cannabinoid receptors

Summary

Summary: A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.

Top Publications

  1. ncbi Molecular characterization of a peripheral receptor for cannabinoids
    S Munro
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 365:61-5. 1993
  2. ncbi Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    Jean Pierre Despres
    Quebec Heart Institute, Laval Hospital Research Center, and the Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Ste Foy, Que, Canada
    N Engl J Med 353:2121-34. 2005
  3. ncbi Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
    Christel Rousseaux
    Institut National de la Santé et de la Recherche Médicale INSERM U795, Hôpital Swynghedauw, Rue A Verhaeghe, 59037 Lille Cedex, France
    Nat Med 13:35-7. 2007
  4. ncbi Cannabinoid receptors and their ligands
    R G Pertwee
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Prostaglandins Leukot Essent Fatty Acids 66:101-21. 2002
  5. pmc Cannabinoid receptors in acute and chronic complications of atherosclerosis
    F Mach
    Department of Internal Medicine, Division of Cardiology, Geneva University Hospital, Foundation for Medical Researches, Geneva, Switzerland
    Br J Pharmacol 153:290-8. 2008
  6. ncbi Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    Eduardo Molina-Holgado
    Department of Neural Plasticity, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 22:9742-53. 2002
  7. pmc Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors
    Sandra Holt
    Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden
    Br J Pharmacol 146:467-76. 2005
  8. ncbi Functional interaction between opioid and cannabinoid receptors in drug self-administration
    M Navarro
    Departamentos de Psicobiologia and Fisiologia, Universidad Complutense de Madrid, 28223 Madrid, Spain
    J Neurosci 21:5344-50. 2001
  9. ncbi Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors
    T Maejima
    Department of Physiology, Kanazawa University School of Medicine, Takara machi, Kanazawa 920 8640, Japan
    Neuron 31:463-75. 2001
  10. ncbi Evidence for novel cannabinoid receptors
    Malcolm Begg
    National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413 Bethesda, MD 8092 9413, United States
    Pharmacol Ther 106:133-45. 2005

Detail Information

Publications253 found, 100 shown here

  1. ncbi Molecular characterization of a peripheral receptor for cannabinoids
    S Munro
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 365:61-5. 1993
    ..Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen...
  2. ncbi Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    Jean Pierre Despres
    Quebec Heart Institute, Laval Hospital Research Center, and the Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Ste Foy, Que, Canada
    N Engl J Med 353:2121-34. 2005
    ..The Rimonabant in Obesity-Lipids (RIO-Lipids) study examined the effects of rimonabant on metabolic risk factors, including adiponectin levels, in high-risk patients who are overweight or obese and have dyslipidemia...
  3. ncbi Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
    Christel Rousseaux
    Institut National de la Santé et de la Recherche Médicale INSERM U795, Hôpital Swynghedauw, Rue A Verhaeghe, 59037 Lille Cedex, France
    Nat Med 13:35-7. 2007
    ..found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of ..
  4. ncbi Cannabinoid receptors and their ligands
    R G Pertwee
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Prostaglandins Leukot Essent Fatty Acids 66:101-21. 2002
    There are at least two types of cannabinoid receptors, CB(1) and CB(2), both coupled to G proteins. CB(1) receptors exist primarily on central and peripheral neurons, one of their functions being to modulate neurotransmitter release...
  5. pmc Cannabinoid receptors in acute and chronic complications of atherosclerosis
    F Mach
    Department of Internal Medicine, Division of Cardiology, Geneva University Hospital, Foundation for Medical Researches, Geneva, Switzerland
    Br J Pharmacol 153:290-8. 2008
    ..For these purposes, it is important to better understand the complex mechanisms of endocannabinoid signalling and potential consequences of its pharmacological modulation, as it may have both pro- and anti-atherosclerotic effects...
  6. ncbi Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    Eduardo Molina-Holgado
    Department of Neural Plasticity, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 22:9742-53. 2002
    ..Although cannabinoid receptors are distributed widely in brain, their presence has not been investigated previously in oligodendrocytes...
  7. pmc Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors
    Sandra Holt
    Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden
    Br J Pharmacol 146:467-76. 2005
    ..In conclusion, the results show that in mice, treatment with indomethacin and URB597 produce SR144528-sensitive anti-inflammatory effects in the carrageenan model of acute inflammation...
  8. ncbi Functional interaction between opioid and cannabinoid receptors in drug self-administration
    M Navarro
    Departamentos de Psicobiologia and Fisiologia, Universidad Complutense de Madrid, 28223 Madrid, Spain
    J Neurosci 21:5344-50. 2001
    ..The present results show the existence of a cross-interaction between opioid and cannabinoid systems in behavioral responses related to addiction and open new strategies for the treatment of opiate dependence...
  9. ncbi Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors
    T Maejima
    Department of Physiology, Kanazawa University School of Medicine, Takara machi, Kanazawa 920 8640, Japan
    Neuron 31:463-75. 2001
    ..involves retrograde signaling from postsynaptic metabotropic glutamate receptors (mGluRs) to presynaptic cannabinoid receptors. Activation of mGluR subtype 1 (mGluR1) expressed in cerebellar Purkinje cells (PCs) reduced ..
  10. ncbi Evidence for novel cannabinoid receptors
    Malcolm Begg
    National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413 Bethesda, MD 8092 9413, United States
    Pharmacol Ther 106:133-45. 2005
    ..To date, two G protein-coupled cannabinoid receptors have been identified by molecular cloning, CB1 receptors mainly expressed in the brain and mediating most ..
  11. ncbi Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells
    A C Kreitzer
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 29:717-27. 2001
    ..DSE may provide a way for cells to use their firing rate to dynamically regulate synaptic inputs. Together with previous studies, these findings suggest a widespread role for endogenous cannabinoids in retrograde synaptic inhibition...
  12. ncbi Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism
    Shi Di
    Division of Neurobiology, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118 5698, USA
    J Neurosci 23:4850-7. 2003
    ....
  13. ncbi Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
    Magali Gary-Bobo
    Sanofi Aventis Recherche and Développement, Discovery Research CNS Department, Montpellier, France
    Hepatology 46:122-9. 2007
    ....
  14. ncbi The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction
    S R Laviolette
    Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA
    Cell Mol Life Sci 63:1597-613. 2006
    ....
  15. ncbi Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program
    Luc Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
    Diabetes Care 31:S229-40. 2008
    ....
  16. ncbi Cannabidiol--recent advances
    Raphael Mechoulam
    Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
    Chem Biodivers 4:1678-92. 2007
    ..The plethora of positive pharmacological effects observed with CBD make this compound a highly attractive therapeutic entity...
  17. ncbi The endogenous cannabinoid system controls extinction of aversive memories
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Nature 418:530-4. 2002
    ..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala...
  18. ncbi Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus
    Jimok Kim
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 22:10182-91. 2002
    ..This study reveals a new role of the muscarinic cholinergic system in mammalian brain...
