erythropoietin receptors

Summary

Summary: Cell surface proteins that bind erythropoietin with high affinity and trigger intracellular changes influencing the behavior of cells.

Top Publications

  1. ncbi Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    M L Brines
    The Kenneth S Warren Laboratories, 765 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 97:10526-31. 2000
  2. ncbi Anti-Epo receptor antibodies do not predict Epo receptor expression
    Steve Elliott
    Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA 91320, USA
    Blood 107:1892-5. 2006
  3. ncbi Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    H Wu
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Cell 83:59-67. 1995
  4. ncbi Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin
    Joan C Egrie
    Amgen Inc, Thousand Oaks, Calif 91320, USA
    Exp Hematol 31:290-9. 2003
  5. ncbi The role of erythropoietin in regulating angiogenesis
    Nathalie Kertesz
    Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA, 90095 1735, USA
    Dev Biol 276:101-10. 2004
  6. ncbi The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
    L J Huang
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 8:1327-38. 2001
  7. ncbi JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    B A Witthuhn
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 74:227-36. 1993
  8. ncbi Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia
    Rita Sulahian
    Departments of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 75390 9039, USA
    Blood 113:5287-97. 2009
  9. ncbi Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation
    Didier Bouscary
    , Institut Cochin, , Centre National de la Recherche Scientifique, UMR 8104, , Paris, France
    Blood 101:3436-43. 2003
  10. ncbi Erythropoietin receptor signalling is required for normal brain development
    Xiaobing Yu
    Laboratory of Chemical Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 129:505-16. 2002

Research Grants

  1. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2009
  2. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2010
  3. IN VIVO SIGNALING OF THE ERYTHROPOIETIN RECEPTOR
    Saghi Ghaffari; Fiscal Year: 2002
  4. Erythropoietin receptor /Janus Kinase 2 complex
    Lily Huang; Fiscal Year: 2006
  5. ERYTHROPOIETIN RECEPTOR REGULATION OF ERYTHROPOIESIS
    MURAT ARCASOY; Fiscal Year: 2002
  6. Molecular Biology of Polycythemia
    Josef Prchal; Fiscal Year: 2007
  7. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
  8. Characterization of a Novel Erythropoietin Signaling Pathway
    Adam N Goldfarb; Fiscal Year: 2010
  9. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2010
  10. Role of NIX in Erythroid Maturation
    PAUL NEY; Fiscal Year: 2007

Detail Information

Publications191 found, 100 shown here

  1. ncbi Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    M L Brines
    The Kenneth S Warren Laboratories, 765 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 97:10526-31. 2000
    ..Given r-Hu-EPO's excellent safety profile, clinical trials evaluating systemically administered r-Hu-EPO as a general neuroprotective treatment are warranted...
  2. ncbi Anti-Epo receptor antibodies do not predict Epo receptor expression
    Steve Elliott
    Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA 91320, USA
    Blood 107:1892-5. 2006
    ..We concluded that these antibodies have limited utility for detecting EpoR. Thus, reports of EpoR expression in tumor cells using these antibodies should be viewed with caution...
  3. ncbi Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    H Wu
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Cell 83:59-67. 1995
    ..EPO and the EPOR are crucial in vivo for the proliferation and survival of CFU-E progenitors and their irreversible terminal differentiation...
  4. ncbi Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin
    Joan C Egrie
    Amgen Inc, Thousand Oaks, Calif 91320, USA
    Exp Hematol 31:290-9. 2003
    ..Darbepoetin alfa, a hyperglycosylated recombinant human EPO (rHuEPO) analogue with two extra carbohydrate chains, was designed and developed to test this hypothesis...
  5. ncbi The role of erythropoietin in regulating angiogenesis
    Nathalie Kertesz
    Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA, 90095 1735, USA
    Dev Biol 276:101-10. 2004
    ..Moreover, Ang-1 expression is regulated by EPO/EPOR under normoxic conditions. Taken together, our results suggest important roles of EPO and EPOR in angiogenesis...
  6. ncbi The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
    L J Huang
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 8:1327-38. 2001
    ..Thus, in addition to its kinase activity required for cytokine receptor signaling, JAK is also an essential subunit required for surface expression of cytokine receptors...
  7. ncbi JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    B A Witthuhn
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 74:227-36. 1993
    ..The results support the hypothesis that JAK2 is the kinase that couples EPO binding to tyrosine phosphorylation and mitogenesis...
  8. ncbi Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia
    Rita Sulahian
    Departments of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 75390 9039, USA
    Blood 113:5287-97. 2009
    ....
  9. ncbi Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation
    Didier Bouscary
    , Institut Cochin, , Centre National de la Recherche Scientifique, UMR 8104, , Paris, France
    Blood 101:3436-43. 2003
    ....
