Genomes and Genes
Summary: Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.
Publications307 found, 100 shown here
- The evolution of vertebrate antigen receptors: a phylogenetic approachM H Richards
Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada
Mol Biol Evol 17:146-55. 2000..Analyses of the variable regions are complicated by strong selection on antigen-binding sequences, but imply that direct antigen binding is the ancestral condition...
- The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectinL M Schnapp
Department of Medicine, University of California, San Francisco 94143, USA
J Biol Chem 270:23196-202. 1995....
- Crystal structure of a shark single-domain antibody V region in complex with lysozymeRobyn L Stanfield
Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 305:1770-3. 2004..Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, ..
- Rapid isolation of IgNAR variable single-domain antibody fragments from a shark synthetic libraryCui Ying Shao
Department of Molecular and Cell Biology, Foresterhill, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
Mol Immunol 44:656-65. 2007..The results here demonstrate that a synthetic IgNAR variable domain library based on a single framework scaffold can be used as a route to generate antigen binders quickly, easily and without the need of immunization...
- Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early developmentMarilyn Diaz
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Immunogenetics 54:501-12. 2002....
- A naturally occurring NAR variable domain binds the Kgp protease from Porphyromonas gingivalisStewart D Nuttall
CSIRO Health Sciences and Nutrition, 343 Royal Parade, 3052, Parkville, Vic, Australia
FEBS Lett 516:80-6. 2002..Binding localised to the Kgp adhesin domains, however without inhibiting adhesin activity. These naturally occurring proteins indicate an immune response to pathogenic bacteria and suggest that the NAR is a true antibody-like molecule...
- Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safeP J Fink
University of Washington, Dept of Immunology, Seattle, WA 98195, USA
Immunol Today 21:561-6. 2000Pamela Fink and Catherine McMahan discuss how B and T cells test for useful antigen receptors and weed out potentially harmful ones, with special attention paid to T-cell receptor revision, a newly described mechanism by which mature T ..
- Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptorsTakashi Suzuki
Department of Biosystems Science, School of Advanced Sciences, Graduate University for Advanced Studies SOKENDAI, Hayama, Japan
J Immunol 174:2885-91. 2005..The extracellular domain of APAR may be descended from a V-type domain postulated to have acquired recombination signal sequences in a jawed vertebrate lineage...
- The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-CB Varnum-Finney
Department of Physiology, University of California, San Francisco 94143 0724, USA
Neuron 14:1213-22. 1995..The major domain in tenascin that mediates neurite outgrowth is shown to be localized to fibronectin type III repeats 6-8...
- Organisation and dynamics of antigen receptors: implications for lymphocyte signallingBebhinn Treanor
London Research Institute, Cancer Research UK, London, UK
Curr Opin Immunol 22:299-307. 2010..Here, we discuss recent findings on the regulation of steady-state organisation and diffusion dynamics of immunoreceptors, and how this might impact on our understanding of basal and ligand-dependent signalling...
- Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage displayHelen Dooley
Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
Mol Immunol 40:25-33. 2003..This approach can therefore be considered as an alternative route for the isolation of minimal antigen-binding fragments with favorable characteristics...
- Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop librariesS D Nuttall
CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
Mol Immunol 38:313-26. 2001..Thus, the New Antigen Receptor represents a protein scaffold with possible stability advantages over conventional antibodies when used in in vitro molecular libraries...
- Transducing signals from antigen receptors to nuclear factor kappaBJurgen Ruland
Advanced Medical Discovery Institute, Ontario Cancer Institute and University of Toronto, Toronto, ON, Canada
Immunol Rev 193:93-100. 2003..Bcl-10 is known to participate in chromosomal translocations in human mucosa-associated lymphoid tissue lymphomas...
- T cell-specific loss of Pten leads to defects in central and peripheral toleranceA Suzuki
Department of Molecular and Cellular Biology, Osaka University, 565 0871, Osaka, Japan
Immunity 14:523-34. 2001..Peripheral tolerance to SEB is also impaired in Pten(flox/-) mice. PTEN is thus an important regulator of T cell homeostasis and self-tolerance...
- The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2V Aidinis
Howard Hughes Medical Institute, Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Cell Biol 19:6532-42. 1999..A transient increase of HMG1,2 concentration in transfected cells increases the production of the final V(D)J recombinants in vivo...
- V(D)J recombination: RAG proteins, repair factors, and regulationMartin Gellert
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 0540, USA
Annu Rev Biochem 71:101-32. 2002..This transposition helps to explain the mechanism of RAG action and supports earlier proposals that V(D)J recombination evolved from an ancient mobile DNA element...
- Scaffolding of antigen receptors for immunogenic versus tolerogenic signalingJesse E Jun
Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
Nat Immunol 4:1057-64. 2003Lymphocyte antigen receptors are responsible for inducing the opposite responses of immunity or tolerance. How the correct polarity of antigen receptor signaling is encoded has been an enduring enigma...
- HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependentAleksei N Kriatchko
Department of Medical Microbiology and Immunology, Creighton University Medical Center, 2500 California Plaza, Omaha, NE, USA
BMC Mol Biol 9:32. 2008..Here we test whether this apparent discrepancy is attributed to the choice of divalent metal ion and the concentration of HMGB1 used in the cleavage reaction...
- Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?"Gianpietro Dotti
Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital, Houston, TX 77030, USA
Hum Gene Ther 20:1229-39. 2009..In this review we summarize the concept of CAR-based immunotherapy, describe the steps accomplished, and outline the future progress we need to make if this approach is truly to improve cancer immunotherapy...
- Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminaseIgor B Rogozin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Nat Immunol 8:647-56. 2007..Vertebrate acquired immunity could have therefore originated from lymphocyte receptor diversification by an ancestral AID-like DNA cytosine deaminase...
- Positive versus negative signaling by lymphocyte antigen receptorsJ I Healy
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305, USA
Annu Rev Immunol 16:645-70. 1998b>Antigen receptors on lymphocytes play a central role in immune regulation by transmitting signals that positively or negatively regulate lymphocyte survival, migration, growth, and differentiation...
- Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growthCheryl A Doughty
Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
Blood 107:4458-65. 2006..Manipulation of these pathways may prove to be useful in the treatment of lymphoproliferative disorders, wherein clonal expansion of B lymphocytes plays a role...
- Binding of HIV-1 to RBCs involves the Duffy antigen receptors for chemokines (DARC)A Lachgar
Laboratoire de Physiologie Cellulaire, Universite P et M Curie, Paris, France
Biomed Pharmacother 52:436-9. 1998..This finding suggests that RBCs may function as a reservoir for HIV-1 or as a receptor for the entry of HIV-1 into CD4-cell subsets as well as neurons or endothelial cells...
- From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-kappaBJurgen Ruland
Advanced Medical Discovery Institute, Ontario Cancer Institute and University of Toronto, 620 University Avenue, Toronto, Ont, Canada M5G 2C1
Semin Immunol 15:177-83. 2003..signal transduction pathways leading to NF-kappaB activation that are triggered by engagement of the antigen receptors of T and B cells...
- Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptorV A Streltsov
Division of Health Sciences and Nutrition, Commonwealth Scientific and Industrial Research Organization, and Cooperative Research Centre for Diagnostics, 343 Royal Parade, Parkville 3052, Australia
Proc Natl Acad Sci U S A 101:12444-9. 2004The Ig new antigen receptors (IgNARs) are single-domain antibodies found in the serum of sharks. Here, we report 2.2- and 2.8-A structures of the type 2 IgNAR variable domains 12Y-1 and 12Y-2...
- Selection of cholera toxin specific IgNAR single-domain antibodies from a naïve shark libraryJinny L Liu
Center for Bio Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC 20375, USA
Mol Immunol 44:1775-83. 2007..The successful isolation of target specific sdAbs from one of our non-biased NAR libraries, demonstrate their ability to provide binders against an unacquainted antigen of interest...
- Antigen receptor signaling: the Tuscan connectionCosima T Baldari
Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
Nat Immunol 8:787-90. 2007
- CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transductionC Kung
Howard Hughes Medical Institute, Department of Pathology and Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
Eur J Immunol 29:3951-5. 1999CD45 is a transmembrane protein tyrosine phosphatase required for signaling through the T-and B-cell antigen receptors. In lymphocytes, CD45 interacts with CD45-associated protein (CD45AP), a 32 000 Mr phosphoprotein, through their ..
- Direct measurement of lymphocyte receptor diversityBrenda M Ogle
Transplantation Biology Program, Department of Physiology, Mayo Clinic, Rochester, Minnesota, MN 55905, USA
Nucleic Acids Res 31:e139. 2003..In addition, this approach could be more broadly applied, for example to measure diversity of viral quasi-species...
- Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70Stewart D Nuttall
CSIRO Health Sciences and Nutrition, Parkville, Victoria, Australia
Eur J Biochem 270:3543-54. 2003....
- Chromatin modifications as clues to the regulation of antigen receptor assemblyDavid Ciccone
Department of Molecular Biology, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
Novartis Found Symp 259:146-58; discussion 158-69. 2004..The specific patterns of modification imply that the regulation of V(D)J recombination involves recruitment of specific methyltransferases in a localized manner...
- T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segmentsE Kraig
J Exp Med 158:192-209. 1983..Furthermore, the presence of idiotypic determinants on T lymphocytes does not necessarily imply close structural similarity between T and B cell antigen receptors.
- Genetic dissection of antigen receptor induced-NF-kappaB activationZhi Wei Li
H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 3011 West Holly Drive, SRB 22344, Tampa, FL 33612, USA
Mol Immunol 41:701-14. 2004..This review addresses the cell signaling from antigen receptors as well as Toll-like receptors to NF-kappaB in both innate and adaptive immunity as revealed by the analysis ..
- High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemiasS Hubner
Children s Cancer Research Institute, St Anna Kinderspital, Vienna, Austria
Leukemia 18:84-91. 2004....
- Somatic diversification of variable lymphocyte receptors in the agnathan sea lampreyZeev Pancer
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nature 430:174-80. 2004..are apparently capable of adaptive immune responses, they have not been found to possess the recombinatorial antigen receptors shared by all jawed vertebrates...
- Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cellsL L Lanier
DNAX Research Institute of Molecular and Cellular Biology, Department of Immunobiology, Palo Alto, California 94304, USA
Nature 391:703-7. 1998..Phosphorylated DAP12 peptides bind ZAP-70 and Syk protein tyrosine kinases, suggesting that the activation pathway is similar to that of the T- and B-cell antigen receptors.
- Defective antigen receptor-mediated proliferation of B and T cells in the absence of VavA Tarakhovsky
Institute for Genetics, University of Cologne, Germany
Nature 374:467-70. 1995Crosslinking of B- or T-cell antigen receptors results in the rapid tyrosine phosphorylation of a number of proteins, including Vav, a protein expressed in cells of the haematopoietic system...
- ATM prevents unattended DNA double strand breaks on site and in generations to comeBu Yin
Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Cancer Biol Ther 6:1837-9. 2007..Collectively, these results have provided complementary mechanistic insights into ATM functions in V(D)J recombination that can account for the lymphoid tumor-prone phenotype associated with A-T...
- Mechanisms of antigen receptor evolutionDonna D Eason
Department of Pediatrics, Children s Research Institute, University of South Florida College of Medicine, 830 First Street South, St Petersburg, FL 33701, USA
Semin Immunol 16:215-26. 2004..Homologs of immunoglobulins (Igs), T cell antigen receptors (TCRs), major histocompatibility complex (MHC) I and II, and the recombination activating genes (RAGs) have ..
- Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subcloneSeoyeon Choi
Children s Cancer Institute Australia for Medical Research, Sydney, Australia
Blood 110:632-9. 2007..Relapse prediction may be improved with strategies to detect minor potentially resistant subclones early during treatment, hence allowing intensification of therapy...
- Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closureJ Ruland
Amgen Institute, 620 University Avenue, Toronto, Ontario, Canada M5G 2C1
Cell 104:33-42. 2001..Thus, Bcl10 functions as a positive regulator of lymphocyte proliferation that specifically connects antigen receptor signaling in B and T cells to NF-kappaB activation...
- Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFkappaB activity in vertebrate B-cellsPing Liu
Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK
FEBS Lett 581:1377-82. 2007..Thus, PKDs have a selective role in DT40 B-cell biology...
- MHC class II signaling in antigen-presenting cellsReem Al-Daccak
Institut Universitaire d Hematologie, IFR105, Hôpital Saint Louis AP HP, 10 rue Claude Vellefaux, 75475 Paris, France
Curr Opin Immunol 16:108-13. 2004..Recent advances have provided insights into how these molecules might accommodate such regulation...
- CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturationK F Byth
Department of Pathology, Cambridge University, United Kingdom
J Exp Med 183:1707-18. 1996..We conclude that CD45 is not required at any stage during the generation of mature peripheral B cells, however its loss reveals a previously unrecognized role for CD45 in the regulation of certain subpopulations of B cells...
- Immunology: another manifestation of GODMartin F Flajnik
Nature 430:157-8. 2004
- Shattuck lecture: Diversity of the immune repertoire and immunoregulationRobert S Schwartz
N Engl J Med 348:1017-26. 2003
- The Vav family: at the crossroads of signaling pathwaysWojciech Swat
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Immunol Res 32:259-65. 2005..exchange factors (GEFs) is thought to control a diverse array of signaling pathways emanating from antigen receptors in lymphocytes, although the exact mechanism by which Vav exerts its function is only beginning to emerge...
- Unraveling V(D)J recombination; insights into gene regulationDavid Jung
Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, Inc, Harvard Medical School, Boston, MA 02115, USA
Cell 116:299-311. 2004....
- Antibody responses of variable lymphocyte receptors in the lampreyMatthew N Alder
Office of Fundamental Immunology Research, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA
Nat Immunol 9:319-27. 2008..Lacking a thymus and the ability to respond to soluble protein antigens, lampreys seem to have evolved a B cell-like system for adaptive humoral responses...
- Homeostatic control of lymphocyte survival: potential origins and implicationsDavid R Plas
Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Nat Immunol 3:515-21. 2002....
- Pathways for self-tolerance and the treatment of autoimmune diseasesC C Goodnow
Australian Cancer Research Foundation, Genetics Laboratory, Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Lancet 357:2115-21. 2001..New experimental therapies aim to mimic tolerogenic antigen signals by chronically stimulating antigen receptors with antigen or antibodies to the receptor, or aim to block costimulatory pathways involving CD40 ligand, B7,..
- Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3KKlaus Okkenhaug
Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK, CB2 4AT
Trends Immunol 28:80-7. 2007The activation of antigen receptors triggers two important signalling pathways originating from phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P(2)]...
- A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangementYun Liu
Department of Molecular Biology and Genetics, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Immunity 27:561-71. 2007..Together, these findings are consistent with the interpretation that recognition of hypermethylated histone H3 K4 promotes efficient V(D)J recombination in vivo...
- CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cellsBirgitta Messmer
Institute for Immunology, University of Heidelberg, Heidelberg, Germany
J Immunol 176:4646-50. 2006..This demonstrates that 2B4 can stimulate NK cell cytotoxicity and cytokine production by interacting with NK cell expressed CD48 and adds CD48 to the growing number of activating NK cell receptors...
- Immunoglobulins in the eggs of the nurse shark, Ginglymostoma cirratumAshley N Haines
Department of Microbiology and Immunology, School of Medicine, University of Maryland, 655 W Baltimore Street, Rm 13 009, Baltimore, MD 21202, USA
Dev Comp Immunol 29:417-30. 2005..Using monoclonal antibodies, we establish the presence of two classes of Igs in nurse shark eggs: 7S IgM and IgNAR. The potential transfer of immunoglobulins from elasmobranch eggs is discussed...
- [Chromatin dynamics in gene rearrangement]Yasutoshi Agata
Tanpakushitsu Kakusan Koso 51:315-25. 2006
- SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinationsJoseph M Volpe
Computational Biology and Bioinformatics Program, Duke University Medical Center Box 90090 Duke University, Durham, NC 27708 0090, USA
Bioinformatics 22:438-44. 2006The antigen receptors of adaptive immunity-T-cell receptors and immunoglobulins-are encoded by genes assembled stochastically from combinatorial libraries of gene segments...
- CD38 is expressed on human mature monocyte-derived dendritic cells and is functionally involved in CD83 expression and IL-12 inductionGiorgio Fedele
Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
Eur J Immunol 34:1342-50. 2004..Activation via agonistic anti-CD38 mAb induces up-regulation of CD83 expression and IL-12 secretion, whereas disruption of CD38/CD31 interaction inhibits CD83 expression, IL-12 secretion and MDDC-induced allogeneic T cell proliferation...
- B cell antigen receptor signaling enhances IFN-gamma-induced Stat1 target gene expression through calcium mobilization and activation of multiple serine kinase pathwaysWeifeng Xu
Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
J Interferon Cytokine Res 25:113-24. 2005..These studies demonstrate that a wide variety of noncytokine signaling pathways can modulate cytokine signaling through modulation of Stat1 serine phosphorylation...
- Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signalingWhitney E Purtha
Departments of Medicine, Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St Louis, MO 63110, USA
J Virol 82:10964-74. 2008....
- Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65D Yablonski
Department of Pharmacology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Bat Galim, Haifa 31096, Israel
Adv Immunol 79:93-128. 2001....
