dopamine d2 receptors

Summary

Summary: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.

Top Publications

  1. ncbi Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 96:482-8. 2006
  2. pmc Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors
    Gemma Navarro
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain
    J Biol Chem 284:28058-68. 2009
  3. pmc Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    Paul M Johnson
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida, USA
    Nat Neurosci 13:635-41. 2010
  4. ncbi Distinct functions of the two isoforms of dopamine D2 receptors
    A Usiello
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, C U de Strasbourg, France
    Nature 408:199-203. 2000
  5. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
  6. ncbi Genetically determined differences in learning from errors
    Tilmann A Klein
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Science 318:1642-5. 2007
  7. ncbi Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1
    Matt J Neville
    Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, UK
    Hum Mutat 23:540-5. 2004
  8. ncbi Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics
    Terry Ritchie
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024 1759, USA
    Neurochem Res 28:73-82. 2003
  9. ncbi Striatal dopamine D2 receptors attenuate neuropathic hypersensitivity in the rat
    Osei B Ansah
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, University of Helsinki, 00014 Helsinki, Finland
    Exp Neurol 205:536-46. 2007
  10. ncbi Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization
    Taco J de Vries
    Research Institute Neurosciences Vrije Universiteit, Drug Abuse Program, Department of Medical Pharmacology, VU Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 26:18-26. 2002

Detail Information

Publications282 found, 100 shown here

  1. ncbi Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 96:482-8. 2006
    In the striatum, stimulation of dopamine D2 receptors results in attenuation of glutamate responses. This effect is exerted in large part via negative regulation of AMPA glutamate receptors...
  2. pmc Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors
    Gemma Navarro
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain
    J Biol Chem 284:28058-68. 2009
    ..These results may have implications for basal ganglia disorders, since A(2A)-D(2) receptor heteromers are being considered as a target for anti-parkinsonian agents...
  3. pmc Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
    Paul M Johnson
    Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Scripps Florida, Jupiter, Florida, USA
    Nat Neurosci 13:635-41. 2010
    ..Striatal dopamine D2 receptors (D2Rs) were downregulated in obese rats, as has been reported in humans addicted to drugs...
  4. ncbi Distinct functions of the two isoforms of dopamine D2 receptors
    A Usiello
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, C U de Strasbourg, France
    Nature 408:199-203. 2000
    Signalling through dopamine D2 receptors governs physiological functions related to locomotion, hormone production and drug abuse...
  5. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
    ....
  6. ncbi Genetically determined differences in learning from errors
    Tilmann A Klein
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Science 318:1642-5. 2007
    ..Dopamine D2 receptor reduction seems to decrease sensitivity to negative action consequences, which may explain an increased risk of developing addictive behaviors in A1-allele carriers...
  7. ncbi Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1
    Matt J Neville
    Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, UK
    Hum Mutat 23:540-5. 2004
    ..If this is the case, then changes in ANKK1 activity may provide an alternative explanation for previously described associations between the DRD2 Taq1A RFLP and neuropsychiatric disorders such as addiction...
  8. ncbi Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics
    Terry Ritchie
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024 1759, USA
    Neurochem Res 28:73-82. 2003
    ....
  9. ncbi Striatal dopamine D2 receptors attenuate neuropathic hypersensitivity in the rat
    Osei B Ansah
    Biomedicum Helsinki, Institute of Biomedicine Physiology, POB 63, University of Helsinki, 00014 Helsinki, Finland
    Exp Neurol 205:536-46. 2007
    ....
  10. ncbi Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization
    Taco J de Vries
    Research Institute Neurosciences Vrije Universiteit, Drug Abuse Program, Department of Medical Pharmacology, VU Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 26:18-26. 2002
    ..During early phases of withdrawal (<1 week), activation of dopamine D2 receptors with quinpirole resulted in robust, dose-dependent, reinstatement of (non-reinforced) responding in both ..
  11. pmc Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms
    Ahmed Hasbi
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Pharmacol 10:93-9. 2010
    ..These novel receptor heteromeric complexes, for the first time, establish the link between dopamine action and rapid calcium signaling...
  12. ncbi PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 9:1050-6. 2006
    ..Individual differences in the rate of recovery of D2 receptor function during abstinence were noted...
  13. ncbi Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..A consistent finding in drug-addicted subjects is a lower level of dopamine D2 receptors. In cocaine abusers, low levels of D2 receptors are associated with a lower level of metabolism in the ..
  14. pmc Dichotomous dopaminergic control of striatal synaptic plasticity
    Weixing Shen
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 321:848-51. 2008
    ..In models of Parkinson's disease, this system is thrown out of balance, leading to unidirectional changes in plasticity that could underlie network pathology and symptoms...
  15. ncbi Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, Children s Hospital and Regional Medical Center, Seattle, WA 98105 USA
    Neuron 42:653-63. 2004
    ..Thus, dopamine, by filtering less active inputs, appears to reinforce specific sets of corticostriatal synaptic connections...
  16. ncbi Half a century of antipsychotics and still a central role for dopamine D2 receptors
    Shitij Kapur
    Schizophrenia Program, CAMH, Toronto, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1081-90. 2003
    ..g., positive, negative, cognitive, and affective) that can be flexibly used and titrated in the service of patients' presenting psychopathology...
  17. ncbi Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization
    Yukihiko Iizuka
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1385, USA
    J Neurosci 27:12390-5. 2007
    ..Such an increase in DRD2 signaling relative to DRD1 would contribute to the imbalances in dopaminergic neurotransmission characteristic of schizophrenia...
