dopamine d2 receptors

Summary

Summary: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.

Top Publications

  1. ncbi Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 96:482-8. 2006
  2. ncbi Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors
    Gemma Navarro
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain
    J Biol Chem 284:28058-68. 2009
  3. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
  4. ncbi Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    Paul M Johnson
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida, USA
    Nat Neurosci 13:635-41. 2010
  5. ncbi Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms
    Ahmed Hasbi
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Pharmacol 10:93-9. 2010
  6. ncbi Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, Children's Hospital and Regional Medical Center, Seattle, WA 98105 USA
    Neuron 42:653-63. 2004
  7. ncbi Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor
    M Glass
    Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892 4090, USA
    J Neurosci 17:5327-33. 1997
  8. ncbi Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Mol Psychiatry 4:290-6. 1999
  9. ncbi Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women
    Petra Kok
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 291:E1038-43. 2006
  10. ncbi Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
    Nat Neurosci 5:169-74. 2002

Research Grants

  1. Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling
    David P Siderovski; Fiscal Year: 2010
  2. Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling
    DAVID SIDEROVSKI; Fiscal Year: 2009
  3. Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling
    David P Siderovski; Fiscal Year: 2010
  4. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
  5. Antipsychotic Drugs and Maternal Behavior: A Preclinical Investigation
    Ming Li; Fiscal Year: 2007
  6. New Dopamine D1 Agonists as PET Imaging Agents
    ONOFRE DEJESUS; Fiscal Year: 2007
  7. Amphetamine sensitization in a model of schizophrenia
    Russell Brown; Fiscal Year: 2006
  8. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2010
  9. NEURONAL PLASTICITY IN THE RETINA
    Stuart C Mangel; Fiscal Year: 2010
  10. Structure and function of dopamine receptors
    JONATHAN JAVITCH; Fiscal Year: 2009

Detail Information

Publications215 found, 100 shown here

  1. ncbi Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 96:482-8. 2006
    In the striatum, stimulation of dopamine D2 receptors results in attenuation of glutamate responses. This effect is exerted in large part via negative regulation of AMPA glutamate receptors...
  2. ncbi Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors
    Gemma Navarro
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain
    J Biol Chem 284:28058-68. 2009
    ..These results may have implications for basal ganglia disorders, since A(2A)-D(2) receptor heteromers are being considered as a target for anti-parkinsonian agents...
  3. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
    ....
  4. ncbi Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    Paul M Johnson
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida, USA
    Nat Neurosci 13:635-41. 2010
    ..Striatal dopamine D2 receptors (D2Rs) were downregulated in obese rats, as has been reported in humans addicted to drugs...
  5. ncbi Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms
    Ahmed Hasbi
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Pharmacol 10:93-9. 2010
    ..These novel receptor heteromeric complexes, for the first time, establish the link between dopamine action and rapid calcium signaling...
  6. ncbi Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, Children's Hospital and Regional Medical Center, Seattle, WA 98105 USA
    Neuron 42:653-63. 2004
    ..Thus, dopamine, by filtering less active inputs, appears to reinforce specific sets of corticostriatal synaptic connections...
  7. ncbi Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor
    M Glass
    Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892 4090, USA
    J Neurosci 17:5327-33. 1997
    ..Within the striatum, CB1 receptors have been shown to be localized on the same neurons as Gi-coupled dopamine D2 receptors. In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase...
  8. ncbi Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Mol Psychiatry 4:290-6. 1999
    The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects. This variability might be due to genetic or environmental factors...
  9. ncbi Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women
    Petra Kok
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 291:E1038-43. 2006
    ..Thus these results imply that short-term bromocriptine treatment ameliorates various components of the metabolic syndrome while it shifts energy balance away from lipogenesis in obese humans...
  10. ncbi Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA
    Nat Neurosci 5:169-74. 2002
    ..monkeys did not differ during individual housing, social housing increased the amount or availability of dopamine D2 receptors in dominant monkeys and produced no change in subordinate monkeys...
  11. ncbi A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome, Italy
    Neuropsychopharmacology 29:1488-97. 2004
    ..Understanding the molecular and physiological effects of drugs of abuse in the brain is essential for the development of effective strategies against addiction...
  12. ncbi Dopamine D2 receptors form higher order oligomers at physiological expression levels
    Wen Guo
    Center for Molecular Recognition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    EMBO J 27:2293-304. 2008
    ..bioluminescence/fluorescence complementation and energy transfer to demonstrate that at least four dopamine D2 receptors are located in close molecular proximity in living mammalian cells, consistent with their organization as ..
