cannabinoid receptors

Summary

Summary: A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.

Top Publications

  1. ncbi Molecular characterization of a peripheral receptor for cannabinoids
    S Munro
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 365:61-5. 1993
  2. ncbi Cannabidiol--recent advances
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Chem Biodivers 4:1678-92. 2007
  3. ncbi Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program
    Luc Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
    Diabetes Care 31:S229-40. 2008
  4. ncbi Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
    Christel Rousseaux
    Institut National de la Santé et de la Recherche Médicale INSERM U795, Hôpital Swynghedauw, Rue A Verhaeghe, 59037 Lille Cedex, France
    Nat Med 13:35-7. 2007
  5. ncbi Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, New Jersey 07470, USA
    Int Rev Neurobiol 88:335-69. 2009
  6. ncbi Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands
    V M Showalter
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    J Pharmacol Exp Ther 278:989-99. 1996
  7. ncbi Cannabinoid physiology and pharmacology: 30 years of progress
    Allyn C Howlett
    Neuroscience of Drug Abuse Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    Neuropharmacology 47:345-58. 2004
  8. ncbi Fatty acid amide hydrolase deficiency limits early pregnancy events
    Haibin Wang
    Department of Pediatrics, Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 116:2122-31. 2006
  9. ncbi The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors
    Mélina Dani
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, H2W 1T8, Quebec, Canada
    Eur J Pharmacol 573:214-5. 2007
  10. ncbi Tuning the oviduct to the anandamide tone
    Herbert Schuel
    Division of Anatomy and Cell Biology, Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Clin Invest 116:2087-90. 2006

Research Grants

  1. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    Michael Camilleri; Fiscal Year: 2009
  2. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2009
  3. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2010
  4. Protective Effects of Cannabinoids in HIV Neuropathogenesis
    ROBERT BRYAN ROCK; Fiscal Year: 2010
  5. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
  6. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2007
  7. Opioids,Cannabinoids,Chemokines:Neuroimmune Interactions
    Martin Adler; Fiscal Year: 2006
  8. ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACH
    Andrea Hohmann; Fiscal Year: 2007
  9. MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODEL
    CLARA SANUDO PENA; Fiscal Year: 2002
  10. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2009

Detail Information

Publications187 found, 100 shown here

  1. ncbi Molecular characterization of a peripheral receptor for cannabinoids
    S Munro
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 365:61-5. 1993
    ..Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen...
  2. ncbi Cannabidiol--recent advances
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Chem Biodivers 4:1678-92. 2007
    ..The plethora of positive pharmacological effects observed with CBD make this compound a highly attractive therapeutic entity...
  3. ncbi Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program
    Luc Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
    Diabetes Care 31:S229-40. 2008
    ....
  4. ncbi Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
    Christel Rousseaux
    Institut National de la Santé et de la Recherche Médicale INSERM U795, Hôpital Swynghedauw, Rue A Verhaeghe, 59037 Lille Cedex, France
    Nat Med 13:35-7. 2007
    ..found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of ..
  5. ncbi Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, New Jersey 07470, USA
    Int Rev Neurobiol 88:335-69. 2009
    ..Thus, understanding the ECS in the human body and brain will contribute to elucidating this natural regulatory mechanism in health and disease...
  6. ncbi Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands
    V M Showalter
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    J Pharmacol Exp Ther 278:989-99. 1996
    Two cannabinoid receptors have been identified to date; one is located predominantly in the central nervous system (CB1), whereas the other is located exclusively in the periphery (CB2)...
  7. ncbi Cannabinoid physiology and pharmacology: 30 years of progress
    Allyn C Howlett
    Neuroscience of Drug Abuse Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    Neuropharmacology 47:345-58. 2004
    ..One very important role for CB1 antagonists will be in the treatment of craving in the disease of substance abuse...
  8. ncbi Fatty acid amide hydrolase deficiency limits early pregnancy events
    Haibin Wang
    Department of Pediatrics, Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 116:2122-31. 2006
    ..This study uncovers what we believe to be a novel regulation of preimplantation processes, which could be clinically relevant for fertility regulation in women...
  9. ncbi The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors
    Mélina Dani
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, H2W 1T8, Quebec, Canada
    Eur J Pharmacol 573:214-5. 2007
    ..These effects were inhibited by the administration of cannabinoid CB(1) (AM251) and CB(2) (AM630) receptor antagonists. The participation of the peripheral cannabinoid system in paracetamol analgesia is suggested...
