calcitonin receptors

Summary

Summary: Cell surface proteins that bind calcitonin and trigger intracellular changes which influence the behavior of cells. Calcitonin receptors outside the nervous system mediate the role of calcitonin in calcium homeostasis. The role of calcitonin receptors in the brain is not well understood.

Top Publications

  1. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
  2. ncbi International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
    David R Poyner
    Pharmaceutical Sciences Institute, Aston University, Birmingham, United Kingdom
    Pharmacol Rev 54:233-46. 2002
  3. ncbi Novel receptor partners and function of receptor activity-modifying proteins
    Arthur Christopoulos
    Department of Pharmacology and the Howard Florey Institute, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:3293-7. 2003
  4. ncbi Immunohistochemical expression of glucocorticoid and calcitonin receptors as a tool for selecting therapeutic approach in central giant cell granuloma of the jawbones
    M Vered
    Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Oral Maxillofac Surg 35:756-60. 2006
  5. ncbi Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor
    Maoqing Dong
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 279:1167-75. 2004
  6. ncbi A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors
    Alex C Conner
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Mol Pharmacol 67:20-31. 2005
  7. ncbi Molecular signature of quiescent satellite cells in adult skeletal muscle
    So ichiro Fukada
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Stem Cells 25:2448-59. 2007
  8. ncbi Calcitonin-induced change in serum calcium levels and its relationship to osteoclast morphology and number of calcitonin receptors
    Mika Ikegame
    Division of Oral Morphology, Science of Functional Recovery and Reconstruction, Okayama Graduate School of Medicine and Dentistry, Shikata cho, Japan
    Bone 35:27-33. 2004
  9. pmc Calcitonin and calcitonin receptors: bone and beyond
    M Pondel
    Department of Cellular Pathology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Int J Exp Pathol 81:405-22. 2000
  10. ncbi Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1
    Graeme S Cottrell
    Department of Surgery, University of California, San Francisco, California 94143 0660, USA
    J Biol Chem 282:12260-71. 2007

Research Grants

  1. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2010
  2. Adrenomedullin Signaling at the Maternal-Fetal Interface
    Kathleen Caron; Fiscal Year: 2009
  3. Adrenomedullin Signaling at the Maternal-Fetal Interface
    Kathleen M Caron; Fiscal Year: 2010
  4. CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERS
    Philip Osdoby; Fiscal Year: 2002
  5. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
  6. CALCITONIN RECEPTOR GENE EXPRESSION
    Steven Goldring; Fiscal Year: 2002
  7. Role of RAMPs in Intermedin Signaling
    Sheau Yu Hsu; Fiscal Year: 2009
  8. Role of RAMPs in Intermedin Signaling
    Sheau Yu Teddy Hsu; Fiscal Year: 2010
  9. Adrenomedullin Signaling in Vascular Development
    Kathleen M Caron; Fiscal Year: 2010
  10. Characterization of Neuroendocrine CGRP Receptors
    Ian Dickerson; Fiscal Year: 2006

Detail Information

Publications188 found, 100 shown here

  1. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
    ..RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors...
  2. ncbi International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
    David R Poyner
    Pharmaceutical Sciences Institute, Aston University, Birmingham, United Kingdom
    Pharmacol Rev 54:233-46. 2002
    ..Recommendations, which follow International Union of Pharmacology guidelines, are made for the nomenclature of these multimeric receptors...
  3. ncbi Novel receptor partners and function of receptor activity-modifying proteins
    Arthur Christopoulos
    Department of Pharmacology and the Howard Florey Institute, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:3293-7. 2003
    ..Our findings identify a new functional consequence of RAMP-receptor interaction, suggesting that RAMPs play a more general role in modulating cell signaling through other GPCRs than is currently appreciated...
  4. ncbi Immunohistochemical expression of glucocorticoid and calcitonin receptors as a tool for selecting therapeutic approach in central giant cell granuloma of the jawbones
    M Vered
    Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Oral Maxillofac Surg 35:756-60. 2006
    ..a practical tool, based on the relative percentage of positively stained cells for glucocorticoid and/or calcitonin receptors, for selecting the appropriate therapeutic agents to treat CGCG...
  5. ncbi Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor
    Maoqing Dong
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 279:1167-75. 2004
    ..deglycosylation, specific chemical and enzymatic cleavage, and sequencing of labeled wild type and mutant calcitonin receptors identified the sites of labeling for the position 16 and 26 probes as receptor residues Phe137 and Thr30, ..
  6. ncbi A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors
    Alex C Conner
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Mol Pharmacol 67:20-31. 2005
    ..P321A-I325P, predicted to restore this conformation, showed wild-type activation. Modeling can also rationalize the effects of transmembrane proline mutants previously reported for another family B GPCR, the VPAC(1) receptor...
  7. ncbi Molecular signature of quiescent satellite cells in adult skeletal muscle
    So ichiro Fukada
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Stem Cells 25:2448-59. 2007
    ..Our data provide roles of CTR in quiescent satellite cells and a solid scaffold to further dissect molecular regulation of satellite cells. Disclosure of potential conflicts of interest is found at the end of this article...
  8. ncbi Calcitonin-induced change in serum calcium levels and its relationship to osteoclast morphology and number of calcitonin receptors
    Mika Ikegame
    Division of Oral Morphology, Science of Functional Recovery and Reconstruction, Okayama Graduate School of Medicine and Dentistry, Shikata cho, Japan
    Bone 35:27-33. 2004
    ..Furthermore, the reduced effectiveness of CT in response to repeated CT administration was found to be related to the downregulation of the CTRs on the osteoclast surface...
