Genomes and Genes
Summary: A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.
Publications187 found, 100 shown here
- Molecular characterization of a peripheral receptor for cannabinoidsS Munro
MRC Laboratory of Molecular Biology, Cambridge, UK
Nature 365:61-5. 1993..Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen...
- Cannabidiol--recent advancesRaphael Mechoulam
Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem 91120, Israel
Chem Biodivers 4:1678-92. 2007..The plethora of positive pharmacological effects observed with CBD make this compound a highly attractive therapeutic entity...
- Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) programLuc Van Gaal
Department of Diabetology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
Diabetes Care 31:S229-40. 2008....
- Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptorsChristel Rousseaux
Institut National de la Santé et de la Recherche Médicale INSERM U795, Hôpital Swynghedauw, Rue A Verhaeghe, 59037 Lille Cedex, France
Nat Med 13:35-7. 2007..found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of ..
- Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applicationsEmmanuel S Onaivi
Department of Biology, William Paterson University, Wayne, New Jersey 07470, USA
Int Rev Neurobiol 88:335-69. 2009..Thus, understanding the ECS in the human body and brain will contribute to elucidating this natural regulatory mechanism in health and disease...
- Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligandsV M Showalter
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
J Pharmacol Exp Ther 278:989-99. 1996Two cannabinoid receptors have been identified to date; one is located predominantly in the central nervous system (CB1), whereas the other is located exclusively in the periphery (CB2)...
- Cannabinoid physiology and pharmacology: 30 years of progressAllyn C Howlett
Neuroscience of Drug Abuse Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
Neuropharmacology 47:345-58. 2004..One very important role for CB1 antagonists will be in the treatment of craving in the disease of substance abuse...
- Fatty acid amide hydrolase deficiency limits early pregnancy eventsHaibin Wang
Department of Pediatrics, Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Clin Invest 116:2122-31. 2006..This study uncovers what we believe to be a novel regulation of preimplantation processes, which could be clinically relevant for fertility regulation in women...
- The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptorsMélina Dani
Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, 3840 rue St Urbain, Montreal, H2W 1T8, Quebec, Canada
Eur J Pharmacol 573:214-5. 2007..These effects were inhibited by the administration of cannabinoid CB(1) (AM251) and CB(2) (AM630) receptor antagonists. The participation of the peripheral cannabinoid system in paracetamol analgesia is suggested...
- Tuning the oviduct to the anandamide toneHerbert Schuel
Division of Anatomy and Cell Biology, Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
J Clin Invest 116:2087-90. 2006..Anandamide (N-arachidonoylethanolamide) is a lipid signal molecule that was the first endogenous agonist for cannabinoid receptors to be discovered...
- Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamideP M Zygmunt
Department of Clinical Pharmacology, Institute of Laboratory Medicine, University of Lund, Sweden
Nature 400:452-7. 1999..The vanilloid receptor may thus be another molecular target for endogenous anandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.
- The endogenous cannabinoid system controls extinction of aversive memoriesGiovanni Marsicano
Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Nature 418:530-4. 2002..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala...
- Functions of cannabinoid receptors in the hippocampusS N Davies
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
Neuropharmacology 42:993-1007. 2002..to review the effects of cannabinoids on hippocampal function and evaluate the evidence that hippocampal cannabinoid receptors play a role in learning and formation of memory...
- N-Acylethanolamines in human reproductive fluidsHerbert Schuel
Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
Chem Phys Lipids 121:211-27. 2002..AEA is an endogenous agonist (endocannabinoid) for cannabinoid receptors. It binds with higher affinity to type CB1 than to type CB2 cannabinoid receptors...
- Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cellsCatherine Lombard
Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
Leuk Res 29:915-22. 2005Targeting cannabinoid receptors has recently been shown to trigger apoptosis and offers a novel treatment modality against malignancies of the immune system...
- Role of dorsal hippocampal cannabinoid receptors and nitric oxide in anxiety like behaviours in rats using the elevated plus-maze testAli Roohbakhsh
Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Clin Exp Pharmacol Physiol 34:223-9. 2007..4. These data imply that cannabinoids may have anxiogenic-like effects in the CA1 region of the hippocampus in which CB1 receptors and NO may be involved...
