erythropoietin receptors

Summary

Summary: Cell surface proteins that bind erythropoietin with high affinity and trigger intracellular changes influencing the behavior of cells.

Top Publications

  1. ncbi Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades
    M Digicaylioglu
    Center for Neuroscience and Aging Research, The Burnham Institute, La Jolla, CA 92037, USA
    Nature 412:641-7. 2001
  2. ncbi JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    B A Witthuhn
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 74:227-36. 1993
  3. pmc Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    M L Brines
    The Kenneth S Warren Laboratories, 765 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 97:10526-31. 2000
  4. ncbi Expression and function of erythropoietin receptors in tumors: implications for the use of erythropoiesis-stimulating agents in cancer patients
    Angus M Sinclair
    Amgen Inc, Thousand Oaks, California, USA
    Cancer 110:477-88. 2007
  5. ncbi Human, rat, and mouse kidney cells express functional erythropoietin receptors
    C Westenfelder
    Division of Nephrology, VA Medical Center, Salt Lake City, Utah 84148, USA
    Kidney Int 55:808-20. 1999
  6. ncbi Erythropoietin and erythropoietin receptor expression in human cancer
    G Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:3561-5. 2001
  7. ncbi Efficiency of signalling through cytokine receptors depends critically on receptor orientation
    R S Syed
    Amgen Inc, Thousand Oaks, California 91320 1789, USA
    Nature 395:511-6. 1998
  8. ncbi Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis
    C S Lin
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genes Dev 10:154-64. 1996
  9. ncbi The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
    L J Huang
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 8:1327-38. 2001
  10. pmc Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia
    Rita Sulahian
    Departments of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 75390 9039, USA
    Blood 113:5287-97. 2009

Research Grants

Detail Information

Publications209 found, 100 shown here

  1. ncbi Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades
    M Digicaylioglu
    Center for Neuroscience and Aging Research, The Burnham Institute, La Jolla, CA 92037, USA
    Nature 412:641-7. 2001
    ..Thus neuronal EPORs activate a neuroprotective pathway that is distinct from previously well characterized Jak and NF-kappaB functions. Moreover, this EPO effect may underlie neuroprotection mediated by hypoxic-ischaemic preconditioning...
  2. ncbi JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    B A Witthuhn
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 74:227-36. 1993
    ..The results support the hypothesis that JAK2 is the kinase that couples EPO binding to tyrosine phosphorylation and mitogenesis...
  3. pmc Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    M L Brines
    The Kenneth S Warren Laboratories, 765 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 97:10526-31. 2000
    ..Given r-Hu-EPO's excellent safety profile, clinical trials evaluating systemically administered r-Hu-EPO as a general neuroprotective treatment are warranted...
  4. ncbi Expression and function of erythropoietin receptors in tumors: implications for the use of erythropoiesis-stimulating agents in cancer patients
    Angus M Sinclair
    Amgen Inc, Thousand Oaks, California, USA
    Cancer 110:477-88. 2007
    ..For this report, the authors reviewed the biology of EpoR in erythropoiesis and compared and contrasted the reported findings on the role of ESAs and EpoR in tumors...
  5. ncbi Human, rat, and mouse kidney cells express functional erythropoietin receptors
    C Westenfelder
    Division of Nephrology, VA Medical Center, Salt Lake City, Utah 84148, USA
    Kidney Int 55:808-20. 1999
    ..We examined whether renal cells that are exposed to EPO express EPO receptors (EPO-R) through which analogous cytokine responses might be elicited...
  6. ncbi Erythropoietin and erythropoietin receptor expression in human cancer
    G Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:3561-5. 2001
    ..Hypoxic tumor regions display the highest levels of EPO and EPOR expression. Enhanced EPO signaling may contribute to the promotion of human cancer by tissue hypoxia...
  7. ncbi Efficiency of signalling through cytokine receptors depends critically on receptor orientation
    R S Syed
    Amgen Inc, Thousand Oaks, California 91320 1789, USA
    Nature 395:511-6. 1998
    ..It activates cells by binding and orientating two cell-surface erythropoietin receptors (EPORs) which trigger an intracellular phosphorylation cascade...
  8. ncbi Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis
    C S Lin
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Genes Dev 10:154-64. 1996
    ....
  9. ncbi The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
    L J Huang
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 8:1327-38. 2001
    ..Thus, in addition to its kinase activity required for cytokine receptor signaling, JAK is also an essential subunit required for surface expression of cytokine receptors...
  10. pmc Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia
    Rita Sulahian
    Departments of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 75390 9039, USA
    Blood 113:5287-97. 2009
    ....
