dopamine d2 receptors

Summary

Summary: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.

Top Publications

  1. ncbi Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 96:482-8. 2006
  2. pmc Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors
    Gemma Navarro
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain
    J Biol Chem 284:28058-68. 2009
  3. ncbi Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
  4. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
  5. pmc Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    Paul M Johnson
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida, USA
    Nat Neurosci 13:635-41. 2010
  6. doi Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 166:1056-67. 2010
  7. pmc Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms
    Ahmed Hasbi
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Pharmacol 10:93-9. 2010
  8. pmc Dichotomous dopaminergic control of striatal synaptic plasticity
    Weixing Shen
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 321:848-51. 2008
  9. ncbi Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, Children s Hospital and Regional Medical Center, Seattle, WA 98105 USA
    Neuron 42:653-63. 2004
  10. ncbi Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 5:169-74. 2002

Detail Information

Publications251 found, 100 shown here

  1. ncbi Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 96:482-8. 2006
    In the striatum, stimulation of dopamine D2 receptors results in attenuation of glutamate responses. This effect is exerted in large part via negative regulation of AMPA glutamate receptors...
  2. pmc Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors
    Gemma Navarro
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain
    J Biol Chem 284:28058-68. 2009
    ..These results may have implications for basal ganglia disorders, since A(2A)-D(2) receptor heteromers are being considered as a target for anti-parkinsonian agents...
  3. ncbi Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..A consistent finding in drug-addicted subjects is a lower level of dopamine D2 receptors. In cocaine abusers, low levels of D2 receptors are associated with a lower level of metabolism in the ..
  4. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
    ....
  5. pmc Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    Paul M Johnson
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida, USA
    Nat Neurosci 13:635-41. 2010
    ..Striatal dopamine D2 receptors (D2Rs) were downregulated in obese rats, as has been reported in humans addicted to drugs...
  6. doi Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 166:1056-67. 2010
    ..These findings may have implications for the treatment of psychiatric symptoms such as psychomotor slowing, anergia and fatigue...
  7. pmc Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms
    Ahmed Hasbi
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Pharmacol 10:93-9. 2010
    ..These novel receptor heteromeric complexes, for the first time, establish the link between dopamine action and rapid calcium signaling...
  8. pmc Dichotomous dopaminergic control of striatal synaptic plasticity
    Weixing Shen
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 321:848-51. 2008
    ..In models of Parkinson's disease, this system is thrown out of balance, leading to unidirectional changes in plasticity that could underlie network pathology and symptoms...
  9. ncbi Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, Children s Hospital and Regional Medical Center, Seattle, WA 98105 USA
    Neuron 42:653-63. 2004
    ..Thus, dopamine, by filtering less active inputs, appears to reinforce specific sets of corticostriatal synaptic connections...
  10. ncbi Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 5:169-74. 2002
    ..monkeys did not differ during individual housing, social housing increased the amount or availability of dopamine D2 receptors in dominant monkeys and produced no change in subordinate monkeys...
  11. ncbi Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias
    M R Munafò
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    Mol Psychiatry 12:454-61. 2007
    ....
  12. ncbi Half a century of antipsychotics and still a central role for dopamine D2 receptors
    Shitij Kapur
    Schizophrenia Program, CAMH, Toronto, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1081-90. 2003
    ..g., positive, negative, cognitive, and affective) that can be flexibly used and titrated in the service of patients' presenting psychopathology...
  13. doi Dopamine D2 receptors as treatment targets in schizophrenia
    Philip Seeman
    Pharmacology Department, Faculty of Medicine, University of Toronto, Canada
    Clin Schizophr Relat Psychoses 4:56-73. 2010
    ..Future goals include imaging D2High receptors and desensitizing them in early-stage psychosis...
  14. ncbi Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization
    Taco J de Vries
    Research Institute Neurosciences Vrije Universiteit, Drug Abuse Program, Department of Medical Pharmacology, VU Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 26:18-26. 2002
    ..During early phases of withdrawal (<1 week), activation of dopamine D2 receptors with quinpirole resulted in robust, dose-dependent, reinstatement of (non-reinforced) responding in both ..