- Therapeutic action of cannabinoids in a murine model of multiple sclerosisAngel Arevalo-Martin
Neuroimmunology Group, Neural Plasticity Department, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
J Neurosci 23:2511-6. 2003....
- Cannabinoid receptors and the regulation of immune responseE V Berdyshev
The Hormel Institute, University of Minnesota, 801 16th Avenue N E, Austin, MN 55912, USA
Chem Phys Lipids 108:169-90. 2000..This progress was made possible by the discovery of cannabinoid receptors and the endogenous ligands for these receptors...
- Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoidsM C Beinfeld
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Neurosci Lett 301:69-71. 2001..CCK release from cerebral cortical slices was not altered by WIN+...
- Molecular biology of cannabinoid receptorsBeat Lutz
Group Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
Prostaglandins Leukot Essent Fatty Acids 66:123-42. 2002During the last decade, research on the molecular biology and genetics of cannabinoid receptors has led to a remarkable progress in understanding of the endogenous cannabinoid system, which functions in a plethora of physiological ..
- Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled studyAndre J Scheen
Division of Diabetes, Nutrition and Metabolic Disorders, CHU Sart Tilman, University of Liege, Liege, Belgium
Lancet 368:1660-72. 2006..The aim of the RIO-Diabetes trial was to assess the efficacy and safety of rimonabant in overweight or obese patients with type 2 diabetes that was inadequately controlled by metformin or sulphonylureas...
- CB1 cannabinoid receptors and on-demand defense against excitotoxicityGiovanni Marsicano
Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
Science 302:84-8. 2003..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
- Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein alpha-subunits with different potenciesP L Prather
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Mol Pharmacol 57:1000-10. 2000Previous studies had shown that the amplification factors for cannabinoid receptors, defined as the number of total G proteins activated per occupied receptor, differs between several rat brain regions...
- A computational study on cannabinoid receptors and potent bioactive cannabinoid ligands: homology modeling, docking, de novo drug design and molecular dynamics analysisSerdar Durdagi
Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, 48 Vas Constantinou Avenue, 11635, Athens, Greece
Mol Divers 14:257-76. 2010..The binding sites of receptors derived by rhodopsin-based models have been regenerated using the beta2-adrenergic based template receptors. The re-obtained models confirmed the ligand-binding pockets that were derived based on rhodopsin...
- Novel endogenous peptide agonists of cannabinoid receptorsIvone Gomes
Department of Pharmacology and Systems Therapeutics, Mt Sinai School of Medicine, New York, NY 10029, USA
FASEB J 23:3020-9. 2009..Taken together, these results suggest that the CB(1) receptor is involved in the integration of signals from both lipid- and peptide-derived signaling molecules...
- Cannabinoid receptors as therapeutic targets in the management of liver diseasesAriane Mallat
INSERM, Service d Hepatologie, Hospital Henri Moudor, Creteil, France
Drug News Perspect 21:363-8. 2008..Over the past decades, cannabinoid receptors have emerged as critical mediators of acute and chronic liver injury, and pharmacological modulation of ..
- Cannabinoid receptors and their endogenous agonistsC C Felder
Neuroscience Discovery, ELI LILLY RESEARCH LABORATORY, Indianapolis, Indiana 46285, USA
Annu Rev Pharmacol Toxicol 38:179-200. 1998..of novel agonists and antagonists with receptor subtype selectivity, mice with genetic deletion of the cannabinoid receptors, and receptor-specific antibodies, which should help in providing a better understanding of the ..
- Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptorsF Petitet
Rhone Poulenc Rorer S A, C R V A, Vitry sur Seine, France
Life Sci 63:PL1-6. 1998..Moreover at high concentration delta9-THC exhibits antagonist properties. Cannabinol is a weak agonist on rat cerebellar cannabinoid receptors and cannabidiol behaves as an antagonist acting in the micromolar range.
- Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusionA V Krylatov
Institute of Cardiology, Tomsk Scientific Center, Siberian Division of Russian Academy of Medical Sciences
Bull Exp Biol Med 131:523-5. 2001..These findings suggest that antiarrhythmic effect of HU-210 is mediated through activation of type II cannabinoid receptors rather than activation of K(+)-channels.