  13. ncbi Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking
    R P Ebstein
    Research Laboratory, S. Herzog Memorial Hospital, Jerusalem, Israel
    Nat Genet 12:78-80. 1996
  14. ncbi The role of dopamine receptors in regulating the size of axonal arbors
    C L Parish
    Neurosciences Group, Department of Medicine and Department of Neurology, Monash Medical Center, Clayton 3168, Australia
    J Neurosci 21:5147-57. 2001
    ..These results suggest that individual dopaminergic axons in D2(-/-) mice have reached maximal arbor size. We conclude that the D2 receptor may play a role in modulating the extent of the terminal arbor of SNpc neurons...
  15. ncbi Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..A consistent finding in drug-addicted subjects is a lower level of dopamine D2 receptors. In cocaine abusers, low levels of D2 receptors are associated with a lower level of metabolism in the ..
  16. ncbi Dopamine modulates release from corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, USA
    J Neurosci 24:9541-52. 2004
    ..Microdialysis revealed that basal extracellular striatal glutamate was normal in DD mice. These data indicate that dopamine deficiency results in morphologically normal corticostriatal terminals with hypersensitive D2 receptors...
  17. ncbi L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    M A Cenci
    Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
    Eur J Neurosci 10:2694-706. 1998
    ..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
  18. ncbi Activation of ATP-sensitive K+ (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release
    Marat V Avshalumov
    Department of Physiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:11729-34. 2003
    ..These data not only demonstrate that KATP channels can modulate CNS transmitter release in response to fast-synaptic transmission but also introduce H2O2 as a KATP-channel regulator...
  19. ncbi Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers
    Mitul A Mehta
    Department of Psychiatry, Level E4, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 176:331-42. 2004
    ..These include working memory and set-shifting deficits. Theories of DA function have predicted that distraction or impaired switching may be important determinants of such deficits...
  20. ncbi Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population
    Elitza T Betcheva
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Tokyo, Japan
    J Hum Genet 54:98-107. 2009
    ..Our findings support one of the most widely considered hypotheses for schizophrenia etiology, the dopaminergic hypothesis...
  21. ncbi Altered dopamine release and uptake kinetics in mice lacking D2 receptors
    Yvonne Schmitz
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:8002-9. 2002
    ..These results from D2-null mutant mice support the suggestion that D2 autoreceptors and dopamine transporters interact to regulate the amplitude and timing of dopamine signals...
  22. ncbi Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents
    S M Hersch
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 15:5222-37. 1995
    ..These findings demonstrate differential patterns of expression of D1 and D2 receptors in striatal neurons and axon terminals and their differential involvement in motor corticostriatal circuits...
  23. ncbi Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y, USA
    Am J Psychiatry 156:1440-3. 1999
    ..This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans...
  24. ncbi Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4)
    M I Seaman
    Department of Anthropology, Yale University, New Haven, Connecticut 06520 8005, USA
    Am J Med Genet 88:705-9. 1999
    ..The frequency of this derived duplication allele ranges from 0.40-0.81 in the 11 populations from around the world typed for this polymorphism. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:705-709, 1999...
  25. ncbi Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
    Joelle Hillion
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    J Biol Chem 277:18091-7. 2002
    ..These results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D(2)R are involved...
  26. ncbi Reduced striatal D2 receptor binding in myoclonus-dystonia
    R J Beukers
    Department of Neurology, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:269-74. 2009
    ..To study striatal dopamine D(2) receptor availability in DYT11 mutation carriers of the autosomal dominantly inherited disorder myoclonus-dystonia (M-D)...
  27. ncbi Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women
    Petra Kok
    Department of Internal Medicine C4 83, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 91:3236-40. 2006
    ..This study was done to establish the effect of bromocriptine treatment on circadian plasma leptin concentrations in obese humans...
  28. ncbi Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models
    Sridhar Natesan
    Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 31:1854-63. 2006
    ..Partial agonism of aripiprazole offers a good explanation for this dissociation and provides a framework for understanding occupancy-functional relationships of partial D2 agonist antipsychotics...
  29. ncbi Effects of dopaminergic and serotonergic manipulation on emotional processing: a pharmacological fMRI study
    Hidehiko Takahashi
    Brain Imaging Project, National Institute of Radiological Sciences, Japan
    Neuroimage 27:991-1001. 2005
    ..At the same time, our findings suggest that pharmacological fMRI could be a powerful tool for investigating the neurophysiological properties of drugs targeting neuropsychiatric disorders...
  30. ncbi Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457
    Sargo Aalto
    Turku PET Centre, University of Turku, FIN-20014 Turku, Finland
    J Neurosci 25:2471-7. 2005
    ..Our results indicate that regionally specific components of the frontotemporal dopaminergic network are functionally involved in WM performance in humans...
