Genomes and Genes
Summary: Cell surface proteins that bind interleukins and trigger intracellular changes influencing the behavior of cells.
Publications259 found, 100 shown here
- Interleukin-13: central mediator of allergic asthmaM Wills-Karp
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
Science 282:2258-61. 1998..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...
- Requirement for IL-13 independently of IL-4 in experimental asthmaG Grunig
Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
Science 282:2261-3. 1998..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
- Interleukin-10 and the interleukin-10 receptorK W Moore
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
Annu Rev Immunol 19:683-765. 2001..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
- Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cellsS J Szabo
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 185:817-24. 1997..Thus, IFN-gamma may prevent early Th cells from premature commitment to the Th2 pathway. Controlling the expression of the IL-12R beta 2 subunit could be an important therapeutic target for the redirection of ongoing Th cell responses...
- Interleukin-17 family and IL-17 receptorsT A Moseley
Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
Cytokine Growth Factor Rev 14:155-74. 2003..This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues...
- Interleukin-18 regulates both Th1 and Th2 responsesK Nakanishi
Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
Annu Rev Immunol 19:423-74. 2001..Therefore, the functions of IL-18 in vivo are very heterogeneous and complicated. In principle, IL-18 enhances the IL-12-driven Th1 immune responses, but it can also stimulate Th2 immune responses in the absence of IL-12...
- Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defenseP Ye
Louisiana State University Health Sciences Gene Therapy Program, Section of Pulmonary Critical Care Medicine, New Orleans, LA 70112, USA
J Exp Med 194:519-27. 2001..pneumoniae infection. These data support impaired IL-17R signaling as a potential mechanism by which deficiency of CD4 lymphocytes predisposes to bacterial pneumonia...
- IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokinesJochen Schmitz
Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
Immunity 23:479-90. 2005..In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs...
- IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivoVirginie Carriere
Laboratoire de Biologie Vasculaire, Equipe Labellisée La Ligue 2006, Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse, France
Proc Natl Acad Sci U S A 104:282-7. 2007..Together, these data suggest that, similarly to IL1alpha and HMGB1, IL-33 is a dual function protein that may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties...
- Phenotypic and functional features of human Th17 cellsFrancesco Annunziato
Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
J Exp Med 204:1849-61. 2007....
- IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathwaysA M O'Farrell
Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA 94304 1104, USA
EMBO J 17:1006-18. 1998..Thus signals mediating both anti-proliferative and macrophage de-activation responses to IL-10 require the two membrane-distal tyrosines of IL-10R, but Stat3 appears to function only in the anti-proliferative response...
- Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantationL Robb
Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Victoria, Australia
Nat Med 4:303-8. 1998..These observations reveal a previously unrecognized critical role for IL-11 signaling in female reproduction...
- A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23RChristi Parham
Department of Immunology, DNAX Research, Palo Alto, CA 94304, USA
J Immunol 168:5699-708. 2002..The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12Rbeta2, respectively. The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12Rbeta2...
- Interleukin-17 family members and inflammationJay K Kolls
Division of Pulmonology, Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, PA, USA
Immunity 21:467-76. 2004..Increasing evidence shows that IL-17 family members play an active role in inflammatory diseases, autoimmune diseases, and cancer. This places IL-17 family members and their receptors as potential targets for future pharmacotherapy...
- Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytesM Watanabe
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
J Clin Invest 95:2945-53. 1995..These findings suggest that human intestinal epithelial cells and epithelial goblet cells produce IL-7, and locally produced IL-7 may serve as a potent regulatory factor for intestinal mucosal lymphocytes...
- Role of T-bet in commitment of TH1 cells before IL-12-dependent selectionA C Mullen
Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
Science 292:1907-10. 2001..These results suggest that a cytokine does not simply induce TH fate choice but instead may act as an essential secondary stimulus that mediates selective survival of a lineage...
- IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1J Lee
Department of Molecular Biology, Genentech Inc, San Francisco, California 94080, USA
J Biol Chem 276:1660-4. 2001..IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8...
- Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cellsJ T Chang
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 189:969-78. 1999..These results suggest that the development of immunotherapies that target the IL-12Rbeta2 subunit may be useful for the treatment of autoimmune diseases...
- IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complexAlissa A Chackerian
Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, CA 94304, USA
J Immunol 179:2551-5. 2007..The implications of this shared usage of IL-1RAcP by IL-1(alpha and beta) and IL-33 are discussed...
- Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancyIrma Airoldi
Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
Blood 106:3846-53. 2005..The development of autoimmunity, lymphoproliferation, and B-cell tumors in Il12rb2 knockout (KO) mice suggests that IL-12 functions physiologically to restrain aberrant B-cell activation...
- Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patientsKeiko Yamazaki
Laboratory for Gastrointestinal Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Kanagawa, Japan
J Hum Genet 52:575-83. 2007..Further genetic studies are required to confirm our findings with ethnically divergent populations...
- Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene inductionAlan C Mullen
Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
Nat Immunol 3:652-8. 2002..These findings suggest that heritable states of gene expression might be maintained by continued expression of the inducing factor or by a mechanism that confers a stable imprint of the induced state...
- IL-31: a new link between T cells and pruritus in atopic skin inflammationEniko Sonkoly
Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
J Allergy Clin Immunol 117:411-7. 2006..IL-31 is a novel T-cell-derived cytokine that induces severe pruritus and dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL-31 receptor A and oncostatin M receptor...
- Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in miceStacey R Dillon
Department of Immunology, ZymoGenetics, 1201 Eastlake Avenue East, Seattle, Washington 98102, USA
Nat Immunol 5:752-60. 2004..These data indicate that IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases...
- Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cellsXiang Yue Zhang
Department of Microbiology and Etiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
Immunogenetics 57:934-43. 2006....
- IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggsM G Chiaramonte
Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
J Immunol 162:920-30. 1999..Together, these data demonstrate that IL-13 serves as an important mediator of Th2-mediated inflammation and plays a role in eliciting IgE responses triggered by schistosome eggs...
- IL-12 and IL-23: master regulators of innate and adaptive immunityClaire L Langrish
Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
Immunol Rev 202:96-105. 2004..These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression...
- Interleukin 7 receptor-deficient mice lack gammadelta T cellsK Maki
Department of Disease Related Gene Regulation Research Sandoz Faculty of Medicine, The Univerisity of Tokyo, Japan
Proc Natl Acad Sci U S A 93:7172-7. 1996..On the contrary, it is suggested that NK-cell development requires cytokine(s) other than IL-7...
- The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12H Himmelrich
World Health Organization Immunology Research and Training Center, Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
J Immunol 161:6156-63. 1998..major is primarily based on an up-regulation of IL-4 production, which secondarily induces extinction of IL-12 signaling...
- Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding siteK Josephson
Center for Macromolecular Crystallography, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Immunity 15:35-46. 2001..The data suggests that formation of the active IL-10 signaling complex occurs by a novel molecular recognition paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on IL-10...
- TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionLiang Zhou
The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Nature 453:236-40. 2008..Therefore, the decision of antigen-stimulated cells to differentiate into either T(H)17 or T(reg) cells depends on the cytokine-regulated balance of RORgammat and Foxp3...
- Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient miceJ J Peschon
Immunex Research and Development Corporation, Seattle, Washington 98101
J Exp Med 180:1955-60. 1994..Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7...
- Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signalingT L Born
Immunex Corporation, Seattle, Washington 98101, USA
J Biol Chem 273:29445-50. 1998..We propose that although IL-1R-rp1 binds the cytokine, IL-1R-rp1 and AcPL proteins are both required for IL-18 signaling, analogous to the requirement for both IL-1R and IL-1RAcP in IL-1-mediated responses...
- Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune responseMonica G Chiaramonte
Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 197:687-701. 2003..Together, these studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response...
- GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-betTakashi Usui
Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 18:415-28. 2003..These findings reassert that Stat4 signaling is a central element of Th1/Th2 development...
- IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitisJanine Bilsborough
Department of Autoimmunity and Inflammation, ZymoGenetics, Inc, Seattle, WA 98102, USA
J Allergy Clin Immunol 117:418-25. 2006..IL-31 is a newly discovered T-cell cytokine that, when overexpressed in mice, results in pruritus and skin dermatitis resembling human atopic dermatitis (AD)...
- The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivoMandy J McGeachy
Schering Plough Biopharma, Palo Alto, California 94304, USA
Nat Immunol 10:314-24. 2009..These defects were associated with less proliferation; consequently, fewer effector T(H)-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues...
- Interleukin-12 in infectious diseasesL Romani
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
Clin Microbiol Rev 10:611-36. 1997..Continued investigation into the possible application of IL-12 therapy to human infections is warranted by the role of the cytokine in inflammation, immunopathology, and autoimmunity...
- Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variantsPaul R Burton
Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
Nat Genet 39:1329-37. 2007....
- Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cellsMarieke A Hoeve
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Eur J Immunol 36:661-70. 2006....
- Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instabilityZ Mallat
Institut National de la Sante et de la Recherche Medicale, INSERM U541, Institut Fédératif de Recherche Circulation Paris VII, Hopital Lariboisiere, Paris, France
Circulation 104:1598-603. 2001..Interleukin (IL)-18 is a potent proinflammatory cytokine with potential atherogenic properties. Its expression and role in atherosclerosis, however, are unknown...
- Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cellsDavid Moulin
Division of Rheumatology, University Hospital, University of Geneva School of Medicine, 26 Avenue Beau Sejour, 1211, Geneva 14, Switzerland
Cytokine 40:216-25. 2007..These findings open new perspectives for the treatment of inflammatory diseases by targeting IL-33...
- Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathologyLucia E Rosas
Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
Am J Pathol 168:158-69. 2006..Additionally, the data demonstrate that although the IL-27/TCCR interaction limits the severity of liver inflammation during VL by controlling CD4(+) T-cell activity, it is not required for the resolution of hepatic immunopathology...
- Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1Brandi C Jones
Center for Biophysical Sciences and Engineering, Department of Microbiology, University of Alabama, 1025 18th Street South, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 99:9404-9. 2002..Our results suggest cmvIL-10 and ebvIL-10 have evolved different molecular mechanisms to engage the IL-10 receptors that ultimately enhance the respective ability of their virus to escape immune detection...
- In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokinesFranck J Barrat
DNAX Research Institute, Department of Immunology, Palo Alto, CA 94304, USA
J Exp Med 195:603-16. 2002..Generating homogeneous populations of IL-10-producing T cells in vitro will thus facilitate the use of regulatory T cells in immunotherapy...
- A genome-wide association study identifies IL23R as an inflammatory bowel disease geneRichard H Duerr
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Science 314:1461-3. 2006..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease...
- cDNA cloning and characterization of the human interleukin 13 receptor alpha chainM J Aman
Laboratory of Molecular Immunology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
J Biol Chem 271:29265-70. 1996..Nevertheless, the overall size and length of the cytoplasmic domain of IL-13Ralpha and gammac are similar, and like gammac, IL-13Ralpha is located on chromosome X...
- Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine familyH Li
Department of Molecular Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Proc Natl Acad Sci U S A 97:773-8. 2000..These data show that there is a family of IL-17-related cytokines differing in patterns of expression and proinflammatory responses that may be transduced through a cognate set of cell surface receptors...
- IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel diseaseMark Tremelling
IBD Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge, England, UK
Gastroenterology 132:1657-64. 2007..We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15...
- Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriolJohn Rømer
Discovery, Novo Nordisk, Bagsvaerd, Denmark
J Invest Dermatol 121:1306-11. 2003..These findings show that IL-19 and IL-20 are synthesized by a distinct population of keratinocytes. It remains to be clarified whether IL-19 and IL-20 are implicated in the pathogenesis of psoriasis...
- Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chainsJ G Zhang
Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Victoria 3050, Australia
J Biol Chem 272:9474-80. 1997..Finally, unlike the cloned receptor, the IL-13BP acts as a potent inhibitor of IL-13 binding to its cell surface receptor, raising the possibility that it may be used to modulate the effects of IL-13 in vivo...
- A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma productionM Neighbors
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Incorporated, Palo Alto, CA 94304, USA
J Exp Med 194:343-54. 2001..Therefore, IL-18 operates via its effects on both the innate immune response, including macrophages, as well as on Th1 cells, to protect against Listeria...
- Contribution of activated interleukin receptors in trigeminal ganglion neurons to hyperalgesia via satellite glial interleukin-1beta paracrine mechanismMamoru Takeda
Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, Tokyo 102 8159, Japan
Brain Behav Immun 22:1016-23. 2008..Such an IL-1beta release could be important in determining trigeminal inflammatory hyperalgesia...
- Defective lymphoid development in mice lacking Jak3T Nosaka
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Science 270:800-2. 1995..Thus, Jak3 plays a critical role in gamma c signaling and lymphoid development...
- Investigation of association of the IL12B and IL23R genes with psoriatic arthritisCharlotte Filer
University of Manchester, Manchester, UK
Arthritis Rheum 58:3705-9. 2008..The aim of this study was to determine whether these variants are also associated with susceptibility to psoriatic arthritis (PsA)...
- Differential IL-10R1 expression plays a critical role in IL-10-mediated immune regulationY Ding
Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Immunol 167:6884-92. 2001..Modulation of cell surface IL-10R1 density might be an important mechanism for determining whether IL-10 leads to immunostimulation or immunosuppression in vivo...
- Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complexB Miloux
Sanofi Recherche, Labege Innopole, France
FEBS Lett 401:163-6. 1997..Electrophoretic mobility shift assay showed that IL-13 and IL-4 were able to activate Stat6 in cells expressing both IL-4R alpha and IL-13R alpha1, while no activation was observed in cells expressing either one or the other alone...
- Interferon-gamma-inducing activity of interleukin-18 in the joint with rheumatoid arthritisM Yamamura
Department of Medicine III, Okayama University Medical School, Japan
Arthritis Rheum 44:275-85. 2001..Detection of significant IL-18 bioactivity in the joints, despite the presence of IL-18 binding inhibitors, supports an integral role of this cytokine in perpetuating the IFNgamma-dominant T cell cytokine response in RA...