  10. ncbi Tuning the oviduct to the anandamide tone
    Herbert Schuel
    Division of Anatomy and Cell Biology, Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Clin Invest 116:2087-90. 2006
    ..Anandamide (N-arachidonoylethanolamide) is a lipid signal molecule that was the first endogenous agonist for cannabinoid receptors to be discovered...
  11. ncbi Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    P M Zygmunt
    Department of Clinical Pharmacology, Institute of Laboratory Medicine, University of Lund, Sweden
    Nature 400:452-7. 1999
    ..The vanilloid receptor may thus be another molecular target for endogenous anandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.
  12. ncbi The endogenous cannabinoid system controls extinction of aversive memories
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Nature 418:530-4. 2002
    ..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala...
  13. ncbi Functions of cannabinoid receptors in the hippocampus
    S N Davies
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Neuropharmacology 42:993-1007. 2002
    ..to review the effects of cannabinoids on hippocampal function and evaluate the evidence that hippocampal cannabinoid receptors play a role in learning and formation of memory...
  14. ncbi N-Acylethanolamines in human reproductive fluids
    Herbert Schuel
    Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Chem Phys Lipids 121:211-27. 2002
    ..AEA is an endogenous agonist (endocannabinoid) for cannabinoid receptors. It binds with higher affinity to type CB1 than to type CB2 cannabinoid receptors...
  15. ncbi Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells
    Catherine Lombard
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Leuk Res 29:915-22. 2005
    Targeting cannabinoid receptors has recently been shown to trigger apoptosis and offers a novel treatment modality against malignancies of the immune system...
  16. ncbi Role of dorsal hippocampal cannabinoid receptors and nitric oxide in anxiety like behaviours in rats using the elevated plus-maze test
    Ali Roohbakhsh
    Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
    Clin Exp Pharmacol Physiol 34:223-9. 2007
    ..4. These data imply that cannabinoids may have anxiogenic-like effects in the CA1 region of the hippocampus in which CB1 receptors and NO may be involved...
  17. ncbi Therapeutic action of cannabinoids in a murine model of multiple sclerosis
    Angel Arevalo-Martin
    Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 23:2511-6. 2003
    ....
  18. ncbi Cannabinoid receptors and the regulation of immune response
    E V Berdyshev
    The Hormel Institute, University of Minnesota, 801 16th Avenue N E, Austin, MN 55912, USA
    Chem Phys Lipids 108:169-90. 2000
    ..This progress was made possible by the discovery of cannabinoid receptors and the endogenous ligands for these receptors...
  19. ncbi Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids
    M C Beinfeld
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Neurosci Lett 301:69-71. 2001
    ..CCK release from cerebral cortical slices was not altered by WIN+...
  20. ncbi Molecular biology of cannabinoid receptors
    Beat Lutz
    Group Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Prostaglandins Leukot Essent Fatty Acids 66:123-42. 2002
    During the last decade, research on the molecular biology and genetics of cannabinoid receptors has led to a remarkable progress in understanding of the endogenous cannabinoid system, which functions in a plethora of physiological ..
  21. ncbi Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study
    Andre J Scheen
    Division of Diabetes, Nutrition and Metabolic Disorders, CHU Sart Tilman, University of Liege, Liege, Belgium
    Lancet 368:1660-72. 2006
    ..The aim of the RIO-Diabetes trial was to assess the efficacy and safety of rimonabant in overweight or obese patients with type 2 diabetes that was inadequately controlled by metformin or sulphonylureas...
  22. ncbi CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
    ..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
  23. ncbi Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein alpha-subunits with different potencies
    P L Prather
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Pharmacol 57:1000-10. 2000
    Previous studies had shown that the amplification factors for cannabinoid receptors, defined as the number of total G proteins activated per occupied receptor, differs between several rat brain regions...
  24. ncbi A computational study on cannabinoid receptors and potent bioactive cannabinoid ligands: homology modeling, docking, de novo drug design and molecular dynamics analysis
    Serdar Durdagi
    Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635, Athens, Greece
    Mol Divers 14:257-76. 2010
    ..The binding sites of receptors derived by rhodopsin-based models have been regenerated using the beta2-adrenergic based template receptors. The re-obtained models confirmed the ligand-binding pockets that were derived based on rhodopsin...
  25. ncbi Novel endogenous peptide agonists of cannabinoid receptors
    Ivone Gomes
    Department of Pharmacology and Systems Therapeutics, Mt Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 23:3020-9. 2009
    ..Taken together, these results suggest that the CB(1) receptor is involved in the integration of signals from both lipid- and peptide-derived signaling molecules...