  18. ncbi Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) with attention deficit hyperactivity disorder (ADHD)
    J T McCracken
    Department of Psychiatry and Biobehavioral Scienes, UCLA Neuropsychiatric Institute, Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA 90024 1759, USA
    Mol Psychiatry 5:531-6. 2000
    ..These data add further support for the role of DRD4 variants conferring increased risk for ADHD, and imply that additional studies of DRD4 and other related genes are needed...
  19. ncbi Dopamine modulates excitability of spiny neurons in the avian basal ganglia
    Long Ding
    Department of Zoology, University of Washington, Seattle, Washington 98195 6115, USA
    J Neurosci 22:5210-8. 2002
    ..The diversity of DA actions enables the DA system to fine-tune the dynamics of the song system and allows flexible control over song learning and production...
  20. ncbi Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor
    M Glass
    Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892 4090, USA
    J Neurosci 17:5327-33. 1997
    ..Within the striatum, CB1 receptors have been shown to be localized on the same neurons as Gi-coupled dopamine D2 receptors. In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase...
  21. ncbi Dopamine D2 receptors as treatment targets in schizophrenia
    Philip Seeman
    Pharmacology Department, Faculty of Medicine, University of Toronto, Canada
    Clin Schizophr Relat Psychoses 4:56-73. 2010
    ..Future goals include imaging D2High receptors and desensitizing them in early-stage psychosis...
  22. pmc Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor
    Frank J S Lee
    Department of Neuroscience, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    EMBO J 26:2127-36. 2007
    ..Our data highlight a novel mechanism through which neurotransmitter receptors can functionally modulate neurotransmitter transporters, an interaction that can affect the synaptic neurotransmitter levels in the brain...
  23. ncbi D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA lt j
    Trends Neurosci 30:228-35. 2007
    ..These studies have also shown that long-term alterations in dopamine signaling produce profound and cell-type-specific reshaping of corticostriatal connectivity and function...
  24. ncbi Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants
    V Asghari
    Department of Psychiatry, University of Toronto, Ontario, Canada
    J Neurochem 65:1157-65. 1995
    ..The data presented indicate that the polymorphic repeat sequence causes only small changes in the ability of the D4 receptor to block cAMP production in CHO cells...
  25. ncbi Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]raclopride
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
    Biol Psychiatry 58:908-12. 2005
    ..Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN)...
  26. ncbi Effects of dopaminergic and serotonergic manipulation on emotional processing: a pharmacological fMRI study
    Hidehiko Takahashi
    Brain Imaging Project, National Institute of Radiological Sciences, Japan
    Neuroimage 27:991-1001. 2005
    ..At the same time, our findings suggest that pharmacological fMRI could be a powerful tool for investigating the neurophysiological properties of drugs targeting neuropsychiatric disorders...
  27. ncbi Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
    H H Van Tol
    Department of Pharmacology, University of Toronto, Ontario, Canada
    Nature 350:610-4. 1991
    ..Recognition and characterization of this clozapine neuroleptic site may prove useful in the design of new types of drugs...
  28. ncbi Dopamine modulates release from corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, USA
    J Neurosci 24:9541-52. 2004
    ..Microdialysis revealed that basal extracellular striatal glutamate was normal in DD mice. These data indicate that dopamine deficiency results in morphologically normal corticostriatal terminals with hypersensitive D2 receptors...
  29. ncbi Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking
    R P Ebstein
    Research Laboratory, S Herzog Memorial Hospital, Jerusalem, Israel
    Nat Genet 12:78-80. 1996
  30. ncbi The role of dopamine receptors in regulating the size of axonal arbors
    C L Parish
    Neurosciences Group, Department of Medicine and Department of Neurology, Monash Medical Center, Clayton 3168, Australia
    J Neurosci 21:5147-57. 2001
    ..These results suggest that individual dopaminergic axons in D2(-/-) mice have reached maximal arbor size. We conclude that the D2 receptor may play a role in modulating the extent of the terminal arbor of SNpc neurons...
  31. pmc Dopamine D2 receptors form higher order oligomers at physiological expression levels
    Wen Guo
    Center for Molecular Recognition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    EMBO J 27:2293-304. 2008
    ..bioluminescence/fluorescence complementation and energy transfer to demonstrate that at least four dopamine D2 receptors are located in close molecular proximity in living mammalian cells, consistent with their organization as ..
  32. ncbi Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers
    Mitul A Mehta
    Department of Psychiatry, Level E4, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 176:331-42. 2004
    ..These include working memory and set-shifting deficits. Theories of DA function have predicted that distraction or impaired switching may be important determinants of such deficits...
  33. pmc Activation of ATP-sensitive K+ (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release
    Marat V Avshalumov
    Department of Physiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:11729-34. 2003
    ..These data not only demonstrate that KATP channels can modulate CNS transmitter release in response to fast-synaptic transmission but also introduce H2O2 as a KATP-channel regulator...
  34. ncbi Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population
    Elitza T Betcheva
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Tokyo, Japan
    J Hum Genet 54:98-107. 2009
    ..Our findings support one of the most widely considered hypotheses for schizophrenia etiology, the dopaminergic hypothesis...
  35. ncbi L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    M A Cenci
    Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
    Eur J Neurosci 10:2694-706. 1998
    ..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
  36. pmc Role of dysbindin in dopamine receptor trafficking and cortical GABA function
    Yuanyuan Ji
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:19593-8. 2009
    ..Taken together, these results suggest that dysbindin regulates PFC function by facilitating D2-mediated modulation of GABAergic function...
  37. ncbi Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 38:291-303. 2003
    ..The present study indicates that postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity...