  10. ncbi Erythropoietin receptor signalling is required for normal brain development
    Xiaobing Yu
    Laboratory of Chemical Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 129:505-16. 2002
    ..5 in the developing brain, and that induction of erythropoietin and its receptor by hypoxia may contribute to selective cell survival in the brain...
  11. ncbi Efficiency of signalling through cytokine receptors depends critically on receptor orientation
    R S Syed
    Amgen Inc, Thousand Oaks, California 91320 1789, USA
    Nature 395:511-6. 1998
    ..It activates cells by binding and orientating two cell-surface erythropoietin receptors (EPORs) which trigger an intracellular phosphorylation cascade...
  12. ncbi Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia
    Monica Fantacci
    Department of Medicine, University of Milan, San Paolo Hospital, Milan 20142, Italy
    Proc Natl Acad Sci U S A 103:17531-6. 2006
    ..These observations therefore demonstrate that CEpo administration reduces the metabolic stress caused by severe CH, resulting in improved cellular survival independent of erythrocyte production...
  13. ncbi Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle
    Carsten Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 3, 2100 Copenhagen Ø, Denmark
    J Appl Physiol 104:1154-60. 2008
    ..However, in contrast to our hypothesis, prolonged Epo administration had no apparent effect on capillarization or muscle fiber hypertrophy...
  14. ncbi Erythropoietin and erythropoietin receptor expression in human cancer
    G Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:3561-5. 2001
    ..Hypoxic tumor regions display the highest levels of EPO and EPOR expression. Enhanced EPO signaling may contribute to the promotion of human cancer by tissue hypoxia...
  15. ncbi Erythropoietin receptors: their role beyond erythropoiesis
    Jerome Rossert
    Nephrol Dial Transplant 20:1025-8. 2005
  16. ncbi Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway
    H Chin
    First Department of Internal Medicine and School of Allied Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Blood 91:3734-45. 1998
    ..In addition, Lyn was demonstrated to phosphorylate the EpoR and Stat5 on tyrosines in vitro. These results suggest that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpoR...
  17. ncbi Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis
    M von Lindern
    Institute of Hematology, Erasmus Medical Centre Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Oncogene 20:3651-64. 2001
    ..However, while v-ErbB transformed cells and normal progenitors depended on PI3K signaling for renewal, c-ErbB also induces progenitor expansion by PI3K-independent mechanisms...
  18. ncbi Erythropoietin improves functional and histological recovery of traumatized skeletal muscle tissue
    Robert Rotter
    Department of Trauma and Reconstructive Surgery, University of Rostock, 18055 Rostock, Germany
    J Orthop Res 26:1618-26. 2008
    ..Thus, EPO, a compound established as clinically safe, may represent a promising therapeutic option to optimize the posttraumatic course of muscle tissue healing...
  19. ncbi Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
    U Klingmuller
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 80:729-38. 1995
    ..Our results suggest that activation of SH-PTP1 by binding to the EPO-R plays a major role in terminating proliferative signals...
  20. ncbi Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality
    Norio Suzuki
    Center for Tsukuba Advanced Research Alliance, Institutes of Basic Medical Sciences and Clinical Medicine, University of Tsukuba, Tokyo, Japan
    Blood 100:2279-88. 2002
    ..We thus conclude that nonhematopoietic expression of EpoR is dispensable to normal mouse development and that the expression level of EpoR regulates erythropoiesis by controlling the sensitivity of erythroid progenitors to Epo...
  21. ncbi Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout the life span
    Pascal E Sanchez
    Universite de Lyon, Lyon, France
    J Comp Neurol 514:403-14. 2009
    ..Given that Epo protects extended populations of neurons after injury, a yet-to-be-identified receptor heterocomplex including Epo-R may exist in the large population of brain neurons that does not express betac...
  22. ncbi Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts
    M Socolovsky
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Blood 98:3261-73. 2001
    ..Decreased expression of bcl-x(L) and increased apoptosis in Stat5a(-/-)5b(-/-) early erythroblasts correlate with the degree of anemia. Hence, Stat5 controls a rate-determining step regulating early erythroblast survival...
  23. ncbi Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy
    Daisuke Watanabe
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    N Engl J Med 353:782-92. 2005
    ..CONCLUSIONS: Our data suggest that erythropoietin is a potent ischemia-induced angiogenic factor that acts independently of VEGF during retinal angiogenesis in proliferative diabetic retinopathy...
  24. ncbi beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation
    Laure Meyer
    Institut Cochin, Departement d Hematologie, Paris, France
    Blood 109:5215-22. 2007
    ....