  26. ncbi Cannabinoid receptors as therapeutic targets in the management of liver diseases
    Ariane Mallat
    INSERM, Service d Hepatologie, Hospital Henri Moudor, Creteil, France
    Drug News Perspect 21:363-8. 2008
    ..Over the past decades, cannabinoid receptors have emerged as critical mediators of acute and chronic liver injury, and pharmacological modulation of ..
  27. ncbi Cannabinoid receptors and their endogenous agonists
    C C Felder
    Neuroscience Discovery, ELI LILLY RESEARCH LABORATORY, Indianapolis, Indiana 46285, USA
    Annu Rev Pharmacol Toxicol 38:179-200. 1998
    ..of novel agonists and antagonists with receptor subtype selectivity, mice with genetic deletion of the cannabinoid receptors, and receptor-specific antibodies, which should help in providing a better understanding of the ..
  28. ncbi Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors
    F Petitet
    Rhone Poulenc Rorer S A, C R V A, Vitry sur Seine, France
    Life Sci 63:PL1-6. 1998
    ..Moreover at high concentration delta9-THC exhibits antagonist properties. Cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range.
  29. ncbi Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusion
    A V Krylatov
    Institute of Cardiology, Tomsk Scientific Center, Siberian Division of Russian Academy of Medical Sciences
    Bull Exp Biol Med 131:523-5. 2001
    ..These findings suggest that antiarrhythmic effect of HU-210 is mediated through activation of type II cannabinoid receptors rather than activation of K(+)-channels.
  30. ncbi Effects of acute systemic and intra-cerebral stimulation of cannabinoid receptors on sensorimotor gating, locomotion and spatial memory in rats
    Nico Wegener
    Brain Research Institute, Department of Neuropharmacology, University of Bremen, P O Box 330440, 28334 Bremen, Germany
    Psychopharmacology (Berl) 198:375-85. 2008
    ..They mediate neuronal effects of their ligands in various corticolimbic and striatal circuits by presynaptic regulation of transmitter release...
  31. ncbi Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cell
    Alexander Korzh
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Brain Res 1189:23-32. 2008
    ..phosphorylation of ERK by a similar mechanism that involved activation of delta-opioid receptors or CB1 cannabinoid receptors coupled to Gi/Go proteins, matrix metalloproteases, vascular endothelial growth factor (VEGF) receptors ..
  32. ncbi Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
    Robert J McKallip
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Blood 100:627-34. 2002
    ..Together, the current data demonstrate that CB2 cannabinoid receptors expressed on malignancies of the immune system may serve as potential targets for the induction of ..
  33. ncbi Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's disease
    Susan H Fox
    Manchester Movement Disorder Laboratory, Division of Neuroscience, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
    Mov Disord 17:1180-7. 2002
    ..e., levodopa-induced dyskinesia. Cannabinoid receptors are concentrated in the basal ganglia, and stimulation of cannabinoid receptors can increase gamma-..
  34. ncbi Endocannabinoid signaling in the brain
    Rachel I Wilson
    Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 296:678-82. 2002
    ..Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism...
  35. ncbi Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
    Magali Gary Bobo
    Sanofi Aventis Recherche and Développement, Discovery Research CNS Department, Montpellier, France
    Hepatology 46:122-9. 2007
    ....
  36. ncbi Cannabinoid receptors and pain
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Prog Neurobiol 63:569-611. 2001
    ..The existence of endogenous ligands for cannabinoid receptors has also been demonstrated...
  37. ncbi CB2 cannabinoid receptor-mediated peripheral antinociception
    T P Malan
    Department of Anesthesiology and Pharmacology, University of Arizona, Tucson, AZ 85724, USA
    Pain 93:239-45. 2001
    ..Peripheral antinociception without CNS effects is consistent with the peripheral distribution of CB(2) receptors. CB(2) receptor agonists may have promise clinically for the treatment of pain without CNS cannabinoid side effects...
  38. ncbi Signal transduction activated by cannabinoid receptors
    Inés Díaz-Laviada
    Departamento de Bioquímica y Biología Molecula, Facultad de Medicina, Universidad de Alcala, Madrid, Spain
    Mini Rev Med Chem 5:619-30. 2005
    ..Two types of cannabinoid receptors have been identified to date: CB(1) and CB(2) both belonging to the heptahelichoidal receptor family but ..
  39. ncbi Cannabinoid addiction: behavioral models and neural correlates
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:3326-31. 2002
    ..Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., 2000; Schlicker and Kathmann, 2001)...
  40. ncbi Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor
    Laszlo Offertaler
    Laboratory of Physiologic Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland, USA
    Mol Pharmacol 63:699-705. 2003
    ....
