Genomes and Genes
Summary: Cell surface proteins that bind erythropoietin with high affinity and trigger intracellular changes influencing the behavior of cells.
Publications191 found, 100 shown here
- Erythropoietin crosses the blood-brain barrier to protect against experimental brain injuryM L Brines
The Kenneth S Warren Laboratories, 765 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Proc Natl Acad Sci U S A 97:10526-31. 2000..Given r-Hu-EPO's excellent safety profile, clinical trials evaluating systemically administered r-Hu-EPO as a general neuroprotective treatment are warranted...
- Anti-Epo receptor antibodies do not predict Epo receptor expressionSteve Elliott
Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA 91320, USA
Blood 107:1892-5. 2006..We concluded that these antibodies have limited utility for detecting EpoR. Thus, reports of EpoR expression in tumor cells using these antibodies should be viewed with caution...
- Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptorH Wu
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Cell 83:59-67. 1995..EPO and the EPOR are crucial in vivo for the proliferation and survival of CFU-E progenitors and their irreversible terminal differentiation...
- Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietinJoan C Egrie
Amgen Inc, Thousand Oaks, Calif 91320, USA
Exp Hematol 31:290-9. 2003..Darbepoetin alfa, a hyperglycosylated recombinant human EPO (rHuEPO) analogue with two extra carbohydrate chains, was designed and developed to test this hypothesis...
- The role of erythropoietin in regulating angiogenesisNathalie Kertesz
Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA, 90095 1735, USA
Dev Biol 276:101-10. 2004..Moreover, Ang-1 expression is regulated by EPO/EPOR under normoxic conditions. Taken together, our results suggest important roles of EPO and EPOR in angiogenesis...
- The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptorL J Huang
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Mol Cell 8:1327-38. 2001..Thus, in addition to its kinase activity required for cytokine receptor signaling, JAK is also an essential subunit required for surface expression of cytokine receptors...
- JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietinB A Witthuhn
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
Cell 74:227-36. 1993..The results support the hypothesis that JAK2 is the kinase that couples EPO binding to tyrosine phosphorylation and mitogenesis...
- Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemiaRita Sulahian
Departments of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 75390 9039, USA
Blood 113:5287-97. 2009....
- Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferationDidier Bouscary
, Institut Cochin, , Centre National de la Recherche Scientifique, UMR 8104, , Paris, France
Blood 101:3436-43. 2003....
- Erythropoietin receptor signalling is required for normal brain developmentXiaobing Yu
Laboratory of Chemical Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
Development 129:505-16. 2002..5 in the developing brain, and that induction of erythropoietin and its receptor by hypoxia may contribute to selective cell survival in the brain...
- Efficiency of signalling through cytokine receptors depends critically on receptor orientationR S Syed
Amgen Inc, Thousand Oaks, California 91320 1789, USA
Nature 395:511-6. 1998..It activates cells by binding and orientating two cell-surface erythropoietin receptors (EPORs) which trigger an intracellular phosphorylation cascade...
- Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxiaMonica Fantacci
Department of Medicine, University of Milan, San Paolo Hospital, Milan 20142, Italy
Proc Natl Acad Sci U S A 103:17531-6. 2006..These observations therefore demonstrate that CEpo administration reduces the metabolic stress caused by severe CH, resulting in improved cellular survival independent of erythrocyte production...
- Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscleCarsten Lundby
Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 3, 2100 Copenhagen Ø, Denmark
J Appl Physiol 104:1154-60. 2008..However, in contrast to our hypothesis, prolonged Epo administration had no apparent effect on capillarization or muscle fiber hypertrophy...
- Erythropoietin and erythropoietin receptor expression in human cancerG Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Cancer Res 61:3561-5. 2001..Hypoxic tumor regions display the highest levels of EPO and EPOR expression. Enhanced EPO signaling may contribute to the promotion of human cancer by tissue hypoxia...
- Erythropoietin receptors: their role beyond erythropoiesisJerome Rossert
Nephrol Dial Transplant 20:1025-8. 2005
- Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathwayH Chin
First Department of Internal Medicine and School of Allied Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Blood 91:3734-45. 1998..In addition, Lyn was demonstrated to phosphorylate the EpoR and Stat5 on tyrosines in vitro. These results suggest that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpoR...
- Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesisM von Lindern
Institute of Hematology, Erasmus Medical Centre Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Oncogene 20:3651-64. 2001..However, while v-ErbB transformed cells and normal progenitors depended on PI3K signaling for renewal, c-ErbB also induces progenitor expansion by PI3K-independent mechanisms...
- Erythropoietin improves functional and histological recovery of traumatized skeletal muscle tissueRobert Rotter
Department of Trauma and Reconstructive Surgery, University of Rostock, 18055 Rostock, Germany
J Orthop Res 26:1618-26. 2008..Thus, EPO, a compound established as clinically safe, may represent a promising therapeutic option to optimize the posttraumatic course of muscle tissue healing...
- Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signalsU Klingmuller
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Cell 80:729-38. 1995..Our results suggest that activation of SH-PTP1 by binding to the EPO-R plays a major role in terminating proliferative signals...
- Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethalityNorio Suzuki
Center for Tsukuba Advanced Research Alliance, Institutes of Basic Medical Sciences and Clinical Medicine, University of Tsukuba, Tokyo, Japan
Blood 100:2279-88. 2002..We thus conclude that nonhematopoietic expression of EpoR is dispensable to normal mouse development and that the expression level of EpoR regulates erythropoiesis by controlling the sensitivity of erythroid progenitors to Epo...
- Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout the life spanPascal E Sanchez
Universite de Lyon, Lyon, France
J Comp Neurol 514:403-14. 2009..Given that Epo protects extended populations of neurons after injury, a yet-to-be-identified receptor heterocomplex including Epo-R may exist in the large population of brain neurons that does not express betac...
- Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblastsM Socolovsky
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Blood 98:3261-73. 2001..Decreased expression of bcl-x(L) and increased apoptosis in Stat5a(-/-)5b(-/-) early erythroblasts correlate with the degree of anemia. Hence, Stat5 controls a rate-determining step regulating early erythroblast survival...
- Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathyDaisuke Watanabe
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
N Engl J Med 353:782-92. 2005..CONCLUSIONS: Our data suggest that erythropoietin is a potent ischemia-induced angiogenic factor that acts independently of VEGF during retinal angiogenesis in proliferative diabetic retinopathy...
- beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferationLaure Meyer
Institut Cochin, Departement d Hematologie, Paris, France
Blood 109:5215-22. 2007....
- Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro modelKarsten Ruscher
Department of Experimental Neurology, Charite Hospital, Humboldt University, D 10098 Berlin, Germany
J Neurosci 22:10291-301. 2002..PI3K deactivates BAD via Akt-mediated phosphorylation and thus may inhibit hypoxia-induced apoptosis in neurons. Our results establish EPO as an important paracrine neuroprotective mediator of ischemic preconditioning...
- The cellular biology of erythropoietin receptorsTerry Lappin
Queen s University Belfast, Belfast City Hospital, Belfast, Northern Ireland
Oncologist 8:15-8. 2003..Organs such as the brain, ovary, oviduct, uterus, and testis have erythropoietin receptors. Because erythropoietin receptors exist in the paracrine and autocrine systems, as well as the hormonal ..
- Signal transduction in the erythropoietin receptor systemD M Wojchowski
Program in Cell and Developmental Biology, Pennsylvania State University, University Park, Pennsylvania, 16802, USA
Exp Cell Res 253:143-56. 1999....
- Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemiaT Motohashi
Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba and CREST JST, Tsukuba, Ibaraki, Japan
Eur J Haematol 67:88-93. 2001....
- Derivatives of erythropoietin that are tissue protective but not erythropoieticMarcel Leist
H. Lundbeck A/S, 2500 Valby, Denmark
Science 305:239-42. 2004....
- Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascadesM Digicaylioglu
Center for Neuroscience and Aging Research, The Burnham Institute, La Jolla, CA 92037, USA
Nature 412:641-7. 2001..Thus neuronal EPORs activate a neuroprotective pathway that is distinct from previously well characterized Jak and NF-kappaB functions. Moreover, this EPO effect may underlie neuroprotection mediated by hypoxic-ischaemic preconditioning...
- Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cellsS Masuda
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
J Biol Chem 268:11208-16. 1993..The addition of Epo to the culture media of PC12 cells elevated the intracellular concentrations of monoamines...
- Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptorMichael Brines
Kenneth S Warren Institute, Ossining, NY 10563, USA
Proc Natl Acad Sci U S A 101:14907-12. 2004..These data support the concept that EpoR and betacR comprise a tissue-protective heteroreceptor...
- Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in cultureA Nagai
Department of Medicine, University of British Columbia, Vancouver, Canada
J Neuropathol Exp Neurol 60:386-92. 2001..These results suggest that proinflammatory cytokines regulate expression of EPO and EPOR in human neurons, astrocytes, and microglia and further facilitate interactions among different cell types in the human CNS...
- A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptorsA Yoshimura
Cancer Research Institute, Faculty of Medicine, Kagoshima University, Japan
EMBO J 14:2816-26. 1995..Thus CIS appears to be a unique regulatory molecule for cytokine signal transduction...
- Prognostic significance of erythropoietin expression in human endometrial carcinomaGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Cancer 100:2376-86. 2004..The authors recently demonstrated hypoxia-stimulated expression of Epo and Epo receptor (EpoR) in human breast and cervical carcinomas, suggesting a role for autocrine Epo signaling in the hypoxic adaptations of carcinomas...
- Familial and congenital polycythemias: a diagnostic approachTom Van Maerken
Department of Pediatric Hematology-Oncology, University Hospital Ghent, Belgium
J Pediatr Hematol Oncol 26:407-16. 2004..In this article the authors describe a child with primary FCP, review the different FCPs, and propose an adapted work-up scheme...
- Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progressionGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Am J Pathol 162:1789-806. 2003..Hypoxia-inducible Epo signaling may play a significant role in the aggressive behavior and treatment resistance of hypoxic cervical cancers...
- Erythropoietin stimulates growth and STAT5 phosphorylation in human prostate epithelial and prostate cancer cellsLaurie Feldman
Laboratory for Cell and Molecular Biology, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Prostate 66:135-45. 2006..EpoR have been identified on a variety of non-hematopoietic cells, both normal and malignant, however, little is known about the function of EpoR on malignant cells...
- Integrative signaling by minimal erythropoietin receptor forms and c-KitT J Pircher
Department of Veterinary Science, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 276:8995-9002. 2001..Thus, integration circuits exist in only select downstream pathways within Epo and stem call factor receptor signaling...
- The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesisH Zang
Department of Biochemistry and Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, TN 38105, USA
EMBO J 20:3156-66. 2001..The results demonstrate that neither the distal region nor receptor tyrosines are essential for in vivo EpoR function, but contribute to receptor function in a subtle manner...
- Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinomaYoun Soo Lee
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Cancer Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
Clin Cancer Res 11:1059-64. 2005..Such arrest may lead to autocrine stimulation, cell proliferation, and renal tumor development, similar to tumorigenesis of VHL disease-associated hemangioblastomas...
- New avenues of exploration for erythropoietinKenneth Maiese
Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Mich 48201, USA
JAMA 293:90-5. 2005....
- Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinomaStuart C Winter
Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford
Clin Cancer Res 11:7614-20. 2005..This study examines the protein and mRNA expression of erythropoietin and erythropoietin receptor in HNSCC and their relation to hypoxia, hemoglobin (Hb), and clinical outcome...
- Immunolocalization of erythropoietin and erythropoietin receptor in vestibular schwannomaD G Dillard
Department of Otolaryngology, Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
Acta Otolaryngol 121:149-52. 2001..Using immunohistochemistry, we have demonstrated that both EPO and EPO-R are expressed in a majority of these tumors...
- Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanismChangmin Chen
Harvard Med Sch, Boston, MA
Blood 104:73-80. 2004..These results indicate the presence of a Ras-independent mechanism for Raf-1 and MEK activation in these cells...
- Role of c-Kit and erythropoietin receptor in erythropoiesisVeerendra Munugalavadla
Department of Pediatrics, Herman B Wells Center for Pediatric Research, Cancer Research Building, Indianapolis, IN 46202, USA
Crit Rev Oncol Hematol 54:63-75. 2005..This review summarizes recent advances made towards understanding the signaling mechanisms by which Epo-R and c-Kit regulate growth, survival, and differentiation of erythroid progenitors alone and cooperatively...