  11. ncbi Erythropoietin stimulates proliferation of human renal carcinoma cells
    C Westenfelder
    Division of Nephrology, Veterans Administration and University of Utah Medical Centers, Salt Lake City 84148, USA
    Kidney Int 58:647-57. 2000
    ..The present study examines whether EPO could elicit such a proliferative and thereby potentially detrimental response in cells of human renal-cell carcinoma (RCC)...
  12. ncbi The erythropoietin receptor and its expression in tumor cells and other tissues
    Francis Farrell
    Growth Factors Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, 1000 Route 202, Raritan, NJ 08869, USA
    Oncologist 9:18-30. 2004
    ..Clearly, further study of EPO and the EPO receptor in nonhematopoietic tissue is warranted to determine the potential therapeutic usefulness of rHuEPO as well as to determine the signaling pathway responsible for its effect in vivo...
  13. ncbi Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway
    H Chin
    First Department of Internal Medicine and School of Allied Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Blood 91:3734-45. 1998
    ..In addition, Lyn was demonstrated to phosphorylate the EpoR and Stat5 on tyrosines in vitro. These results suggest that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpoR...
  14. ncbi The role of erythropoietin in regulating angiogenesis
    Nathalie Kertesz
    Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA, 90095 1735, USA
    Dev Biol 276:101-10. 2004
    ..Moreover, Ang-1 expression is regulated by EPO/EPOR under normoxic conditions. Taken together, our results suggest important roles of EPO and EPOR in angiogenesis...
  15. ncbi Recombinant human erythropoietin alpha targets intratumoral blood vessels, improving chemotherapy in human xenograft models
    Jozsef Tovari
    Department of Tumor Progression and Central Laboratory, National Institute of Oncology, Budapest, Hungary
    Cancer Res 65:7186-93. 2005
    ....
  16. ncbi Expression of erythropoietin receptor splice variants in human cancer
    Murat O Arcasoy
    Department of Medicine, Division of Hematology Medical Oncology, Duke University School of Medicine, DUMC Box 3912, Durham, NC 27710, USA
    Biochem Biophys Res Commun 307:999-1007. 2003
    ..These findings indicate the expression of multiple EPOR isoforms in human cancer cells that may modulate the cellular effects of recombinant human EPO or EPO-EPOR antagonists...
  17. ncbi Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts
    M Socolovsky
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Blood 98:3261-73. 2001
    ..Decreased expression of bcl-x(L) and increased apoptosis in Stat5a(-/-)5b(-/-) early erythroblasts correlate with the degree of anemia. Hence, Stat5 controls a rate-determining step regulating early erythroblast survival...
  18. ncbi Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    H Wu
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Cell 83:59-67. 1995
    ..EPO and the EPOR are crucial in vivo for the proliferation and survival of CFU-E progenitors and their irreversible terminal differentiation...
  19. ncbi Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs
    Yoshiko Yasuda
    Department of Anatomy, Kinki University School of Medicine, Osaka Sayama, Japan
    Carcinogenesis 23:1797-805. 2002
    ..Thus, deprivation of erythropoietin signalling may be a useful therapy for erythropoietin-producing malignant tumours...
  20. ncbi Erythropoietin receptor expression in non-small cell lung carcinoma: a question of antibody specificity
    W Mark Brown
    Department of Pathology, Institute of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BA, United Kingdom
    Stem Cells 25:718-22. 2007
    ....
  21. ncbi Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality
    Norio Suzuki
    Center for Tsukuba Advanced Research Alliance, Institutes of Basic Medical Sciences and Clinical Medicine, University of Tsukuba, Tokyo, Japan
    Blood 100:2279-88. 2002
    ..We thus conclude that nonhematopoietic expression of EpoR is dispensable to normal mouse development and that the expression level of EpoR regulates erythropoiesis by controlling the sensitivity of erythroid progenitors to Epo...
  22. ncbi Erythropoietin receptor signalling is required for normal brain development
    Xiaobing Yu
    Laboratory of Chemical Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Development 129:505-16. 2002
    ..5 in the developing brain, and that induction of erythropoietin and its receptor by hypoxia may contribute to selective cell survival in the brain...
  23. doi Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout the life span
    Pascal E Sanchez
    Universite de Lyon, Lyon, France
    J Comp Neurol 514:403-14. 2009
    ..Given that Epo protects extended populations of neurons after injury, a yet-to-be-identified receptor heterocomplex including Epo-R may exist in the large population of brain neurons that does not express betac...
  24. ncbi Signal transduction in the erythropoietin receptor system
    D M Wojchowski
    Program in Cell and Developmental Biology, Pennsylvania State University, University Park, Pennsylvania, 16802, USA
    Exp Cell Res 253:143-56. 1999
    ....