- Effects of acute systemic and intra-cerebral stimulation of cannabinoid receptors on sensorimotor gating, locomotion and spatial memory in ratsNico Wegener
Brain Research Institute, Department of Neuropharmacology, University of Bremen, P O Box 330440, 28334 Bremen, Germany
Psychopharmacology (Berl) 198:375-85. 2008..They mediate neuronal effects of their ligands in various corticolimbic and striatal circuits by presynaptic regulation of transmitter release...
- Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cellAlexander Korzh
The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Brain Res 1189:23-32. 2008..phosphorylation of ERK by a similar mechanism that involved activation of delta-opioid receptors or CB1 cannabinoid receptors coupled to Gi/Go proteins, matrix metalloproteases, vascular endothelial growth factor (VEGF) receptors ..
- Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic diseaseRobert J McKallip
Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
Blood 100:627-34. 2002..Together, the current data demonstrate that CB2 cannabinoid receptors expressed on malignancies of the immune system may serve as potential targets for the induction of ..
- Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's diseaseSusan H Fox
Manchester Movement Disorder Laboratory, Division of Neuroscience, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
Mov Disord 17:1180-7. 2002..e., levodopa-induced dyskinesia. Cannabinoid receptors are concentrated in the basal ganglia, and stimulation of cannabinoid receptors can increase gamma-..
- Endocannabinoid signaling in the brainRachel I Wilson
Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA
Science 296:678-82. 2002..Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism...
- Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa ratsMagali Gary Bobo
Sanofi Aventis Recherche and Développement, Discovery Research CNS Department, Montpellier, France
Hepatology 46:122-9. 2007....
- Cannabinoid receptors and painR G Pertwee
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
Prog Neurobiol 63:569-611. 2001..The existence of endogenous ligands for cannabinoid receptors has also been demonstrated...
- CB2 cannabinoid receptor-mediated peripheral antinociceptionT P Malan
Department of Anesthesiology and Pharmacology, University of Arizona, Tucson, AZ 85724, USA
Pain 93:239-45. 2001..Peripheral antinociception without CNS effects is consistent with the peripheral distribution of CB(2) receptors. CB(2) receptor agonists may have promise clinically for the treatment of pain without CNS cannabinoid side effects...
- Signal transduction activated by cannabinoid receptorsInés Díaz-Laviada
Departamento de Bioquímica y Biología Molecula, Facultad de Medicina, Universidad de Alcala, Madrid, Spain
Mini Rev Med Chem 5:619-30. 2005..Two types of cannabinoid receptors have been identified to date: CB(1) and CB(2) both belonging to the heptahelichoidal receptor family but ..
- Cannabinoid addiction: behavioral models and neural correlatesRafael Maldonado
Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
J Neurosci 22:3326-31. 2002..Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., 2000; Schlicker and Kathmann, 2001)...
- Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptorLaszlo Offertaler
Laboratory of Physiologic Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland, USA
Mol Pharmacol 63:699-705. 2003....
- The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalisMaurice R Elphick
School of Biological Sciences, Queen Mary, University of London, E1 4NS, London, UK
Gene 302:95-101. 2003The G-protein coupled cannabinoid receptors CB(1) and CB(2) are activated by Delta(9)-tetrahydrocannabinol, the psychoactive ingredient of cannabis, and mediate physiological effects of endogenous cannabinoids ('endocannabinoids')...
- Effect of cannabinoids on neural transmission in rat gastric fundusM Storr
Department of Internal Medicine II, Technical University of Munich, Germany
Can J Physiol Pharmacol 80:67-76. 2002..The involved cannabinoid receptors are most likely located on neuronal structures...
- The gastrointestinal pharmacology of cannabinoidsA A Izzo
Department of Experimental Pharmacology, University of Naples Federico II, Italy
Curr Opin Pharmacol 1:597-603. 2001..Activation of CB1 receptors inhibits gastrointestinal motility, intestinal secretion and gastric acid secretion. The enteric location of CB1 receptors could provide new strategies for the management of gut disorders...
- Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tractMaria Antonietta Casu
Neuroscienze Scarl, Via Palabanda, 9 09124-I, Cagliari, Italy
Eur J Pharmacol 459:97-105. 2003..Moreover, the dose of 0.3 microg/kg of HU 210, devoid per se of any activity on mouse intestinal propulsion, blocked the increased gastroenteric transit induced by the cannabinoid CB(1) antagonist SR 141716A...
- Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoidKrista Laine
Departments of Pharmaceutical Chemistry, University of Kuopio, Finland
Invest Ophthalmol Vis Sci 43:3216-22. 2002..In the present study, both the degradation of endogenous cannabinoids in ocular tissues and the effect on IOP of 2-AG and noladin ether were compared...
- The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cellsVardit Rubovitch
The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
Brain Res Mol Brain Res 101:93-102. 2002..Hence, we suggest a cannabinoid-specific, PTX-insensitive, stimulatory effect on L-type voltage-dependent calcium channels, which is mediated by PKA and modulated by PKC and calmodulin...
- Evidence for novel cannabinoid receptorsMalcolm Begg
National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC-9413 Bethesda, MD 8092-9413, United States
Pharmacol Ther 106:133-45. 2005..To date, two G protein-coupled cannabinoid receptors have been identified by molecular cloning, CB1 receptors mainly expressed in the brain and mediating most ..
- Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistryK Tsou
Department of Psychology, Brown University, Providence, RI 02912, USA
Neurosci Lett 254:137-40. 1998..These data demonstrate that FAAH is heterogeneously distributed and this distribution exhibits considerable, although not complete, overlap with the distribution of cannabinoid CB1 receptors in rat brain...
- GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M currentJane E Lauckner
Departments of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 105:2699-704. 2008..GPR55 activation also inhibits M current. These results establish GPR55 as a cannabinoid receptor with signaling distinct from CB(1) and CB(2)...
- Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trialF Xavier Pi-Sunyer
Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
JAMA 295:761-75. 2006..Rimonabant, a selective cannabinoid-1 receptor blocker, may reduce body weight and improve cardiometabolic risk factors in patients who are overweight or obese...
- Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic painSomsak Mitrirattanakul
Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA 90095, USA
Pain 126:102-14. 2006....
- Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondriaWentao Jia
Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
Mol Cancer Res 4:549-62. 2006..Together, these data suggested that Raf-1/MEK/ERK/RSK-mediated Bad translocation played a critical role in THC-induced apoptosis in Jurkat cells...
- Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioningP Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892 9413, USA
Br J Pharmacol 153:252-62. 2008....
- The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in ratsA A Izzo
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
Eur J Pharmacol 384:37-42. 1999....
- [Characteristics of abnormal behavior induced by delta 9-tetrahydrocannabinol in rats]M Fujiwara
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jounan Ku, Fukuoka 814 0180, Japan
Nihon Yakurigaku Zasshi 117:35-41. 2001..Thus the abnormal behavior induced by THC can be a useful model for investigating mental function in humans and new drugs for the treatment of mental disorders...
- Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell deathAndriani Athanasiou
School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
Biochem Biophys Res Commun 364:131-7. 2007..These data demonstrate that AEA, THC, and HU 210 are all able to cause changes in integrated mitochondrial function, directly, in the absence of cannabinoid receptors.
- Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbensD Robbe
, 34094 Montpellier Cedex 05, France
J Neurosci 21:109-16. 2001..to the nucleus accumbens (NAc) in the actions of most drugs of abuse, the presence and functions of cannabinoid receptors (CB1) on the glutamatergic cortical afferents to the NAc have never been explored...
- Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placentaS P Kenney
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, USA
Am J Obstet Gynecol 181:491-7. 1999We sought to investigate the expression of cannabinoid receptors in human placenta and BeWo choriocarcinoma cells and study their role in the regulation of the serotonin transporter.
- N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory propertiesGarry Milman
Department of Medicinal Chemistry and Natural Products, Medical Faculty, and Laboratory of Environmental Physiology, Faculty of Dental Medicine, Hebrew University, Jerusalem 91120, Israel
Proc Natl Acad Sci U S A 103:2428-33. 2006..Many of these effects parallel those reported for abnormal cannabidiol (Abn-CBD), a synthetic agonist of a putative novel cannabinoid-type receptor. Hence, ARA-S may represent an endogenous agonist for this receptor...