- Human, nonhuman primate, and rat pancreatic islets express erythropoietin receptorsElizabeth S Fenjves
Diabetes Research Institute, University of Miami, School of Medicine, Miami, FL 33136, USA
Transplantation 75:1356-60. 2003..The authors examined pancreatic islets for the presence of EPO-R to determine whether these cells are protected by EPO from cytokine-induced apoptosis...
- Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptorBai Lin Tan
Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Biol Chem 278:11686-95. 2003..These data demonstrate an essential role for Src pathway in regulating growth, proliferation, and cooperation with Epo-R downstream from Kit...
- Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferationMakoto Sugawa
Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Company Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
Neurosci Res 44:391-403. 2002..These comprehensive effects of Epo might also affect the ability of oligodendrocyte lineage cells to promote myelin repair in the normal and damaged adult central nervous system...
- Both proteasomes and lysosomes degrade the activated erythropoietin receptorPierre Walrafen
Departement d Hematologie, Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, Paris, France
Blood 105:600-8. 2005..The efficiency of these processes probably explains the short duration of intracellular signaling activated by Epo...
- Erythropoietin regulates tumour growth of human malignanciesYoshiko Yasuda
Department of Anatomy, Division 1, Kinki University School of Medicine, Osaka Sayama, Japan
Carcinogenesis 24:1021-9. 2003..These findings suggest that Epo is indispensable for the growth and viability of malignant tumour and also that the deprivation of Epo signalling may be a promising therapy for human malignancy...
- Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinomaGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
Cancer 95:969-81. 2002....
- Expression of erythropoietin receptor splice variants in human cancerMurat O Arcasoy
Department of Medicine, Division of Hematology Medical Oncology, Duke University School of Medicine, DUMC Box 3912, Durham, NC 27710, USA
Biochem Biophys Res Commun 307:999-1007. 2003..These findings indicate the expression of multiple EPOR isoforms in human cancer cells that may modulate the cellular effects of recombinant human EPO or EPO-EPOR antagonists...
- Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injuryAnna K Junk
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 99:10659-64. 2002..These results further establish EPO as a neuroprotective agent in acute neuronal ischemic injury...
- Detection and quantification of the soluble form of the human erythropoietin receptor (sEpoR) in the growth medium of tumor cell lines and in the plasma of blood samplesG Westphal
Division of Radiobiology and Radiooncology, German Cancer Research Center DKFZ, Heidelberg
Clin Exp Med 2:45-52. 2002..In conclusion, an ELISA to quantify the sEpoR was established and the expression of sEpoR in human tumor cell lines was demonstrated for the first time...
- Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesisSuzanne Burns
South Texas Veterans Health Care System, and Department of Medicine, Division of Hematology, University of Texas Health Science Center, San Antonio, TX, USA
Blood 99:4400-5. 2002..Yeast-expressed Epo (R103A) is a specific inhibitor of primary erythropoiesis suitable for testing in animal models...
- Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kitKe Li
Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 278:40702-9. 2003..Instead, co-signaling appears to depend upon the downstream integration of Kit signals with the targets of an EpoR/Jak2/Y343/Stat 5 response axis...
- Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeabilityOfelia María Martínez-Estrada
Departament de Biologia Cel lular, Facultat Biologia, Universitat de Barcelona, E 08028 Barcelona, Spain
Eur J Neurosci 18:2538-44. 2003..Our results suggest a new mechanism for Epo-induced neuroprotection, in which circulating Epo controls and maintains the BBB through an Epo receptor signalling pathway and the re-establishment of cell junctions...
- Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of LynP A Tilbrook
Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital, Australia
Cancer Res 61:2453-8. 2001..Taken together, these data show that Lyn plays an important role in intracellular signaling in nontransformed and leukemic erythroid cells...
- Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor-positive breast carcinoma modelsKenneth R LaMontagne
Drug Discovery, Growth Factors, Johnson and Johnson Pharmaceutical Research and Development, Room B354, OMP Building, 1000 Route 202, PO Box 300, Raritan, NJ 08869, USA
Mol Cancer Ther 5:347-55. 2006..These results show that recombinant epoetins do not evoke a physiologic response on EPOR-bearing tumor cells as assessed by numerous variables, including growth, migration, and cytotoxic challenge in preclinical in vivo tumor models...