  25. ncbi Anti-Epo receptor antibodies do not predict Epo receptor expression
    Steve Elliott
    Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA 91320, USA
    Blood 107:1892-5. 2006
    ..We concluded that these antibodies have limited utility for detecting EpoR. Thus, reports of EpoR expression in tumor cells using these antibodies should be viewed with caution...
  26. pmc Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor
    Michael Brines
    Kenneth S Warren Institute, Ossining, NY 10563, USA
    Proc Natl Acad Sci U S A 101:14907-12. 2004
    ..These data support the concept that EpoR and betacR comprise a tissue-protective heteroreceptor...
  27. ncbi Human erythropoietin receptor: cloning, expression, and biologic characterization
    S S Jones
    Genetics Institute, Cambridge, MA 02140
    Blood 76:31-5. 1990
    ..The murine interleukin-3-dependent pre-B-lymphocyte cell line, Ba/F3, was made EPO-dependent by transfection of the human cDNA into the cells and selecting for growth in EPO-containing media...
  28. ncbi Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis
    M von Lindern
    Institute of Hematology, Erasmus Medical Centre Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Oncogene 20:3651-64. 2001
    ..However, while v-ErbB transformed cells and normal progenitors depended on PI3K signaling for renewal, c-ErbB also induces progenitor expansion by PI3K-independent mechanisms...
  29. doi Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle
    Carsten Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 3, 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 104:1154-60. 2008
    ..However, in contrast to our hypothesis, prolonged Epo administration had no apparent effect on capillarization or muscle fiber hypertrophy...
  30. ncbi Erythropoietin receptors: their role beyond erythropoiesis
    Jerome Rossert
    Nephrol Dial Transplant 20:1025-8. 2005
  31. ncbi Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy
    Daisuke Watanabe
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    N Engl J Med 353:782-92. 2005
    ..Hence, it is postulated that there are other potent ischemia-induced angiogenic factors. Erythropoietin possesses angiogenic activity, but its potential role in ocular angiogenesis is not established...
  32. doi Erythropoietin improves functional and histological recovery of traumatized skeletal muscle tissue
    Robert Rotter
    Department of Trauma and Reconstructive Surgery, University of Rostock, 18055 Rostock, Germany
    J Orthop Res 26:1618-26. 2008
    ..Thus, EPO, a compound established as clinically safe, may represent a promising therapeutic option to optimize the posttraumatic course of muscle tissue healing...
  33. ncbi beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation
    Laure Meyer
    Institut Cochin, Departement d Hematologie, Paris, France
    Blood 109:5215-22. 2007
    ....
  34. ncbi Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin
    Joan C Egrie
    Amgen Inc, Thousand Oaks, Calif 91320, USA
    Exp Hematol 31:290-9. 2003
    ..Darbepoetin alfa, a hyperglycosylated recombinant human EPO (rHuEPO) analogue with two extra carbohydrate chains, was designed and developed to test this hypothesis...
  35. ncbi Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia
    Murat O Arcasoy
    Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Clin Cancer Res 11:20-7. 2005
    ....
  36. pmc Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells
    Emilia Stellacci
    Department of Infectious, Parasitic and Immunomediated Diseases, University of Chieti Pescara, Chieti, Italy
    Exp Hematol 37:559-72. 2009
    ....
  37. ncbi Erythropoietin biology in cancer
    Matthew E Hardee
    Department of Pathology, Duke University Medical Center, Durham, NC 22710, USA
    Clin Cancer Res 12:332-9. 2006
    ..This review describes Epo and EpoR biology, focusing on the pleiotropic effects of Epo on nonhematopoietic tissues as well as the expression and function of EpoR in cancer cells...
  38. ncbi The impact of tumor expression of erythropoietin receptors and erythropoietin on clinical outcome of esophageal cancer patients treated with chemoradiation
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 71:152-9. 2008
    To investigate the impact of tumor erythropoietin receptors (Epo-R) and erythropoietin (Epo) expression in 64 patients with Stage III esophageal cancer receiving or not receiving erythropoietin during chemoradiation.
  39. ncbi Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain
    A L Siren
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Acta Neuropathol 101:271-6. 2001
    ....
  40. ncbi The presence of erythropoietin receptors in the human peripheral nervous system
    K Hassan
    Nephrology and Hypertension Department, Western Galilee Hospital, Nahariya, Israel
    Clin Nephrol 61:127-9. 2004
    ..By examining nerve segments from radicular and autonomic nerves using immunohistochemical methods, we demonstrated the presence of EPO receptors on myelin sheath of radicular nerves in the human peripheral nervous system...
