interleukin receptors

Summary

Summary: Cell surface proteins that bind interleukins and trigger intracellular changes influencing the behavior of cells.

Top Publications

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  2. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
  3. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
  4. pmc Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    S J Szabo
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 185:817-24. 1997
  5. ncbi Interleukin-17 family and IL-17 receptors
    T A Moseley
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Cytokine Growth Factor Rev 14:155-74. 2003
  6. ncbi Interleukin-18 regulates both Th1 and Th2 responses
    K Nakanishi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Annu Rev Immunol 19:423-74. 2001
  7. pmc Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    P Ye
    Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
    J Exp Med 194:519-27. 2001
  8. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
  9. pmc IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
    Virginie Carriere
    Laboratoire de Biologie Vasculaire, Equipe Labellisée La Ligue 2006, Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse, France
    Proc Natl Acad Sci U S A 104:282-7. 2007
  10. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007

Research Grants

Detail Information

Publications259 found, 100 shown here

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...
  2. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    ..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
  3. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  4. pmc Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    S J Szabo
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 185:817-24. 1997
    ..Thus, IFN-gamma may prevent early Th cells from premature commitment to the Th2 pathway. Controlling the expression of the IL-12R beta 2 subunit could be an important therapeutic target for the redirection of ongoing Th cell responses...
  5. ncbi Interleukin-17 family and IL-17 receptors
    T A Moseley
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Cytokine Growth Factor Rev 14:155-74. 2003
    ..This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues...
  6. ncbi Interleukin-18 regulates both Th1 and Th2 responses
    K Nakanishi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Annu Rev Immunol 19:423-74. 2001
    ..Therefore, the functions of IL-18 in vivo are very heterogeneous and complicated. In principle, IL-18 enhances the IL-12-driven Th1 immune responses, but it can also stimulate Th2 immune responses in the absence of IL-12...
  7. pmc Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    P Ye
    Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
    J Exp Med 194:519-27. 2001
    ..pneumoniae infection. These data support impaired IL-17R signaling as a potential mechanism by which deficiency of CD4 lymphocytes predisposes to bacterial pneumonia...
  8. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
    ..In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs...
  9. pmc IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
    Virginie Carriere
    Laboratoire de Biologie Vasculaire, Equipe Labellisée La Ligue 2006, Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse, France
    Proc Natl Acad Sci U S A 104:282-7. 2007
    ..Together, these data suggest that, similarly to IL1alpha and HMGB1, IL-33 is a dual function protein that may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties...
  10. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007
    ....
  11. pmc IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways
    A M O'Farrell
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA 94304 1104, USA
    EMBO J 17:1006-18. 1998
    ..Thus signals mediating both anti-proliferative and macrophage de-activation responses to IL-10 require the two membrane-distal tyrosines of IL-10R, but Stat3 appears to function only in the anti-proliferative response...
  12. ncbi Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation
    L Robb
    Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Victoria, Australia
    Nat Med 4:303-8. 1998
    ..These observations reveal a previously unrecognized critical role for IL-11 signaling in female reproduction...
  13. ncbi A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
    Christi Parham
    Department of Immunology, DNAX Research, Palo Alto, CA 94304, USA
    J Immunol 168:5699-708. 2002
    ..The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12Rbeta2, respectively. The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12Rbeta2...
  14. ncbi Interleukin-17 family members and inflammation
    Jay K Kolls
    Division of Pulmonology, Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, PA, USA
    Immunity 21:467-76. 2004
    ..Increasing evidence shows that IL-17 family members play an active role in inflammatory diseases, autoimmune diseases, and cancer. This places IL-17 family members and their receptors as potential targets for future pharmacotherapy...
  15. pmc Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes
    M Watanabe
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Clin Invest 95:2945-53. 1995
    ..These findings suggest that human intestinal epithelial cells and epithelial goblet cells produce IL-7, and locally produced IL-7 may serve as a potent regulatory factor for intestinal mucosal lymphocytes...
  16. ncbi Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
    A C Mullen
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Science 292:1907-10. 2001
    ..These results suggest that a cytokine does not simply induce TH fate choice but instead may act as an essential secondary stimulus that mediates selective survival of a lineage...
  17. ncbi IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1
    J Lee
    Department of Molecular Biology, Genentech Inc, San Francisco, California 94080, USA
    J Biol Chem 276:1660-4. 2001
    ..IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8...
  18. pmc Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells
    J T Chang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 189:969-78. 1999
    ..These results suggest that the development of immunotherapies that target the IL-12Rbeta2 subunit may be useful for the treatment of autoimmune diseases...
  19. ncbi IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex
    Alissa A Chackerian
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, CA 94304, USA
    J Immunol 179:2551-5. 2007
    ..The implications of this shared usage of IL-1RAcP by IL-1(alpha and beta) and IL-33 are discussed...
