antigen receptors

Summary

Summary: Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.

Top Publications

  1. ncbi The evolution of vertebrate antigen receptors: a phylogenetic approach
    M H Richards
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada
    Mol Biol Evol 17:146-55. 2000
  2. ncbi The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin
    L M Schnapp
    Department of Medicine, University of California, San Francisco 94143, USA
    J Biol Chem 270:23196-202. 1995
  3. ncbi Crystal structure of a shark single-domain antibody V region in complex with lysozyme
    Robyn L Stanfield
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 305:1770-3. 2004
  4. ncbi Rapid isolation of IgNAR variable single-domain antibody fragments from a shark synthetic library
    Cui Ying Shao
    Department of Molecular and Cell Biology, Foresterhill, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Mol Immunol 44:656-65. 2007
  5. ncbi Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development
    Marilyn Diaz
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunogenetics 54:501-12. 2002
  6. ncbi A naturally occurring NAR variable domain binds the Kgp protease from Porphyromonas gingivalis
    Stewart D Nuttall
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, 3052, Parkville, Vic, Australia
    FEBS Lett 516:80-6. 2002
  7. ncbi Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe
    P J Fink
    University of Washington, Dept of Immunology, Seattle, WA 98195, USA
    Immunol Today 21:561-6. 2000
  8. ncbi Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptors
    Takashi Suzuki
    Department of Biosystems Science, School of Advanced Sciences, Graduate University for Advanced Studies SOKENDAI, Hayama, Japan
    J Immunol 174:2885-91. 2005
  9. pmc The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C
    B Varnum-Finney
    Department of Physiology, University of California, San Francisco 94143 0724, USA
    Neuron 14:1213-22. 1995
  10. doi Organisation and dynamics of antigen receptors: implications for lymphocyte signalling
    Bebhinn Treanor
    London Research Institute, Cancer Research UK, London, UK
    Curr Opin Immunol 22:299-307. 2010

Detail Information

Publications307 found, 100 shown here

  1. ncbi The evolution of vertebrate antigen receptors: a phylogenetic approach
    M H Richards
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada
    Mol Biol Evol 17:146-55. 2000
    ..Analyses of the variable regions are complicated by strong selection on antigen-binding sequences, but imply that direct antigen binding is the ancestral condition...
  2. ncbi The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin
    L M Schnapp
    Department of Medicine, University of California, San Francisco 94143, USA
    J Biol Chem 270:23196-202. 1995
    ....
  3. ncbi Crystal structure of a shark single-domain antibody V region in complex with lysozyme
    Robyn L Stanfield
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 305:1770-3. 2004
    ..Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, ..
  4. ncbi Rapid isolation of IgNAR variable single-domain antibody fragments from a shark synthetic library
    Cui Ying Shao
    Department of Molecular and Cell Biology, Foresterhill, School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Mol Immunol 44:656-65. 2007
    ..The results here demonstrate that a synthetic IgNAR variable domain library based on a single framework scaffold can be used as a route to generate antigen binders quickly, easily and without the need of immunization...
  5. ncbi Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development
    Marilyn Diaz
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunogenetics 54:501-12. 2002
    ....
  6. ncbi A naturally occurring NAR variable domain binds the Kgp protease from Porphyromonas gingivalis
    Stewart D Nuttall
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, 3052, Parkville, Vic, Australia
    FEBS Lett 516:80-6. 2002
    ..Binding localised to the Kgp adhesin domains, however without inhibiting adhesin activity. These naturally occurring proteins indicate an immune response to pathogenic bacteria and suggest that the NAR is a true antibody-like molecule...
  7. ncbi Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe
    P J Fink
    University of Washington, Dept of Immunology, Seattle, WA 98195, USA
    Immunol Today 21:561-6. 2000
    Pamela Fink and Catherine McMahan discuss how B and T cells test for useful antigen receptors and weed out potentially harmful ones, with special attention paid to T-cell receptor revision, a newly described mechanism by which mature T ..
  8. ncbi Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptors
    Takashi Suzuki
    Department of Biosystems Science, School of Advanced Sciences, Graduate University for Advanced Studies SOKENDAI, Hayama, Japan
    J Immunol 174:2885-91. 2005
    ..The extracellular domain of APAR may be descended from a V-type domain postulated to have acquired recombination signal sequences in a jawed vertebrate lineage...
  9. pmc The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C
    B Varnum-Finney
    Department of Physiology, University of California, San Francisco 94143 0724, USA
    Neuron 14:1213-22. 1995
    ..The major domain in tenascin that mediates neurite outgrowth is shown to be localized to fibronectin type III repeats 6-8...
  10. doi Organisation and dynamics of antigen receptors: implications for lymphocyte signalling
    Bebhinn Treanor
    London Research Institute, Cancer Research UK, London, UK
    Curr Opin Immunol 22:299-307. 2010
    ..Here, we discuss recent findings on the regulation of steady-state organisation and diffusion dynamics of immunoreceptors, and how this might impact on our understanding of basal and ligand-dependent signalling...
  11. ncbi Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display
    Helen Dooley
    Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Mol Immunol 40:25-33. 2003
    ..This approach can therefore be considered as an alternative route for the isolation of minimal antigen-binding fragments with favorable characteristics...
  12. ncbi Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop libraries
    S D Nuttall
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Mol Immunol 38:313-26. 2001
    ..Thus, the New Antigen Receptor represents a protein scaffold with possible stability advantages over conventional antibodies when used in in vitro molecular libraries...
  13. ncbi Transducing signals from antigen receptors to nuclear factor kappaB
    Jurgen Ruland
    Advanced Medical Discovery Institute, Ontario Cancer Institute and University of Toronto, Toronto, ON, Canada
    Immunol Rev 193:93-100. 2003
    ..Bcl-10 is known to participate in chromosomal translocations in human mucosa-associated lymphoid tissue lymphomas...
  14. ncbi T cell-specific loss of Pten leads to defects in central and peripheral tolerance
    A Suzuki
    Department of Molecular and Cellular Biology, Osaka University, 565 0871, Osaka, Japan
    Immunity 14:523-34. 2001
    ..Peripheral tolerance to SEB is also impaired in Pten(flox/-) mice. PTEN is thus an important regulator of T cell homeostasis and self-tolerance...
  15. pmc The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2
    V Aidinis
    Howard Hughes Medical Institute, Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biol 19:6532-42. 1999
    ..A transient increase of HMG1,2 concentration in transfected cells increases the production of the final V(D)J recombinants in vivo...
