Genomes and Genes
Summary: Cell surface receptors that bind prostaglandins with high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin receptor subtypes have been tentatively named according to their relative affinities for the endogenous prostaglandins. They include those which prefer prostaglandin D2 (DP receptors), prostaglandin E2 (EP1, EP2, and EP3 receptors), prostaglandin F2-alpha (FP receptors), and prostacyclin (IP receptors).
Publications260 found, 100 shown here
- Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretionZvi Naor
Medical Research Council MRC, Huamn Reproduction Sciences, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
Mol Endocrinol 21:524-37. 2007....
- Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptorYingying Chen
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Immunol 179:2766-73. 2007..Together, these data uncover a novel mechanism by which PGD(2) functions through DP to suppress type 1 and cytolytic functions of human NK cells, thus contributing to the promotion of a type 2 immune response...
- Prostanoid receptors: structures, properties, and functionsS Narumiya
Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
Physiol Rev 79:1193-226. 1999..In this article, we summarize these findings and attempt to give an overview of the current status of research on the prostanoid receptors...
- Prostanoid receptors: subtypes and signalingR M Breyer
Division of Nephrology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
Annu Rev Pharmacol Toxicol 41:661-90. 2001..The C-terminal variants modulate signal transduction, phosphorylation, and desensitization of these receptors, as well as altering agonist-independent constitutive activity...
- Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2H Hirai
R and D Center, BML, Saitama 350 1101, Japan
J Exp Med 193:255-61. 2001..In addition, CRTH2, but not DP, mediates PGD2-dependent cell migration of blood eosinophils and basophils. Thus, PGD2 is likely involved in multiple aspects of allergic inflammation through its dual receptor systems, DP and CRTH2...
- T-cell trafficking in asthma: lipid mediators grease the wayAndrew D Luster
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Building 149 8301, 13th Street, Charlestown, Massachusetts 02129, USA
Nat Rev Immunol 4:711-24. 2004..However, as we discuss here, the recent molecular identification of leukotriene and prostaglandin receptors, as well as the generation of mice that are genetically deficient in them, has revealed that two of these ..
- Immunohistochemical demonstration of cyclooxygenase-2 (COX-2) and prostaglandin receptors EP2 and FP expression in the bovine intercaruncular uterine wall around termD Wehbrink
Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
Anim Reprod Sci 106:241-54. 2008..EP2 remains rather unchanged during the peripartal period. COX-2 and FP thus contribute via changes in amount and distribution to mechanisms associated with parturition...
- Emerging roles of DP and CRTH2 in allergic inflammationEvi Kostenis
Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6, D 53155 Bonn, Germany
Trends Mol Med 12:148-58. 2006..Here, we examine the roles of DP and CRTH2 in the orchestration of complex inflammatory processes, and discuss their importance as emerging targets for the treatment of asthma and inflammatory diseases...
- Molecular cloning and characterization of the human prostanoid DP receptorY Boie
Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
J Biol Chem 270:18910-6. 1995..In summary, we have cloned and expressed a functional cDNA for the hDP receptor...
- Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DPF G Gervais
Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
J Allergy Clin Immunol 108:982-8. 2001..PGD(2) is the major prostanoid released by mast cells during an allergic response. Its role in the allergic response, however, remains unclear...
- Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cellsLuzheng Xue
Oxagen Limited, Abingdon, Oxon, United Kingdom
J Immunol 175:6531-6. 2005....
- Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulationAaron N Hata
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
Pharmacol Ther 103:147-66. 2004..The precise roles prostaglandin receptors play in physiologic and pathologic settings are determined by multiple factors including cellular context,..
- Prostaglandin D2 as a mediator of allergic asthmaT Matsuoka
Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
Science 287:2013-7. 2000..Moreover, DP-/- mice showed only marginal infiltration of eosinophils and failed to develop airway hyperreactivity. Thus, PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses...
- CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)K Nagata
Research and Development Center, BioMedical Laboratories, Inc, 1361 1 Matoba, Kawagoe, Saitama, Japan
FEBS Lett 459:195-9. 1999..These findings implied the involvement of CRTH2 in mast cell-mediated immune responses such as allergic reactions...
- Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseasesRoy Pettipher
Oxagen Limited, 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, UK
Nat Rev Drug Discov 6:313-25. 2007..We also discuss recent progress in the discovery and development of selective antagonists of these receptors...
- Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptorTakahiro Satoh
Department of Dermatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
J Immunol 177:2621-9. 2006..These findings indicate that the PGD(2)-CRTH2 system plays a significant role in chronic allergic skin inflammation. CRTH2 may represent a novel therapeutic target for treatment of human allergic disorders, including atopic dermatitis...
- International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypesR A Coleman
Glaxo Research and Development, Ltd, Ware, Hertfordshire, England
Pharmacol Rev 46:205-29. 1994
- 9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2Hilary Sandig
Leukocyte Biology Section, NHLI Division, Imperial College Faculty of Medicine, South Kensington, London SW7 2AZ, UK
FEBS Lett 580:373-9. 2006....
- Selective expression of a novel surface molecule by human Th2 cells in vivoK Nagata
R and D Center, BioMedical Laboratories, Kawagoe, Saitama, Japan
J Immunol 162:1278-86. 1999..Together, these results indicate that CRTH2 is selectively expressed in vivo in an activated state of Th2 cells including allergen-responsive Th2 cells, suggesting its pivotal roles in ongoing Th2-type immune reactions...
- Cyclooxygenase enzymes and prostaglandins in reproductive tract physiology and pathologyK J Sales
MRC Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
Prostaglandins Other Lipid Mediat 71:97-117. 2003....
- Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cellsPhilippe Gosset
Institut National de la Sante et de la Recherche Medicale, Unité 416 and Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
J Immunol 170:4943-52. 2003..Finally, in a model of Th CD45RA(+) differentiation induced by allergen- and superantigen-pulsed DC, PGD(2) impacts on the orientation of the immune response by favoring a Th2 response...
- cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medullaT Namba
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
J Biol Chem 269:9986-92. 1994..Northern blot analysis revealed that the mRNA is expressed most abundantly in thymus, followed by spleen, heart, and lung. In situ hybridization of thymus showed that it is expressed exclusively in medulla and not in cortex...
- Altered pain perception and inflammatory response in mice lacking prostacyclin receptorT Murata
Department of Pharmacology, Faculty of Medicine, Kyoto University, Sakyo, Japan
Nature 388:678-82. 1997..Our results establish that prostacyclin is an antithrombotic agent in vivo and provide evidence for its role as a mediator of inflammation and pain...
- Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathwaysChristelle Faveeuw
INSERM U547, Institut Pasteur de Lille, Lille, France
Eur J Immunol 33:889-98. 2003..Together these data suggest that PGD(2), by interacting with DP1 and by binding to other target cellular proteins, may regulate immune responses by affecting IL-12 production in DC...
- A novel pathway of prostacyclin signaling-hanging out with nuclear receptorsHyunjung Lim
Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Endocrinology 143:3207-10. 2002..This review attempts to cover recent developments in nuclear actions of PGI(2) in diverse biological functions...
- The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytesKinya Nagata
R and D Centre, Bio Medical Laboratories, Inc, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
Prostaglandins Leukot Essent Fatty Acids 69:169-77. 2003..The data suggest that the PGD(2)/CRTH2 system play important roles in allergic inflammation through its stimulatory effects on Th2 cells, eosinophils, and basophils...
- Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway ratsWagdi Almishri
Meakins Christie Laboratories, McGill University, 3626 St Urbain St, Montreal, QC, Canada H2X 2P2
J Pharmacol Exp Ther 313:64-9. 2005..The potent in vitro DP2 receptor agonist 15R-methyl-PGD2 is also very active in vivo and should be a useful tool in examining the role of this receptor...
- Expression and localization of the contractile prostaglandin F receptor in pregnant rat myometrium in late gestation, labor, and postpartumH Y Al-Matubsi
Department of Obstetrics and Gynecology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267-0526, USA
Biol Reprod 65:1029-37. 2001..Our study suggests an increase in FP-receptor protein in myometrium with advancing gestation and a marked elevation at term. This supports a role for uterine FP receptors in mediation of uterine contractility at term...
- Characterization of the prostaglandin receptors in human osteoblasts in cultureP Sarrazin
Department of Medicine, Faculty of Medicine, , Sherbrooke, Canada
Prostaglandins Leukot Essent Fatty Acids 64:203-10. 2001..All receptors found by RT-PCR were coupled to second messengers except for the DP subtype. These results clearly show the presence of functional EP(4), IP, FP and TP receptors in human osteoblasts in culture...
- Temporal and tissue-specific expression of prostaglandin receptors EP2, EP3, EP4, FP, and cyclooxygenases 1 and 2 in uterus and fetal membranes during bovine pregnancyJ A Arosh
Unité D Ontogénie and Reproduction, Centre de Recherche du CHUL, Ste Foy, Quebec, Canada G1V 4G2
Endocrinology 145:407-17. 2004..Temporal and tissue-specific expression of PGE2 and PGF2alpha receptors and COX-1 and -2 at the maternal-fetal interface suggests a selective and distinctive role for PGE2 and PGF2alpha in uterine activities during pregnancy in bovine...
- Prostaglandin receptors EP2 and IP are detectable in atherosclerotic arteries and plaquesA Muto
Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT, USA
Int Angiol 29:43-8. 2010..In this study, we analyzed the distribution of these PG receptors in patients with severe ASO to determine the potential application of stimulation of these receptors as targets for pharmacological treatment...
- Prostaglandin receptors and role of G protein-activated pathways on corpora lutea of pseudopregnant rabbit in vitroC Boiti
Dipartimento di Patologia, Diagnostica e Clinica Veterinaria, Universita di Perugia, Via S Costanzo 4, I 016126 Perugia, Italy
J Endocrinol 168:141-51. 2001..The time-dependent selective resistance to PGF(2alpha) and PGE(2) by rabbit CL is mediated by factors other than a lack of luteal receptor-ligand interactions...
- The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responsesR Pettipher
Oxagen Ltd, 91 Milton Park, Abingdon, Oxon, UK
Br J Pharmacol 153:S191-9. 2008..The role played by CRTH2 in promoting the production of Th2 cytokines and IgE make antagonism of this receptor a particularly attractive approach to the treatment of chronic allergic disease...
- Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout miceJonathan G Crowston
Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, California 92093 0946, USA
Invest Ophthalmol Vis Sci 46:4571-7. 2005..To determine the effect of bimatoprost on intraocular pressure in the prostaglandin FP receptor knockout mouse...
- Cloning and expression of a cDNA for the human prostanoid FP receptorM Abramovitz
Department of Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
J Biol Chem 269:2632-6. 1994..In summary, we have cloned the human prostanoid FP receptor which is functionally coupled to the Ca2+ signalling pathway...
- Prostaglandin receptors mediate effects of substances released from ischaemic rat hearts on non-ischaemic cardiomyocytesK Birkenmeier
Klinik für Innere Medizin B, Ernst Moritz Amdt Universität Greifswald, Greifswald, Germany
Eur J Clin Invest 38:902-9. 2008..The present study analyses the mechanisms by which these substances mediate their effect downstream of cyclooxygenase-2...
- Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonistTrond Ulven
7TM Pharma A S, Fremtidsvej 3, DK 2970 Hørsholm, Denmark
J Med Chem 48:897-900. 2005..This is the first selective CRTH2 antagonist described to date, and should prove highly valuable in further elucidating the biological significance of CRTH2...
- New insights into the intracellular mechanisms by which PGI2 analogues elicit vascular relaxation: cyclic AMP-independent, Gs-protein mediated-activation of MaxiK channelYoshio Tanaka
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
Curr Med Chem Cardiovasc Hematol Agents 2:257-65. 2004..Our recent work demonstrates a functional tight coupling between IPR and MaxiK channel through a cAMP-independent, G(s)-protein mediated mechanism(s) in vascular smooth muscle...
- Expression, localization and function of prostaglandin receptors in myometriumLeslie Myatt
Deparment of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, PO Box 670526, Cincinnati, OH 45267, USA
Prostaglandins Leukot Essent Fatty Acids 70:137-48. 2004..Studies to determine the role of PG receptors in this phenomenon are currently underway...
- Modulation of JB6 mouse epidermal cell transformation response by the prostaglandin F2alpha receptorThomas J Weber
Molecular Biosciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Mol Carcinog 35:163-72. 2002..Erk activity appears to be a convergence point in the EGF and FP pathways. The data raise the possibility that the FP contributes to clonal selection processes but probably plays a more important role as a response modifier...
- Dissociation of the contractile and hypertrophic effects of vasoconstrictor prostanoids in vascular smooth muscleG W Dorn
Department of Medicine Cardiology, University of Cincinnati College of Medicine, Ohio 45267
J Biol Chem 267:24897-905. 1992..We suggest that the main physiologic effect of PGF2 alpha may be as a stimulus for vascular smooth muscle cell hypertrophy, not as a contractile agonist...
- Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitisHiroshi Fujishima
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
Cornea 24:S66-S70. 2005..In the present study, both eosinophil toxic activity for corneal epithelial cells and chemotaxis induced by PGD2 in normal volunteers were investigated. Expression of CRTH2 in normal subjects was also measured...
- Prostanoid receptors: ontogeny and implications in vascular physiologyD H Wright
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G-1Y6, Canada
Am J Physiol Regul Integr Comp Physiol 281:R1343-60. 2001..This article reviews prostanoid receptors and addresses implications on the developing subject with attention to vascular physiology...
- Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptorS Lake
Pharmacia BioScience Center, Stockholm, Sweden
FEBS Lett 355:317-25. 1994..Using [3H]PGF2 alpha, binding of PGs showed the rank order of fluprostenol > PhXA70 > PGF2 alpha > or = PhXA85 > PGD2 > PGE2...
- Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular diseaseDarbie Maccubbin
Merck Research Laboratories, Rahway, NJ, USA
Am J Cardiol 104:74-81. 2009..In conclusion, improvement in flushing with ERN/LRPT versus gradually titrated N-ER supports a rapidly advanced 1-g --> 2-g dosing regimen, allowing patients to start at 1 g and quickly reach and tolerate the optimal 2 g dose of ERN...
- Update on the role of prostaglandins in allergic lung inflammation: separating friends from foes, harder than you might thinkMartin L Moore
Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Lung Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Allergy Clin Immunol 117:1036-9. 2006..This review summarizes the current literature on the role of PGs and PG receptors in allergic lung inflammation...
- Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptorYoshiki Shiraishi
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Pharmacol Exp Ther 312:954-60. 2005..These results suggest that CRTH2 plays a significant role in the eosinophil trafficking from the bloodstream into the airways in PGD(2)-related airway inflammation...
- 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophilsEva Böhm
Department of Experimental and Clinical Pharmacology, Medical University Graz, A 8010 Graz, Austria
J Biol Chem 279:7663-70. 2004..Given its production in the allergic lung, antagonism of the 11-dehydro-TXB(2)/CRTH2axis may be of therapeutic relevance...
- A positive feedback loop that regulates cyclooxygenase-2 expression and prostaglandin F2alpha synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathwayHenry N Jabbour
Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
Endocrinology 146:4657-64. 2005..Finally, we have shown that PGF2alpha could potentiate tumorigenesis in endometrial adenocarcinoma explants by inducing the expression of COX-2 mRNA...
- Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response elementKurt J Sales
MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Old Dalkeith Road, Edinburgh, United Kingdom
Mol Cell Endocrinol 285:51-61. 2008..These data indicate that PGE(2) and PGF(2alpha) biosynthesized locally within endometrial adenocarcinomas can regulate tumor cell function in an autocrine/paracrine manner via the FP receptor...
- Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in ratsMichitaka Shichijo
Research Center Kyoto, Respiratory Research, Bayer Yakuhin, Ltd, 6 5 1 3 Kunimidai, Kizu cho, Sorakugun, 619 0216 Kyoto, Japan
J Pharmacol Exp Ther 307:518-25. 2003....
- Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1Hamida Hammad
Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
J Immunol 171:3936-40. 2003....
- Cyclooxygenase enzymes and prostaglandins in pathology of the endometriumKurt J Sales
MRC Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh Academic Center, 49 Little France Crescent, Old Dalkeith Road, Edinburgh, EH16 4SB, UK
Reproduction 126:559-67. 2003....
- An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitroHiromi Sugimoto
Respiratory Diseases Research, and Medicinal Chemistry, Bayer Yakuhin, Ltd, Kyoto, Japan
J Pharmacol Exp Ther 305:347-52. 2003..Our findings suggest that clinical efficacy of ramatroban may be in part mediated through its action on this Th2-, eosinophil-, and basophil-specific chemoattractant receptor...