  41. ncbi The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalis
    Maurice R Elphick
    School of Biological Sciences, Queen Mary, University of London, E1 4NS, London, UK
    Gene 302:95-101. 2003
    The G-protein coupled cannabinoid receptors CB(1) and CB(2) are activated by Delta(9)-tetrahydrocannabinol, the psychoactive ingredient of cannabis, and mediate physiological effects of endogenous cannabinoids ('endocannabinoids')...
  42. ncbi Effect of cannabinoids on neural transmission in rat gastric fundus
    M Storr
    Department of Internal Medicine II, Technical University of Munich, Germany
    Can J Physiol Pharmacol 80:67-76. 2002
    ..The involved cannabinoid receptors are most likely located on neuronal structures...
  43. ncbi The gastrointestinal pharmacology of cannabinoids
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Curr Opin Pharmacol 1:597-603. 2001
    ..Activation of CB1 receptors inhibits gastrointestinal motility, intestinal secretion and gastric acid secretion. The enteric location of CB1 receptors could provide new strategies for the management of gut disorders...
  44. ncbi Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract
    Maria Antonietta Casu
    Neuroscienze Scarl, Via Palabanda, 9 09124-I, Cagliari, Italy
    Eur J Pharmacol 459:97-105. 2003
    ..Moreover, the dose of 0.3 microg/kg of HU 210, devoid per se of any activity on mouse intestinal propulsion, blocked the increased gastroenteric transit induced by the cannabinoid CB(1) antagonist SR 141716A...
  45. ncbi Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid
    Krista Laine
    Departments of Pharmaceutical Chemistry, University of Kuopio, Finland
    Invest Ophthalmol Vis Sci 43:3216-22. 2002
    ..In the present study, both the degradation of endogenous cannabinoids in ocular tissues and the effect on IOP of 2-AG and noladin ether were compared...
  46. ncbi The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cells
    Vardit Rubovitch
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
    Brain Res Mol Brain Res 101:93-102. 2002
    ..Hence, we suggest a cannabinoid-specific, PTX-insensitive, stimulatory effect on L-type voltage-dependent calcium channels, which is mediated by PKA and modulated by PKC and calmodulin...
  47. ncbi Evidence for novel cannabinoid receptors
    Malcolm Begg
    National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC-9413 Bethesda, MD 8092-9413, United States
    Pharmacol Ther 106:133-45. 2005
    ..To date, two G protein-coupled cannabinoid receptors have been identified by molecular cloning, CB1 receptors mainly expressed in the brain and mediating most ..
  48. ncbi Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry
    K Tsou
    Department of Psychology, Brown University, Providence, RI 02912, USA
    Neurosci Lett 254:137-40. 1998
    ..These data demonstrate that FAAH is heterogeneously distributed and this distribution exhibits considerable, although not complete, overlap with the distribution of cannabinoid CB1 receptors in rat brain...
  49. ncbi GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
    Jane E Lauckner
    Departments of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2699-704. 2008
    ..GPR55 activation also inhibits M current. These results establish GPR55 as a cannabinoid receptor with signaling distinct from CB(1) and CB(2)...
  50. ncbi Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial
    F Xavier Pi-Sunyer
    Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    JAMA 295:761-75. 2006
    ..Rimonabant, a selective cannabinoid-1 receptor blocker, may reduce body weight and improve cardiometabolic risk factors in patients who are overweight or obese...
  51. ncbi Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain
    Somsak Mitrirattanakul
    Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA 90095, USA
    Pain 126:102-14. 2006
    ....
  52. ncbi Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria
    Wentao Jia
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Mol Cancer Res 4:549-62. 2006
    ..Together, these data suggested that Raf-1/MEK/ERK/RSK-mediated Bad translocation played a critical role in THC-induced apoptosis in Jurkat cells...
  53. ncbi Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning
    P Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 9413, USA
    Br J Pharmacol 153:252-62. 2008
    ....
  54. ncbi The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Eur J Pharmacol 384:37-42. 1999
    ....
  55. ncbi [Characteristics of abnormal behavior induced by delta 9-tetrahydrocannabinol in rats]
    M Fujiwara
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jounan Ku, Fukuoka 814 0180, Japan
    Nihon Yakurigaku Zasshi 117:35-41. 2001
    ..Thus the abnormal behavior induced by THC can be a useful model for investigating mental function in humans and new drugs for the treatment of mental disorders...
  56. ncbi Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death
    Andriani Athanasiou
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem Biophys Res Commun 364:131-7. 2007
    ..These data demonstrate that AEA, THC, and HU 210 are all able to cause changes in integrated mitochondrial function, directly, in the absence of cannabinoid receptors.