  16. ncbi V(D)J recombination: RAG proteins, repair factors, and regulation
    Martin Gellert
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 0540, USA
    Annu Rev Biochem 71:101-32. 2002
    ..This transposition helps to explain the mechanism of RAG action and supports earlier proposals that V(D)J recombination evolved from an ancient mobile DNA element...
  17. ncbi Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling
    Jesse E Jun
    Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Nat Immunol 4:1057-64. 2003
    Lymphocyte antigen receptors are responsible for inducing the opposite responses of immunity or tolerance. How the correct polarity of antigen receptor signaling is encoded has been an enduring enigma...
  18. pmc HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent
    Aleksei N Kriatchko
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, 2500 California Plaza, Omaha, NE, USA
    BMC Mol Biol 9:32. 2008
    ..Here we test whether this apparent discrepancy is attributed to the choice of divalent metal ion and the concentration of HMGB1 used in the cleavage reaction...
  19. pmc Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?"
    Gianpietro Dotti
    Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital, Houston, TX 77030, USA
    Hum Gene Ther 20:1229-39. 2009
    ..In this review we summarize the concept of CAR-based immunotherapy, describe the steps accomplished, and outline the future progress we need to make if this approach is truly to improve cancer immunotherapy...
  20. ncbi Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase
    Igor B Rogozin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Nat Immunol 8:647-56. 2007
    ..Vertebrate acquired immunity could have therefore originated from lymphocyte receptor diversification by an ancestral AID-like DNA cytosine deaminase...
  21. ncbi Positive versus negative signaling by lymphocyte antigen receptors
    J I Healy
    Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305, USA
    Annu Rev Immunol 16:645-70. 1998
    b>Antigen receptors on lymphocytes play a central role in immune regulation by transmitting signals that positively or negatively regulate lymphocyte survival, migration, growth, and differentiation...
  22. pmc Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
    Cheryl A Doughty
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    Blood 107:4458-65. 2006
    ..Manipulation of these pathways may prove to be useful in the treatment of lymphoproliferative disorders, wherein clonal expansion of B lymphocytes plays a role...
  23. ncbi Binding of HIV-1 to RBCs involves the Duffy antigen receptors for chemokines (DARC)
    A Lachgar
    Laboratoire de Physiologie Cellulaire, Universite P et M Curie, Paris, France
    Biomed Pharmacother 52:436-9. 1998
    ..This finding suggests that RBCs may function as a reservoir for HIV-1 or as a receptor for the entry of HIV-1 into CD4-cell subsets as well as neurons or endothelial cells...
  24. ncbi From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-kappaB
    Jurgen Ruland
    Advanced Medical Discovery Institute, Ontario Cancer Institute and University of Toronto, 620 University Avenue, Toronto, Ont, Canada M5G 2C1
    Semin Immunol 15:177-83. 2003
    ..signal transduction pathways leading to NF-kappaB activation that are triggered by engagement of the antigen receptors of T and B cells...
  25. pmc Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor
    V A Streltsov
    Division of Health Sciences and Nutrition, Commonwealth Scientific and Industrial Research Organization, and Cooperative Research Centre for Diagnostics, 343 Royal Parade, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 101:12444-9. 2004
    The Ig new antigen receptors (IgNARs) are single-domain antibodies found in the serum of sharks. Here, we report 2.2- and 2.8-A structures of the type 2 IgNAR variable domains 12Y-1 and 12Y-2...
  26. ncbi Selection of cholera toxin specific IgNAR single-domain antibodies from a naïve shark library
    Jinny L Liu
    Center for Bio Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC 20375, USA
    Mol Immunol 44:1775-83. 2007
    ..The successful isolation of target specific sdAbs from one of our non-biased NAR libraries, demonstrate their ability to provide binders against an unacquainted antigen of interest...
  27. ncbi Antigen receptor signaling: the Tuscan connection
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    Nat Immunol 8:787-90. 2007
  28. ncbi CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction
    C Kung
    Howard Hughes Medical Institute, Department of Pathology and Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 29:3951-5. 1999
    CD45 is a transmembrane protein tyrosine phosphatase required for signaling through the T-and B-cell antigen receptors. In lymphocytes, CD45 interacts with CD45-associated protein (CD45AP), a 32 000 Mr phosphoprotein, through their ..
  29. pmc Direct measurement of lymphocyte receptor diversity
    Brenda M Ogle
    Transplantation Biology Program, Department of Physiology, Mayo Clinic, Rochester, Minnesota, MN 55905, USA
    Nucleic Acids Res 31:e139. 2003
    ..In addition, this approach could be more broadly applied, for example to measure diversity of viral quasi-species...
  30. ncbi Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70
    Stewart D Nuttall
    CSIRO Health Sciences and Nutrition, Parkville, Victoria, Australia
    Eur J Biochem 270:3543-54. 2003
    ....
  31. ncbi Chromatin modifications as clues to the regulation of antigen receptor assembly
    David Ciccone
    Department of Molecular Biology, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
    Novartis Found Symp 259:146-58; discussion 158-69. 2004
    ..The specific patterns of modification imply that the regulation of V(D)J recombination involves recruitment of specific methyltransferases in a localized manner...
  32. pmc T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segments
    E Kraig
    J Exp Med 158:192-209. 1983
    ..Furthermore, the presence of idiotypic determinants on T lymphocytes does not necessarily imply close structural similarity between T and B cell antigen receptors.
  33. ncbi Genetic dissection of antigen receptor induced-NF-kappaB activation
    Zhi Wei Li
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 3011 West Holly Drive, SRB 22344, Tampa, FL 33612, USA
    Mol Immunol 41:701-14. 2004
    ..This review addresses the cell signaling from antigen receptors as well as Toll-like receptors to NF-kappaB in both innate and adaptive immunity as revealed by the analysis ..
  34. ncbi High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias
    S Hubner
    Children s Cancer Research Institute, St Anna Kinderspital, Vienna, Austria
    Leukemia 18:84-91. 2004
    ....
  35. ncbi Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
    Zeev Pancer
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 430:174-80. 2004
    ..are apparently capable of adaptive immune responses, they have not been found to possess the recombinatorial antigen receptors shared by all jawed vertebrates...