  15. ncbi Dopamine modulates excitability of spiny neurons in the avian basal ganglia
    Long Ding
    Department of Zoology, University of Washington, Seattle, Washington 98195 6115, USA
    J Neurosci 22:5210-8. 2002
    ..The diversity of DA actions enables the DA system to fine-tune the dynamics of the song system and allows flexible control over song learning and production...
  16. ncbi Contribution of serine residues to constitutive and agonist-induced signaling via the D2S dopamine receptor: evidence for multiple, agonist-specific active conformations
    B L Wiens
    Medical Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Mol Pharmacol 54:435-44. 1998
    b>Dopamine D2 receptors contain a cluster of serine residues in the fifth transmembrane domain that contribute to activation of the receptor as well as to the binding of agonists...
  17. ncbi Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor
    M Glass
    Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892 4090, USA
    J Neurosci 17:5327-33. 1997
    ..Within the striatum, CB1 receptors have been shown to be localized on the same neurons as Gi-coupled dopamine D2 receptors. In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase...
  18. ncbi Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women
    Petra Kok
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 291:E1038-43. 2006
    ..Thus these results imply that short-term bromocriptine treatment ameliorates various components of the metabolic syndrome while it shifts energy balance away from lipogenesis in obese humans...
  19. ncbi Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
    H H Van Tol
    Department of Pharmacology, University of Toronto, Ontario, Canada
    Nature 350:610-4. 1991
    ..Recognition and characterization of this clozapine neuroleptic site may prove useful in the design of new types of drugs...
  20. pmc Dopamine D2 receptors form higher order oligomers at physiological expression levels
    Wen Guo
    Center for Molecular Recognition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    EMBO J 27:2293-304. 2008
    ..bioluminescence/fluorescence complementation and energy transfer to demonstrate that at least four dopamine D2 receptors are located in close molecular proximity in living mammalian cells, consistent with their organization as ..
  21. ncbi The role of dopamine receptors in regulating the size of axonal arbors
    C L Parish
    Neurosciences Group, Department of Medicine and Department of Neurology, Monash Medical Center, Clayton 3168, Australia
    J Neurosci 21:5147-57. 2001
    ..These results suggest that individual dopaminergic axons in D2(-/-) mice have reached maximal arbor size. We conclude that the D2 receptor may play a role in modulating the extent of the terminal arbor of SNpc neurons...
  22. ncbi Dopamine modulates release from corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, USA
    J Neurosci 24:9541-52. 2004
    ..Microdialysis revealed that basal extracellular striatal glutamate was normal in DD mice. These data indicate that dopamine deficiency results in morphologically normal corticostriatal terminals with hypersensitive D2 receptors...
  23. ncbi Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking
    R P Ebstein
    Research Laboratory, S Herzog Memorial Hospital, Jerusalem, Israel
    Nat Genet 12:78-80. 1996
  24. ncbi L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    M A Cenci
    Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
    Eur J Neurosci 10:2694-706. 1998
    ..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
  25. doi Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population
    Elitza T Betcheva
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Tokyo, Japan
    J Hum Genet 54:98-107. 2009
    ..Our findings support one of the most widely considered hypotheses for schizophrenia etiology, the dopaminergic hypothesis...
  26. pmc Activation of ATP-sensitive K+ (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release
    Marat V Avshalumov
    Department of Physiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:11729-34. 2003
    ..These data not only demonstrate that KATP channels can modulate CNS transmitter release in response to fast-synaptic transmission but also introduce H2O2 as a KATP-channel regulator...
  27. ncbi Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers
    Mitul A Mehta
    Department of Psychiatry, Level E4, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 176:331-42. 2004
    ..These include working memory and set-shifting deficits. Theories of DA function have predicted that distraction or impaired switching may be important determinants of such deficits...
  28. doi Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse
    Christoph Fehr
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    Am J Psychiatry 165:507-14. 2008
    ..However, it is unclear whether similar changes can also be observed in heavy-smoking nicotine-dependent smokers...
  29. ncbi Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors
    P Calabresi
    Clinica Neurologica, Universita di Roma Tor Vergata, Dipartimento Sanita, 00173 Rome, Italy
    J Neurosci 17:4536-44. 1997
    b>Dopamine D2 receptors (D2Rs) are of crucial importance in the striatal processing of motor information received from the cortex. Disruption of the D2R gene function in mice results in a severe locomotor impairment...