  25. ncbi Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model
    Karsten Ruscher
    Department of Experimental Neurology, Charite Hospital, Humboldt University, D 10098 Berlin, Germany
    J Neurosci 22:10291-301. 2002
    ..PI3K deactivates BAD via Akt-mediated phosphorylation and thus may inhibit hypoxia-induced apoptosis in neurons. Our results establish EPO as an important paracrine neuroprotective mediator of ischemic preconditioning...
  26. ncbi The cellular biology of erythropoietin receptors
    Terry Lappin
    Queen s University Belfast, Belfast City Hospital, Belfast, Northern Ireland
    Oncologist 8:15-8. 2003
    ..Organs such as the brain, ovary, oviduct, uterus, and testis have erythropoietin receptors. Because erythropoietin receptors exist in the paracrine and autocrine systems, as well as the hormonal ..
  27. ncbi Signal transduction in the erythropoietin receptor system
    D M Wojchowski
    Program in Cell and Developmental Biology, Pennsylvania State University, University Park, Pennsylvania, 16802, USA
    Exp Cell Res 253:143-56. 1999
    ....
  28. ncbi Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemia
    T Motohashi
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba and CREST JST, Tsukuba, Ibaraki, Japan
    Eur J Haematol 67:88-93. 2001
    ....
  29. ncbi Derivatives of erythropoietin that are tissue protective but not erythropoietic
    Marcel Leist
    H. Lundbeck A/S, 2500 Valby, Denmark
    Science 305:239-42. 2004
    ....
  30. ncbi Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades
    M Digicaylioglu
    Center for Neuroscience and Aging Research, The Burnham Institute, La Jolla, CA 92037, USA
    Nature 412:641-7. 2001
    ..Thus neuronal EPORs activate a neuroprotective pathway that is distinct from previously well characterized Jak and NF-kappaB functions. Moreover, this EPO effect may underlie neuroprotection mediated by hypoxic-ischaemic preconditioning...
  31. ncbi Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells
    S Masuda
    Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
    J Biol Chem 268:11208-16. 1993
    ..The addition of Epo to the culture media of PC12 cells elevated the intracellular concentrations of monoamines...
  32. ncbi Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor
    Michael Brines
    Kenneth S Warren Institute, Ossining, NY 10563, USA
    Proc Natl Acad Sci U S A 101:14907-12. 2004
    ..These data support the concept that EpoR and betacR comprise a tissue-protective heteroreceptor...
  33. ncbi Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture
    A Nagai
    Department of Medicine, University of British Columbia, Vancouver, Canada
    J Neuropathol Exp Neurol 60:386-92. 2001
    ..These results suggest that proinflammatory cytokines regulate expression of EPO and EPOR in human neurons, astrocytes, and microglia and further facilitate interactions among different cell types in the human CNS...
  34. ncbi A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    A Yoshimura
    Cancer Research Institute, Faculty of Medicine, Kagoshima University, Japan
    EMBO J 14:2816-26. 1995
    ..Thus CIS appears to be a unique regulatory molecule for cytokine signal transduction...
  35. ncbi Prognostic significance of erythropoietin expression in human endometrial carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer 100:2376-86. 2004
    ..The authors recently demonstrated hypoxia-stimulated expression of Epo and Epo receptor (EpoR) in human breast and cervical carcinomas, suggesting a role for autocrine Epo signaling in the hypoxic adaptations of carcinomas...
  36. ncbi Familial and congenital polycythemias: a diagnostic approach
    Tom Van Maerken
    Department of Pediatric Hematology-Oncology, University Hospital Ghent, Belgium
    J Pediatr Hematol Oncol 26:407-16. 2004
    ..In this article the authors describe a child with primary FCP, review the different FCPs, and propose an adapted work-up scheme...
  37. ncbi Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 162:1789-806. 2003
    ..Hypoxia-inducible Epo signaling may play a significant role in the aggressive behavior and treatment resistance of hypoxic cervical cancers...
  38. ncbi Erythropoietin stimulates growth and STAT5 phosphorylation in human prostate epithelial and prostate cancer cells
    Laurie Feldman
    Laboratory for Cell and Molecular Biology, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Prostate 66:135-45. 2006
    ..EpoR have been identified on a variety of non-hematopoietic cells, both normal and malignant, however, little is known about the function of EpoR on malignant cells...
  39. ncbi Integrative signaling by minimal erythropoietin receptor forms and c-Kit
    T J Pircher
    Department of Veterinary Science, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 276:8995-9002. 2001
    ..Thus, integration circuits exist in only select downstream pathways within Epo and stem call factor receptor signaling...
  40. ncbi The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis
    H Zang
    Department of Biochemistry and Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 20:3156-66. 2001
    ..The results demonstrate that neither the distal region nor receptor tyrosines are essential for in vivo EpoR function, but contribute to receptor function in a subtle manner...