  36. ncbi Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
    L L Lanier
    DNAX Research Institute of Molecular and Cellular Biology, Department of Immunobiology, Palo Alto, California 94304, USA
    Nature 391:703-7. 1998
    ..Phosphorylated DAP12 peptides bind ZAP-70 and Syk protein tyrosine kinases, suggesting that the activation pathway is similar to that of the T- and B-cell antigen receptors.
  37. ncbi Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
    A Tarakhovsky
    Institute for Genetics, University of Cologne, Germany
    Nature 374:467-70. 1995
    Crosslinking of B- or T-cell antigen receptors results in the rapid tyrosine phosphorylation of a number of proteins, including Vav, a protein expressed in cells of the haematopoietic system...
  38. ncbi ATM prevents unattended DNA double strand breaks on site and in generations to come
    Bu Yin
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 6:1837-9. 2007
    ..Collectively, these results have provided complementary mechanistic insights into ATM functions in V(D)J recombination that can account for the lymphoid tumor-prone phenotype associated with A-T...
  39. ncbi Mechanisms of antigen receptor evolution
    Donna D Eason
    Department of Pediatrics, Children s Research Institute, University of South Florida College of Medicine, 830 First Street South, St Petersburg, FL 33701, USA
    Semin Immunol 16:215-26. 2004
    ..Homologs of immunoglobulins (Igs), T cell antigen receptors (TCRs), major histocompatibility complex (MHC) I and II, and the recombination activating genes (RAGs) have ..
  40. ncbi Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone
    Seoyeon Choi
    Children s Cancer Institute Australia for Medical Research, Sydney, Australia
    Blood 110:632-9. 2007
    ..Relapse prediction may be improved with strategies to detect minor potentially resistant subclones early during treatment, hence allowing intensification of therapy...
  41. ncbi Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure
    J Ruland
    Amgen Institute, 620 University Avenue, Toronto, Ontario, Canada M5G 2C1
    Cell 104:33-42. 2001
    ..Thus, Bcl10 functions as a positive regulator of lymphocyte proliferation that specifically connects antigen receptor signaling in B and T cells to NF-kappaB activation...
  42. pmc Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFkappaB activity in vertebrate B-cells
    Ping Liu
    Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK
    FEBS Lett 581:1377-82. 2007
    ..Thus, PKDs have a selective role in DT40 B-cell biology...
  43. ncbi MHC class II signaling in antigen-presenting cells
    Reem Al-Daccak
    Institut Universitaire d Hematologie, IFR105, Hôpital Saint Louis AP HP, 10 rue Claude Vellefaux, 75475 Paris, France
    Curr Opin Immunol 16:108-13. 2004
    ..Recent advances have provided insights into how these molecules might accommodate such regulation...
  44. pmc CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
    K F Byth
    Department of Pathology, Cambridge University, United Kingdom
    J Exp Med 183:1707-18. 1996
    ..We conclude that CD45 is not required at any stage during the generation of mature peripheral B cells, however its loss reveals a previously unrecognized role for CD45 in the regulation of certain subpopulations of B cells...
  45. ncbi Immunology: another manifestation of GOD
    Martin F Flajnik
    Nature 430:157-8. 2004
  46. ncbi Shattuck lecture: Diversity of the immune repertoire and immunoregulation
    Robert S Schwartz
    N Engl J Med 348:1017-26. 2003
  47. ncbi The Vav family: at the crossroads of signaling pathways
    Wojciech Swat
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:259-65. 2005
    ..exchange factors (GEFs) is thought to control a diverse array of signaling pathways emanating from antigen receptors in lymphocytes, although the exact mechanism by which Vav exerts its function is only beginning to emerge...
  48. ncbi Unraveling V(D)J recombination; insights into gene regulation
    David Jung
    Howard Hughes Medical Institute, The Children s Hospital, The CBR Institute for Biomedical Research, Inc, Harvard Medical School, Boston, MA 02115, USA
    Cell 116:299-311. 2004
    ....
  49. doi Antibody responses of variable lymphocyte receptors in the lamprey
    Matthew N Alder
    Office of Fundamental Immunology Research, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA
    Nat Immunol 9:319-27. 2008
    ..Lacking a thymus and the ability to respond to soluble protein antigens, lampreys seem to have evolved a B cell-like system for adaptive humoral responses...
  50. ncbi Homeostatic control of lymphocyte survival: potential origins and implications
    David R Plas
    Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nat Immunol 3:515-21. 2002
    ....
  51. ncbi Pathways for self-tolerance and the treatment of autoimmune diseases
    C C Goodnow
    Australian Cancer Research Foundation, Genetics Laboratory, Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Lancet 357:2115-21. 2001
    ..New experimental therapies aim to mimic tolerogenic antigen signals by chronically stimulating antigen receptors with antigen or antibodies to the receptor, or aim to block costimulatory pathways involving CD40 ligand, B7,..
  52. pmc Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K
    Klaus Okkenhaug
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK, CB2 4AT
    Trends Immunol 28:80-7. 2007
    The activation of antigen receptors triggers two important signalling pathways originating from phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P(2)]...
  53. pmc A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement
    Yun Liu
    Department of Molecular Biology and Genetics, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunity 27:561-71. 2007
    ..Together, these findings are consistent with the interpretation that recognition of hypermethylated histone H3 K4 promotes efficient V(D)J recombination in vivo...
  54. ncbi CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells
    Birgitta Messmer
    Institute for Immunology, University of Heidelberg, Heidelberg, Germany
    J Immunol 176:4646-50. 2006
    ..This demonstrates that 2B4 can stimulate NK cell cytotoxicity and cytokine production by interacting with NK cell expressed CD48 and adds CD48 to the growing number of activating NK cell receptors...
  55. ncbi Immunoglobulins in the eggs of the nurse shark, Ginglymostoma cirratum
    Ashley N Haines
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, 655 W Baltimore Street, Rm 13 009, Baltimore, MD 21202, USA
    Dev Comp Immunol 29:417-30. 2005
    ..Using monoclonal antibodies, we establish the presence of two classes of Igs in nurse shark eggs: 7S IgM and IgNAR. The potential transfer of immunoglobulins from elasmobranch eggs is discussed...
  56. ncbi [Chromatin dynamics in gene rearrangement]
    Yasutoshi Agata
    Tanpakushitsu Kakusan Koso 51:315-25. 2006
  57. ncbi SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations
    Joseph M Volpe
    Computational Biology and Bioinformatics Program, Duke University Medical Center Box 90090 Duke University, Durham, NC 27708 0090, USA
    Bioinformatics 22:438-44. 2006
    The antigen receptors of adaptive immunity-T-cell receptors and immunoglobulins-are encoded by genes assembled stochastically from combinatorial libraries of gene segments...