  41. ncbi Inactivation of erythropoietin leads to defects in cardiac morphogenesis
    H Wu
    Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, CA 90095 1735, USA
    Development 126:3597-605. 1999
    ....
  42. pmc Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation
    J E Damen
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada
    EMBO J 14:5557-68. 1995
    While previous studies with truncated erythropoietin receptors (EpRs) have suggested that the tyrosine phosphorylation of the EpR does not play a role in Ep-induced proliferation, we have found, using a more subtle, full length EpR mutant,..
  43. ncbi Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival
    Sandeep Batra
    Division of Hematology Oncology, Childrens Hospital Los Angeles, California, USA
    Lab Invest 83:1477-87. 2003
    ..Therefore, a careful evaluation of the impact of erythropoietin is warranted in vivo, in xenograft models of pediatric tumors, followed by evaluation in pediatric patients with cancer...
  44. ncbi The cellular biology of erythropoietin receptors
    Terry Lappin
    Queen s University Belfast, Belfast City Hospital, Belfast, Northern Ireland
    Oncologist 8:15-8. 2003
    ..Organs such as the brain, ovary, oviduct, uterus, and testis have erythropoietin receptors. Because erythropoietin receptors exist in the paracrine and autocrine systems, as well as the hormonal ..
  45. ncbi Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model
    Karsten Ruscher
    Department of Experimental Neurology, Charite Hospital, Humboldt University, D 10098 Berlin, Germany
    J Neurosci 22:10291-301. 2002
    ..PI3K deactivates BAD via Akt-mediated phosphorylation and thus may inhibit hypoxia-induced apoptosis in neurons. Our results establish EPO as an important paracrine neuroprotective mediator of ischemic preconditioning...
  46. ncbi Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemia
    T Motohashi
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba and CREST JST, Tsukuba, Ibaraki, Japan
    Eur J Haematol 67:88-93. 2001
    ....
  47. ncbi Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma
    Youn Soo Lee
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Cancer Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 11:1059-64. 2005
    ..Such arrest may lead to autocrine stimulation, cell proliferation, and renal tumor development, similar to tumorigenesis of VHL disease-associated hemangioblastomas...
  48. ncbi Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
    U Klingmuller
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 80:729-38. 1995
    ..Our results suggest that activation of SH-PTP1 by binding to the EPO-R plays a major role in terminating proliferative signals...
  49. doi Erythropoietin and renoprotection
    Ferdinand H Bahlmann
    Department of Internal Medicine IV, Saarland University Medical Centre, Homburg Saar, Germany
    Curr Opin Nephrol Hypertens 18:15-20. 2009
    ..Finally, we will review the current literature on clinical studies with rHuEPO or analogous substances and progression of chronic kidney disease, and propose possible clinical renoprotective strategies...
  50. pmc Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis
    Madhu P Menon
    Stem and Progenitor Cell Biology Program, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Clin Invest 116:683-94. 2006
    ..Stress erythropoiesis, therefore, requires stage-specific EpoR-PY343-Stat5 signals, some of which selectively bolster SCF and oncostatin-M action...
  51. pmc Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
    Xiaohui Lu
    Whitehead Institute for Biomedical Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 102:18962-7. 2005
    ..Our results reveal the molecular basis for the prevalence of JAK2V617F in diseases of myeloid lineage cells that express these Type I cytokine receptors but not in lymphoid lineage cells that do not...
  52. pmc Role of erythropoietin in the brain
    Constance Tom Noguchi
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1822, USA
    Crit Rev Oncol Hematol 64:159-71. 2007
    ..The therapeutic potential of EPO for brain ischemia/trauma and neurodegenerative diseases has shown promise in early clinical trial and awaits further validation...
  53. ncbi Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation
    Didier Bouscary
    Departement d Hematologie, Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique, UMR 8104, Universite Rene Descartes, Paris, France
    Blood 101:3436-43. 2003
    ....
  54. ncbi Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor
    Agnete Kirkeby
    Department of Molecular Neurobiology, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    J Neurosci Methods 164:50-8. 2007
    ..Here, only the MAB307 antibody showed a partial effect at concentrations of 5-50 microg/ml...
  55. ncbi Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells
    S Masuda
    Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
    J Biol Chem 268:11208-16. 1993
    ..The addition of Epo to the culture media of PC12 cells elevated the intracellular concentrations of monoamines...
  56. ncbi Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture
    A Nagai
    Department of Medicine, University of British Columbia, Vancouver, Canada
    J Neuropathol Exp Neurol 60:386-92. 2001
    ..These results suggest that proinflammatory cytokines regulate expression of EPO and EPOR in human neurons, astrocytes, and microglia and further facilitate interactions among different cell types in the human CNS...