- Is there an interaction between interleukin-10 and interleukin-22?K Wolk
Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, D 10117 Berlin, Germany
Genes Immun 6:8-18. 2005..However, IL-10R2 interacted with defined IL-10- and IL-22-derived peptides supporting the hypothesis that cytokine binding to its corresponding R1 chain creates a binding site on this cytokine for IL-10R2...
- Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterizationMarehalli L Nagalakshmi
Department of Experimental Pathology and Pharmacology, DNAX Research Inc, 901 California Avenue, Palo Alto, CA 94304 1104, USA
Int Immunopharmacol 4:577-92. 2004..These data point to a function of the novel IL-10 family members in communication and interaction between cells of the hematopoietic and non-hematopoietic lineages, a role quite distinct from the immunomodulating effects of IL-10 itself...
- Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancerDominik Haudenschild
Center for Tissue Regeneration and Repair and Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
J Biol Chem 277:4309-16. 2002..Using antibodies directed at the cytoplasmic and extracellular domains of this protein, we investigated its localization and found that it was expressed in a variety of normal human tissues including prostate and in prostate cancer...
- The role of IL-18 in innate immunityS Akira
Department of Host Defense, CREST of Japan Science and Technology Corporation, Research Institute for Microbial Diseases, Osaka University, Suita, 565 0871, Japan
Curr Opin Immunol 12:59-63. 2000..The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response...
- The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitorsD R Moritz
Department of Pathology, University Hospital Zurich, Switzerland
J Immunol 161:4866-74. 1998....
- Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironmentMarcin Kortylewski
Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA
Cancer Cell 15:114-23. 2009..These results demonstrate that Stat3 promotes IL-23-mediated procarcinogenic immune responses while inhibiting IL-12-dependent antitumor immunity...
- Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanismW Ouyang
Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
Immunity 9:745-55. 1998..Thus, GATA-3 expression and IL-12 signaling are mutually antagonistic, which facilitates rapid dominance of one pathway during early Th development, producing a stable divergence in cytokine profiles...
- Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gammaA Zdanov
Macromolecular Structure Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
Structure 3:591-601. 1995..An atomic model is necessary to interpret biological activity of IL-10 and to design mutants with agonistic or antagonistic properties...
- IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sitesC Wu
Department of Inflammation Autoimmune Diseases, Hoffmann LaRoche, Nutley, NJ 07110, USA
J Immunol 165:6221-8. 2000..These results demonstrate that although mouse IL-12R beta 1 is the subunit primarily responsible for binding IL-12, IL-12R beta 2 plays an essential role in mediating the biological functions of IL-12 in mice...
- A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genesMichele Cargill
Celera, Alameda, CA 94502, USA
Am J Hum Genet 80:273-90. 2007..These data, and the previous observation that administration of an antibody specific for the IL-12p40 subunit to patients with psoriasis is highly efficacious, suggest that these genes play a fundamental role in psoriasis pathogenesis...
- T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responsesM J Townsend
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
J Exp Med 191:1069-76. 2000..These data clearly demonstrate that T1/ST2 expression plays a role in the development of Th2-like cytokine responses and indicate that effector functions are inhibited in its absence...
- Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosisF Altare
Laboratoire de Genetique Humaine des Maladies Infectieuses, Universite Rene Descartes, INSERM U550, Faculte de Medecine Necker, Paris, France
J Infect Dis 184:231-6. 2001..A diagnosis of IL-12Rbeta1 deficiency should therefore be considered in selected patients with severe tuberculosis, despite their resistance to BCG and a lack of atypical mycobacteriosis...
- Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptorA E Corcoran
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
Nature 391:904-7. 1998..This mechanism augments the recombinational diversity of the primary antibody repertoire...
- Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domelessS Brown
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
Curr Biol 11:1700-5. 2001..Like many interleukin receptors, DOME has a cytokine binding homology module (CBM) and three extracellular fibronectin-type-III domains (..
- T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector functionM Lohning
Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
Proc Natl Acad Sci U S A 95:6930-5. 1998..Administration of either a mAb against T1/ST2 or recombinant T1/ST2 fusion protein attenuates eosinophilic inflammation of the airways and suppresses IL-4 and IL-5 production in vivo following adoptive transfer of Th2 cells...
- Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieuK Nakanishi
Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
Cytokine Growth Factor Rev 12:53-72. 2001..Moreover, IL-18 also induces IL-13 and/or IL-4 production by NK cells, mast cells and basophils. Therefore, IL-18 should be seen as a unique cytokine that enhances innate immunity and both Th1- and Th2-driven immune responses...
