Genomes and Genes
Summary: A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.
Publications229 found, 100 shown here
- Molecular characterization of a peripheral receptor for cannabinoidsS Munro
MRC Laboratory of Molecular Biology, Cambridge, UK
Nature 365:61-5. 1993..Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen...
- Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemiaJean Pierre Despres
Quebec Heart Institute, Laval Hospital Research Center, and the Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Ste Foy, Que, Canada
N Engl J Med 353:2121-34. 2005..The Rimonabant in Obesity-Lipids (RIO-Lipids) study examined the effects of rimonabant on metabolic risk factors, including adiponectin levels, in high-risk patients who are overweight or obese and have dyslipidemia...
- Cannabinoid receptors in acute and chronic complications of atherosclerosisF Mach
Department of Internal Medicine, Division of Cardiology, Geneva University Hospital, Foundation for Medical Researches, Geneva, Switzerland
Br J Pharmacol 153:290-8. 2008..For these purposes, it is important to better understand the complex mechanisms of endocannabinoid signalling and potential consequences of its pharmacological modulation, as it may have both pro- and anti-atherosclerotic effects...
- Cannabinoid receptors and their ligandsR G Pertwee
Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Prostaglandins Leukot Essent Fatty Acids 66:101-21. 2002There are at least two types of cannabinoid receptors, CB(1) and CB(2), both coupled to G proteins. CB(1) receptors exist primarily on central and peripheral neurons, one of their functions being to modulate neurotransmitter release...
- Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signalingEduardo Molina-Holgado
Department of Neural Plasticity, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
J Neurosci 22:9742-53. 2002..Although cannabinoid receptors are distributed widely in brain, their presence has not been investigated previously in oligodendrocytes...
- Leptin-regulated endocannabinoids are involved in maintaining food intakeV Di Marzo
Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072, Arco Felice, Naples, Italy
Nature 410:822-5. 2001..However, alternative orexigenic pathways maintain food intake in mice deficient in neuropeptide Y. CB1 cannabinoid receptors and the endocannabinoids anandamide and 2-arachidonoyl glycerol are present in the hypothalamus, and ..
- Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cellsA C Kreitzer
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Neuron 29:717-27. 2001..DSE may provide a way for cells to use their firing rate to dynamically regulate synaptic inputs. Together with previous studies, these findings suggest a widespread role for endogenous cannabinoids in retrograde synaptic inhibition...
- Evidence for novel cannabinoid receptorsMalcolm Begg
National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413 Bethesda, MD 8092 9413, United States
Pharmacol Ther 106:133-45. 2005..To date, two G protein-coupled cannabinoid receptors have been identified by molecular cloning, CB1 receptors mainly expressed in the brain and mediating most ..
- Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptorsChristel Rousseaux
Institut National de la Santé et de la Recherche Médicale INSERM U795, Hôpital Swynghedauw, Rue A Verhaeghe, 59037 Lille Cedex, France
Nat Med 13:35-7. 2007..found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of ..
- The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addictionS R Laviolette
Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA
Cell Mol Life Sci 63:1597-613. 2006....
- The enigmatic pharmacology of GPR55Ruth A Ross
Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK
Trends Pharmacol Sci 30:156-63. 2009..Here, I review the recent literature in an effort to glean the key controversies and outstanding questions surrounding the interaction between cannabinoids and this orphan receptor...
- Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptorsT Maejima
Department of Physiology, Kanazawa University School of Medicine, Takara machi, Kanazawa 920 8640, Japan
Neuron 31:463-75. 2001..involves retrograde signaling from postsynaptic metabotropic glutamate receptors (mGluRs) to presynaptic cannabinoid receptors. Activation of mGluR subtype 1 (mGluR1) expressed in cerebellar Purkinje cells (PCs) reduced ..
- Cannabidiol--recent advancesRaphael Mechoulam
Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
Chem Biodivers 4:1678-92. 2007..The plethora of positive pharmacological effects observed with CBD make this compound a highly attractive therapeutic entity...
- Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) programLuc Van Gaal
Department of Diabetology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
Diabetes Care 31:S229-40. 2008....
- CB1 cannabinoid receptors and on-demand defense against excitotoxicityGiovanni Marsicano
Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
Science 302:84-8. 2003..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
- Cannabinoid receptors: a brief history and "what's hot"Euan Scott Graham
Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland
Front Biosci (Landmark Ed) 14:944-57. 2009..This review provides an overview of the current understanding of the endocannabinoid system, and then focuses on recent discoveries that we believe are likely to shape the future directions of the field...
- Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysisG Gobbi
Department of Psychiatry, McGill University, Montreal, QC, Canada H1N 3V2
Proc Natl Acad Sci U S A 102:18620-5. 2005..The active constituent of cannabis, delta9-tetrahydrocannabinol, acts by binding to brain CB1 cannabinoid receptors, but an alternative approach might be to develop agents that amplify the actions of endogenous ..
- Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating kappa-opioid and cannabinoid receptorsJ Fichna
Division of Gastroenterology, Department of Medicine, Snyder Institute of Infection, Immunity and Inflammation III, Alberta, Canada
Neurogastroenterol Motil 21:1326-e128. 2009..Due to its specific regional action, SA or its derivatives may be useful drugs in the treatment of lower GI disorders associated with increased GI transit and diarrhoea...
- Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinenceA Castañé
Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Dr Aiguader, 80, 08003 Barcelona, Spain
Neuropharmacology 43:857-67. 2002..These results demonstrate that some acute effects and motivational responses elicited by nicotine can be modulated by the endogenous cannabinoid system and support the existence of a physiological interaction between these two systems...
- Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiationP Carayon
Immunology Department, Sanofi Recherche, Montpellier, France and the Immunité et vaccination, INSERM U404, Institut Pasteur de Lyon, Lyon, France
Blood 92:3605-15. 1998Two subtypes of G-protein-coupled cannabinoid receptors have been identified to date: the CB1 central receptor subtype, which is mainly expressed in the brain, and the CB2 peripheral receptor subtype, which appears particularly abundant ..
- Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomachMaristella Adami
Institute of Pharmacology, University of Parma, 43100 Parma, Italy
Br J Pharmacol 135:1598-606. 2002..However, the ineffectiveness of atropine in reducing the effect of HU-210 suggests that the release of non cholinergic excitatory neurotransmitters may be regulated by CB(1) receptors...
- Novel endogenous peptide agonists of cannabinoid receptorsIvone Gomes
Department of Pharmacology and Systems Therapeutics, Mt Sinai School of Medicine, New York, NY 10029, USA
FASEB J 23:3020-9. 2009..Taken together, these results suggest that the CB(1) receptor is involved in the integration of signals from both lipid- and peptide-derived signaling molecules...
- Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligandsV M Showalter
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
J Pharmacol Exp Ther 278:989-99. 1996Two cannabinoid receptors have been identified to date; one is located predominantly in the central nervous system (CB1), whereas the other is located exclusively in the periphery (CB2)...
- Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applicationsEmmanuel S Onaivi
Department of Biology, William Paterson University, Wayne, New Jersey 07470, USA
Int Rev Neurobiol 88:335-69. 2009..Thus, understanding the ECS in the human body and brain will contribute to elucidating this natural regulatory mechanism in health and disease...
- Cannabinoid receptors and painR G Pertwee
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
Prog Neurobiol 63:569-611. 2001..The existence of endogenous ligands for cannabinoid receptors has also been demonstrated...
- International Union of Pharmacology. XXVII. Classification of cannabinoid receptorsA C Howlett
Neuroscience of Drug Abuse Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina, USA
Pharmacol Rev 54:161-202. 2002..b>Cannabinoid receptors CB(1) and CB(2) exhibit 48% amino acid sequence identity...
- The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesisDaniela Cota
Clinical Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
J Clin Invest 112:423-31. 2003....
- Control of pain initiation by endogenous cannabinoidsA Calignano
Dipartimento di Farmacologia Sperimentale, , Italy
Nature 394:277-81. 1998The potent analgesic effects of cannabis-like drugs and the presence of CB1-type cannabinoid receptors in pain-processing areas of the brain and spinal cord indicate that endogenous cannabinoids such as anandamide may contribute to the ..
- Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistryK Tsou
Department of Psychology, Brown University, Providence, RI 02912, USA
Neurosci Lett 254:137-40. 1998..These data demonstrate that FAAH is heterogeneously distributed and this distribution exhibits considerable, although not complete, overlap with the distribution of cannabinoid CB1 receptors in rat brain...
- N-Acylethanolamines in human reproductive fluidsHerbert Schuel
Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
Chem Phys Lipids 121:211-27. 2002..AEA is an endogenous agonist (endocannabinoid) for cannabinoid receptors. It binds with higher affinity to type CB1 than to type CB2 cannabinoid receptors...
- Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716Sandrine Hilairet
Immunology Oncology Department, Sanofi Synthelabo Recherche, 371 Rue du Professeur J Blayac, 34184 Montpellier, Cedex 04, France
J Biol Chem 278:23731-7. 2003....
- Functions of cannabinoid receptors in the hippocampusS N Davies
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
Neuropharmacology 42:993-1007. 2002..to review the effects of cannabinoids on hippocampal function and evaluate the evidence that hippocampal cannabinoid receptors play a role in learning and formation of memory...
- Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulationYoonkyung Do
Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
J Immunol 173:2373-82. 2004The precise role of cannabinoid receptors (CB)1 and CB2, as well as endogenous ligands for these receptors, on immune cells remains unclear...
- Cannabinoid physiology and pharmacology: 30 years of progressAllyn C Howlett
Neuroscience of Drug Abuse Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
Neuropharmacology 47:345-58. 2004..One very important role for CB1 antagonists will be in the treatment of craving in the disease of substance abuse...
- Cannabinoid receptors and their role in neuroprotectionMario Van Der Stelt
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, NA, Italy
Neuromolecular Med 7:37-50. 2005..If this neuroprotective function of cannabinoid receptor activation can be transferred to the clinic, it might represent an interesting target to develop neuroprotective agents...
- Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa ratsMagali Gary-Bobo
Sanofi Aventis Recherche and Développement, Discovery Research CNS Department, Montpellier, France
Hepatology 46:122-9. 2007....
- Coevolution between cannabinoid receptors and endocannabinoid ligandsJohn M McPartland
GW Pharmaceuticals, Middlebury, VT 05753, USA
Gene 397:126-35. 2007..have debated whether anandamide or 2-arachidonyl glycerol (2-AG) is a more "intrinsic" ligand of cannabinoid receptors. We addressed this debate with a coevolutionary analysis, by examining genes for CB1, CB2, and ten genes ..
- N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory propertiesGarry Milman
Department of Medicinal Chemistry and Natural Products, Medical Faculty, and Laboratory of Environmental Physiology, Faculty of Dental Medicine, Hebrew University, Jerusalem 91120, Israel
Proc Natl Acad Sci U S A 103:2428-33. 2006..Many of these effects parallel those reported for abnormal cannabidiol (Abn-CBD), a synthetic agonist of a putative novel cannabinoid-type receptor. Hence, ARA-S may represent an endogenous agonist for this receptor...
- Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal gangliaM D Julian
Instituto Cajal C S I C, Dr Arce 37, 28002 Madrid, Spain
Neuroscience 119:309-18. 2003..In conclusion, these data provide a neuroanatomical basis to explain functional interactions between endocannabinoid and dopaminergic systems in the basal ganglia...
- Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptorsF Petitet
Rhone Poulenc Rorer S A, C R V A, Vitry sur Seine, France
Life Sci 63:PL1-6. 1998..Moreover at high concentration delta9-THC exhibits antagonist properties. Cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range.
- Nonpsychotropic cannabinoid receptors regulate microglial cell migrationLisa Walter
Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
J Neurosci 23:1398-405. 2003....
- Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's diseaseSusan H Fox
Manchester Movement Disorder Laboratory, Division of Neuroscience, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
Mov Disord 17:1180-7. 2002..e., levodopa-induced dyskinesia. Cannabinoid receptors are concentrated in the basal ganglia, and stimulation of cannabinoid receptors can increase gamma-..
- Fatty acid amide hydrolase deficiency limits early pregnancy eventsHaibin Wang
Department of Pediatrics, Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Clin Invest 116:2122-31. 2006..This study uncovers what we believe to be a novel regulation of preimplantation processes, which could be clinically relevant for fertility regulation in women...
- The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptorsMélina Dani
Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, H2W 1T8, Quebec, Canada
Eur J Pharmacol 573:214-5. 2007..These effects were inhibited by the administration of cannabinoid CB(1) (AM251) and CB(2) (AM630) receptor antagonists. The participation of the peripheral cannabinoid system in paracetamol analgesia is suggested...
- The endogenous cannabinoid system controls extinction of aversive memoriesGiovanni Marsicano
Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Nature 418:530-4. 2002..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala...
- Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamideP M Zygmunt
Department of Clinical Pharmacology, Institute of Laboratory Medicine, University of Lund, Sweden
Nature 400:452-7. 1999..The vanilloid receptor may thus be another molecular target for endogenous anandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.
- Tuning the oviduct to the anandamide toneHerbert Schuel
Division of Anatomy and Cell Biology, Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
J Clin Invest 116:2087-90. 2006..Anandamide (N-arachidonoylethanolamide) is a lipid signal molecule that was the first endogenous agonist for cannabinoid receptors to be discovered...
- [Rimonabant improves cardiometabolic risk profile in obese or overweight subjects: overview of RIO studies]A J Scheen
Universite de Liege, Service de Diabetologie, Nutrition et Maladies Metaboliques, CHU Sart Tilman, Liege, Belgique
Rev Med Suisse 2:1916-23. 2006..Almost half of the metabolic effects, including adiponectin increase, occur beyond weight loss, suggesting a direct peripheral effect of rimonabant...