  9. pmc Calcitonin and calcitonin receptors: bone and beyond
    M Pondel
    Department of Cellular Pathology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Int J Exp Pathol 81:405-22. 2000
    ....
  10. ncbi Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1
    Graeme S Cottrell
    Department of Surgery, University of California, San Francisco, California 94143 0660, USA
    J Biol Chem 282:12260-71. 2007
    ..After sustained stimulation, CLR and RAMP1 traffic from endosomes to lysosomes by ubiquitin-independent mechanisms, where they are degraded at different rates...
  11. ncbi Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor
    Burcu Hasdemir
    Department of Surgery, University of California, San Francisco, California 94143 0660, USA
    J Biol Chem 282:29646-57. 2007
    ..The ultimate sorting decision to degradative or recycling pathways appears to occur downstream from HRS...
  12. ncbi Expression of the calcitonin receptor in bone marrow cell cultures and in bone: a specific marker of the differentiated osteoclast that is regulated by calcitonin
    S K Lee
    Department of Veterans Affairs Medical Center, Newington, Connecticut 06111, USA
    Endocrinology 136:4572-81. 1995
    ..Both MNCs that formed in bone marrow cultures and isolated primary osteoclasts formed resorption pits on bone slices.(ABSTRACT TRUNCATED AT 400 WORDS)..
  13. ncbi Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes
    B C Sondergaard
    Nordic Bioscience Diagnostics, Herlev, Denmark
    Osteoarthritis Cartilage 14:759-68. 2006
    ..We investigated direct effects of calcitonin on chondrocytes by assessing expression of the receptor and pharmacological effects on collagen type II degradation under ex vivo and in vivo conditions...
  14. ncbi Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea, Sweden
    J Musculoskelet Neuronal Interact 6:87-95. 2006
    ..Thus, our understanding of the role of the CT family of peptides has been changed dramatically and much more data have to be gained before we fully understand the roles these peptides have in bone biology...
  15. ncbi Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin
    S Hilairet
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
    J Biol Chem 276:42182-90. 2001
    ..These results therefore indicate that although atypical by its heterodimeric composition and its targeting to the plasma membrane, the CGRP receptor shares endocytotic mechanisms that are common to most classical 7TM receptors...
  16. ncbi Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat
    Graeme S Cottrell
    Department of Surgery, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0660, USA
    J Comp Neurol 490:239-55. 2005
    ....
  17. ncbi Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: the contributions of novel receptor-activity-modifying proteins
    W Born
    Research Laboratory for Calcium Metabolism, Departments of Orthopedic Surgery and Medicine, University of Zurich, Klinik Balgrist, Forchstr 340, 8008 Zurich, Switzerland
    Receptors Channels 8:201-9. 2002
    ..The same receptor is specific for adrenomedullin (ADM) in the presence of RAMP2. Calcitonin receptors (CTR) with 60% homology to the CRLR predominantly recognize calcitonin in the absence of RAMP...
  18. ncbi Evidence that human cartilage and chondrocytes do not express calcitonin receptor
    Z Lin
    Centre for Orthopaedic Research, School of Surgery and Pathology, University of Western Australia, Western Australia, Australia
    Osteoarthritis Cartilage 16:450-7. 2008
    ..In this study, we investigated the existence of CTR in human articular cartilage and chondrocytes, and examined the potential pharmacological effects and transduction pathway of salmon CT (sCT) in human chondrocytes...
  19. ncbi Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst differentiation by calcitonin
    J Wang
    Department of Obstetrics and Gynecology and Department of Anatomy and Cell Biology, C S Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201 1415, USA
    Development 125:4293-302. 1998
    ....
  20. ncbi Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation
    Jami Mandelin
    Institute of Biomedicine Anatomy, Biomedicum Helsinki, University of Helsinki, Finland
    J Biomed Mater Res B Appl Biomater 74:582-8. 2005
    ..It is thus concluded that suppression of RANKL activity may be beneficial in terms of increasing the lifetime of total hip prostheses...
  21. doi Structure-function analysis of RAMP1 by alanine mutagenesis
    John Simms
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochemistry 48:198-205. 2009
    ..The data are consistent with a CLR recognition site particularly involving Y66 and H97, with lesser roles for adjacent residues in helix 3. L69 and T73 may contribute to a CGRP recognition site in helix 2 also involving nearby residues...
  22. ncbi Osteoclast-derived activity in the coupling of bone formation to resorption
    T John Martin
    St Vincent s Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Trends Mol Med 11:76-81. 2005
    ..We argue that osteoclasts contribute in important ways to the transiently activated osteoclast, and stimulate osteoblast lineage cells to begin replacing the resorbed bone in each BMU...
  23. ncbi The extreme N-terminus of the calcitonin-like receptor contributes to the selective interaction with adrenomedullin or calcitonin gene-related peptide
    Daniela Koller
    Research Laboratory for Calcium Metabolism, Departments of Orthopaedic Surgery and Medicine, University of Zurich, Klinik Balgrist, Forchstrasse 340, 8008, Zurich, Switzerland
    FEBS Lett 531:464-8. 2002
    ..Limited sequence similarities in the N-terminus of the pCT and the hCL receptors rescue CGRP but not AM receptor binding and signalling...