  20. ncbi Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy
    Irma Airoldi
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Blood 106:3846-53. 2005
    ..The development of autoimmunity, lymphoproliferation, and B-cell tumors in Il12rb2 knockout (KO) mice suggests that IL-12 functions physiologically to restrain aberrant B-cell activation...
  21. ncbi Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients
    Keiko Yamazaki
    Laboratory for Gastrointestinal Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
    J Hum Genet 52:575-83. 2007
    ..Further genetic studies are required to confirm our findings with ethnically divergent populations...
  22. ncbi Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction
    Alan C Mullen
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Nat Immunol 3:652-8. 2002
    ..These findings suggest that heritable states of gene expression might be maintained by continued expression of the inducing factor or by a mechanism that confers a stable imprint of the induced state...
  23. ncbi IL-31: a new link between T cells and pruritus in atopic skin inflammation
    Eniko Sonkoly
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    J Allergy Clin Immunol 117:411-7. 2006
    ..IL-31 is a novel T-cell-derived cytokine that induces severe pruritus and dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL-31 receptor A and oncostatin M receptor...
  24. ncbi Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
    Stacey R Dillon
    Department of Immunology, ZymoGenetics, 1201 Eastlake Avenue East, Seattle, Washington 98102, USA
    Nat Immunol 5:752-60. 2004
    ..These data indicate that IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases...
  25. ncbi Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells
    Xiang Yue Zhang
    Department of Microbiology and Etiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
    Immunogenetics 57:934-43. 2006
    ....
  26. ncbi IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
    M G Chiaramonte
    Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
    J Immunol 162:920-30. 1999
    ..Together, these data demonstrate that IL-13 serves as an important mediator of Th2-mediated inflammation and plays a role in eliciting IgE responses triggered by schistosome eggs...
  27. ncbi IL-12 and IL-23: master regulators of innate and adaptive immunity
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    Immunol Rev 202:96-105. 2004
    ..These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression...
  28. pmc Interleukin 7 receptor-deficient mice lack gammadelta T cells
    K Maki
    Department of Disease Related Gene Regulation Research Sandoz Faculty of Medicine, The Univerisity of Tokyo, Japan
    Proc Natl Acad Sci U S A 93:7172-7. 1996
    ..On the contrary, it is suggested that NK-cell development requires cytokine(s) other than IL-7...
  29. ncbi The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12
    H Himmelrich
    World Health Organization Immunology Research and Training Center, Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    J Immunol 161:6156-63. 1998
    ..major is primarily based on an up-regulation of IL-4 production, which secondarily induces extinction of IL-12 signaling...
  30. ncbi Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site
    K Josephson
    Center for Macromolecular Crystallography, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 15:35-46. 2001
    ..The data suggests that formation of the active IL-10 signaling complex occurs by a novel molecular recognition paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on IL-10...
  31. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..Therefore, the decision of antigen-stimulated cells to differentiate into either T(H)17 or T(reg) cells depends on the cytokine-regulated balance of RORgammat and Foxp3...
  32. pmc Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    J J Peschon
    Immunex Research and Development Corporation, Seattle, Washington 98101
    J Exp Med 180:1955-60. 1994
    ..Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7...
  33. ncbi Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
    T L Born
    Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 273:29445-50. 1998
    ..We propose that although IL-1R-rp1 binds the cytokine, IL-1R-rp1 and AcPL proteins are both required for IL-18 signaling, analogous to the requirement for both IL-1R and IL-1RAcP in IL-1-mediated responses...
  34. pmc Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response
    Monica G Chiaramonte
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:687-701. 2003
    ..Together, these studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response...
  35. ncbi GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet
    Takashi Usui
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 18:415-28. 2003
    ..These findings reassert that Stat4 signaling is a central element of Th1/Th2 development...
  36. ncbi IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis
    Janine Bilsborough
    Department of Autoimmunity and Inflammation, ZymoGenetics, Inc, Seattle, WA 98102, USA
    J Allergy Clin Immunol 117:418-25. 2006
    ..IL-31 is a newly discovered T-cell cytokine that, when overexpressed in mice, results in pruritus and skin dermatitis resembling human atopic dermatitis (AD)...
  37. pmc The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 10:314-24. 2009
    ..These defects were associated with less proliferation; consequently, fewer effector T(H)-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues...
  38. pmc Interleukin-12 in infectious diseases
    L Romani
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Clin Microbiol Rev 10:611-36. 1997
    ..Continued investigation into the possible application of IL-12 therapy to human infections is warranted by the role of the cytokine in inflammation, immunopathology, and autoimmunity...
  39. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  40. ncbi Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells
    Marieke A Hoeve
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 36:661-70. 2006
    ....
  41. ncbi Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability
    Z Mallat
    Institut National de la Sante et de la Recherche Medicale, INSERM U541, Institut Fédératif de Recherche Circulation Paris VII, Hopital Lariboisiere, Paris, France
    Circulation 104:1598-603. 2001
    ..Interleukin (IL)-18 is a potent proinflammatory cytokine with potential atherogenic properties. Its expression and role in atherosclerosis, however, are unknown...