  31. ncbi 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation
    S Kapur
    Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, Ont, Canada
    Am J Psychiatry 155:921-8. 1998
    ..The purpose of this study was to investigate olanzapine's binding to the serotonin 5-HT2 and dopamine D2 receptors in schizophrenic patients being treated with clinically relevant doses.
  32. ncbi The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus
    E Wang
    Department of Biological Chemistry, University of California at Irvine, Irvine, CA 92697, USA
    Am J Hum Genet 74:931-44. 2004
    ..We propose a model for selection at the DRD4 locus consistent with these observed LD patterns and with the known biochemical and physiological differences between receptor variants...
  33. ncbi Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 128:1605-12. 2005
    ..We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]beta-CIT SPECT in patients with uncertain parkinsonism...
  34. ncbi Improved short-term spatial memory but impaired reversal learning following the dopamine D(2) agonist bromocriptine in human volunteers
    M A Mehta
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, UK
    Psychopharmacology (Berl) 159:10-20. 2001
    ..Studies in humans of cognitive effects of dopaminergic drugs have largely focused on tasks of working memory, with a few studies also examining executive function...
  35. ncbi Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function
    Carla Ferrada
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, University of Barcelona, 08028 Barcelona, Spain
    Neuropharmacology 55:190-7. 2008
    ..This study demonstrates an important role of postsynaptic H(3) receptors in the modulation of dopaminergic transmission by means of a negative modulation of D(2) receptor function...
  36. ncbi Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
    J H Baik
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Nature 377:424-8. 1995
    ..Here we have studied the physiological involvement of the dopamine D2 receptors in dopaminergic transmission, using homologous recombination to generate D2-receptor-deficient mice...
  37. ncbi High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Boulevard, Rockville, MD 20857, USA
    Arch Gen Psychiatry 63:999-1008. 2006
    ..Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption...
  38. ncbi Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y 11973, USA
    Am J Psychiatry 154:50-5. 1997
    ..The authors' goals were to determine whether baseline dopamine activity contributes to response to methylphenidate and to assess the pattern of metabolic responses associated with enhanced dopamine activity...
  39. ncbi Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene
    Z Ronai
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest POB 260, 1444, Hungary
    Mol Psychiatry 6:35-8. 2001
    ..06). Examination of this relation in male and female sex groups, however, strengthened the association for females (P < 0.01), but showed no genotypic effect for males...
  40. ncbi Getting specialized: presynaptic and postsynaptic dopamine D2 receptors
    Claudia De Mei
    University of California Irvine, Department of Microbiology and Molecular Genetics, 3113 Gillespie NRF, Irvine, CA 92617 USA
    Curr Opin Pharmacol 9:53-8. 2009
    ..Recent results from knockout mice are clarifying the role of site and D2 isoform-specific effects thereby increasing our understanding of how DA modulates neuronal physiology...
  41. ncbi Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action
    S Kapur
    Department of Psychiatry, University of Toronto, Ont
    J Psychiatry Neurosci 25:161-6. 2000
    While the blockade of dopamine D2 receptors are necessary for antipsychotic action, antipsychotic agents differ nearly a thousand-fold in their affinity for the D2 receptor...
  42. ncbi Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized mice
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Neuropharmacology 55:230-7. 2008
    ..This activation is associated to enhanced psychomotor sensitization and may be implicated in context-elicited drug seeking induced by repeated exposure to drugs of abuse...
  43. ncbi Anti-proliferative effects and cell death mediated by two isoforms of dopamine D2 receptors in pituitary tumor cells
    Juan Ji An
    Laboratory of Molecular Biology, Medical Research Center, College of Medicine, Brain Korea 21 Project for Medical Sciences, Yonsei University, Shinchon Dong 134, Seodaemun gu, Seoul 120 752, South Korea
    Mol Cell Endocrinol 206:49-62. 2003
    ..were blunted by haloperidol, indicating that dopamine-induced cell death in these cells is mediated by the dopamine D2 receptors. D2 receptor-mediated cell death in these cells correlated with the sustained and enhanced activation of ..
  44. ncbi Effects of selective dopamine D1 or D2 receptor blockade within nucleus accumbens subregions on ingestive behavior and associated motor activity
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin-Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
    Behav Brain Res 137:165-77. 2002
    ..These results are discussed with regard to current theories of dopaminergic control of feeding behavior, and with reference to the functional heterogeneity of Acb subregions...