  57. ncbi Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens
    D Robbe
    , 34094 Montpellier Cedex 05, France
    J Neurosci 21:109-16. 2001
    ..to the nucleus accumbens (NAc) in the actions of most drugs of abuse, the presence and functions of cannabinoid receptors (CB1) on the glutamatergic cortical afferents to the NAc have never been explored...
  58. ncbi Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta
    S P Kenney
    Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, USA
    Am J Obstet Gynecol 181:491-7. 1999
    We sought to investigate the expression of cannabinoid receptors in human placenta and BeWo choriocarcinoma cells and study their role in the regulation of the serotonin transporter.
  59. ncbi N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties
    Garry Milman
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, and Laboratory of Environmental Physiology, Faculty of Dental Medicine, Hebrew University, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 103:2428-33. 2006
    ..Many of these effects parallel those reported for abnormal cannabidiol (Abn-CBD), a synthetic agonist of a putative novel cannabinoid-type receptor. Hence, ARA-S may represent an endogenous agonist for this receptor...
  60. ncbi Cannabinoid receptors on goldfish retinal bipolar cells: electron-microscope immunocytochemistry and whole-cell recordings
    S Yazulla
    Department of Neurobiology and Behavior, University at Stony Brook, NY 11794 5230, USA
    Vis Neurosci 17:391-401. 2000
    ..Inhibition of I(K(V)) in the Mb bipolar cells by cannabinoids should result in a more tonic ON response to increments of light. As such, cannabinoids may play a role in modulating the temporal aspects of signaling in the retina...
  61. ncbi Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors
    Sandra Holt
    Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden
    Br J Pharmacol 146:467-76. 2005
    ..In conclusion, the results show that in mice, treatment with indomethacin and URB597 produce SR144528-sensitive anti-inflammatory effects in the carrageenan model of acute inflammation...
  62. ncbi Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system
    A R Schatz
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, USA
    Toxicol Appl Pharmacol 142:278-87. 1997
    ..Collectively, these results provide further evidence that CB2 is the predominant cannabinoid receptor within the immune system and that this form of the receptor is expressed on T cells...
  63. ncbi Cannabinoid receptors undergo axonal flow in sensory nerves
    A G Hohmann
    Section on Functional Neuroanatomy, National Institute of Mental Health, Bethesda, MD 20892 4070, USA
    Neuroscience 92:1171-5. 1999
    ..The present study was conducted to evaluate axonal flow of cannabinoid receptors from the dorsal root ganglion to the periphery and to identify the putative involvement of CB1 and/or CB2 ..
  64. ncbi The orphan receptor GPR55 is a novel cannabinoid receptor
    E Ryberg
    Department of Lead Generation, AstraZeneca R and D, Molndal, Sweden
    Br J Pharmacol 152:1092-101. 2007
    ..Work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in a number of physiological processes...
  65. ncbi Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids
    Kenneth Ihenetu
    Department of Biosciences, CP Snow Building, University of Hertfordshire, Hatfield Campus, College Lane, Hertfordshire AL10 9AB, Hatfield, UK
    Eur J Pharmacol 458:207-15. 2003
    ..We conclude that in HT-29 cells, TNF-alpha-induced interleukin-8 release is inhibited by cannabinoids through activation of cannabinoid CB(2) receptors...
  66. ncbi Modulation of anxiety through blockade of anandamide hydrolysis
    Satish Kathuria
    Department of Pharmacology, University of California, Irvine, California, USA
    Nat Med 9:76-81. 2003
    ..of cannabis, Delta(9)-tetrahydrocannabinol, produces in humans subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous cannabinoids may contribute to the control of emotion...
  67. ncbi R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptors
    Paola Nieri
    Department of Psychiatry, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy
    Eur J Pharmacol 459:75-81. 2003
    ....
  68. ncbi Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus
    Jimok Kim
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 22:10182-91. 2002
    ..This study reveals a new role of the muscarinic cholinergic system in mammalian brain...
  69. ncbi Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716
    Suzanne Higgs
    School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Psychopharmacology (Berl) 165:370-7. 2003
    ..The motivational changes underlying these actions remain to be determined, but may involve alterations to food palatability...
  70. ncbi Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice
    Lei Wang
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:1393-8. 2003
    ....
  71. ncbi Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor
    Ester Fride
    Department of Behavioral Sciences, College of Judea and Samaria, Ariel 44837, Israel
    Eur J Pharmacol 461:27-34. 2003
    ..We have reported previously that cannabinoid receptors play a critical role during the early suckling period: The selective cannabinoid CB(1) receptor antagonist ..