  19. ncbi CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
    ..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
  20. ncbi Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase
    Mario Van Der Stelt
    Department of Bio Organic Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands
    J Med Chem 45:3709-20. 2002
    ..aimed at finding structural requirements for the interaction of the acyl chain of endocannabinoids with cannabinoid receptors, membrane transporter protein, and fatty acid amide hydrolase (FAAH)...
  21. ncbi Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors
    Aline Quartilho
    Department of Anesthesiology, The University of Arizona, Tucson, USA
    Anesthesiology 99:955-60. 2003
    ..Agonists selective for CB2 cannabinoid receptors, which are not found in the CNS, do not produce the CNS effects typical of nonselective cannabinoid ..
  22. ncbi The enigmatic pharmacology of GPR55
    Ruth A Ross
    Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK
    Trends Pharmacol Sci 30:156-63. 2009
    ..Here, I review the recent literature in an effort to glean the key controversies and outstanding questions surrounding the interaction between cannabinoids and this orphan receptor...
  23. ncbi Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    P M Zygmunt
    Department of Clinical Pharmacology, Institute of Laboratory Medicine, University of Lund, Sweden
    Nature 400:452-7. 1999
    ..The vanilloid receptor may thus be another molecular target for endogenous anandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.
  24. ncbi Leptin-regulated endocannabinoids are involved in maintaining food intake
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072, Arco Felice, Naples, Italy
    Nature 410:822-5. 2001
    ..However, alternative orexigenic pathways maintain food intake in mice deficient in neuropeptide Y. CB1 cannabinoid receptors and the endocannabinoids anandamide and 2-arachidonoyl glycerol are present in the hypothalamus, and ..
  25. ncbi Nonpsychotropic cannabinoid receptors regulate microglial cell migration
    Lisa Walter
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 23:1398-405. 2003
    ....
  26. pmc The therapeutic potential of novel cannabinoid receptors
    Faith R Kreitzer
    Department of Pharmacology, University of Washington, Seattle, WA 98115 7280, USA
    Pharmacol Ther 122:83-96. 2009
    ..This suggests that additional cannabinoid and cannabinoid-like receptors exist. Here we will review this evidence in the context of their therapeutic value and discuss their true belonging to the endocannabinoid signaling system...
  27. ncbi LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation
    C C Felder
    Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 284:291-7. 1998
    ..LY320135 is a promising lead compound for the further development of novel, potent and selective cannabinoid antagonists of novel structure...
  28. pmc Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
    G Gobbi
    Department of Psychiatry, McGill University, Montreal, QC, Canada H1N 3V2
    Proc Natl Acad Sci U S A 102:18620-5. 2005
    ..The active constituent of cannabis, delta9-tetrahydrocannabinol, acts by binding to brain CB1 cannabinoid receptors, but an alternative approach might be to develop agents that amplify the actions of endogenous ..
  29. pmc Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach
    Maristella Adami
    Institute of Pharmacology, University of Parma, 43100 Parma, Italy
    Br J Pharmacol 135:1598-606. 2002
    ..However, the ineffectiveness of atropine in reducing the effect of HU-210 suggests that the release of non cholinergic excitatory neurotransmitters may be regulated by CB(1) receptors...
  30. ncbi Cannabinoid receptors: a brief history and "what's hot"
    Euan Scott Graham
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland
    Front Biosci (Landmark Ed) 14:944-57. 2009
    ..This review provides an overview of the current understanding of the endocannabinoid system, and then focuses on recent discoveries that we believe are likely to shape the future directions of the field...
  31. pmc Novel endogenous peptide agonists of cannabinoid receptors
    Ivone Gomes
    Department of Pharmacology and Systems Therapeutics, Mt Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 23:3020-9. 2009
    ..Taken together, these results suggest that the CB(1) receptor is involved in the integration of signals from both lipid- and peptide-derived signaling molecules...
  32. ncbi Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence
    A Castañé
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Dr Aiguader, 80, 08003 Barcelona, Spain
    Neuropharmacology 43:857-67. 2002
    ..These results demonstrate that some acute effects and motivational responses elicited by nicotine can be modulated by the endogenous cannabinoid system and support the existence of a physiological interaction between these two systems...
  33. ncbi Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation
    P Carayon
    Immunology Department, Sanofi Recherche, Montpellier, France and the Immunité et vaccination, INSERM U404, Institut Pasteur de Lyon, Lyon, France
    Blood 92:3605-15. 1998
    Two subtypes of G-protein-coupled cannabinoid receptors have been identified to date: the CB1 central receptor subtype, which is mainly expressed in the brain, and the CB2 peripheral receptor subtype, which appears particularly abundant ..
  34. ncbi Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, New Jersey 07470, USA
    Int Rev Neurobiol 88:335-69. 2009
    ..Thus, understanding the ECS in the human body and brain will contribute to elucidating this natural regulatory mechanism in health and disease...
  35. ncbi Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands
    V M Showalter
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    J Pharmacol Exp Ther 278:989-99. 1996
    Two cannabinoid receptors have been identified to date; one is located predominantly in the central nervous system (CB1), whereas the other is located exclusively in the periphery (CB2)...
  36. ncbi Endocannabinoid signaling in the brain
    Rachel I Wilson
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 296:678-82. 2002
    ..Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism...
  37. ncbi Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    L A Matsuda
    Laboratory of Cell Biology, National Institutes of Mental Health, Bethesda, Maryland 20892
    Nature 346:561-4. 1990
    ..Its messenger RNA is found in cell lines and regions of the brain that have cannabinoid receptors. These findings suggest that this protein is involved in cannabinoid-induced CNS effects (including ..
  38. pmc Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
    B F Cravatt
    The Skaggs Institute for Chemical Biology and Departments of Cell Biology and Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:9371-6. 2001
    ..FAAH may therefore represent an attractive pharmaceutical target for the treatment of pain and neuropsychiatric disorders...
  39. ncbi Control of pain initiation by endogenous cannabinoids
    A Calignano
    Dipartimento di Farmacologia Sperimentale, , Italy
    Nature 394:277-81. 1998
    The potent analgesic effects of cannabis-like drugs and the presence of CB1-type cannabinoid receptors in pain-processing areas of the brain and spinal cord indicate that endogenous cannabinoids such as anandamide may contribute to the ..
  40. ncbi N-Acylethanolamines in human reproductive fluids
    Herbert Schuel
    Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Chem Phys Lipids 121:211-27. 2002
    ..AEA is an endogenous agonist (endocannabinoid) for cannabinoid receptors. It binds with higher affinity to type CB1 than to type CB2 cannabinoid receptors...
  41. ncbi Functions of cannabinoid receptors in the hippocampus
    S N Davies
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Neuropharmacology 42:993-1007. 2002
    ..to review the effects of cannabinoids on hippocampal function and evaluate the evidence that hippocampal cannabinoid receptors play a role in learning and formation of memory...