- Inhibition of pain responses by activation of CB(2) cannabinoid receptorsT Philip Malan
Department of Anesthesiology, The University of Arizona, PO Box 245114, Tucson, AZ 85724 5114, USA
Chem Phys Lipids 121:191-200. 2002..Peripheral antinociception without CNS effects is consistent with the peripheral distribution of CB(2) receptors. CB(2) receptor agonists may have promise for the treatment of pain and inflammation without CNS side effects...
- Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivationW S Edgemond
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Mol Pharmacol 54:180-8. 1998..The addition of hydroxyl groups at other positions affects ligand affinity for CB receptors; both the position of the hydroxyl group and the configuration of the remaining double bonds are determinants of affinity...
- Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptorsPier Luigi Ferrarini
Dipartimento di Scienze Farmaceutiche, Via Bonanno 6, 56126 Pisa, Italy
Bioorg Med Chem 12:1921-33. 2004b>Cannabinoid receptors have been studied extensively in view of their potential functional role in several physiological and pathological processes...
- Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptorsMarco Koch
Dr Senckenbergische Anatomie, Anatomisches Institut II, Fachbereich Medizin der Johann Wolfgang Goethe Universität, Frankfurt Main, Germany
J Neurochem 98:267-78. 2006Cannabinoids modulate neuronal and neuroendocrine circuits by binding to cannabinoid receptors acting upon cAMP/Ca(2+)-mediated intracellular signaling cascades...
- Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responsesJ P Meschler
Saint Louis University School of Medicine, Department of Pharmacological and Physiological Science, MO 63104, USA
Pharmacol Biochem Behav 62:473-80. 1999..Radioligand receptor binding assays employing membrane preparations from rat brains containing CB1 cannabinoid receptors, and human tonsils containing CB2 receptors, demonstrated that thujone displaced [3H]CP55940, a ..
- Cannabinoid receptors as therapeutic targetsSpiro Pavlopoulos
Department of Pharmaceutical Sciences, University of Connecticut, Storss, CT 06269, USA
Curr Pharm Des 12:1751-69. 2006The cannabinoid receptors CB1 and CB2 are family A, G-protein Coupled Receptors that mediate the effects of cannabinoids, a class of compounds that are so named because the first members were isolates of the cannabis plant...
- The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat jointsChris L Baker
Department of Physiology and Biophysics, 3300, Hospital Drive NW, University of Calgary, Calgary, Alberta, Canada T2N 4N1
Br J Pharmacol 142:1361-7. 2004..Rather than a classic CB receptor pathway, ACEA exerts its vasomotor influence by acting via TRPV(1) receptors located on the terminal branches of capsaicin-sensitive afferent nerves innervating the joint...
- The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptorsT Bisogno
Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico (VDM, TB, Arco Felice, Napoli, Italy
Eur J Biochem 268:1982-9. 2001....
- Cannabinoid addiction: behavioral models and neural correlatesRafael Maldonado
Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
J Neurosci 22:3326-31. 2002..Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., 2000; Schlicker and Kathmann, 2001)...
- Role of cannabinoid receptors in the control of gastrointestinal motility and perceptionJean Fioramonti
Neurogastroenterology and Nutrition Unit, INRA, 180 chemin de Tournefeuille, BP 3, F 31931 Toulouse cedex 9, France
Expert Rev Gastroenterol Hepatol 2:385-97. 2008..Experimental data indicate a visceral antinociceptive action of cannabinoid receptor agonists, which remains to be confirmed in humans...
- Cannabinoid receptors and T helper cellsThomas W Klein
Department of Medical Microbiology and Immunology, University of South Florida, 12901 Bruce Downs Boulevard, Tampa, FL 33612, USA
J Neuroimmunol 147:91-4. 2004..for CB1 (SR141716A, SR1) and CB2 (SR144528, SR2) were also injected to analyze the involvement of cannabinoid receptors. It was determined that SR1 attenuated the THC suppression of IL-12Rbeta2, while SR2 attenuated the ..
- Functional assessment of neuronal cannabinoid receptors in the muscular layers of human ileum and colonL Manara
Research Centre Sanofi Midy, Milan, Italy
Dig Liver Dis 34:262-9. 2002..The notion that specific receptors account for the ability of natural and synthetic cannabinoids to alter physiological functions, prompted this study aimed at assessing their functional presence in the human gut...
- (+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity onlyEster Fride
Department of Behavioral Sciences, College of Judea and Samaria, Ariel 44837, Israel
Eur J Pharmacol 506:179-88. 2004..We conclude that centrally inactive (+)-cannabidiol analogues should be further developed as antidiarrheal, antiinflammatory and analgesic drugs for gastrointestinal and other peripheral conditions...