  38. pmc Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia
    Alessandro Bertolino
    Department of Neurology and Psychiatry, University of Bari, Bari, Italy
    Brain 132:417-25. 2009
    ..Our results indicate that the three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 density...
  39. ncbi Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
    J H Baik
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Nature 377:424-8. 1995
    ..Here we have studied the physiological involvement of the dopamine D2 receptors in dopaminergic transmission, using homologous recombination to generate D2-receptor-deficient mice...
  40. ncbi Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias
    M R Munafò
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    Mol Psychiatry 12:454-61. 2007
    ....
  41. ncbi Cloning and expression of a rat D2 dopamine receptor cDNA
    J R Bunzow
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    Nature 336:783-7. 1988
    ....
  42. ncbi Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder
    G J LaHoste
    Department of Physical Medicine and Rehabilitation, University of California, Irvine 92717 4550, USA
    Mol Psychiatry 1:121-4. 1996
    ....
  43. ncbi Functional selectivity and classical concepts of quantitative pharmacology
    Jonathan D Urban
    Curriculum in Toxicology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    J Pharmacol Exp Ther 320:1-13. 2007
    ..It also may be timely to revise classic concepts in quantitative pharmacology and relevant pharmacological conventions to incorporate these new concepts...
  44. ncbi Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors
    P Calabresi
    Clinica Neurologica, Universita di Roma Tor Vergata, Dipartimento Sanita, 00173 Rome, Italy
    J Neurosci 17:4536-44. 1997
    b>Dopamine D2 receptors (D2Rs) are of crucial importance in the striatal processing of motor information received from the cortex. Disruption of the D2R gene function in mice results in a severe locomotor impairment...
  45. ncbi Altered dopamine release and uptake kinetics in mice lacking D2 receptors
    Yvonne Schmitz
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:8002-9. 2002
    ..These results from D2-null mutant mice support the suggestion that D2 autoreceptors and dopamine transporters interact to regulate the amplitude and timing of dopamine signals...
  46. ncbi Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents
    S M Hersch
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 15:5222-37. 1995
    ..These findings demonstrate differential patterns of expression of D1 and D2 receptors in striatal neurons and axon terminals and their differential involvement in motor corticostriatal circuits...
  47. pmc Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biol Psychiatry 65:1024-31. 2009
    ..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
  48. ncbi Striatal dopamine D1 and D2 receptors in burning mouth syndrome
    Nora Hagelberg
    Department of Anesthesiology and Intensive Care, Turku University Central Hospital, PO Box 52, FIN 20521, Turku, Finland
    Pain 101:149-54. 2003
    ..65+/-0.05 vs. 0.70+/-0.05, P=0.05) when compared to controls. Increased 11C-raclopride uptake and the subsequent decrease in the D1/D2 ratio may indicate a decline in endogenous dopamine levels in the putamen in burning mouth patients...
  49. ncbi Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits
    H Mitsuyasu
    Division of Disease Genes, Institute of Genetic Information, Kyushu University, Fukuoka, Japan
    J Hum Genet 46:26-31. 2001
    ..044), while no significant association was observed between novelty seeking and polymorphisms in the upstream region or the exon III repeat polymorphism of the DRD4 gene...
  50. ncbi The role of dopamine in motivation for food in humans: implications for obesity
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Expert Opin Ther Targets 6:601-9. 2002
    ..A better understanding of the role of the DA system in the motivation for food intake will help the development of better therapeutic interventions...
  51. ncbi D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism
    Elizabeth A Bolan
    Integrative Neuroscience Section, National Institute on Drug Abuse Intramural Research Program National Institutes of Health Department of Health and Human Services, Baltimore, MD 21224, USA
    Mol Pharmacol 71:1222-32. 2007
    ..Our data also suggest the possibility of a direct physical interaction between DAT and D(2)R. Together, these results suggest a novel mechanism by which D(2S)R autoreceptors may regulate DAT in the central nervous system...
  52. pmc Functional coupling of the human dopamine D2 receptor with G alpha i1, G alpha i2, G alpha i3 and G alpha o G proteins: evidence for agonist regulation of G protein selectivity
    Lucien Gazi
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, RG6 6AJ
    Br J Pharmacol 138:775-86. 2003
    ..5) We conclude that the degree of selectivity of G protein activation by the D(2L) receptor can depend on the conformation of the receptor stabilised by an agonist...
  53. ncbi Involvement of dopamine D2 receptors in apomorphine-induced facilitation of forebrain serotonin output
    A Mendlin
    Program in Neuroscience, Princeton University, NJ 08544 1010, USA
    Eur J Pharmacol 351:291-8. 1998
    ..This indicates that dopamine D2 receptors, and not 5-HT1A receptors, mediate the facilitatory effect of apomorphine, and that this effect occurs at ..
  54. ncbi Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women
    Petra Kok
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 291:E1038-43. 2006
    ..Thus these results imply that short-term bromocriptine treatment ameliorates various components of the metabolic syndrome while it shifts energy balance away from lipogenesis in obese humans...
  55. ncbi PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation
    Michael A Nader
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Psychiatry 162:1473-82. 2005
    ....
  56. ncbi The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects
    Aki Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku University Central Hospital, Turku, Finland
    Pharmacogenet Genomics 15:387-91. 2005
    ..The finding can be explained by lower D2 receptor expression leading to decreased autoreceptor function, and suggests that dopamine and/or trace amine synthesis rate is increased in the brains of A1 allele carriers...
  57. ncbi Striatal dopamine D2 receptors in modulation of pain in humans: a review
    Nora Hagelberg
    Turku PET Centre, Turku University Central Hospital and University of Turku, 20520 Turku, Finland
    Eur J Pharmacol 500:187-92. 2004
    We review evidence indicating that the striatum and striatal dopamine D2 receptors are involved in the regulation of pain in humans. Painful stimulation produces an increase in regional cerebral blood flow in the human striatum...