  42. ncbi Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry
    K Tsou
    Department of Psychology, Brown University, Providence, RI 02912, USA
    Neurosci Lett 254:137-40. 1998
    ..These data demonstrate that FAAH is heterogeneously distributed and this distribution exhibits considerable, although not complete, overlap with the distribution of cannabinoid CB1 receptors in rat brain...
  43. pmc The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    Daniela Cota
    Clinical Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Invest 112:423-31. 2003
    ....
  44. ncbi International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
    A C Howlett
    Neuroscience of Drug Abuse Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina, USA
    Pharmacol Rev 54:161-202. 2002
    ..b>Cannabinoid receptors CB(1) and CB(2) exhibit 48% amino acid sequence identity...
  45. ncbi Cannabinoid receptors and pain
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Prog Neurobiol 63:569-611. 2001
    ..The existence of endogenous ligands for cannabinoid receptors has also been demonstrated...
  46. ncbi Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716
    Sandrine Hilairet
    Immunology Oncology Department, Sanofi Synthelabo Recherche, 371 Rue du Professeur J Blayac, 34184 Montpellier, Cedex 04, France
    J Biol Chem 278:23731-7. 2003
    ....
  47. ncbi Cannabinoid physiology and pharmacology: 30 years of progress
    Allyn C Howlett
    Neuroscience of Drug Abuse Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    Neuropharmacology 47:345-58. 2004
    ..One very important role for CB1 antagonists will be in the treatment of craving in the disease of substance abuse...
  48. ncbi Cannabinoid receptors and their endogenous agonists
    C C Felder
    Neuroscience Discovery, ELI LILLY RESEARCH LABORATORY, Indianapolis, Indiana 46285, USA
    Annu Rev Pharmacol Toxicol 38:179-200. 1998
    ..of novel agonists and antagonists with receptor subtype selectivity, mice with genetic deletion of the cannabinoid receptors, and receptor-specific antibodies, which should help in providing a better understanding of the ..
  49. pmc The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain
    D Bridges
    Pain Research, Imperial College School of Medicine, Chelsea and Westminster Hospital Campus, London, SW10 9NH
    Br J Pharmacol 133:586-94. 2001
    ..These data indicate that cannabinoids may have therapeutic potential in neuropathic pain, and that this effect is mediated through the CB(1) receptor...
  50. ncbi Coevolution between cannabinoid receptors and endocannabinoid ligands
    John M McPartland
    GW Pharmaceuticals, Middlebury, VT 05753, USA
    Gene 397:126-35. 2007
    ..have debated whether anandamide or 2-arachidonyl glycerol (2-AG) is a more "intrinsic" ligand of cannabinoid receptors. We addressed this debate with a coevolutionary analysis, by examining genes for CB1, CB2, and ten genes ..
  51. ncbi Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors
    F Petitet
    Rhone Poulenc Rorer S A, C R V A, Vitry sur Seine, France
    Life Sci 63:PL1-6. 1998
    ..Moreover at high concentration delta9-THC exhibits antagonist properties. Cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range.
  52. ncbi Cannabinoid receptors and their role in neuroprotection
    Mario Van Der Stelt
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, NA, Italy
    Neuromolecular Med 7:37-50. 2005
    ..If this neuroprotective function of cannabinoid receptor activation can be transferred to the clinic, it might represent an interesting target to develop neuroprotective agents...
  53. ncbi Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's disease
    Susan H Fox
    Manchester Movement Disorder Laboratory, Division of Neuroscience, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
    Mov Disord 17:1180-7. 2002
    ..e., levodopa-induced dyskinesia. Cannabinoid receptors are concentrated in the basal ganglia, and stimulation of cannabinoid receptors can increase gamma-..
  54. ncbi Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia
    M D Julian
    Instituto Cajal C S I C, Dr Arce 37, 28002 Madrid, Spain
    Neuroscience 119:309-18. 2003
    ..In conclusion, these data provide a neuroanatomical basis to explain functional interactions between endocannabinoid and dopaminergic systems in the basal ganglia...
  55. pmc Fatty acid amide hydrolase deficiency limits early pregnancy events
    Haibin Wang
    Department of Pediatrics, Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 116:2122-31. 2006
    ..This study uncovers what we believe to be a novel regulation of preimplantation processes, which could be clinically relevant for fertility regulation in women...
  56. pmc Tuning the oviduct to the anandamide tone
    Herbert Schuel
    Division of Anatomy and Cell Biology, Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Clin Invest 116:2087-90. 2006
    ..Anandamide (N-arachidonoylethanolamide) is a lipid signal molecule that was the first endogenous agonist for cannabinoid receptors to be discovered...
  57. ncbi The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors
    Mélina Dani
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, H2W 1T8, Quebec, Canada
    Eur J Pharmacol 573:214-5. 2007
    ..These effects were inhibited by the administration of cannabinoid CB(1) (AM251) and CB(2) (AM630) receptor antagonists. The participation of the peripheral cannabinoid system in paracetamol analgesia is suggested...
  58. ncbi The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2)
    Z H Song
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Mol Pharmacol 56:834-40. 1999
    ..for CB(2), molecular modeling studies were performed to probe the interacting sites between WIN55212-2 and cannabinoid receptors. In TMH5 the position 5.46 is a Phe in CB(2) versus a Val in CB(1)...
  59. ncbi Characterization of cannabinoid receptors coupled to vasorelaxation by endothelium-derived hyperpolarizing factor
    D Harris
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, UK
    Naunyn Schmiedebergs Arch Pharmacol 359:48-52. 1999
    ..cannabinoid may be an endothelium-derived hyperpolarizing factor (EDHF), and we have now characterized the cannabinoid receptors mediating these responses. EDHF-mediated vasorelaxations to carbachol (ED50=3.26+/-0...
  60. ncbi Cannabinoid receptor CB1 mRNA is highly expressed in the rat ciliary body: implications for the antiglaucoma properties of marihuana
    A Porcella
    Center for Neuropharmacology, C N R and B B Brodie Department of Neuroscience, University of Cagliari, via Porcell, 09124 I Cagliari, Italy
    Brain Res Mol Brain Res 58:240-5. 1998
    ..06+/-0.005% of beta2m). CB2 mRNA was undetectable. This expression pattern supports a specific role for the CB1 receptor in controlling intraocular pressure, helping to explain the antiglaucoma property of cannabinoids...
  61. ncbi The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain
    A Fox
    Novartis Institute for Medical Sciences, 5 Gower Place, WC1E 6BN, London, UK
    Pain 92:91-100. 2001
    ..These data show that cannabinoids are highly potent and efficacious antihyperalgesic agents in a model of neuropathic pain. This activity is likely to be mediated via an action in both the CNS and in the periphery...
  62. pmc N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties
    Garry Milman
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, and Laboratory of Environmental Physiology, Faculty of Dental Medicine, Hebrew University, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 103:2428-33. 2006
    ..Many of these effects parallel those reported for abnormal cannabidiol (Abn-CBD), a synthetic agonist of a putative novel cannabinoid-type receptor. Hence, ARA-S may represent an endogenous agonist for this receptor...