- Cannabinoid receptors on goldfish retinal bipolar cells: electron-microscope immunocytochemistry and whole-cell recordingsS Yazulla
Department of Neurobiology and Behavior, University at Stony Brook, NY 11794 5230, USA
Vis Neurosci 17:391-401. 2000..Inhibition of I(K(V)) in the Mb bipolar cells by cannabinoids should result in a more tonic ON response to increments of light. As such, cannabinoids may play a role in modulating the temporal aspects of signaling in the retina...
- Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptorsSandra Holt
Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden
Br J Pharmacol 146:467-76. 2005..In conclusion, the results show that in mice, treatment with indomethacin and URB597 produce SR144528-sensitive anti-inflammatory effects in the carrageenan model of acute inflammation...
- Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune systemA R Schatz
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, USA
Toxicol Appl Pharmacol 142:278-87. 1997..Collectively, these results provide further evidence that CB2 is the predominant cannabinoid receptor within the immune system and that this form of the receptor is expressed on T cells...
- Cannabinoid receptors undergo axonal flow in sensory nervesA G Hohmann
Section on Functional Neuroanatomy, National Institute of Mental Health, Bethesda, MD 20892 4070, USA
Neuroscience 92:1171-5. 1999..The present study was conducted to evaluate axonal flow of cannabinoid receptors from the dorsal root ganglion to the periphery and to identify the putative involvement of CB1 and/or CB2 ..
- The orphan receptor GPR55 is a novel cannabinoid receptorE Ryberg
Department of Lead Generation, AstraZeneca R and D, Molndal, Sweden
Br J Pharmacol 152:1092-101. 2007..Work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in a number of physiological processes...
- Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoidsKenneth Ihenetu
Department of Biosciences, CP Snow Building, University of Hertfordshire, Hatfield Campus, College Lane, Hertfordshire AL10 9AB, Hatfield, UK
Eur J Pharmacol 458:207-15. 2003..We conclude that in HT-29 cells, TNF-alpha-induced interleukin-8 release is inhibited by cannabinoids through activation of cannabinoid CB(2) receptors...
- Modulation of anxiety through blockade of anandamide hydrolysisSatish Kathuria
Department of Pharmacology, University of California, Irvine, California, USA
Nat Med 9:76-81. 2003..of cannabis, Delta(9)-tetrahydrocannabinol, produces in humans subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous cannabinoids may contribute to the control of emotion...
- R+-methanandamide inhibits tracheal response to endogenously released acetylcholine via capsazepine-sensitive receptorsPaola Nieri
Department of Psychiatry, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy
Eur J Pharmacol 459:75-81. 2003....
- Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampusJimok Kim
Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 22:10182-91. 2002..This study reveals a new role of the muscarinic cholinergic system in mammalian brain...
- Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716Suzanne Higgs
School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Psychopharmacology (Berl) 165:370-7. 2003..The motivational changes underlying these actions remain to be determined, but may involve alterations to food palatability...
- Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in miceLei Wang
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:1393-8. 2003....
- Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptorEster Fride
Department of Behavioral Sciences, College of Judea and Samaria, Ariel 44837, Israel
Eur J Pharmacol 461:27-34. 2003..We have reported previously that cannabinoid receptors play a critical role during the early suckling period: The selective cannabinoid CB(1) receptor antagonist ..
- Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellumAnatol C Kreitzer
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Neuron 34:787-96. 2002..Because interneurons can project over several hundred micrometers, this inhibition of firing allows cells to regulate synaptic inputs at distances well beyond the limits of endocannabinoid diffusion...
- Neuroscience. Stout guards of the central nervous systemR Mechoulam
Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel
Science 302:65-7. 2003..showing that activation of the cannabinoid receptor CB1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy...
- Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin testMyung Ha Yoon
Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwanju, Korea
Anesthesiology 99:701-7. 2003....
- Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neuronsRobert E Hampson
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
Hippocampus 13:543-56. 2003....
- Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampusAlexander F Hoffman
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Eur J Neurosci 18:524-34. 2003..Whereas activation of cannabinoid receptors via the application of the cannabinoid agonist WIN55,212-2 significantly and dose-dependently reduced ..