  57. ncbi Derivatives of erythropoietin that are tissue protective but not erythropoietic
    Marcel Leist
    H Lundbeck A S, 2500 Valby, Denmark
    Science 305:239-42. 2004
    ....
  58. pmc A constitutively activated erythropoietin receptor stimulates proliferation and contributes to transformation of multipotent, committed nonerythroid and erythroid progenitor cells
    G D Longmore
    Department of Medicine, Washington University, St Louis, Missouri 63110
    Mol Cell Biol 14:2266-77. 1994
    ..The sites of proviral integration in clonal cell lines are distinct from those in SFFV-derived lines...
  59. ncbi Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors
    Virginie Moucadel
    Ludwig Institute for Cancer Research, Brussels B 1200, Belgium
    J Biol Chem 280:13364-73. 2005
    ....
  60. pmc Functional erythropoietin autocrine loop in melanoma
    Suresh M Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Pathol 166:823-30. 2005
    ..The results suggest that the autocrine and paracrine functions of Epo might play a role in malignant transformation of melanocytes and in the survival of melanoma cells in hypoxia and other adverse conditions...
  61. pmc Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia
    Monica Fantacci
    Department of Medicine, University of Milan, San Paolo Hospital, Milan 20142, Italy
    Proc Natl Acad Sci U S A 103:17531-6. 2006
    ..These observations therefore demonstrate that CEpo administration reduces the metabolic stress caused by severe CH, resulting in improved cellular survival independent of erythrocyte production...
  62. pmc Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 162:1789-806. 2003
    ..Hypoxia-inducible Epo signaling may play a significant role in the aggressive behavior and treatment resistance of hypoxic cervical cancers...
  63. pmc A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    A Yoshimura
    Cancer Research Institute, Faculty of Medicine, Kagoshima University, Japan
    EMBO J 14:2816-26. 1995
    ..Thus CIS appears to be a unique regulatory molecule for cytokine signal transduction...
  64. ncbi Erythropoietin stimulates growth and STAT5 phosphorylation in human prostate epithelial and prostate cancer cells
    Laurie Feldman
    Laboratory for Cell and Molecular Biology, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Prostate 66:135-45. 2006
    ..EpoR have been identified on a variety of non-hematopoietic cells, both normal and malignant, however, little is known about the function of EpoR on malignant cells...
  65. ncbi Prognostic significance of erythropoietin expression in human endometrial carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer 100:2376-86. 2004
    ..The authors recently demonstrated hypoxia-stimulated expression of Epo and Epo receptor (EpoR) in human breast and cervical carcinomas, suggesting a role for autocrine Epo signaling in the hypoxic adaptations of carcinomas...
  66. ncbi Familial and congenital polycythemias: a diagnostic approach
    Tom Van Maerken
    Department of Pediatric Hematology Oncology, University Hospital Ghent, Belgium
    J Pediatr Hematol Oncol 26:407-16. 2004
    ..In this article the authors describe a child with primary FCP, review the different FCPs, and propose an adapted work-up scheme...
  67. ncbi Integrative signaling by minimal erythropoietin receptor forms and c-Kit
    T J Pircher
    Department of Veterinary Science, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 276:8995-9002. 2001
    ..Thus, integration circuits exist in only select downstream pathways within Epo and stem call factor receptor signaling...
  68. ncbi Detection and quantification of the soluble form of the human erythropoietin receptor (sEpoR) in the growth medium of tumor cell lines and in the plasma of blood samples
    G Westphal
    Division of Radiobiology and Radiooncology, German Cancer Research Center DKFZ, Heidelberg
    Clin Exp Med 2:45-52. 2002
    ..In conclusion, an ELISA to quantify the sEpoR was established and the expression of sEpoR in human tumor cell lines was demonstrated for the first time...
  69. pmc Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury
    Anna K Junk
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:10659-64. 2002
    ..These results further establish EPO as a neuroprotective agent in acute neuronal ischemic injury...
  70. pmc New avenues of exploration for erythropoietin
    Kenneth Maiese
    Division of Cellular and Molecular Cerebral Ischemia, Department of Neurology, Wayne State University School of Medicine, Detroit, Mich 48201, USA
    JAMA 293:90-5. 2005
    ....
  71. ncbi Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor-positive breast carcinoma models
    Kenneth R LaMontagne
    Drug Discovery, Growth Factors, Johnson and Johnson Pharmaceutical Research and Development, Room B354, OMP Building, 1000 Route 202, PO Box 300, Raritan, NJ 08869, USA
    Mol Cancer Ther 5:347-55. 2006
    ..These results show that recombinant epoetins do not evoke a physiologic response on EPOR-bearing tumor cells as assessed by numerous variables, including growth, migration, and cytotoxic challenge in preclinical in vivo tumor models...