  63. ncbi The endocannabinoid system and its therapeutic exploitation
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Napoli, Italy
    Nat Rev Drug Discov 3:771-84. 2004
    ..and their endogenous ligands - now indicates a whole signalling system that comprises cannabinoid receptors, endogenous ligands and enzymes for ligand biosynthesis and inactivation...
  64. ncbi Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors
    Isao Ishii
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Ogawahigashi 4 1 1, Kodaira, Tokyo 187 8502, Japan
    Neuroreport 13:593-6. 2002
    ..These results suggest that the CB1 receptor could couple with G proteins that activate Rho (possibly G12/13) as well as Gi/o and Gs...
  65. ncbi Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example
    James Wager-Miller
    Department of Anesthesiology, University of Washington, Box 356540, Seattle, WA 98195 6540, USA
    Chem Phys Lipids 121:83-9. 2002
    ..These data provide evidence that CB1 likely exists as a dimer in vivo and that the carboxy end of the receptor may play a role in the assembly of the oligomer...
  66. ncbi Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase
    M H Rhee
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    J Med Chem 40:3228-33. 1997
    ..homolog (DMH) of cannabinol were prepared and assayed for binding to the brain and the peripheral cannabinoid receptors (CB1 and CB2), as well as for activation of CB1- and CB2-mediated inhibition of adenylylcyclase...
  67. ncbi Tea catechins' affinity for human cannabinoid receptors
    G Korte
    Department of Psychiatry, University of Regensburg, Franz Josef Strauss Allee 11, H4 R97 93053 Regensburg, Germany
    Phytomedicine 17:19-22. 2010
    ..Competitive radioligand binding assays using recombinant human cannabinoid receptors expressed in Chem-1 and CHO cells identified (-)-epigallocatechin-3-O-gallate, EGCG (K(i)=33...
  68. ncbi A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833
    Garth T Whiteside
    Purdue Pharma Discovery Research, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Eur J Pharmacol 528:65-72. 2005
    ..Furthermore, these data suggest that the mechanism of action for GW405833 does not depend on the release of endogenous opioids...
  69. ncbi Cannabinoid receptors in human astroglial tumors
    Janka Held-Feindt
    Department of Neurosurgery, Universitätsklinikum Schleswig Holstein Campus Kiel, Kiel, Germany
    J Neurochem 98:886-93. 2006
    ..These effects have been claimed to be mediated via cannabinoid receptors 1 and 2 (CB1, CB2)...
  70. ncbi Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila
    Tangying Lu
    Department of Medical Microbiology and Immunology, MDC 10 University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Eur J Pharmacol 532:170-7. 2006
    ..results suggest that THC-induced suppression of serum IL-12 is partly due to a suppression of IL-12 production by dendritic cells and that G(i) signaling and cannabinoid receptors, but not TRPV1, are involved in this suppressive effect.
  71. ncbi Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid
    Krista Laine
    Departments of Pharmaceutical Chemistry, University of Kuopio, Finland
    Invest Ophthalmol Vis Sci 43:3216-22. 2002
    ..In the present study, both the degradation of endogenous cannabinoids in ocular tissues and the effect on IOP of 2-AG and noladin ether were compared...
  72. ncbi Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus
    Alexander F Hoffman
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 18:524-34. 2003
    ..Whereas activation of cannabinoid receptors via the application of the cannabinoid agonist WIN55,212-2 significantly and dose-dependently reduced ..
  73. ncbi Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
    A G Nackley
    Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, 30602, Athens, GA, USA
    Neuroscience 119:747-57. 2003
    ....
  74. ncbi Neuronal localization of cannabinoid receptors in the basal ganglia of the rat
    M Herkenham
    Section on Functional Neuroanatomy, National Institute of Mental Health, Bethesda, MD 20892
    Brain Res 547:267-74. 1991
    b>Cannabinoid receptors have recently been characterized and localized using a high-affinity radiolabeled cannabinoid analog in section binding assays...
  75. ncbi Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating kappa-opioid and cannabinoid receptors
    J Fichna
    Division of Gastroenterology, Department of Medicine, Snyder Institute of Infection, Immunity and Inflammation III, Alberta, Canada
    Neurogastroenterol Motil 21:1326-e128. 2009
    ..Due to its specific regional action, SA or its derivatives may be useful drugs in the treatment of lower GI disorders associated with increased GI transit and diarrhoea...
  76. ncbi Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion
    L N Maslov
    Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk
    Bull Exp Biol Med 142:557-61. 2006
    ..However, endogenous cannabinoids are not involved in the development of myocardial contractile dysfunction during ischemia/reperfusion of the isolated heart...
  77. ncbi Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity
    Christian Gratzke
    Department of Clinical Chemistry and Pharmacology, Lund University Hospital, S 22185 Lund, Sweden
    Eur Urol 57:342-8. 2010
    ..However, no information is available on the distribution of CB-receptors or effects by anandamide in CC from primates or humans...
  78. ncbi The gastrointestinal pharmacology of cannabinoids: an update
    Angela A Coutts
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland
    Curr Opin Pharmacol 4:572-9. 2004
    ..Endocannabinoids also activate cannabinoid CB(2) and vanilloid VR1 receptors in certain inflammatory states. Thus endocannabinoid metabolism could provide a useful therapeutic target for many gastrointestinal disorders...
  79. ncbi The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats
    S Serra
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123, Cagliari, Italy
    Eur J Pharmacol 430:369-71. 2001
    ..The results suggest that activation of cannabinoid CB(1) receptors is essential for the acquisition of alcohol drinking behavior in animals with a genetically determined alcohol preference...
  80. ncbi Role of cannabinoid receptors in the control of gastrointestinal motility and perception
    Jean Fioramonti
    Neurogastroenterology and Nutrition Unit, INRA, 180 chemin de Tournefeuille, BP 3, F 31931 Toulouse cedex 9, France
    Expert Rev Gastroenterol Hepatol 2:385-97. 2008
    ..Experimental data indicate a visceral antinociceptive action of cannabinoid receptor agonists, which remains to be confirmed in humans...
  81. ncbi Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors
    Pier Luigi Ferrarini
    Dipartimento di Scienze Farmaceutiche, Via Bonanno 6, 56126 Pisa, Italy
    Bioorg Med Chem 12:1921-33. 2004
    b>Cannabinoid receptors have been studied extensively in view of their potential functional role in several physiological and pathological processes...
  82. ncbi Inhibition of pain responses by activation of CB(2) cannabinoid receptors
    T Philip Malan
    Department of Anesthesiology, The University of Arizona, PO Box 245114, Tucson, AZ 85724 5114, USA
    Chem Phys Lipids 121:191-200. 2002
    ..Peripheral antinociception without CNS effects is consistent with the peripheral distribution of CB(2) receptors. CB(2) receptor agonists may have promise for the treatment of pain and inflammation without CNS side effects...