- Modulation of electrically evoked acetylcholine release through cannabinoid CB1 receptors: evidence for an endocannabinoid tone in the human neocortexM Steffens
, Neurozentrum, Breisacherstrasse 64, D-79106 Freiburg, Germany
Neuroscience 120:455-65. 2003..The results show that activation of CB1 cannabinoid receptors leads to inhibition of ACh release in the human and mouse neocortex...
- Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonateIsabel Lastres-Becker
URA CEA CNRS 2210, , DRM, DSV, CEA, , 91401-Orsay Cedex, France
Neuroreport 14:813-6. 2003....
- Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposureAlexander F Hoffman
Cellular Neurobiology Branch, Section on Cellular Neurophysiology, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 23:4815-20. 2003..These data demonstrate that long-term exposure to the active ingredient of marijuana blocks synaptic plasticity in the NAc and reduces the sensitivity of GABAergic and glutamatergic synapses to both cannabinoids and opioids...
- Neuroprotection by the cannabinoid agonist WIN-55212 in an in vivo newborn rat model of acute severe asphyxiaJose Martinez-Orgado
Area de Pediatría y Neonatología, Fundacion Hospital Alcorcon, Avda Budapest 1, 28990 Alcorcón, Madrid, Spain
Brain Res Mol Brain Res 114:132-9. 2003..This effect is achieved through two parallel CB1-dependent and -independent mechanisms...
- Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitroJatinder Ahluwalia
Department of Academic Anaesthetics, Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK
Eur J Neurosci 17:2611-8. 2003..These findings also suggest that anandamide could be one of the molecules responsible for the development of inflammatory heat hyperalgesia...
- Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytesAmruthesh C Shivachar
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
Biochem Pharmacol 73:2004-11. 2007..These results suggest that cannabinoids and endocannabinoids may constitute a novel class of inhibitors of astroglial glutamate transport system...
- Effects of cannabinoid receptor agonists on immunologically induced histamine release from rat peritoneal mast cellsAlaster H Y Lau
Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Basic Medical Sciences Building, Shatin, New Territories, China
Eur J Pharmacol 464:229-35. 2003..However, more recent studies produced contradicting results. In order to evaluate if cannabinoid receptors are present in mast cells, we studied the effects of endocannabinoids (anandamide and ..
- Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heartJean Francois Bouchard
Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
Life Sci 72:1859-70. 2003..In conclusion, the data suggest that endogenous cannabinoids contribute to the endothelial protective effect of ischemic preconditioning in rat coronary arteries...
- Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicityReeti Katoch-Rouse
Neuroimaging Research Branch and Cellular Neurophysiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Med Chem 46:642-5. 2003Exploration of the central CB1 cannabinoid receptors using positron emission tomography (PET) will allow for an understanding of the pharmacological and physiological role played by these receptors in the CNS...
- A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feedingRaquel Gomez
University Institute of Drug Dependencies, Department of Psychobiology, University Complutense of Madrid, Madrid 28223, Spain
J Neurosci 22:9612-7. 2002..Pretreatment with SR141716A enhanced the inhibition of feeding induced by intraperitoneal administration of oleoylethanolamide. The results reveal an unexpected role for peripheral CB1 receptors in the regulation of feeding...
- Cannabinoids inhibit the formation of new synapses between hippocampal neurons in cultureD Kim
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455-0217, USA
J Neurosci 21:RC146. 2001..Thus, activation of cannabinoid receptors can modulate synaptic plasticity independent of direct effects on neurotransmitter release...
- Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferretM D Van Sickle
Neuroscience and Gastrointestinal Research Groups, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Gastroenterology 121:767-74. 2001..CONCLUSIONS: CB1r mediates the anti-emetic action of cannabinoids in the dorsal vagal complex. Endocannabinoids are a novel neuroregulatory system involved in the control of emesis...
- Exogenous anandamide protects rat brain against acute neuronal injury in vivoM van der Stelt
Department of Bio-Organic Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH Utrecht, The Netherlands
J Neurosci 21:8765-71. 2001..Although our data seem to question a possible role of the endogenous cannabinoid system in establishing a brain defense system in our model, AEA may be used as a structural template to develop neuroprotective agents...
- Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptorsZ Jarai
Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
Proc Natl Acad Sci U S A 96:14136-41. 1999..Two cannabinoid receptors, CB1 and CB2, have been cloned, and studies with the selective CB1 receptor antagonist SR141716A have ..