  42. ncbi Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells
    David Moulin
    Division of Rheumatology, University Hospital, University of Geneva School of Medicine, 26 Avenue Beau Sejour, 1211, Geneva 14, Switzerland
    Cytokine 40:216-25. 2007
    ..These findings open new perspectives for the treatment of inflammatory diseases by targeting IL-33...
  43. pmc Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology
    Lucia E Rosas
    Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
    Am J Pathol 168:158-69. 2006
    ..Additionally, the data demonstrate that although the IL-27/TCCR interaction limits the severity of liver inflammation during VL by controlling CD4(+) T-cell activity, it is not required for the resolution of hepatic immunopathology...
  44. pmc Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1
    Brandi C Jones
    Center for Biophysical Sciences and Engineering, Department of Microbiology, University of Alabama, 1025 18th Street South, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 99:9404-9. 2002
    ..Our results suggest cmvIL-10 and ebvIL-10 have evolved different molecular mechanisms to engage the IL-10 receptors that ultimately enhance the respective ability of their virus to escape immune detection...
  45. pmc In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    Franck J Barrat
    DNAX Research Institute, Department of Immunology, Palo Alto, CA 94304, USA
    J Exp Med 195:603-16. 2002
    ..Generating homogeneous populations of IL-10-producing T cells in vitro will thus facilitate the use of regulatory T cells in immunotherapy...
  46. ncbi A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    Richard H Duerr
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Science 314:1461-3. 2006
    ..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease...
  47. ncbi cDNA cloning and characterization of the human interleukin 13 receptor alpha chain
    M J Aman
    Laboratory of Molecular Immunology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    J Biol Chem 271:29265-70. 1996
    ..Nevertheless, the overall size and length of the cytoplasmic domain of IL-13Ralpha and gammac are similar, and like gammac, IL-13Ralpha is located on chromosome X...
  48. pmc Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family
    H Li
    Department of Molecular Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 97:773-8. 2000
    ..These data show that there is a family of IL-17-related cytokines differing in patterns of expression and proinflammatory responses that may be transduced through a cognate set of cell surface receptors...
  49. pmc IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease
    Mark Tremelling
    IBD Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge, England, UK
    Gastroenterology 132:1657-64. 2007
    ..We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15...
  50. ncbi Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol
    John Rømer
    Discovery, Novo Nordisk, Bagsvaerd, Denmark
    J Invest Dermatol 121:1306-11. 2003
    ..These findings show that IL-19 and IL-20 are synthesized by a distinct population of keratinocytes. It remains to be clarified whether IL-19 and IL-20 are implicated in the pathogenesis of psoriasis...
  51. ncbi Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains
    J G Zhang
    Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Victoria 3050, Australia
    J Biol Chem 272:9474-80. 1997
    ..Finally, unlike the cloned receptor, the IL-13BP acts as a potent inhibitor of IL-13 binding to its cell surface receptor, raising the possibility that it may be used to modulate the effects of IL-13 in vivo...
  52. pmc A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production
    M Neighbors
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Incorporated, Palo Alto, CA 94304, USA
    J Exp Med 194:343-54. 2001
    ..Therefore, IL-18 operates via its effects on both the innate immune response, including macrophages, as well as on Th1 cells, to protect against Listeria...
  53. ncbi Contribution of activated interleukin receptors in trigeminal ganglion neurons to hyperalgesia via satellite glial interleukin-1beta paracrine mechanism
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
    Brain Behav Immun 22:1016-23. 2008
    ..Such an IL-1beta release could be important in determining trigeminal inflammatory hyperalgesia...
  54. ncbi Defective lymphoid development in mice lacking Jak3
    T Nosaka
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 270:800-2. 1995
    ..Thus, Jak3 plays a critical role in gamma c signaling and lymphoid development...
  55. pmc Investigation of association of the IL12B and IL23R genes with psoriatic arthritis
    Charlotte Filer
    University of Manchester, Manchester, UK
    Arthritis Rheum 58:3705-9. 2008
    ..The aim of this study was to determine whether these variants are also associated with susceptibility to psoriatic arthritis (PsA)...
  56. ncbi Differential IL-10R1 expression plays a critical role in IL-10-mediated immune regulation
    Y Ding
    Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 167:6884-92. 2001
    ..Modulation of cell surface IL-10R1 density might be an important mechanism for determining whether IL-10 leads to immunostimulation or immunosuppression in vivo...
  57. ncbi Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex
    B Miloux
    Sanofi Recherche, Labege Innopole, France
    FEBS Lett 401:163-6. 1997
    ..Electrophoretic mobility shift assay showed that IL-13 and IL-4 were able to activate Stat6 in cells expressing both IL-4R alpha and IL-13R alpha1, while no activation was observed in cells expressing either one or the other alone...