  83. pmc Involvement of cannabinoid receptors in gut motility and visceral perception
    Pamela J Hornby
    Enterology Research Team, Box 776, Johnson and Johnson Pharmaceutical Research and Development LLC, Welsh and McKean Roads, Spring House, PA 19477 0776, U S A
    Br J Pharmacol 141:1335-45. 2004
    From a historical perspective to the present day, all the evidence suggests that activation of cannabinoid receptors (CBRs) is beneficial for gut discomfort and pain, which are symptoms related to dysmotility and visceral perception...
  84. ncbi (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only
    Ester Fride
    Department of Behavioral Sciences, College of Judea and Samaria, Ariel 44837, Israel
    Eur J Pharmacol 506:179-88. 2004
    ..We conclude that centrally inactive (+)-cannabidiol analogues should be further developed as antidiarrheal, antiinflammatory and analgesic drugs for gastrointestinal and other peripheral conditions...
  85. ncbi WIN55,212-2-mediated inhibition of HIV-1 expression in microglial cells: involvement of cannabinoid receptors
    R Bryan Rock
    Center for Infectious Diseases and Microbiology Translational Research and Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    J Neuroimmune Pharmacol 2:178-83. 2007
    b>Cannabinoid receptors CB(1) and CB(2) are primarily expressed in cells of the nervous and immune systems, respectively...
  86. ncbi Tricyclic pyrazoles. Part 1: synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for CB1and CB2 cannabinoid receptors
    Jean Mario Mussinu
    Dipartimento Farmaco Chimico Tossicologico, Universita di Sassari, via F Muroni 23 A, 07100 Sassari, Italy
    Bioorg Med Chem 11:251-63. 2003
    ..The various analogues were assayed for binding both to the brain and peripheral cannabinoid receptors (CB(1) and CB(2))...
  87. pmc Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown
    Patricia H Reggio
    Center for Drug Discovery, Department of Chemistry and Biochemistry, University of North Carolina Greensboro, 27402, USA
    Curr Med Chem 17:1468-86. 2010
    ..g., the serotonin and dopamine receptors), the cannabinoid receptors have neutral, highly lipophilic ligands derived from the fatty acid, arachidonic acid...
  88. pmc The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints
    Chris L Baker
    Department of Physiology and Biophysics, 3300, Hospital Drive NW, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Br J Pharmacol 142:1361-7. 2004
    ..Rather than a classic CB receptor pathway, ACEA exerts its vasomotor influence by acting via TRPV(1) receptors located on the terminal branches of capsaicin-sensitive afferent nerves innervating the joint...
  89. ncbi Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses
    J P Meschler
    Saint Louis University School of Medicine, Department of Pharmacological and Physiological Science, MO 63104, USA
    Pharmacol Biochem Behav 62:473-80. 1999
    ..Radioligand receptor binding assays employing membrane preparations from rat brains containing CB1 cannabinoid receptors, and human tonsils containing CB2 receptors, demonstrated that thujone displaced [3H]CP55940, a ..
  90. ncbi The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors
    T Bisogno
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico (VDM, TB, Arco Felice, Napoli, Italy
    Eur J Biochem 268:1982-9. 2001
    ....
  91. ncbi Cannabinoid receptors and T helper cells
    Thomas W Klein
    Department of Medical Microbiology and Immunology, University of South Florida, 12901 Bruce Downs Boulevard, Tampa, FL 33612, USA
    J Neuroimmunol 147:91-4. 2004
    ..for CB1 (SR141716A, SR1) and CB2 (SR144528, SR2) were also injected to analyze the involvement of cannabinoid receptors. It was determined that SR1 attenuated the THC suppression of IL-12Rbeta2, while SR2 attenuated the ..
  92. ncbi [Rimonabant improves cardiometabolic risk profile in obese or overweight subjects: overview of RIO studies]
    A J Scheen
    Universite de Liege, Service de Diabetologie, Nutrition et Maladies Metaboliques, CHU Sart Tilman, Liege, Belgique
    Rev Med Suisse 2:1916-23. 2006
    ..Almost half of the metabolic effects, including adiponectin increase, occur beyond weight loss, suggesting a direct peripheral effect of rimonabant...
  93. ncbi Modulation of transmitter release via presynaptic cannabinoid receptors
    E Schlicker
    Institut fur Pharmakologie und Toxikologie, Universitat Bonn, Reuterstr 2b, 53113, Bonn, Germany
    Trends Pharmacol Sci 22:565-72. 2001
    ..antagonist and inverse agonist SR141716 or CB1-receptor-deficient mice suggest that numerous presynaptic cannabinoid receptors are tonically activated by endogenous cannabinoids and/or are constitutively active...
  94. ncbi Involvement of cannabinoid receptors in the intraocular pressure-lowering effects of WIN55212-2
    Z H Song
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Pharmacol Exp Ther 292:136-9. 2000
    ..has not been established whether the intraocular pressure-lowering effects of cannabinoids are mediated by cannabinoid receptors. Aminoalkylindoles are a new class of cannabimimetics with structures entirely different from those of ..
  95. ncbi Cannabinoid addiction: behavioral models and neural correlates
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:3326-31. 2002
    ..Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., 2000; Schlicker and Kathmann, 2001)...
  96. ncbi An introduction to the endocannabinoid system: from the early to the latest concepts
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry and Institute of Cybernetics, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Best Pract Res Clin Endocrinol Metab 23:1-15. 2009
    ..The complexity of the endocannabinoid system and of its physiological and pathological function is outlined in this introductory chapter, for a better understanding of the subsequent chapters in this special issue...
  97. ncbi Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation
    W S Edgemond
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mol Pharmacol 54:180-8. 1998
    ..The addition of hydroxyl groups at other positions affects ligand affinity for CB receptors; both the position of the hydroxyl group and the configuration of the remaining double bonds are determinants of affinity...
  98. ncbi Functional assessment of neuronal cannabinoid receptors in the muscular layers of human ileum and colon
    L Manara
    Research Centre Sanofi Midy, Milan, Italy
    Dig Liver Dis 34:262-9. 2002
    ..The notion that specific receptors account for the ability of natural and synthetic cannabinoids to alter physiological functions, prompted this study aimed at assessing their functional presence in the human gut...
  99. ncbi Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors
    Marco Koch
    Dr Senckenbergische Anatomie, Anatomisches Institut II, Fachbereich Medizin der Johann Wolfgang Goethe Universität, Frankfurt Main, Germany
    J Neurochem 98:267-78. 2006
    Cannabinoids modulate neuronal and neuroendocrine circuits by binding to cannabinoid receptors acting upon cAMP/Ca(2+)-mediated intracellular signaling cascades...
  100. ncbi Cannabinoid receptors as therapeutic targets
    Spiro Pavlopoulos
    Department of Pharmaceutical Sciences, University of Connecticut, Storss, CT 06269, USA
    Curr Pharm Des 12:1751-69. 2006
    The cannabinoid receptors CB1 and CB2 are family A, G-protein Coupled Receptors that mediate the effects of cannabinoids, a class of compounds that are so named because the first members were isolates of the cannabis plant...