- Involvement of cannabinoid receptors in gut motility and visceral perceptionPamela J Hornby
Enterology Research Team, Box 776, Johnson and Johnson Pharmaceutical Research and Development LLC, Welsh and McKean Roads, Spring House, PA 19477 0776, U S A
Br J Pharmacol 141:1335-45. 2004From a historical perspective to the present day, all the evidence suggests that activation of cannabinoid receptors (CBRs) is beneficial for gut discomfort and pain, which are symptoms related to dysmotility and visceral perception...
- The therapeutic potential of novel cannabinoid receptorsFaith R Kreitzer
Department of Pharmacology, University of Washington, Seattle, WA 98115 7280, USA
Pharmacol Ther 122:83-96. 2009..This suggests that additional cannabinoid and cannabinoid-like receptors exist. Here we will review this evidence in the context of their therapeutic value and discuss their true belonging to the endocannabinoid signaling system...
- WIN55,212-2-mediated inhibition of HIV-1 expression in microglial cells: involvement of cannabinoid receptorsR Bryan Rock
Center for Infectious Diseases and Microbiology Translational Research and Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
J Neuroimmune Pharmacol 2:178-83. 2007b>Cannabinoid receptors CB(1) and CB(2) are primarily expressed in cells of the nervous and immune systems, respectively...
- Involvement of cannabinoid receptors in the intraocular pressure-lowering effects of WIN55212-2Z H Song
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
J Pharmacol Exp Ther 292:136-9. 2000..has not been established whether the intraocular pressure-lowering effects of cannabinoids are mediated by cannabinoid receptors. Aminoalkylindoles are a new class of cannabimimetics with structures entirely different from those of ..
- Tricyclic pyrazoles. Part 1: synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for CB1and CB2 cannabinoid receptorsJean Mario Mussinu
Dipartimento Farmaco Chimico Tossicologico, Universita di Sassari, via F Muroni 23 A, 07100 Sassari, Italy
Bioorg Med Chem 11:251-63. 2003..The various analogues were assayed for binding both to the brain and peripheral cannabinoid receptors (CB(1) and CB(2))...
- Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolaseMario Van Der Stelt
Department of Bio Organic Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands
J Med Chem 45:3709-20. 2002..aimed at finding structural requirements for the interaction of the acyl chain of endocannabinoids with cannabinoid receptors, membrane transporter protein, and fatty acid amide hydrolase (FAAH)...
- An introduction to the endocannabinoid system: from the early to the latest conceptsLuciano De Petrocellis
Endocannabinoid Research Group, Institute of Biomolecular Chemistry and Institute of Cybernetics, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
Best Pract Res Clin Endocrinol Metab 23:1-15. 2009..The complexity of the endocannabinoid system and of its physiological and pathological function is outlined in this introductory chapter, for a better understanding of the subsequent chapters in this special issue...
- Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknownPatricia H Reggio
Center for Drug Discovery, Department of Chemistry and Biochemistry, University of North Carolina Greensboro, 27402, USA
Curr Med Chem 17:1468-86. 2010..g., the serotonin and dopamine receptors), the cannabinoid receptors have neutral, highly lipophilic ligands derived from the fatty acid, arachidonic acid...
- Modulation of transmitter release via presynaptic cannabinoid receptorsE Schlicker
Institut fur Pharmakologie und Toxikologie, Universitat Bonn, Reuterstr 2b, 53113, Bonn, Germany
Trends Pharmacol Sci 22:565-72. 2001..antagonist and inverse agonist SR141716 or CB1-receptor-deficient mice suggest that numerous presynaptic cannabinoid receptors are tonically activated by endogenous cannabinoids and/or are constitutively active...
- Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic diseaseRobert J McKallip
Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
Blood 100:627-34. 2002..Together, the current data demonstrate that CB2 cannabinoid receptors expressed on malignancies of the immune system may serve as potential targets for the induction of ..
- Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cellsCatherine Lombard
Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
Leuk Res 29:915-22. 2005Targeting cannabinoid receptors has recently been shown to trigger apoptosis and offers a novel treatment modality against malignancies of the immune system...
- Molecular biology of cannabinoid receptorsBeat Lutz
Group Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
Prostaglandins Leukot Essent Fatty Acids 66:123-42. 2002During the last decade, research on the molecular biology and genetics of cannabinoid receptors has led to a remarkable progress in understanding of the endogenous cannabinoid system, which functions in a plethora of physiological ..
- Therapeutic action of cannabinoids in a murine model of multiple sclerosisAngel Arevalo-Martin
Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
J Neurosci 23:2511-6. 2003....
- Cannabinoid receptors as therapeutic targets in the management of liver diseasesAriane Mallat
INSERM, Service d Hepatologie, Hospital Henri Moudor, Creteil, France
Drug News Perspect 21:363-8. 2008..Over the past decades, cannabinoid receptors have emerged as critical mediators of acute and chronic liver injury, and pharmacological modulation of ..
- Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusionA V Krylatov
Institute of Cardiology, Tomsk Scientific Center, Siberian Division of Russian Academy of Medical Sciences
Bull Exp Biol Med 131:523-5. 2001..These findings suggest that antiarrhythmic effect of HU-210 is mediated through activation of type II cannabinoid receptors rather than activation of K(+)-channels.
- Role of dorsal hippocampal cannabinoid receptors and nitric oxide in anxiety like behaviours in rats using the elevated plus-maze testAli Roohbakhsh
Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Clin Exp Pharmacol Physiol 34:223-9. 2007..4. These data imply that cannabinoids may have anxiogenic-like effects in the CA1 region of the hippocampus in which CB1 receptors and NO may be involved...
- Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled studyAndre J Scheen
Division of Diabetes, Nutrition and Metabolic Disorders, CHU Sart Tilman, University of Liege, Liege, Belgium
Lancet 368:1660-72. 2006..The aim of the RIO-Diabetes trial was to assess the efficacy and safety of rimonabant in overweight or obese patients with type 2 diabetes that was inadequately controlled by metformin or sulphonylureas...
- Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoidsM C Beinfeld
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Neurosci Lett 301:69-71. 2001..CCK release from cerebral cortical slices was not altered by WIN+...
- Cannabinoid receptors and the regulation of immune responseE V Berdyshev
The Hormel Institute, University of Minnesota, 801 16th Avenue N E, Austin, MN 55912, USA
Chem Phys Lipids 108:169-90. 2000..This progress was made possible by the discovery of cannabinoid receptors and the endogenous ligands for these receptors...
- Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein alpha-subunits with different potenciesP L Prather
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Mol Pharmacol 57:1000-10. 2000Previous studies had shown that the amplification factors for cannabinoid receptors, defined as the number of total G proteins activated per occupied receptor, differs between several rat brain regions...
- Effects of acute systemic and intra-cerebral stimulation of cannabinoid receptors on sensorimotor gating, locomotion and spatial memory in ratsNico Wegener
Brain Research Institute, Department of Neuropharmacology, University of Bremen, P O Box 330440, 28334 Bremen, Germany
Psychopharmacology (Berl) 198:375-85. 2008..They mediate neuronal effects of their ligands in various corticolimbic and striatal circuits by presynaptic regulation of transmitter release...
- Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cellAlexander Korzh
The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Brain Res 1189:23-32. 2008..phosphorylation of ERK by a similar mechanism that involved activation of delta-opioid receptors or CB1 cannabinoid receptors coupled to Gi/Go proteins, matrix metalloproteases, vascular endothelial growth factor (VEGF) receptors ..
- A computational study on cannabinoid receptors and potent bioactive cannabinoid ligands: homology modeling, docking, de novo drug design and molecular dynamics analysisSerdar Durdagi
Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635, Athens, Greece
Mol Divers 14:257-76. 2010..The binding sites of receptors derived by rhodopsin-based models have been regenerated using the beta2-adrenergic based template receptors. The re-obtained models confirmed the ligand-binding pockets that were derived based on rhodopsin...
- Cannabinoid receptors and their endogenous agonistsC C Felder
Neuroscience Discovery, ELI LILLY RESEARCH LABORATORY, Indianapolis, Indiana 46285, USA
Annu Rev Pharmacol Toxicol 38:179-200. 1998..of novel agonists and antagonists with receptor subtype selectivity, mice with genetic deletion of the cannabinoid receptors, and receptor-specific antibodies, which should help in providing a better understanding of the ..
- Endocannabinoid signaling in the brainRachel I Wilson
Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
Science 296:678-82. 2002..Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism...
- CB2 cannabinoid receptor-mediated peripheral antinociceptionT P Malan
Department of Anesthesiology and Pharmacology, University of Arizona, Tucson, AZ 85724, USA
Pain 93:239-45. 2001..Peripheral antinociception without CNS effects is consistent with the peripheral distribution of CB(2) receptors. CB(2) receptor agonists may have promise clinically for the treatment of pain without CNS cannabinoid side effects...
- Signal transduction activated by cannabinoid receptorsInés Díaz-Laviada
Departamento de Bioquímica y Biología Molecula, Facultad de Medicina, Universidad de Alcala, Madrid, Spain
Mini Rev Med Chem 5:619-30. 2005..Two types of cannabinoid receptors have been identified to date: CB(1) and CB(2) both belonging to the heptahelichoidal receptor family but ..
- Cannabinoid receptors on goldfish retinal bipolar cells: electron-microscope immunocytochemistry and whole-cell recordingsS Yazulla
Department of Neurobiology and Behavior, University at Stony Brook, NY 11794 5230, USA
Vis Neurosci 17:391-401. 2000..Inhibition of I(K(V)) in the Mb bipolar cells by cannabinoids should result in a more tonic ON response to increments of light. As such, cannabinoids may play a role in modulating the temporal aspects of signaling in the retina...
- Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondriaWentao Jia
Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
Mol Cancer Res 4:549-62. 2006..Together, these data suggested that Raf-1/MEK/ERK/RSK-mediated Bad translocation played a critical role in THC-induced apoptosis in Jurkat cells...
- The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in ratsA A Izzo
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
Eur J Pharmacol 384:37-42. 1999....
- Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tractMaria Antonietta Casu
Neuroscienze Scarl, Via Palabanda, 9 09124 I, Cagliari, Italy
Eur J Pharmacol 459:97-105. 2003..Moreover, the dose of 0.3 microg/kg of HU 210, devoid per se of any activity on mouse intestinal propulsion, blocked the increased gastroenteric transit induced by the cannabinoid CB(1) antagonist SR 141716A...
- Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placentaS P Kenney
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, USA
Am J Obstet Gynecol 181:491-7. 1999We sought to investigate the expression of cannabinoid receptors in human placenta and BeWo choriocarcinoma cells and study their role in the regulation of the serotonin transporter.
- The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalisMaurice R Elphick
School of Biological Sciences, Queen Mary, University of London, E1 4NS, London, UK
Gene 302:95-101. 2003The G-protein coupled cannabinoid receptors CB(1) and CB(2) are activated by Delta(9)-tetrahydrocannabinol, the psychoactive ingredient of cannabis, and mediate physiological effects of endogenous cannabinoids ('endocannabinoids')...
- Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune systemA R Schatz
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, USA
Toxicol Appl Pharmacol 142:278-87. 1997..Collectively, these results provide further evidence that CB2 is the predominant cannabinoid receptor within the immune system and that this form of the receptor is expressed on T cells...
- Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptorLaszlo Offertaler
Laboratory of Physiologic Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland, USA
Mol Pharmacol 63:699-705. 2003....
- Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbensD Robbe
, 34094 Montpellier Cedex 05, France
J Neurosci 21:109-16. 2001..to the nucleus accumbens (NAc) in the actions of most drugs of abuse, the presence and functions of cannabinoid receptors (CB1) on the glutamatergic cortical afferents to the NAc have never been explored...
- Cannabinoid receptors undergo axonal flow in sensory nervesA G Hohmann
Section on Functional Neuroanatomy, National Institute of Mental Health, Bethesda, MD 20892 4070, USA
Neuroscience 92:1171-5. 1999..The present study was conducted to evaluate axonal flow of cannabinoid receptors from the dorsal root ganglion to the periphery and to identify the putative involvement of CB1 and/or CB2 ..
- Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoidKrista Laine
Departments of Pharmaceutical Chemistry, University of Kuopio, Finland
Invest Ophthalmol Vis Sci 43:3216-22. 2002..In the present study, both the degradation of endogenous cannabinoids in ocular tissues and the effect on IOP of 2-AG and noladin ether were compared...
- Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptorsSandra Holt
Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden
Br J Pharmacol 146:467-76. 2005..In conclusion, the results show that in mice, treatment with indomethacin and URB597 produce SR144528-sensitive anti-inflammatory effects in the carrageenan model of acute inflammation...
- Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trialF Xavier Pi-Sunyer
Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
JAMA 295:761-75. 2006..Rimonabant, a selective cannabinoid-1 receptor blocker, may reduce body weight and improve cardiometabolic risk factors in patients who are overweight or obese...
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMichael Camilleri; Fiscal Year: 2009..b>Cannabinoid receptors (CBR) are on cholinergic neurons in the brain stem, stomach and colon...
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2010..The eCB system consists of two endogenous cannabinoid receptors, CB1 and CB2...
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2009..The eCB system consists of two endogenous cannabinoid receptors, CB1 and CB2...
- Protective Effects of Cannabinoids in HIV NeuropathogenesisROBERT BRYAN ROCK; Fiscal Year: 2010..little is known about the effects of cannabinoids on HIV-1 neuropathogenesis, despite the facts that cannabinoid receptors are abundantly expressed in the striatum and that the nigrostriatal dopaminergic area is highly ..
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMICHAEL L CAMILLERI; Fiscal Year: 2010..b>Cannabinoid receptors (CBR) are on cholinergic neurons in the brain stem, stomach and colon...
- Role of Endocannabinoids in Levodopa-Induced DyskinesiasAndrea Giuffrida; Fiscal Year: 2007..little attention to the endocannabinoid neurotransmitter system, despite: (1) the striking abundance of cannabinoid receptors in the basal ganglia; (2) functional interactions between endocannabinoids and neurotransmitters that ..