  58. ncbi Interferon-gamma-inducing activity of interleukin-18 in the joint with rheumatoid arthritis
    M Yamamura
    Department of Medicine III, Okayama University Medical School, Japan
    Arthritis Rheum 44:275-85. 2001
    ..Detection of significant IL-18 bioactivity in the joints, despite the presence of IL-18 binding inhibitors, supports an integral role of this cytokine in perpetuating the IFNgamma-dominant T cell cytokine response in RA...
  59. ncbi Is there an interaction between interleukin-10 and interleukin-22?
    K Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, D 10117 Berlin, Germany
    Genes Immun 6:8-18. 2005
    ..However, IL-10R2 interacted with defined IL-10- and IL-22-derived peptides supporting the hypothesis that cytokine binding to its corresponding R1 chain creates a binding site on this cytokine for IL-10R2...
  60. ncbi Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization
    Marehalli L Nagalakshmi
    Department of Experimental Pathology and Pharmacology, DNAX Research Inc, 901 California Avenue, Palo Alto, CA 94304 1104, USA
    Int Immunopharmacol 4:577-92. 2004
    ..These data point to a function of the novel IL-10 family members in communication and interaction between cells of the hematopoietic and non-hematopoietic lineages, a role quite distinct from the immunomodulating effects of IL-10 itself...
  61. ncbi Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer
    Dominik Haudenschild
    Center for Tissue Regeneration and Repair and Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    J Biol Chem 277:4309-16. 2002
    ..Using antibodies directed at the cytoplasmic and extracellular domains of this protein, we investigated its localization and found that it was expressed in a variety of normal human tissues including prostate and in prostate cancer...
  62. ncbi The role of IL-18 in innate immunity
    S Akira
    Department of Host Defense, CREST of Japan Science and Technology Corporation, Research Institute for Microbial Diseases, Osaka University, Suita, 565 0871, Japan
    Curr Opin Immunol 12:59-63. 2000
    ..The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response...
  63. ncbi The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors
    D R Moritz
    Department of Pathology, University Hospital Zurich, Switzerland
    J Immunol 161:4866-74. 1998
    ....
  64. pmc Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment
    Marcin Kortylewski
    Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA
    Cancer Cell 15:114-23. 2009
    ..These results demonstrate that Stat3 promotes IL-23-mediated procarcinogenic immune responses while inhibiting IL-12-dependent antitumor immunity...
  65. ncbi Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
    W Ouyang
    Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Immunity 9:745-55. 1998
    ..Thus, GATA-3 expression and IL-12 signaling are mutually antagonistic, which facilitates rapid dominance of one pathway during early Th development, producing a stable divergence in cytokine profiles...
  66. ncbi Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma
    A Zdanov
    Macromolecular Structure Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Structure 3:591-601. 1995
    ..An atomic model is necessary to interpret biological activity of IL-10 and to design mutants with agonistic or antagonistic properties...
  67. ncbi IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites
    C Wu
    Department of Inflammation Autoimmune Diseases, Hoffmann LaRoche, Nutley, NJ 07110, USA
    J Immunol 165:6221-8. 2000
    ..These results demonstrate that although mouse IL-12R beta 1 is the subunit primarily responsible for binding IL-12, IL-12R beta 2 plays an essential role in mediating the biological functions of IL-12 in mice...
  68. pmc A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    Michele Cargill
    Celera, Alameda, CA 94502, USA
    Am J Hum Genet 80:273-90. 2007
    ..These data, and the previous observation that administration of an antibody specific for the IL-12p40 subunit to patients with psoriasis is highly efficacious, suggest that these genes play a fundamental role in psoriasis pathogenesis...
  69. pmc T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses
    M J Townsend
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Exp Med 191:1069-76. 2000
    ..These data clearly demonstrate that T1/ST2 expression plays a role in the development of Th2-like cytokine responses and indicate that effector functions are inhibited in its absence...
  70. ncbi Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis
    F Altare
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Universite Rene Descartes, INSERM U550, Faculte de Medecine Necker, Paris, France
    J Infect Dis 184:231-6. 2001
    ..A diagnosis of IL-12Rbeta1 deficiency should therefore be considered in selected patients with severe tuberculosis, despite their resistance to BCG and a lack of atypical mycobacteriosis...
  71. ncbi Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
    A E Corcoran
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nature 391:904-7. 1998
    ..This mechanism augments the recombinational diversity of the primary antibody repertoire...
  72. ncbi Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless
    S Brown
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Curr Biol 11:1700-5. 2001
    ..Like many interleukin receptors, DOME has a cytokine binding homology module (CBM) and three extracellular fibronectin-type-III domains (..
  73. pmc T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function
    M Lohning
    Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 95:6930-5. 1998
    ..Administration of either a mAb against T1/ST2 or recombinant T1/ST2 fusion protein attenuates eosinophilic inflammation of the airways and suppresses IL-4 and IL-5 production in vivo following adoptive transfer of Th2 cells...