  30. ncbi Functional selectivity and classical concepts of quantitative pharmacology
    Jonathan D Urban
    Curriculum in Toxicology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    J Pharmacol Exp Ther 320:1-13. 2007
    ..It also may be timely to revise classic concepts in quantitative pharmacology and relevant pharmacological conventions to incorporate these new concepts...
  31. ncbi Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder
    G J LaHoste
    Department of Physical Medicine and Rehabilitation, University of California, Irvine 92717 4550, USA
    Mol Psychiatry 1:121-4. 1996
    ....
  32. ncbi The role of dopamine in motivation for food in humans: implications for obesity
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Expert Opin Ther Targets 6:601-9. 2002
    ..A better understanding of the role of the DA system in the motivation for food intake will help the development of better therapeutic interventions...
  33. ncbi Altered dopamine release and uptake kinetics in mice lacking D2 receptors
    Yvonne Schmitz
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:8002-9. 2002
    ..These results from D2-null mutant mice support the suggestion that D2 autoreceptors and dopamine transporters interact to regulate the amplitude and timing of dopamine signals...
  34. ncbi Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents
    S M Hersch
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 15:5222-37. 1995
    ..These findings demonstrate differential patterns of expression of D1 and D2 receptors in striatal neurons and axon terminals and their differential involvement in motor corticostriatal circuits...
  35. pmc The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus
    E Wang
    Department of Biological Chemistry, University of California at Irvine, Irvine, CA 92697, USA
    Am J Hum Genet 74:931-44. 2004
    ..We propose a model for selection at the DRD4 locus consistent with these observed LD patterns and with the known biochemical and physiological differences between receptor variants...
  36. pmc Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling
    Henry H Yin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:8251-6. 2006
    ..These results demonstrate a previously unrecognized role for retrograde eCB signaling in reversible and frequency-specific inhibition of glutamate release by the activation of striatal D2Rs...
  37. ncbi Effects of selective dopamine D1 or D2 receptor blockade within nucleus accumbens subregions on ingestive behavior and associated motor activity
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
    Behav Brain Res 137:165-77. 2002
    ..These results are discussed with regard to current theories of dopaminergic control of feeding behavior, and with reference to the functional heterogeneity of Acb subregions...
  38. ncbi Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminals
    M Ennis
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurophysiol 86:2986-97. 2001
    ..DA and D2 agonists had no effect in D2 receptor knockout mice, suggesting that D2 receptors are the only type of DA receptors that affect signal transmission from the ON to the rodent olfactory bulb...
  39. ncbi Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457
    Sargo Aalto
    Turku PET Centre, University of Turku, FIN 20014 Turku, Finland
    J Neurosci 25:2471-7. 2005
    ..Our results indicate that regionally specific components of the frontotemporal dopaminergic network are functionally involved in WM performance in humans...
  40. ncbi Inhibition of amygdaloid dopamine D2 receptors impairs emotional learning measured with fear-potentiated startle
    Q Greba
    Department of Psychology, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Brain Res 899:218-26. 2001
    ....
  41. ncbi Further evidence for a modulation of Novelty Seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants
    A Strobel
    Mol Psychiatry 8:371-2. 2003
  42. ncbi Opposing roles of D1 and D2 receptors in appetitive conditioning
    Yaniv S Eyny
    Department of Psychology and Program in Neurobiology and Behavior, Columbia University, New York, New York 10027, USA
    J Neurosci 23:1584-7. 2003
    ....
  43. pmc Dopamine responsiveness is regulated by targeted sorting of D2 receptors
    Selena E Bartlett
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94608, USA
    Proc Natl Acad Sci U S A 102:11521-6. 2005
    ..Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors...
  44. ncbi Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors
    B A Cox
    Medical Research Service, Veterans Affairs Medical Center, Portland, Oregon 97207
    J Neurochem 59:627-35. 1992
    ....
  45. ncbi D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain
    Y L Hurd
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    J Chem Neuroanat 22:127-37. 2001
    ..The restricted expression of the D1 mRNA to the cortical mantle and to a few forebrain structures indicates a strong involvement of the D1 system in cognitive function...
  46. ncbi Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Mol Psychiatry 4:290-6. 1999
    The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects. This variability might be due to genetic or environmental factors...
