integrin alpha1beta1

Summary

Summary: Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.

Top Publications

  1. pmc Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor
    Pia Nyberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Exp Cell Res 314:3292-305. 2008
  2. pmc Structure of collagen receptor integrin α(1)I domain carrying the activating mutation E317A
    Matti Lahti
    Department of Biochemistry and Food Chemistry, University of Turku, Turku FI 20014, Finland
    J Biol Chem 286:43343-51. 2011
  3. pmc Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury
    Xiwu Chen
    Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University, Medical Center North, B3109, 1161 21st Ave, Nashville, TN 37212, USA
    Am J Pathol 165:617-30. 2004
  4. ncbi Integrin-mediated cell adhesion to type I collagen fibrils
    Johanna Jokinen
    Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla FI 40014, Finland
    J Biol Chem 279:31956-63. 2004
  5. pmc Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and arthritis
    A R de Fougerolles
    Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 105:721-9. 2000
  6. pmc Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression
    Xiwu Chen
    Department of Medicine, Division of Nephrology, Medical Center North B3109, Vanderbilt University, Nashville, TN 37232, USA
    Mol Cell Biol 30:3048-58. 2010
  7. pmc Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin α1β1 using collagen toolkits II and III
    Samir W Hamaia
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom
    J Biol Chem 287:26019-28. 2012
  8. ncbi Alterations in fibroblast alpha1beta1 integrin collagen receptor expression in keloids and hypertrophic scars
    Greg Szulgit
    Department of Biology, Hiram College, Hiram, Ohio, USA
    J Invest Dermatol 118:409-15. 2002
  9. pmc Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins
    O Langholz
    Department of Dermatology, University of Cologne, Germany
    J Cell Biol 131:1903-15. 1995
  10. pmc The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis
    Donald R Senger
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston 02215, USA
    Am J Pathol 160:195-204. 2002

Detail Information

Publications178 found, 100 shown here

  1. pmc Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor
    Pia Nyberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Exp Cell Res 314:3292-305. 2008
    ..Collectively, this data sheds more light into the anti-angiogenic mechanism of arresten...
  2. pmc Structure of collagen receptor integrin α(1)I domain carrying the activating mutation E317A
    Matti Lahti
    Department of Biochemistry and Food Chemistry, University of Turku, Turku FI 20014, Finland
    J Biol Chem 286:43343-51. 2011
    ..To conclude, the activated α(1)I domain represents a novel conformation of the αI domain, mimicking the structural state where the Arg(287)-Glu(317) ion pair has just broken during the integrin activation...
  3. pmc Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury
    Xiwu Chen
    Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University, Medical Center North, B3109, 1161 21st Ave, Nashville, TN 37212, USA
    Am J Pathol 165:617-30. 2004
    ..Thus, we have identified integrin alpha1beta1 as a modulator of glomerulosclerosis...
  4. ncbi Integrin-mediated cell adhesion to type I collagen fibrils
    Johanna Jokinen
    Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla FI 40014, Finland
    J Biol Chem 279:31956-63. 2004
    ....
  5. pmc Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and arthritis
    A R de Fougerolles
    Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 105:721-9. 2000
    ....
  6. pmc Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression
    Xiwu Chen
    Department of Medicine, Division of Nephrology, Medical Center North B3109, Vanderbilt University, Nashville, TN 37232, USA
    Mol Cell Biol 30:3048-58. 2010
    b>Integrin alpha1beta1 negatively regulates the generation of profibrotic reactive oxygen species (ROS) by inhibiting epidermal growth factor receptor (EGFR) activation; however, the mechanism by which it does this is unknown...
  7. pmc Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin α1β1 using collagen toolkits II and III
    Samir W Hamaia
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom
    J Biol Chem 287:26019-28. 2012
    ..These data confirm the selectivity of GFOGER for α2β1 and establish GLOGEN as a high affinity site for α1β1...
  8. ncbi Alterations in fibroblast alpha1beta1 integrin collagen receptor expression in keloids and hypertrophic scars
    Greg Szulgit
    Department of Biology, Hiram College, Hiram, Ohio, USA
    J Invest Dermatol 118:409-15. 2002
    ....
  9. pmc Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins
    O Langholz
    Department of Dermatology, University of Cologne, Germany
    J Cell Biol 131:1903-15. 1995
    ..The data presented here indicate that different signaling pathways exist leading to the three events discussed here, and that these pathways do not per se depend upon each other...
  10. pmc The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis
    Donald R Senger
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston 02215, USA
    Am J Pathol 160:195-204. 2002
    ..Collectively, these studies identify critical collaborative functions for the alpha(1)beta(1) and alpha(2)beta(1) integrins in supporting VEGF signal transduction, EC migration, and tumor angiogenesis...
  11. ncbi Prolyl hydroxylation of collagen type I is required for efficient binding to integrin alpha 1 beta 1 and platelet glycoprotein VI but not to alpha 2 beta 1
    Stéephanie Perret
    Institut de Biologie et Chimie des Proteines, CNRS UMR 5086, IFR128 Biosciences Lyon Gerland, 7 passage du Vercors, 69367 Lyon, Cedex 7, France
    J Biol Chem 278:29873-9. 2003
    ..These observations give new insights into the molecular basis of collagen-receptor interactions and offer new selective applications for the recombinant unhydroxylated collagen I...
  12. pmc Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy
    D Cosgrove
    Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska, USA
    Am J Pathol 157:1649-59. 2000
    ..that two different pathways, one mediated by transforming growth factor (TGF)-beta1 and the other by integrin alpha1beta1, affect Alport glomerular pathogenesis in distinct ways...
  13. ncbi The role of alpha1beta1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture
    L Racine-Samson
    Liver Center Laboratory, San Francisco General Hospital, and the Department of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 272:30911-7. 1997
    ..Although alpha2beta1 is capable of mediating contraction, its expression by myofibroblasts occurs largely, if not exclusively, in response to culture...
  14. ncbi Binding and docking of synthetic heterotrimeric collagen type IV peptides with alpha1beta1 integrin
    Barbara Saccà
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Chembiochem 3:904-7. 2002
  15. ncbi Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration
    Gilbert W Moeckel
    Renal Pathology Division, Dept of Pathology, Vanderbilt School of Medicine, Nashville, TN 37232 2561, USA
    Am J Physiol Renal Physiol 290:F223-31. 2006
    ..Utilizing inner medullary collecting duct cells, we demonstrate that the lack of integrin alpha1beta1 results in an impaired ability to induce the tonicity enhancer-binding protein TonEBP under hypertonic ..