- Metabotropic glutamate receptors drive the endocannabinoid system in hippocampusN Varma
Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 21:RC188. 2001..DSI is produced when an endocannabinoid released from pyramidal cells suppresses IPSCs by activating CB1R cannabinoid receptors located on inhibitory interneurons...
- The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoidsNissar A Darmani
Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, Missouri 63501, USA
J Pharmacol Exp Ther 300:34-42. 2002....
- Short-term retrograde inhibition of GABAergic synaptic currents in rat Purkinje cells is mediated by endogenous cannabinoidsMarco A Diana
, , 75006 Paris, France
J Neurosci 22:200-8. 2002..Here we show that, in cerebellar parasagittal slices, type 1 cannabinoid receptors (CB1Rs) are expressed at high levels in axons of GABAergic interneurons and in presynaptic terminals onto ..
- Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effectsM J Wallace
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0599, USA
Eur J Pharmacol 428:51-7. 2001..This study establishes a role for the cannabinoid CB1 receptor in modulating seizure activity in a whole animal model...
- CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cordI J Lever
Neuroscience Research Centre, Guy's King's and St. Thomas' School of Biomedical Sciences, King's College London, London, SE1 1UL
Br J Pharmacol 135:21-4. 2002..We have investigated a possible modulatory role for Type 1 Cannabinoid receptors (CB(1)) on the release of excitatory transmitter Substance P from the adult mouse spinal cord after ..
- Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the ratSilvia Conti
Department of Biotechnology and Bioscience, Faculty of Sciences, University of Milan-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Br J Pharmacol 135:181-7. 2002..6. Our findings show the antiinflammatory effect of nabilone and confirm that of palmitoylethanolamide indicating that these actions are mediated by an uncharacterized CB(2)-like cannabinoid receptor...
- R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanismR Ramer
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, Erlangen, D-91054, Germany
Biochem Biophys Res Commun 286:1144-52. 2001..In conclusion, induction of COX-2 expression may represent a novel mechanism by which cannabinoids mediate PG-dependent effects within the central nervous system...
- CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatumG Gerdeman
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212-0615, USA
J Neurophysiol 85:468-71. 2001CB1 cannabinoid receptors in the neostriatum mediate profound motor deficits induced when cannabinoid drugs are administered to rodents...
- Leptin-regulated endocannabinoids are involved in maintaining food intakeV Di Marzo
Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072, Arco Felice, Naples, Italy
Nature 410:822-5. 2001..However, alternative orexigenic pathways maintain food intake in mice deficient in neuropeptide Y. CB1 cannabinoid receptors and the endocannabinoids anandamide and 2-arachidonoyl glycerol are present in the hypothalamus, and ..
- The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic painD Bridges
Pain Research, Imperial College School of Medicine, Chelsea and Westminster Hospital Campus, London, SW10 9NH
Br J Pharmacol 133:586-94. 2001..These data indicate that cannabinoids may have therapeutic potential in neuropathic pain, and that this effect is mediated through the CB(1) receptor...
- Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptorsJ A Wagner
Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond, VA 23298, USA
Eur J Pharmacol 423:203-10. 2001..Differences between the hemodynamic profile of various cannabinoids may reflect quantitative differences in cannabinoid CB(1) receptor expression in different tissues and/or the involvement of as-yet-unidentified receptors...
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMichael Camilleri; Fiscal Year: 2009..b>Cannabinoid receptors (CBR) are on cholinergic neurons in the brain stem, stomach and colon...
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2009..The eCB system consists of two endogenous cannabinoid receptors, CB1 and CB2...
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2010..The eCB system consists of two endogenous cannabinoid receptors, CB1 and CB2...
- Protective Effects of Cannabinoids in HIV NeuropathogenesisROBERT BRYAN ROCK; Fiscal Year: 2010..little is known about the effects of cannabinoids on HIV-1 neuropathogenesis, despite the facts that cannabinoid receptors are abundantly expressed in the striatum and that the nigrostriatal dopaminergic area is highly ..