  58. ncbi CD38 is expressed on human mature monocyte-derived dendritic cells and is functionally involved in CD83 expression and IL-12 induction
    Giorgio Fedele
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 34:1342-50. 2004
    ..Activation via agonistic anti-CD38 mAb induces up-regulation of CD83 expression and IL-12 secretion, whereas disruption of CD38/CD31 interaction inhibits CD83 expression, IL-12 secretion and MDDC-induced allogeneic T cell proliferation...
  59. ncbi B cell antigen receptor signaling enhances IFN-gamma-induced Stat1 target gene expression through calcium mobilization and activation of multiple serine kinase pathways
    Weifeng Xu
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Interferon Cytokine Res 25:113-24. 2005
    ..These studies demonstrate that a wide variety of noncytokine signaling pathways can modulate cytokine signaling through modulation of Stat1 serine phosphorylation...
  60. pmc Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling
    Whitney E Purtha
    Departments of Medicine, Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St Louis, MO 63110, USA
    J Virol 82:10964-74. 2008
    ....
  61. ncbi Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65
    D Yablonski
    Department of Pharmacology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Bat Galim, Haifa 31096, Israel
    Adv Immunol 79:93-128. 2001
    ....
  62. ncbi Retargeting of natural killer-cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction
    Christoph Uherek
    Chemotherapeutisches Forschungsinstitut Georg Speyer Haus, Frankfurt am Main, Germany
    Blood 100:1265-73. 2002
    ..These results demonstrate that efficient retargeting of NK-92 cytotoxicity can be achieved and might allow the generation of potent cell-based therapeutics for the treatment of ErbB2-expressing malignancies...
  63. ncbi The MAGUK family protein CARD11 is essential for lymphocyte activation
    Hiromitsu Hara
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Immunity 18:763-75. 2003
    ..Our results show that the same family of molecules are critical regulators of neuronal synapses and immune receptor signaling...
  64. ncbi Basic and tumor immunology: a review
    Roger W Melvold
    Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202 9037, USA
    Surg Oncol Clin N Am 16:711-35, vii. 2007
    ..We are also learning about how it communicates with the environment and how its various components interact within the body. With this information, we are learning how to manipulate it to our greater benefit...
  65. doi Finally, MALT1 is a protease!
    Linda M McAllister-Lucas
    Nat Immunol 9:231-3. 2008
  66. ncbi Phosphorylation of CARMA1: the link(er) to NF-kappaB activation
    Daniel Rueda
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 23:551-3. 2005
    ..Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-kappaB...
  67. ncbi Affinity-dependent alterations of mouse B cell development by noninherited maternal antigen
    Cecile Vernochet
    Laboratory of Immune Regulations and Development, J Monod Institute, Paris, France
    Biol Reprod 72:460-9. 2005
    ..Thus, we show that fetal and neonatal B cell development is affected by maternal cells bearing antigens noninherited by the fetus and that this phenomenon is highly dependent on the affinity of the B cell receptor for the NIMA...
  68. ncbi Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3
    R R Rivera
    Department of Biology, 0366 University of California, San Diego, La Jolla 92093, USA
    Immunity 12:17-26. 2000
    ..Finally, we show that E2A and Id3 interact genetically to regulate thymocyte development. These observations identify the HLH inhibitory protein Id3 as an essential component required for proper thymocyte maturation...
  69. ncbi Detection of receptor trimers on the cell surface by flow cytometric fluorescence energy homotransfer measurements
    Laszlo Bene
    Department of Biophysics and Cell Biology, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Hungary
    Biochim Biophys Acta 1744:176-98. 2005
    ....
  70. ncbi Bridging B cell and T cell recognition of antigen
    Hidde L Ploegh
    J Immunol 179:7193. 2007
  71. ncbi [Studies on the relationship between unexplained recurrent spontaneous abortion and immunotolerance at the maternal-fetal interface]
    Qi De Lin
    Zhonghua Fu Chan Ke Za Zhi 41:145-7. 2006
  72. pmc Effect of CpG methylation on RAG1/RAG2 reactivity: implications of direct and indirect mechanisms for controlling V(D)J cleavage
    Hiroshi Nakase
    Institute for Genome Research, University of Tokushima, Japan
    EMBO Rep 4:774-80. 2003
    ....
  73. ncbi A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes
    Barbara L Rellahan
    Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, NIH, Bethesda, MD 20892, USA
    Exp Cell Res 289:184-94. 2003
    ..The interaction of c-Cbl with PLCgamma1 may negatively effect events required for PLCgamma1 activation...
  74. pmc Detection of monoclonal immunoglobulin heavy chain gene rearrangement (FR3) in Thai malignant lymphoma by High Resolution Melting curve analysis
    Tanawan Kummalue
    Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Bangkok 10700, Thailand
    Diagn Pathol 5:31. 2010
    ..In conclusion, the detection IgH gene rearrangement by HRM in the LightCycler System showed potential for distinguishing monoclonality from polyclonality in B-cell non-Hodgkin lymphoma...
  75. ncbi Extracellular purines and their receptors in immunoregulation. Review of recent advances
    M V Sitkovsky
    Laboratory of Immunology, NIAID, NIH, Bethesda, MD 20892, USA
    Nihon Ika Daigaku Zasshi 65:351-7. 1998
    ..g. affecting TCR-multimolecular complex formation and antigen binding affinity. It is suggested that TCR ectodomain phosphorylation could serve as a potential mechanism for regulation of TCR-mediated T-lymphocytes response...
  76. ncbi AKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domain
    P Rieske
    Department of Biochemistry, MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 276:8460-8. 2001
    ..Consistent with these studies, ligation of antigen receptors in A20 B cells mimics AKT activation of PU.1. Taken together, these results provide evidence that PU...
  77. ncbi Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulation
    Daniel J Bolland
    Laboratory of Chromatin and Gene Expression, Babraham Institute, Babraham Research Campus, Cambridge, UK
    Adv Exp Med Biol 650:59-72. 2009
    ....
  78. ncbi [Effects of immunosuppressive treatment in prevention of calcification in aortic valved homograft: experiment with rats]
    Xing jun Gong
    Department of Cardiac Surgery, Qilu Hospital, Shandong University, Jinan 250012, China
    Zhonghua Yi Xue Za Zhi 87:2132-5. 2007
    ..To investigate the effects of immunosuppressive treatment in prevention of calcification in aortic valved homograft (AVH)...