  101. ncbi Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells
    Catherine Lombard
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Leuk Res 29:915-22. 2005
    Targeting cannabinoid receptors has recently been shown to trigger apoptosis and offers a novel treatment modality against malignancies of the immune system...

Research Grants72

  1. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..The eCB system consists of two endogenous cannabinoid receptors, CB1 and CB2...
  2. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY ELIZABETH BUCKLEY-NIEVES; Fiscal Year: 2012
    ..host resistance to bacterial, viral and parasitic infections, presumably through the central or peripheral cannabinoid receptors, CB1R or CB2R, respectively...
  3. CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a
    DANA E contact SELLEY; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: CB1 cannabinoid receptors mediate many of the effects of marijuana and interact with naturally occurring marijuana-like substances ..
  4. Protective Effects of Cannabinoids in HIV Neuropathogenesis
    ROBERT BRYAN ROCK; Fiscal Year: 2012
    ..little is known about the effects of cannabinoids on HIV-1 neuropathogenesis, despite the facts that cannabinoid receptors are abundantly expressed in the striatum and that the nigrostriatal dopaminergic area is highly ..
  5. The Biosynthesis of Anandamide
    Dale G Deutsch; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Anandamide (AEA) is a naturally occurring ligand that binds to cannabinoid receptors and is widely distributed in the body, particularly the nervous system...
  6. Endocannabinoid Intracellular Transporters
    Dale G Deutsch; Fiscal Year: 2010
    ..anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are the major signaling molecules for the cannabinoid receptors CB1 and CB2. Unlike most other neurotransmitters, the endocannabinoids are neutral hydrophobic molecules...
  7. Prenatal Cannabis Exposure and Epigenetic Mechanisms Underlying Vulnerability to
    CLAUDIA VARGAS MORRIS; Fiscal Year: 2013
    ..Cannabis is known to target cannabinoid receptors, which are involved in hardwiring the brain during the prenatal period and are expressed on neurons that ..
  8. Central Endocannabinoid System Dysfunction and Hypertension
    Jeanne L Seagard; Fiscal Year: 2013
    ..studies, evidence was obtained that suggested that endocannabinoids (ECBs), endogenous agonists of neural cannabinoid receptors (CB1Rs), provide a presynaptic mechanism that modulates central integration of baroreceptor inputs in the ..
  9. Cannabinoid modulation of microglial response to the HIV protein Tat
    Guy A Cabral; Fiscal Year: 2013
    ..we will test the hypothesis that select exogenous cannabinoids act through the CB2R, and possibly other cannabinoid receptors, to dampen microglial inflammatory responses to Tat...
  10. A human neuron/oligodendrocyte co-culture model to study myelination
    Bridget Shafit-Zagardo; Fiscal Year: 2013
    ..OPC maturation and axon ensheathment, and test whether in combination with gas6, the activation of cannabinoid receptors, or the retinoid X receptor (RXR) can promote further the maturation and myelinating activity of human OPC ..
  11. fMRI and Cognition in Adolescent Cannabis Users
    Susan F Tapert; Fiscal Year: 2010
    ..form of gray matter decreases and white matter increases, including in regions with dense distributions of cannabinoid receptors (e.g., frontal lobe, hippocampus, striatum, and cerebellum)...
  12. BEHAVIORAL EFFECTS OF CB2 CANNABINOID RECEPTORS (CB2RS)
    Emmanuel S Onaivi; Fiscal Year: 2012
    ..There are two well characterized cannabinoid receptors (CB1Rs and CB2Rs) that are activated by cannabinoids and eCBs with multiple physiological roles, and ..
  13. Endocannabinoid signaling in a model of cancer pain
    Virginia S Seybold; Fiscal Year: 2013
    ..Monoglyceride lipase (MGL) degrades 2AG in vivo. Specific aim 2 examines the sources of MGL and cannabinoid receptors that underlie the anti- hyperalgesic effect of MGL inhibition in the periphery and whether expression of ..
  14. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2013
    ..g., anandamide, 2-arachidonyl glycerol, 2-AG) modulate neurotransmission by activating presynaptic cannabinoid receptors and inhibiting neurotransmitter release...
  15. Allosteric Modulators of CB1 Cannabinoid Receptor
    GANESHSINGH ARJUNSINGH THAKUR; Fiscal Year: 2010
    ..Molecules that modify the action of cannabinoid receptors offer a new, potentially very safe approach for drugs to treat these and other diseases.
  16. Imaging Brain Cannabinoid Receptors (CB1) in Schizophrenia
    DEEPAK CYRIL D'SOUZA; Fiscal Year: 2013
    ..fluid (CSF) endocannabinoid levels and 2) post-mortem findings of regional alterations in brain cannabinoid receptors (CB1R) in schizophrenia...
  17. CB1 and DA Receptor Deletion by RNAi in Cocaine Self-Administration
    CAROLINE EVELYN BASS; Fiscal Year: 2011
    ..hypothesis-driven research project to investigate addiction processes that are modulated by dopamine and cannabinoid receptors in the mesocorticolimbic system. Dr...
  18. Synthetic cannabinoids as novel therapeutic strategies against non-small cell lun
    Ramesh K Ganju; Fiscal Year: 2012
    ..Cannabinoids have been shown to mediate their effects through cannabinoid receptors CB1 and CB2...
  19. The regulation of cannabinoid receptors in microglial cells during HIV infection
    CATALIN FILIPEANU; Fiscal Year: 2012
    ..However, there are currently no data on the effects of HIV-infection on expression levels and signaling of cannabinoid receptors, or on the effects of cannabinoid receptor activation on the progression of HIV-infection...
  20. Endocannabinoid signaling in alcohol induced hepatic steatosis
    LEAH YU LIU; Fiscal Year: 2013
    ..We have recently generated zebrafish mutants for the two cannabinoid receptors, cnr1 and cnr2, using transcription activator-like effector nucleases (TALEN), a novel technique recently ..
  21. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2012
    ..little attention to the endocannabinoid neurotransmitter system, despite: (1) the striking abundance of cannabinoid receptors in the basal ganglia;(2) its ability to regulate basal ganglia function;(3) experimental evidence for anti-..
  22. Cannabinoid-based therapy and approaches to quantify pain in sickle cell disease
    Kalpna Gupta; Fiscal Year: 2013
    ..cellular receptors and signaling pathways, which will be intercepted by cannabinoids utilizing specific cannabinoid receptors (CBR). SA#2. Cannabinoids will attenuate central sensitization in sickle mice and pain in human subjects...
  23. Functional Analysis of Cyclooxygenase-2
    Lawrence J Marnett; Fiscal Year: 2013
    ..2-AG and AEA are the two best characterized endogenous ligands for the cannabinoid receptors - CB1 and CB2 - and exert a plethora of effects through these receptors...
  24. Cannabinoid Receptor Interacting Protein1a Structure-Function
    LAWRENCE CHRISTOPHER BLUME; Fiscal Year: 2013
    ..widely used illicit drug in the United Sates, and produces its psychotropic effects primarily through CB1 cannabinoid receptors in the central nervous system...