- Failure of parturition in mice lacking the prostaglandin F receptorY Sugimoto
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan
Science 277:681-3. 1997..These results indicate that parturition is initiated when prostaglandin F2alpha interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis...
- The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient miceTakashi Ota
Department of Ophthalmology, University of Tokyo School of Medicine, Japan
Invest Ophthalmol Vis Sci 46:4159-63. 2005..This study was designed to clarify the involvement of the prostanoid FP receptor in the intraocular pressure (IOP)-lowering effects of latanoprost, travoprost, bimatoprost, and unoprostone with the use of FP-receptor-deficient (FPKO) mice...
- Effects of laropiprant on nicotinic acid-induced flushing in patients with dyslipidemiaJohn F Paolini
Merck Research Laboratories, Rahway, NJ, USA
Am J Cardiol 101:625-30. 2008..LRPT plus ERN was well tolerated. In conclusion, the significant reduction in ERN-induced flushing provided by LRPT plus ERN supports an accelerated ERN dose-advancement paradigm to achieve rapidly a 2-g dose in dyslipidemic patients...
- Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteinsY Sugimoto
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
J Biol Chem 268:2712-8. 1993....
- The DP receptor, allergic inflammation and asthmaKenji Kabashima
Faculty of Medicine, 2nd Department of Pharmacology, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Prostaglandins Leukot Essent Fatty Acids 69:187-94. 2003..In this article, we summarize these findings and provide an overview of the current status of the DP receptor research to discuss the therapeutic potential of modulating the PGD(2)-DP pathway in allergic diseases...
- Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic miceYasushi Fujitani
Core Research for Evolutional Science and Technology, Japan Science and Technology Corp, Suita, Osaka, Japan
J Immunol 168:443-9. 2002..These results indicate that PGD(2) plays an important role in late phase allergic reactions in the pathophysiology of bronchial asthma...
- Prostaglandin (PG) F(2alpha) receptor expression and signaling in human endometrium: role of PGF(2alpha) in epithelial cell proliferationStuart A Milne
Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
J Clin Endocrinol Metab 88:1825-32. 2003....
- Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolismI Matias
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Napoli, Italy
J Pharmacol Exp Ther 309:745-57. 2004....
- UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytesAdrienne T Black
Department of Pharmacology and Toxicology, Rutgers University, USA
Toxicol Appl Pharmacol 232:14-24. 2008..Moreover, both the capacity of keratinocytes to generate prostaglandins and their ability to respond to these lipid mediators are stimulated by exposure to UVB...
- Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024)D F Woodward
Department of Biological Sciences, Allergan, Inc, 2525 Dupont Dr, Irvine, CA 92612, USA
J Pharmacol Exp Ther 305:772-85. 2003..Bimatoprost was overwhelmingly the predominant molecular species identified at all time points in ocular tissues, indicating that the intact molecule reduces intraocular pressure...
- Proteinase-activated receptor-2 stimulates prostaglandin production in keratinocytes: analysis of prostaglandin receptors on human melanocytes and effects of PGE2 and PGF2alpha on melanocyte dendricityGlynis Scott
Department of Dermatology, School of Medicine, University of Rochester, Rochester, New York, USA
J Invest Dermatol 122:1214-24. 2004....
- Myometrial activation and preterm labour: evidence supporting a role for the prostaglandin F receptor--a reviewD M Olson
The Perinatal Research Centre, The CIHR Group in Perinatal Health and Disease, Department of Obstetrics and Gynaecology, The University of Alberta, Edmonton, Canada
Placenta 24:S47-54. 2003..Finally new data showing that administration of a specific FP antagonist delays preterm birth in sheep will be presented...
- Prostanoids and pain: unraveling mechanisms and revealing therapeutic targetsTarek A Samad
Neural Plasticity Research Group, Dept of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Trends Mol Med 8:390-6. 2002....
- Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouseIsabelle Spik
Unite 547, Institut National de la Sante et de la Recherche Medicale, Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
J Immunol 174:3703-8. 2005..Taken together, these results support the hypothesis that DP2 might play a critical role in allergic diseases and underline the interest of DP2 antagonists in human therapy...
- Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathwaysKurt J Sales
Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh Academic Center, Edinburgh, United Kingdom EH16 4SB
J Clin Endocrinol Metab 89:986-93. 2004..These data suggest that PGF(2 alpha)-FP receptor promote endometrial tumorigenesis via a phospholipase C-mediated phosphorylation of the EGFR and MAPK signaling pathways...
- Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stabilityJing Long Huang
The Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
Hum Mol Genet 13:2691-7. 2004..11q is a strong candidate gene for asthma...
- Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptorsCurtis R Kelly
Molecular Pharmacology Unit, Pharmaceutical Products Research, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
J Pharmacol Exp Ther 304:238-45. 2003....
- Pivotal roles of the parasite PGD2 synthase and of the host D prostanoid receptor 1 in schistosome immune evasionMaxime Hervé
INSERM U547, Institut Pasteur de Lille, Lille, France
Eur J Immunol 33:2764-72. 2003..We also suggest that DP1 is important in the Th1/Th2 balance of the immune response and in inflammatory reactions during infection...
- Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblastsFerhana Y Ali
Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, London, UK
Am J Respir Cell Mol Biol 34:242-6. 2006..This study is the first to identify PPARbeta as a potential therapeutic target for the treatment of pulmonary hypertension, which is important because orally active PPARbeta ligands have been developed for the treatment of dyslipidemia...