  58. ncbi Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse
    Christoph Fehr
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    Am J Psychiatry 165:507-14. 2008
    ..However, it is unclear whether similar changes can also be observed in heavy-smoking nicotine-dependent smokers...
  59. ncbi Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 166:1056-67. 2010
    ..These findings may have implications for the treatment of psychiatric symptoms such as psychomotor slowing, anergia and fatigue...
  60. ncbi Imaging extrastriatal dopamine D(2) receptor occupancy by endogenous dopamine in healthy humans
    M Fujita
    Department of Psychiatry, Yale University, VA Connecticut, West Haven, CT 06516, USA
    Eur J Pharmacol 387:179-88. 2000
    ..88, P=0.004). These results imply that [123I]epidepride, coupled with acute dopamine depletion might provide estimates of synaptic dopamine concentration...
  61. ncbi Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5
    V Kustanovich
    Department of Human Genetics, Division of Child and Adolescent Psychiatry, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Mol Psychiatry 9:711-7. 2004
    ..240) allele of the promoter polymorphism emerge as the two DNA variants showing a significant association in this large sample of predominantly multiplex families with ADHD, with estimated GRRs of 1.7 and 1.37, respectively...
  62. pmc Getting specialized: presynaptic and postsynaptic dopamine D2 receptors
    Claudia De Mei
    University of California Irvine, Department of Microbiology and Molecular Genetics, 3113 Gillespie NRF, Irvine, CA 92617 USA
    Curr Opin Pharmacol 9:53-8. 2009
    ..Recent results from knockout mice are clarifying the role of site and D2 isoform-specific effects thereby increasing our understanding of how DA modulates neuronal physiology...
  63. ncbi D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain
    Y L Hurd
    Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, SE 171 76, Stockholm, Sweden
    J Chem Neuroanat 22:127-37. 2001
    ..The restricted expression of the D1 mRNA to the cortical mantle and to a few forebrain structures indicates a strong involvement of the D1 system in cognitive function...
  64. ncbi Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminals
    M Ennis
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurophysiol 86:2986-97. 2001
    ..DA and D2 agonists had no effect in D2 receptor knockout mice, suggesting that D2 receptors are the only type of DA receptors that affect signal transmission from the ON to the rodent olfactory bulb...
  65. ncbi Effects of selective dopamine D1 or D2 receptor blockade within nucleus accumbens subregions on ingestive behavior and associated motor activity
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
    Behav Brain Res 137:165-77. 2002
    ..These results are discussed with regard to current theories of dopaminergic control of feeding behavior, and with reference to the functional heterogeneity of Acb subregions...
  66. ncbi Opposing roles of D1 and D2 receptors in appetitive conditioning
    Yaniv S Eyny
    Department of Psychology and Program in Neurobiology and Behavior, Columbia University, New York, New York 10027, USA
    J Neurosci 23:1584-7. 2003
    ....
  67. ncbi Further evidence for a modulation of Novelty Seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants
    A Strobel
    Mol Psychiatry 8:371-2. 2003
  68. ncbi Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors
    B A Cox
    Medical Research Service, Veterans Affairs Medical Center, Portland, Oregon 97207
    J Neurochem 59:627-35. 1992
    ....
  69. pmc The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus
    E Wang
    Department of Biological Chemistry, University of California at Irvine, Irvine, CA 92697, USA
    Am J Hum Genet 74:931-44. 2004
    ..We propose a model for selection at the DRD4 locus consistent with these observed LD patterns and with the known biochemical and physiological differences between receptor variants...
  70. ncbi Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457
    Sargo Aalto
    Turku PET Centre, University of Turku, FIN 20014 Turku, Finland
    J Neurosci 25:2471-7. 2005
    ..Our results indicate that regionally specific components of the frontotemporal dopaminergic network are functionally involved in WM performance in humans...
  71. pmc Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling
    Henry H Yin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:8251-6. 2006
    ..These results demonstrate a previously unrecognized role for retrograde eCB signaling in reversible and frequency-specific inhibition of glutamate release by the activation of striatal D2Rs...
  72. ncbi Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Mol Psychiatry 4:290-6. 1999
    The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects. This variability might be due to genetic or environmental factors...
  73. ncbi Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y, USA
    Am J Psychiatry 156:1440-3. 1999
    ..This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans...
  74. ncbi Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
    Joelle Hillion
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    J Biol Chem 277:18091-7. 2002
    ..These results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D(2)R are involved...
  75. ncbi Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4)
    M I Seaman
    Department of Anthropology, Yale University, New Haven, Connecticut 06520 8005, USA
    Am J Med Genet 88:705-9. 1999
    ..The frequency of this derived duplication allele ranges from 0.40-0.81 in the 11 populations from around the world typed for this polymorphism. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:705-709, 1999...
  76. ncbi Activation of dopamine D2 receptors lowers circadian leptin concentrations in obese women
    Petra Kok
    Department of Internal Medicine C4 83, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 91:3236-40. 2006
    ..This study was done to establish the effect of bromocriptine treatment on circadian plasma leptin concentrations in obese humans...
  77. ncbi A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission
    Suhas A Kotecha
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Neuron 35:1111-22. 2002
    ....
  78. ncbi The dopaminergic innervation of the avian telencephalon
    D Durstewitz
    AE Biopsychologie, Ruhr Universitat Bochum, Germany
    Prog Neurobiol 59:161-95. 1999
    ..Thus, despite considerable differences in the anatomical organization of the avian and mammalian forebrain, the organization of the dopaminergic system and its behavioral functions are very similar in birds and mammals...