- Retargeting of natural killer-cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destructionChristoph Uherek
Chemotherapeutisches Forschungsinstitut Georg Speyer Haus, Frankfurt am Main, Germany
Blood 100:1265-73. 2002..These results demonstrate that efficient retargeting of NK-92 cytotoxicity can be achieved and might allow the generation of potent cell-based therapeutics for the treatment of ErbB2-expressing malignancies...
- The MAGUK family protein CARD11 is essential for lymphocyte activationHiromitsu Hara
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 7, A 1030, Vienna, Austria
Immunity 18:763-75. 2003..Our results show that the same family of molecules are critical regulators of neuronal synapses and immune receptor signaling...
- Basic and tumor immunology: a reviewRoger W Melvold
Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202 9037, USA
Surg Oncol Clin N Am 16:711-35, vii. 2007..We are also learning about how it communicates with the environment and how its various components interact within the body. With this information, we are learning how to manipulate it to our greater benefit...
- Finally, MALT1 is a protease!Linda M McAllister-Lucas
Nat Immunol 9:231-3. 2008
- Phosphorylation of CARMA1: the link(er) to NF-kappaB activationDaniel Rueda
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Immunity 23:551-3. 2005..Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-kappaB...
- Affinity-dependent alterations of mouse B cell development by noninherited maternal antigenCecile Vernochet
Laboratory of Immune Regulations and Development, J Monod Institute, Paris, France
Biol Reprod 72:460-9. 2005..Thus, we show that fetal and neonatal B cell development is affected by maternal cells bearing antigens noninherited by the fetus and that this phenomenon is highly dependent on the affinity of the B cell receptor for the NIMA...
- Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3R R Rivera
Department of Biology, 0366 University of California, San Diego, La Jolla 92093, USA
Immunity 12:17-26. 2000..Finally, we show that E2A and Id3 interact genetically to regulate thymocyte development. These observations identify the HLH inhibitory protein Id3 as an essential component required for proper thymocyte maturation...
- Detection of receptor trimers on the cell surface by flow cytometric fluorescence energy homotransfer measurementsLaszlo Bene
Department of Biophysics and Cell Biology, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Hungary
Biochim Biophys Acta 1744:176-98. 2005....
- Bridging B cell and T cell recognition of antigenHidde L Ploegh
J Immunol 179:7193. 2007
- [Studies on the relationship between unexplained recurrent spontaneous abortion and immunotolerance at the maternal-fetal interface]Qi De Lin
Zhonghua Fu Chan Ke Za Zhi 41:145-7. 2006
- Effect of CpG methylation on RAG1/RAG2 reactivity: implications of direct and indirect mechanisms for controlling V(D)J cleavageHiroshi Nakase
Institute for Genome Research, University of Tokushima, Japan
EMBO Rep 4:774-80. 2003....
- A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytesBarbara L Rellahan
Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, NIH, Bethesda, MD 20892, USA
Exp Cell Res 289:184-94. 2003..The interaction of c-Cbl with PLCgamma1 may negatively effect events required for PLCgamma1 activation...
- Detection of monoclonal immunoglobulin heavy chain gene rearrangement (FR3) in Thai malignant lymphoma by High Resolution Melting curve analysisTanawan Kummalue
Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Bangkok 10700, Thailand
Diagn Pathol 5:31. 2010..In conclusion, the detection IgH gene rearrangement by HRM in the LightCycler System showed potential for distinguishing monoclonality from polyclonality in B-cell non-Hodgkin lymphoma...
- Extracellular purines and their receptors in immunoregulation. Review of recent advancesM V Sitkovsky
Laboratory of Immunology, NIAID, NIH, Bethesda, MD 20892, USA
Nihon Ika Daigaku Zasshi 65:351-7. 1998..g. affecting TCR-multimolecular complex formation and antigen binding affinity. It is suggested that TCR ectodomain phosphorylation could serve as a potential mechanism for regulation of TCR-mediated T-lymphocytes response...
- AKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domainP Rieske
Department of Biochemistry, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102, USA
J Biol Chem 276:8460-8. 2001..Consistent with these studies, ligation of antigen receptors in A20 B cells mimics AKT activation of PU.1. Taken together, these results provide evidence that PU...
- Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulationDaniel J Bolland
Laboratory of Chromatin and Gene Expression, Babraham Institute, Babraham Research Campus, Cambridge, UK
Adv Exp Med Biol 650:59-72. 2009....
- [Effects of immunosuppressive treatment in prevention of calcification in aortic valved homograft: experiment with rats]Xing jun Gong
Department of Cardiac Surgery, Qilu Hospital, Shandong University, Jinan 250012, China
Zhonghua Yi Xue Za Zhi 87:2132-5. 2007..To investigate the effects of immunosuppressive treatment in prevention of calcification in aortic valved homograft (AVH)...
- Selected problems of malaria blood stage immunityP Perlmann
Department of Immunology, Stockholm University, Sweden
Tokai J Exp Clin Med 23:55-62. 1998..falciparum in human malaria...
- Co-ordinate action of bacterial adhesins and human carcinoembryonic antigen receptors in enhanced cellular invasion by capsulate serum resistant Neisseria meningitidisHelen A Rowe
Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Cell Microbiol 9:154-68. 2007....
- Southeast Asian ovalocytosis is associated with increased expression of Duffy antigen receptor for chemokines (DARC)I J Woolley
Department of Infectious Diseases, Monash Medical Centre and Monash University, Clayton, Victoria, Australia
Immunohematology 25:63-6. 2009..61 +/- 19.12 for SAO heterozygotes and 16.47 +/- 3.81 for controls. SAO is associated with increased and not decreased Fy6 expression so that susceptibility to P. vivax infection is unlikely to be affected...
- Major histocompatibility complex independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptorC R Hewitt
Imperial Cancer Research Fund, London, UK
J Exp Med 175:1493-9. 1992..We conclude that SEB interacts directly with the TCR in the absence of cointeraction with MHC class II molecules, and that this interaction may induce anergy in HA1.7...