- THG113: a novel selective FP antagonist that delays preterm laborKrishna G Peri
Department of Pediatrics, Research Center of Hôpital Ste Justine, Montreal, Quebec
Semin Perinatol 26:389-97. 2002..05 g), and appeared healthy. This study describes an effective and selective noncompetitive FP antagonist, THG113, which significantly delays preterm delivery; this provides the basis for future investigations for its use in tocolysis...
- Cloning of pig prostaglandin F2alphaFP receptor cDNA and expression of its mRNA in the corpora luteaU Boonyaprakob
Department of Farm Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Reproduction 125:53-64. 2003..Direct luteal targets of PGF(2alpha) appear to be primarily large steroidogenic cells in this species...
- Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2Aaron N Hata
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
Mol Pharmacol 67:640-7. 2005..Together, these results reveal structural features of arylacetic acid NSAIDs that may be exploited for the development of selective CRTH2 ligands...
- Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissuesUrsula Schlötzer-Schrehardt
Department of Ophthalmology, University of Erlangen Nurnberg, Schwabachanlage 6, D 91054 Erlangen, Germany
Invest Ophthalmol Vis Sci 43:1475-87. 2002..To determine the expression and precise cellular and subcellular localization of the EP prostanoid receptor subtypes EP(1) through EP(4) and the FP receptor in normal human ocular tissues on the protein and mRNA levels...
- Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseasesGye Young Park
Department of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois, 840 S Wood St, Chicago, IL 60612, USA
Am J Physiol Lung Cell Mol Physiol 290:L797-805. 2006..These data have suggested a number of cell-specific, pathway-specific, and receptor-specific approaches that could lead to effective therapeutic interventions for most inflammatory lung diseases...
- On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2Jesper Mosolff Mathiesen
7TM Pharma A S, Fremtidsvej 3, 2970 Hørsholm, Denmark
Mol Pharmacol 69:1441-53. 2006..A mechanistic understanding of insurmountability of CRTH2 antagonists could be fundamental for development of this novel class of anti-inflammatory drugs...
- Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humansKang Cheng
Department of Cardiovascular Diseases, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
Proc Natl Acad Sci U S A 103:6682-7. 2006..These studies suggest that DP1 receptor antagonism may be an effective means to suppress NA-induced flushing in humans...
- Prostaglandin receptors are mediators of vascular function in endometrial pathologiesHenry N Jabbour
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
Mol Cell Endocrinol 252:191-200. 2006..Here we provide an overview of some of the findings from these studies with specific emphasis on the role of cyclooxygenase enzymes, prostaglandins and their receptors in benign and neoplastic pathologies of the human endometrium...
- F-prostanoid receptor regulation of fibroblast growth factor 2 signaling in endometrial adenocarcinoma cellsKurt J Sales
Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland EH16 4TJ, United Kingdom
Endocrinology 148:3635-44. 2007....
- Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptorA Watabe
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
J Biol Chem 268:20175-8. 1993..These results suggest that this receptor belongs to EP1 subtype of PGE receptor. Northern blot analysis demonstrated that the mRNA of this receptor is expressed abundantly in kidney and in a lessor amount in lung...
- Co-expression of prostaglandin receptors with opposite effects: a model for homeostatic control of autocrine and paracrine signalingB Ashby
Department of Pharmacology, Temple University Health Sciences Center, Philadelphia, PA 19140, USA
Biochem Pharmacol 55:239-46. 1998..Many organs and tissues express many of the prostaglandin receptors, and prostaglandins have diverse effects on individual organs and tissues...
- Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humansBrian J Dean
Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ 07065, USA
Drug Metab Dispos 35:283-92. 2007..Overall, the in vivo metabolism of MK-0524 is expected to proceed via glucuronidation, with minor contributions from oxidative pathways...
- EP1- and FP-mediated cross-desensitization of the alpha (alpha) and beta (beta) isoforms of the human thromboxane A2 receptorLeanne P Kelley-Hickie
Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland
Br J Pharmacol 142:203-21. 2004....
- Absorption, metabolism, and excretion of [(14)C]MK-0524, a prostaglandin D(2) receptor antagonist, in humansBindhu Karanam
Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ 07065, USA
Drug Metab Dispos 35:1196-202. 2007..Therefore, in humans, MK-0524 was eliminated primarily via metabolism to the acyl glucuronic acid conjugate, followed by excretion of the conjugate into bile and eventually into feces...
- The effect of MK-0524, a prostaglandin D(2) receptor antagonist, on prostaglandin D (2)-induced nasal airway obstruction in healthy volunteersA Van Hecken
Center for Clinical Pharmacology, UZ Gasthuisberg, K U Leuven, Herestraat 49, 3000 Leuven, Belgium
Eur J Clin Pharmacol 63:135-41. 2007..Intranasal challenge with PGD(2) can be a useful tool for evaluating DP-receptor antagonists...
- Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1E Lai
Department of Clinical Pharmacology, Merck Research Laboratories, Rahway, New Jersey, USA
Clin Pharmacol Ther 81:849-57. 2007..In conclusion, the DP1 receptor antagonist laropiprant was effective in suppressing both subjective and objective manifestations of niacin-induced vasodilation...
- GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushingZoltan Benyo
Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
J Clin Invest 115:3634-40. 2005..Our data clearly indicate that GPR109A mediates nicotinic acid-induced flushing and that this effect involves release of PGE(2) and PGD(2), most likely from immune cells of the skin...
- Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonistE Lai
Merck Research Laboratories, Rahway, New Jersey and West Point, Pennsylvania, USA
Clin Pharmacol Ther 83:840-7. 2008..Laropiprant has detectable off-target antagonist effects at the thromboxane A(2) receptor but no clinically significant effect on collagen-induced platelet aggregation or bleeding times with multiple doses up to 200 mg...