  45. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
    ..The aim of this study was to compare activation of dopamine D2 receptors after amphetamine administration in the functional subdivisions of the human striatum...
  46. ncbi Dopamine D2 receptors as treatment targets in schizophrenia
    Philip Seeman
    Pharmacology Department, Faculty of Medicine, University of Toronto, Canada
    Clin Schizophr Relat Psychoses 4:56-73. 2010
    ..Future goals include imaging D2High receptors and desensitizing them in early-stage psychosis...
  47. ncbi Dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Hum Brain Mapp 20:91-102. 2003
    ..Moreover, WHA provides a useful tool for detailed mapping of neuronal receptors in healthy as well as diseased brain, and can also be used in radioligand development for PET...
  48. ncbi Further evidence for a modulation of Novelty Seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants
    A Strobel
    Mol Psychiatry 8:371-2. 2003
  49. ncbi Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminals
    M Ennis
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurophysiol 86:2986-97. 2001
    ..DA and D2 agonists had no effect in D2 receptor knockout mice, suggesting that D2 receptors are the only type of DA receptors that affect signal transmission from the ON to the rodent olfactory bulb...
  50. ncbi Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase
    David M Mottola
    Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7160, USA
    J Pharmacol Exp Ther 301:1166-78. 2002
    ....
  51. ncbi Downregulation of striatal dopamine D2 receptors in advanced Parkinson's disease contributes to the development of motor fluctuation
    Wen-Jun Hwang
    Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Eur Neurol 47:113-7. 2002
    ..57 +/- 0.20 vs. 1.77 +/- 0.10, p = 0.024). We conclude that the decreased D2 receptor densities in advanced PD reduced the 'safety factor' for synaptic transmission and contributed to the development of motor fluctuation...
  52. ncbi Inhibition of amygdaloid dopamine D2 receptors impairs emotional learning measured with fear-potentiated startle
    Q Greba
    Department of Psychology, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Brain Res 899:218-26. 2001
    ....
  53. ncbi Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors
    J Ahveninen
    Cognitive Brain Research Unit, Department of Psychology, PO Box 13, FIN 00014 University of Helsinki, Helsinki, Finland
    Neurosci Lett 292:29-32. 2000
    ..The present result suggests that dopamine D(2) receptors modulate selective attention...
  54. ncbi Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors
    B A Cox
    Medical Research Service, Veterans Affairs Medical Center, Portland, Oregon 97207
    J Neurochem 59:627-35. 1992
    ....
  55. ncbi Contribution of serine residues to constitutive and agonist-induced signaling via the D2S dopamine receptor: evidence for multiple, agonist-specific active conformations
    B L Wiens
    Medical Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Mol Pharmacol 54:435-44. 1998
    b>Dopamine D2 receptors contain a cluster of serine residues in the fifth transmembrane domain that contribute to activation of the receptor as well as to the binding of agonists...
  56. ncbi Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking
    T Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Anagawa 4-Chome, Inage-ku, Chiba, 263-8555, Japan
    Neuroimage 13:891-5. 2001
    ..We measured extrastriatal dopamine D2 receptors of 24 healthy young male subjects using [(11)C]FLB 457 positron emission tomography...
  57. ncbi The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics
    Romina Mizrahi
    Centre for Addiction and Mental Health, PET Centre, Toronto, ON, Canada
    Int J Neuropsychopharmacol 12:715-21. 2009
    ..90 (S.D.=15.33), an effect that was sustained for 6 months. This sustained improvement was observed despite very high levels of DA D2 occupancy (82-99%), in contrast to the effects of antagonist antipsychotics on subjective well-being...
  58. ncbi In vivo PET studies of the dopamine D2 receptors in rhesus monkeys with long-term MPTP-induced parkinsonism
    D J Doudet
    Department of Medicine, Division of Neurology and Kinsmen Laboratory of Neurological Research and TRIUMF, University of British Columbia, Vancouver, BC, Canada
    Synapse 38:105-13. 2000
    ..Antiparkinsonian therapy is unlikely to be solely responsible for the lack of upregulation found in advanced parkinsonian patients but may be a contributing factor...
  59. ncbi Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors
    Juan Ji An
    Laboratory of Electrophysiology, Medical Research Center, College of Medicine, Yonsei University, Seoul 120 752, South Korea
    Mol Cell Neurosci 25:732-41. 2004
    The levels of glutamic acid decarboxylase (GAD) were strongly increased in the cortex and the striatum in dopamine D2 receptors null (D2R-/-) mice, which show a significant locomotor impairment...