  79. ncbi Selected problems of malaria blood stage immunity
    P Perlmann
    Department of Immunology, Stockholm University, Sweden
    Tokai J Exp Clin Med 23:55-62. 1998
    ..falciparum in human malaria...
  80. ncbi Co-ordinate action of bacterial adhesins and human carcinoembryonic antigen receptors in enhanced cellular invasion by capsulate serum resistant Neisseria meningitidis
    Helen A Rowe
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Cell Microbiol 9:154-68. 2007
    ....
  81. ncbi Southeast Asian ovalocytosis is associated with increased expression of Duffy antigen receptor for chemokines (DARC)
    I J Woolley
    Department of Infectious Diseases, Monash Medical Centre and Monash University, Clayton, Victoria, Australia
    Immunohematology 25:63-6. 2009
    ..61 +/- 19.12 for SAO heterozygotes and 16.47 +/- 3.81 for controls. SAO is associated with increased and not decreased Fy6 expression so that susceptibility to P. vivax infection is unlikely to be affected...
  82. pmc Major histocompatibility complex independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptor
    C R Hewitt
    Imperial Cancer Research Fund, London, UK
    J Exp Med 175:1493-9. 1992
    ..We conclude that SEB interacts directly with the TCR in the absence of cointeraction with MHC class II molecules, and that this interaction may induce anergy in HA1.7...
  83. ncbi Preclinical results of sirolimus treatment in transplant models
    S M Stepkowski
    Division of Immunology and Organ Transplantation, Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Transplant Proc 35:219S-226S. 2003
    ..Furthermore, CsA potentiated SRL-mediated toxicities, namely myelosuppression and increased cholesterol. In conclusion, SRL therapy is synergistic with CsA but both drug levels should be carefully monitored to avoid toxic effects...
  84. ncbi The related molecular chaperones calnexin and calreticulin differentially associate with nascent T cell antigen receptor proteins within the endoplasmic reticulum
    J E van Leeuwen
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Biol Chem 271:25345-9. 1996
    ..These studies identify calreticulin as a molecular chaperone for nascent clonotypic TCRalpha and -beta proteins and demonstrate that calreticulin and calnexin differentially associate with newly synthesized TCR proteins within the ER...
  85. ncbi Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex
    S Vasile
    Department of Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
    Mol Immunol 31:419-27. 1994
    ..In addition, we found that there is a strong amino acid sequence homology between the microtubule-binding domains of certain human microtubule-associated proteins and an intracellular segment of the human mb-1 protein...
  86. ncbi Temporal ordering of caspase activation and substrate cleavage during antigen receptor-triggered apoptosis in Ramos-Burkitt lymphoma B cells
    Sungkwan An
    Department of Biochemistry, University of Oxford, UK
    Int J Oncol 23:257-68. 2003
    ..An understanding of the role played by caspases in the execution of apoptosis may provide insight into the pathogenesis of these disease states and thereby provide targets for novel therapeutic strategy...
  87. pmc Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines
    S Lew
    Department of Microbiology, Molecular and Cellular Biology Program, Arizona State University, Tempe, Arizona 85287 2701, USA
    Mol Cell Biol 20:7170-7. 2000
    ..These data suggest that an inability of scid cells to promptly resolve their recombination ends exposes the ends to a random joining process, which can conceivably lead to chromosomal translocations...
  88. pmc Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells
    Anne E Lieberman
    Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA
    BMC Immunol 10:37. 2009
    ..These results are inconsistent with a model of cRS cleavage during autoreactivity-induced VH gene replacement...
  89. pmc Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis
    Christina L Addison
    Departments of Medicine, Pathology, and Pediatrics, Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles CA, 90024 1922 USA
    BMC Cancer 4:28. 2004
    ....
  90. pmc Differential role of reactive oxygen species in the activation of mitogen-activated protein kinases and Akt by key receptors on B-lymphocytes: CD40, the B cell antigen receptor, and CXCR4
    Rosaline L Lee
    Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Cell Commun Signal 1:33-43. 2007
    ..We focused on activation of ERK, JNK, p38, and Akt, kinases that regulate multiple processes including cell survival, proliferation, and migration...
  91. doi The structural basis for autonomous dimerization of the pre-T-cell antigen receptor
    Siew Siew Pang
    The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Nature 467:844-8. 2010
    ..This unusual dual-chaperone-like sensing function of pre-Tα represents a unique mechanism in nature whereby developmental quality control regulates the expression and signalling of an integral membrane receptor complex...
  92. pmc Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes
    J Zhang
    Department of Medicine, University of Toronto, Ontario, Canada M5G 1X5
    J Exp Med 190:1329-42. 1999
    ..The data also reveal a role for WASp in modulating endocytosis and phagocytosis and, accordingly, suggest that the immune deficit conferred by WASp deficiency reflects the disruption of a broad range of cellular behaviors...
  93. ncbi Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest
    M C Horne
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, USA
    J Biol Chem 272:12650-61. 1997
    ..These results suggest that in murine B cells responding to growth inhibitory stimuli cyclin G2 may be a key negative regulator of cell cycle progression...
  94. ncbi Immunoglobulin superfamily receptors in protochordates: before RAG time
    Louis Du Pasquier
    Institute of Zoology, University of Basel, Basel, Switzerland
    Immunol Rev 198:233-48. 2004
    ..They use the domains typical of vertebrate antigen receptors and class I and II: the V, and C1-like domains...
  95. ncbi B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms
    Q Vos
    Department of Medicine, Uniformed Services, University of the Health Sciences, Bethesda, Maryland, USA
    Immunol Rev 176:154-70. 2000
    ..of pathogens in an organized, highly repetitive form can activate specific B cells by cross-linking of antigen receptors in a multivalent fashion...
  96. ncbi A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function
    K Reif
    Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Curr Biol 7:285-93. 1997
    ..In this study, we investigated the importance of PI 3-kinase in TCR-directed T-cell activation using activated or inhibitory versions of PI 3-kinase...
  97. ncbi Activation of Valpha24NKT cells in malignant pleural effusion in patients with lung cancer
    Tetsuo Shimizu
    Department of Respiratory Medicine, Nihon University School of Medicine, 173 8610 Tokyo, Japan
    Oncol Rep 22:581-6. 2009
    Valpha24NKT cells are lymphocytes expressing both T-cell antigen receptors and NK-cell antigen receptors on their cell surface and are involved in tumor immunity...