  16. ncbi Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis
    H Gardner
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California USA 92037, USA
    J Cell Sci 112:263-72. 1999
    b>Integrin alpha1beta1 is a collagen receptor predominantly found in mesenchymal tissues. Mice lacking this receptor are viable...
  17. ncbi Favourable melanoma prognosis associated with the expression of the tumour necrosis factor receptor and the alpha1beta1 integrin: a preliminary report
    A Gilhar
    The B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Melanoma Res 7:486-95. 1997
    ....
  18. pmc Collagen-binding integrin alpha1beta1 regulates intestinal inflammation in experimental colitis
    Christian F Krieglstein
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    J Clin Invest 110:1773-82. 2002
    ..Therapeutic strategies designed to disrupt such interactions may prove beneficial in treating intestinal inflammation...
  19. ncbi Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment
    Changqing Yang
    Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 63:8312-7. 2003
    ....
  20. pmc Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin
    Akulapalli Sudhakar
    Cell Signaling and Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    J Clin Invest 115:2801-10. 2005
    ..Collectively, the above data indicate that alpha1(IV)NC1 is a potential therapeutic candidate for targeting tumor angiogenesis...
  21. ncbi Expression of collagen-binding integrin receptors in the mammalian sclera and their regulation during the development of myopia
    Neville A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia 3010
    Invest Ophthalmol Vis Sci 47:4674-82. 2006
    ..This study identified the major collagen-binding integrin receptors in the mammalian sclera and investigated their mRNA expression during the development of and recovery from experimental myopia...
  22. doi Integrin alpha1beta1 is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo
    Alejandro Rodriguez
    Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Uppsala, Sweden
    J Cell Mol Med 13:3449-62. 2009
    ....
  23. ncbi Collagen I initiates endothelial cell morphogenesis by inducing actin polymerization through suppression of cyclic AMP and protein kinase A
    Mary C Whelan
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:327-34. 2003
    ....
  24. ncbi Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP
    Elina Mattila
    VTT Technical Research Centre of Finland, Medical Biotechnology and University of Turku Centre for Biotechnology, Turku FIN 20520, Finland
    Nat Cell Biol 7:78-85. 2005
    ..These data are the first demonstration of the regulation of TCPTP activity in vivo and represent a new molecular paradigm of integrin-mediated negative regulation of receptor tyrosine kinase signalling...
  25. ncbi Integrin alpha1beta1 mediates collagen induction of MMP-13 expression in MC615 chondrocytes
    Marie Claire Ronzière
    Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS UCBL, IFR 128 Biosciences Lyon Gerland, 7 passage du Vercors, 69367 Lyon Cedex 07, France
    Biochim Biophys Acta 1746:55-64. 2005
    ..Interestingly, bone morphogenetic protein (BMP)-2 opposed this induction, an effect that may be related to a role of BMP-2 in the maintenance of cartilage matrix...
  26. ncbi Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1
    S Makihira
    Department of Prosthetic Dentistry, Hiroshima University School of Dentistry, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    J Biol Chem 274:11417-23. 1999
    ..is a potent adhesion factor for chondrocytes, particularly in the presence of type II collagen, and that integrin alpha1beta1 is involved in CMP-mediated cell adhesion and spreading...
  27. pmc Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation
    Xiwu Chen
    Department of Medicine, Division of Nephrology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Cell Biol 27:3313-26. 2007
    ..Thus, our study demonstrates that integrin alpha1beta1-EGFR cross talk is a key step in negatively regulating Rac1 activation, ROS production, and excessive ..
  28. ncbi A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1
    Jiyeun Kate Kim
    The Center for Extracellular Matrix Biology, Texas A and M University Health Science Center, Institute of BioScience and Technology, Houston, 77030, USA
    J Biol Chem 280:32512-20. 2005
    ..Furthermore, the GROGER-containing peptide supported adhesion of human lung fibroblast cells when coated on a culture dish. Thus, we have identified a novel high affinity binding sequence for the collagen-binding integrin I domains...
  29. ncbi Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica, Patologia Università di Perugia, Italy
    Immunity 17:769-80. 2002
    ..We investigated the role of the collagen binding integrin alpha1beta1 in a model of colitis. alpha1beta1 was expressed on lamina propria T cells and monocytes during disease...
  30. pmc Integrin alpha1beta1 (VLA-1) mediates adhesion of activated intraepithelial lymphocytes to collagen
    A I Roberts
    Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, NY, USA
    Immunology 97:679-85. 1999
    ..Therefore, IELs bind collagen through integrin alpha1beta1 after protein kinase C activation. Adhesion is modulated by divalent cations.
  31. ncbi RGD-CAP ((beta)ig-h3) enhances the spreading of chondrocytes and fibroblasts via integrin alpha(1)beta(1)
    S Ohno
    Department of Orthodontics, Hiroshima University School of Dentistry, Hiroshima 734 8553, Japan
    Biochim Biophys Acta 1451:196-205. 1999
    ..Accordingly, an RGD-CAP fragment, which carries a deletion in the C-terminal region containing the RGD motif, was still capable of stimulating cell spreading...
  32. ncbi Functional overlap and cooperativity among alphav and beta1 integrin subfamilies during skin angiogenesis
    Carole A Perruzzi
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Invest Dermatol 120:1100-9. 2003
    ....
  33. ncbi Effects of anti-alpha1 integrin subunit antibody on anti-Thy-1 glomerulonephritis
    Shoji Kagami
    Department of Pediatrics, School of Medicine, University of Tokushima, Japan
    Lab Invest 82:1219-27. 2002
    ..Platelet-derived growth factor-BB may be involved in early collagen matrix reorganization leading to pathologic mesangial remodeling in this GN model...
  34. ncbi Integrin-mediated preadipocyte adhesion and migration on laminin-1
    Charles W Patrick
    Laboratory of Reparative Biology and Bioengineering, Department of Plastic Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 443, Houston, TX 77030, USA
    Ann Biomed Eng 31:505-14. 2003
    ..These results strongly support the hypothesis that preadipocyte adhesion to and migration on laminin-1 substrata are regulated, in part, by integrins...
  35. ncbi Endothelin-1 is a potent stimulator of alpha1beta1 integrin-mediated collagen matrix remodeling by rat mesangial cells
    A Kitamura
    Department of Pediatrics, School of Medicine, University of Tokushima, Kuramoto cho 3 chome, Tokushima 770 8504, Japan
    Biochem Biophys Res Commun 299:555-61. 2002
    ..We therefore conclude that ET is a potential molecule inducing pathological collagen matrix remodeling observed in progressive GN...