  60. ncbi Genetic polymorphism of dopamine D2 receptors in Parkinson's disease and interactions with cigarette smoking and MAO-B intron 13 polymorphism
    P Costa-Mallen
    Department of Environmental Health, University of Washington School of Public Health and Community Medicine, 4225 Roosevelt Way NE 100, Seattle, WA 98105 6099, USA
    J Neurol Neurosurg Psychiatry 69:535-7. 2000
    Genetic polymorphisms of dopamine D2 receptors (DRD2) may be susceptibility factors for Parkinson's disease due to their influence on dopamine response and association with cigarette smoking, which is inversely related to risk of ..
  61. ncbi Occupancy of dopamine D2 receptors in the mouse brain measured using ultra-high-resolution single-photon emission tomography and [123]IBF
    Paul D Acton
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia 19104, USA
    Eur J Nucl Med Mol Imaging 29:1507-15. 2002
    ..we aimed to demonstrate the feasibility of using ultra-high-resolution SPET to measure the occupancy of dopamine D2 receptors by a competing drug, using the dopamine D2 receptor-specific radioligand iodine-123 5-iodo-7-N-[(1-ethyl-2-..
  62. ncbi Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine
    Marc Welter
    Department of Psychiatry and Human Behavior, University of California, 3113 Gillespie Building, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:6840-5. 2007
    ..Our findings show that the absence of D2R, very likely through a presynaptic mechanism, uncovers an inhibitory signaling pathway normally masked by the activity of this receptor on brain circuitries engaged by abused drugs...
  63. ncbi Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5
    K Ito
    Department of Neurochemistry, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 260:112-9. 1999
    ..D2S receptors expressed in HEK 293 cells were shown to be phosphorylated by GRK2 in an agonist-dependent manner. These results indicate that the sequestration of D2 receptors occurs only through a GRK-mediated pathway...
  64. ncbi Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease
    J C H van Oostrom
    Department of Neurology, Groningen University Medical Center, Groningen, The Netherlands
    Neurology 65:941-3. 2005
    ..0005). Dopamine D2 receptor availability measured by RAC-BP seems the most sensitive indicator of early neuronal impairment in PMC...
  65. ncbi Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:20552-7. 2007
    ..Our results identify regulatory DRD2 polymorphisms that modify mRNA expression and splicing and working memory pathways...
  66. ncbi Association between the type 4 dopamine receptor gene polymorphism and novelty seeking
    Liisa Keltikangas-Jarvinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Psychosom Med 65:471-6. 2003
    ..Mixed results have been reported on the association between the type 4 dopamine receptor gene (DRD4) and the temperament dimension of novelty seeking. We tested this association by specifying the analysis to components of novelty seeking...
  67. ncbi Trafficking of adenosine A2A and dopamine D2 receptors
    Maria Torvinen
    Department of Neuroscience, Karolinska Institute, 17 177 Stockholm, Sweden
    J Mol Neurosci 25:191-200. 2005
    An interaction between adenosine A2A and dopamine D2 receptors has been demonstrated previously...
  68. ncbi Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors
    Kyu Seok Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    J Biol Chem 285:8905-17. 2010
    ..Together, our findings suggest that the interaction between the dopaminergic system and leptin signaling in hypothalamus is important in control of energy homeostasis...
  69. ncbi Lack of association between polymorphisms of the dopamine D4 receptor gene and personality
    Alexander Strobel
    Institute of Psychology II, Dresden University of Technology, D 01062 Dresden, Germany
    Neuropsychobiology 47:52-6. 2003
    ..Hence, our data do not provide evidence for a role of DRD4 exon III and the -521C/T polymorphism in the modulation of novelty seeking and extraversion...
  70. ncbi A role for dopamine D2 receptors in reversal learning
    D A De Steno
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Neuroscience 162:118-27. 2009
    ..Here we show that mice lacking dopamine D2 receptors exhibited significantly impaired performance in the reversal learning phase of an attention-set-shifting ..
  71. ncbi Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease
    N Kemppainen
    Department of Neurology, PO Box 52, University of Turku, FIN-20521 Turku, Finland
    Eur J Neurosci 18:149-54. 2003
    Post mortem studies have revealed a loss of dopamine D2 receptors in the temporal lobes in Alzheimer's disease (AD). Moreover, the role of hippocampal D2 receptors on memory performance has been suggested in experimental studies...
  72. ncbi Upregulation of dopamine D2 receptors in dopaminergic drug-naive patients with Parkin gene mutations
    Christoph Scherfler
    MRC Clinical Science Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Mov Disord 21:783-8. 2006
    ..with Parkinsonism and parkin gene mutations have been reported to show a significant decrease in striatal dopamine D2 receptors (D2R) in comparison to medicated idiopathic Parkinson's disease (IPD) patients with similar age and ..