  41. ncbi Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma
    Youn Soo Lee
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Cancer Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 11:1059-64. 2005
    ..Such arrest may lead to autocrine stimulation, cell proliferation, and renal tumor development, similar to tumorigenesis of VHL disease-associated hemangioblastomas...
  42. ncbi New avenues of exploration for erythropoietin
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    JAMA 293:90-5. 2005
    ....
  43. ncbi Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinoma
    Stuart C Winter
    Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford
    Clin Cancer Res 11:7614-20. 2005
    ..This study examines the protein and mRNA expression of erythropoietin and erythropoietin receptor in HNSCC and their relation to hypoxia, hemoglobin (Hb), and clinical outcome...
  44. ncbi Immunolocalization of erythropoietin and erythropoietin receptor in vestibular schwannoma
    D G Dillard
    Department of Otolaryngology, Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    Acta Otolaryngol 121:149-52. 2001
    ..Using immunohistochemistry, we have demonstrated that both EPO and EPO-R are expressed in a majority of these tumors...
  45. ncbi Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism
    Changmin Chen
    Harvard Med Sch, Boston, MA
    Blood 104:73-80. 2004
    ..These results indicate the presence of a Ras-independent mechanism for Raf-1 and MEK activation in these cells...
  46. ncbi Role of c-Kit and erythropoietin receptor in erythropoiesis
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Cancer Research Building, Indianapolis, IN 46202, USA
    Crit Rev Oncol Hematol 54:63-75. 2005
    ..This review summarizes recent advances made towards understanding the signaling mechanisms by which Epo-R and c-Kit regulate growth, survival, and differentiation of erythroid progenitors alone and cooperatively...
  47. ncbi Human, nonhuman primate, and rat pancreatic islets express erythropoietin receptors
    Elizabeth S Fenjves
    Diabetes Research Institute, University of Miami, School of Medicine, Miami, FL 33136, USA
    Transplantation 75:1356-60. 2003
    ..The authors examined pancreatic islets for the presence of EPO-R to determine whether these cells are protected by EPO from cytokine-induced apoptosis...
  48. ncbi Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor
    Bai Lin Tan
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:11686-95. 2003
    ..These data demonstrate an essential role for Src pathway in regulating growth, proliferation, and cooperation with Epo-R downstream from Kit...
  49. ncbi Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation
    Makoto Sugawa
    Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Company Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Neurosci Res 44:391-403. 2002
    ..These comprehensive effects of Epo might also affect the ability of oligodendrocyte lineage cells to promote myelin repair in the normal and damaged adult central nervous system...
  50. ncbi Both proteasomes and lysosomes degrade the activated erythropoietin receptor
    Pierre Walrafen
    Departement d Hematologie, Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, Paris, France
    Blood 105:600-8. 2005
    ..The efficiency of these processes probably explains the short duration of intracellular signaling activated by Epo...
  51. ncbi Erythropoietin regulates tumour growth of human malignancies
    Yoshiko Yasuda
    Department of Anatomy, Division 1, Kinki University School of Medicine, Osaka Sayama, Japan
    Carcinogenesis 24:1021-9. 2003
    ..These findings suggest that Epo is indispensable for the growth and viability of malignant tumour and also that the deprivation of Epo signalling may be a promising therapy for human malignancy...
  52. ncbi Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Cancer 95:969-81. 2002
    ....
  53. ncbi Expression of erythropoietin receptor splice variants in human cancer
    Murat O Arcasoy
    Department of Medicine, Division of Hematology Medical Oncology, Duke University School of Medicine, DUMC Box 3912, Durham, NC 27710, USA
    Biochem Biophys Res Commun 307:999-1007. 2003
    ..These findings indicate the expression of multiple EPOR isoforms in human cancer cells that may modulate the cellular effects of recombinant human EPO or EPO-EPOR antagonists...
  54. ncbi Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury
    Anna K Junk
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:10659-64. 2002
    ..These results further establish EPO as a neuroprotective agent in acute neuronal ischemic injury...
  55. ncbi Detection and quantification of the soluble form of the human erythropoietin receptor (sEpoR) in the growth medium of tumor cell lines and in the plasma of blood samples
    G Westphal
    Division of Radiobiology and Radiooncology, German Cancer Research Center DKFZ, Heidelberg
    Clin Exp Med 2:45-52. 2002
    ..In conclusion, an ELISA to quantify the sEpoR was established and the expression of sEpoR in human tumor cell lines was demonstrated for the first time...
  56. ncbi Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis
    Suzanne Burns
    South Texas Veterans Health Care System, and Department of Medicine, Division of Hematology, University of Texas Health Science Center, San Antonio, TX, USA
    Blood 99:4400-5. 2002
    ..Yeast-expressed Epo (R103A) is a specific inhibitor of primary erythropoiesis suitable for testing in animal models...