  79. ncbi Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice
    M A Kelly
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Neuron 19:103-13. 1997
    ....
  80. ncbi Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning
    Christoph Kellendonk
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Neuron 49:603-15. 2006
    ..We found that D2R overexpression in the striatum impacts dopamine levels, rates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are critical for working memory...
  81. ncbi Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 5:169-74. 2002
    ..monkeys did not differ during individual housing, social housing increased the amount or availability of dopamine D2 receptors in dominant monkeys and produced no change in subordinate monkeys...
  82. ncbi Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity
    Xu Feng Huang
    Department of Biomedical Science, University of Wollongong, NSW 2522, Australia
    Behav Brain Res 175:415-9. 2006
    ..D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice...
  83. ncbi Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5
    K Ito
    Department of Neurochemistry, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 260:112-9. 1999
    ..D2S receptors expressed in HEK 293 cells were shown to be phosphorylated by GRK2 in an agonist-dependent manner. These results indicate that the sequestration of D2 receptors occurs only through a GRK-mediated pathway...
  84. ncbi Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:447-61. 2009
    ..These findings suggest that [(11)C]FLB 457 is superior to [(11)C]fallypride for measurement of changes in cortical synaptic dopamine...
  85. ncbi Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons
    J K Seamans
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 21:3628-38. 2001
    ..This bidirectional modulation could have important implications for the computational properties of active PFC networks...
  86. ncbi Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia
    S J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, MA 02115, USA
    Mol Psychiatry 8:911-5. 2003
    ..Although more family-based studies are needed to confirm this relation, our results provide strong evidence that DRD2 influences susceptibility to schizophrenia...
  87. ncbi Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding
    Simon Cervenka
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Brain 129:2017-28. 2006
    ..The results do not support variations in dopamine D2-receptor availability as a correlate to the diurnal rhythm of RLS symptoms...
  88. ncbi DRD4 and novelty seeking: results of meta-analyses
    J A Schinka
    James A Haley Veteran Administration Medical Center, Tampa, Florida 33612, USA
    Am J Med Genet 114:643-8. 2002
    ..32. The positive findings are consistent with a polygenic model of influence on fundamental personality dimensions...
  89. ncbi A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 29:1488-97. 2004
    ..Understanding the molecular and physiological effects of drugs of abuse in the brain is essential for the development of effective strategies against addiction...
  90. ncbi Association of dopamine D3-receptor gene variants with neuroleptic induced akathisia in schizophrenic patients: a generalization of Steen's study on DRD3 and tardive dyskinesia
    P Eichhammer
    Department of Psychiatry, University of Regensburg, Regensburg, Germany
    Am J Med Genet 96:187-91. 2000
    ..9% incidence of AA in schizophrenic patients nonhomozygous for the 2-2 allele (exact P = 0.0223). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:187-191, 2000...
  91. pmc Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function
    Carla Ferrada
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, University of Barcelona, 08028 Barcelona, Spain
    Neuropharmacology 55:190-7. 2008
    ..This study demonstrates an important role of postsynaptic H(3) receptors in the modulation of dopaminergic transmission by means of a negative modulation of D(2) receptor function...
  92. pmc Induction of striatal long-term synaptic depression by moderate frequency activation of cortical afferents in rat
    Jennifer Ronesi
    Laboratory for Integrative Neuroscience, National Institute of Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA
    J Physiol 562:245-56. 2005
    ..Our results demonstrate that a prolonged moderate frequency train induces cannabinoid-dependent LTD, further supporting the idea that endocannabinoids play a prominent role in the regulation of long-lasting changes in striatal output...
  93. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D(2) receptor parameter measurements in ventral striatum
    O Mawlawi
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Cereb Blood Flow Metab 21:1034-57. 2001
    ....
  94. ncbi Reduced striatal D2 receptor binding in myoclonus-dystonia
    R J Beukers
    Department of Neurology, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:269-74. 2009
    ..To study striatal dopamine D(2) receptor availability in DYT11 mutation carriers of the autosomal dominantly inherited disorder myoclonus-dystonia (M-D)...
  95. ncbi DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients
    Todd Lencz
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:529-31. 2006
    ....
  96. ncbi 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation
    S Kapur
    Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, Ont, Canada
    Am J Psychiatry 155:921-8. 1998
    ..The purpose of this study was to investigate olanzapine's binding to the serotonin 5-HT2 and dopamine D2 receptors in schizophrenic patients being treated with clinically relevant doses.
  97. ncbi Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models
    Sridhar Natesan
    Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 31:1854-63. 2006
    ..Partial agonism of aripiprazole offers a good explanation for this dissociation and provides a framework for understanding occupancy-functional relationships of partial D2 agonist antipsychotics...
  98. pmc Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors
    Kyu Seok Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    J Biol Chem 285:8905-17. 2010
    ..Together, our findings suggest that the interaction between the dopaminergic system and leptin signaling in hypothalamus is important in control of energy homeostasis...
  99. pmc Increased baseline occupancy of D2 receptors by dopamine in schizophrenia
    A Abi-Dargham
    Departments of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 97:8104-9. 2000
    ..This finding provides direct evidence of increased stimulation of D(2) receptors by dopamine in schizophrenia, consistent with increased phasic activity of dopaminergic neurons...
  100. ncbi Differential glycosylation and intracellular trafficking for the long and short isoforms of the D2 dopamine receptor
    C S Fishburn
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 270:29819-24. 1995
    ..These results give rise to the suggestion that the difference observed between the two alternatively spliced isoforms of the D2 receptor may lie in their post-translational processing and intracellular trafficking...