  47. ncbi Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1
    Matt J Neville
    Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, UK
    Hum Mutat 23:540-5. 2004
    ..If this is the case, then changes in ANKK1 activity may provide an alternative explanation for previously described associations between the DRD2 Taq1A RFLP and neuropsychiatric disorders such as addiction...
  48. ncbi Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y, USA
    Am J Psychiatry 156:1440-3. 1999
    ..This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans...
  49. ncbi Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4)
    M I Seaman
    Department of Anthropology, Yale University, New Haven, Connecticut 06520 8005, USA
    Am J Med Genet 88:705-9. 1999
    ..The frequency of this derived duplication allele ranges from 0.40-0.81 in the 11 populations from around the world typed for this polymorphism. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:705-709, 1999...
  50. ncbi Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
    Joelle Hillion
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    J Biol Chem 277:18091-7. 2002
    ..These results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D(2)R are involved...
  51. ncbi Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women
    Petra Kok
    Department of Internal Medicine C4 83, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 91:3236-40. 2006
    ..This study was done to establish the effect of bromocriptine treatment on circadian plasma leptin concentrations in obese humans...
  52. ncbi Association of dopamine D3-receptor gene variants with neuroleptic induced akathisia in schizophrenic patients: a generalization of Steen's study on DRD3 and tardive dyskinesia
    P Eichhammer
    Department of Psychiatry, University of Regensburg, Regensburg, Germany
    Am J Med Genet 96:187-91. 2000
    ..9% incidence of AA in schizophrenic patients nonhomozygous for the 2-2 allele (exact P = 0.0223). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:187-191, 2000...
  53. ncbi D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism
    Elizabeth A Bolan
    Integrative Neuroscience Section, National Institute on Drug Abuse Intramural Research Program National Institutes of Health Department of Health and Human Services, Baltimore, MD 21224, USA
    Mol Pharmacol 71:1222-32. 2007
    ..Our data also suggest the possibility of a direct physical interaction between DAT and D(2)R. Together, these results suggest a novel mechanism by which D(2S)R autoreceptors may regulate DAT in the central nervous system...
  54. ncbi A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 29:1488-97. 2004
    ..Understanding the molecular and physiological effects of drugs of abuse in the brain is essential for the development of effective strategies against addiction...
  55. pmc Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function
    Carla Ferrada
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, University of Barcelona, 08028 Barcelona, Spain
    Neuropharmacology 55:190-7. 2008
    ..This study demonstrates an important role of postsynaptic H(3) receptors in the modulation of dopaminergic transmission by means of a negative modulation of D(2) receptor function...
  56. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D(2) receptor parameter measurements in ventral striatum
    O Mawlawi
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cereb Blood Flow Metab 21:1034-57. 2001
    ....
  57. ncbi Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
    J H Baik
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Nature 377:424-8. 1995
    ..Here we have studied the physiological involvement of the dopamine D2 receptors in dopaminergic transmission, using homologous recombination to generate D2-receptor-deficient mice...
  58. doi Reduced striatal D2 receptor binding in myoclonus-dystonia
    R J Beukers
    Department of Neurology, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:269-74. 2009
    ..To study striatal dopamine D(2) receptor availability in DYT11 mutation carriers of the autosomal dominantly inherited disorder myoclonus-dystonia (M-D)...
  59. pmc Induction of striatal long-term synaptic depression by moderate frequency activation of cortical afferents in rat
    Jennifer Ronesi
    Laboratory for Integrative Neuroscience, National Institute of Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    J Physiol 562:245-56. 2005
    ..Our results demonstrate that a prolonged moderate frequency train induces cannabinoid-dependent LTD, further supporting the idea that endocannabinoids play a prominent role in the regulation of long-lasting changes in striatal output...
  60. pmc Getting specialized: presynaptic and postsynaptic dopamine D2 receptors
    Claudia De Mei
    University of California Irvine, Department of Microbiology and Molecular Genetics, 3113 Gillespie NRF, Irvine, CA 92617 USA
    Curr Opin Pharmacol 9:53-8. 2009
    ..Recent results from knockout mice are clarifying the role of site and D2 isoform-specific effects thereby increasing our understanding of how DA modulates neuronal physiology...
  61. ncbi DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients
    Todd Lencz
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:529-31. 2006
    ....