  57. ncbi Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit
    Ke Li
    Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 278:40702-9. 2003
    ..Instead, co-signaling appears to depend upon the downstream integration of Kit signals with the targets of an EpoR/Jak2/Y343/Stat 5 response axis...
  58. ncbi Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeability
    Ofelia María Martínez-Estrada
    Departament de Biologia Cel lular, Facultat Biologia, Universitat de Barcelona, E 08028 Barcelona, Spain
    Eur J Neurosci 18:2538-44. 2003
    ..Our results suggest a new mechanism for Epo-induced neuroprotection, in which circulating Epo controls and maintains the BBB through an Epo receptor signalling pathway and the re-establishment of cell junctions...
  59. ncbi Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn
    P A Tilbrook
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital, Australia
    Cancer Res 61:2453-8. 2001
    ..Taken together, these data show that Lyn plays an important role in intracellular signaling in nontransformed and leukemic erythroid cells...
  60. ncbi Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor-positive breast carcinoma models
    Kenneth R LaMontagne
    Drug Discovery, Growth Factors, Johnson and Johnson Pharmaceutical Research and Development, Room B354, OMP Building, 1000 Route 202, PO Box 300, Raritan, NJ 08869, USA
    Mol Cancer Ther 5:347-55. 2006
    ..These results show that recombinant epoetins do not evoke a physiologic response on EPOR-bearing tumor cells as assessed by numerous variables, including growth, migration, and cytotoxic challenge in preclinical in vivo tumor models...
  61. ncbi Advances in understanding the pathogenesis of primary familial and congenital polycythaemia
    Lily J Huang
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9039, USA
    Br J Haematol 148:844-52. 2010
    ..Truncated PFCP EpoRs are not properly down-regulated upon stimulation, underscoring the importance of these mechanisms in the pathogenesis of PFCP...
  62. ncbi Problems in identifying functional erythropoietin receptors in cancer tissue
    Wolfgang Jelkmann
    J Clin Oncol 25:1627-8; author reply 1628. 2007
  63. ncbi The non-haematopoietic biological effects of erythropoietin
    Murat O Arcasoy
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Br J Haematol 141:14-31. 2008
    ..This review focuses on the scientific evidence documenting the biological effects of Epo in non-haematopoietic tissues and discusses potential future applications of Epo and its derivatives in the clinic...
  64. ncbi Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment
    Michael I Assaraf
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    J Neuropathol Exp Neurol 66:389-98. 2007
    ..We conclude that upregulation of EpoR in temporal cortical and hippocampal astrocytes is an early, potentially neuroprotective, event in the pathogenesis of sporadic AD...
  65. ncbi Do cancer cells express functional erythropoietin receptors?
    Gregory D Longmore
    Washington University, St Louis, USA
    N Engl J Med 356:2447. 2007
  66. ncbi Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia
    Jorge Soliz
    Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland, and Center de Recherché, Hôpital St François d Assise, Quebec, Canada
    J Physiol 583:329-36. 2007
    ....
  67. ncbi Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia
    Raja El Hasnaoui-Saadani
    Universite Paris, Bobigny, France
    Am J Physiol Regul Integr Comp Physiol 296:R801-11. 2009
    ..levels of hypoxia-inducible factor 1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), erythropoietin receptors (EpoR), phospho-STAT-5/STAT-5 ratio, and neuronal neuronal nitric oxide synthase (nNOS) along with a ..
  68. ncbi Erythropoietin and renoprotection
    Ferdinand H Bahlmann
    Department of Internal Medicine IV, Saarland University Medical Centre, Homburg Saar, Germany
    Curr Opin Nephrol Hypertens 18:15-20. 2009
    ..Finally, we will review the current literature on clinical studies with rHuEPO or analogous substances and progression of chronic kidney disease, and propose possible clinical renoprotective strategies...
  69. ncbi A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene
    Maha Al-Sheikh
    INSERM, U841, Creteil, France
    Haematologica 93:1072-5. 2008
    ..6146A>G (p.Asn487Ser)] and another, a silent one (g.5799G>A). All were heterozygotes. In addition, 2 patients were positive for JAK2 (Val617Phe), and 2 reported elsewhere, were mutated in the PHD2 gene [c.606delG (p.Met202IlefsX71)...
  70. ncbi Activation of erythropoietin receptors by Friend viral gp55 and by erythropoietin and down-modulation by the murine Fv-2r resistance gene
    M E Hoatlin
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098
    Proc Natl Acad Sci U S A 87:9985-9. 1990
    ..leukemogenic membrane glycoprotein (gp55) encoded by Friend spleen focus-forming virus appears to bind to erythropoietin receptors (EpoR) sto stimulate erythroblastosis [Li, J.-P., D'Andrea, A.D., Lodish, H.F. & Baltimore, D...