- Crystal structure of interleukin 10 reveals an interferon gamma-like foldM R Walter
Department of Pharmacology, University of Alabama at Birmingham 35294, USA
Biochemistry 34:12118-25. 1995..Interleukin 10 and IFN-gamma contain several conserved residues in their internal cores which suggest a possible "fingerprint" for detection of other members of this fold...
- Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transductionD J Hilton
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria
EMBO J 13:4765-75. 1994..The expression of both NR1 and gp130 was also necessary for Ba/F3 cells to proliferate and M1 cells to undergo macrophage differentiation in response to IL-11...
- IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cellsT Sareneva
Department of Virology, National Public Health Institute, Helsinki, Finland
J Immunol 165:1933-8. 2000..In conclusion, the results suggest that IFN-alpha and IL-12 enhance innate as well as Th1 immune response by inducing IL-18R expression...
- Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responsesA J Coyle
Department of Biology, Inflammation Division, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
J Exp Med 190:895-902. 1999..Taken together, our data demonstrate an important role of T1/ST2 in Th2-mediated inflammatory responses and suggest that T1/ST2 may prove to be a novel target for the selective suppression of Th2 immune responses...
- Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptorM Noguchi
Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Science 262:1877-80. 1993..These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma...
- Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chainD Caput
Sanofi Recherche, BP 137, 31676 Labège Cedex, France
J Biol Chem 271:16921-6. 1996..Reverse transcription-polymerase chain reaction analysis detected the receptor transcript only in cell lines known to bind IL-13...
- Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutivelyM Takagi
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304
J Exp Med 181:889-99. 1995..These results strongly suggest that the lineage specificity of IL-5 is mainly due to the restricted expression of IL-5R alpha...
- A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gammaMichael O Daines
Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Biol Chem 277:10387-93. 2002..These results provide the first evidence that the IL-13Ralpha2 is predominantly an intracellular molecule and demonstrate a novel mechanism by which IFN-gamma can regulate IL-13 responses...
- IL-4 and IL-13 receptors: are they one and the same?R E Callard
Immunobiology Unit, Institute of Child Health, London, UK
Immunol Today 17:108-10. 1996..Indeed, as discussed here by Robin Callard and colleagues, the IL-13 receptor appears to be a functional receptor for IL-4...
- IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18R Debets
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304 1104, USA
J Immunol 165:4950-6. 2000....
- Missense mutation of the interleukin-12 receptor beta1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infectionT Sakai
Department of Immunopathophysiology and Internal Medicine II, Kumamoto University School of Medicine, Japan
Blood 97:2688-94. 2001....
- The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathwayK Kawakami
Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA
Blood 97:2673-9. 2001..Taken together, these observations indicate that internalization of IL-13Ralpha2 is signal independent and that this property of IL-13Ralpha2 can be exploited for receptor-directed cancer therapy...
- A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease lociYing Liu
Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS Genet 4:e1000041. 2008..This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis)...
- Human interleukin-19 and its receptor: a potential role in the induction of Th2 responsesGrant Gallagher
Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Room C 636, MSB, 185 South Orange Avenue, Newark, NJ 07103, USA
Int Immunopharmacol 4:615-26. 2004..Furthermore, in whole PBMC cultures, IL-19 up-regulated IL-4 and down-regulated IFNgamma in a dose-dependent manner. These results are presented here in review format, in the context of an overall discussion of IL-19 and its receptor...
- Cell-cell contact of human T cells with fibroblasts changes lymphocytic mRNA expression: increased mRNA expression of interleukin-17 and interleukin-17 receptorK Thiele
Institute of Medical Immunology, Martin Luther University Halle Wittenberg, Strasse der OdF 6, D 06097 Halle, Germany
Eur Cytokine Netw 11:53-8. 2000..Changes in the mRNA levels of Jurkat T cells induced by cell-cell contact with adherent cells were also found for M-type pyruvate kinase, for tropomyosin TM30 and for the p54nrb gene product...
- Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in miceP Bilinski
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
Genes Dev 12:2234-43. 1998..Therefore, IL-11Ralpha signaling at the implantation site appears to be required for decidua development...
- T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cellsMaryam Afkarian
Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
Nat Immunol 3:549-57. 2002..Thus, T-bet is induced by IFN-gamma and STAT1 signaling during T cell activation. In addition, T-bet mediates STAT1-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2...
- Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domainR M Weber-Nordt
Center for Immunology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 271:27954-61. 1996....
- Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexesS V Kotenko
Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
J Biol Chem 276:2725-32. 2001....
- Interleukin 5 regulates the isoform expression of its own receptor alpha-subunitJ Tavernier
Flanders Interuniversity Institute for Biotechnology and Department of Respiratory Diseases, University of Ghent, Belgium
Blood 95:1600-7. 2000..Blood. 2000;95:1600-1607)..
- Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptorA Zdanov
Macromolecular Structure Laboratory, NCI Frederick Cancer Research and Development Center, ABL Basic Research Program, Frederick, Maryland 21702, USA
Protein Sci 5:1955-62. 1996..The contact region between the cytokine and each receptor shows excellent complementarity of polar and hydrophobic interactions, suggesting that the model is generally correct and should be useful in guiding mutagenesis experiments...
- Involvement of p59fynT in interleukin-5 receptor signalingM W Appleby
Howard Hughes Medical Institute, Seattle, Washington 98195, USA
J Exp Med 182:811-20. 1995..Our results document the importance of p59fynT in IL-5 responses in B cells, and they support a general model for cytokine receptor signal transduction involving the simultaneous recruitment of at least three families of PTK...
- Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancerK Kawakami
Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
Cancer Res 61:6194-200. 2001..c. in nude mice. These results demonstrate that by using a combination approach of gene transfer and systemic or locoregional cytotoxin therapy, the IL-13R represents a new potent target for head and neck cancer therapy...
- Interleukin-11 signals through the formation of a hexameric receptor complexV A Barton
Cancer Research Campaign Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
J Biol Chem 275:36197-203. 2000..We therefore propose that IL-11 forms a hexameric receptor complex composed of two molecules each of IL-11, IL-11R, and gp130...
- Clinical and genetic heterogeneity of inherited autosomal recessive susceptibility to disseminated Mycobacterium bovis bacille calmette-guérin infectionHouda Elloumi-Zghal
Laboratoire d Immunologie, Vaccinologie, et Génétique Moléculaire, Institut Pasteur de Tunis, Tunis, Tunisia
J Infect Dis 185:1468-75. 2002..The clinical severity of the mycobacterial infection was heterogeneous, even among affected members of the same family, which suggests the intervention of modifying genes...
- A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSFJ Tavernier
Roche Research Gent, Belgium
Cell 66:1175-84. 1991....
- Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chainX Cao
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
Immunity 2:223-38. 1995..These mice provide an important model for studying the pathophysiology provide an important model for studying the pathophysiology of and gene therapy for human XSCID...
- Resolution of inflammation in healing myocardial infarctsNikolaos G Frangogiannis; Fiscal Year: 2013..In addition, the novel effects of IRAK-M on fibroblast function and its potential interactions with the TGF- [unreadable] pathway have important implications in the biology of tissue inflammation and repair. ..
- Molecular Mechanisms of Axon DegenerationMarc R Freeman; Fiscal Year: 2013....
- Synthetic TIR Domain Mimetics as a Novel Strategy for Intervention in SepsisJulius Rebek; Fiscal Year: 2010..A collection of molecules will be synthesized, tested in cell lines and optimized for their activity in the treatment of sepsis in appropriate animal models. ..
- The BCL-2 Homologues of Gamma HerpesvirusesJ Marie Hardwick; Fiscal Year: 2006..more open reading frames with recognizable homology to such cellular factors as chemokines, interleukins, interleukin receptors, cyclin, FLIP and BCL-2...
- REGULATION OF CELL ACTIVATION BY FATTY ACIDSROBERT ZURIER; Fiscal Year: 2000..in vitro and in vivo; studies will include determinations of interleukin-1 converting enzyme, the interleukin receptors, and the interleukin-1 receptor antagonist...
- DISCOVERY OF SMALL-MOLECULE MODULATORS OF IL-10 RECEPTORHuw Nash; Fiscal Year: 2000..be applied to other high-value drug targets which work by similar mechanisms, such as interferon and other interleukin receptors. PROPOSED COMMERCIAL APPLICATIONS: This project will develop a small-molecule antagonist of interleukin-10,..
- SELECTIVE EXPRESSION OF AGM1 DURING LYMPHOPOIESISRobert Stout; Fiscal Year: 1990..Early events in activation include the expression of interleukin receptors and apparently of the aGml glycolipid. It is not known how early expression of aGml occurs...
- Characterization of the IL-TIF Receptor ComplexSergei Kotenko; Fiscal Year: 2005..The long-term goal of this project is to obtain new knowledge that will improve our understanding of mechanisms that regulate proper functioning of the immune system. ..
- Role of Interferon-lambda in Antiviral ResponseSergei Kotenko; Fiscal Year: 2009..abstract_text> ..
- HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPYHenry Murray; Fiscal Year: 2005..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
- Host Immunoregulation of Response to Antileishmanial ChemotherapyHenry Murray; Fiscal Year: 2007..abstract_text> ..
- Asthma Positional Candidate Genes in Mice and HumansMarsha Wills Karp; Fiscal Year: 2010..abstract_text> ..