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMICHAEL L CAMILLERI; Fiscal Year: 2010..b>Cannabinoid receptors (CBR) are on cholinergic neurons in the brain stem, stomach and colon...
- Role of Endocannabinoids in Levodopa-Induced DyskinesiasAndrea Giuffrida; Fiscal Year: 2007..little attention to the endocannabinoid neurotransmitter system, despite: (1) the striking abundance of cannabinoid receptors in the basal ganglia; (2) functional interactions between endocannabinoids and neurotransmitters that ..
- Opioids,Cannabinoids,Chemokines:Neuroimmune InteractionsMartin Adler; Fiscal Year: 2006..Mu, kappa, and delta opioid receptors and CB1 and CB2 cannabinoid receptors have been demonstrated in the immune system...
- ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACHAndrea Hohmann; Fiscal Year: 2007..Newly- released 2-AG engages local cannabinoid receptors to induce nonopioid SIA, and is then subsequently deactivated through monoacylglycerol lipase (MGL)-..
- MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODELCLARA SANUDO PENA; Fiscal Year: 2002..The recent cloning and mapping of a nervous cannabinoid receptor unveiled high levels of cannabinoid receptors in the basal ganglia where they are as abundant as the receptors for dopamine...
- Role of Endocannabinoids in Levodopa-Induced DyskinesiasAndrea Giuffrida; Fiscal Year: 2009..little attention to the endocannabinoid neurotransmitter system, despite: (1) the striking abundance of cannabinoid receptors in the basal ganglia; (2) its ability to regulate basal ganglia function; (3) experimental evidence for ..
- Control of Breast Cancer by the Endocannabinoid SystemSean McAllister; Fiscal Year: 2007..tonically inhibits metastatic breast cancer cell proliferation and invasiveness through the activation of cannabinoid receptors. Our preliminary data also suggests that cannabinoid compounds possess selective efficacy, having less ..
- MARIJUANA EFFECTS ON IMMUNITY--NATURE AND MECHANISMSHerman Friedman; Fiscal Year: 2001..we have developed the hypothesis that cannabinoids depress immunity to infection by acting through cannabinoid receptors (CBR) and causing an imbalance in the immune cytokine network leading to a functional depression in cell-..
- CANNABINOID MODULATION OF HYPERALGESIADonald A Simone; Fiscal Year: 2010..b>Cannabinoid receptors (CB1 and CB2) are located in the periphery, as well as the central nervous system, and modulate ..
- ENDOGENOUS CANNABINOIDS AND BRAIN/IMMUNE FUNCTIONBilly Martin; Fiscal Year: 2006..We are now assured that endocannabinoids produce some of their effects through known cannabinoid receptors, yet they are also capable of acting at as-yet-unidentified sites...
- REPRESSION OF T CELL ACTIVATION BY ENDOCANNABINOIDSNorbert Kaminski; Fiscal Year: 2003The overall goals of this 4 year research plan are two-fold: (a) to characterize the role of cannabinoid receptors CB1 and CB2 in the modulation of T-cell function by endogenous eicosinoid-like cannabinoids; and (b) to elucidate the ..
- MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDSAndrew Gifford; Fiscal Year: 2002..The active ingredient of marijuana, delta 9THC, acts on specific receptors, termed cannabinoid receptors, which are abundantly expressed in many regions of the brain...
- Cannabinoid Receptors and Cerebrovascular FunctionCecilia Hillard; Fiscal Year: 2006..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
- ELECTROPHYSIOLOGICAL ASSESSMENT OF CANNABINOID RECEPTORSSAMUEL DEADWYLER; Fiscal Year: 1999..application of a research program in its third year of electrophysiological assessment of the role of cannabinoid receptors in brain. In the first 2...
- fMRI and Cognition in Adolescent Cannabis UsersSusan Tapert; Fiscal Year: 2007..form of gray matter decreases and white matter increases, including in regions with dense distributions of cannabinoid receptors (e.g., frontal lobe, hippocampus, striatum, and cerebellum)...
- fMRI and Cognition in Adolescent Cannabis UsersSusan Tapert; Fiscal Year: 2009..form of gray matter decreases and white matter increases, including in regions with dense distributions of cannabinoid receptors (e.g., frontal lobe, hippocampus, striatum, and cerebellum)...