  62. pmc Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biol Psychiatry 65:1024-31. 2009
    ..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
  63. ncbi DRD4 and novelty seeking: results of meta-analyses
    J A Schinka
    James A Haley Veteran Administration Medical Center, Tampa, Florida 33612, USA
    Am J Med Genet 114:643-8. 2002
    ..32. The positive findings are consistent with a polygenic model of influence on fundamental personality dimensions...
  64. ncbi Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models
    Sridhar Natesan
    Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 31:1854-63. 2006
    ..Partial agonism of aripiprazole offers a good explanation for this dissociation and provides a framework for understanding occupancy-functional relationships of partial D2 agonist antipsychotics...
  65. ncbi Effects of dopaminergic and serotonergic manipulation on emotional processing: a pharmacological fMRI study
    Hidehiko Takahashi
    Brain Imaging Project, National Institute of Radiological Sciences, Japan
    Neuroimage 27:991-1001. 2005
    ..At the same time, our findings suggest that pharmacological fMRI could be a powerful tool for investigating the neurophysiological properties of drugs targeting neuropsychiatric disorders...
  66. ncbi 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation
    S Kapur
    Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, Ont, Canada
    Am J Psychiatry 155:921-8. 1998
    ..The purpose of this study was to investigate olanzapine's binding to the serotonin 5-HT2 and dopamine D2 receptors in schizophrenic patients being treated with clinically relevant doses.
  67. pmc A dopaminergic deficit hypothesis of schizophrenia: the path to discovery
    Arvid Carlsson
    Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Dialogues Clin Neurosci 8:137-42. 2006
    ..This hypothesis is driven by suggestive evidence for subpopulations of dopamine D2 receptors delivering contrasting forms of dopaminergic transmission: synaptic receptors, responsible for basic ..
  68. ncbi Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors
    T J Phillips
    Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Nat Neurosci 1:610-5. 1998
    ..studied the ethanol preference and sensitivity of D2-receptor-deficient mice to directly evaluate whether dopamine D2 receptors contribute to alcohol (ethanol) consumption...
  69. pmc Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda MD 20892, USA
    Neuroimage 42:1537-43. 2008
    ..We had previously documented a reduction in dopamine D2 receptors in morbidly obese subjects...
  70. doi Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:447-61. 2009
    ..These findings suggest that [(11)C]FLB 457 is superior to [(11)C]fallypride for measurement of changes in cortical synaptic dopamine...
  71. pmc Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine
    Marc Welter
    Department of Psychiatry and Human Behavior, University of California, 3113 Gillespie Building, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:6840-5. 2007
    ..Our findings show that the absence of D2R, very likely through a presynaptic mechanism, uncovers an inhibitory signaling pathway normally masked by the activity of this receptor on brain circuitries engaged by abused drugs...
  72. ncbi Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding
    Simon Cervenka
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Brain 129:2017-28. 2006
    ..The results do not support variations in dopamine D2-receptor availability as a correlate to the diurnal rhythm of RLS symptoms...
  73. ncbi Improved short-term spatial memory but impaired reversal learning following the dopamine D(2) agonist bromocriptine in human volunteers
    M A Mehta
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, UK
    Psychopharmacology (Berl) 159:10-20. 2001
    ..Studies in humans of cognitive effects of dopaminergic drugs have largely focused on tasks of working memory, with a few studies also examining executive function...
  74. ncbi High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Boulevard, Rockville, MD 20857, USA
    Arch Gen Psychiatry 63:999-1008. 2006
    ..Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption...
  75. ncbi Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y 11973, USA
    Am J Psychiatry 154:50-5. 1997
    ..The authors' goals were to determine whether baseline dopamine activity contributes to response to methylphenidate and to assess the pattern of metabolic responses associated with enhanced dopamine activity...
  76. ncbi Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 128:1605-12. 2005
    ..We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]beta-CIT SPECT in patients with uncertain parkinsonism...
  77. ncbi Anti-proliferative effects and cell death mediated by two isoforms of dopamine D2 receptors in pituitary tumor cells
    Juan Ji An
    Laboratory of Molecular Biology, Medical Research Center, College of Medicine, Brain Korea 21 Project for Medical Sciences, Yonsei University, Shinchon Dong 134, Seodaemun gu, Seoul 120 752, South Korea
    Mol Cell Endocrinol 206:49-62. 2003
    ..were blunted by haloperidol, indicating that dopamine-induced cell death in these cells is mediated by the dopamine D2 receptors. D2 receptor-mediated cell death in these cells correlated with the sustained and enhanced activation of ..