  71. ncbi Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in Ba/F3 cells via the IL-3 receptor alpha subunit
    J Krosl
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    J Biol Chem 271:27432-7. 1996
    Introduction of erythropoietin receptors (EpoRs) into the interleukin-3 (IL-3)-dependent murine hemopoietic cell line, Ba/F3, enables these cells to not only proliferate, after an initial lag in G1, but also to increase beta-globin mRNA ..
  72. ncbi Erythropoietin receptors on tumor cells: what do they mean?
    Joachim Fandrey
    Institut fur Physiologie, Universitat Duisburg Essen, Hufelandstr 55, D 45147 Essen, Germany
    Oncologist 13:16-20. 2008
    Given the apparent presence of erythropoietin receptors (EPORs) in cancer tissues, questions have been raised about the possible influence of erythropoiesis-stimulating agents (ESAs) on tumor growth and proliferation...
  73. ncbi Cell surface site for mitogenic interaction of erythropoietin receptors with the membrane glycoprotein encoded by Friend erythroleukemia virus
    F E Ferro
    Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health Sciences University, Portland 97201 3098
    J Biol Chem 268:5741-7. 1993
    ..Recent evidence suggested that gp55 binds to erythropoietin receptors (EpoR) in the RER, and it was proposed that this intracellular interaction causes mitogenesis (Li, J.-P...
  74. ncbi Human erythropoietin receptor: cloning, expression, and biologic characterization
    S S Jones
    Genetics Institute, Cambridge, MA 02140
    Blood 76:31-5. 1990
    ..The murine interleukin-3-dependent pre-B-lymphocyte cell line, Ba/F3, was made EPO-dependent by transfection of the human cDNA into the cells and selecting for growth in EPO-containing media...
  75. ncbi An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: a cytokine receptor superfamily oncogene
    G D Longmore
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
    Cell 67:1089-102. 1991
    ..The activated erythropoietin receptor does not transform cultured fibroblasts, suggesting why oncogenic mutations in other members of this receptor superfamily have not been detected...
  76. ncbi Isolation of a cDNA encoding a potential soluble receptor for human erythropoietin
    K Todokoro
    Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Gene 106:283-4. 1991
    ..Analysis of human erythropoietin receptor-encoding cDNAs revealed the possible existence of a soluble receptor lacking the transmembrane and cytoplasmic domains...
  77. ncbi Erythropoietin stimulates proliferation of human renal carcinoma cells
    C Westenfelder
    Division of Nephrology, Veterans Administration and University of Utah Medical Centers, Salt Lake City 84148, USA
    Kidney Int 58:647-57. 2000
    ..The present study examines whether EPO could elicit such a proliferative and thereby potentially detrimental response in cells of human renal-cell carcinoma (RCC)...
  78. ncbi The intron 5-inserted form of rat erythropoietin receptor is expressed as a membrane-bound form
    R Yamaji
    Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Biochim Biophys Acta 1403:169-78. 1998
    ....
  79. ncbi Inactivation of erythropoietin leads to defects in cardiac morphogenesis
    H Wu
    Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA 90095 1735, USA
    Development 126:3597-605. 1999
    ....
  80. ncbi Erythropoietin receptor expression in human melanoma cells
    E Selzer
    Department of Radiotherapy and Radiobiology, University Hospital, Vienna, Austria
    Melanoma Res 10:421-6. 2000
    ..This observation might be useful in the early diagnosis of melanoma...
  81. ncbi Preclinical studies of erythropoietin receptor expression in tumour cells: impact on clinical use of erythropoietic proteins to correct cancer-related anaemia
    Anders Osterborg
    Department of Oncology, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Cancer 43:510-9. 2007
    ..Together with diverging results in the literature, these methodological limitations indicate that findings from preclinical studies must not be over-translated in terms of their clinical relevance to patients with cancer...
  82. ncbi The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p
    J C Winkelmann
    Department of Medicine, University of Minnesota, Minneapolis
    Blood 76:24-30. 1990
    ..The human Epo receptor gene is localized to human chromosome 19p by in situ hybridization. This chromosome assignment is confirmed by hybridization to a panel of sorted human chromosomes...
  83. ncbi Biology of erythropoietin
    C Lacombe
    Institut National de la Sante et de la Recherche Medicale, Unité 363, ICGM, Universite Rene Descartes, Paris, France
    Haematologica 83:724-32. 1998
    ..Furthermore, target disruption of both Epo and Epo receptor showed that Epo was not involved in the commitment of the erythroid lineage and seemed to act mainly as a survival factor...
  84. ncbi Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia
    R Kralovics
    University of Alabama at Birmingham, Division of Hematology Oncology, Birmingham, Alabama 35294 0006, USA
    J Clin Invest 102:124-9. 1998
    ..Failure of this child to develop polycythemia suggests the existence of as yet unidentified environmental or genetic factors that may suppress disease development...