- Advances in understanding the pathogenesis of primary familial and congenital polycythaemiaLily J Huang
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9039, USA
Br J Haematol 148:844-52. 2010..Truncated PFCP EpoRs are not properly down-regulated upon stimulation, underscoring the importance of these mechanisms in the pathogenesis of PFCP...
- Problems in identifying functional erythropoietin receptors in cancer tissueWolfgang Jelkmann
J Clin Oncol 25:1627-8; author reply 1628. 2007
- The non-haematopoietic biological effects of erythropoietinMurat O Arcasoy
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Br J Haematol 141:14-31. 2008..This review focuses on the scientific evidence documenting the biological effects of Epo in non-haematopoietic tissues and discusses potential future applications of Epo and its derivatives in the clinic...
- Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairmentMichael I Assaraf
Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
J Neuropathol Exp Neurol 66:389-98. 2007..We conclude that upregulation of EpoR in temporal cortical and hippocampal astrocytes is an early, potentially neuroprotective, event in the pathogenesis of sporadic AD...
- Do cancer cells express functional erythropoietin receptors?Gregory D Longmore
Washington University, St Louis, USA
N Engl J Med 356:2447. 2007
- Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxiaJorge Soliz
Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland, and Center de Recherché, Hôpital St François d Assise, Quebec, Canada
J Physiol 583:329-36. 2007....
- Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxiaRaja El Hasnaoui-Saadani
Universite Paris, Bobigny, France
Am J Physiol Regul Integr Comp Physiol 296:R801-11. 2009..levels of hypoxia-inducible factor 1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), erythropoietin receptors (EpoR), phospho-STAT-5/STAT-5 ratio, and neuronal neuronal nitric oxide synthase (nNOS) along with a ..
- Erythropoietin and renoprotectionFerdinand H Bahlmann
Department of Internal Medicine IV, Saarland University Medical Centre, Homburg Saar, Germany
Curr Opin Nephrol Hypertens 18:15-20. 2009..Finally, we will review the current literature on clinical studies with rHuEPO or analogous substances and progression of chronic kidney disease, and propose possible clinical renoprotective strategies...
- A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor geneMaha Al-Sheikh
INSERM, U841, Creteil, France
Haematologica 93:1072-5. 2008..6146A>G (p.Asn487Ser)] and another, a silent one (g.5799G>A). All were heterozygotes. In addition, 2 patients were positive for JAK2 (Val617Phe), and 2 reported elsewhere, were mutated in the PHD2 gene [c.606delG (p.Met202IlefsX71)...
- Activation of erythropoietin receptors by Friend viral gp55 and by erythropoietin and down-modulation by the murine Fv-2r resistance geneM E Hoatlin
Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098
Proc Natl Acad Sci U S A 87:9985-9. 1990..leukemogenic membrane glycoprotein (gp55) encoded by Friend spleen focus-forming virus appears to bind to erythropoietin receptors (EpoR) sto stimulate erythroblastosis [Li, J.-P., D'Andrea, A.D., Lodish, H.F. & Baltimore, D...
- Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in Ba/F3 cells via the IL-3 receptor alpha subunitJ Krosl
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
J Biol Chem 271:27432-7. 1996Introduction of erythropoietin receptors (EpoRs) into the interleukin-3 (IL-3)-dependent murine hemopoietic cell line, Ba/F3, enables these cells to not only proliferate, after an initial lag in G1, but also to increase beta-globin mRNA ..
- Erythropoietin receptors on tumor cells: what do they mean?Joachim Fandrey
Institut fur Physiologie, Universitat Duisburg Essen, Hufelandstr 55, D 45147 Essen, Germany
Oncologist 13:16-20. 2008Given the apparent presence of erythropoietin receptors (EPORs) in cancer tissues, questions have been raised about the possible influence of erythropoiesis-stimulating agents (ESAs) on tumor growth and proliferation...