  25. Endocannabinoid Signaling During Early Pregnancy
    Sudhansu K Dey; Fiscal Year: 2012
    ..anandamide) and 2-arachidonoyglycerol (2-AG) function as endogenous ligands (endocannabinoids) for cannabinoid receptors (CB1 and CB2). CB1 and CB2 are G protein-coupled receptors...
  26. Endocannabinoid Inactivation:Plasma Membrane Uptake and Cellular Trafficking
    Dale G Deutsch; Fiscal Year: 2012
    ..anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are the major signaling molecules for the cannabinoid receptors CB1 and CB2...
  27. Substance Use and Immunity in HIV+ Adolescents by Systems Biology
    Maureen M Goodenow; Fiscal Year: 2013
    ..unreadable]9-tetrahydrocannabinol [TCH], the main psychoactive component in marijuana, targets endogenous cannabinoid receptors expressed by cells of brain and central nervous system [CB1], as well as by immune cells [CB2]...
  28. Structure-Function Studies of Endocannabinoid Biosynthetic Enzymes
    JOSE OLUCHA - ALVAREZ; Fiscal Year: 2013
    ..2- arachidonoylglycerol (2-AG) is a lipid messenger of the ECS, full agonist at Cannabinoid Receptors type 1 (CB1) and type 2 (CB2)...
  29. Endogenous Cannabinoids and NGF Signaling in Pain Associated with Cystitis
    DALE EDMOND BJORLING; Fiscal Year: 2013
    ..We will also use mice that are deficient in FAAH or one of the primary cannabinoid receptors (CB1 or CB2) to test the novel hypothesis that endocannabinoids inhibit visceral pain arising from bladder ..
  30. Regulation of synaptic plasticity by eCBs in adult and aged mammalian cortex
    Karen L Montey; Fiscal Year: 2012
    ..The proposed experiments manipulate cortical inhibition indirectly through use of type 1 cannabinoid receptors (CBIRs) in adult postnatal day 150 (P150) and aged (P700) rats...
  31. CANNABINOID RECEPTORS IN NEURONAL CELLS AND BRAIN
    Allyn C Howlett; Fiscal Year: 2013
    ..Development of legitimate CB1 medicines can dispel myths associated with the notion of "medical marihuana". ..
  32. Presynaptic Forms of Long-Term Plasticity in the CNS
    Pablo E Castillo; Fiscal Year: 2013
    ..are produced "on-demand" from neurons, cross the synaptic cleft, and by activating presynaptic cannabinoid receptors, suppress transmitter release in a transient or long-term manner...
  33. Cannabinergic Ligands and Drugs
    Alexandros Makriyannis; Fiscal Year: 2012
    ..These include the two cannabinoid receptors (CB1, CB2), the endocannabinoid deactivating enzymes (FAAH, MGL), and the transporter system (AT)...
  34. The neuronal basis of cannabis-induced developmental deficits in the CNS
    Yasmin L Hurd; Fiscal Year: 2012
    ..the cellular specification of endocannabinoid signaling during brain development is surprising given that cannabinoid receptors are the preferred cellular targets of 9-tetrahydrocannabinol (THC), the active component from cannabis, ..
  35. Neuroendocrine Supersensitivity of 5-HT2A Receptors
    GONZALO ANDRES CARRASCO; Fiscal Year: 2010
    ..We hypothesize that desensitization/downregulation of synaptic cannabinoid receptors mediates the cannabinoid withdrawal-induced supersensitivity of 5-HT2A receptors...
  36. Development of PET radioligands for cerebral cannabinoid receptor (CB1)
    Andrew G Horti; Fiscal Year: 2011
    ..Development of radioligands for positron emission tomography (PET) imaging of the cannabinoid receptors type 1 (CB1) is of great importance for studying the role of the cannabinoid system in neuropsychiatric ..
  37. Cannabinoids and Neuroimmune Interactions
    Edgar Alfonso Romero Sandoval; Fiscal Year: 2010
    ..Cannabinoid agonists acting on cannabinoid receptors (CBR) 1 and 2 have shown great promise in both animal and human studies as analgesics, without a clear ..
  38. Control of Breast Cancer by the Endocannabinoid System
    Sean McAllister; Fiscal Year: 2009
    ..tonically inhibits metastatic breast cancer cell proliferation and invasiveness through the activation of cannabinoid receptors. Our preliminary data also suggests that cannabinoid compounds possess selective efficacy, having less ..
  39. STATUS EPILEPTICUS REORGANIZES CANNABINOID RECEPTORS
    ROBERT JOHN DELORENZO; Fiscal Year: 2010
    ..These studies may lead to the development of novel therapeutic interventions to reverse the effects of SE on AE and memory loss by pharmacologically regulating the endogenous CB1system. ..
  40. Examination of endocannabinoid elevation and extinction learning
    JASON MICHAEL WIEBELHAUS; Fiscal Year: 2013
    ..9-THC is one of a group of exogenous cannabinoids that binds to and activates CB1 cannabinoid receptors that are widely distributed throughout the CNS...
  41. MAGL Inhibition in Prevention and Treatment of Alzheimer's Disease
    Chu Chen; Fiscal Year: 2012
    ..and plasticity by activation of the cannabinoid receptor (CB1R), a predominantly expressed type of cannabinoid receptors in the brain...
  42. Characterization of anandamide transport in brain
    Daniele Piomelli; Fiscal Year: 2013
    ..chronic pain-related responses in rodents by enhancing the intrinsic activity of anandamide at CB1-type cannabinoid receptors located outside the CNS...
  43. Activity Dependence of Endocannabinoid Signaling
    MICHAEL MYOGA; Fiscal Year: 2010
    ..They are released by postsynaptic cells and activate presynaptic G protein-coupled type- 1 cannabinoid receptors (CBIRs). CB1R signaling can induce both short-term and long-term depression (STD and LTD)...
  44. Adolescent Cannabis Use, Complex Brain Network Connectivity &Schizophrenia Risk
    Beng Choon Ho; Fiscal Year: 2013
    ..Activation of cannabinoid receptors is vital in regulating neural cell survival, brain development and neuroplasticity...
  45. Effects of Chronic THC in Adolescence
    Peter J Winsauer; Fiscal Year: 2010
    ..In addition, subjects in each behavioral group will be sacrificed to examine potential changes in cannabinoid receptors and endogenous cannabinoid levels in relevant brain areas...
  46. Post-translational Regulation of Opioid and Cannabinoid Receptors
    Lakshmi A Devi; Fiscal Year: 2013
    ..that opioid receptors dimerize with each other as well as with other G protein-coupled receptors such as cannabinoid receptors. In order to explore the molecular consequences of heterodimerization in vivo and its relevance to ..