  85. ncbi Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function
    Stephane Pelletier
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell Biol 26:8527-38. 2006
    ..Collectively, the results suggest that Jak2 is the sole direct signaling molecule downstream of EpoR required for biological activity...
  86. ncbi Impaired erythropoiesis after haemorrhagic shock in mice is associated with erythroid progenitor apoptosis in vivo
    Y Robinson
    Centre for Trauma and Reconstructive Surgery, Charite Campus Benjamin Franklin, Berlin, Germany
    Acta Anaesthesiol Scand 52:605-13. 2008
    ..Therefore, the underlying mechanisms were investigated in bone marrow (BM) and peripheral blood in a murine resuscitated haemorrhagic shock (HS) model...
  87. ncbi Erythropoiesis-stimulating agents: favorable safety profile when used as indicated
    Mohammad R Nowrousian
    Department of Internal Medicine Cancer Research, West German Cancer Center, University Hospital Essen, Germany
    Strahlenther Onkol 184:121-36. 2008
    ..Several studies with erythropoiesis-stimulating agents (ESAs) have raised a number of safety issues. Therefore, a discussion of available data in light of the current EORTC guidelines 2006 on the use of ESAs in anemic patients is warranted...
  88. ncbi Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma
    Adrienne Halupa
    Division of Stem Cell and Developmetal Biology, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Exp Cell Res 309:1-11. 2005
    ..Hence, we have identified a novel adapter function for PLCgamma1 in EPO signaling in which recruitment of PLCgamma1 to EPO-R may lead to activation of the ERK pathway...
  89. ncbi Turning cells red: signal transduction mediated by erythropoietin
    Terri D Richmond
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada
    Trends Cell Biol 15:146-55. 2005
    ..In this review, we summarize EPO-mediated signaling pathways and examine their significance in vivo...
  90. ncbi Erythropoietin: new approaches to improved molecular designs and therapeutic alternatives
    N Debeljak
    Center for Functional Genomics and Bio Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Zaloska 4, SI 1000 Ljubljana, Slovenia
    Curr Pharm Des 14:1302-10. 2008
    ..The demonstration that Epo can trigger signaling in some cancer cells with, potentially, adverse effects on patient health has raised warning signs in the medical community and has gained the attention of regulatory authorities...
  91. ncbi Pleiotropic functions of erythropoietin
    Ryuzo Sasaki
    Department of Life Style Studies, School of Human Cultures, The University of Shiga, Shiga
    Intern Med 42:142-9. 2003
    ..The uterine EPO is likely involved in the estrogen-dependent angiogenesis of the endometrial layer. The possible functions of EPO in other tissues and tissue-characteristic regulation of EPO production are also discussed in this review...
  92. ncbi Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
    Wei Tong
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Blood 105:4604-12. 2005
    ..Hence, Lnk, through its SH2 domain, negatively modulates EpoR signaling by attenuating JAK2 activation, and regulates Epo-mediated erythropoiesis...
  93. ncbi Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2
    Ulkan Kilic
    Department of Neurology, University Hospital Zurich, Switzerland
    FASEB J 19:249-51. 2005
    ....
  94. ncbi Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival
    Waheed Sangrar
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Exp Hematol 32:935-45. 2004
    ..In this study we wished to determine if Fps/Fes also plays a role in the regulation of erythropoiesis...
  95. ncbi The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation
    Taghi Manshouri
    Department of Leukemia, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Sci 99:1265-73. 2008
    ..Flow cytometric analysis of expanded PV progenitor cells treated with CP-690,550 suggests a possible transition towards a pattern of erythroid differentiation resembling expanded cells from normal healthy controls...
  96. ncbi Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
    Jorge P Pinto
    Iron Genes and Immune System, Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal
    Blood 111:5727-33. 2008
    ....
  97. ncbi Expression of EPO receptor in pancreatic cells and its effect on cell apoptosis
    Hongxia Shuai
    Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 28:49-51. 2008
    ..From these findings, it was concluded that EPOR was expressed in NIT-1 cells and EPO could protect NIT-1 cells from apoptosis induced by cytokines...
  98. ncbi Functional conservation of erythropoietin signaling in zebrafish
    Noelle Paffett-Lugassy
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 110:2718-26. 2007
    ..Together, the characterization of zebrafish epo and epor demonstrates the conservation of an ancient program that ensures proper red blood cell numbers during normal homeostasis and under hypoxic conditions...
  99. ncbi Erythropoietin receptor signal transduction requires protein geranylgeranylation
    Sumaya N Hamadmad
    Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Pharmacol Exp Ther 316:403-9. 2006
    ..These results indicate that protein geranylgeranylation and not farnesylation is important for proper Epo signal transduction...