  36. ncbi Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis
    Dong Chen
    Division of Nephrology, Department of Medicine, Vanderbilt Medical Center, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 287:F602-11. 2004
    ..This suggests that temporal and spatial changes in integrin expression could help organize the pattern of branching morphogenesis of the developing collecting system in vivo...
  37. ncbi Role of the I-domain in collagen binding specificity and activation of the integrins alpha1beta1 and alpha2beta1
    A Kern
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Cell Physiol 176:634-41. 1998
    ..This ion requirement was not found in CHO cells, implicating the I domain in cell type-specific activation of integrins...
  38. ncbi Lymphocytes expressing alpha1beta1 integrin (very late antigen-1) in peripheral blood of patients with arthritis are a subset of CD45RO(+) T-cells primed for rapid adhesion to collagen IV
    Ilan Bank
    Department of Medicine F, Chaim Sheba Medical Center and Tel Aviv University, Tel Hashomer, 52621, Israel
    Clin Immunol 105:247-58. 2002
    ..These results suggest that VLA-1(+) CD45RO(+) T-cells in patients with arthritis could play a role in both systemic and local inflammation by rapidly adhering to collagen IV...
  39. pmc Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins
    D R Senger
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 94:13612-7. 1997
    ....
  40. ncbi Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen
    Ilan Bank
    Department of Medicine F, Chaim Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    Cell Immunol 223:35-45. 2003
    ..These results suggest new ways for functional modulation of activated T-cells interacting with collagen...
  41. ncbi The small Gtpase ras is involved in growth factor-regulated expression of the alpha1 integrin subunit in PC12 cells
    K Danker
    , , Germany
    Biol Chem 382:969-72. 2001
    ..In cells expressing the dominant-negative RasN17 variant, alpha1 integrin expression and alpha1beta1-specific adhesion remain unchanged in response to both growth factors...
  42. ncbi Detection of soluble alpha1 integrin in human serum
    I Bank
    Department of Medicine, Chaim Sheba Medical Center, Sackler School of Medicine, Israel
    J Lab Clin Med 134:599-604. 1999
    ..These results suggest, for the first time, that salpha1 are present in healthy and diseased human serum...
  43. ncbi Distribution of the collagen-binding integrin alpha10beta1 during mouse development
    L Camper
    Department of Cell and Molecular Biology, Lund University, Sweden
    Cell Tissue Res 306:107-16. 2001
    ..In conclusion, we found that integrin alpha10beta1 was a major collagen-binding integrin during cartilage development and in mature hyaline cartilage. In addition, we found that alpha10beta1 was present in some fibrous tissues...
  44. ncbi Modulation of alpha1beta1 integrin mediated adhesion of hepatocytes to collagen IV and laminin by divalent cations
    B Menon
    Department of Biochemistry, University of Kerala, Kariavattom, Trivandrum, India
    Indian J Biochem Biophys 38:159-65. 2001
    ....
  45. ncbi The alpha 1 beta 1 and alpha E beta 7 integrins define a subset of dendritic cells in peripheral lymph nodes with unique adhesive and antigen uptake properties
    Jonathan T Pribila
    Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 172:282-91. 2004
    ....
  46. ncbi The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection
    Steven J Ray
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester, Rochester, NY 14642, USA
    Immunity 20:167-79. 2004
    ..This suggests that VLA-1 is responsible for retaining protective memory CD8 T cells in the lung and other tissues via attachment to the extracellular matrix...
  47. ncbi Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen
    P Nykvist
    Department of Biological and Environmental Science, University of Jyvaskyla, FIN 40351 Jyvaskyla, Finland
    J Biol Chem 275:8255-61. 2000
    ..However, despite the fact that CHO-alpha1beta1 cells could not spread on type II collagen alpha(1)I domain could bind to this collagen type. Thus, the cell spreading on collagens may also be regulated by factors other than the integrins...
  48. ncbi Collagen IV regulates Caco-2 migration and ERK activation via alpha1beta1- and alpha2beta1-integrin-dependent Src kinase activation
    Matthew A Sanders
    Department of Surgery, Wayne State University, Detroit, MI 48201 1932, USA
    Am J Physiol Gastrointest Liver Physiol 286:G547-57. 2004
    ..Additionally, these results suggest Src regulates Caco-2 migration on collagen IV primarily through ERK-independent pathways...
  49. pmc Type VIII collagen stimulates smooth muscle cell migration and matrix metalloproteinase synthesis after arterial injury
    G Hou
    Terrence Donnelly Research Laboratories, Division of Cardiology, St Michael s Hospital, Department of Medicine, Toronto, Ontario, Canada
    Am J Pathol 156:467-76. 2000
    ....
  50. ncbi Phospholipase Cgamma binds alpha1beta1 integrin and modulates alpha1beta1 integrin-specific adhesion
    Dörte Vossmeyer
    Institut fur Molekularbiologie und Biochemie, Freie Universitat Berlin, Arnimallee 22, D 14195 Berlin Dahlem, Germany
    J Biol Chem 277:4636-43. 2002
    ..Cells lacking the conserved domain of the alpha(1) subunit fail to respond to the PLC inhibition, indicating that this domain is necessary for PLC-dependent adhesion modulation of alpha(1)beta(1) integrin...
  51. ncbi Collagen-binding I domain integrins--what do they do?
    Donald E Gullberg
    Department of Medical Biochemistry and Microbiology, Biomedical Center, Box 582, Uppsala University, S 75123 Uppsala, Sweden
    Prog Histochem Cytochem 37:3-54. 2002
    ..In this review we will describe what is currently known about the collagen-binding integrins and discuss their biological functions...
  52. ncbi Adaptor protein-2 exhibits alpha 1 beta 1 or alpha 6 beta 1 integrin-dependent redistribution in rhabdomyosarcoma cells
    Nikhat D Boyd
    Department of Chemistry, University of Western Ontario, London, Ontario N6A 5B7, Canada
    Biochemistry 41:7232-40. 2002
    ..Interestingly, alpha(6)beta(1) integrins are not located in coated pits, demonstrating that integrin colocalization with AP-2 is not necessary to induce redistribution of AP-2...
  53. ncbi Expression and functional importance of collagen-binding integrins, alpha 1 beta 1 and alpha 2 beta 1, on virus-activated T cells
    Susanne Ø Andreasen
    Institute of Medical Microbiology and Immunology, Panum Institute, Copenhagen, Denmark Biogen, Cambridge, MA 02142, USA
    J Immunol 171:2804-11. 2003
    ....