  73. ncbi Distinct functions of the two isoforms of dopamine D2 receptors
    A Usiello
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, C U de Strasbourg, France
    Nature 408:199-203. 2000
    Signalling through dopamine D2 receptors governs physiological functions related to locomotion, hormone production and drug abuse...
  74. ncbi Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias
    M R Munafò
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    Mol Psychiatry 12:454-61. 2007
    ....
  75. ncbi Dopamine D2 receptors are present in prefrontal cortical afferents and their targets in patches of the rat caudate-putamen nucleus
    Hong Wang
    Division of Neurobiology, Department of Neurology and Neuroscience, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 442:392-404. 2002
    ..Activation of dopamine D2 receptors is known to potently modulate striatal glutamatergic transmission and may play a role in reward-based ..
  76. ncbi Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum
    S D Dickinson
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Neurochem 72:148-56. 1999
    ..These results further strengthen the idea that the D2 DA receptor subtype modulates activity of the striatal DAT...
  77. ncbi Effects of catecholamine depletion on D2 receptor binding, mood, and attentiveness in humans: a replication study
    Nicolaas P L G Verhoeff
    Kunin Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Posluns Building, 7th Floor, Room 762, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Pharmacol Biochem Behav 74:425-32. 2003
    ..These changes were not correlated with the D(2)RBP increments. The results of this study are overall consistent with previous findings by our group using the same methodology in a different cohort of six healthy subjects...
  78. ncbi Subjective experiences during dopamine depletion
    Lieuwe De Haan
    Am J Psychiatry 162:1755. 2005
  79. ncbi PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 9:1050-6. 2006
    ..Individual differences in the rate of recovery of D2 receptor function during abstinence were noted...
  80. ncbi Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics
    C Cruz
    Departamento de Genética Psiquiátrica, Instituto Mexicano de Psiquiatría Calzada Mexico Xochimilco, San Lorenzo Huipulco, Mexico D F
    Neurosci Lett 231:1-4. 1997
    ..66, P = 0.03). Our study suggests that the seven-repeat allele of the DRD4 gene could be a factor in the phenotypic variance of tics among OCD individuals...
  81. ncbi Inhibition of dopamine release via presynaptic D2 receptors: time course and functional characteristics in vivo
    M Benoit-Marand
    Centre National de la Recherche Scientifique Unite Mixte de Recherche 5541, Universite Victor Segalen, 33076 Bordeaux, France
    J Neurosci 21:9134-41. 2001
    ..First, it contributes to the attenuation of extracellular dopamine during bursts. Second, autoinhibition elicited by one burst transiently attenuates further dopamine release elicited by tonic activity...
  82. ncbi Association between dopamine-related polymorphisms and plasma concentrations of prolactin during risperidone treatment in schizophrenic patients
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, and Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki 036 8562, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1491-5. 2008
    ..These findings suggest that plasma prolactin concentrations in females are much higher than in males but the dopamine-related variants are not predominantly associated with plasma concentration of prolactin...
  83. ncbi Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding
    Simon Cervenka
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Brain 129:2017-28. 2006
    ..The results do not support variations in dopamine D2-receptor availability as a correlate to the diurnal rhythm of RLS symptoms...
  84. ncbi Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biol Psychiatry 65:1024-31. 2009
    ..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
  85. ncbi Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 116:163-72. 2002
    ..These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor...
  86. ncbi Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors
    Francisco Ciruela
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, E-08028, Spain
    Anal Chem 76:5354-63. 2004
    ..The present results are the first example of epitope-epitope electrostatic interaction underlying receptor heteromerization, a new, expanding area of protein-protein interactions...
  87. ncbi Identification of first candidate genes for creativity: a pilot study
    Martin Reuter
    Department of Psychology, Justus Liebig University of Giessen, Otto Behaghel Str 10F, D 35394 Giessen, Germany
    Brain Res 1069:190-7. 2006
    ....
  88. ncbi Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Arch Gen Psychiatry 61:597-606. 2004
    ..Dopamine receptor-mediated pathways play critical roles in the mechanism of addiction. However, associations of the D(2) dopamine receptor gene (DRD2) with substance abuse are controversial...
  89. ncbi The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects
    Sargo Aalto
    Turku PET Centre, University of Turku, 20014 Turku, Finland
    Eur J Nucl Med Mol Imaging 36:475-83. 2009
    ..The dopamine D(2)/D(3) receptor ligand [(11)C]FLB 457 and PET enable quantification of low-density extrastriatal D(2)/D(3) receptors, but it is uncertain whether [(11)C]FLB 457 can be used for measuring extrastriatal dopamine release...