  98. doi Association between Duffy antigen receptor for chemokines expression and levels of inflammation markers in sickle cell anemia patients
    Danitza Nebor
    UMR S_763 Inserm Université des Antilles et de la Guyane, Hôpital RICOU, CHU de Pointe a Pitre, 97159 Pointe a Pitre, Guadeloupe
    Clin Immunol 136:116-22. 2010
    ..46+/-1.22 vs 1.47+/-0.5 pg/mL, p=0.0202) and RANTES (27.8+/-4.3 vs 18.1+/-2.3 ng/mL, p=0.04) than Duffy-negative patients. No association was detected between RBC expression of DARC and the studied complications...
  99. pmc ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
    N Isakov
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Exp Med 181:375-80. 1995
    ..The cooperativity ensures higher affinity for the doubly phosphorylated ligand. Affinity differences of as much as 30-fold indicates a significant specificity of interaction of ZAP-70 SH2 domains for different phospho-TAMs...
  100. ncbi A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1-induced lethal shock in V beta 8.2 T-cell receptor transgenic mice
    C M Cullen
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45267, USA
    Pathobiology 63:293-304. 1995
    ..Although induction of toxic shock is clearly associated with T-cell proliferation, defects in fas antigen receptor or ligand may also contribute substantively to superantigen-mediated lethal shock by still undefined mechanisms...
  101. pmc CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1
    J J Perez-Villar
    Immunology and Inflammation Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Mol Cell Biol 19:2903-12. 1999
    ..These results suggest a critical role of the CD5 ITIM-like motif, which by binding to SHP-1 mediates the down-regulatory activity of this receptor...

Research Grants71

  1. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..Lessons learnt from understanding the role of ezrin in B cell function can be applied towards therapeutic design for B cell-dependent human diseases. ..
  2. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ....
  3. Optimization of adoptive immunotherapy with autologous CD20-specific T cells
    Brian Till; Fiscal Year: 2013
    ....
  4. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2012
    ..The role of CD5 in the development of B-cells has been extensively interrogated, but remains unresolved;the goal of this proposal is to fill this gap in our understanding. ..
  5. T-cell Therapy for B-lineage Acute Lymphoblastic Leukemia
    Laurence J N Cooper; Fiscal Year: 2013
    ..LAY SUMMARY: We will infuse CD19-specific T cells after transplantation to improve survival for patients with acute lymphoblastic leukemia. ..
  6. Regulation of the VDJ recombinase during genotoxic stress
    Karla K Rodgers; Fiscal Year: 2013
    ..The ability to enhance such a regulatory process may lead to decreased risks of developing lymphoid malignancies following exposure to radiation and other DNA damaging drugs. ..
  7. Antigen receptor inputs: linking structural, molecular, and cellular responses
    Jonathan P Schneck; Fiscal Year: 2012
    ..Understanding the arrangement of T cell antigen receptors that is most likely to trigger T cells, will lead to development of methods to manipulate the T cell surface ..
  8. Glucose energy metabolism in the growth and survival of B lymphocytes
    THOMAS CRANE CHILES; Fiscal Year: 2010
    ..abstract_text> ..
  9. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..This may advance the understanding of mind-body interaction and lead to the development of new strategies of interventions to improve the treatment of mental disorders in chronically ill patients. ..
  10. Regulation of Tumor Associated Macrophages by TGF-beta
    Venkateshwar G Keshamouni; Fiscal Year: 2012
    ..through cross-talk between TGF-[unreadable] signaling intermediates and the components of both cytokine and antigen receptors including Toll-like receptors...
  11. Long-Range Genetic and Epigenetic Control of Igh Gene Assembly
    Eugene M Oltz; Fiscal Year: 2010
    ..We propose studies to address how precursor B cells control long-range changes in the spatial organization of the immunoglobulin heavy chain locus to ensure its proper assembly and pursuant generation of an adaptive immune system. ..
  12. Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep
    Hao Wu; Fiscal Year: 2013
    ..These translocations likely activate NF-kB through MALT1 and Bcl10 overexpression. Collectively, these studies suggest that the CBM complex is an attractive therapeutic target neoplastic disorders of the lymphocytes. ..
  13. Functional role of RAG2 H3K4me3 interaction in V(D)J recombination
    Marjorie A Oettinger; Fiscal Year: 2013
    ..Our goal is to understand the normal steps in development and how errors in the process lead to immune deficiency syndromes and lymphoid tumors, with the hope of preventing or treating such diseases. ..
  14. Role of Non-Core RAG1 in DSB Repair, Cell Survival, and Cell Cycle Progression
    Julie Horowitz; Fiscal Year: 2013
    ..consist of "core" endonuclease regions, and "non-core" regions required for normal assembly of lymphocyte antigen receptors and normal early lymphocyte development...
  15. Recombinant Antibodies from the Sea Lamprey
    ZEEV contact PANCER; Fiscal Year: 2010
    ..actually yielded specificities towards different types of targets, possibly because none of them are natural antigen receptors. Indeed, the only known natural non-Ig antigen receptors are the variable lymphocyte receptors (VLRs) of ..
  16. Toll-like receptor signaling in the generation of B1b cell memory
    Kishore R Alugupalli; Fiscal Year: 2012
    ..cell-independent antigens such as bacterial polysaccharides are generated primarily by cross-linking B cell antigen receptors (BCR)...
  17. Accessibility Control of Antigen Receptor Gene Assembly
    Eugene M Oltz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The diverse repertoire of antigen receptors required for mammalian immunity is generated in precursor lymphocytes by V(D)J recombination, which fuses random combinations of immunoglobulin (Ig) or T ..
  18. Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B Cells
    Elizabeth J Shpall; Fiscal Year: 2013
    ....
  19. IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHY
    Shahriar Yaghoubi; Fiscal Year: 2013
    ..These studies will establish principles and practices for translating PET-based imaging of CAR+ T cells and provide the first human imaging data on the biodistribution of genetically modified T cells. ..
  20. MOLECULAR AND CELLULAR REGULATION OF TOLERANCE
    Yongwon Choi; Fiscal Year: 2010
    ..T cell immune responses are governed by multiple factors expressed on the cell surface, including antigen receptors, costimulatory proteins, and inhibitory molecules...