  24. ncbi Molecular characterization of two novel isoforms of the human calcitonin receptor
    J Beaudreuil
    INSERM Unite 606, Centre Viggo Petersen, Hopital Lariboisiere, 6 rue Guy Patin, 75475 Paris Cedex 10, France
    Gene 343:143-51. 2004
    ..Our findings therefore indicate the existence of two novel splice variants of the H-CTR and confirm that multiple splicing patterns could be involved in the post-transcriptional regulation of the gene...
  25. ncbi Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity
    Takeshi Katafuchi
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita 565 8565, Osaka, Japan
    J Biol Chem 278:12046-54. 2003
    ..These unique properties indicate that CRSP is not a porcine counterpart of betaCGRP and probably elicits its biological effects via the calcitonin receptor...
  26. ncbi The N-terminal extracellular domain 23-60 of the calcitonin receptor-like receptor in chimeras with the parathyroid hormone receptor mediates association with receptor activity-modifying protein 1
    Lars M Ittner
    Research Laboratory for Calcium Metabolism, Department of Orthopedic Surgery, University of Zurich, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, Switzerland
    Biochemistry 44:5749-54. 2005
    ..Other chimeric CLR-PTHR were inactive. In conclusion, structural elements in the extreme N-terminus of the CLR between amino acids 23-60 are required and sufficient for CLR/RAMP1 cotransport to the plasma membrane and heterodimerization...
  27. ncbi Mutations of the asparagine117 residue of a receptor activity-modifying protein 1-dependent human calcitonin gene-related peptide receptor result in selective loss of function
    R Gujer
    Research Laboratory for Calcium Metabolism, Departments of Orthopedic Surgery and Medicine, University of Zurich, Klinik Balgrist, 8008 Zurich, Switzerland
    Biochemistry 40:5392-8. 2001
    ..Unlike Asn(60) and Asn(112), Asn(117) is normally not N-glycosylated, but essential for CGRP binding to the hCRLR-RAMP1 complex...
  28. ncbi An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3
    R Muff
    Department for Orthopedic Surgery, University of Zurich, Switzerland
    Endocrinology 140:2924-7. 1999
    ..In conclusion, RAMP1 and -3 decrease calcitonin receptor expression in RAEC transfected with hCTR2 encoding cDNA and simultanously reveal an amylin receptor...
  29. ncbi A new calcitonin-receptor-like sequence in rat pulmonary blood vessels
    F Njuki
    Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, U K
    Clin Sci (Lond) 85:385-8. 1993
    ..Both have binding activity in the lung and are potent vasodilators. The gene represented by this sequence may therefore play an important role in the maintenance of vascular tone...
  30. ncbi Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product
    G Christopoulos
    Molecular Pharmacology Laboratory, Department of Pharmacology, The University of Melbourne, Victoria, Australia
    Mol Pharmacol 56:235-42. 1999
    ....
  31. ncbi Cloning and characterization of an abundant subtype of the human calcitonin receptor
    R E Kuestner
    ZymoGenetics Inc, Seattle, Washington 98102
    Mol Pharmacol 46:246-55. 1994
    ..Lastly, by using a human/rodent somatic cell hybrid panel and in situ hybridization, we localized the human calcitonin receptor gene to chromosome 7...
  32. ncbi Calcitonin
    P M Sexton
    Molecular Pharmacology Unit, Department of Pharmacology, The University of Melbourne, Victoria, Parkville 3052, Australia
    Curr Med Chem 6:1067-93. 1999
    ..Finally, current therapeutic use is reviewed, and the potential for expanded use that may come with advances in delivery of peptides or CT mimetics...
  33. pmc Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding
    Sugato Banerjee
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202 9037, USA
    BMC Pharmacol 6:9. 2006
    ..Therefore, we hypothesize that hydrophobic amino acids within the previously characterized 18 amino acid CLR N-terminus domain are important binding contacts for the C-terminal phenylalaninamide of CGRP...
  34. ncbi Identification and pharmacological characterization of domains involved in binding of CGRP receptor antagonists to the calcitonin-like receptor
    Christopher A Salvatore
    Pain Research Department, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Biochemistry 45:1881-7. 2006
    ..Collectively, these data provide insight into two alternative mechanisms of antagonism for this unique heterodimeric receptor complex...
  35. ncbi Human calcitonin receptor-like receptor for adrenomedullin: genomic structure, eight single-nucleotide polymorphisms, and haplotype analysis
    I Nakazawa
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
    J Hum Genet 46:132-6. 2001
    ..The data establish a basis for investigations to detect molecular variants in the ADM receptor that might alter control of blood pressure and confer on individuals a predisposition to essential hypertension...
  36. pmc Crystal structure of the human receptor activity-modifying protein 1 extracellular domain
    Seisuke Kusano
    RIKEN Systems and Structural Biology Center, Yokohama 230 0045, Japan
    Protein Sci 17:1907-14. 2008
    ..These results suggest that the hydrophobic patch participates in the interaction with CRLR and the formation of the ligand-binding pocket when it forms the CRLR.RAMP1 heterodimer...
  37. ncbi A human orphan calcitonin receptor-like structure
    B Fluhmann
    Department of Orthopaedic Surgery, University of Zurich, Switzerland
    Biochem Biophys Res Commun 206:341-7. 1995
    ..The receptor-like protein whose ligand remains to be discovered belongs to the family of receptors of calcitonin, parathyroid hormone, secretin, vasointestinal peptide and pituitary adenylate cyclase-activating polypeptide...
  38. ncbi Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1
    Madeleine Heroux
    Department of Biochemistry and Groupe de Recherche Universitaire sur le Médicament, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 282:31610-20. 2007
    ....