  72. ncbi Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum
    Anatol C Kreitzer
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Neuron 34:787-96. 2002
    ..Because interneurons can project over several hundred micrometers, this inhibition of firing allows cells to regulate synaptic inputs at distances well beyond the limits of endocannabinoid diffusion...
  73. ncbi Neuroscience. Stout guards of the central nervous system
    R Mechoulam
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
    Science 302:65-7. 2003
    ..showing that activation of the cannabinoid receptor CB1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy...
  74. ncbi Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwanju, Korea
    Anesthesiology 99:701-7. 2003
    ....
  75. ncbi Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons
    Robert E Hampson
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Hippocampus 13:543-56. 2003
    ....
  76. ncbi Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus
    Alexander F Hoffman
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 18:524-34. 2003
    ..Whereas activation of cannabinoid receptors via the application of the cannabinoid agonist WIN55,212-2 significantly and dose-dependently reduced ..
  77. ncbi Modulation of electrically evoked acetylcholine release through cannabinoid CB1 receptors: evidence for an endocannabinoid tone in the human neocortex
    M Steffens
    , Neurozentrum, Breisacherstrasse 64, D-79106 Freiburg, Germany
    Neuroscience 120:455-65. 2003
    ..The results show that activation of CB1 cannabinoid receptors leads to inhibition of ACh release in the human and mouse neocortex...
  78. ncbi Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate
    Isabel Lastres-Becker
    URA CEA CNRS 2210, , DRM, DSV, CEA, , 91401-Orsay Cedex, France
    Neuroreport 14:813-6. 2003
    ....
  79. ncbi Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure
    Alexander F Hoffman
    Cellular Neurobiology Branch, Section on Cellular Neurophysiology, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:4815-20. 2003
    ..These data demonstrate that long-term exposure to the active ingredient of marijuana blocks synaptic plasticity in the NAc and reduces the sensitivity of GABAergic and glutamatergic synapses to both cannabinoids and opioids...
  80. ncbi Neuroprotection by the cannabinoid agonist WIN-55212 in an in vivo newborn rat model of acute severe asphyxia
    Jose Martinez-Orgado
    Area de Pediatría y Neonatología, Fundacion Hospital Alcorcon, Avda Budapest 1, 28990 Alcorcón, Madrid, Spain
    Brain Res Mol Brain Res 114:132-9. 2003
    ..This effect is achieved through two parallel CB1-dependent and -independent mechanisms...
  81. ncbi Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro
    Jatinder Ahluwalia
    Department of Academic Anaesthetics, Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK
    Eur J Neurosci 17:2611-8. 2003
    ..These findings also suggest that anandamide could be one of the molecules responsible for the development of inflammatory heat hyperalgesia...
  82. ncbi Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes
    Amruthesh C Shivachar
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
    Biochem Pharmacol 73:2004-11. 2007
    ..These results suggest that cannabinoids and endocannabinoids may constitute a novel class of inhibitors of astroglial glutamate transport system...
  83. ncbi Effects of cannabinoid receptor agonists on immunologically induced histamine release from rat peritoneal mast cells
    Alaster H Y Lau
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Basic Medical Sciences Building, Shatin, New Territories, China
    Eur J Pharmacol 464:229-35. 2003
    ..However, more recent studies produced contradicting results. In order to evaluate if cannabinoid receptors are present in mast cells, we studied the effects of endocannabinoids (anandamide and ..
  84. ncbi Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart
    Jean Francois Bouchard
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    Life Sci 72:1859-70. 2003
    ..In conclusion, the data suggest that endogenous cannabinoids contribute to the endothelial protective effect of ischemic preconditioning in rat coronary arteries...
  85. ncbi Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity
    Reeti Katoch-Rouse
    Neuroimaging Research Branch and Cellular Neurophysiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 46:642-5. 2003
    Exploration of the central CB1 cannabinoid receptors using positron emission tomography (PET) will allow for an understanding of the pharmacological and physiological role played by these receptors in the CNS...
  86. ncbi A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
    Raquel Gomez
    University Institute of Drug Dependencies, Department of Psychobiology, University Complutense of Madrid, Madrid 28223, Spain
    J Neurosci 22:9612-7. 2002
    ..Pretreatment with SR141716A enhanced the inhibition of feeding induced by intraperitoneal administration of oleoylethanolamide. The results reveal an unexpected role for peripheral CB1 receptors in the regulation of feeding...
  87. ncbi Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture
    D Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455-0217, USA
    J Neurosci 21:RC146. 2001
    ..Thus, activation of cannabinoid receptors can modulate synaptic plasticity independent of direct effects on neurotransmitter release...