- Cell surface site for mitogenic interaction of erythropoietin receptors with the membrane glycoprotein encoded by Friend erythroleukemia virusF E Ferro
Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health Sciences University, Portland 97201 3098
J Biol Chem 268:5741-7. 1993..Recent evidence suggested that gp55 binds to erythropoietin receptors (EpoR) in the RER, and it was proposed that this intracellular interaction causes mitogenesis (Li, J.-P...
- Human erythropoietin receptor: cloning, expression, and biologic characterizationS S Jones
Genetics Institute, Cambridge, MA 02140
Blood 76:31-5. 1990..The murine interleukin-3-dependent pre-B-lymphocyte cell line, Ba/F3, was made EPO-dependent by transfection of the human cDNA into the cells and selecting for growth in EPO-containing media...
- An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: a cytokine receptor superfamily oncogeneG D Longmore
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
Cell 67:1089-102. 1991..The activated erythropoietin receptor does not transform cultured fibroblasts, suggesting why oncogenic mutations in other members of this receptor superfamily have not been detected...
- Isolation of a cDNA encoding a potential soluble receptor for human erythropoietinK Todokoro
Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
Gene 106:283-4. 1991..Analysis of human erythropoietin receptor-encoding cDNAs revealed the possible existence of a soluble receptor lacking the transmembrane and cytoplasmic domains...
- Erythropoietin stimulates proliferation of human renal carcinoma cellsC Westenfelder
Division of Nephrology, Veterans Administration and University of Utah Medical Centers, Salt Lake City 84148, USA
Kidney Int 58:647-57. 2000..The present study examines whether EPO could elicit such a proliferative and thereby potentially detrimental response in cells of human renal-cell carcinoma (RCC)...
- The intron 5-inserted form of rat erythropoietin receptor is expressed as a membrane-bound formR Yamaji
Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
Biochim Biophys Acta 1403:169-78. 1998....
- Inactivation of erythropoietin leads to defects in cardiac morphogenesisH Wu
Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA 90095 1735, USA
Development 126:3597-605. 1999....
- Erythropoietin receptor expression in human melanoma cellsE Selzer
Department of Radiotherapy and Radiobiology, University Hospital, Vienna, Austria
Melanoma Res 10:421-6. 2000..This observation might be useful in the early diagnosis of melanoma...
- Preclinical studies of erythropoietin receptor expression in tumour cells: impact on clinical use of erythropoietic proteins to correct cancer-related anaemiaAnders Osterborg
Department of Oncology, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
Eur J Cancer 43:510-9. 2007..Together with diverging results in the literature, these methodological limitations indicate that findings from preclinical studies must not be over-translated in terms of their clinical relevance to patients with cancer...
- The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19pJ C Winkelmann
Department of Medicine, University of Minnesota, Minneapolis
Blood 76:24-30. 1990..The human Epo receptor gene is localized to human chromosome 19p by in situ hybridization. This chromosome assignment is confirmed by hybridization to a panel of sorted human chromosomes...
- Biology of erythropoietinC Lacombe
Institut National de la Sante et de la Recherche Medicale, Unité 363, ICGM, Universite Rene Descartes, Paris, France
Haematologica 83:724-32. 1998..Furthermore, target disruption of both Epo and Epo receptor showed that Epo was not involved in the commitment of the erythroid lineage and seemed to act mainly as a survival factor...
- Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemiaR Kralovics
University of Alabama at Birmingham, Division of Hematology Oncology, Birmingham, Alabama 35294 0006, USA
J Clin Invest 102:124-9. 1998..Failure of this child to develop polycythemia suggests the existence of as yet unidentified environmental or genetic factors that may suppress disease development...
- Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and functionStephane Pelletier
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Mol Cell Biol 26:8527-38. 2006..Collectively, the results suggest that Jak2 is the sole direct signaling molecule downstream of EpoR required for biological activity...
- Impaired erythropoiesis after haemorrhagic shock in mice is associated with erythroid progenitor apoptosis in vivoY Robinson
Centre for Trauma and Reconstructive Surgery, Charite Campus Benjamin Franklin, Berlin, Germany
Acta Anaesthesiol Scand 52:605-13. 2008..Therefore, the underlying mechanisms were investigated in bone marrow (BM) and peripheral blood in a murine resuscitated haemorrhagic shock (HS) model...