  54. ncbi Synthetic heterotrimeric collagen peptides as mimics of cell adhesion sites of the basement membrane
    Christian Renner
    Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Biopolymers 76:34-47. 2004
    ..Optimal local breathing of the rod-shaped collagens is apparently crucial for selective recognition by proteins interacting with these main components of the extracellular matrix...
  55. pmc Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin
    Neung Seon Seo
    Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:8811-8. 2008
    ....
  56. ncbi Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis
    Kallech Ziri Olfa
    Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunis Belvedere, Tunisie
    Lab Invest 85:1507-16. 2005
    ..This disintegrin also affected adhesion and migration of endothelial cells and exhibited an anti-angiogenic effect in vivo when using the 8-day-old embryo chick chorioallantoic membrane model...
  57. pmc Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer
    Ines Macias-Perez
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Veterans Affairs Hospital, Nashville, Tennessee 37232, USA
    Cancer Res 68:6127-35. 2008
    The collagen IV binding receptor integrin alpha1beta1 has been shown to regulate lung cancer due to its proangiogenic properties; however, it is unclear whether this receptor also plays a direct role in promoting primary lung tumors...
  58. ncbi Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains
    Johannes A Eble
    Institute for Physiological Chemistry and Pathobiochemistry, Muenster University Hospital, Waldeyerstrasse 15, 48149 Muenster, Germany
    J Biol Chem 281:25745-56. 2006
    ....
  59. ncbi Integrin alpha2beta1 mediates the anti-angiogenic and anti-tumor activities of angiocidin, a novel tumor-associated protein
    Yamini Sabherwal
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Exp Cell Res 312:2443-53. 2006
    ..Our results provide support for the concept that targeting matrix-cell interactions is a viable strategy for the development of anti-cancer therapeutics...
  60. ncbi Matrilins mediate weak cell attachment without promoting focal adhesion formation
    Henning H Mann
    Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    Matrix Biol 26:167-74. 2007
    ..deficient in beta1 integrins are able to adhere, although weaker, and matrilins do not bind the soluble integrin alpha1beta1 and alpha2beta1 ectodomains...
  61. ncbi Determination of the ligand-binding specificities of the alpha2beta1 and alpha1beta1 integrins in a novel 3-dimensional in vitro model of pancreatic cancer
    John J Grzesiak
    Department of Surgery, University of California San Diego, San Diego, CA, USA
    Pancreas 34:220-8. 2007
    ..The aim of the present study was to determine the ligand-binding specificities of the alpha2beta1 and alpha1beta1 integrins using a novel 3D in vitro model of pancreatic cancer...
  62. ncbi Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection
    Martin Richter
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:4506-16. 2007
    ..These observations suggest that CD4 T cell interaction with the tissue microenvironment is distinct from CD8 T cells and support the concept that CD4+ T cells in peripheral tissues are regulated differently than the CD8 subset...
  63. ncbi Adrenocortical zonation factor 1 is a novel matricellular protein promoting integrin-mediated adhesion of adrenocortical and vascular smooth muscle cells
    Dan Li
    Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, Tokyo, Japan
    FEBS J 274:2506-22. 2007
    ..Collectively with the putative role of AZ-1 in the adrenocortical zonation, we propose that AZ-1 potentially regulates functions of adrenocortical and VSM cells by modulating cell-matrix interactions...
  64. ncbi A novel subcellular collagen organization process visualized by total internal reflection fluorescence microscopy
    Erik F Young
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    Cell Commun Adhes 14:169-80. 2007
    ..Cells expressing alpha1beta1 also perform this collagen organization process, but less proficiently. This work will provide a basis for subsequent studies of cell-mediated collagen fibril assembly...
  65. doi Integrins and dystroglycan regulate astrocyte wound healing: the integrin beta1 subunit is necessary for process extension and orienting the microtubular network
    Huashan Peng
    Centre for Research in Neuroscience, McGill University Health Centre, Montreal, Quebec, Canada H3G 1A4
    Dev Neurobiol 68:559-74. 2008
    ..Functionally, inhibitory antibodies to DG and integrin alpha1beta1 or the RGD peptide all inhibit process extension, showing that ligand engagement of integrins and DG ..
  66. ncbi Collagen receptor integrins: rising to the challenge
    K D McCall-Culbreath
    Department of Microbiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Drug Targets 9:139-49. 2008
    ..Finally, we will elucidate the interesting and sometimes overlapping roles for alpha1beta1 and alpha2beta1 integrins in disease and will propose potential stategies to therapeutically target these receptors to alleviate or treat disease...
  67. ncbi The role of the I domain in ligand binding of the human integrin alpha 1 beta 1
    A Kern
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    J Biol Chem 269:22811-6. 1994
    ..Since a previously reported mutation of a homologous Asp in the Mac-1 I domain has similar consequences, these results suggest a central role for the I domain in ligand recognition for all integrin alpha subunits containing this domain...
  68. ncbi Basement membrane reconstruction in human skin equivalents is regulated by fibroblasts and/or exogenously activated keratinocytes
    Abdoelwaheb El Ghalbzouri
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 124:79-86. 2005
    ....
  69. ncbi Transforming growth factor-beta1 stimulates collagen matrix remodeling through increased adhesive and contractive potential by human renal fibroblasts
    Shuji Kondo
    Department of Pediatrics, School of Medicine, University of Tokushima, Kuramoto cho 3 chome, Tokushima 770 8503, Japan
    Biochim Biophys Acta 1693:91-100. 2004
    ....
  70. ncbi The laminin alpha2-chain short arm mediates cell adhesion through both the alpha1beta1 and alpha2beta1 integrins
    H Colognato
    Department of Pathology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 272:29330-6. 1997
    ....
  71. ncbi Structural determinants of the selectivity of KTS-disintegrins for the alpha1beta1 integrin
    Dariusz G Kisiel
    Center for Neurovirology and Cancer Biology, Temple University, College of Science and Technology, 1900 N, 12th Street, Philadelphia, PA 19122, USA
    FEBS Lett 577:478-82. 2004
    ....
  72. pmc Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor cells: impact on tumor recurrence and malignancy
    Tobias Engl
    Zentrum der Chirurgie, Klinik für Urologie und Kinderurologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    BMC Cancer 5:4. 2005
    ..We therefore investigated the adhesion capacity of colon, pancreas, prostate and kidney carcinoma cell lines to endothelium, as well as their beta1 integrin expression profile before and after MMF treatment...