  72. ncbi Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism
    Changmin Chen
    Laboratory for Cell and Molecular Biology, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Blood 104:73-80. 2004
    ..These results indicate the presence of a Ras-independent mechanism for Raf-1 and MEK activation in these cells...
  73. ncbi Human, nonhuman primate, and rat pancreatic islets express erythropoietin receptors
    Elizabeth S Fenjves
    Diabetes Research Institute, University of Miami, School of Medicine, Miami, FL 33136, USA
    Transplantation 75:1356-60. 2003
    ..The authors examined pancreatic islets for the presence of EPO-R to determine whether these cells are protected by EPO from cytokine-induced apoptosis...
  74. ncbi Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinoma
    Stuart C Winter
    Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford
    Clin Cancer Res 11:7614-20. 2005
    ..This study examines the protein and mRNA expression of erythropoietin and erythropoietin receptor in HNSCC and their relation to hypoxia, hemoglobin (Hb), and clinical outcome...
  75. ncbi Erythropoietin regulates tumour growth of human malignancies
    Yoshiko Yasuda
    Department of Anatomy, Division 1, Kinki University School of Medicine, Osaka Sayama, Japan
    Carcinogenesis 24:1021-9. 2003
    ..These findings suggest that Epo is indispensable for the growth and viability of malignant tumour and also that the deprivation of Epo signalling may be a promising therapy for human malignancy...
  76. ncbi Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Cancer 95:969-81. 2002
    ....
  77. ncbi Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation
    Makoto Sugawa
    Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Company Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Neurosci Res 44:391-403. 2002
    ..These comprehensive effects of Epo might also affect the ability of oligodendrocyte lineage cells to promote myelin repair in the normal and damaged adult central nervous system...
  78. ncbi Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit
    Ke Li
    Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 278:40702-9. 2003
    ..Instead, co-signaling appears to depend upon the downstream integration of Kit signals with the targets of an EpoR/Jak2/Y343/Stat 5 response axis...
  79. ncbi Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor
    Bai Lin Tan
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:11686-95. 2003
    ..These data demonstrate an essential role for Src pathway in regulating growth, proliferation, and cooperation with Epo-R downstream from Kit...
  80. ncbi Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeability
    Ofelia María Martínez-Estrada
    Departament de Biologia Cel lular, Facultat Biologia, Universitat de Barcelona, E 08028 Barcelona, Spain
    Eur J Neurosci 18:2538-44. 2003
    ..Our results suggest a new mechanism for Epo-induced neuroprotection, in which circulating Epo controls and maintains the BBB through an Epo receptor signalling pathway and the re-establishment of cell junctions...
  81. ncbi Role of c-Kit and erythropoietin receptor in erythropoiesis
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Cancer Research Building, Indianapolis, IN 46202, USA
    Crit Rev Oncol Hematol 54:63-75. 2005
    ..This review summarizes recent advances made towards understanding the signaling mechanisms by which Epo-R and c-Kit regulate growth, survival, and differentiation of erythroid progenitors alone and cooperatively...
  82. ncbi Both proteasomes and lysosomes degrade the activated erythropoietin receptor
    Pierre Walrafen
    Departement d Hematologie, Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, Paris, France
    Blood 105:600-8. 2005
    ..The efficiency of these processes probably explains the short duration of intracellular signaling activated by Epo...
  83. ncbi Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis
    Suzanne Burns
    South Texas Veterans Health Care System, and Department of Medicine, Division of Hematology, University of Texas Health Science Center, San Antonio, TX, USA
    Blood 99:4400-5. 2002
    ..Yeast-expressed Epo (R103A) is a specific inhibitor of primary erythropoiesis suitable for testing in animal models...
  84. ncbi Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment
    Michael I Assaraf
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    J Neuropathol Exp Neurol 66:389-98. 2007
    ..We conclude that upregulation of EpoR in temporal cortical and hippocampal astrocytes is an early, potentially neuroprotective, event in the pathogenesis of sporadic AD...
  85. pmc Activation of erythropoietin receptors by Friend viral gp55 and by erythropoietin and down-modulation by the murine Fv-2r resistance gene
    M E Hoatlin
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098
    Proc Natl Acad Sci U S A 87:9985-9. 1990
    ..leukemogenic membrane glycoprotein (gp55) encoded by Friend spleen focus-forming virus appears to bind to erythropoietin receptors (EpoR) sto stimulate erythroblastosis [Li, J.-P., D'Andrea, A.D., Lodish, H.F. & Baltimore, D...