- Ad-mda7 plus Herceptin against Breast CancerSunil Chada; Fiscal Year: 2002..This strategy, if successful, could be further applied in human breast cancer trials. ..
- Mechanisms: IL-13 Induced Mucus Hypersecretion in AsthmaMarsha Wills Karp; Fiscal Year: 2006..A better understanding of the mechanisms underlying IL-13-induced mucus hypersecretion should guide the development of novel strategies for the treatment of asthma and other hypersecretory diseases of the lung. ..
- Nanoparticles for the Treatment of Lung CancerMingzhong Zheng; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- IDENTIFYING MAJOR SUSCEPTIBILITY GENES OF IBDJUDY CHO; Fiscal Year: 2003..Once risk alleles are identified in multiplex families, characterization of the nature and broad significance of specific risk alleles for IBD in a variety of populations will be performed. ..
- Mapping Chromosome 3q Inflammatory Bowel Disease GenesJUDY CHO; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- The Natural History of Pediatric Crohn's DiseaseMarla Dubinsky; Fiscal Year: 2008..abstract_text> ..
- IL-10 Receptor Signaling That Regulates Innate ImmunityRobert Schreiber; Fiscal Year: 2008....
- Virus-Induced Mechanics of Altered Airway ResponsivenessMichael Grunstein; Fiscal Year: 2008..It is anticipated that the findings from these proposed studies would yield important new insights into the mechanistic interplay between viral respiratory pathogens, atopy, and altered airway responsiveness. [unreadable] [unreadable]..
- Lineage decision in blood stem and progenitor cellsKoichi Akashi; Fiscal Year: 2007..Thus, we hope these studies will help understand mechanistic effects of these transcription factors on lineage decision in normal and malignant hematopoietic development. ..
- TLR4 as an LPS sendor and susceptibility locusBruce Beutler; Fiscal Year: 2007..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
- ANK and Joint Ankylosis in SpondylitisRobert Terkeltaub; Fiscal Year: 2008..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
- Mechanisms and Consequences of Toll Like Receptor Signal TransductionStefanie Vogel; Fiscal Year: 2008..3) Assess the mechanism of TLR tyrosine phosphorylation and its functional consequences. ..
- The Molecular and Cellular Basis of Cancer ImmunoeditingRobert Schreiber; Fiscal Year: 2008..This work will provide the first molecular and mechanistic insights into the cancer immunoediting process and may also establish molecular guidelines to judge the extent to which a tumor has been edited. ..
- IL-10 Regulation of Lymphangiogenesis in Prostate CancerMark Stearns; Fiscal Year: 2008..Overall, the studies should demonstrate whether the IL-10R axis and down stream effector genes (and specifically IL-10S1-VEGF D, and VEGF D) play a pivotal role in lymphangiogenesis and/or angiogenesis processes. ..
- Fibroproliferation in Bronchiolitis Obliterans SyndromeVibha Lama; Fiscal Year: 2008..Martinez MD, MS and Marc Peters-Golden MD, both of whom are well-funded researchers with a long track record of mentoring. ..
- ADENOVIRUS FLT3 LIGAND INDUCES NALT DCs FOR SALIVARY GLAND S-lgA Ab RESPONSESKohtaro Fujihashi; Fiscal Year: 2010..4) Determination of the precise mechanism for cross-talk between Ad-FL-induced salivary DCs, B-1 B cells and yS T cells for salivary S-lgA Ab responses. ..
- Parental Expression of Immune Responses In Pediatric Crohn's DiseaseMarla Dubinsky; Fiscal Year: 2008..unreadable] [unreadable]..
- Chondrocyte S100/Calgranulins and RAGE in OsteoarthritisRobert Terkeltaub; Fiscal Year: 2009..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
- Conference Proposal: Transplantation ImmunologyAngus Thomson; Fiscal Year: 2004..An important goal will be evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research. ..
- IMMUNE POTENTIAL OF ANIMAL LACKING CLASS IA MOLECULESJAMES M FORMAN; Fiscal Year: 2010..In summary, this proposal will add important new information on how CDS T cells function in the innate immune response against intracellular pathogens. ..
- SIGNAL TRANSDUCTION IN SENSITIZED AIRWAY SMOOTH MUSCLEMichael Grunstein; Fiscal Year: 2002....
- IL10 and IGF1 Receptor Axis in Prostate CancerMark Stearns; Fiscal Year: 2005..Development of therapeutic agents, which target the IL-10R or IGF-R1 axis should be beneficial in the treatment of the disease. ..
- Conference:Cytokines, Disease & Therapeutic InterventionMary Collins; Fiscal Year: 2004..abstract_text> ..
- ROLES OF TOLL LIKE RECEPTORS IN INNATE IMMUNITYStefanie Vogel; Fiscal Year: 2005....