  39. ncbi Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma
    Lars M Ittner
    Laboratory for Orthopedic Research, Orthopedic University Hospital Balgrist, University of Zurich, Ch 8008 Zurich, Switzerland
    Clin Sci (Lond) 114:49-58. 2008
    ..The CLR transgenic mice used in the present study provide a model for acute angle-closure glaucoma...
  40. ncbi Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins
    S Hilairet
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 276:29575-81. 2001
    ..Overall, the data indicate that direct protein-protein interactions dictate the pharmacological properties of the CRLR-RAMP complexes...
  41. ncbi Tissue-specific and ubiquitous promoters direct the expression of alternatively spliced transcripts from the calcitonin receptor gene
    O Anusaksathien
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Biol Chem 276:22663-74. 2001
    ..These transfection data confirm the osteoclast specificity of promoter P3 and provide the first evidence that the CTR gene is regulated in a tissue-specific manner by alternative promoter utilization...
  42. ncbi Calcitonin receptors of human osteoclastoma
    G C Nicholson
    University of Melbourne, Department of Medicine, Repatriation General Hospital, Heidelberg, Victoria, Australia
    Horm Metab Res 19:585-9. 1987
    ..The multinucleate giant cells (osteoclasts) of human osteoclastomas possess large number of CT receptors which exhibit the same binding kinetics and apparent Mr as those of other CT target cells...
  43. ncbi Role of the N-terminal domain of the calcitonin receptor-like receptor in ligand binding
    Madhu Chauhan
    Departments of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA
    Biochemistry 44:782-9. 2005
    ..25 and 0.29 muM, respectively). Taken together, our data provide evidence that Nt-CRLR is structured and further that a significant part of the binding affinity comes from binding to the Nt-domain...
  44. ncbi Calcitonin receptors, bone sialoprotein and osteopontin are expressed in primary breast cancers
    M T Gillespie
    St Vincent s Institute of Medical Research and The University of Melbourne, Department of Medicine, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Int J Cancer 73:812-5. 1997
    ..Expression of CTR, BSP and OPN may prove to be a useful marker for breast cancers, and their role in the homing of breast cancer cells to bone remains to be investigated...
  45. ncbi Iodine-123 salmon calcitonin, an imaging agent for calcitonin receptors: synthesis, biodistribution, metabolism and dosimetry in humans
    P J Blower
    Department of Nuclear Medicine, Kent and Canterbury Hospital, Canterbury, UK
    Eur J Nucl Med 25:101-8. 1998
    ..In summary, [123I]diiodotyrosyl22-SCT binds to calcitonin receptors and can image sites of Paget's disease but its imaging potential is not optimal because of rapid breakdown ..
  46. ncbi Adrenomedullin enhances invasion by trophoblast cell lines
    Xiaoquan Zhang
    Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, 77555, USA
    Biol Reprod 73:619-26. 2005
    ..Our data support the notion that ADM may be involved in the human implantation process via regulating trophoblast proliferation and differentiation...
  47. ncbi Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling
    S Kamitani
    Shionogi Research Laboratories, Shionogi and Co Ltd, 2 5 1 Mishima, Settsu shi, 566 0022, Osaka, Japan
    Biochim Biophys Acta 1539:131-9. 2001
    ..It thus appears that glycosylation of Asn123 is required for CRLR to assume the appropriate conformation on the cell surface through its interaction with RAMPs...
  48. ncbi Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus
    L L Nikitenko
    Nuffield Department of Obstetrics and Gynaecology, Imperial Cancer Research Fund, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Mol Hum Reprod 7:655-64. 2001
    ....
  49. ncbi Effects of endothelin on adrenomedullin secretion and expression of adrenomedullin receptors in rat cardiomyocytes
    K Mishima
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 287:264-9. 2001
    ..These findings suggest that ET-1 not only stimulates AM secretion, but also modulates intracellular cAMP responses to AM probably by altering the expressions of CRLR and RAMPs in rat cardiomyocytes...
  50. ncbi Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes
    Debbie L Hay
    School of Biological Sciences, University of Auckland, New Zealand
    Mol Pharmacol 67:1655-65. 2005
    ....
  51. ncbi Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat
    K R Oliver
    Merck Research Laboratories, Neuroscience Research Centre, Harlow, Essex CM20 QR, UK
    Eur J Neurosci 14:618-28. 2001
    ..Furthermore, these localization data suggest that the RAMP family may associate and modify the behaviour of other, as yet unidentified neurotransmitter receptors...
  52. ncbi Evidence for decreased calcitonin gene-related peptide (CGRP) receptors and compromised responsiveness to CGRP of fetoplacental vessels in preeclamptic pregnancies
    Yuan Lin Dong
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Medical Research Building, 11 138, Galveston, Texas 77555 1062, USA
    J Clin Endocrinol Metab 90:2336-43. 2005
    ..We concluded that CGRP may contribute to the low fetoplacental vascular resistance in normal pregnancies; however, CGRP-dependent vascular relaxation appears to be compromised in preeclamptic pregnancies...
  53. ncbi Expression of adrenomedullin and its receptors in the human adrenal cortex and aldosteronomas
    G Albertin
    Department of Human Anatomy and Physiology Section of Anatomy, School of Medicine, University of Padua, Via Gabelli 65, I 35121 Padua, Italy
    Int J Mol Med 8:423-6. 2001
    ..In conclusion, our investigation provides the first evidence that human adrenal cortex and aldosteronomas express the ADM system, that may play a role in the paracrine or autocrine control of their functions...