  86. ncbi Biology of erythropoietin
    C Lacombe
    Institut National de la Sante et de la Recherche Medicale, Unité 363, ICGM, Universite Rene Descartes, Paris, France
    Haematologica 83:724-32. 1998
    ..Furthermore, target disruption of both Epo and Epo receptor showed that Epo was not involved in the commitment of the erythroid lineage and seemed to act mainly as a survival factor...
  87. pmc Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia
    Jorge Soliz
    Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland, and Center de Recherché, Hôpital St François d Assise, Quebec, Canada
    J Physiol 583:329-36. 2007
    ....
  88. pmc Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia
    R Kralovics
    University of Alabama at Birmingham, Division of Hematology Oncology, Birmingham, Alabama 35294 0006, USA
    J Clin Invest 102:124-9. 1998
    ..Failure of this child to develop polycythemia suggests the existence of as yet unidentified environmental or genetic factors that may suppress disease development...
  89. ncbi The intron 5-inserted form of rat erythropoietin receptor is expressed as a membrane-bound form
    R Yamaji
    Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Biochim Biophys Acta 1403:169-78. 1998
    ....
  90. doi A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene
    Maha Al-Sheikh
    INSERM, U841, Creteil, France
    Haematologica 93:1072-5. 2008
    ..6146A>G (p.Asn487Ser)] and another, a silent one (g.5799G>A). All were heterozygotes. In addition, 2 patients were positive for JAK2 (Val617Phe), and 2 reported elsewhere, were mutated in the PHD2 gene [c.606delG (p.Met202IlefsX71)...
  91. ncbi Cell surface site for mitogenic interaction of erythropoietin receptors with the membrane glycoprotein encoded by Friend erythroleukemia virus
    F E Ferro
    Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health Sciences University, Portland 97201 3098
    J Biol Chem 268:5741-7. 1993
    ..Recent evidence suggested that gp55 binds to erythropoietin receptors (EpoR) in the RER, and it was proposed that this intracellular interaction causes mitogenesis (Li, J.-P...
  92. doi Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia
    Raja El Hasnaoui-Saadani
    Universite Paris, Bobigny, France
    Am J Physiol Regul Integr Comp Physiol 296:R801-11. 2009
    ..levels of hypoxia-inducible factor 1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), erythropoietin receptors (EpoR), phospho-STAT-5/STAT-5 ratio, and neuronal neuronal nitric oxide synthase (nNOS) along with a ..
  93. doi Erythropoietin receptors on tumor cells: what do they mean?
    Joachim Fandrey
    Institut fur Physiologie, Universitat Duisburg Essen, Hufelandstr 55, D 45147 Essen, Germany
    Oncologist 13:16-20. 2008
    Given the apparent presence of erythropoietin receptors (EPORs) in cancer tissues, questions have been raised about the possible influence of erythropoiesis-stimulating agents (ESAs) on tumor growth and proliferation...
  94. doi The non-haematopoietic biological effects of erythropoietin
    Murat O Arcasoy
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Br J Haematol 141:14-31. 2008
    ..This review focuses on the scientific evidence documenting the biological effects of Epo in non-haematopoietic tissues and discusses potential future applications of Epo and its derivatives in the clinic...
  95. ncbi Do cancer cells express functional erythropoietin receptors?
    Gregory D Longmore
    Washington University, St Louis, USA
    N Engl J Med 356:2447. 2007
  96. ncbi The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p
    J C Winkelmann
    Department of Medicine, University of Minnesota, Minneapolis
    Blood 76:24-30. 1990
    ..The human Epo receptor gene is localized to human chromosome 19p by in situ hybridization. This chromosome assignment is confirmed by hybridization to a panel of sorted human chromosomes...
  97. ncbi Problems in identifying functional erythropoietin receptors in cancer tissue
    Wolfgang Jelkmann
    J Clin Oncol 25:1627-8; author reply 1628. 2007
  98. pmc Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function
    Stephane Pelletier
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell Biol 26:8527-38. 2006
    ..Collectively, the results suggest that Jak2 is the sole direct signaling molecule downstream of EpoR required for biological activity...
  99. ncbi Isolation of a cDNA encoding a potential soluble receptor for human erythropoietin
    K Todokoro
    Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Gene 106:283-4. 1991
    ..Analysis of human erythropoietin receptor-encoding cDNAs revealed the possible existence of a soluble receptor lacking the transmembrane and cytoplasmic domains...