- PTHRP 1 to 173 IN CHONDROCYTESRobert Terkeltaub; Fiscal Year: 2005..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
- Immune EvasionGiorgio Trinchieri; Fiscal Year: 2004..We have attempted to cover many aspects of immune evasion in cancer as well as to provide examples of the importance of similar mechanisms in autoimmunity, transplantation, and pregnancy. ..
- EARLY ENDOTOXIN TOLERANCE: CELLULAR/MOLECULAR MECHANISMSStefanie Vogel; Fiscal Year: 2004..It is expected that, at the conclusion of this research, the mechanism of endotoxin tolerance and its potential impact on disease outcome in both sepsis and other diseases will be better understood. ..
- Ab5 Toxins Nasal Adjuvant Target the Olfactory Bulbs/CNSKohtaro Fujihashi; Fiscal Year: 2004..These proposed studies will provide essential new information to determine potential side effects of CT-B derivatives as nasal adjuvants, and point to ways where these toxic effects can be avoided. ..
- ANTIGEN PRESENTATION BY CLASS IB MOLECULE, QA-1James Forman; Fiscal Year: 2004..If this occurs, we will then examine the processing and presentation of these viral encoded Qdm epitopes. ..
- ACTIVATED MUTANTS AS PROBES OF GM-CSF RECEPTOR FUNCTIONRICHARD D ANDREA; Fiscal Year: 2003..In addition, it is proposed that novel reagents (eg. monoclonal antibodies) can be generated which interact with critical regions of hbetac and can trigger signalling activity in the absence of cytokine. ..
- GUT FLORA AS A PROVOCATEUR OF AUTOIMMUNE COLITISPeter Felsburg; Fiscal Year: 2002..In addition, the ability of pathogenic T cells to cause or promote tissue injury through the production of toxic or inflammatory cytokines will also be investigated. ..
- LEISHMANIA INFECTION IN BALB/C IL4 NEG AND IL4R NEG MICENancy Noben Trauth; Fiscal Year: 2002..major parasites and will offer alternative theories to the Th1/Th2 paradigm in general. These studies also will lead to new interpretations of the action of anti-IL-4 treatment in vivo. ..
- CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITYKohtaro Fujihashi; Fiscal Year: 2005..The seminal findings which have emanated from this grant effort since 1982 will again remain focused on the cellular and molecular events required for induction of mucosal immunity or oral tolerance in the GI tract. ..
- The Cytoskeleton, Rafts and the Interleukin-2 ReceptorJens Goebel; Fiscal Year: 2005..abstract_text> ..
- Genes that Mediate Tolerance to the Placental AllograftBruce Beutler; Fiscal Year: 2006..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
- IMMUNE ESCAPE MECHANISMS IN LEISHMANASISImtiaz Khan; Fiscal Year: 2006..These studies have implications for the development of therapies and vaccines directed toward Leishmania infections as well as the mechanisms that regulate Th1/Th2 cytokine development in vivo. ..
- Spondyloarthritis 2006; The Unmet NeedsJohn Reveille; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Innate immune responses in lymphatic filariasisAMY HISE; Fiscal Year: 2007..abstract_text> ..
- Chemokines, nitric oxide, and myocardial depressionBysani Chandrasekar; Fiscal Year: 2005..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
- NALT-BASED ADJUVANTS FOR MUCOSAL IMMUNITY IN AGINGKohtaro Fujihashi; Fiscal Year: 2010....
- Maturation of Non-Specific Airways ReactivityMichael Grunstein; Fiscal Year: 2007....
- Regulation of Type I Interferon Gene Expression in the Innate Immune ResponseKatherine A Fitzgerald; Fiscal Year: 2010..abstract_text> ..
- Evaluate the antiangiogenic properties of mda-7/IL-24Rajagopal Ramesh; Fiscal Year: 2006..abstract_text> ..
- Forward Genetic Analysis of the Innate Immune Contribution to MCMV ResistanceBruce Beutler; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Mutagenic analysis of LPS responsesBruce Beutler; Fiscal Year: 2006..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
- Oncogenes involved in acute myeloid leukemia developmentGARY REUTHER; Fiscal Year: 2007..In summary, this proposal provides an excellent opportunity for the candidate to complete his training to become an independent researcher. ..
- IL-6 and early Th2 commitmentYaozhong Ding; Fiscal Year: 2009..abstract_text> ..
- CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMINGHal Broxmeyer; Fiscal Year: 2005..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
- INNATE IMMUNITYSiamon Gordon; Fiscal Year: 2005..The meeting will conclude with examples of how disorders of innate immunity can give rise to important diseases. ..
- FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITISJohn Reveille; Fiscal Year: 2003..abstract_text> ..