  54. ncbi [Adrenomedullin receptor and its signal transduction]
    Nozomi Fukai
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
    Nihon Rinsho 62:189-92. 2004
  55. ncbi Amylin receptors: molecular composition and pharmacology
    D L Hay
    School of Biological Sciences, University of Auckland, Symonds Street, Auckland, New Zealand
    Biochem Soc Trans 32:865-7. 2004
    ..The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed...
  56. ncbi Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin
    A C Conner
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochem Soc Trans 32:843-6. 2004
    ..BIBN4096BS, a CGRP antagonist, targets RAMP1 and this gives the compound very high selectivity for the human CGRP(1) receptor...
  57. ncbi Estrogen and phytoestrogen regulate the mRNA expression of adrenomedullin and adrenomedullin receptor components in the rat uterus
    Kazuhiro Ikeda
    Department of Environmental Medicine, Center for Community Medicine, Jichi Medical School, Yakushiji 3311 1, Minamikawachi Machi, Kawachi gun, Tochigi 329 0498, Japan
    Mol Cell Endocrinol 223:27-34. 2004
    ..In addition, treatment with ADM increased uterine weight and edema similar to that observed after Cou treatment. Our findings indicated that the phytoestrogen caused the abnormal induction of vasoactive factors in the uterus...
  58. ncbi Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells
    I Makino
    Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, 814 0180, Japan
    Biochem Biophys Res Commun 288:515-20. 2001
    ..The results suggest that the increase in functional AM receptor during phenotypic change may in part contribute to the development of vascular lesions, such as in atherosclerosis...
  59. ncbi The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors
    Debbie L Hay
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
    J Mol Neurosci 22:105-13. 2004
    ..The CGRP-selectivity of RAMP1 and RAMP3 may be conferred by a putative disulfide bond from the N-terminus to the middle of the extracellular domain of these molecules. This is not present in RAMP2...
  60. ncbi Identification, structural determination, and biological activity of bovine and canine calcitonin receptor-stimulating peptides
    Takeshi Katafuchi
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 313:74-9. 2004
    ....
  61. ncbi [Expression of adrenomedullin and its receptor mRNA in the tissues of normal adrenal medulla and pheochromocytoma]
    Dong mei Liu
    Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:452-6. 2005
    ..To investigate the expression of human adrenomedullin (ADM) and its receptor-receptor activity modifying protein 2/calcitonin receptor-like receptor (RAMP2/CRLR) mRNA in the tissues of normal adrenal medulla and pheochromocytoma...
  62. ncbi [Discovery and significance of calcitonin]
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
    Nihon Rinsho 63:165-8. 2005
  63. ncbi Calcitonin gene-related peptide receptor activation by receptor activity-modifying protein-1 gene transfer to vascular smooth muscle cells
    Zhongming Zhang
    Department of Physiology and Biophysics, University of Iowa, Iowa City, 52242, USA
    Endocrinology 147:1932-40. 2006
    ..The mechanisms underlying these effects involved cAMP-dependent pathways. We propose that RAMP1 gene transfer may be an effective strategy for increasing the effectiveness of CGRP-induced decrease in restenosis after aortic angioplasty...
  64. doi Pharmacological and kinetic characterization of adrenomedullin 1 and calcitonin gene-related peptide 1 receptor reporter cell lines
    Frank Wunder
    Bayer HealthCare AG, Lead Discovery Wuppertal, Pharma Research Center, Aprather Weg 18a, D 42096 Wuppertal, Germany
    Mol Pharmacol 73:1235-43. 2008
    ..In addition, luminescence signal kinetics after activation of G(s)- and G(q)-coupled receptors were found to be markedly different...
  65. ncbi The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors
    Madhara Udawela
    Howard Florey Institute, The University of Melbourne, Parkville, 3010, Victoria, Australia
    Regul Pept 145:65-71. 2008
    Receptor activity modifying proteins (RAMPs) interact with calcitonin receptors to produce novel amylin receptor phenotypes...
  66. ncbi The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells
    S Kamitani
    Shionogi Institute for Medical Science, Shionogi and Co Ltd, Osaka, Japan
    FEBS Lett 448:111-4. 1999
    ..Thus, the receptor activity-modifying protein 2/calcitonin receptor-like receptor complex apparently serves as a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells...
  67. ncbi Effects of calcitonin on the function of human osteoclast-like cells formed from CD14-positive monocytes
    Y Yamamoto
    Department of Periodontology, School of Dentistry, Aichi Gakuin University, Suemori, Chikusa ku, Nagoya, Aichi, Japan
    Cell Mol Biol (Noisy-le-grand) 52:25-31. 2006
    ..These results suggest that both PKA- and PKC-mediated signals are involved in calcitonin-induced inhibition of human OCL function...
  68. ncbi Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion
    Zhongming Zhang
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 27:2693-703. 2007
    ..These results demonstrate that RAMP1 is functionally rate limiting for CGRP receptor activity in the trigeminal ganglion, which raises the possibility that elevated RAMP1 might sensitize some individuals to CGRP actions in migraine...
  69. ncbi A critical role for the short intracellular C terminus in receptor activity-modifying protein function
    Madhara Udawela
    Drug Discovery Biology Laboratory, Department of Pharmacology, Bldg 13E, Monash University, Clayton, 3800 Victoria, Australia
    Mol Pharmacol 70:1750-60. 2006
    ..Thus, this study reveals important functionality of the RAMP C-terminal domain and identifies key differences in the role of the RAMP C terminus for CTR versus CLR-based receptors...