- Preclinical results of sirolimus treatment in transplant modelsS M Stepkowski
Division of Immunology and Organ Transplantation, Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
Transplant Proc 35:219S-226S. 2003..Furthermore, CsA potentiated SRL-mediated toxicities, namely myelosuppression and increased cholesterol. In conclusion, SRL therapy is synergistic with CsA but both drug levels should be carefully monitored to avoid toxic effects...
- The related molecular chaperones calnexin and calreticulin differentially associate with nascent T cell antigen receptor proteins within the endoplasmic reticulumJ E van Leeuwen
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
J Biol Chem 271:25345-9. 1996..These studies identify calreticulin as a molecular chaperone for nascent clonotypic TCRalpha and -beta proteins and demonstrate that calreticulin and calnexin differentially associate with newly synthesized TCR proteins within the ER...
- Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complexS Vasile
Department of Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
Mol Immunol 31:419-27. 1994..In addition, we found that there is a strong amino acid sequence homology between the microtubule-binding domains of certain human microtubule-associated proteins and an intracellular segment of the human mb-1 protein...
- Temporal ordering of caspase activation and substrate cleavage during antigen receptor-triggered apoptosis in Ramos-Burkitt lymphoma B cellsSungkwan An
Department of Biochemistry, University of Oxford, UK
Int J Oncol 23:257-68. 2003..An understanding of the role played by caspases in the execution of apoptosis may provide insight into the pathogenesis of these disease states and thereby provide targets for novel therapeutic strategy...
- Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell linesS Lew
Department of Microbiology, Molecular and Cellular Biology Program, Arizona State University, Tempe, Arizona 85287 2701, USA
Mol Cell Biol 20:7170-7. 2000..These data suggest that an inability of scid cells to promptly resolve their recombination ends exposes the ends to a random joining process, which can conceivably lead to chromosomal translocations...
- Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cellsAnne E Lieberman
Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA
BMC Immunol 10:37. 2009..These results are inconsistent with a model of cRS cleavage during autoreactivity-induced VH gene replacement...
- Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosisChristina L Addison
Departments of Medicine, Pathology, and Pediatrics, Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles CA, 90024 1922 USA
BMC Cancer 4:28. 2004....
- Differential role of reactive oxygen species in the activation of mitogen-activated protein kinases and Akt by key receptors on B-lymphocytes: CD40, the B cell antigen receptor, and CXCR4Rosaline L Lee
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
J Cell Commun Signal 1:33-43. 2007..We focused on activation of ERK, JNK, p38, and Akt, kinases that regulate multiple processes including cell survival, proliferation, and migration...
- The structural basis for autonomous dimerization of the pre-T-cell antigen receptorSiew Siew Pang
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Nature 467:844-8. 2010..This unusual dual-chaperone-like sensing function of pre-Tα represents a unique mechanism in nature whereby developmental quality control regulates the expression and signalling of an integral membrane receptor complex...
- Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytesJ Zhang
Department of Medicine, University of Toronto, Ontario, Canada M5G 1X5
J Exp Med 190:1329-42. 1999..The data also reveal a role for WASp in modulating endocytosis and phagocytosis and, accordingly, suggest that the immune deficit conferred by WASp deficiency reflects the disruption of a broad range of cellular behaviors...
- Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrestM C Horne
Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, USA
J Biol Chem 272:12650-61. 1997..These results suggest that in murine B cells responding to growth inhibitory stimuli cyclin G2 may be a key negative regulator of cell cycle progression...
- Immunoglobulin superfamily receptors in protochordates: before RAG timeLouis Du Pasquier
Institute of Zoology, University of Basel, Basel, Switzerland
Immunol Rev 198:233-48. 2004..They use the domains typical of vertebrate antigen receptors and class I and II: the V, and C1-like domains...
- B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganismsQ Vos
Department of Medicine, Uniformed Services, University of the Health Sciences, Bethesda, Maryland, USA
Immunol Rev 176:154-70. 2000..of pathogens in an organized, highly repetitive form can activate specific B cells by cross-linking of antigen receptors in a multivalent fashion...
- A negative role for phosphoinositide 3-kinase in T-cell antigen receptor functionK Reif
Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
Curr Biol 7:285-93. 1997..In this study, we investigated the importance of PI 3-kinase in TCR-directed T-cell activation using activated or inhibitory versions of PI 3-kinase...
- Activation of Valpha24NKT cells in malignant pleural effusion in patients with lung cancerTetsuo Shimizu
Department of Respiratory Medicine, Nihon University School of Medicine, 173 8610 Tokyo, Japan
Oncol Rep 22:581-6. 2009Valpha24NKT cells are lymphocytes expressing both T-cell antigen receptors and NK-cell antigen receptors on their cell surface and are involved in tumor immunity...
- Association between Duffy antigen receptor for chemokines expression and levels of inflammation markers in sickle cell anemia patientsDanitza Nebor
UMR S_763 Inserm Université des Antilles et de la Guyane, Hôpital RICOU, CHU de Pointe a Pitre, 97159 Pointe a Pitre, Guadeloupe
Clin Immunol 136:116-22. 2010..46+/-1.22 vs 1.47+/-0.5 pg/mL, p=0.0202) and RANTES (27.8+/-4.3 vs 18.1+/-2.3 ng/mL, p=0.04) than Duffy-negative patients. No association was detected between RBC expression of DARC and the studied complications...
- ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinityN Isakov
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
J Exp Med 181:375-80. 1995..The cooperativity ensures higher affinity for the doubly phosphorylated ligand. Affinity differences of as much as 30-fold indicates a significant specificity of interaction of ZAP-70 SH2 domains for different phospho-TAMs...
- A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1-induced lethal shock in V beta 8.2 T-cell receptor transgenic miceC M Cullen
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45267, USA
Pathobiology 63:293-304. 1995..Although induction of toxic shock is clearly associated with T-cell proliferation, defects in fas antigen receptor or ligand may also contribute substantively to superantigen-mediated lethal shock by still undefined mechanisms...
- CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1J J Perez-Villar
Immunology and Inflammation Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
Mol Cell Biol 19:2903-12. 1999..These results suggest a critical role of the CD5 ITIM-like motif, which by binding to SHP-1 mediates the down-regulatory activity of this receptor...
- Regulation of B Cell Function by Membrane-Cytoskeletal RemodelingNeetu Gupta; Fiscal Year: 2012..Lessons learnt from understanding the role of ezrin in B cell function can be applied towards therapeutic design for B cell-dependent human diseases. ..
- In Vivo Function of TRAF6 As a Target of K63-Linked PolyubiquitinationDEAN BALLARD; Fiscal Year: 2010....
- Optimization of adoptive immunotherapy with autologous CD20-specific T cellsBrian Till; Fiscal Year: 2013....
- The Role of CD5 in B-Cell Development and AutoimmunityChander Raman; Fiscal Year: 2012..The role of CD5 in the development of B-cells has been extensively interrogated, but remains unresolved;the goal of this proposal is to fill this gap in our understanding. ..
- T-cell Therapy for B-lineage Acute Lymphoblastic LeukemiaLaurence J N Cooper; Fiscal Year: 2013..LAY SUMMARY: We will infuse CD19-specific T cells after transplantation to improve survival for patients with acute lymphoblastic leukemia. ..
- Regulation of the VDJ recombinase during genotoxic stressKarla K Rodgers; Fiscal Year: 2013..The ability to enhance such a regulatory process may lead to decreased risks of developing lymphoid malignancies following exposure to radiation and other DNA damaging drugs. ..
- Antigen receptor inputs: linking structural, molecular, and cellular responsesJonathan P Schneck; Fiscal Year: 2012..Understanding the arrangement of T cell antigen receptors that is most likely to trigger T cells, will lead to development of methods to manipulate the T cell surface ..
- Glucose energy metabolism in the growth and survival of B lymphocytesTHOMAS CRANE CHILES; Fiscal Year: 2010..abstract_text> ..
- Role of T Cell Mediated Immunity In Emotion And Stress ResponsivenessLeonardo H Tonelli; Fiscal Year: 2012..This may advance the understanding of mind-body interaction and lead to the development of new strategies of interventions to improve the treatment of mental disorders in chronically ill patients. ..
- Regulation of Tumor Associated Macrophages by TGF-betaVenkateshwar G Keshamouni; Fiscal Year: 2012..through cross-talk between TGF-[unreadable] signaling intermediates and the components of both cytokine and antigen receptors including Toll-like receptors...
- Long-Range Genetic and Epigenetic Control of Igh Gene AssemblyEugene M Oltz; Fiscal Year: 2010..We propose studies to address how precursor B cells control long-range changes in the spatial organization of the immunoglobulin heavy chain locus to ensure its proper assembly and pursuant generation of an adaptive immune system. ..
- Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recepHao Wu; Fiscal Year: 2013..These translocations likely activate NF-kB through MALT1 and Bcl10 overexpression. Collectively, these studies suggest that the CBM complex is an attractive therapeutic target neoplastic disorders of the lymphocytes. ..
- Functional role of RAG2 H3K4me3 interaction in V(D)J recombinationMarjorie A Oettinger; Fiscal Year: 2013..Our goal is to understand the normal steps in development and how errors in the process lead to immune deficiency syndromes and lymphoid tumors, with the hope of preventing or treating such diseases. ..
- Role of Non-Core RAG1 in DSB Repair, Cell Survival, and Cell Cycle ProgressionJulie Horowitz; Fiscal Year: 2013..consist of "core" endonuclease regions, and "non-core" regions required for normal assembly of lymphocyte antigen receptors and normal early lymphocyte development...
- Recombinant Antibodies from the Sea LampreyZEEV contact PANCER; Fiscal Year: 2010..actually yielded specificities towards different types of targets, possibly because none of them are natural antigen receptors. Indeed, the only known natural non-Ig antigen receptors are the variable lymphocyte receptors (VLRs) of ..
- Toll-like receptor signaling in the generation of B1b cell memoryKishore R Alugupalli; Fiscal Year: 2012..cell-independent antigens such as bacterial polysaccharides are generated primarily by cross-linking B cell antigen receptors (BCR)...
- Accessibility Control of Antigen Receptor Gene AssemblyEugene M Oltz; Fiscal Year: 2013DESCRIPTION (provided by applicant): The diverse repertoire of antigen receptors required for mammalian immunity is generated in precursor lymphocytes by V(D)J recombination, which fuses random combinations of immunoglobulin (Ig) or T ..
- Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B CellsElizabeth J Shpall; Fiscal Year: 2013....
- IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHYShahriar Yaghoubi; Fiscal Year: 2013..These studies will establish principles and practices for translating PET-based imaging of CAR+ T cells and provide the first human imaging data on the biodistribution of genetically modified T cells. ..
- MOLECULAR AND CELLULAR REGULATION OF TOLERANCEYongwon Choi; Fiscal Year: 2010..T cell immune responses are governed by multiple factors expressed on the cell surface, including antigen receptors, costimulatory proteins, and inhibitory molecules...
- LOCALIZED REVISION OF EPIGENETIC LANDSCAPES INDUCED BY DNA DOUBLE-STRAND BREAKSBarry P Sleckman; Fiscal Year: 2012..We now propose to identify histone modifications that function as intermediates to coordinate the normal repair of DNA-DSBs in mammalian cells. ..
- Structural Immunology of CD1 and CD1-TCR ComplexesDirk M Zajonc; Fiscal Year: 2013..Ultimately we propose to determine the three-dimensional structure of CD1 antigen receptors in complex with different lipids and cognate T cell receptors (TCR's) by x-ray crystallography...