  73. ncbi Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice
    Kitty Schapira
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1917-24. 2005
    Adhesive interactions between cells and the extracellular matrix play an important role in inflammatory diseases like atherosclerosis. We investigated the role of the collagen-binding integrin alpha1beta1 in atherosclerosis.
  74. ncbi Human skin mast cells express functional beta 1 integrins that mediate adhesion to extracellular matrix proteins
    M Columbo
    Division of Clinical Immunology, University of Naples Federico II School of Medicine, Italy
    J Immunol 154:6058-64. 1995
    ..Interactions between these beta 1 integrins and extracellular matrix proteins may be involved in perivascular tissue localization of human mast cells in vivo...
  75. ncbi Adhesion molecules VLA-1 to VLA-6 define discrete stages of peripheral B lymphocyte development and characterize different types of B cell neoplasia
    P Moller
    Institute of Pathology, University of Heidelberg, Germany
    Leukemia 6:256-64. 1992
    ..With respect to the well-known clinical characteristics of the B cell malignancies examined, the leukemic phenotype might crucially depend on the presence of VLA-5...
  76. ncbi Tumour progression and metastatic behaviour in vivo correlates with integrin expression on melanocytic tumours
    D Schadendorf
    Department of Dermatology, University Hospital Rudolf Virchow, FU Berlin, Germany
    J Pathol 170:429-34. 1993
    ....
  77. ncbi Exposure to vinblastine modulates beta 1 integrin expression and in vitro binding to extracellular matrix molecules in a human renal carcinoma cell line
    S Duensing
    Department of Hematology, Hannover University Medical School, Germany
    Invasion Metastasis 16:65-72. 1996
    ..Future studies will be needed to characterize the clinical relevance of MDR-associated changes in tumor cells...
  78. ncbi Very late antigen (VLA) expression in various forms of epidermolysis bullosa simplex
    V Nazzaro
    I Clinica Dermatologica, University of Milan IRCCS, Ospedale Maggiore, Italy
    Arch Dermatol Res 283:1-4. 1991
    ..Our data show that anti-VLA-3 and anti-VLA-6 can usefully be utilized in diagnostic immunomapping studies of EBs...
  79. pmc T-cell activation profiles in different granulomatous interstitial lung diseases--a role for CD8+CD28(null) cells?
    M Heron
    Center for Interstitial Lung Diseases, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands
    Clin Exp Immunol 160:256-65. 2010
    ..In sarcoidosis, blood CD8+CD28(null) cells might be a new biomarker for disease severity but needs further investigation...
  80. ncbi Distribution of beta 1, alpha 1, alpha 2 and alpha 3 integrin chains in basal cell carcinomas
    G W Stamp
    ICRF RCS Histopathology Unit, London
    J Pathol 163:307-13. 1991
    ....
  81. pmc Triggering through CD16 or phorbol esters enhances adhesion of NK cells to laminin via very late antigen 6
    A Gismondi
    Department of Experimental Medicine, University of Rome, Italy
    J Exp Med 176:1251-7. 1992
    ..The expression of VLA-6 on NK cells and the modulation of its avidity by activating stimuli may be relevant for NK cell migration and tissue location during inflammation or immune response...
  82. pmc Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases
    K Koretz
    Institute of Pathology, Heidelberg University, FRG
    Am J Pathol 138:741-50. 1991
    ..The down regulation/loss of VLA proteins in a subset of epithelial colon tumors might cause a disturbed cell-cell/cell-matrix interaction that might augment the invasive property of their cells...
  83. ncbi Cellular receptors for matrix proteins in normal human kidney and human mesangial cells
    F G Cosio
    Department of Internal Medicine and Pathology, Ohio State University, Columbus
    Kidney Int 38:886-95. 1990
    ..MC FN receptors (VLA-5) mediate the binding of MC to FN and could mediate the phagocytosis of FN coated antigen or immune complexes by mesangial cells...
  84. ncbi VLA-2 is the integrin used as a collagen receptor by leukocytes
    R Goldman
    Macrophage Laboratory, Imperial Cancer Research Fund, London, Great Britain
    Eur J Immunol 22:1109-14. 1992
    ..However, LFA-1, CR3 and p150,95 showed no collagen binding activity, suggesting that the I domain has another function...
  85. ncbi Specific overproduction of very late antigen 1 integrin in two human neuroblastoma cell lines selected for resistance to detachment by an Arg-Gly-Asp-containing synthetic peptide
    S Dedhar
    Department of Advanced Therapeutics, Cancer Control Agency of British Columbia, Vancouver, Canada
    J Biol Chem 264:4832-6. 1989
    ....
  86. ncbi Expression of beta 1 integrins in human dental pulp in vivo: a comparative immunohistochemical study on healthy and chronic marginal periodontitis samples
    F Tasman
    Department of Endodontics, Faculty of Dentistry, University of Hacettepe, 06100 Sihhiye, Ankara, Turkey
    Int Endod J 34:11-5. 2001
    ....
  87. ncbi Differential expression of very late activation antigen-3 (VLA-3)/VLA-4 in B-cell non-Hodgkin lymphoma and B-cell chronic lymphocytic leukemia
    L Baldini
    Department of Hematology, Centro G Marcora, Ospedale Maggiore IRCCS, Milan, Italy
    Blood 79:2688-93. 1992
    ....
  88. ncbi Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes
    Tomoko Yonezawa
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
    Glia 58:755-67. 2010
    ..Using function-blocking antibodies, we found that the effect of type IV collagen was attributed to integrin alpha1beta1 in primary astrocytes...
  89. ncbi Collagen type I modulates the platelet-derived growth factor (PDGF) regulation of the growth and expression of beta1 integrins by rat mesangial cells
    S Kagami
    School of Medicine, University of Tokushima, Tokushima, 770 0042, Japan
    Biochem Biophys Res Commun 252:728-32. 1998
    ..A spatial interaction between MCs and pathological collagen I in GN may influence the PDGF regulation of the MC phenotype regarding the cell growth and the expression of beta1 integrins...
  90. ncbi Recovery of purification-associated reduction in antigen-induced histamine release from rat peritoneal mast cells
    N Inagaki
    Department of Pharmacology, Gifu Pharmaceutical University, Japan
    Biol Pharm Bull 24:829-34. 2001
    ..Adhesion molecules such as ICAM-1, LFA-1 and VLA are not involved...