  70. ncbi Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells
    A Aldecoa
    Research Laboratory for Calcium Metabolism, Departments of Orthopaedic Surgery and Medicine, University of Zurich, Klinik Balgrist, Forchstrasse 340, 8008, Zurich, Switzerland
    FEBS Lett 471:156-60. 2000
    ..In conclusion, [(125)I]CGRP/rCRLR/RAMP1 and [(125)I]ADM/rCRLR/RAMP2 complexes have been recognized in Drosophila S2 cells...
  71. ncbi Expression of calcitonin receptor in rat mammary gland during lactation
    Aiko Ishii
    Department of Pathology, Wakayama Medical University, Wakayama, Japan
    Endocr J 53:317-24. 2006
    ..These results suggest that up-regulation of CTR during lactation may contribute to inhibition of mammary epithelial cell proliferation...
  72. ncbi Dexamethasone increases RAMP1 and CRLR mRNA expressions in human vascular smooth muscle cells
    S Frayon
    Hopital Lariboisiere, Unité 349 de l INSERM, 2 rue Ambroise Pare, Paris Cedex 10, 75475, France
    Biochem Biophys Res Commun 270:1063-7. 2000
    ..Thus, we suggest that, in vivo, glucocorticoids are involved in the expression of CGRP receptors by human coronary VSMC...
  73. ncbi A critical role for adrenomedullin-calcitonin receptor-like receptor in regulating rheumatoid fibroblast-like synoviocyte apoptosis
    Benjamin Uzan
    Institut National de la Sante et de la Recherche Medicale, Unité 606, IFR 139, Centre Viggo Petersen, Hopital Lariboisiere, 2 rue Ambroise Pare, F 75010 Paris, France
    J Immunol 176:5548-58. 2006
    ..Our data suggest that ADM may prevent or reduce RA-FLS apoptosis, via up-regulation of its functional receptor CRLR/RAMP-2. Regulation of ADM secretion and/or CRLR/RAMP-2 activation may constitute new treatment strategies for RA...
  74. ncbi Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function
    K Husmann
    Research Laboratory for Calcium Metabolism, Departments of Orthopaedic Surgery and Medicine, Zurich, Switzerland
    Mol Cell Endocrinol 162:35-43. 2000
    ..In conclusion, mouse RAMP1, -2 and -3 exhibit high amino acid sequence homology to the corresponding human RAMPs. Co-expression of rCRLR with mRAMP1, -2 or -3 in COS-7 cells revealed distinct CGRP-, ADM- or ADM/CGRP receptors...
  75. ncbi Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors
    Madhara Udawela
    Department of Pharmacology, Building 13E, Monash University, Clayton, 3800 Victoria, Australia
    Mol Pharmacol 69:1984-9. 2006
    b>Calcitonin receptors (CTRs) dimerize with receptor activity-modifying proteins (RAMPs) to generate high-affinity amylin (AMY) receptors; however, the relative contribution of individual RAMP domains to the formation of AMY receptors is ..
  76. ncbi Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms
    Leonid L Nikitenko
    Nuffield Department of Obstetrics and Gynaecology, The University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    J Cell Sci 119:910-22. 2006
    ..These novel findings regarding regulation of EndoCL function in endothelial cells are likely to be of importance in conditions where AM or CGRP levels are elevated, such as cardiovascular disease, diabetes and inflammation...
  77. ncbi Characterisation of CGRP receptors in human and porcine isolated coronary arteries: evidence for CGRP receptor heterogeneity
    Saurabh Gupta
    Department of Pharmacology, University Medical Center Rotterdam, The Netherlands
    Eur J Pharmacol 530:107-16. 2006
    ....
  78. ncbi Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2
    C W Tam
    Cardiovascular Division, King s College London, United Kingdom
    Circ Res 98:262-70. 2006
    ..Thus RAMP2 plays a key role in the sensitivity and potency of AM-induced hypotensive responses via the AM1 receptor, providing evidence that this receptor is a selective target for novel therapeutic approaches...
  79. ncbi Female sex steroid hormones and pregnancy regulate receptors for calcitonin gene-related peptide in rat mesenteric arteries, but not in aorta
    C Yallampalli
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 1062, USA
    Biol Reprod 70:1055-62. 2004
    ....
  80. ncbi Functional expression of heteromeric calcitonin gene-related peptide and adrenomedullin receptors in yeast
    Juan J Miret
    OSI Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591 6705, USA
    J Biol Chem 277:6881-7. 2002
    ..The first functional reconstitution of a heteromeric seven transmembrane receptor in yeast suggests this organism as a useful research tool to study the molecular nature of other heteromeric receptors...
  81. ncbi Saturation of adrenomedullin receptors plays an important role in reducing pulmonary clearance of adrenomedullin during the late stage of sepsis
    David A Ornan
    Center for Surgical Research and Department of Surgery, The University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall, Room G094P, 35294, USA
    Biochim Biophys Acta 1586:299-306. 2002
    ..The lack of upregulation of RAMP-3 during late sepsis could also contribute to the decreased clearance observed during this phase...
  82. ncbi Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction
    B R Rorabaugh
    Department of Pharmacology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Pharmacol Exp Ther 299:1086-94. 2001
    ..Thus halpha-CGRP(8-37) antagonizes CGRP-induced relaxation of porcine coronary arteries with low affinity at the CGRP(1) receptor. Taken together, these data do not support the existence of the CGRP(2) receptor...