  90. ncbi Evidence for a differential medial prefrontal dopamine D1 and D2 receptor regulation of local and ventral tegmental glutamate and GABA release: a dual probe microdialysis study in the awake rat
    M Harte
    Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK
    Brain Res 1017:120-9. 2004
    ....
  91. ncbi Protective effects of N-acetylserotonin against 6-hydroxydopamine-induced neurotoxicity
    Lissiana Magna Aguiar
    Universidade Federal do Ceara, Fortaleza, Brazil
    Life Sci 76:2193-202. 2005
    ..NAS was more efficient at the smaller doses. NAS (5 mg/kg) produced an up-regulation of D1 (37%) and D2 (37%) receptors associated with a decrease in Kd values...
  92. ncbi Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons
    Jianping Wu
    Department of Neurobiology, Civitan International Research Center, University of Alabama, Birmingham, Alabama 35294, USA
    J Neurosci 25:6322-8. 2005
    ..These results indicate that Ih contributes to the resting potential of layer I interneurons and is subject to modulation by dopamine...
  93. ncbi Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms
    Kuei Y Tseng
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurosci 24:5131-9. 2004
    ..Thus, the modulatory actions of D1 and D2 receptors on PFC pyramidal cell excitability are mediated by multiple intracellular mechanisms and by activation of GABA(A) receptors, depending on the glutamate receptor subtypes involved...
  94. ncbi Repeated apomorphine administration alters dopamine D1 and D2 receptor densities in pigeon basal telencephalon
    Martin J Acerbo
    Experimental Psychology, University of Konstanz, 78457, Konstanz, Germany
    Exp Brain Res 160:533-7. 2005
    ..We conclude that extended apomorphine treatment modifies the D(1) dopamine receptor density in the opposite manner to the D(2) dopamine receptor density...
  95. ncbi Negative feedback regulation of nigrostriatal dopamine release: mediation by striatal D1 receptors
    Sanjida S Saklayen
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
    J Pharmacol Exp Ther 311:342-8. 2004
    ..Knowledge of the circuitry underlying D1-mediated regulation of nigrostriatal neurons may have significance in current research on treatments for Parkinson's disease...
  96. ncbi The role of dopamine in a model of trigeminovascular nociception
    S Akerman
    Institute of Neurology, Queen Square, London, WC1N 3BG UK
    J Pharmacol Exp Ther 314:162-9. 2005
    ..Our data do not exclude a role for dopamine receptor modulators in short- or long-term prevention...
  97. ncbi D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways
    Abraham Kovoor
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 25:2157-65. 2005
    ..Thus, alterations in RGS9-2 may be a key factor in the pathway leading from D2DRs to the side effects associated with the treatment both of psychoses and Parkinson's disease...
  98. ncbi Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release
    Davide Quarta
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 32:35-42. 2007
    ..These results reveal that striatal non-alpha(7) nicotinic acetylcholine receptors form part of heteromeric dopamine autoreceptor complexes that modulate dopamine release...
  99. ncbi Neurochemical and behavioral responses to cocaine in adult male rats with neonatal isolation experience
    Therese A Kosten
    Division of Substance Abuse, Yale University School of Medicine, VA Connecticut Hospital System, 950 Campbell Avenue, Bldg 5, 3rd Floor, West Haven, CT 06516, USA
    J Pharmacol Exp Ther 314:661-7. 2005
    ..Moreover, that ISO rats are more sensitive to a D(2) antagonist may reflect decreased levels of this receptor type as we showed previously in infant rats...
  100. ncbi The role of dopamine in reinforcement: changes in reinforcement sensitivity induced by D1-type, D2-type, and nonselective dopamine receptor agonists
    Natalie A Bratcher
    Illinois State University, Normal 61790-4620, USA
    J Exp Anal Behav 84:371-99. 2005
    ....
  101. ncbi Differential roles of dopamine D1 and D2 receptors in the nucleus accumbens in attentional performance on the five-choice serial reaction time task
    Marie Astrid Pezze
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:273-83. 2007
    ..The data are discussed in terms of the different functions of NAC dopamine receptors in the processing of information from its different cortico-limbic inputs...

Research Grants75

  1. Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling
    David P Siderovski; Fiscal Year: 2010
    ....
  2. Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling
    DAVID SIDEROVSKI; Fiscal Year: 2009
    ....
  3. Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling
    David P Siderovski; Fiscal Year: 2010
    ....