  88. ncbi Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret
    M D Van Sickle
    Neuroscience and Gastrointestinal Research Groups, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 121:767-74. 2001
    ..CONCLUSIONS: CB1r mediates the anti-emetic action of cannabinoids in the dorsal vagal complex. Endocannabinoids are a novel neuroregulatory system involved in the control of emesis...
  89. ncbi Exogenous anandamide protects rat brain against acute neuronal injury in vivo
    M van der Stelt
    Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Neurosci 21:8765-71. 2001
    ..Although our data seem to question a possible role of the endogenous cannabinoid system in establishing a brain defense system in our model, AEA may be used as a structural template to develop neuroprotective agents...
  90. ncbi Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
    Z Jarai
    Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 96:14136-41. 1999
    ..Two cannabinoid receptors, CB1 and CB2, have been cloned, and studies with the selective CB1 receptor antagonist SR141716A have ..
  91. ncbi Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus
    N Varma
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 21:RC188. 2001
    ..DSI is produced when an endocannabinoid released from pyramidal cells suppresses IPSCs by activating CB1R cannabinoid receptors located on inhibitory interneurons...
  92. ncbi The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids
    Nissar A Darmani
    Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, Missouri 63501, USA
    J Pharmacol Exp Ther 300:34-42. 2002
    ....
  93. ncbi Short-term retrograde inhibition of GABAergic synaptic currents in rat Purkinje cells is mediated by endogenous cannabinoids
    Marco A Diana
    , , 75006 Paris, France
    J Neurosci 22:200-8. 2002
    ..Here we show that, in cerebellar parasagittal slices, type 1 cannabinoid receptors (CB1Rs) are expressed at high levels in axons of GABAergic interneurons and in presynaptic terminals onto ..
  94. ncbi Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects
    M J Wallace
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0599, USA
    Eur J Pharmacol 428:51-7. 2001
    ..This study establishes a role for the cannabinoid CB1 receptor in modulating seizure activity in a whole animal model...
  95. ncbi CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord
    I J Lever
    Neuroscience Research Centre, Guy's King's and St. Thomas' School of Biomedical Sciences, King's College London, London, SE1 1UL
    Br J Pharmacol 135:21-4. 2002
    ..We have investigated a possible modulatory role for Type 1 Cannabinoid receptors (CB(1)) on the release of excitatory transmitter Substance P from the adult mouse spinal cord after ..
  96. ncbi Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat
    Silvia Conti
    Department of Biotechnology and Bioscience, Faculty of Sciences, University of Milan-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Br J Pharmacol 135:181-7. 2002
    ..6. Our findings show the antiinflammatory effect of nabilone and confirm that of palmitoylethanolamide indicating that these actions are mediated by an uncharacterized CB(2)-like cannabinoid receptor...
  97. ncbi R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism
    R Ramer
    Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, Erlangen, D-91054, Germany
    Biochem Biophys Res Commun 286:1144-52. 2001
    ..In conclusion, induction of COX-2 expression may represent a novel mechanism by which cannabinoids mediate PG-dependent effects within the central nervous system...
  98. ncbi CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum
    G Gerdeman
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212-0615, USA
    J Neurophysiol 85:468-71. 2001
    CB1 cannabinoid receptors in the neostriatum mediate profound motor deficits induced when cannabinoid drugs are administered to rodents...
  99. ncbi Leptin-regulated endocannabinoids are involved in maintaining food intake
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072, Arco Felice, Naples, Italy
    Nature 410:822-5. 2001
    ..However, alternative orexigenic pathways maintain food intake in mice deficient in neuropeptide Y. CB1 cannabinoid receptors and the endocannabinoids anandamide and 2-arachidonoyl glycerol are present in the hypothalamus, and ..
  100. ncbi The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain
    D Bridges
    Pain Research, Imperial College School of Medicine, Chelsea and Westminster Hospital Campus, London, SW10 9NH
    Br J Pharmacol 133:586-94. 2001
    ..These data indicate that cannabinoids may have therapeutic potential in neuropathic pain, and that this effect is mediated through the CB(1) receptor...
  101. ncbi Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors
    J A Wagner
    Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond, VA 23298, USA
    Eur J Pharmacol 423:203-10. 2001
    ..Differences between the hemodynamic profile of various cannabinoids may reflect quantitative differences in cannabinoid CB(1) receptor expression in different tissues and/or the involvement of as-yet-unidentified receptors...

Research Grants90

  1. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    Michael Camilleri; Fiscal Year: 2009
    ..b>Cannabinoid receptors (CBR) are on cholinergic neurons in the brain stem, stomach and colon...
  2. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2009
    ..The eCB system consists of two endogenous cannabinoid receptors, CB1 and CB2...