  83. ncbi Adrenomedullin stimulates proliferation and inhibits apoptosis of immature rat thymocytes cultured in vitro
    Anna S Belloni
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I 35121, Padua, Italy
    Peptides 24:295-300. 2003
    ..Taken together, these findings could suggest that AM may play a role in the development of immunity...
  84. ncbi Altered gene expression of adrenomedullin and its receptor system and molecular forms of tissue adrenomedullin in left ventricular hypertrophy induced by malignant hypertension
    Kazuyoshi Tadokoro
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Regul Pept 112:71-8. 2003
    ..Considering that AM serves as a local antihypertrophic autocrine and/or paracrine factor, the induction of AM system observed here may modulate the pathophysiology of LV hypertrophy in certain forms of malignant hypertension...
  85. ncbi Specificity of porcine calcitonin receptor and calcitonin receptor-like receptor in the presence of receptor-activity-modifying proteins
    Katsuro Kikumoto
    National Cardiovascular Center Research Institute, Suita, Japan
    Hypertens Res 26:S15-23. 2003
    ..In contrast to previous findings, porcine CTR and RAMP did not appear to form an AMY receptor having sufficient affinity and specificity for the physiological interaction...
  86. ncbi Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist
    Philip Hasbak
    Department of Clinical Experimental Research, University Hospital of Copenhagen, Glostrup, Denmark
    J Pharmacol Exp Ther 304:326-33. 2003
    ..alphaCGRP, AM, and amylin mediated vasorelaxation via the CGRP1 receptor. Compound 1 acted as a nonpeptide antagonist at the CGRP1 receptor and could thus become a tool for the study of CGRP-mediated functional responses in human tissue...
  87. ncbi The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction
    M A Prado
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33101, USA
    Peptides 22:1773-81. 2001
    ....
  88. ncbi Coexpression of calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3 mediates the antimigratory effect of adrenomedullin
    Nozomi Fukai
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Endocrinology 144:447-53. 2003
    ..Thus, coexpression of CRLR and RAMP2 or RAMP3 mediates the inhibitory effect of adrenomedullin on cell migration, independent of cAMP-dependent signaling pathways...
  89. ncbi Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells
    Stefanie Hagner
    Institute of Physiology, Philipps University, Marburg, Germany
    Digestion 66:197-203. 2002
    ..We aimed to determine whether gut immune cells are targets for calcitonin gene-related peptide (CGRP), which has potent immune regulatory properties...
  90. ncbi Production of cAMP by adrenomedullin in human oligodendroglial cell line KG1C: comparison with calcitonin gene-related peptide and amylin
    Y Uezono
    Department of Pharmacology, Miyazaki Medical College, 5200 Kihara, 889 1692, Kiyotake, Japan
    Brain Res Mol Brain Res 97:59-69. 2001
    ..receptor-like receptor (CRLR) and receptor-activity-modifying proteins (RAMPs) 1, 2 and 3 but not for calcitonin receptors were detected in the cells, while mRNAs for CRLR, calcitonin receptors and all RAMPs were detected in the ..
  91. ncbi Adrenomedullin and its receptor complexes in remnant kidneys of rats with renal mass ablation: decreased expression of calcitonin receptor-like receptor and receptor-activity modifying protein-3
    K Totsune
    Second Department of Internal Medicine, Tohoku University School of Medicine, 980 8574, Sendai, Miyagi, Japan
    Peptides 22:1933-7. 2001
    ..The present study showed that expression of mRNAs encoding AM, RAMP2, RAMP3 and CRLR were differentially regulated in remnant kidneys of rats with renal mass ablation...
  92. ncbi Novel regulation of adrenomedullin receptor by PDGF: role of receptor activity modifying protein-3
    Wojciech Nowak
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Cell Physiol 282:C1322-31. 2002
    ..Taken together, these data identify PDGF-dependent regulation of RAMP-3 expression as a possible mechanism for modulating the responsiveness of the mesangial cell to AM...
  93. ncbi Sequencing of a calcitonin receptor-like receptor in salmon Oncorhynchus gorbuscha. Functional studies using the human receptor activity-modifying proteins
    Elisabeth Pidoux
    U 349 Institut National de la Santé et de la Recherche Médicale, 6 rue Guy Patin, Centre Viggo Petersen, 75475 Paris Cedex 10, France
    Gene 298:203-10. 2002
    ..The availability of this receptor must allow to further study their structural basis. This identification of a non-mammalian CL receptor, and characterization of its function, give insight in the evolution of the CL receptor molecule...
  94. ncbi Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure
    Carine Cueille
    INSERM U349, Hopital Lariboisiere, Centre Viggo Petersen, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Biochem Biophys Res Commun 294:340-6. 2002
    ..These findings support a functional role for CGRP and ADM receptors to compensate the chronic heart failure in rats...
  95. pmc CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS
    D L Hay
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Br J Pharmacol 140:477-86. 2003
    ..On the mixed species receptor, CGRP8-37 showed the opposite selectivity. Thus, depending on the species, it is possible to discriminate pharmacologically between CL/RAMP2 and CL/RAMP3 AM receptors...
  96. ncbi Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature
    Kevin R Oliver
    The Neuroscience Research Center, Merck, Sharp and Dohme Research Laboratories, Terling s Park, Harlow, Essex CM20 2QR, United Kingdom
    J Cereb Blood Flow Metab 22:620-9. 2002
    ....