  101. ncbi Contribution of serine residues to constitutive and agonist-induced signaling via the D2S dopamine receptor: evidence for multiple, agonist-specific active conformations
    B L Wiens
    Medical Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Mol Pharmacol 54:435-44. 1998
    b>Dopamine D2 receptors contain a cluster of serine residues in the fifth transmembrane domain that contribute to activation of the receptor as well as to the binding of agonists...

Research Grants65

  1. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ....
  2. Early social stress, novelty seeking, and impulsive behavior
    David M Lyons; Fiscal Year: 2013
    ..Consequently, there is an urgent need for new mechanistic insights to guide the development of public health policies and interventions designed to alleviate the detrimental long-term effects of exposure to early social stress. ..
  3. Dopamine D1 Receptor in mouse models of primary dystonia
    Laurie J Ozelius; Fiscal Year: 2013
    ..Identification of a final common pathway in different forms of EOTD will aid in directing discovery of therapeutic targets for this currently incurable disorder. ..
  4. Regulation of Brain Signaling After Bariatric Surgery
    Jonathan Q Purnell; Fiscal Year: 2010
    ..abstract_text> ..
  5. Long-Term Safety and Genetic Risk Factors of Risperdone Treatment in Youth
    Chadi A Calarge; Fiscal Year: 2010
    ....
  6. OXIDATIVE STRESS IN THE KIDNEY IN HYPERTENSION
    Christopher S Wilcox; Fiscal Year: 2013
    ..mechanisms of defense against oxidative stress in the proximal tubule that are coordinated by the dopamine D2 receptors. The new hypothesis is that D2-R signaling enhances paraoxygenase-2 which activates a transcriptional ..
  7. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2012
    ..This research studies the neurobiological mechanisms underlying sensitization in brain dopamine D2 receptors that would exacerbate drug craving and relapse in cocaine users, and investigates novel approaches to ..
  8. Novel tools for identifying GPCR compounds modulating specific sub-cellular ERK a
    Haifeng Eishingdrelo; Fiscal Year: 2013
    ..Aim 3. Generate and characterize D2R ERK pathway-selective activation assay cells. Dopamine D2 receptors (D2R) include a long (D2L) and a short (D2S) isoforms...
  9. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2013
    ..Furthermore, exogenous GDNF administration will alleviate the dopaminergic damage associated with increased glutamate toxicity as a result of a life-long reduction of GDNF. ..
  10. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2010
    ..Furthermore, exogenous GDNF administration will alleviate the dopaminergic damage associated with increased glutamate toxicity as a result of a life-long reduction of GDNF. ..
  11. Nicotine and the roles of nicotinic receptors in a rodent model of schizophrenia
    Russell W Brown; Fiscal Year: 2013
    ..The critical hypothesis tested is that adult rats neonatally treated with quinpirole wil self-administer more nicotine than animals neonatally treated with saline. ..
  12. DBH, D2High and Cocaine Paranoia/Aversion: A [11C]PHNO PET Study
    Robert T Malison; Fiscal Year: 2010
    ..Thus, the identification of genetic and/or neurobiologic mechanisms underlying cocaine aversion may provide insights into addiction susceptibility, and in turn, improved treatment and/or prevention efforts. ..
  13. Alcoholism and Schizophrenia: A Translational Approach to Treatment
    Alan I Green; Fiscal Year: 2012
    ..Finding medications that may be able to limit alcohol use and thereby reduce adverse outcomes in patients with schizophrenia is of great public health importance. ..
  14. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    Virginia M Pickel; Fiscal Year: 2013
    ..The results will have many important implications for understanding the cross-sensitization between opiates and cannabinoids and for devising new treatments for addictive diseases. ..
  15. fMRI of Cholinergic Mechanisms in Schizophrenia
    Jason R Tregellas; Fiscal Year: 2013
    ....
  16. Cell-specific translational profiling in Huntington's Disease mouse models
    ROBERT JONATHAN FENSTER; Fiscal Year: 2012
    ..the distinct population of striatopallidal neurons, which project to the globus pallidum externa, express dopamine D2 receptors (Drd2s) and inhibit voluntary movement, dies before striatonigral neurons, which project to the substantia ..
  17. Relating GPCRs by biased ligands for enhanced therapeutic efficacy
    MICHAEL JAMES KEISER; Fiscal Year: 2013
    ..Whereas these goals are admittedly ambitious, preliminary results suggest that they are feasible. ..
  18. Biased Attention to Emotional Faces as an Endophenotype Predicting Depression
    JESSICA LYNNE JENNESS; Fiscal Year: 2013
    ..The research will test clear a priori hypotheses about the developmental pathways through which candidate genes may influence depression. ..
  19. Behavioral Genetics of Mood-Induced Smoking
    KENNETH ALAN PERKINS; Fiscal Year: 2010
    ..Results may guide research on genetics of environmental influences on smoking behavior and other drug abuse, and perhaps guide research on the mechanisms behind mood-induced smoking. ..
  20. Functional Selectivity: A Novel approach for CNS Drug Discovery
    Bryan L Roth; Fiscal Year: 2013
    ..three main projects: Project #1: Will deliver beta-arrestin-biased agonist clinical candidates of dopamine D2 receptors (D2R) for the treatment of schizophrenia and related disorders, and create novel D2R ligands with a wide ..
  21. Probing dopamine D2 receptor trafficking in schizophrenia
    Anissa Abi-Dargham; Fiscal Year: 2013
    ..striatum of patients with schizophrenia but we know little about the underlying mechanistic involvement of dopamine D2 receptors (D2R) in the illness...