  78. ncbi Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene
    Z Ronai
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest POB 260, 1444, Hungary
    Mol Psychiatry 6:35-8. 2001
    ..06). Examination of this relation in male and female sex groups, however, strengthened the association for females (P < 0.01), but showed no genotypic effect for males...
  79. pmc Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action
    S Kapur
    Department of Psychiatry, University of Toronto, Ont
    J Psychiatry Neurosci 25:161-6. 2000
    While the blockade of dopamine D2 receptors are necessary for antipsychotic action, antipsychotic agents differ nearly a thousand-fold in their affinity for the D2 receptor...
  80. doi Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized mice
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Neuropharmacology 55:230-7. 2008
    ..This activation is associated to enhanced psychomotor sensitization and may be implicated in context-elicited drug seeking induced by repeated exposure to drugs of abuse...
  81. ncbi Comparison of striatal dopamine D2 receptors in Parkinson's disease and progressive supranuclear palsy patients using [123I] iodobenzofuran single-photon emission computed tomography
    Chisako Oyanagi
    Department of Neurology, Human Brain Research Center, Kyoto University Graduate School of Medicine, 54 Shogoin, Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Neuroimaging 12:316-24. 2002
    ....
  82. ncbi High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder
    D L Grady
    Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697, USA
    Mol Psychiatry 8:536-45. 2003
    ..0001. These results suggest that allelic heterogeneity at the DRD4 locus may also contribute to the observed association with ADHD...
  83. ncbi D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
    K L Nowend
    Unit 1020, Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269-1020, USA
    Pharmacol Biochem Behav 69:373-82. 2001
    ..Nevertheless, interference with accumbens DA does appear to set constraints upon which responses are selected for obtaining food, and may impair the ability of animals to overcome work-related response costs in order to obtain food...
  84. pmc Cocaine-induced mu opioid receptor occupancy within the striatum is mediated by dopamine D2 receptors
    Avery R Soderman
    Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Brain Res 1296:63-71. 2009
    ..These results suggest that cocaine, acting via D2 dopamine receptors, can cause the release of an endogenous opioid peptide that binds to mu opioid receptors within the nucleus accumbens...
  85. ncbi Dopaminergic regulation of glucose-induced insulin secretion through dopamine D2 receptors in the pancreatic islets in vitro
    Eswar Shankar
    Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Kochi, India
    IUBMB Life 58:157-63. 2006
    ..Our results suggest that dopamine exerts a differential effect on glucose-induced insulin secretion through dopamine D2 receptor and it is essential for the regulation of glucose-induced insulin secretion by pancreatic islets...
  86. ncbi Dopamine D2 receptors and secretion of FSH and LH: role of sexual steroids on the pituitary of the female rainbow trout
    Coralie Vacher
    Endocrinologie Moleculaire de la Reproduction, UMR CNRS 6026, Campus de Beaulieu, 35042 Rennes Cedex, France
    Gen Comp Endocrinol 127:198-206. 2002
    ..E(2) should contribute in part to decrease the release of FSH. At the end of the reproductive cycle, 17alpha20betaP should reinforce the dopaminergic inhibitory tone...
  87. ncbi Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population
    Heon Jeong Lee
    Department of Psychiatry, Korea University College of Medicine, Anam Hospital, 126 1, 5 Ka, Anam Dong, Sungbuk Ku, Seoul 136 705, Korea
    Am J Med Genet B Neuropsychiatr Genet 118:76-80. 2003
    ..When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and -521 C/T, there was no direct correlation with the personality traits...
  88. ncbi Wavelet-aided parametric mapping of cerebral dopamine D2 receptors using the high affinity PET radioligand [11C]FLB 457
    Zsolt Cselényi
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Neuroimage 17:47-60. 2002
    ..Such maps can be used for in inter-individual or multi-condition comparisons of binding parameters at subregional levels...
  89. ncbi Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample
    J Mill
    Social, Genetic, and Development Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Mol Psychiatry 6:440-4. 2001
    ..We conclude that the case-control findings are likely to be falsely positive, resulting from genetic stratification. However we can not rule out alternative explanations of low statistical power and gene-environment correlation...