  74. ncbi Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu
    K Nakanishi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Cytokine Growth Factor Rev 12:53-72. 2001
    ..Moreover, IL-18 also induces IL-13 and/or IL-4 production by NK cells, mast cells and basophils. Therefore, IL-18 should be seen as a unique cytokine that enhances innate immunity and both Th1- and Th2-driven immune responses...
  75. ncbi Crystal structure of interleukin 10 reveals an interferon gamma-like fold
    M R Walter
    Department of Pharmacology, University of Alabama at Birmingham 35294, USA
    Biochemistry 34:12118-25. 1995
    ..Interleukin 10 and IFN-gamma contain several conserved residues in their internal cores which suggest a possible "fingerprint" for detection of other members of this fold...
  76. pmc Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction
    D J Hilton
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria
    EMBO J 13:4765-75. 1994
    ..The expression of both NR1 and gp130 was also necessary for Ba/F3 cells to proliferate and M1 cells to undergo macrophage differentiation in response to IL-11...
  77. ncbi IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells
    T Sareneva
    Department of Virology, National Public Health Institute, Helsinki, Finland
    J Immunol 165:1933-8. 2000
    ..In conclusion, the results suggest that IFN-alpha and IL-12 enhance innate as well as Th1 immune response by inducing IL-18R expression...
  78. pmc Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses
    A J Coyle
    Department of Biology, Inflammation Division, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Exp Med 190:895-902. 1999
    ..Taken together, our data demonstrate an important role of T1/ST2 in Th2-mediated inflammatory responses and suggest that T1/ST2 may prove to be a novel target for the selective suppression of Th2 immune responses...
  79. ncbi Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor
    M Noguchi
    Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Science 262:1877-80. 1993
    ..These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma...
  80. ncbi Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain
    D Caput
    Sanofi Recherche, BP 137, 31676 Labège Cedex, France
    J Biol Chem 271:16921-6. 1996
    ..Reverse transcription-polymerase chain reaction analysis detected the receptor transcript only in cell lines known to bind IL-13...
  81. pmc Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively
    M Takagi
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304
    J Exp Med 181:889-99. 1995
    ..These results strongly suggest that the lineage specificity of IL-5 is mainly due to the restricted expression of IL-5R alpha...
  82. ncbi A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma
    Michael O Daines
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 277:10387-93. 2002
    ..These results provide the first evidence that the IL-13Ralpha2 is predominantly an intracellular molecule and demonstrate a novel mechanism by which IFN-gamma can regulate IL-13 responses...
  83. ncbi IL-4 and IL-13 receptors: are they one and the same?
    R E Callard
    Immunobiology Unit, Institute of Child Health, London, UK
    Immunol Today 17:108-10. 1996
    ..Indeed, as discussed here by Robin Callard and colleagues, the IL-13 receptor appears to be a functional receptor for IL-4...
  84. ncbi IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304 1104, USA
    J Immunol 165:4950-6. 2000
    ....
  85. ncbi Missense mutation of the interleukin-12 receptor beta1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infection
    T Sakai
    Department of Immunopathophysiology and Internal Medicine II, Kumamoto University School of Medicine, Japan
    Blood 97:2688-94. 2001
    ....
  86. ncbi The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway
    K Kawakami
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 97:2673-9. 2001
    ..Taken together, these observations indicate that internalization of IL-13Ralpha2 is signal independent and that this property of IL-13Ralpha2 can be exploited for receptor-directed cancer therapy...
  87. pmc A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    Ying Liu
    Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 4:e1000041. 2008
    ..This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis)...
  88. ncbi Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses
    Grant Gallagher
    Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Room C 636, MSB, 185 South Orange Avenue, Newark, NJ 07103, USA
    Int Immunopharmacol 4:615-26. 2004
    ..Furthermore, in whole PBMC cultures, IL-19 up-regulated IL-4 and down-regulated IFNgamma in a dose-dependent manner. These results are presented here in review format, in the context of an overall discussion of IL-19 and its receptor...
  89. ncbi Cell-cell contact of human T cells with fibroblasts changes lymphocytic mRNA expression: increased mRNA expression of interleukin-17 and interleukin-17 receptor
    K Thiele
    Institute of Medical Immunology, Martin Luther University Halle Wittenberg, Strasse der OdF 6, D 06097 Halle, Germany
    Eur Cytokine Netw 11:53-8. 2000
    ..Changes in the mRNA levels of Jurkat T cells induced by cell-cell contact with adherent cells were also found for M-type pyruvate kinase, for tropomyosin TM30 and for the p54nrb gene product...
  90. pmc Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice
    P Bilinski
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    Genes Dev 12:2234-43. 1998
    ..Therefore, IL-11Ralpha signaling at the implantation site appears to be required for decidua development...
  91. ncbi T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
    Maryam Afkarian
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Nat Immunol 3:549-57. 2002
    ..Thus, T-bet is induced by IFN-gamma and STAT1 signaling during T cell activation. In addition, T-bet mediates STAT1-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2...