  22. Preweanling Methylphenidate Exposure and Reward Behavior
    Cynthia Crawford; Fiscal Year: 2009
    ..In the third set of experiments, we will examine changes in the number and functioning of dopamine D2 receptors after preweanling methylphenidate exposure...
  23. Glutamate-Dopamine Plasticity in Nigrostriatal Injury: Excerise Enhanced Recovery
    John P Walsh; Fiscal Year: 2010
    ..Mice will either be administered MPTP or saline and a subset from each group subjected to intensive treadmill exercise for 28 days. This proposal consists of two specific aims. ..
  24. Cortical Mechanisms of Cocaine Sensitization
    Jeffery D Steketee; Fiscal Year: 2012
    ..Thus, the proposed studies are relevant in that an increased understanding of the mechanisms of sensitization might lead to improved treatment strategies for cocaine addiction. ..
  25. Dopamine D2 Receptors in Prefrontal Function: An Optogenetic and Modeling Study
    IAN THOMAS ELLWOOD; Fiscal Year: 2013
    ..In addition, this model may be used to gain insight into perturbations of normal D2R function that have been hypothesized to underlie psychiatric diseases such as schizophrenia. ..
  26. Gene x Environment Interactions Predicting an Endophenotype for Depression
    Caroline Oppenheimer; Fiscal Year: 2012
    ..The research will test clear a priori hypotheses about the developmental pathways through which these candidate genes may influence depression. ..
  27. Development of PET tracers for in vivo quantification of PDE10A
    MAJO VATTOLY JOSEPH; Fiscal Year: 2013
    ..Thus, the successful tracer will both inform about pathophysiology and facilitate development of PDE10A inhibitors in psychosis and cognitive disorders. ..
  28. Amphetamine sensitization in a model of schizophrenia
    Russell W Brown; Fiscal Year: 2010
    ..abstract_text> ..
  29. NEURONAL PLASTICITY IN THE RETINA
    Stuart C Mangel; Fiscal Year: 2012
    ..order cell that receives synaptic contact from cones, by controlling rod- cone gap junctional coupling via dopamine D2 receptors. Preliminary evidence suggests that the retinal clock also regulates rod and cone input to ganglion cells, ..
  30. Role of Dopamine D2 Receptor in Renal Inflammation and Injury
    Ines Armando; Fiscal Year: 2013
    ..These results could then be critical for designing innovative genetic testing assays and therapeutics. ..
  31. Impact of In Utero Cocaine Exposure on Vulnerability to Drug Abuse in Monkeys.
    Michael A Nader; Fiscal Year: 2012
    ..These studies will further explore factors related to etiology and maintenance of drug abuse, which should aid in the development of novel treatment strategies. ..
  32. Presynaptic versus postsynaptic functions of dopamine D2 receptors in the respons
    Emiliana Borrelli; Fiscal Year: 2012
    ..of this proposal is to demonstrate that the presynaptic autoreceptor/heterosynaptic control mediated by dopamine D2 receptors exerts a principal role in the behavioral and cellular responses to drugs of abuse...
  33. Dopamine D2 receptor overexpression, adenosine A2A receptors, and motivation
    RYAN DAVID WARD; Fiscal Year: 2010
    ..Adenosine A2A receptors, which are coexpressed with dopamine D2 receptors on the same population of striatal neurons, modulate effort related choice by means of a reciprocal ..
  34. DOPAMINE D2 RECEPTORS IN PRIMATE MODELS OF COCAINE ABUSE
    Michael A Nader; Fiscal Year: 2012
    ....
  35. Medium Spiny Neuron Excitability and Motivation
    Christoph Kellendonk; Fiscal Year: 2013
    ....
  36. TESTING THE PHASIC DOPAMINE RELEASE HYPOTHESIS IN TOURETTE SYNDROME: PILOT
    TAMARA G HERSHEY; Fiscal Year: 2013
    ..The planned R01-funded follow-up study would include sample sizes adequate to test the effects of psychiatric comorbidity, past treatment, and demographic variables. ..
  37. Dopamine Neurobiology in HIV-Associated Cognitive Dysfunction and Substance Use
    Michelle M Jacobs; Fiscal Year: 2013
    ..Together, this project will allow an in-depth study into both dopaminergic dysfunction as well as the underlying neuropathogenesis affected by both HIV and substance use. ..
  38. Supersensitive dopamine D2 receptor inhibition of the striatopallidal projection
    Fu Ming Zhou; Fiscal Year: 2013
    ..If proven, this is a new mechanism that can compensate for the loss of dopamine in PD, and the presynaptic D2Rs on the striatopallidal axon terminals may also be a target of the dopaminergic treatments for PD. ..
  39. Synthetic-Collimator SPECT with Semiconductor Detectors
    Todd E Peterson; Fiscal Year: 2013
    ..Overall, on a per detector-area basis this approach should provide a unique combination of spatial resolution and sensitivity for preclinical SPECT imaging studies. ..
  40. Reverse engineering the prefrontal microcircuit
    VIKAAS SINGH SOHAL; Fiscal Year: 2012
    ..b>Dopamine D2 receptors are only expressed in one of these subtypes, and we will test the hypothesis that D2 receptor activation ..
  41. Imaging Biomarkers of Neurotoxicity in Welders
    Brad A Racette; Fiscal Year: 2013
    ..The methods described in this application represent cutting edge molecular and MRI techniques and the institutions and investigators are ideally suited for this unique epidemiology and imaging proposal. ..
  42. Evaluating BMY-14802 as an anti-dyskinesia treatment in the 6-OHDA rat model of P
    MELANIE PAQUETTE; Fiscal Year: 2009
    ....