- Mechanism and regulation of DNA end processing in V(D)J recombination and repairJoAnn M Sekiguchi; Fiscal Year: 2013..The vast diversity amongst the antigen receptors genes is generated through V(D)J recombination, a process in which individual V, D, and J gene segments are ..
- Imaging and Function of the Immunological SynapseDavid C Parker; Fiscal Year: 2012....
- Towards a Mouse Model of Classical Hodgkin's Disease and PTLDFREDERICK WAYNE ALT; Fiscal Year: 2013....
- Role of Darc-Chemokine Interaction in the Trafficking of Osteoclast PrecursorsBouchra Edderkaoui; Fiscal Year: 2012....
- Role of HDAC7 in T-cell DevelopmentERIC M VERDIN; Fiscal Year: 2010..abstract_text> ..
- Engineered tumor-specific T cells Resist Hypoxic-Tumor Immunosuppressive Attacks.Patricia Yotnda; Fiscal Year: 2013..3) Such protected T cells can be redirected to additional tumor targets by forced expression of chimeric antigen receptors, reducing tumor escape by antigen loss and broadening the applicability of the engineered cells to a ..
- GUCY2C targeted adoptive T cell therapy to treat metastatic colorectal cancerMichael S Magee; Fiscal Year: 2013..genetically engineered T cells targeted to the tumor antigen guanylyl cyclase C (GUCY2C) by chimeric antigen receptors. GUCY2C is the index example of a class of proteins termed cancer mucosa antigens, expressed selectively in ..
- Functional role of RAG2 H3K4me3 interaction in V(D)J recombinationMarjorie Oettinger; Fiscal Year: 2009..abstract_text> ..
- A TRANSCRIPTION FACTOR WITHIN LIPID RAFTS MODULATES B CELL SIGNALING VIA THE BCRPhilip W Tucker; Fiscal Year: 2010..Understanding how lipid rafts-localized Bright modulates immune responses will impact on our understanding of immunological tolerance, the immune mechanism that prevents the immune system from reacting against self;i.e., autoimmunity. ..
- The adoptive transfer of gene-modified T cells as a cell therapy for lymphomaMARCO L DAVILA; Fiscal Year: 2012..the aims of this proposal, which are dedicated to investigating T cells genetically modified with chimeric antigen receptors (CARs) to target them to tumors...
- Pre-BCR Function Selecting Novel B Cell Receptors in Chronic Lymphocytic LeukemiaKyoko Hayakawa; Fiscal Year: 2010....
- T Cell Modulation by NKG2DThomas Spies; Fiscal Year: 2013..Conversely, enhancing this mechanism in autoimmune disease patients may lower disease activity. The results of our studies may thus lead to development of new therapies. ..
- Gene-engineered adoptive T cell immunotherapy of GBMLaura A Johnson; Fiscal Year: 2012..Genes encoding highly avid T cell receptors (TCR) or chimeric antigen receptors (CAR), which combine highly avid antibody variable regions with T cell signaling molecules, induce T cell ..
- Molecular Regulation of VH Gene Replacement in Human Immature B CellsZhixin Zhang; Fiscal Year: 2012..Understanding the molecular regulation of VH replacement will have important clinical implications, because the frequencies of VH replacement products are significantly elevated in autoimmune diseases and anti-viral responses. ..
- The role of XLF in hematopoietic stem cell maintenance and functionShan Zha; Fiscal Year: 2013..The completion of this proposal will establish a link between HSC and primary immunodeficiency that will have general implication in other genomic instability syndromes. ..
- Immunoglobulin Constant Region Switch and Hypermutation in the Nurse SharkEllen Hsu; Fiscal Year: 2012The adaptive immune system is founded on lymphocytes expressing a vast array of antigen receptors that provide specific recognition in responding to pathogen...
- Regulation of CD45 alternative splicing by HNRPLLAnjana Rao; Fiscal Year: 2013..expressed in haematopoietic cells, is an essential modulator of signal transduction through the T and B cell antigen receptors (TCR, BCR)...
- Spatiotemporal control of recombination by the RAG proteins and ATMJANE AMANDA SKOK; Fiscal Year: 2010..We propose to further these studies to understand precisely how these factors achieve these unexpected effects. ..
- Signaling in Thymocyte SelectionGerald R Crabtree; Fiscal Year: 2010..O -'' :6O a"0-5)'' Q.. C^' ::9 4-- >,O E-- o-0 >-O c(6 fl.. 0)0-0_0 .- ((D 1/. o0' :t- can --0 a)- 4)a) 0-Q iii= L"- -P) .-.. (II o( 'nom 0-a ..
- Long-Range Genetic and Epigenetic Control of Tcrb Gene AssemblyEugene M Oltz; Fiscal Year: 2010..We propose studies to address how precursor T lymphocytes control long-range changes in the spatial organization of T cell receptor beta loci to ensure their proper assembly and pursuant generation of a normal adaptive immune system. ..
- Anti-viral and antileukemic T-cell therapy as prophylaxis after HSCTHelen E Heslop; Fiscal Year: 2013..abstract_text> ..
- BTK SIGNALING IN B CELL SURVIVAL BY BAFF-RWasif N Khan; Fiscal Year: 2011..The proposed research will illuminate novel mechanisms by which Btk regulates B cell survival critical for normal B cell survival in the healthy immune system as well as B cell autoimmune and immunodeficiency diseases. ..
- Role of the BCR in B Cell Chronic Lymphocytic LeukemiaDiane F Jelinek; Fiscal Year: 2013..Through these studies, we aim to add novel insight into the etiology of this disease and are optimistic that this information can be used to devise timely novel therapeutic interventions. ..
- Role of ABH1's AP endonuclease activity in immunoglobulin gene diversificationTINA A MUELLER; Fiscal Year: 2010..normal environments requires a highly adaptive immune system to generate an immense repertoire of distinct antigen receptors. In particular, activation-induced deaminase (AID) and uracil DNA N-glycosylase (Ung) create abasic sites in ..