  3. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2010
    ..The eCB system consists of two endogenous cannabinoid receptors, CB1 and CB2...
  4. Protective Effects of Cannabinoids in HIV Neuropathogenesis
    ROBERT BRYAN ROCK; Fiscal Year: 2010
    ..little is known about the effects of cannabinoids on HIV-1 neuropathogenesis, despite the facts that cannabinoid receptors are abundantly expressed in the striatum and that the nigrostriatal dopaminergic area is highly ..
  5. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..b>Cannabinoid receptors (CBR) are on cholinergic neurons in the brain stem, stomach and colon...
  6. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2007
    ..little attention to the endocannabinoid neurotransmitter system, despite: (1) the striking abundance of cannabinoid receptors in the basal ganglia; (2) functional interactions between endocannabinoids and neurotransmitters that ..
  7. Opioids,Cannabinoids,Chemokines:Neuroimmune Interactions
    Martin Adler; Fiscal Year: 2006
    ..Mu, kappa, and delta opioid receptors and CB1 and CB2 cannabinoid receptors have been demonstrated in the immune system...
  8. ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACH
    Andrea Hohmann; Fiscal Year: 2007
    ..Newly- released 2-AG engages local cannabinoid receptors to induce nonopioid SIA, and is then subsequently deactivated through monoacylglycerol lipase (MGL)-..
  9. MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODEL
    CLARA SANUDO PENA; Fiscal Year: 2002
    ..The recent cloning and mapping of a nervous cannabinoid receptor unveiled high levels of cannabinoid receptors in the basal ganglia where they are as abundant as the receptors for dopamine...
  10. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2009
    ..little attention to the endocannabinoid neurotransmitter system, despite: (1) the striking abundance of cannabinoid receptors in the basal ganglia; (2) its ability to regulate basal ganglia function; (3) experimental evidence for ..
  11. Control of Breast Cancer by the Endocannabinoid System
    Sean McAllister; Fiscal Year: 2007
    ..tonically inhibits metastatic breast cancer cell proliferation and invasiveness through the activation of cannabinoid receptors. Our preliminary data also suggests that cannabinoid compounds possess selective efficacy, having less ..
  12. MARIJUANA EFFECTS ON IMMUNITY--NATURE AND MECHANISMS
    Herman Friedman; Fiscal Year: 2001
    ..we have developed the hypothesis that cannabinoids depress immunity to infection by acting through cannabinoid receptors (CBR) and causing an imbalance in the immune cytokine network leading to a functional depression in cell-..
  13. CANNABINOID MODULATION OF HYPERALGESIA
    Donald A Simone; Fiscal Year: 2010
    ..b>Cannabinoid receptors (CB1 and CB2) are located in the periphery, as well as the central nervous system, and modulate ..
  14. ENDOGENOUS CANNABINOIDS AND BRAIN/IMMUNE FUNCTION
    Billy Martin; Fiscal Year: 2006
    ..We are now assured that endocannabinoids produce some of their effects through known cannabinoid receptors, yet they are also capable of acting at as-yet-unidentified sites...
  15. REPRESSION OF T CELL ACTIVATION BY ENDOCANNABINOIDS
    Norbert Kaminski; Fiscal Year: 2003
    The overall goals of this 4 year research plan are two-fold: (a) to characterize the role of cannabinoid receptors CB1 and CB2 in the modulation of T-cell function by endogenous eicosinoid-like cannabinoids; and (b) to elucidate the ..
  16. MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDS
    Andrew Gifford; Fiscal Year: 2002
    ..The active ingredient of marijuana, delta 9THC, acts on specific receptors, termed cannabinoid receptors, which are abundantly expressed in many regions of the brain...
  17. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  18. ELECTROPHYSIOLOGICAL ASSESSMENT OF CANNABINOID RECEPTORS
    SAMUEL DEADWYLER; Fiscal Year: 1999
    ..application of a research program in its third year of electrophysiological assessment of the role of cannabinoid receptors in brain. In the first 2...
  19. fMRI and Cognition in Adolescent Cannabis Users
    Susan Tapert; Fiscal Year: 2007
    ..form of gray matter decreases and white matter increases, including in regions with dense distributions of cannabinoid receptors (e.g., frontal lobe, hippocampus, striatum, and cerebellum)...
  20. fMRI and Cognition in Adolescent Cannabis Users
    Susan Tapert; Fiscal Year: 2009
    ..form of gray matter decreases and white matter increases, including in regions with dense distributions of cannabinoid receptors (e.g., frontal lobe, hippocampus, striatum, and cerebellum)...