- Effects of aspirin when added to the prostaglandin D2 receptor antagonist laropiprant on niacin-induced flushing symptomsVictor Dishy
Daiichi Sankyo Pharma Development
J Clin Pharmacol 49:416-22. 2009..All treatments were safe and well tolerated. Coadministration of aspirin 325 mg daily with ER niacin 2 g/laropiprant 40 mg does not further reduce residual flushing symptoms associated with ER niacin 2 g/laropiprant 40 mg alone...
- Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitmentEric Chevalier
Department of Biology, Pfizer Global Research and Development, Fresnes, France
J Immunol 175:2056-60. 2005..These results suggest a nonredundant role of CRTH2 in restricting eosinophilia and allergic response in vivo...
- A novel angiogenic role for prostaglandin F2alpha-FP receptor interaction in human endometrial adenocarcinomasKurt J Sales
Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, United Kingdom
Cancer Res 65:7707-16. 2005..Finally, we confirmed that PGF2alpha could potentiate angiogenesis in endometrial adenocarcinoma explants by transactivation of the EGFR and induction of VEGF mRNA expression...
- Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout miceM Sonoshita
Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
Nat Med 7:1048-51. 2001....
- Suppression of protein kinase C signaling by the novel isoform for bovine PGF(2alpha) receptorY Ishii
Institute of Biological Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8572, Japan
Biochem Biophys Res Commun 285:1-8. 2001..Cotransfection of an excess amount of FP(a) markedly reduced FP-mediated PKC activity, suggesting that the novel FP isoform might play a role as a negative regulator to attenuate normal FP function...
- CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in miceRie Nomiya
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
J Immunol 180:5680-8. 2008..These results suggest that the PGD(2)-CRTH2 interaction is elevated following sensitization and plays a proinflammatory role in the pathophysiology of allergic rhinitis, especially pollinosis in mice...
- [Prostaglandin D2 in allergy: PGD2 has dual receptor systems]Hiroyuki Hirai
Department of Advanced Medicine and Development, BML, Inc, Kawagoe, Saitama, Japan
Nihon Yakurigaku Zasshi 123:15-22. 2004..The findings from these in vivo and vitro studies suggest that PGD(2) secreted from activated mast cells may be involved in the formation and/or maintenance of allergic inflammations through its dual receptor systems...
- Activation of the D prostanoid receptor 1 regulates immune and skin allergic responsesVeronique Angeli
Unite 547, Institut National de la Sante et de la Recherche Medicale, Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
J Immunol 172:3822-9. 2004..We propose that DP1 activation by specific agonists may represent a strategy to control cutaneous inflammatory Th2-associated diseases...
- PGD(2) DP1 receptor protects brain from ischemia-reperfusion injurySofiyan Saleem
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
Eur J Neurosci 26:73-8. 2007..Development of drugs to stimulate the DP1 receptor in brain could provide a new therapeutic strategy against cerebral ischemia and potentially other neurological conditions...
- Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptorsMagdalena Grill
Institute of Experimental and Clinical Pharmacology, Medical University Graz, Graz, Austria
J Neurochem 104:1345-57. 2008..The localization of the PGD2 receptors DP1 and CRTH in spinal cord neurons, particularly in neurons of lamina I and II involved in the processing of nociceptive stimuli, supports a role of PGD2 under inflammatory conditions...
- Prostaglandin signaling following seizuresJianxiong Jiang; Fiscal Year: 2013....
- cPLA2alpha and COX-2 in CholangiocarcinomaTong Wu; Fiscal Year: 2013..abstract_text> ..
- Role of Prostaglandin Receptors in StrokeSYLVAIN DORE; Fiscal Year: 2013..Such information is required to develop and test receptor agonist/antagonist interventions for potential use in clinical trials for hemorrhagic stroke. ..
- Role of prostaglandin F2a receptor (FP receptor) in hemorrhagic stroke.Shekher Mohan; Fiscal Year: 2013..Dr. Dore and others have successfully demonstrated the role of prostaglandin receptors in ischemic stroke;however this remains to be elucidated in hemorrhagic stroke...
- Roles of microglia and prostaglandin receptors in neuroprotectionNoel G Carlson; Fiscal Year: 2013..This work may identify new neuroprotective strategies centered on microglial responses and modulation of EP receptors. ..
- Validation of the PGE2 EP4 receptor as a therapeutic target in ADKatrin I Andreasson; Fiscal Year: 2010..In our recent studies, we have determined that different prostaglandin receptors have pro- or anti- inflammatory effects in models of neuroinflammation as well as protective or toxic ..
- Role of COX2 of Neuronal Origin in Blood-Brain Communication after status epileptRaymond J Dingledine; Fiscal Year: 2012....
- Prostaglandin Signaling Pathway in Liver CancerTong Wu; Fiscal Year: 2013..The proposed studies are expected to provide important therapeutic implications for the chemoprevention and treatment of human liver cancer. ..
- Prostaglandin Receptor Regulation of Kidney CancerYehia Daaka; Fiscal Year: 2013..Targeted disruption of EP4 signaling and inactivation of Rap may provide a window of opportunity to interfere with progression of kidney cancer to currently incurable advanced disease. ..
- Protective prostaglandin receptors in cerebral ischemiaKatrin I Andreasson; Fiscal Year: 2013..Our previous studies have focused on identifying which prostaglandin receptors mediate COX-2 neurotoxicity and we have determined that although several receptors do promote toxicity, a ..