  92. ncbi Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain
    R M Weber-Nordt
    Center for Immunology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:27954-61. 1996
    ....
  93. ncbi Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes
    S V Kotenko
    Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Biol Chem 276:2725-32. 2001
    ....
  94. ncbi Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit
    J Tavernier
    Flanders Interuniversity Institute for Biotechnology and Department of Respiratory Diseases, University of Ghent, Belgium
    Blood 95:1600-7. 2000
    ..Blood. 2000;95:1600-1607)..
  95. pmc Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor
    A Zdanov
    Macromolecular Structure Laboratory, NCI Frederick Cancer Research and Development Center, ABL Basic Research Program, Frederick, Maryland 21702, USA
    Protein Sci 5:1955-62. 1996
    ..The contact region between the cytokine and each receptor shows excellent complementarity of polar and hydrophobic interactions, suggesting that the model is generally correct and should be useful in guiding mutagenesis experiments...
  96. pmc Involvement of p59fynT in interleukin-5 receptor signaling
    M W Appleby
    Howard Hughes Medical Institute, Seattle, Washington 98195, USA
    J Exp Med 182:811-20. 1995
    ..Our results document the importance of p59fynT in IL-5 responses in B cells, and they support a general model for cytokine receptor signal transduction involving the simultaneous recruitment of at least three families of PTK...
  97. ncbi Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancer
    K Kawakami
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Cancer Res 61:6194-200. 2001
    ..c. in nude mice. These results demonstrate that by using a combination approach of gene transfer and systemic or locoregional cytotoxin therapy, the IL-13R represents a new potent target for head and neck cancer therapy...
  98. ncbi Interleukin-11 signals through the formation of a hexameric receptor complex
    V A Barton
    Cancer Research Campaign Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 275:36197-203. 2000
    ..We therefore propose that IL-11 forms a hexameric receptor complex composed of two molecules each of IL-11, IL-11R, and gp130...
  99. ncbi Clinical and genetic heterogeneity of inherited autosomal recessive susceptibility to disseminated Mycobacterium bovis bacille calmette-guérin infection
    Houda Elloumi-Zghal
    Laboratoire d Immunologie, Vaccinologie, et Génétique Moléculaire, Institut Pasteur de Tunis, Tunis, Tunisia
    J Infect Dis 185:1468-75. 2002
    ..The clinical severity of the mycobacterial infection was heterogeneous, even among affected members of the same family, which suggests the intervention of modifying genes...
  100. ncbi A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF
    J Tavernier
    Roche Research Gent, Belgium
    Cell 66:1175-84. 1991
    ....
  101. ncbi Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
    X Cao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Immunity 2:223-38. 1995
    ..These mice provide an important model for studying the pathophysiology provide an important model for studying the pathophysiology of and gene therapy for human XSCID...

Research Grants62

  1. Resolution of inflammation in healing myocardial infarcts
    Nikolaos G Frangogiannis; Fiscal Year: 2013
    ..In addition, the novel effects of IRAK-M on fibroblast function and its potential interactions with the TGF- [unreadable] pathway have important implications in the biology of tissue inflammation and repair. ..
  2. Molecular Mechanisms of Axon Degeneration
    Marc R Freeman; Fiscal Year: 2013
    ....
  3. Synthetic TIR Domain Mimetics as a Novel Strategy for Intervention in Sepsis
    Julius Rebek; Fiscal Year: 2010
    ..A collection of molecules will be synthesized, tested in cell lines and optimized for their activity in the treatment of sepsis in appropriate animal models. ..
  4. The BCL-2 Homologues of Gamma Herpesviruses
    J Marie Hardwick; Fiscal Year: 2006
    ..more open reading frames with recognizable homology to such cellular factors as chemokines, interleukins, interleukin receptors, cyclin, FLIP and BCL-2...
  5. REGULATION OF CELL ACTIVATION BY FATTY ACIDS
    ROBERT ZURIER; Fiscal Year: 2000
    ..in vitro and in vivo; studies will include determinations of interleukin-1 converting enzyme, the interleukin receptors, and the interleukin-1 receptor antagonist...
  6. DISCOVERY OF SMALL-MOLECULE MODULATORS OF IL-10 RECEPTOR
    Huw Nash; Fiscal Year: 2000
    ..be applied to other high-value drug targets which work by similar mechanisms, such as interferon and other interleukin receptors. PROPOSED COMMERCIAL APPLICATIONS: This project will develop a small-molecule antagonist of interleukin-10,..
  7. SELECTIVE EXPRESSION OF AGM1 DURING LYMPHOPOIESIS
    Robert Stout; Fiscal Year: 1990
    ..Early events in activation include the expression of interleukin receptors and apparently of the aGml glycolipid. It is not known how early expression of aGml occurs...