  43. Molecular biology of mesocortical and mesoaccumbens dopamine neurons
    JEFFREY EELLS; Fiscal Year: 2009
    ....
  44. Nicotinic Receptors and Schizophrenia
    Robert Freedman; Fiscal Year: 2013
    ..The hypothesis to be tested in the proposed renewal is that DMXB-A will produce significant neurocognitive improvement in Veterans with schizophrenia. ..
  45. Function and Dysfunction of LRRK2
    Jie Shen; Fiscal Year: 2013
    ..Our long-term goal is to understand the pathogenic mechanism underlying dopaminergic dysfunction and degeneration, and to characterize the cellular and molecular pathways responsible for PD pathogenesis. ..
  46. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
    ..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
  47. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..We have optimized 5- hydroxyaminotetralins for imaging dopamine D2 receptors which has resulted in the development of 18F-5- OH-FPPAT as a suitable imaging agent...
  48. Drugs of abuse, Dopamine and the Circadian Clock: a Metabolomic Study
    Paolo Sassone-Corsi; Fiscal Year: 2013
    ..The outcome of the proposed research will develop in future directions including a comparative metabolome analysis of various drugs of abuse in various animal models. ..
  49. GENETIC STUDY OF AUTISTIC CHILDREN AND ADOLESCENTS
    Edwin Cook; Fiscal Year: 1999
    ..The statistical methods have been chosen to reduce the change of a false positive result due to population stratification. ..
  50. BASAL GANGLIA GENE EXPRESSION AND MOVEMENT DISORDERS
    Kalpana Merchant; Fiscal Year: 1993
    ..have been implicated in the etiology of these diseases since all clinically effective APDs appear to block dopamine D2 receptors. However, identification of APD's neuronal substrates postsynaptic to dopamine is necessary to gain an ..
  51. PERIPHERAL MARKERS OF STYRENE TOXICITY
    Harvey Checkoway; Fiscal Year: 1990
    ..The specific aims of this research are: 1) to compare levels of dopamine D2 receptors, monoamine oxidase type B and serotonin uptake in circulating platelets, leukocyte concentrations of ..
  52. POSITRON EMISSION TOMOGRAPHY INVESTIGATIONS OF DYSTONIA
    Joel Perlmutter; Fiscal Year: 1999
    ....
  53. Family Health After Predictive HD Testing
    Janet Williams; Fiscal Year: 2004
    ..study whose purpose is to determine the progressive changes in caudate and putamen volume, basal ganglia dopamine D2 receptors, and determine progressive cognitive and behavioral changes in persons with CAG expansions in the HD gene...
  54. IMAGING OF THE BRAIN USING SMALL GAMMA CAMERAS
    JOHN AARSVOLD; Fiscal Year: 2001
    ..To study these neuropsychiatric disorders and the related mechanisms of dopamine D2 receptors, several radioiodinated ligands have been developed...
  55. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    VIRGINIA PICKEL; Fiscal Year: 2007
    ..unreadable] Together, the results will contribute to our understanding of the[unreadable] pathophysiology and treatment of hyperkinetic movement disorders and[unreadable] schizophrenia. ..
  56. D2 RECEPTORS IN SCHIZOPHRENIA: OPTIMIZED PET LIGANDS
    Robert Kessler; Fiscal Year: 1993
    ....
  57. Dietary NMDA-based treatments for schizophrenia
    Michael Kaplowitz; Fiscal Year: 2005
    ..Development of D-serine and/or glycine will be conducted under FDA supervision, and will conform to all required FDA policies and procedures. ..
  58. Maintenance Treatment for Smoking Cessation
    Joel Killen; Fiscal Year: 2004
    ....
  59. Molecular mechanisms of Vitex agnus-castus L. in PMS
    Zaijie Jim Wang; Fiscal Year: 2005
    ..Recent studies suggest that activation of dopamine D2 receptors and inhibition of prolactin release may account for part of the effect...
  60. STATE OF THE ART PET SCANNER FOR MEDICAL RESEARCH
    Marc Laruelle; Fiscal Year: 1999
    ..for heart studies, and numerus neuroreceptor probes for brain studies, such as [11C]raclopride (dopamine D2 receptors), [11C]NNC 112 {dopamine D1 receptors), [11C]WAY 100635 (serotonin 5HT1A receptors), and [11C]McNeil 5652 (..
  61. MICROPET POSITRON EMISSION TOMOGRAPHY SCANNER
    Robert Mach; Fiscal Year: 1999
    ..mm in all directions, is not capable of separating these structures and our PET studies currently measure dopamine D2 receptors in the entire basal ganglia complex (caudate, putamen and nucleus accumbens)...
  62. NOVEL ASSAY FOR RECEPTOR PROFILING OF ANTIPSYCHOTICS
    Jianming Lu; Fiscal Year: 2004
    ..abstract_text> ..
  63. Dopaminergic and Endocannabinoid Interactions in Nicotine Dependence
    KELLY COSGROVE; Fiscal Year: 2009
    ..These studies will ultimately provide information on how to more successfully treat tobacco smoking. ..
  64. ADENOSINE /DOPAMINE INTERACTIONS IN A2A RECEPTOR KO MICE
    Jiang Fan Chen; Fiscal Year: 2002
    ..abstract_text> ..
  65. Ethanol regulation of signaling: from cells to behavior
    Ivan Diamond; Fiscal Year: 2009
    ..A2A receptors in the central nervous system (CNS) and is characterized by co-expression of A2A with dopamine D2 receptors (D2) on the same neurons...