  21. LOCALIZED REVISION OF EPIGENETIC LANDSCAPES INDUCED BY DNA DOUBLE-STRAND BREAKS
    Barry P Sleckman; Fiscal Year: 2012
    ..We now propose to identify histone modifications that function as intermediates to coordinate the normal repair of DNA-DSBs in mammalian cells. ..
  22. Structural Immunology of CD1 and CD1-TCR Complexes
    Dirk M Zajonc; Fiscal Year: 2013
    ..Ultimately we propose to determine the three-dimensional structure of CD1 antigen receptors in complex with different lipids and cognate T cell receptors (TCR's) by x-ray crystallography...
  23. Mechanism and regulation of DNA end processing in V(D)J recombination and repair
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..The vast diversity amongst the antigen receptors genes is generated through V(D)J recombination, a process in which individual V, D, and J gene segments are ..
  24. Imaging and Function of the Immunological Synapse
    David C Parker; Fiscal Year: 2012
    ....
  25. Towards a Mouse Model of Classical Hodgkin's Disease and PTLD
    FREDERICK WAYNE ALT; Fiscal Year: 2013
    ....
  26. Role of Darc-Chemokine Interaction in the Trafficking of Osteoclast Precursors
    Bouchra Edderkaoui; Fiscal Year: 2012
    ....
  27. Role of HDAC7 in T-cell Development
    ERIC M VERDIN; Fiscal Year: 2010
    ..abstract_text> ..
  28. Engineered tumor-specific T cells Resist Hypoxic-Tumor Immunosuppressive Attacks.
    Patricia Yotnda; Fiscal Year: 2013
    ..3) Such protected T cells can be redirected to additional tumor targets by forced expression of chimeric antigen receptors, reducing tumor escape by antigen loss and broadening the applicability of the engineered cells to a ..
  29. GUCY2C targeted adoptive T cell therapy to treat metastatic colorectal cancer
    Michael S Magee; Fiscal Year: 2013
    ..genetically engineered T cells targeted to the tumor antigen guanylyl cyclase C (GUCY2C) by chimeric antigen receptors. GUCY2C is the index example of a class of proteins termed cancer mucosa antigens, expressed selectively in ..
  30. Functional role of RAG2 H3K4me3 interaction in V(D)J recombination
    Marjorie Oettinger; Fiscal Year: 2009
    ..abstract_text> ..
  31. A TRANSCRIPTION FACTOR WITHIN LIPID RAFTS MODULATES B CELL SIGNALING VIA THE BCR
    Philip W Tucker; Fiscal Year: 2010
    ..Understanding how lipid rafts-localized Bright modulates immune responses will impact on our understanding of immunological tolerance, the immune mechanism that prevents the immune system from reacting against self;i.e., autoimmunity. ..
  32. The adoptive transfer of gene-modified T cells as a cell therapy for lymphoma
    MARCO L DAVILA; Fiscal Year: 2012
    ..the aims of this proposal, which are dedicated to investigating T cells genetically modified with chimeric antigen receptors (CARs) to target them to tumors...
  33. Pre-BCR Function Selecting Novel B Cell Receptors in Chronic Lymphocytic Leukemia
    Kyoko Hayakawa; Fiscal Year: 2010
    ....
  34. T Cell Modulation by NKG2D
    Thomas Spies; Fiscal Year: 2013
    ..Conversely, enhancing this mechanism in autoimmune disease patients may lower disease activity. The results of our studies may thus lead to development of new therapies. ..
  35. Gene-engineered adoptive T cell immunotherapy of GBM
    Laura A Johnson; Fiscal Year: 2012
    ..Genes encoding highly avid T cell receptors (TCR) or chimeric antigen receptors (CAR), which combine highly avid antibody variable regions with T cell signaling molecules, induce T cell ..
  36. Molecular Regulation of VH Gene Replacement in Human Immature B Cells
    Zhixin Zhang; Fiscal Year: 2012
    ..Understanding the molecular regulation of VH replacement will have important clinical implications, because the frequencies of VH replacement products are significantly elevated in autoimmune diseases and anti-viral responses. ..
  37. The role of XLF in hematopoietic stem cell maintenance and function
    Shan Zha; Fiscal Year: 2013
    ..The completion of this proposal will establish a link between HSC and primary immunodeficiency that will have general implication in other genomic instability syndromes. ..
  38. Immunoglobulin Constant Region Switch and Hypermutation in the Nurse Shark
    Ellen Hsu; Fiscal Year: 2012
    The adaptive immune system is founded on lymphocytes expressing a vast array of antigen receptors that provide specific recognition in responding to pathogen...
  39. Regulation of CD45 alternative splicing by HNRPLL
    Anjana Rao; Fiscal Year: 2013
    ..expressed in haematopoietic cells, is an essential modulator of signal transduction through the T and B cell antigen receptors (TCR, BCR)...
  40. Spatiotemporal control of recombination by the RAG proteins and ATM
    JANE AMANDA SKOK; Fiscal Year: 2010
    ..We propose to further these studies to understand precisely how these factors achieve these unexpected effects. ..
  41. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
    ..O -'' :6O a"0-5)'' Q.. C^' ::9 4-- >,O E-- o-0 >-O c(6 fl.. 0)0-0_0 .- ((D 1/. o0' :t- can --0 a)- 4)a) 0-Q iii= L"- -P) .-.. (II o( 'nom 0-a ..
  42. Long-Range Genetic and Epigenetic Control of Tcrb Gene Assembly
    Eugene M Oltz; Fiscal Year: 2010
    ..We propose studies to address how precursor T lymphocytes control long-range changes in the spatial organization of T cell receptor beta loci to ensure their proper assembly and pursuant generation of a normal adaptive immune system. ..
  43. Anti-viral and antileukemic T-cell therapy as prophylaxis after HSCT
    Helen E Heslop; Fiscal Year: 2013
    ..abstract_text> ..
  44. BTK SIGNALING IN B CELL SURVIVAL BY BAFF-R
    Wasif N Khan; Fiscal Year: 2011
    ..The proposed research will illuminate novel mechanisms by which Btk regulates B cell survival critical for normal B cell survival in the healthy immune system as well as B cell autoimmune and immunodeficiency diseases. ..
  45. Role of the BCR in B Cell Chronic Lymphocytic Leukemia
    Diane F Jelinek; Fiscal Year: 2013
    ..Through these studies, we aim to add novel insight into the etiology of this disease and are optimistic that this information can be used to devise timely novel therapeutic interventions. ..