  8. Characterization of the IL-TIF Receptor Complex
    Sergei Kotenko; Fiscal Year: 2005
    ..The long-term goal of this project is to obtain new knowledge that will improve our understanding of mechanisms that regulate proper functioning of the immune system. ..
  9. Role of Interferon-lambda in Antiviral Response
    Sergei Kotenko; Fiscal Year: 2009
    ..abstract_text> ..
  10. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  11. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  12. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2010
    ..abstract_text> ..
  13. Ad-mda7 plus Herceptin against Breast Cancer
    Sunil Chada; Fiscal Year: 2002
    ..This strategy, if successful, could be further applied in human breast cancer trials. ..
  14. Mechanisms: IL-13 Induced Mucus Hypersecretion in Asthma
    Marsha Wills Karp; Fiscal Year: 2006
    ..A better understanding of the mechanisms underlying IL-13-induced mucus hypersecretion should guide the development of novel strategies for the treatment of asthma and other hypersecretory diseases of the lung. ..
  15. Nanoparticles for the Treatment of Lung Cancer
    Mingzhong Zheng; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. IDENTIFYING MAJOR SUSCEPTIBILITY GENES OF IBD
    JUDY CHO; Fiscal Year: 2003
    ..Once risk alleles are identified in multiplex families, characterization of the nature and broad significance of specific risk alleles for IBD in a variety of populations will be performed. ..
  17. Mapping Chromosome 3q Inflammatory Bowel Disease Genes
    JUDY CHO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. The Natural History of Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..abstract_text> ..
  19. IL-10 Receptor Signaling That Regulates Innate Immunity
    Robert Schreiber; Fiscal Year: 2008
    ....
  20. Virus-Induced Mechanics of Altered Airway Responsiveness
    Michael Grunstein; Fiscal Year: 2008
    ..It is anticipated that the findings from these proposed studies would yield important new insights into the mechanistic interplay between viral respiratory pathogens, atopy, and altered airway responsiveness. [unreadable] [unreadable]..
  21. Lineage decision in blood stem and progenitor cells
    Koichi Akashi; Fiscal Year: 2007
    ..Thus, we hope these studies will help understand mechanistic effects of these transcription factors on lineage decision in normal and malignant hematopoietic development. ..
  22. TLR4 as an LPS sendor and susceptibility locus
    Bruce Beutler; Fiscal Year: 2007
    ..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
  23. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2008
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  24. Mechanisms and Consequences of Toll Like Receptor Signal Transduction
    Stefanie Vogel; Fiscal Year: 2008
    ..3) Assess the mechanism of TLR tyrosine phosphorylation and its functional consequences. ..
  25. The Molecular and Cellular Basis of Cancer Immunoediting
    Robert Schreiber; Fiscal Year: 2008
    ..This work will provide the first molecular and mechanistic insights into the cancer immunoediting process and may also establish molecular guidelines to judge the extent to which a tumor has been edited. ..
  26. IL-10 Regulation of Lymphangiogenesis in Prostate Cancer
    Mark Stearns; Fiscal Year: 2008
    ..Overall, the studies should demonstrate whether the IL-10R axis and down stream effector genes (and specifically IL-10S1-VEGF D, and VEGF D) play a pivotal role in lymphangiogenesis and/or angiogenesis processes. ..
  27. Fibroproliferation in Bronchiolitis Obliterans Syndrome
    Vibha Lama; Fiscal Year: 2008
    ..Martinez MD, MS and Marc Peters-Golden MD, both of whom are well-funded researchers with a long track record of mentoring. ..
  28. ADENOVIRUS FLT3 LIGAND INDUCES NALT DCs FOR SALIVARY GLAND S-lgA Ab RESPONSES
    Kohtaro Fujihashi; Fiscal Year: 2010
    ..4) Determination of the precise mechanism for cross-talk between Ad-FL-induced salivary DCs, B-1 B cells and yS T cells for salivary S-lgA Ab responses. ..
  29. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  30. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  31. Conference Proposal: Transplantation Immunology
    Angus Thomson; Fiscal Year: 2004
    ..An important goal will be evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research. ..
  32. IMMUNE POTENTIAL OF ANIMAL LACKING CLASS IA MOLECULES
    JAMES M FORMAN; Fiscal Year: 2010
    ..In summary, this proposal will add important new information on how CDS T cells function in the innate immune response against intracellular pathogens. ..
  33. SIGNAL TRANSDUCTION IN SENSITIZED AIRWAY SMOOTH MUSCLE
    Michael Grunstein; Fiscal Year: 2002
    ....
  34. IL10 and IGF1 Receptor Axis in Prostate Cancer
    Mark Stearns; Fiscal Year: 2005
    ..Development of therapeutic agents, which target the IL-10R or IGF-R1 axis should be beneficial in the treatment of the disease. ..
  35. Conference:Cytokines, Disease & Therapeutic Intervention
    Mary Collins; Fiscal Year: 2004
    ..abstract_text> ..