  91. ncbi [Expression of beta 1 integrins in normal B lymphocytes at different stages of development and in B cell neoplasias]
    A Eichelmann
    Pathologisches Institut,
    Verh Dtsch Ges Pathol 76:230-6. 1992
    ..Thus, FCCL although roughly corresponding to FC, tended to aberrantly express VLA-3 and/or VLA-4. Burkitt's lymphoma resembled FCCL but expressed VLA-4 more frequently and at higher levels.(ABSTRACT TRUNCATED AT 250 WORDS)..
  92. ncbi Expression of functional very late antigen-alpha 1, -alpha 2, -alpha 3 and -alpha 6 integrins on Ewing's sarcoma and primitive peripheral neuroectodermal tumour cells and modulation by interferon-gamma and tumour necrosis factor-alpha
    F van Valen
    Department of Paediatric Haematology and Oncology, , , Germany
    Eur J Cancer 30:2119-25. 1994
    ..Furthermore, our data indicate that IFN gamma- and TNF alpha-mediated alteration in the level of expression of distinct VLAs on ES and pPNET cells is correlated with changes in the adhesive behaviour of these tumour cells...
  93. ncbi Regulation of proteins in the VLA cell substrate adhesion family: influence of cell growth conditions on VLA-1, VLA-2, and VLA-3 expression
    E Fingerman
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    Exp Cell Res 177:132-42. 1988
    ..Elevation of VLA-1/VLA-2 and VLA-1/VLA-3 ratios is generally associated with quiescence and is not due just to serum deprivation since density arrest of cells at confluence had similar effects on these ratios...
  94. ncbi In vivo distribution of integrins in renal cell carcinoma: integrin-phenotype alteration in different degrees of tumor differentiation and VLA-2 involvement in tumor metastasis
    G Anastassiou
    Department of Hematology Oncology, Medizinische Hochschule Hannover, Germany
    Cancer Biother 10:287-92. 1995
    ..005). Our results suggest that VLA-2 integrin is involved in metastasis of RCC and that poorly differentiated tumor cells have a different integrin phenotype when compared to normal or highly differentiated tumor cells...
  95. ncbi Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines
    M E Hemler
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 264:6529-35. 1989
    ..The beta 4 subunit may be of major importance because (i) it is highly abundant on the surface of colon carcinoma cell lines, and (ii) it is highly immunogenic relative to other surface proteins...
  96. ncbi Identification of collagen and laminin receptor integrins on murine T lymphocytes
    S Miyake
    Division of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Immunol 24:2000-5. 1994
    ..These results indicate that VLA-1 and VLA-2 play an important role in regulating adhesion and cytokine production of activated T cells...
  97. ncbi Flow cytometric analysis of surface antigens on human conjunctival epithelial cells
    T Fujihara
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    Ophthalmic Res 29:103-9. 1997
    ..Our study suggests that these techniques may aid in identifying changes in the expression levels of various surface antigens on conjunctival epithelial cells that could occur in ocular surface disease...
  98. ncbi Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice
    Michihisa Zemmyo
    The Scripps Research Institute, La Jolla, California, USA
    Arthritis Rheum 48:2873-80. 2003
    ..Mice with targeted inactivation of the integrin alpha1 gene (alpha1-KO mice) provide a model that can be used to address the role of cell-matrix interactions in cartilage homeostasis and osteoarthritis (OA) pathogenesis...
  99. ncbi [Is chronic graft rejection the reason for degenerative changes in allogeneic and xenogeneic heart valve prostheses: immunohistochemical evaluation of inflammatory factors]
    Mathias Wilhelmi
    Abt f Thorax, Herz und Gefässchirurgie Medizinische Hochschule Hannover Carl Neuberg Strasse 1 30627 Hannover, Germany
    Z Kardiol 91:825-32. 2002
    ..Although many efforts have been made to identify underlying mechanisms, many questions remain unanswered. Here we evaluate immunological factors and their potential role in biological heart valve destruction...
  100. ncbi Expression patterns of integrin receptors and extracellular matrix proteins in chronic rejection of human liver allografts
    G Demirci
    , Medizinische Hochschule Hannover, Germany
    Transpl Immunol 7:229-37. 1999
    ....
  101. ncbi Human platelet alloantigens Bra/Brb are expressed on the very late activation antigen 2 (VLA-2) of T lymphocytes
    S Santoso
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Federal Republic of Germany
    Hum Immunol 25:237-46. 1989
    ..Our results provide evidence for the expression of the Bra/Brb platelet alloantigen system on VLA-2 antigens of activated T lymphocytes and demonstrate a genetic polymorphism of VLA-2 molecules on both cell lines...

Research Grants74

  1. Role of a3a4a5(IV) collagen in podocyte behavior
    Corina Borza; Fiscal Year: 2005
    ..abstract_text> ..
  2. Pivotal role of VLA-1 in CD8 T cell retention & survival
    David Topham; Fiscal Year: 2007
    ..We will also test the prediction that the VLA-1+ memory T cells are functionally distinct and important for secondary immune protection. [unreadable] [unreadable]..
  3. Monocyte Traffic and Neuropathogenesis of AIDS
    Kenneth Williams; Fiscal Year: 2006
    ....
  4. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2007
    ....
  5. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2009
    ....
  6. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2009
    ....
  7. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2009
    ....
  8. Molecular regulation of lymphangiogenesis in corneal alloimmunity
    Lu Chen; Fiscal Year: 2010
    ....
  9. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    Lenore Pereira; Fiscal Year: 2003
    ..expression of two functionally important stage-specific antigens nonclassical MHC class Ib HLA-G and integrin alpha1beta1. Moreover, the invasion competence of infected CTBs in vitro was dramatically impaired as was the ..
  10. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    Lenore Pereira; Fiscal Year: 2002
    ..expression of two functionally important stage-specific antigens nonclassical MHC class Ib HLA-G and integrin alpha1beta1. Moreover, the invasion competence of infected CTBs in vitro was dramatically impaired as was the ..
  11. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    Lenore Pereira; Fiscal Year: 2000
    ..expression of two functionally important stage-specific antigens nonclassical MHC class Ib HLA-G and integrin alpha1beta1. Moreover, the invasion competence of infected CTBs in vitro was dramatically impaired as was the ..
  12. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    Lenore Pereira; Fiscal Year: 2004
    ..expression of two functionally important stage-specific antigens nonclassical MHC class Ib HLA-G and integrin alpha1beta1. Moreover, the invasion competence of infected CTBs in vitro was dramatically impaired as was the ..
  13. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    Lenore Pereira; Fiscal Year: 2001
    ..expression of two functionally important stage-specific antigens nonclassical MHC class Ib HLA-G and integrin alpha1beta1. Moreover, the invasion competence of infected CTBs in vitro was dramatically impaired as was the ..