  97. ncbi Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins
    Kenji Kuwasako
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 301:460-4. 2003
    ..Co-expression of CTR(I1-) with RAMP thus appears to produce functional CT-(8-32)-sensitive AM receptors...
  98. ncbi The calcitonin receptor-like receptor/receptor activity-modifying protein 1 heterodimer can function as a calcitonin gene-related peptide-(8-37)-sensitive adrenomedullin receptor
    Yasuko Nagoshi
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Eur J Pharmacol 450:237-43. 2002
    ..Thus, CRL receptor/RAMP1 likely functions as an adrenomedullin receptor as well as a CGRP receptor, which may explain why many of the actions of adrenomedullin are potently antagonized by alpha-CGRP-(8-37)...
  99. ncbi Angiotensin II modulates gene expression of adrenomedullin receptor components in rat cardiomyocytes
    Kazuya Mishima
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
    Life Sci 73:1629-35. 2003
    ..Thus, Ang II modulates gene expression of the AM receptor components via AT1 receptor, suggesting alteration of AM actions by Ang II in cultured rat cardiomyocytes...
  100. ncbi Expression of calcitonin gene-related peptide receptor components, calcitonin receptor-like receptor and receptor activity modifying protein 1, in the rat placenta during pregnancy and their cellular localization
    Y L Dong
    Department of Obstetrics and Gynecology, 301 University Blvd, Medical Research Building, Rm 11 138, The University of Texas Medical Branch, Galveston, TX 77555 1062, USA
    Mol Hum Reprod 9:481-90. 2003
    ..Elevated placental CRLR and RAMP(1) may be involved in CGRP-related increases in blood flow and therefore fetal growth and decreases at term labour may help minimize the blood loss...
  101. ncbi Development of a novel mouse osteoclast culture system including cells of mandibular body and erupting teeth
    N Suda
    Department of Maxillofacial Reconstruction and Function, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8549 Tokyo, Japan
    Bone 33:38-45. 2003
    ....

Research Grants70

  1. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2010
    ..Prominent examples include serotonin, histamine, adrenergic, muscarinic and calcitonin receptors which are targets of current and potentially new drugs...
  2. Adrenomedullin Signaling at the Maternal-Fetal Interface
    Kathleen Caron; Fiscal Year: 2009
    ....
  3. Adrenomedullin Signaling at the Maternal-Fetal Interface
    Kathleen M Caron; Fiscal Year: 2010
    ....
  4. CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERS
    Philip Osdoby; Fiscal Year: 2002
    ....
  5. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
    ..Together, the results of these experiments will provide new insights into peptide signaling, generate novel information about mechanisms of intestinal inflammation, and suggest new strategies for therapy. ..
  6. CALCITONIN RECEPTOR GENE EXPRESSION
    Steven Goldring; Fiscal Year: 2002
    ..g. kidney). This will define the structural basis of CTR gene regulation and permit identification of potentially unique factors that regulate the CTR. ..
  7. Role of RAMPs in Intermedin Signaling
    Sheau Yu Hsu; Fiscal Year: 2009
    ....
  8. Role of RAMPs in Intermedin Signaling
    Sheau Yu Teddy Hsu; Fiscal Year: 2010
    ....
  9. Adrenomedullin Signaling in Vascular Development
    Kathleen M Caron; Fiscal Year: 2010
    ....
  10. Characterization of Neuroendocrine CGRP Receptors
    Ian Dickerson; Fiscal Year: 2006
    ..abstract_text> ..
  11. REGULATION OF THE MURINE CALCITONIN RECEPTOR GENE
    DEBORAH GALSON; Fiscal Year: 2001
    ..In addition, they will develop ES cell differentiation techniques to generate osteoclasts from E cells for studying the regulation of mCTR gene expression during osteoclast differentiation and development. ..
  12. ANIMAL MODELS FOR STUDYING THE GENETICS OF HYPERTENSION
    Oliver Smithies; Fiscal Year: 2006
    ..abstract_text> ..
  13. Chemical Synthesis of Kendomycin and Garsubellin A
    Erik Sorensen; Fiscal Year: 2009
    ..Thus, the chemistry we seek to develop through this grant application can be extended in many ways to bring significant advances in the chemical synthesis of bioactive compounds. ..
  14. Chemical Synthesis of Kendomycin and Garsubellin A
    Chulbom Lee; Fiscal Year: 2006
    ..Thus, the chemistry we seek to develop through this grant application can be extended in many ways to bring significant advances in the chemical synthesis of bioactive compounds. ..
  15. Chemical Synthesis of Kendomycin and Garsubellin A
    Erik Sorensen; Fiscal Year: 2007
    ..Thus, the chemistry we seek to develop through this grant application can be extended in many ways to bring significant advances in the chemical synthesis of bioactive compounds. ..
  16. RAMP Involvement in PTH Regulation of Bone Metabolism
    JEANNE NERVINA; Fiscal Year: 2006
    ..These studies will help us understand the mechanisms of PTH-induced RAMP1 and RAMP3 gene expression and they will unveil the impact of these genes on osteoblast function. ..
  17. Calcitonin in Prostate Growth and Neplasia
    Girish Shah; Fiscal Year: 2009
    ..The goal of this application is to elucidate early molecular events associated with CTR-stimulated TJ disassembly that lead to increased tumor growth/metastasis. ..
  18. Adrenomedullin and Human Trophoblast Invasion
    Yuan Lin Dong; Fiscal Year: 2006
    ..Knowledge gained from these studies may assist in designing appropriate therapeutic strategies to prevent preeclampsia in the human. ..