- Opioids,Cannabinoids,Chemokines:Neuroimmune InteractionsMartin Adler; Fiscal Year: 2006..Mu, kappa, and delta opioid receptors and CB1 and CB2 cannabinoid receptors have been demonstrated in the immune system...
- ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACHAndrea Hohmann; Fiscal Year: 2007..Newly- released 2-AG engages local cannabinoid receptors to induce nonopioid SIA, and is then subsequently deactivated through monoacylglycerol lipase (MGL)-..
- MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODELCLARA SANUDO PENA; Fiscal Year: 2002..The recent cloning and mapping of a nervous cannabinoid receptor unveiled high levels of cannabinoid receptors in the basal ganglia where they are as abundant as the receptors for dopamine...
- Role of Endocannabinoids in Levodopa-Induced DyskinesiasAndrea Giuffrida; Fiscal Year: 2009..little attention to the endocannabinoid neurotransmitter system, despite: (1) the striking abundance of cannabinoid receptors in the basal ganglia; (2) its ability to regulate basal ganglia function; (3) experimental evidence for ..
- Control of Breast Cancer by the Endocannabinoid SystemSean McAllister; Fiscal Year: 2007..tonically inhibits metastatic breast cancer cell proliferation and invasiveness through the activation of cannabinoid receptors. Our preliminary data also suggests that cannabinoid compounds possess selective efficacy, having less ..
- CANNABINOID MODULATION OF HYPERALGESIADonald A Simone; Fiscal Year: 2010..b>Cannabinoid receptors (CB1 and CB2) are located in the periphery, as well as the central nervous system, and modulate ..
- MARIJUANA EFFECTS ON IMMUNITY--NATURE AND MECHANISMSHerman Friedman; Fiscal Year: 2001..we have developed the hypothesis that cannabinoids depress immunity to infection by acting through cannabinoid receptors (CBR) and causing an imbalance in the immune cytokine network leading to a functional depression in cell-..
- ENDOGENOUS CANNABINOIDS AND BRAIN/IMMUNE FUNCTIONBilly Martin; Fiscal Year: 2006..We are now assured that endocannabinoids produce some of their effects through known cannabinoid receptors, yet they are also capable of acting at as-yet-unidentified sites...
- REPRESSION OF T CELL ACTIVATION BY ENDOCANNABINOIDSNorbert Kaminski; Fiscal Year: 2003The overall goals of this 4 year research plan are two-fold: (a) to characterize the role of cannabinoid receptors CB1 and CB2 in the modulation of T-cell function by endogenous eicosinoid-like cannabinoids; and (b) to elucidate the ..
- MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDSAndrew Gifford; Fiscal Year: 2002..The active ingredient of marijuana, delta 9THC, acts on specific receptors, termed cannabinoid receptors, which are abundantly expressed in many regions of the brain...
- Cannabinoid Receptors and Cerebrovascular FunctionCecilia Hillard; Fiscal Year: 2006..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
- ELECTROPHYSIOLOGICAL ASSESSMENT OF CANNABINOID RECEPTORSSAMUEL DEADWYLER; Fiscal Year: 1999..application of a research program in its third year of electrophysiological assessment of the role of cannabinoid receptors in brain. In the first 2...
- fMRI and Cognition in Adolescent Cannabis UsersSusan F Tapert; Fiscal Year: 2010..form of gray matter decreases and white matter increases, including in regions with dense distributions of cannabinoid receptors (e.g., frontal lobe, hippocampus, striatum, and cerebellum)...
- fMRI and Cognition in Adolescent Cannabis UsersSusan Tapert; Fiscal Year: 2007..form of gray matter decreases and white matter increases, including in regions with dense distributions of cannabinoid receptors (e.g., frontal lobe, hippocampus, striatum, and cerebellum)...
- fMRI and Cognition in Adolescent Cannabis UsersSusan Tapert; Fiscal Year: 2009..form of gray matter decreases and white matter increases, including in regions with dense distributions of cannabinoid receptors (e.g., frontal lobe, hippocampus, striatum, and cerebellum)...
- Substance Use and Immunity in HIV+ Adolescents by Systems BiologyMaureen M Goodenow; Fiscal Year: 2010..delta-9-tetrahydrocannabinol [TCH], the main psychoactive component in marijuana, targets endogenous cannabinoid receptors expressed by cells of brain and central nervous system [CB1], as well as by immune cells [CB2]...
- The neuronal basis of cannabis-induced developmental deficits in the CNSYasmin L Hurd; Fiscal Year: 2010..the cellular specification of endocannabinoid signaling during brain development is surprising given that cannabinoid receptors are the preferred cellular targets of 9-tetrahydrocannabinol (THC), the active component from cannabis, ..