  14. The Immunobiology of VLA-1 on Subsets of Human T Cells
    Ilan Bank; Fiscal Year: 2003
    ..4) To study the effects of anti-VLA-1 immuno-therapy on functionally relevant auto-aggressive CD4+ TH1 in vivo in mouse models of experimental allergic encephalomyelitis (EAE). ..
  15. REGULATION OF DIFFERENTIATION IN HEPATOCYTES IN VITRO
    Harriet Isom; Fiscal Year: 1993
    ..We will continue to use in vitro hepatocyte systems to study differences in gene expression that occur during the process of transformation and to unravel the cellular and molecular mechanisms underlying these changes...
  16. Targeting alfa 1beta1 integrin in cancer development
    Cezary Marcinkiewicz; Fiscal Year: 2007
    ..abstract_text> ..
  17. Targeting alfa 1beta1 integrin in cancer development
    Cezary Marcinkiewicz; Fiscal Year: 2004
    ..abstract_text> ..
  18. Targeting alfa 1beta1 integrin in cancer development
    Cezary Marcinkiewicz; Fiscal Year: 2005
    ..abstract_text> ..
  19. Targeting alfa 1beta1 integrin in cancer development
    Cezary Marcinkiewicz; Fiscal Year: 2006
    ..abstract_text> ..
  20. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Leonard Chess; Fiscal Year: 2003
    ..In addition, we plan new basic studies of the control of the autoreactive T cell repertoire in autoimmune disease by analysis of EAE in the mouse and studies of human regulatory cells in TIDM. ..
  21. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Leonard Chess; Fiscal Year: 2005
    ..In addition, we plan new basic studies of the control of the autoreactive T cell repertoire in autoimmune disease by analysis of EAE in the mouse and studies of human regulatory cells in TIDM. ..
  22. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Leonard Chess; Fiscal Year: 2006
    ..In addition, we plan new basic studies of the control of the autoreactive T cell repertoire in autoimmune disease by analysis of EAE in the mouse and studies of human regulatory cells in TIDM. ..
  23. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Leonard Chess; Fiscal Year: 2004
    ..In addition, we plan new basic studies of the control of the autoreactive T cell repertoire in autoimmune disease by analysis of EAE in the mouse and studies of human regulatory cells in TIDM. ..
  24. INTEGRIN ALPHA1BETA1 AND SCLERODERMA
    Humphrey Gardner; Fiscal Year: 2000
    ..These studies will enable them to determine the role of integrin a1b1 in scleroderma and may direct them in the future to dissect the a1 signaling pathway as a target for anti-fibrotic agents. ..
  25. Monocyte Traffic and Neuropathogenesis of AIDS
    Kenneth C Williams; Fiscal Year: 2010
    ....
  26. INTEGRIN ALPHA1BETA1 AND SCLERODERMA
    Humphrey Gardner; Fiscal Year: 1999
    ..These studies will enable them to determine the role of integrin a1b1 in scleroderma and may direct them in the future to dissect the a1 signaling pathway as a target for anti-fibrotic agents. ..
  27. Monocyte Traffic and Neuropathogenesis of AIDS
    Kenneth Williams; Fiscal Year: 2009
    ....
  28. Monocyte Traffic and Neuropathogenesis of AIDS
    Kenneth Williams; Fiscal Year: 2007
    ....
  29. Pivotal role of VLA-1 in CD8 T cell retention & survival
    David Topham; Fiscal Year: 2005
    ..We will also test the prediction that the VLA-1+ memory T cells are functionally distinct and important for secondary immune protection. ..
  30. Pivotal role of VLA-1 in CD8 T cell retention & survival
    David Topham; Fiscal Year: 2004
    ..We will also test the prediction that the VLA-1+ memory T cells are functionally distinct and important for secondary immune protection. ..
  31. Pivotal role of VLA-1 in CD8 T cell retention & survival
    David Topham; Fiscal Year: 2003
    ..We will also test the prediction that the VLA-1+ memory T cells are functionally distinct and important for secondary immune protection. ..
  32. Pivotal role of VLA-1 in CD8 T cell retention & survival
    David Topham; Fiscal Year: 2006
    ..We will also test the prediction that the VLA-1+ memory T cells are functionally distinct and important for secondary immune protection. [unreadable] [unreadable]..
  33. T-CELLS AND DISEASES
    Michael Brenner; Fiscal Year: 1993
    ..These T cell clones and receptors provide a novel tool to examine the antigens and functions that may be of importance in this autoimmune disease...
  34. The Immune Paradox of Human Pregnancy: Fetal Trophoblasts and Maternal Leukocytes
    Susan Fisher; Fiscal Year: 2008
    ..Beyond human reproduction, this study could impact the fields of NK cell biology and tolerance in general, providing novel strategies for preventing the rejection of transplanted cells and tissues. ..
  35. ANTAGONISM OF VEGF-DRIVEN ANGIOGENESIS
    DONALD SENGER; Fiscal Year: 2007
    ....
  36. BETA 1 INTEGRIN ANTAGONISM & RETINAL NEOVASCULARIZATION
    DONALD SENGER; Fiscal Year: 2001
    ..Moreover, it is anticipated that findings here will suggest new strategies for therapeutic intervention. ..
  37. ADAPTATION OF NEURONS TO INHIBITORY EXTRACELLULAR MATRIX
    Maureen Condic; Fiscal Year: 2001
    ..In summary, these experiments will greatly strengthen our understanding of two novel forms of integrin regulation, and potentially provide a basis for improving the regenerative performance of adult neurons. ..
  38. Role of COX2 in Medullary Interstitial Cell Survival and Function
    Gilbert Moeckel; Fiscal Year: 2007
    ..It is necessary to understand how these cells function in order to design better drugs to treat high blood pressure. [unreadable] [unreadable]..
  39. Role of Organic Osmolytes in Renal Papillary Necrosis
    Gilbert Moeckel; Fiscal Year: 2007
    ..It is necessary to understand these processes in order to design effective diagnostic procedures, therapeutic approaches and preventive measures for RPN. ..
  40. VASCULARIZATION IN TISSUE ENGINEERED CONSTRUCTS
    Charles Patrick; Fiscal Year: 2000
    ..does TEC-recipient inosculation play in TEC vascularization? (b) What are the biological functions of CD144, principally with regards to its role in inosculation and its regulation by the unique TEC microenvironment? ..
