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  52. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2004
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  53. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2003
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  54. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Low density lipoprotein receptor-related protein has emerged as an important regulator of inflammation and atherosclerosis. This proposal seeks to elucidate the responsible mechanisms. ..
  55. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2002
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  56. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Low density lipoprotein receptor-related protein has emerged as an important regulator of inflammation and atherosclerosis. This proposal seeks to elucidate the responsible mechanisms. ..
  57. ADHESION-DEPENDENT NEUTROPHIL RESPIRATORY BURST
    Carl Nathan; Fiscal Year: 1992
    ....
  58. CD40 SIGNAL TRANSDUCTION
    Claudius Vincenz; Fiscal Year: 1999
    ..Specific Aim 3: Determine if CD40bp and TRAF2 modulate other CD40 signaling events including activation of cytoplasmic src-like kinases and PI3 kinase. ..
  59. Targeting GITR for Tumor Immunotherapy
    Adam Cohen; Fiscal Year: 2007
    ..Gaining greater mechanistic understanding of the effects of anti-GITR antibody on tumor immunity will allow for more rational translation of this promising immunotherapeutic approach to the clinic. [unreadable] [unreadable] [unreadable]..
  60. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Development of highly specific imaging agents for noninvasive detection of inflammation induced by heart attacks. ..
  61. Herpes simplex virus receptors and signal transduction
    PATRICIA SPEAR; Fiscal Year: 2002
    ..The studies described in this proposal are distinct from those supported by the parent grant but address questions that arise from findings made in the parent project. ..
  62. Herpes simplex virus receptors and signal transduction
    PATRICIA SPEAR; Fiscal Year: 2003
    ..The studies described in this proposal are distinct from those supported by the parent grant but address questions that arise from findings made in the parent project. ..
  63. THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2003
    ..abstract_text> ..
  64. THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2001
    ..abstract_text> ..
  65. THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2005
    ..abstract_text> ..
  66. THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2004
    ..abstract_text> ..
  67. Cell-Based Assays for Identifying Anti-RANK Signaling Agents
    Xu Feng; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  68. THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2002
    ..abstract_text> ..
  69. Pathogenesis of cutaneous lupus erythematosus
    Guo Min Deng; Fiscal Year: 2010
    ..Upon the completion of the proposed studies specific inhibitors of TNF receptor signaling will be proposed as novel therapeutics of autoimmune skin lesions. ..
  70. Brain Endothelial TNF-R1 Can Function to Inhibit Angiogenesis
    Candece L Gladson; Fiscal Year: 2010
    ..This approach would be a significant advance over the therapies currently being tested that retard the growth of the blood vessels, but do not eliminate them. ..
  71. HEPATITIS C VIRUS PERSISTENCE AND PATHOGENESIS
    Michael Lai; Fiscal Year: 1999
    ..These studies are expected to contribute to the understanding of viral pathogenesis and persistent infection. ..
  72. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2002
    ....
  73. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2003
    ....
  74. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2001
    ....
  75. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2004
    ....
  76. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2003
    ....
  77. Regulation of Type 2 NF-kappaB Activation and Inflammation
    Genhong Cheng; Fiscal Year: 2009
    ..Elucidating the molecular mechanisms responsible for inhibiting NF-kB activity will undoubtedly help in designing novel strategies to treat human diseases associated overactivation of NF-kB. ..
  78. TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITY
    GOKHAN HOTAMISLIGIL; Fiscal Year: 2005
    ....
  79. Regulation of Type 2 NF-kappaB Activation and Inflammation
    Genhong Cheng; Fiscal Year: 2010
    ..Elucidating the molecular mechanisms responsible for inhibiting NF-kB activity will undoubtedly help in designing novel strategies to treat human diseases associated overactivation of NF-kB. ..