  90. ncbi Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits
    H Mitsuyasu
    Division of Disease Genes, Institute of Genetic Information, Kyushu University, Fukuoka, Japan
    J Hum Genet 46:26-31. 2001
    ..044), while no significant association was observed between novelty seeking and polymorphisms in the upstream region or the exon III repeat polymorphism of the DRD4 gene...
  91. ncbi Novel regulation of p38gamma by dopamine D2 receptors during hypoxia
    P W Conrad
    College of Medicine, Department of Molecular and Cellular Physiology, University of Cincinnati, P O Box 67 0576, Cincinnati, OH 45267 0576, USA
    Cell Signal 12:463-7. 2000
    ..These results are the first to demonstrate that p38gamma can be regulated by the D2 receptor and calcium following hypoxic exposure...
  92. ncbi PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 9:1050-6. 2006
    ..Individual differences in the rate of recovery of D2 receptor function during abstinence were noted...
  93. ncbi Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking
    T Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Anagawa 4-Chome, Inage-ku, Chiba, 263-8555, Japan
    Neuroimage 13:891-5. 2001
    ..We measured extrastriatal dopamine D2 receptors of 24 healthy young male subjects using [(11)C]FLB 457 positron emission tomography...
  94. doi The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics
    Romina Mizrahi
    Centre for Addiction and Mental Health, PET Centre, Toronto, ON, Canada
    Int J Neuropsychopharmacol 12:715-21. 2009
    ..90 (S.D.=15.33), an effect that was sustained for 6 months. This sustained improvement was observed despite very high levels of DA D2 occupancy (82-99%), in contrast to the effects of antagonist antipsychotics on subjective well-being...
  95. ncbi Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase
    David M Mottola
    Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    J Pharmacol Exp Ther 301:1166-78. 2002
    ....
  96. ncbi Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors
    J Ahveninen
    Cognitive Brain Research Unit, Department of Psychology, PO Box 13, FIN 00014 University of Helsinki, Helsinki, Finland
    Neurosci Lett 292:29-32. 2000
    ..The present result suggests that dopamine D(2) receptors modulate selective attention...
  97. ncbi Dopamine D2 receptors and transporters in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland
    Hum Brain Mapp 20:91-102. 2003
    ..Moreover, WHA provides a useful tool for detailed mapping of neuronal receptors in healthy as well as diseased brain, and can also be used in radioligand development for PET...
  98. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
    ..The aim of this study was to compare activation of dopamine D2 receptors after amphetamine administration in the functional subdivisions of the human striatum...
  99. ncbi Downregulation of striatal dopamine D2 receptors in advanced Parkinson's disease contributes to the development of motor fluctuation
    Wen Jun Hwang
    Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Eur Neurol 47:113-7. 2002
    ..57 +/- 0.20 vs. 1.77 +/- 0.10, p = 0.024). We conclude that the decreased D2 receptor densities in advanced PD reduced the 'safety factor' for synaptic transmission and contributed to the development of motor fluctuation...
  100. ncbi Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease
    J C H van Oostrom
    Department of Neurology, Groningen University Medical Center, Groningen, The Netherlands
    Neurology 65:941-3. 2005
    ..0005). Dopamine D2 receptor availability measured by RAC-BP seems the most sensitive indicator of early neuronal impairment in PMC...
  101. pmc Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors
    Kyu Seok Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    J Biol Chem 285:8905-17. 2010
    ..Together, our findings suggest that the interaction between the dopaminergic system and leptin signaling in hypothalamus is important in control of energy homeostasis...

Research Grants78

  1. Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling
    David P Siderovski; Fiscal Year: 2010
    ....
  2. Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling
    David P Siderovski; Fiscal Year: 2010
    ....
  3. Structural Determinants of Heterotrimeric G-protein Nucleotide Cycling
    DAVID SIDEROVSKI; Fiscal Year: 2009
    ....
  4. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
    ..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
  5. Antipsychotic Drugs and Maternal Behavior: A Preclinical Investigation
    Ming Li; Fiscal Year: 2007
    ..as the representative of atypical antipsychotic drugs) disrupts maternal behavior via the blocking of dopamine D2 receptors and/or 5-HT2A receptors...