- PROSTAGLANDIN RECEPTOR REGULATION IN THE CORPUS LUTEUMMilo Wiltbank; Fiscal Year: 2000..This will not only advance our current knowledge of reproductive physiology, but will allow for the rational development of contraceptives or infertility treatments that target prostaglandin action in the ovary. ..
- BIOACTIVE COMPOUNDS AND MEMBRANE PROTEINSKoji Nakanishi; Fiscal Year: 2000..The prostaglandin receptors will be studied by introducing photoaffinity labels into readily available prostaglandins by a general ..
- Ocular Inflammation-Chemical and Physiological AspectsCHRISTOPHER PATERSON; Fiscal Year: 2003..We will test the hypothesis that different subtypes of prostaglandin receptors mediate specific inflammatory responses in vivo...
- ALCOHOLIC EMBRYOPATHY & MATERNAL HYPERTENSIONRUSSELL MANKES; Fiscal Year: 1992....
- INSULIN AND PROSTACYCLIN IN ISCHEMIC HEART DISEASEASRU SINHA; Fiscal Year: 1990....
- Regulation of PAF Acetylhydrolase Expression by Oxidized PhospholipidsSUZANNE BARBOUR; Fiscal Year: 2009..The objective of this study is to delineate the molecular mechanisms of PAFAH induction by oxPL in hopes that this will uncover novel mechanisms for regulating the enzyme and thereby controlling cardiovascular disease. ..
- REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUMLeslie Myatt; Fiscal Year: 2006..The confocal microscopy will provide information on cellular localization of receptors and the promoter analyses will reveal potential regulatory sites for control of expression of uterine receptors at parturition. ..
- EICOSANOID MECHANISMS INITIATING NEUROGENIC INFLAMMATIONMICHAEL VASKO; Fiscal Year: 2004..This knowledge is critically important for understanding the process of neurogenic inflammation and in ultimately designing new drug therapies for the management of inflammatory diseases. ..
- REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUMLeslie Myatt; Fiscal Year: 1999..A necessary first step is the development of quality reagents to aid in this study and for further use in probing receptor structure/function relationships. ..
- Parathyroid Hormone and Osteoblast MitogenesisLouis Luttrell; Fiscal Year: 2005..The first Aim of this proposal is to characterize the molecular mechanisms whereby PTH and prostaglandin receptors regulate the activity of MAP kinase cascades in osteoblasts...
- SYNTHESIS OF ANTILEUKEMIC & TUMOR-PROMOTING TERPENOIDSDAVID WIEMER; Fiscal Year: 1990..Ultimately, this may lead to the ability to design second generation substances with enhanced antileukemic activity, and to a better understanding of the process of tumor promotion...
- Mechanisms of Ductus Arteriosus RegulationJOHN JEFFREY REESE; Fiscal Year: 2010..These studies will examine new roles for prostaglandins and their relationship with other vasoactive mediators during development. ..
- CYCLOOXYGENASE AND TUMORIGENESISDaniel Hwang; Fiscal Year: 2003..4) To determine whether prostaglandin receptors that activate adenylate cyclase are differentially expressed in the colon cancer cells as compared with ..
- CYCLOOXYGENASE AND PGE2 RECEPTOR FUNCTION IN SKIN CANCERAlice Pentland; Fiscal Year: 2004..EP receptor effects on keratinocyte proliferation, apoptosis and differentiation will be studied as markers of cutaneous neoplasia. ..
- Acquisition of a FLIPR 3 system (384-well Type B head)Heidi Hamm; Fiscal Year: 2004..and protease-activated receptors, targeting and trafficking of G protein-coupled receptors, glyceryl-prostaglandin receptors, neurotransmitter transporters and metabotropic receptors related to Parkinson's disease inter alia...
- MOLECULAR BASIS OF PRECONDITIONINGYiru Guo; Fiscal Year: 2005..protection will be systematically interrogated by targeted genetic disruption of all known prostaglandin receptors (DP, EP1, EP2, EP3, EP4, F, and IP receptors)...
- LIPIDS AND SIGNAL TRANSDUCTION IN NEURONSSTEVEN FEINMARK; Fiscal Year: 2002..and 8-KETE, identified "unusual" nicotine acetylcholine receptors with sequence similarity to prostaglandin receptors, and identified strong links between lipid metabolism and synaptic plasticity in models of LTP and LTD in ..
- Fatty Acid Effects on COX-2 Dependent Prostate CancerRussell Klein; Fiscal Year: 2005..COX2 mice. The fourth specific aim involves characterizing the prostaglandin receptors involved in prostaglandin regulation of cell proliferation, apoptosis, VEGF and matrix metalloprotease ..
- CHLORIDE CHANNELS AND GASTRIC ACID SECRETIONJohn Cuppoletti; Fiscal Year: 2003..These studies strive to address the fundamental questions regarding the molecules and mechanisms involved in regulated HCl secretion. ..
- MODELS OF ALZHEIMER'S DISEASEKatrin Andreasson; Fiscal Year: 2003..In Aim 3, we will test the effect of a selective cox-2 inhibitor on the development of a pathological AD phenotype in single, bigenic and trigenic mice generated in Aims 1 and 2. ..
- Role of Regulated CIC CI Channels in CI Secretion in CFJohn Cuppoletti; Fiscal Year: 2006..2 K channel in CF. This will also be studied in terms of CI transport, Na transport, CLCA2 function, inflammation and bacterial susceptibility. ..
- ROLE OF PGE2 RECEPTORS EP2 AND EP3 ON SENESCENCERaymond Konger; Fiscal Year: 2004..These studies will underscore how alterations of receptor expression serve to define the role of eicasonoids in diverse cellular functions. ..