  100. ncbi Preclinical studies of erythropoietin receptor expression in tumour cells: impact on clinical use of erythropoietic proteins to correct cancer-related anaemia
    Anders Osterborg
    Department of Oncology, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Cancer 43:510-9. 2007
    ..Together with diverging results in the literature, these methodological limitations indicate that findings from preclinical studies must not be over-translated in terms of their clinical relevance to patients with cancer...
  101. ncbi An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: a cytokine receptor superfamily oncogene
    G D Longmore
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
    Cell 67:1089-102. 1991
    ..The activated erythropoietin receptor does not transform cultured fibroblasts, suggesting why oncogenic mutations in other members of this receptor superfamily have not been detected...

Research Grants79

  1. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2009
    ..These studies will have a critical impact on our understanding of mechanisms of different types of anemias and how to increase red blood cell production. ..
  2. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2010
    ..These studies will have a critical impact on our understanding of mechanisms of different types of anemias and how to increase red blood cell production. ..
  3. IN VIVO SIGNALING OF THE ERYTHROPOIETIN RECEPTOR
    Saghi Ghaffari; Fiscal Year: 2002
    ....
  4. Erythropoietin receptor /Janus Kinase 2 complex
    Lily Huang; Fiscal Year: 2006
    ..Through this research proposal, the applicant will receive training in biophysical and structural biology and will gain the necessary skills and knowledge to become an independent investigator. ..
  5. ERYTHROPOIETIN RECEPTOR REGULATION OF ERYTHROPOIESIS
    MURAT ARCASOY; Fiscal Year: 2002
    ....
  6. Molecular Biology of Polycythemia
    Josef Prchal; Fiscal Year: 2007
    ..Aim 3 Determine the genetic and molecular basis for congenital polycythemias characterized by elevated Epo concentrations and mutations of other than the VHL gene. ..
  7. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    b>Erythropoietin receptors are present on intestinal cells of the human fetus and neonate...
  8. Characterization of a Novel Erythropoietin Signaling Pathway
    Adam N Goldfarb; Fiscal Year: 2010
    ..One specific topic listed in this announcement is "Non-erythroid Expression and Function of Erythropoietin Receptors." A significant component of this project will be devoted to analysis of myocardial PKD activation by Epo ..
  9. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    Daniel DiMaio; Fiscal Year: 2010
    ..In addition, on the basis of these studies, we will continue to develop a novel protein engineering method to control biological processes, including infection by human immunodeficiency virus, an important co-factor in many cancers. ..
  10. Role of NIX in Erythroid Maturation
    PAUL NEY; Fiscal Year: 2007
    ..We propose to explore that possibility in experiments with Nix mice and other BCL2-related mouse strains. ..
  11. Fetal Stem Cell Gene Therapy
    MARCUS MUENCH; Fiscal Year: 2003
    ..A positive outcome from the proposed studies would aid in developing treatments for hemoglobinopathies based on generating hematopoietic allochimerism. ..
  12. Erythropoietin receptor signaling in erythropoiesis
    Lily Huang; Fiscal Year: 2009
    ..Information gained from these studies will lead to a more comprehensive understanding of how EpoR signaling regulates erythropoiesis and how oncogenic EpoR and JAK2 activation induces leukemia. ..
  13. Role of Erythropoietin receptor signaling in heart
    MURAT ARCASOY; Fiscal Year: 2004
    ..abstract_text> ..
  14. Erythropoietin Blockade for the Treatment of Cancer
    C Anthony Blau; Fiscal Year: 2010
    ..First, we will develop a diagnostic assay to predict which patients are most susceptible to erythropoietin induced tumor growth. Second, we propose a new strategy for treating tumors that is based on erythropoietin blockade. ..
  15. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara Miller; Fiscal Year: 2006
    ..TRPC2 knockout mice will be used to examine the rote of TRPC2 in viability, proliferation, apoptosis induction and cell cycle progression of primary erythroid cells. ..
  16. Erythropoietin Blockade for the Treatment of Cancer
    C Anthony Blau; Fiscal Year: 2009
    ..First, we will develop a diagnostic assay to predict which patients are most susceptible to erythropoietin induced tumor growth. Second, we propose a new strategy for treating tumors that is based on erythropoietin blockade. ..
  17. ROLE OF FV2 IN ERYTHROPOIESIS
    PAUL NEY; Fiscal Year: 2004
    ..These studies should improve our understanding of normal hematopoiesis and leukemic transformation. ..
  18. XRAY STUDIES OF EPO AND IL2 RECEPTOR COMPLEXES
    Ian Wilson; Fiscal Year: 2001
    ..The crystallographic study of IL-2 mutants and various forms of the receptor complex should give insights into the structure and function of this key receptor in T cell growth and proliferation. ..