  6. New Dopamine D1 Agonists as PET Imaging Agents
    ONOFRE DEJESUS; Fiscal Year: 2007
    ..While PET imaging agents targeted to dopamine D2 receptors are well developed, the same can not be said for dopamine D1 PET imaging agents...
  7. Amphetamine sensitization in a model of schizophrenia
    Russell Brown; Fiscal Year: 2006
    ....
  8. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2010
    ..This research studies the neurobiological mechanisms underlying sensitization in brain dopamine D2 receptors that would exacerbate drug craving and relapse in cocaine users, and investigates novel approaches to ..
  9. Structure and function of dopamine receptors
    JONATHAN JAVITCH; Fiscal Year: 2009
    ....
  10. Molecular mechanisms of Vitex agnus-castus L. in PMS
    Zaijie Jim Wang; Fiscal Year: 2005
    ..Recent studies suggest that activation of dopamine D2 receptors and inhibition of prolactin release may account for part of the effect...
  11. Food reinforcement-genotype interactions and eating
    Leonard Epstein; Fiscal Year: 2009
    ..is mediated in part by the dopaminergic system, and research suggests obesity is related to the density of dopamine D2 receptors. In previous research we found smokers with high food reinforcement who had the A1 allele of the dopamine ..
  12. Food reinforcement-genotype interactions and eating
    Leonard Epstein; Fiscal Year: 2007
    ..is mediated in part by the dopaminergic system, and research suggests obesity is related to the density of dopamine D2 receptors. In previous research we found smokers with high food reinforcement who had the A1 allele of the dopamine ..
  13. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    Virginia M Pickel; Fiscal Year: 2010
    ....
  14. Dietary NMDA-based treatments for schizophrenia
    Michael Kaplowitz; Fiscal Year: 2005
    ..Development of D-serine and/or glycine will be conducted under FDA supervision, and will conform to all required FDA policies and procedures. ..
  15. Family Health After Predictive HD Testing
    Janet Williams; Fiscal Year: 2004
    ..study whose purpose is to determine the progressive changes in caudate and putamen volume, basal ganglia dopamine D2 receptors, and determine progressive cognitive and behavioral changes in persons with CAG expansions in the HD gene...
  16. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    VIRGINIA PICKEL; Fiscal Year: 2007
    ..and from animals receiving chronic treatment with haloperidol, a typical antipsychotic drug that blocks dopamine D2 receptors. Study I will test the hypotheses that (1) the levels of the vesicular monoamine transporter (VMAT2) and ..
  17. Cortical Mechanisms of Cocaine Sensitization
    Jeffery D Steketee; Fiscal Year: 2010
    ..Thus, the proposed studies are relevant in that an increased understanding of the mechanisms of sensitization might lead to improved treatment strategies for cocaine addiction. ..
  18. Ethanol regulation of signaling: from cells to behavior
    Ivan Diamond; Fiscal Year: 2009
    ..A2A receptors in the central nervous system (CNS) and is characterized by co-expression of A2A with dopamine D2 receptors (D2) on the same neurons...
  19. Cortical Mechanisms of Cocaine Sensitization
    JEFFERY STEKETEE; Fiscal Year: 2009
    ..Thus, the proposed studies are relevant in that an increased understanding of the mechanisms of sensitization might lead to improved treatment strategies for cocaine addiction. ..
  20. Maintenance Treatment for Smoking Cessation
    Joel Killen; Fiscal Year: 2004
    ....
  21. NEURONAL PLASTICITY IN THE RETINA
    Stuart C Mangel; Fiscal Year: 2010
    ..order cell that receives synaptic contact from cones, by controlling rod-cone gap junctional coupling via dopamine D2 receptors. Preliminary evidence suggests that the retinal clock also regulates rod and cone input to ganglion cells, ..
  22. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2009
    ..We have optimized 5- hydroxyaminotetralins for imaging dopamine D2 receptors which has resulted in the development of 18F-5- OH-FPPAT as a suitable imaging agent...
  23. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2007
    ..We have optimized 5- hydroxyaminotetralins for imaging dopamine D2 receptors which has resulted in the development of 18F-5- OH-FPPAT as a suitable imaging agent...
  24. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2009
    ..We have optimized 5- hydroxyaminotetralins for imaging dopamine D2 receptors which has resulted in the development of 18F-5- OH-FPPAT as a suitable imaging agent...