- Erythropoiesis-stimulating agents: favorable safety profile when used as indicatedMohammad R Nowrousian
Department of Internal Medicine Cancer Research, West German Cancer Center, University Hospital Essen, Germany
Strahlenther Onkol 184:121-36. 2008..Several studies with erythropoiesis-stimulating agents (ESAs) have raised a number of safety issues. Therefore, a discussion of available data in light of the current EORTC guidelines 2006 on the use of ESAs in anemic patients is warranted...
- Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase CgammaAdrienne Halupa
Division of Stem Cell and Developmetal Biology, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada M5G 2M9
Exp Cell Res 309:1-11. 2005..Hence, we have identified a novel adapter function for PLCgamma1 in EPO signaling in which recruitment of PLCgamma1 to EPO-R may lead to activation of the ERK pathway...
- Turning cells red: signal transduction mediated by erythropoietinTerri D Richmond
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada
Trends Cell Biol 15:146-55. 2005..In this review, we summarize EPO-mediated signaling pathways and examine their significance in vivo...
- Erythropoietin: new approaches to improved molecular designs and therapeutic alternativesN Debeljak
Center for Functional Genomics and Bio Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Zaloska 4, SI 1000 Ljubljana, Slovenia
Curr Pharm Des 14:1302-10. 2008..The demonstration that Epo can trigger signaling in some cancer cells with, potentially, adverse effects on patient health has raised warning signs in the medical community and has gained the attention of regulatory authorities...
- Pleiotropic functions of erythropoietinRyuzo Sasaki
Department of Life Style Studies, School of Human Cultures, The University of Shiga, Shiga
Intern Med 42:142-9. 2003..The uterine EPO is likely involved in the estrogen-dependent angiogenesis of the endometrial layer. The possible functions of EPO in other tissues and tissue-characteristic regulation of EPO production are also discussed in this review...
- Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathwaysWei Tong
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Blood 105:4604-12. 2005..Hence, Lnk, through its SH2 domain, negatively modulates EpoR signaling by attenuating JAK2 activation, and regulates Epo-mediated erythropoiesis...
- Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2Ulkan Kilic
Department of Neurology, University Hospital Zurich, Switzerland
FASEB J 19:249-51. 2005....
- Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survivalWaheed Sangrar
Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
Exp Hematol 32:935-45. 2004..In this study we wished to determine if Fps/Fes also plays a role in the regulation of erythropoiesis...
- The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutationTaghi Manshouri
Department of Leukemia, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Sci 99:1265-73. 2008..Flow cytometric analysis of expanded PV progenitor cells treated with CP-690,550 suggests a possible transition towards a pattern of erythroid differentiation resembling expanded cells from normal healthy controls...
- Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalphaJorge P Pinto
Iron Genes and Immune System, Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal
Blood 111:5727-33. 2008....
- Expression of EPO receptor in pancreatic cells and its effect on cell apoptosisHongxia Shuai
Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
J Huazhong Univ Sci Technolog Med Sci 28:49-51. 2008..From these findings, it was concluded that EPOR was expressed in NIT-1 cells and EPO could protect NIT-1 cells from apoptosis induced by cytokines...
- Functional conservation of erythropoietin signaling in zebrafishNoelle Paffett-Lugassy
Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Blood 110:2718-26. 2007..Together, the characterization of zebrafish epo and epor demonstrates the conservation of an ancient program that ensures proper red blood cell numbers during normal homeostasis and under hypoxic conditions...
- Erythropoietin receptor signal transduction requires protein geranylgeranylationSumaya N Hamadmad
Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
J Pharmacol Exp Ther 316:403-9. 2006..These results indicate that protein geranylgeranylation and not farnesylation is important for proper Epo signal transduction...
- Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathwayWei Zhao
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Blood 107:907-15. 2006..These data demonstrate that EpoR signaling phosphorylates GATA-1 and modulates its activity via the PI3-kinase/AKT signaling pathway...
- Erythropoietin biology in cancerMatthew E Hardee
Department of Pathology, Duke University Medical Center, Durham, NC 22710, USA
Clin Cancer Res 12:332-9. 2006..This review describes Epo and EpoR biology, focusing on the pleiotropic effects of Epo on nonhematopoietic tissues as well as the expression and function of EpoR in cancer cells...