  4. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
    ..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
  5. Antipsychotic Drugs and Maternal Behavior: A Preclinical Investigation
    Ming Li; Fiscal Year: 2007
    ..as the representative of atypical antipsychotic drugs) disrupts maternal behavior via the blocking of dopamine D2 receptors and/or 5-HT2A receptors...
  6. New Dopamine D1 Agonists as PET Imaging Agents
    ONOFRE DEJESUS; Fiscal Year: 2007
    ..While PET imaging agents targeted to dopamine D2 receptors are well developed, the same can not be said for dopamine D1 PET imaging agents...
  7. Amphetamine sensitization in a model of schizophrenia
    Russell Brown; Fiscal Year: 2006
    ....
  8. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2010
    ..This research studies the neurobiological mechanisms underlying sensitization in brain dopamine D2 receptors that would exacerbate drug craving and relapse in cocaine users, and investigates novel approaches to ..
  9. NEURONAL PLASTICITY IN THE RETINA
    Stuart C Mangel; Fiscal Year: 2010
    ..order cell that receives synaptic contact from cones, by controlling rod-cone gap junctional coupling via dopamine D2 receptors. Preliminary evidence suggests that the retinal clock also regulates rod and cone input to ganglion cells, ..
  10. Structure and function of dopamine receptors
    JONATHAN JAVITCH; Fiscal Year: 2009
    ....
  11. Molecular mechanisms of Vitex agnus-castus L. in PMS
    Zaijie Jim Wang; Fiscal Year: 2005
    ..Recent studies suggest that activation of dopamine D2 receptors and inhibition of prolactin release may account for part of the effect...
  12. Food reinforcement-genotype interactions and eating
    Leonard Epstein; Fiscal Year: 2009
    ..is mediated in part by the dopaminergic system, and research suggests obesity is related to the density of dopamine D2 receptors. In previous research we found smokers with high food reinforcement who had the A1 allele of the dopamine ..
  13. Food reinforcement-genotype interactions and eating
    Leonard Epstein; Fiscal Year: 2007
    ..is mediated in part by the dopaminergic system, and research suggests obesity is related to the density of dopamine D2 receptors. In previous research we found smokers with high food reinforcement who had the A1 allele of the dopamine ..
  14. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    Virginia M Pickel; Fiscal Year: 2010
    ....
  15. Family Health After Predictive HD Testing
    Janet Williams; Fiscal Year: 2004
    ..study whose purpose is to determine the progressive changes in caudate and putamen volume, basal ganglia dopamine D2 receptors, and determine progressive cognitive and behavioral changes in persons with CAG expansions in the HD gene...
  16. Dietary NMDA-based treatments for schizophrenia
    Michael Kaplowitz; Fiscal Year: 2005
    ..Development of D-serine and/or glycine will be conducted under FDA supervision, and will conform to all required FDA policies and procedures. ..
  17. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    VIRGINIA PICKEL; Fiscal Year: 2007
    ..and from animals receiving chronic treatment with haloperidol, a typical antipsychotic drug that blocks dopamine D2 receptors. Study I will test the hypotheses that (1) the levels of the vesicular monoamine transporter (VMAT2) and ..
  18. Cortical Mechanisms of Cocaine Sensitization
    Jeffery D Steketee; Fiscal Year: 2010
    ..Thus, the proposed studies are relevant in that an increased understanding of the mechanisms of sensitization might lead to improved treatment strategies for cocaine addiction. ..
  19. Ethanol regulation of signaling: from cells to behavior
    Ivan Diamond; Fiscal Year: 2009
    ..A2A receptors in the central nervous system (CNS) and is characterized by co-expression of A2A with dopamine D2 receptors (D2) on the same neurons...
  20. Cortical Mechanisms of Cocaine Sensitization
    JEFFERY STEKETEE; Fiscal Year: 2009
    ..Thus, the proposed studies are relevant in that an increased understanding of the mechanisms of sensitization might lead to improved treatment strategies for cocaine addiction. ..
  21. Maintenance Treatment for Smoking Cessation
    Joel Killen; Fiscal Year: 2004
    ....
  22. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2009
    ..We have optimized 5- hydroxyaminotetralins for imaging dopamine D2 receptors which has resulted in the development of 18F-5- OH-FPPAT as a suitable imaging agent...
  23. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2009
    ..We have optimized 5- hydroxyaminotetralins for imaging dopamine D2 receptors which has resulted in the development of 18F-5- OH-FPPAT as a suitable imaging agent...
  24. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2007
    ..We have optimized 5- hydroxyaminotetralins for imaging dopamine D2 receptors which has resulted in the development of 18F-5- OH-FPPAT as a suitable imaging agent...