- Role of Prostaglandins & Phospholipase A in melanocytesGlynis Scott; Fiscal Year: 2009..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
- Role of PPARgamma in ultraviolet stress responsesRaymond Konger; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Regulation and actions of NO in the cardiac plexusJEAN HARDWICK; Fiscal Year: 2005..In particular, it will provide important information concerning the regulation and of NO in the control of cardiac function. ..
- SIGNALING PATHWAYS IN CHEMICAL INDUCED OVOTOXICITYPatricia B Hoyer; Fiscal Year: 2010..This will lead to an appreciation of the global impact of the environment on the reproductive life span in women. ..
- ENVIRONMENTAL EPOXIDES--MECHANISMS OF OVOTOXICITYPatricia Hoyer; Fiscal Year: 2002..The results of these studies will provide greater insight as to the impact of exposure to ovotoxic environmental chemicals on reproductive health in women. ..
- NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONINSTEVEN YELLON; Fiscal Year: 2002....
- MAST CELL NERVE INTERACTIONS IN AIRWAYSBradley J Undem; Fiscal Year: 2010..The results may also shed new light on the complex pathophysiology of allergic airway diseases, i.e., asthma, and ultimately suggest new therapeutic strategies for treatment of these complex disorders. ..
- Regulation of Myoblast FusionGrace K Pavlath; Fiscal Year: 2010..Studies of the MR may lead to new strategies for manipulating myoblasts in disease, repair and aging and define novel therapeutic targets for enhancing muscle growth. ..
- ENHANCED TISSUE REGENERATION OF OROFACIAL MUSCLESGRACE PAVLATH; Fiscal Year: 2002....
- CADHERIN DYNAMICS AND GLAUCOMAW Daniel Stamer; Fiscal Year: 2010..Results obtained from these investigations will provide a basic understanding of the role of cadherin proteins in aqueous outflow resistance and uncover novel therapeutic targets for glaucoma therapy. ..
- ETHANOL SENSITIVITY OF NATIVE AND CLONED NMDA RECEPTORSJohn Woodward; Fiscal Year: 2009..Aim 3 will express ethanol-insensitive receptors identified in Aims 1 and 2 in neurons in vitro and in vivo to address which effects of ethanol are mediated by inhibition of NMDA receptors. ..
- BIOCHEMISTRY OF UTERINE HEPARAN SULFATE RECEPTORSDaniel Carson; Fiscal Year: 2006..In addition, we will examine the role(s) that HIP/L29 plays in vivo using transgenic mouse models. ..
- The effects of strain on vocal fold fibroblastsRyan Branski; Fiscal Year: 2004..Furthermore, it seeks to provide in vitro data in conjunction with the Sponsor's current NIH ROI. ..
- Role of Erythrocytes in Circulatory ControlRandy Sprague; Fiscal Year: 2004..abstract_text> ..
- Discovery of biomarkers of pulmonary hypertensionRubin Tuder; Fiscal Year: 2005..abstract_text> ..
- Prostanoid Modulation of Neuronal DeathNoel Carlson; Fiscal Year: 2005..abstract_text> ..
- Calcineurin in Prostaglandin Mediated Muscle GrowthGRACE PAVLATH; Fiscal Year: 2005..abstract_text> ..
- CYTOCHROME P450 EICOSANOIDS AND PULMONARY HEMODYNAMICSAlan Stephenson; Fiscal Year: 2002..abstract_text> ..
- Ovary Intact Murine Model for MenopausePatricia Hoyer; Fiscal Year: 2007..Characterization of the VCD-treated mouse will, therefore, make a profound contribution to the study of menopause-related pathologies and, therefore, to women's health. ..
- Mechanisms of ATP Release from RBC'sRandy Sprague; Fiscal Year: 2007..abstract_text> ..
- Compartmental analysis of proteomic biomarkers during intra-uterine infectionsPETA GRIGSBY; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- BRADYKININ IN ENTERIC NEUROIMMUNE COMMUNICATIONJACKIE WOOD; Fiscal Year: 2005..The overall goal of the study is to better understand the role of bradykinin in motility disturbances, diarrhea, abdominal pain and inflammation. ..
- Role of Cyclooxygenase stimulated Neovascularization in Diabetic NephropathyChuan Ming Hao; Fiscal Year: 2008..Pozzi's expertise in angiogenesis and Dr. Breyer's expertise in mouse models of diabetic nephropathy, and draws on their common interest in the prostanoid pathway in cell differentiation and survival. ..
- Regulation of Secretory Ion Channels in Colonic CryptsDAN HALM; Fiscal Year: 2009..Thus, this project will lead to greater insight into the regulatory control of colonic fluid secretion and likely to therapeutic interventions for patients with life-threatening secretory activity. ..
- Estrogen and Mechanisms of Cardiomyocyte ProtectionRichard Karas; Fiscal Year: 2009....
- Cellular and molecular regulation of muscle stem cellsGRACE PAVLATH; Fiscal Year: 2009..Studies of Sca-1 may lead to new strategies for manipulating myogenic stem cells in disease, repair and aging and define novel therapeutic targets for enhancing muscle growth. ..
- Renal Medullary COX2 in Blood Pressure RegulationChuan Ming Hao; Fiscal Year: 2009..Specific Aim III: To define the down-stream target of activated renal medullary COX2 expression. ..
- Prostease-activated receptor-2 in uterine contractilityYuri Vedernikov; Fiscal Year: 2004..The potential benefits of these studies include a better understanding of the mechanisms modulating uterine contractility, thereby improving our ability to control it clinically. ..