- Regulation of the hematopoietic-cell transmembrane phosphatases CD45 and CD148Tanya S Freedman; Fiscal Year: 2010..Understanding the regulation of these signaling proteins will help us better understand the balance of signals necessary for maintaining appropriate growth patterns and sensitivity in immune cells ..
- Molecular Mechanisms of IL-4 and IL-13 SignalingAchsah D Keegan; Fiscal Year: 2010..Our studies will provide a greater understanding of their mechanism of action and contribution to allergic inflammation. This new knowledge could help to develop better approaches to treat allergy and asthma. ..
- ATM FUNCTION DURING V(D)J RECOMBINATIONBarry P Sleckman; Fiscal Year: 2013..Furthermore, we will elucidate the mechanisms that lead to the frequent aberrant resolution of DNA breaks as chromosomal translocations in ATM-deficient cells. ..
- Chemokine-related acute lung injury pathogenesis in African-American patientsKirsten Neudoerffer Kangelaris; Fiscal Year: 2013..This research will form the basis for an R01-level application to study the association between chemokine-related genomic and protein markers and acute lung injury susceptibility and outcomes in African-American patients. ..
- An Advanced Model to Analyze CD4T Cel Reactions to Antibody and BCR V RegionsLawrence J Wysocki; Fiscal Year: 2012..mouse for genetic analyses of T cell reactions to V region peptides derived from antibodies and B cell antigen receptors (BCR). CD4 T cells make a living by interacting with B cells that present antigenic peptides in MHC II...
- Regulation of cyclin D3 in B lymphocyte developmentMarcus R Clark; Fiscal Year: 2013..These studies will lead to a greater understanding of both the generation of the immune system of those processes that lead to leukemia. ..
- Strategies to enhance immune reconstitution after bone marrow transplantMarcel R m van den Brink; Fiscal Year: 2013..We also plan to engineer an artificial hematopoietic niche for T cell development that can be implanted to enhance T cell development. ..
- Use of Genetically Engineered T cells Targeting Tumor Stroma to Treat Lung CancerSTEVEN MARK ALBELDA; Fiscal Year: 2013..If our strategy proves effective, this project will likely have additional significace beyond lung cancer, since FAP could be targeted in many tumors. ..
- THE V(D)J RECOMBINATION REACTION AND ITS IMPACT ON LYMPHOCYTE DEVELOPMENTBarry P Sleckman; Fiscal Year: 2013....
- Enhancing T Cell Therapy of CancerCliona M Rooney; Fiscal Year: 2013..This series of iterative laboratory and linked clinical studies is expected to yield strategies with the potential to increase cure rates and reduce treatment-related toxicity in patients with a spectrum of resistant solid tumors. ..
- Targeting Daxx-mediated complex for autoimmune diseasesJianke Zhang; Fiscal Year: 2013..Successful completion of these specific aims will provide new insight into the mechanisms of the action by Daxx and lead to better design of measures for prevention and treatment of autoimmune and related diseases. ..
- Il-7 receptor signaling in lymphopoiesisMotonari Kondo; Fiscal Year: 2010..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor, which drive specific steps in lymphocyte development, and to determine the genes involved in this process. ..
- Functions of Bcl10 in LymphocytesRenren Wen; Fiscal Year: 2009..abstract_text> ..
- The Role of ATM in Suppression of LymphomasShan Zha; Fiscal Year: 2013....
- The role of IL-7 in guiding developing B cells through the pre-B cell check-pointKristen Johnson; Fiscal Year: 2010..Ultimately, this work will lead to the generation of new therapeutic targets for the treatment of B cell ALL. ..
- Strategies to improve the adoptive transfer of T cellsStanley R Riddell; Fiscal Year: 2013..The results of these studies are directly relevant for treatment of patients with cancer by adoptive T cell therapy. ..
- Molecular mechanism of immune evasion by Yersinia pestisTomas Mustelin; Fiscal Year: 2003..This information, together with a specific YopH inhibitor that works in the same T cell activation model, will represent valuable progress towards the goal of designing a drug to combat plague mortality. ..
- Analysis of Human B Cell Tolerance in Humanized MiceRoberta Pelanda; Fiscal Year: 2009..These novel systems will also be amenable for testing novel potential therapeutics on patient cells. ..
- IL-1 RECEPTORS AND CUTANEOUS DISEASEThomas Kupper; Fiscal Year: 2003..to host defense strategies first employed by primitive multicellular organisms prior to the evolution of antigen receptors on B and T cells (acquired immunity) in vertebrates...
- Targeting the B Cell Receptor Signaling Network in LymphomaJonathan Irish; Fiscal Year: 2009..This award would significantly advance my long term career goal of using biological and computational tools to create personalized, effective therapies for human cancer. ..
- Targeted antigen receptor treatment of cancerDavid Scheinberg; Fiscal Year: 2009..proposal continues this tradition through targeting tissue-specific antigens for cancer therapy using antigen receptors. The rationale is based on the remarkable specificity of the antigen receptors on T cells and B cells...
- MEMBRANES AND SIGNAL TRANSDUCTIONBARTHOLOMEW SEFTON; Fiscal Year: 2001....
- MOLECULAR CONTROL OF ANTIGEN RECEPTOR GENE ASSEMBLYEugene Oltz; Fiscal Year: 2000..employ a complex series of recombination events (V(D)J recombination) to assemble the enormous diversity of antigen receptors required to mount an effective immune response...
- Universal MUC1 Targeted ImmunotherapyRimas Orentas; Fiscal Year: 2009..cells with significant anti-tumor efficacy can be created by developing improved "third generation" chimeric antigen receptors (CAR) that will target and specifically kill MUC1+ cancers...
- CD45 REGULATION OF T CELL TYROSINE KINASESChristopher Burns; Fiscal Year: 2000..Furthermore, our results may suggest specific strategies to interrupt aberrant immune responses at a very proximal site, potentially through specific targeting of these PTKs or CD45 itself. ..