  36. ROLES OF TOLL LIKE RECEPTORS IN INNATE IMMUNITY
    Stefanie Vogel; Fiscal Year: 2005
    ....
  37. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  38. Immune Evasion
    Giorgio Trinchieri; Fiscal Year: 2004
    ..We have attempted to cover many aspects of immune evasion in cancer as well as to provide examples of the importance of similar mechanisms in autoimmunity, transplantation, and pregnancy. ..
  39. EARLY ENDOTOXIN TOLERANCE: CELLULAR/MOLECULAR MECHANISMS
    Stefanie Vogel; Fiscal Year: 2004
    ..It is expected that, at the conclusion of this research, the mechanism of endotoxin tolerance and its potential impact on disease outcome in both sepsis and other diseases will be better understood. ..
  40. Ab5 Toxins Nasal Adjuvant Target the Olfactory Bulbs/CNS
    Kohtaro Fujihashi; Fiscal Year: 2004
    ..These proposed studies will provide essential new information to determine potential side effects of CT-B derivatives as nasal adjuvants, and point to ways where these toxic effects can be avoided. ..
  41. ANTIGEN PRESENTATION BY CLASS IB MOLECULE, QA-1
    James Forman; Fiscal Year: 2004
    ..If this occurs, we will then examine the processing and presentation of these viral encoded Qdm epitopes. ..
  42. ACTIVATED MUTANTS AS PROBES OF GM-CSF RECEPTOR FUNCTION
    RICHARD D ANDREA; Fiscal Year: 2003
    ..In addition, it is proposed that novel reagents (eg. monoclonal antibodies) can be generated which interact with critical regions of hbetac and can trigger signalling activity in the absence of cytokine. ..
  43. GUT FLORA AS A PROVOCATEUR OF AUTOIMMUNE COLITIS
    Peter Felsburg; Fiscal Year: 2002
    ..In addition, the ability of pathogenic T cells to cause or promote tissue injury through the production of toxic or inflammatory cytokines will also be investigated. ..
  44. LEISHMANIA INFECTION IN BALB/C IL4 NEG AND IL4R NEG MICE
    Nancy Noben Trauth; Fiscal Year: 2002
    ..major parasites and will offer alternative theories to the Th1/Th2 paradigm in general. These studies also will lead to new interpretations of the action of anti-IL-4 treatment in vivo. ..
  45. CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITY
    Kohtaro Fujihashi; Fiscal Year: 2005
    ..The seminal findings which have emanated from this grant effort since 1982 will again remain focused on the cellular and molecular events required for induction of mucosal immunity or oral tolerance in the GI tract. ..
  46. The Cytoskeleton, Rafts and the Interleukin-2 Receptor
    Jens Goebel; Fiscal Year: 2005
    ..abstract_text> ..
  47. Genes that Mediate Tolerance to the Placental Allograft
    Bruce Beutler; Fiscal Year: 2006
    ..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
  48. IMMUNE ESCAPE MECHANISMS IN LEISHMANASIS
    Imtiaz Khan; Fiscal Year: 2006
    ..These studies have implications for the development of therapies and vaccines directed toward Leishmania infections as well as the mechanisms that regulate Th1/Th2 cytokine development in vivo. ..
  49. Spondyloarthritis 2006; The Unmet Needs
    John Reveille; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  50. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
    ..abstract_text> ..
  51. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  52. NALT-BASED ADJUVANTS FOR MUCOSAL IMMUNITY IN AGING
    Kohtaro Fujihashi; Fiscal Year: 2010
    ....
  53. Maturation of Non-Specific Airways Reactivity
    Michael Grunstein; Fiscal Year: 2007
    ....
  54. Regulation of Type I Interferon Gene Expression in the Innate Immune Response
    Katherine A Fitzgerald; Fiscal Year: 2010
    ..abstract_text> ..
  55. Evaluate the antiangiogenic properties of mda-7/IL-24
    Rajagopal Ramesh; Fiscal Year: 2006
    ..abstract_text> ..
  56. Forward Genetic Analysis of the Innate Immune Contribution to MCMV Resistance
    Bruce Beutler; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  57. Mutagenic analysis of LPS responses
    Bruce Beutler; Fiscal Year: 2006
    ..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
  58. Oncogenes involved in acute myeloid leukemia development
    GARY REUTHER; Fiscal Year: 2007
    ..In summary, this proposal provides an excellent opportunity for the candidate to complete his training to become an independent researcher. ..
  59. IL-6 and early Th2 commitment
    Yaozhong Ding; Fiscal Year: 2009
    ..abstract_text> ..
  60. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  61. INNATE IMMUNITY
    Siamon Gordon; Fiscal Year: 2005
    ..The meeting will conclude with examples of how disorders of innate immunity can give rise to important diseases. ..
  62. FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITIS
    John Reveille; Fiscal Year: 2003
    ..abstract_text> ..