  100. ncbi Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway
    Wei Zhao
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 107:907-15. 2006
    ..These data demonstrate that EpoR signaling phosphorylates GATA-1 and modulates its activity via the PI3-kinase/AKT signaling pathway...
  101. ncbi Erythropoietin biology in cancer
    Matthew E Hardee
    Department of Pathology, Duke University Medical Center, Durham, NC 22710, USA
    Clin Cancer Res 12:332-9. 2006
    ..This review describes Epo and EpoR biology, focusing on the pleiotropic effects of Epo on nonhematopoietic tissues as well as the expression and function of EpoR in cancer cells...

Research Grants79

  1. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2009
    ..These studies will have a critical impact on our understanding of mechanisms of different types of anemias and how to increase red blood cell production. ..
  2. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2010
    ..These studies will have a critical impact on our understanding of mechanisms of different types of anemias and how to increase red blood cell production. ..
  3. IN VIVO SIGNALING OF THE ERYTHROPOIETIN RECEPTOR
    Saghi Ghaffari; Fiscal Year: 2002
    ....
  4. Erythropoietin receptor /Janus Kinase 2 complex
    Lily Huang; Fiscal Year: 2006
    ..Through this research proposal, the applicant will receive training in biophysical and structural biology and will gain the necessary skills and knowledge to become an independent investigator. ..
  5. ERYTHROPOIETIN RECEPTOR REGULATION OF ERYTHROPOIESIS
    MURAT ARCASOY; Fiscal Year: 2002
    ....
  6. Molecular Biology of Polycythemia
    Josef Prchal; Fiscal Year: 2007
    ..Aim 3 Determine the genetic and molecular basis for congenital polycythemias characterized by elevated Epo concentrations and mutations of other than the VHL gene. ..
  7. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    b>Erythropoietin receptors are present on intestinal cells of the human fetus and neonate...
  8. Characterization of a Novel Erythropoietin Signaling Pathway
    Adam N Goldfarb; Fiscal Year: 2010
    ..One specific topic listed in this announcement is "Non-erythroid Expression and Function of Erythropoietin Receptors." A significant component of this project will be devoted to analysis of myocardial PKD activation by Epo ..
  9. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2010
    ..In addition, on the basis of these studies, we will continue to develop a novel protein engineering method to control biological processes, including infection by human immunodeficiency virus, an important co-factor in many cancers. ..
  10. Role of NIX in Erythroid Maturation
    PAUL NEY; Fiscal Year: 2007
    ..We propose to explore that possibility in experiments with Nix mice and other BCL2-related mouse strains. ..
  11. Fetal Stem Cell Gene Therapy
    MARCUS MUENCH; Fiscal Year: 2003
    ..A positive outcome from the proposed studies would aid in developing treatments for hemoglobinopathies based on generating hematopoietic allochimerism. ..
  12. Erythropoietin receptor signaling in erythropoiesis
    Lily Huang; Fiscal Year: 2009
    ..Information gained from these studies will lead to a more comprehensive understanding of how EpoR signaling regulates erythropoiesis and how oncogenic EpoR and JAK2 activation induces leukemia. ..
  13. Role of Erythropoietin receptor signaling in heart
    MURAT ARCASOY; Fiscal Year: 2004
    ..abstract_text> ..
  14. Erythropoietin Blockade for the Treatment of Cancer
    C Anthony Blau; Fiscal Year: 2010
    ..First, we will develop a diagnostic assay to predict which patients are most susceptible to erythropoietin induced tumor growth. Second, we propose a new strategy for treating tumors that is based on erythropoietin blockade. ..
  15. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara Miller; Fiscal Year: 2006
    ..TRPC2 knockout mice will be used to examine the rote of TRPC2 in viability, proliferation, apoptosis induction and cell cycle progression of primary erythroid cells. ..
  16. Erythropoietin Blockade for the Treatment of Cancer
    C Anthony Blau; Fiscal Year: 2009
    ..First, we will develop a diagnostic assay to predict which patients are most susceptible to erythropoietin induced tumor growth. Second, we propose a new strategy for treating tumors that is based on erythropoietin blockade. ..
  17. ROLE OF FV2 IN ERYTHROPOIESIS
    PAUL NEY; Fiscal Year: 2004
    ..These studies should improve our understanding of normal hematopoiesis and leukemic transformation. ..
  18. XRAY STUDIES OF EPO AND IL2 RECEPTOR COMPLEXES
    Ian Wilson; Fiscal Year: 2001
    ..The crystallographic study of IL-2 mutants and various forms of the receptor complex should give insights into the structure and function of this key receptor in T cell growth and proliferation. ..