  47. Endocannabinoid Metabolic Enzymes: Structure, Function, In Vivo Inhibition
    Benjamin F Cravatt; Fiscal Year: 2013
    ..AEA) and 2-arachidonoylglycerol (2-AG) are lipid transmitters that activate the central and peripheral cannabinoid receptors (CB1 and CB2, respectively) to regulate a broad range of physiological processes, including pain sensation,..
  48. Aggregation Properties of Hemopressin
    Surendra Kumar Nayak; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The endocannabinoid system consists of two cannabinoid receptors CB1 and CB2, which are G-protein coupled receptors and activated by mainly lipidic compounds...
  49. Regulation of Basal Endocannabinoid Tone in the Hippocampus
    Jimok Kim; Fiscal Year: 2013
    ..Once released into extracellular space, endocannabinoids bind to presynaptic cannabinoid receptors and suppress synaptic transmission...
  50. Neuropeptides, Processing Enzymes, and Drug Abuse
    Lloyd D Fricker; Fiscal Year: 2013
    ..peptides (N-terminally extended forms of a peptide named "hemopressin") were found to be agonists of CB1 cannabinoid receptors. These hemopressin peptides are present in mouse brain at levels comparable to many of the abundant ..
  51. Cannabinoid Receptor One-B Arrestin Interactions
    Rebecca Stadel; Fiscal Year: 2012
    ..will improve our understandings of the mechanisms involved in desensitization and internalization of cannabinoid receptors, and by elucidating the exact nature of the CB1-P-arrestin complex, may elucidate novel drug targets...
  52. Neurocognitive Disinhibition and Cannabis Addiction: A Career Development Award
    Raul Gonzalez; Fiscal Year: 2010
    ..b>Cannabinoid receptors are densely distributed in the human brain and results from neuroimaging studies of abstinent cannabis ..
  53. A novel cannabinoid receptor in cortical nerve terminals
    Stephen M Smith; Fiscal Year: 2011
    ..Identification of all the cannabinoid receptors is central to this problem...
  54. Modulation of atherosclerosis by cannabinoid type 2 receptor
    Douglas P Thewke; Fiscal Year: 2013
    ..to the active ingredient in marijuana and exert their effects by binding to cell surface receptors called cannabinoid receptors. Recent studies have shown cannabinoid receptors are dysregulated in a number of different inflammatory ..
  55. Cannabinoid Modulation of Capsaicin-Sensitive Nociceptors
    Kenneth M Hargreaves; Fiscal Year: 2010
    ..we have developed a hypothesis for peripheral cannabinoid antihyperalgesia/antiallodynia via ionotropic cannabinoid receptors. We propose to test the central hypothesis that peripheral cannabinoid antihyperalgesia/ antiallodynia is ..
  56. CANNABINOID MODULATION OF HYPERALGESIA
    DONALD SIMONE; Fiscal Year: 2013
    ..b>Cannabinoid receptors (CB1 and CB2) are located in the periphery, as well as the central nervous system, and modulate ..
  57. Neuronal cannabinoids
    KENNETH P MACKIE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): CB1 cannabinoid receptors mediate the psychoactivity of cannabis, the most commonly abused illicit drug, and are also attractive therapeutic targets...
  58. Investigation of THC Receptors
    Jenny L Wiley; Fiscal Year: 2012
    ..New cannabinoid orthosteric agonists and allosteric modulators for CB1, CB2 and new cannabinoid receptors, as well as neutral antagonists, hold promise as therapeutic agents for treatment of drug dependence, ..
  59. Treatment of Cannabinoid Withdrawal in Rhesus Monkeys
    Lance R McMahon; Fiscal Year: 2013
    ..useful actions and abuse liability of cannabinoids vary as a function of pharmacologic efficacy at cannabinoid receptors. Moreover, it is not clear whether pharmacologic modulation (e.g...
  60. Inhibition of Endocannabinoid Biosynthesis via Diacylglycerol Lipase
    RICHARD DUCLOS; Fiscal Year: 2009
    ..amide hydrolase (FAAH), the putative endocannabinoid transporter system, as well as for affinity to the cannabinoid receptors CB1 and CB2...
  61. Default Mode and Control Brain Networks in Cannabis Dependence, and Abstinence
    PATRICK DAVID SKOSNIK; Fiscal Year: 2013
    ..Cannabis and associated phytocannabinoids exert their effects through the activation of central cannabinoid receptors (CB1R)...
  62. Cannabimimetic Ligands and Endocannabinoid Active Sites
    MAKRIYANNIS ALEXANDROS; Fiscal Year: 2011
    ..ligands will be utilized to obtain detailed structural information on the active sites of the CB1 and CB2 cannabinoid receptors (CBRs)...
  63. MOLECULAR BASIS OF CANNABINOID ACTIVITY
    Alexandros Makriyannis; Fiscal Year: 2013
    ..pharmacophoric profiles of key compound classes that directly modulate the functions of the CB1 and CB2 cannabinoid receptors (CBRs)...
  64. The role of cannabinoid signaling in the nematode Caenorhabditis elegans
    MATTHEW SIMON GILL; Fiscal Year: 2010
    ..In addition to the two main cannabinoid receptors there is increasing evidence that there are other, as yet unidentified, CB receptors in humans...
  65. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..b>Cannabinoid receptors (CBR) are on cholinergic neurons in the brain stem, stomach and colon...
  66. ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACH
    Andrea Hohmann; Fiscal Year: 2007
    ..Newly- released 2-AG engages local cannabinoid receptors to induce nonopioid SIA, and is then subsequently deactivated through monoacylglycerol lipase (MGL)-..
  67. MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODEL
    CLARA SANUDO PENA; Fiscal Year: 2002
    ..The recent cloning and mapping of a nervous cannabinoid receptor unveiled high levels of cannabinoid receptors in the basal ganglia where they are as abundant as the receptors for dopamine...
  68. REPRESSION OF T CELL ACTIVATION BY ENDOCANNABINOIDS
    Norbert Kaminski; Fiscal Year: 2003
    The overall goals of this 4 year research plan are two-fold: (a) to characterize the role of cannabinoid receptors CB1 and CB2 in the modulation of T-cell function by endogenous eicosinoid-like cannabinoids; and (b) to elucidate the ..
  69. MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDS
    Andrew Gifford; Fiscal Year: 2002
    ..The active ingredient of marijuana, delta 9THC, acts on specific receptors, termed cannabinoid receptors, which are abundantly expressed in many regions of the brain...
  70. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
    ..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
  71. Endocannabinoid Modulation of Pruritus
    JOEL SCHLOSBURG; Fiscal Year: 2009
    ..the primary active component in marijuana), produce analgesic effects mediated through combined action of cannabinoid receptors in the periphery, spine, and brain...
  72. NOVEL ENDOGENOUS CARDIOVASCULAR REGULATORS
    Edward Ishac; Fiscal Year: 2000
    ..The general aim of the present proposal is to test the hypothesis that activation of peripheral CB1 cannabinoid receptors by endogenous ligands represents a novel vasodilator mechanism involved in regulating vascular tone in ..