  46. Role of ABH1's AP endonuclease activity in immunoglobulin gene diversification
    TINA A MUELLER; Fiscal Year: 2010
    ..normal environments requires a highly adaptive immune system to generate an immense repertoire of distinct antigen receptors. In particular, activation-induced deaminase (AID) and uracil DNA N-glycosylase (Ung) create abasic sites in ..
  47. Regulation of the hematopoietic-cell transmembrane phosphatases CD45 and CD148
    Tanya S Freedman; Fiscal Year: 2010
    ..Understanding the regulation of these signaling proteins will help us better understand the balance of signals necessary for maintaining appropriate growth patterns and sensitivity in immune cells ..
  48. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..Our studies will provide a greater understanding of their mechanism of action and contribution to allergic inflammation. This new knowledge could help to develop better approaches to treat allergy and asthma. ..
  49. ATM FUNCTION DURING V(D)J RECOMBINATION
    Barry P Sleckman; Fiscal Year: 2013
    ..Furthermore, we will elucidate the mechanisms that lead to the frequent aberrant resolution of DNA breaks as chromosomal translocations in ATM-deficient cells. ..
  50. Chemokine-related acute lung injury pathogenesis in African-American patients
    Kirsten Neudoerffer Kangelaris; Fiscal Year: 2013
    ..This research will form the basis for an R01-level application to study the association between chemokine-related genomic and protein markers and acute lung injury susceptibility and outcomes in African-American patients. ..
  51. An Advanced Model to Analyze CD4T Cel Reactions to Antibody and BCR V Regions
    Lawrence J Wysocki; Fiscal Year: 2012
    ..mouse for genetic analyses of T cell reactions to V region peptides derived from antibodies and B cell antigen receptors (BCR). CD4 T cells make a living by interacting with B cells that present antigenic peptides in MHC II...
  52. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2013
    ..These studies will lead to a greater understanding of both the generation of the immune system of those processes that lead to leukemia. ..
  53. Strategies to enhance immune reconstitution after bone marrow transplant
    Marcel R m van den Brink; Fiscal Year: 2013
    ..We also plan to engineer an artificial hematopoietic niche for T cell development that can be implanted to enhance T cell development. ..
  54. Use of Genetically Engineered T cells Targeting Tumor Stroma to Treat Lung Cancer
    STEVEN MARK ALBELDA; Fiscal Year: 2013
    ..If our strategy proves effective, this project will likely have additional significace beyond lung cancer, since FAP could be targeted in many tumors. ..
  55. THE V(D)J RECOMBINATION REACTION AND ITS IMPACT ON LYMPHOCYTE DEVELOPMENT
    Barry P Sleckman; Fiscal Year: 2013
    ....
  56. Enhancing T Cell Therapy of Cancer
    Cliona M Rooney; Fiscal Year: 2013
    ..This series of iterative laboratory and linked clinical studies is expected to yield strategies with the potential to increase cure rates and reduce treatment-related toxicity in patients with a spectrum of resistant solid tumors. ..
  57. Targeting Daxx-mediated complex for autoimmune diseases
    Jianke Zhang; Fiscal Year: 2013
    ..Successful completion of these specific aims will provide new insight into the mechanisms of the action by Daxx and lead to better design of measures for prevention and treatment of autoimmune and related diseases. ..
  58. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2010
    ..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor, which drive specific steps in lymphocyte development, and to determine the genes involved in this process. ..
  59. Functions of Bcl10 in Lymphocytes
    Renren Wen; Fiscal Year: 2009
    ..abstract_text> ..
  60. The Role of ATM in Suppression of Lymphomas
    Shan Zha; Fiscal Year: 2013
    ....
  61. The role of IL-7 in guiding developing B cells through the pre-B cell check-point
    Kristen Johnson; Fiscal Year: 2010
    ..Ultimately, this work will lead to the generation of new therapeutic targets for the treatment of B cell ALL. ..
  62. Strategies to improve the adoptive transfer of T cells
    Stanley R Riddell; Fiscal Year: 2013
    ..The results of these studies are directly relevant for treatment of patients with cancer by adoptive T cell therapy. ..
  63. Molecular mechanism of immune evasion by Yersinia pestis
    Tomas Mustelin; Fiscal Year: 2003
    ..This information, together with a specific YopH inhibitor that works in the same T cell activation model, will represent valuable progress towards the goal of designing a drug to combat plague mortality. ..
  64. Analysis of Human B Cell Tolerance in Humanized Mice
    Roberta Pelanda; Fiscal Year: 2009
    ..These novel systems will also be amenable for testing novel potential therapeutics on patient cells. ..
  65. IL-1 RECEPTORS AND CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 2003
    ..to host defense strategies first employed by primitive multicellular organisms prior to the evolution of antigen receptors on B and T cells (acquired immunity) in vertebrates...
  66. Targeting the B Cell Receptor Signaling Network in Lymphoma
    Jonathan Irish; Fiscal Year: 2009
    ..This award would significantly advance my long term career goal of using biological and computational tools to create personalized, effective therapies for human cancer. ..
  67. Targeted antigen receptor treatment of cancer
    David Scheinberg; Fiscal Year: 2009
    ..proposal continues this tradition through targeting tissue-specific antigens for cancer therapy using antigen receptors. The rationale is based on the remarkable specificity of the antigen receptors on T cells and B cells...
  68. MEMBRANES AND SIGNAL TRANSDUCTION
    BARTHOLOMEW SEFTON; Fiscal Year: 2001
    ....
  69. MOLECULAR CONTROL OF ANTIGEN RECEPTOR GENE ASSEMBLY
    Eugene Oltz; Fiscal Year: 2000
    ..employ a complex series of recombination events (V(D)J recombination) to assemble the enormous diversity of antigen receptors required to mount an effective immune response...
  70. Universal MUC1 Targeted Immunotherapy
    Rimas Orentas; Fiscal Year: 2009
    ..cells with significant anti-tumor efficacy can be created by developing improved "third generation" chimeric antigen receptors (CAR) that will target and specifically kill MUC1+ cancers...
  71. CD45 REGULATION OF T CELL TYROSINE KINASES
    Christopher Burns; Fiscal Year: 2000
    ..Furthermore, our results may suggest specific strategies to interrupt aberrant immune responses at a very proximal site, potentially through specific targeting of these PTKs or CD45 itself. ..