- AKT Signaling and Oxidative Stress Regulation of ErythropoiesisSaghi Ghaffari; Fiscal Year: 2009..These studies will have a critical impact on our understanding of mechanisms of different types of anemias and how to increase red blood cell production. ..
- AKT Signaling and Oxidative Stress Regulation of ErythropoiesisSaghi Ghaffari; Fiscal Year: 2010..These studies will have a critical impact on our understanding of mechanisms of different types of anemias and how to increase red blood cell production. ..
- IN VIVO SIGNALING OF THE ERYTHROPOIETIN RECEPTORSaghi Ghaffari; Fiscal Year: 2002....
- Erythropoietin receptor /Janus Kinase 2 complexLily Huang; Fiscal Year: 2006..Through this research proposal, the applicant will receive training in biophysical and structural biology and will gain the necessary skills and knowledge to become an independent investigator. ..
- ERYTHROPOIETIN RECEPTOR REGULATION OF ERYTHROPOIESISMURAT ARCASOY; Fiscal Year: 2002....
- Molecular Biology of PolycythemiaJosef Prchal; Fiscal Year: 2007..Aim 3 Determine the genetic and molecular basis for congenital polycythemias characterized by elevated Epo concentrations and mutations of other than the VHL gene. ..
- Nonhematopoietic Developmental Functions of EPOSandra Juul; Fiscal Year: 2004b>Erythropoietin receptors are present on intestinal cells of the human fetus and neonate...
- Characterization of a Novel Erythropoietin Signaling PathwayAdam N Goldfarb; Fiscal Year: 2010..One specific topic listed in this announcement is "Non-erythroid Expression and Function of Erythropoietin Receptors." A significant component of this project will be devoted to analysis of myocardial PKD activation by Epo ..
- CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUSDaniel DiMaio; Fiscal Year: 2010..In addition, on the basis of these studies, we will continue to develop a novel protein engineering method to control biological processes, including infection by human immunodeficiency virus, an important co-factor in many cancers. ..
- Role of NIX in Erythroid MaturationPAUL NEY; Fiscal Year: 2007..We propose to explore that possibility in experiments with Nix mice and other BCL2-related mouse strains. ..
- Fetal Stem Cell Gene TherapyMARCUS MUENCH; Fiscal Year: 2003..A positive outcome from the proposed studies would aid in developing treatments for hemoglobinopathies based on generating hematopoietic allochimerism. ..
- Erythropoietin receptor signaling in erythropoiesisLily Huang; Fiscal Year: 2009..Information gained from these studies will lead to a more comprehensive understanding of how EpoR signaling regulates erythropoiesis and how oncogenic EpoR and JAK2 activation induces leukemia. ..
- Role of Erythropoietin receptor signaling in heartMURAT ARCASOY; Fiscal Year: 2004..abstract_text> ..
- Erythropoietin Blockade for the Treatment of CancerC Anthony Blau; Fiscal Year: 2010..First, we will develop a diagnostic assay to predict which patients are most susceptible to erythropoietin induced tumor growth. Second, we propose a new strategy for treating tumors that is based on erythropoietin blockade. ..
- SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETINBarbara Miller; Fiscal Year: 2006..TRPC2 knockout mice will be used to examine the rote of TRPC2 in viability, proliferation, apoptosis induction and cell cycle progression of primary erythroid cells. ..
- Erythropoietin Blockade for the Treatment of CancerC Anthony Blau; Fiscal Year: 2009..First, we will develop a diagnostic assay to predict which patients are most susceptible to erythropoietin induced tumor growth. Second, we propose a new strategy for treating tumors that is based on erythropoietin blockade. ..
- ROLE OF FV2 IN ERYTHROPOIESISPAUL NEY; Fiscal Year: 2004..These studies should improve our understanding of normal hematopoiesis and leukemic transformation. ..
- XRAY STUDIES OF EPO AND IL2 RECEPTOR COMPLEXESIan Wilson; Fiscal Year: 2001..The crystallographic study of IL-2 mutants and various forms of the receptor complex should give insights into the structure and function of this key receptor in T cell growth and proliferation. ..