  41. Role of COX2 in Medullary Interstitial Cell Survival and Function
    Gilbert Moeckel; Fiscal Year: 2008
    ..It is necessary to understand how these cells function in order to design better drugs to treat high blood pressure. [unreadable] [unreadable]..
  42. Rectifying defects in tumor vasculature to improve chemo- and radiation therapies
    DONALD SENGER; Fiscal Year: 2008
    ..Our proposed strategy is to achieve drug-mediated correction of these blood vessel defects in order to increase effectiveness of chemo- and radiation therapies and thereby improve cancer patient survival. ..
  43. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Leonard Chess; Fiscal Year: 2004
    ..In addition, we plan new basic studies of the control of the autoreactive T cell repertoire in autoimmune disease by analysis of EAE in the mouse and studies of human regulatory cells in TIDM. ..
  44. ADAPTATION OF NEURONS TO INHIBITORY EXTRACELLULAR MATRIX
    Maureen Condic; Fiscal Year: 2000
    ..In summary, these experiments will greatly strengthen our understanding of two novel forms of integrin regulation, and potentially provide a basis for improving the regenerative performance of adult neurons. ..
  45. BETA 1 INTEGRIN ANTAGONISM & RETINAL NEOVASCULARIZATION
    DONALD SENGER; Fiscal Year: 2000
    ..Moreover, it is anticipated that findings here will suggest new strategies for therapeutic intervention. ..
  46. Rectifying defects in tumor vasculature to improve chemo- and radiation therapies
    Donald R Senger; Fiscal Year: 2010
    ..Our proposed strategy is to achieve drug-mediated correction of these blood vessel defects in order to increase effectiveness of chemo- and radiation therapies and thereby improve cancer patient survival. ..
  47. ANTAGONISM OF VEGF DRIVEN ANGIOGENESIS
    DONALD SENGER; Fiscal Year: 1999
    ....
  48. ANTAGONISM OF VEGF DRIVEN ANGIOGENESIS
    DONALD SENGER; Fiscal Year: 2001
    ....
  49. ANTAGONISM OF VEGA-DRIVEN ANGIOGENESIS
    DONALD SENGER; Fiscal Year: 2006
    ....
  50. Specification and development of sensory neurons
    Maureen Condic; Fiscal Year: 2005
    ....
  51. VASCULARIZATION IN TISSUE ENGINEERED CONSTRUCTS
    Charles Patrick; Fiscal Year: 2001
    ..does TEC-recipient inosculation play in TEC vascularization? (b) What are the biological functions of CD144, principally with regards to its role in inosculation and its regulation by the unique TEC microenvironment? ..
  52. A NOVEL VASCULOGENESIS PROGRAM IN CYTOTROPHOBLASTS
    Susan Fisher; Fiscal Year: 2003
    ..Whether these mechanisms could inhibit tumor-induced angiogenesis, and consequently tumor growth, is another intriguing possibility. ..
  53. ANTAGONISM OF VEGA-DRIVEN ANGIOGENESIS
    DONALD SENGER; Fiscal Year: 2005
    ....
  54. A NOVEL VASCULOGENESIS PROGRAM IN CYTOTROPHOBLASTS
    Susan Fisher; Fiscal Year: 2001
    ..Whether these mechanisms could inhibit tumor-induced angiogenesis, and consequently tumor growth, is another intriguing possibility. ..
  55. Specification and development of sensory neurons
    Maureen Condic; Fiscal Year: 2006
    ....
  56. Cataloguing the Human Salivary Proteome
    Susan Fisher; Fiscal Year: 2007
    ..We envision that the data from this project will have important relevance to on-going efforts to improve oral health. ..
  57. Neuronal Guidance Mechanisms in Placental Development
    Susan Fisher; Fiscal Year: 2007
    ..In doing so, we will gain important insights into the etiology of PE, GTDs and, perhaps, other types of tumors. ..
  58. ANTAGONISM OF VEGA-DRIVEN ANGIOGENESIS
    DONALD SENGER; Fiscal Year: 2004
    ....
  59. Trophoblast Selectins and Their Uterine Mucin Ligands
    Susan Fisher; Fiscal Year: 2006
    ..abstract_text> ..
  60. Neuronal Guidance Mechanisms in Placental Development
    Susan Fisher; Fiscal Year: 2005
    ..In doing so, we will gain important insights into the etiology of PE, GTDs and, perhaps, other types of tumors. ..
  61. ANTAGONISM OF VEGF-DRIVEN ANGIOGENESIS
    DONALD SENGER; Fiscal Year: 2003
    ....
  62. ADAPTATION OF NEURONS TO INHIBITORY EXTRACELLULAR MATRIX
    Maureen Condic; Fiscal Year: 2002
    ..In summary, these experiments will greatly strengthen our understanding of two novel forms of integrin regulation, and potentially provide a basis for improving the regenerative performance of adult neurons. ..
  63. MOLECULAR MECHANISMS--BACTERIAL ADHERENCE TO CEMENTUM
    Susan Fisher; Fiscal Year: 2007
    ..This greatly simplifies the design of artificial salivary molecules that mimic the natural bacterial receptor activity of this fluid, as well as competitive inhibitors of plaque formation. ..
  64. Neuronal Guidance Mechanisms in Placental Development
    Susan Fisher; Fiscal Year: 2006
    ..In doing so, we will gain important insights into the etiology of PE, GTDs and, perhaps, other types of tumors. ..
  65. Specification and development of sensory neurons
    Maureen Condic; Fiscal Year: 2007
    ....
  66. Neuronal Guidance Mechanisms in Placental Development
    Susan Fisher; Fiscal Year: 2009
    ..In doing so, we will gain important insights into the etiology of PE, GTDs and, perhaps, other types of tumors. ..
  67. ANTAGONISM OF VEGF DRIVEN ANGIOGENESIS
    DONALD SENGER; Fiscal Year: 2000
    ....
  68. Neuronal Guidance Mechanisms in Placental Development
    Susan Fisher; Fiscal Year: 2006
    ..In doing so, we will gain important insights into the etiology of PE, GTDs and, perhaps, other types of tumors. ..
  69. 3D Adipose Tissue Generation and Functional Verification
    Charles Patrick; Fiscal Year: 2004
    ..abstract_text> ..
  70. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Leonard Chess; Fiscal Year: 2007
    ..In addition, we plan new basic studies of the control of the autoreactive T cell repertoire in autoimmune disease by analysis of EAE in the mouse and studies of human regulatory cells in TIDM. ..
  71. Specification and development of sensory neurons
    Maureen Condic; Fiscal Year: 2009
    ....